A New System for Comparative Functional Genomics of Saccharomyces Yeasts

Files in this data supplement:

  • File S1: Supporting methods, Figures S1-S7, Tables S1-S7, and Supporting references (PDF, 3.4 MB)
  • Figure S1: GAL1 expression in S. bayanus is increased during carbon switches (PDF, 500 KB)
  • Figure S2: Pheromone response in 670.55 knockout mutant (ortholog of IME1) is similar to wild type (PDF, 499 KB)
  • Figure S3: The 643.11 knockout mutant (ortholog of RPM2) is respiratory deficient (PDF, 1.7 MB)
  • Figure S4: Haploid-specific cell clumping is disrupted in a mutant of 678.66 (ortholog of AMN1) (PDF, 289 KB)
  • Figure S5: The 668.17 knockout mutant (ortholog of ARD1) shows changes in gene expression of mating-type specific genes, as well as global changes in expression (PDF, 532 KB)
  • Figure S6: The S. bayanus GAL80 ortholog 555.11 represses the expression of galactose structural genes when glucose is present (PDF, 88 KB)
  • Figure S7: The AUC (area under the precision/recall curve) for various biological functions predicted from S. bayanus gene expression data, shown for A. all GO terms and B. GO SLIM terms (PDF, 359 KB)
  • Table S1: Description of S. bayanus strains used in this study (PDF, 98 KB)
  • Table S2: List of experimental treatments in this S. bayanus gene expression compendium (PDF, 69 KB)
  • Table S3: Filtered and transformed expression data from Figure 1 (.zip, 8.3 MB)
  • Table S4: Gene function predictions for S. bayanus (.zip, 19.6 KB)
  • Table S5: Changes in predicted gene function between S. bayanus and S. cerevisiae, filtered for those in the top probability score in either species (PDF, 809 KB)
  • Table S6: Position weight matrices of the motifs enriched in the oxidative stress cluster (PDF, 70 KB)