"Classification Performance Measures on hotspot and all descriptors. 
 Experimental data for log10(koff) is based on the kinetically characterized mutations from SKEMPI which satisfy  |?log10(koff)| >1
 Descriptors are ranked according to highest MCC. 
TPR – True Positive Rate, FPR – False Positive Rate, MCC – Matthew’s Correlation Coefficient, F1 – F1-Score, Acc. – Accuracy, Spec. - Specificity, Prec. – Precision, Rec. – Recall",,,,,,,,,,,,,,,,,,,,,
|?log10(koff)|  >1 (CDS2) Hotspot Descriptors,,,,,,,,,,,,|?log10(koff)|  >1 (CDS2) Hotspot & Molecular Descriptors,,,,,,,,,
Rank,Hotspot Descriptors,Descriptor Category,TPR,FPR,MCC,F1,Acc,Spec,Prec,,Rank,Descriptor,Descriptor Category,TPR,FPR,MCC,F1,Acc,Spec,Prec,Descriptor Type
1,HSEner_PosCoop,RFSpot,0.58,0.03,0.62,0.65,0.92,0.97,0.75,,1,HSEner_PosCoop,RFSpot,0.58,0.03,0.62,0.65,0.92,0.97,0.75,Hotspot
2,CoreHSEnergy,RFSpot_KFC2,0.39,0.00,0.57,0.55,0.92,1.00,0.92,,2,CoreHSEnergy,RFSpot_KFC2,0.39,0.00,0.57,0.55,0.92,1.00,0.92,Hotspot
3,HSEner_PosCoop,RFSpot_KFC2,0.42,0.02,0.52,0.54,0.91,0.98,0.76,,3,HSEner_PosCoop,RFSpot_KFC2,0.42,0.02,0.52,0.54,0.91,0.98,0.76,Hotspot
4,Int_HS_Energy,RFSpot_KFC2,0.39,0.01,0.52,0.52,0.91,0.99,0.80,,4,Int_HS_Energy,RFSpot_KFC2,0.39,0.01,0.52,0.52,0.91,0.99,0.80,Hotspot
5,HS_PosCoop,RFSpot_KFC2,0.61,0.08,0.51,0.58,0.89,0.92,0.54,,5,HS_PosCoop,RFSpot_KFC2,0.61,0.08,0.51,0.58,0.89,0.92,0.54,Hotspot
6,CoreHSEnergy,RFSpot,0.39,0.02,0.50,0.51,0.91,0.98,0.75,,6,CoreHSEnergy,RFSpot,0.39,0.02,0.50,0.51,0.91,0.98,0.75,Hotspot
7,HS_PosCoop,RFSpot,0.65,0.10,0.48,0.55,0.86,0.90,0.48,,7,HS_PosCoop,RFSpot,0.65,0.10,0.48,0.55,0.86,0.90,0.48,Hotspot
8,Int_HS_Energy,RFSpot,0.35,0.02,0.47,0.48,0.90,0.98,0.73,,8,PY_fa_atr,PB,0.45,0.04,0.47,0.52,0.89,0.96,0.61,Molecular
9,RimHSEnergy,KFC2a,0.52,0.08,0.44,0.51,0.87,0.92,0.50,,9,Int_HS_Energy,RFSpot,0.35,0.02,0.47,0.48,0.90,0.98,0.73,Hotspot
10,Int_Energy_1,KFC2a,0.52,0.10,0.39,0.47,0.85,0.90,0.43,,10,CP_TB,CP,0.71,0.15,0.45,0.52,0.83,0.85,0.41,Molecular
11,HSEner_NegCoop,RFSpot,0.32,0.03,0.38,0.42,0.89,0.97,0.59,,11,RimHSEnergy,KFC2a,0.52,0.08,0.44,0.51,0.87,0.92,0.50,Hotspot
12,SuppHSEnergy,KFC2a,0.55,0.12,0.37,0.46,0.84,0.88,0.40,,12,ACE19_INTERaction,PB,0.48,0.07,0.43,0.50,0.88,0.93,0.52,Molecular
