Table 2. Effect of chronic stress and lithium treatment on behavior determined by using ANOVA (a = 0.05)
Behavior |
Stress |
Lithium |
Stress and lithium |
Total grid crosses (open field) |
F(1,39) = 14.0; P < 0.01* |
F(1,39) = 1.54; P = 0.22 |
F(1,39) = 0.25; P = 0.62 |
Rearing (open field) |
F(1,39) = 6.72; P < 0.05* |
F(1,39) = 1.40; P = 0.24 |
F(1,39) = 0.02; P = 0.88 |
Latency to inner grids (open field) |
F(1,39) = 4.19 P = 0.05† |
F(1,39) = 5.29; P < 0.05* |
F(1,39) = 0.01; P = 0.99 |
Inner/total ratio (open field) |
F(1,39) = 4.78; P < 0.05* |
F(1,39) = 4.89; P < 0.05* |
F(1,39) = 0.53; P = 0.47 |
Total entries (plus-maze) |
F(1,35) = 14.1; P < 0.01* |
F(1,35) = 0.83; P = 0.37 |
F(1,35) = 0.73; P = 0.40 |
Latency to explore (plus-maze) |
F(1,35) = 6.58; P < 0.05* |
F(1,35) = 0.05; P = 0.82 |
F(1,35) = 0.21; P = 0.64 |
Open arm entries (plus-maze) |
F(1,35) = 3.99; P < 0.05* |
F(1,35) = 2.75; P = 0.11 |
F(1,35) = 2.75; P = 0.11 |
% time open/closed (plus-maze) |
F(1,35) = 3.89; P = 0.05† |
F(1,35) = 2.83; P = 0.10 |
F(1,35) = 2.82; P = 0.10 |
% open/closed entries (plus-maze) |
F(1,35) = 4.11; P = 0.05† |
F(1,35) = 3.05; P = 0.09 |
F(1,35) = 3.05; P = 0.09 |
Chronic stress significantly altered all measures of behavior in the open field and plus maze, and none of these effects were prevented by lithium.
*Significant effects.
†
Marginal effects.