The Formins FMNL1 and mDia1 Regulate Coiling Phagocytosis of Borrelia burgdorferi by Primary Human Macrophages

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Fig. S1 to S3 and Movie S1 to S3 legends.

  PDF, 63K

• Supplemental file 2 -

  Fig. S1. mDia1 is specifically enriched at tips of filopodia induced by contact with Borrelia. Fig. S2. Primary human macrophages express the filopodia marker fascin. Fig. S3. Number of attached Borrelia per macrophage under formin knockdown.

  PDF, 2.2M

• Supplemental file 3 -

  Movie S1. Live cell imaging reveals coiling phagocytosis of B. burgdorferi by a primary human macrophage.

  MOV, 12M

• Supplemental file 4 -

  Movie S2. The filopodia marker fascin and FMNL1 localize to Borrelia-induced protrusions.

  MOV, 779K

• Supplemental file 5 -

  Movie S3. The filopodia marker fascin and mDia1 localize to Borrelia-induced protrusions.

  MOV, 9.8M