13,HSEner_NegCoop,Hotpoint1,0.45,0.08,0.37,0.45,0.86,0.92,0.45,,13,ACE19_HYDRophobic,PB,0.42,0.05,0.42,0.48,0.89,0.95,0.57,Molecular
14,Int_Energy_1,KFC2b,0.58,0.15,0.36,0.44,0.82,0.85,0.36,,14,ACE19_SCREENing,PB,0.45,0.07,0.40,0.47,0.87,0.93,0.50,Molecular
15,No_HS,RFSpot,0.26,0.02,0.35,0.36,0.89,0.98,0.62,,15,AP_MPS,AP,0.48,0.08,0.40,0.48,0.86,0.92,0.47,Molecular
16,Int_HS_Energy,KFC2a,0.45,0.10,0.34,0.42,0.84,0.90,0.40,,16,Int_Energy_1,KFC2a,0.52,0.10,0.39,0.47,0.85,0.90,0.43,Hotspot
17,RimHS,KFC2a,0.32,0.05,0.33,0.39,0.87,0.95,0.50,,17,HSEner_NegCoop,RFSpot,0.32,0.03,0.38,0.42,0.89,0.97,0.59,Hotspot
18,CoreHSEnergy,Hotpoint1,0.32,0.05,0.32,0.38,0.87,0.95,0.48,,18,SuppHSEnergy,KFC2a,0.55,0.12,0.37,0.46,0.84,0.88,0.40,Hotspot
19,Int_HS_Energy,Hotpoint1,0.26,0.03,0.31,0.35,0.88,0.97,0.53,,19,HSEner_NegCoop,Hotpoint1,0.45,0.08,0.37,0.45,0.86,0.92,0.45,Hotspot
20,RimHS,RFSpot,0.32,0.06,0.31,0.38,0.86,0.94,0.45,,20,FX1_int_Energy_VdW,PB,0.45,0.08,0.37,0.45,0.86,0.92,0.45,Molecular
21,HS_NegCoop,RFSpot,0.35,0.08,0.30,0.38,0.85,0.92,0.41,,21,FX2_Energy_VdW,PB,0.45,0.08,0.37,0.45,0.86,0.92,0.45,Molecular
22,HSEner_NegCoop,RFSpot_KFC2,0.35,0.08,0.30,0.38,0.85,0.92,0.41,,22,Int_Energy_1,KFC2b,0.58,0.15,0.36,0.44,0.82,0.85,0.36,Hotspot
23,MaxClusterSize,RFSpot,0.10,0.00,0.29,0.18,0.89,1.00,1.00,,23,No_HS,RFSpot,0.26,0.02,0.35,0.36,0.89,0.98,0.62,Hotspot
24,RimHSEnergy,RFSpot,0.32,0.07,0.29,0.36,0.86,0.93,0.42,,24,AP_DOPE,AP,0.81,0.31,0.35,0.41,0.71,0.69,0.28,Molecular
25,No_Clusters,RFSpot,0.45,0.13,0.28,0.38,0.82,0.87,0.33,,25,Int_HS_Energy,KFC2a,0.45,0.10,0.34,0.42,0.84,0.90,0.40,Hotspot
26,No_HS,KFC2a,0.42,0.12,0.28,0.38,0.82,0.88,0.34,,26,RimHS,KFC2a,0.32,0.05,0.33,0.39,0.87,0.95,0.50,Hotspot
27,SuppHSEnergy,RFSpot_KFC2,0.23,0.03,0.28,0.31,0.87,0.97,0.50,,27,CoreHSEnergy,Hotpoint1,0.32,0.05,0.32,0.38,0.87,0.95,0.48,Hotspot
28,SuppHS,KFC2a,0.32,0.08,0.27,0.35,0.85,0.92,0.38,,28,Int_HS_Energy,Hotpoint1,0.26,0.03,0.31,0.35,0.88,0.97,0.53,Hotspot
29,HSEner_NegCoop,KFC2a,0.45,0.15,0.26,0.37,0.80,0.85,0.31,,29,RimHS,RFSpot,0.32,0.06,0.31,0.38,0.86,0.94,0.45,Hotspot
30,SuppHSEnergy,KFC2b,0.39,0.12,0.25,0.35,0.82,0.88,0.32,,30,HS_NegCoop,RFSpot,0.35,0.08,0.30,0.38,0.85,0.92,0.41,Hotspot
