The PIM-2 Kinase Is an Essential Component of the Ultraviolet Damage Response That Acts Upstream to E2F-1 and ATM

Files in this Data Supplement:

• Supplementary Figure 1 (.jpg, 1.1 MB) - Silencing and induced expression and activity of PIM-2 under various treatment conditions.
• Supplementary Figure 2 (.jpg, 1.1 MB) - Reduced UVC-induce apoptosis and increased survival in cells over-expressing the 34kDa isoform of PIM-2.
• Supplementary Figure 3 (.jpg, 611 KB) - Mild resistance to etoposide-induced apoptosis in PIM-2 over-expressing cells.
• Supplementary Figure 4 (.jpg, 819 KB) - PIM-2 up-regulation upon exposure to UV radiation does not depend on E2F1 or activated ATM.
• Supplementary Figure 5 (.jpg, 875 KB) - Reduced γH2AX accumulation following UVC in cells over-expressing the 41kDa isoform of PIM-2.
• Legends to supplementary figures (.docx, 17 KB) - Legends to supplementary figures.