Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Fig. S1 (4EGI disrupts eIF4E-4GI association

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• Supplemental file 2 -

  Fig. S2 (Localization of mTOR in SG)

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• Supplemental file 3 -

  Fig. S3 (PP242 and Torin1 inhibit SG formation)

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• Supplemental file 4 -

  Fig. S4 (SG inhibitor pp242 has modest effect on translation initiation)

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• Supplemental file 5 -

  Fig. S5 (Depletion of 4E-BP1 rescues bortezomib-SG formation)

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• Supplemental file 6 -

  Fig. S6 (Depletion of eIF4GI impairs formation of SG)

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• Supplemental file 7 -

  Fig. S7 (PP242 sensitizes MCF-7 cells to bortezomib-mediated apoptosis)

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• Supplemental file 8 -

  Supplemental figure legends

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