31,No_HS,Hotpoint2,0.48,0.18,0.25,0.36,0.78,0.82,0.28,,31,HSEner_NegCoop,RFSpot_KFC2,0.35,0.08,0.30,0.38,0.85,0.92,0.41,Hotspot
32,HS_NegCoop,RFSpot_KFC2,0.29,0.08,0.24,0.32,0.84,0.92,0.36,,32,CP_RMFCA,CP,0.58,0.20,0.30,0.40,0.77,0.80,0.30,Molecular
33,No_HS,Hotpoint1,0.32,0.09,0.23,0.33,0.83,0.91,0.33,,33,MaxClusterSize,RFSpot,0.10,0.00,0.29,0.18,0.89,1.00,1.00,Hotspot
34,Int_HS_Energy,KFC2b,0.39,0.13,0.23,0.34,0.81,0.87,0.30,,34,RimHSEnergy,RFSpot,0.32,0.07,0.29,0.36,0.86,0.93,0.42,Hotspot
35,CoreHS,RFSpot,0.29,0.09,0.21,0.31,0.83,0.91,0.32,,35,No_Clusters,RFSpot,0.45,0.13,0.28,0.38,0.82,0.87,0.33,Hotspot
36,CoreHS,Hotpoint2,0.13,0.02,0.21,0.21,0.87,0.98,0.50,,36,CP_SKOb,CP,0.55,0.19,0.28,0.38,0.77,0.81,0.29,Molecular
37,CoreHS,KFC2b,0.13,0.02,0.19,0.20,0.87,0.98,0.44,,37,No_HS,KFC2a,0.42,0.12,0.28,0.38,0.82,0.88,0.34,Hotspot
38,RimHSEnergy,RFSpot_KFC2,0.16,0.04,0.18,0.23,0.86,0.96,0.38,,38,FX1_int_Energy_SolvH,PB,0.52,0.17,0.28,0.38,0.79,0.83,0.30,Molecular
39,No_HS,KFC2b,0.29,0.11,0.18,0.29,0.82,0.89,0.28,,39,SuppHSEnergy,RFSpot_KFC2,0.23,0.03,0.28,0.31,0.87,0.97,0.50,Hotspot
40,CoreHSEnergy,KFC2a,0.35,0.15,0.18,0.30,0.79,0.85,0.26,,40,GEOMETRIC,CP,0.74,0.34,0.27,0.36,0.67,0.66,0.24,Molecular
41,RimHS,Hotpoint2,0.29,0.11,0.17,0.28,0.81,0.89,0.27,,41,NSc,CP,0.77,0.37,0.27,0.36,0.65,0.63,0.23,Molecular
42,No_Clusters,Hotpoint2,0.48,0.26,0.17,0.30,0.71,0.74,0.21,,42,FX2_Energy_SolvH,PB,0.52,0.18,0.27,0.38,0.78,0.82,0.30,Molecular
43,Int_Energy_1,RFSpot_KFC2,0.55,0.31,0.16,0.30,0.67,0.69,0.20,,43,SuppHS,KFC2a,0.32,0.08,0.27,0.35,0.85,0.92,0.38,Hotspot
44,CoreHS,Hotpoint1,0.29,0.12,0.16,0.27,0.80,0.88,0.26,,44,HSEner_NegCoop,KFC2a,0.45,0.15,0.26,0.37,0.80,0.85,0.31,Hotspot
45,Int_Energy_1,RFSpot,0.45,0.25,0.15,0.29,0.71,0.75,0.21,,45,CP_HLPL,CP,0.52,0.19,0.25,0.36,0.77,0.81,0.28,Molecular
46,AVG_HS_PathLength,KFC2a,0.71,0.49,0.15,0.28,0.54,0.51,0.17,,46,SuppHSEnergy,KFC2b,0.39,0.12,0.25,0.35,0.82,0.88,0.32,Hotspot
47,HSEner_NegCoop,Hotpoint2,0.55,0.36,0.13,0.27,0.63,0.64,0.18,,47,No_HS,Hotpoint2,0.48,0.18,0.25,0.36,0.78,0.82,0.28,Hotspot
48,HS_NegCoop,KFC2b,0.39,0.23,0.12,0.26,0.72,0.77,0.20,,48,CP_SKOa,CP,0.58,0.25,0.24,0.35,0.73,0.75,0.25,Molecular
49,SuppHS,RFSpot_KFC2,0.16,0.07,0.12,0.20,0.84,0.93,0.26,,49,HS_NegCoop,RFSpot_KFC2,0.29,0.08,0.24,0.32,0.84,0.92,0.36,Hotspot
