Table 2. Effect of chronic stress and lithium treatment on behavior determined by using ANOVA (a = 0.05)

Behavior

Stress

Lithium

Stress and lithium

Total grid crosses

(open field)

F(1,39) = 14.0;

P < 0.01*

F(1,39) = 1.54;

P = 0.22

F(1,39) = 0.25;

P = 0.62

Rearing

(open field)

F(1,39) = 6.72;

P < 0.05*

F(1,39) = 1.40;

P = 0.24

F(1,39) = 0.02;

P = 0.88

Latency to inner grids (open field)

F(1,39) = 4.19

P = 0.05

F(1,39) = 5.29;

P < 0.05*

F(1,39) = 0.01;

P = 0.99

Inner/total ratio

(open field)

F(1,39) = 4.78;

P < 0.05*

F(1,39) = 4.89;

P < 0.05*

F(1,39) = 0.53;

P = 0.47

Total entries

(plus-maze)

F(1,35) = 14.1;

P < 0.01*

F(1,35) = 0.83;

P = 0.37

F(1,35) = 0.73;

P = 0.40

Latency to explore (plus-maze)

F(1,35) = 6.58;

P < 0.05*

F(1,35) = 0.05;

P = 0.82

F(1,35) = 0.21;

P = 0.64

Open arm entries

(plus-maze)

F(1,35) = 3.99;

P < 0.05*

F(1,35) = 2.75;

P = 0.11

F(1,35) = 2.75;

P = 0.11

% time open/closed (plus-maze)

F(1,35) = 3.89;

P = 0.05

F(1,35) = 2.83;

P = 0.10

F(1,35) = 2.82;

P = 0.10

% open/closed entries (plus-maze)

F(1,35) = 4.11;

P = 0.05

F(1,35) = 3.05;

P = 0.09

F(1,35) = 3.05;

P = 0.09

Chronic stress significantly altered all measures of behavior in the open field and plus maze, and none of these effects were prevented by lithium.

*Significant effects.

†Marginal effects.