Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

Supplemental Data

Files in this Data Supplement:

• Supplemental Figures (.pdf, 403 KB) - Supplemental Figure S1. Caspase-1 protects hepatocytes from undergoing apoptosis after hypoxia/reoxygenation. Supplemental Figure S2. Caspase-1 deficiency led to impaired induction of autophagy after hypoxia/reoxygenation, but not after starvation. Supplemental Figure S3. Representative caspase-8 expression in WT and caspase-1 -/- hepatocytes cultured under normoxia or treated with hypoxia for 6 or 18h. Supplemental Figure S4. Plasma IL18 in WT and caspase-1-/- mice. Supplemental Figure S5. Western blot and quantification of LC3II in livers of caspase-1 -/- mice given control adenovirus or mouse beclin1 adenovirus.