50,CoreHSEnergy,KFC2b,0.29,0.16,0.11,0.24,0.77,0.84,0.21,,50,No_HS,Hotpoint1,0.32,0.09,0.23,0.33,0.83,0.91,0.33,Hotspot
51,SuppHSEnergy,Hotpoint2,0.52,0.36,0.11,0.26,0.63,0.64,0.17,,51,Int_HS_Energy,KFC2b,0.39,0.13,0.23,0.34,0.81,0.87,0.30,Hotspot
52,HSEner_NegCoop,KFC2b,0.29,0.16,0.11,0.24,0.77,0.84,0.20,,52,DCOMPLEX,AP,0.81,0.47,0.22,0.32,0.56,0.53,0.20,Molecular
53,HS_NegCoop,Hotpoint1,0.23,0.12,0.11,0.22,0.80,0.88,0.22,,53,CP_Qm,CP,0.61,0.30,0.22,0.33,0.69,0.70,0.23,Molecular
54,RimHS,Hotpoint1,0.03,0.00,0.10,0.06,0.87,1.00,0.50,,54,PY_fa_dun,PB,0.81,0.49,0.21,0.31,0.55,0.51,0.19,Molecular
55,MaxClusterSize,Hotpoint2,0.03,0.00,0.10,0.06,0.87,1.00,0.50,,55,PY_fa_pair,PB,0.48,0.21,0.21,0.33,0.75,0.79,0.25,Molecular
56,HS_PosCoop,KFC2a,0.45,0.31,0.10,0.25,0.66,0.69,0.18,,56,CoreHS,RFSpot,0.29,0.09,0.21,0.31,0.83,0.91,0.32,Hotspot
57,SuppHS,Hotpoint2,0.29,0.18,0.09,0.23,0.75,0.82,0.19,,57,CoreHS,Hotpoint2,0.13,0.02,0.21,0.21,0.87,0.98,0.50,Hotspot
58,HS_NegCoop,KFC2a,0.45,0.33,0.09,0.24,0.64,0.67,0.17,,58,AP_T2,AP,0.74,0.44,0.20,0.31,0.58,0.56,0.20,Molecular
59,RimHS,RFSpot_KFC2,0.06,0.02,0.08,0.11,0.86,0.98,0.29,,59,DFIRE,AP,0.77,0.47,0.20,0.31,0.56,0.53,0.19,Molecular
60,HSEner_PosCoop,KFC2b,0.35,0.25,0.08,0.23,0.70,0.75,0.17,,60,CP_Qp,CP,0.45,0.20,0.20,0.32,0.75,0.80,0.25,Molecular
61,AVG_HS_PathLength,RFSpot_KFC2,0.29,0.21,0.07,0.21,0.73,0.79,0.17,,61,FX1_int_BackHbond,PB,0.77,0.49,0.19,0.30,0.55,0.51,0.19,Molecular
62,SuppHS,KFC2b,0.23,0.16,0.06,0.19,0.76,0.84,0.17,,62,FX2_BackHbond,PB,0.77,0.49,0.19,0.30,0.55,0.51,0.19,Molecular
63,HSEner_PosCoop,KFC2a,0.39,0.31,0.06,0.22,0.65,0.69,0.15,,63,CoreHS,KFC2b,0.13,0.02,0.19,0.20,0.87,0.98,0.44,Hotspot
64,No_HS,RFSpot_KFC2,0.16,0.12,0.04,0.16,0.79,0.88,0.16,,64,RimHSEnergy,RFSpot_KFC2,0.16,0.04,0.18,0.23,0.86,0.96,0.38,Hotspot
65,HSEner_PosCoop,Hotpoint2,0.35,0.31,0.04,0.21,0.65,0.69,0.14,,65,CP_BL,CP,0.48,0.24,0.18,0.31,0.73,0.76,0.23,Molecular
66,No_Clusters,KFC2a,0.19,0.16,0.03,0.17,0.76,0.84,0.15,,66,No_HS,KFC2b,0.29,0.11,0.18,0.29,0.82,0.89,0.28,Hotspot
67,HS_PosCoop,KFC2b,0.45,0.42,0.02,0.21,0.56,0.58,0.13,,67,CP_MJPL,CP,0.48,0.24,0.18,0.31,0.72,0.76,0.22,Molecular
68,RimHSEnergy,Hotpoint1,0.03,0.02,0.02,0.05,0.86,0.98,0.17,,68,CoreHSEnergy,KFC2a,0.35,0.15,0.18,0.30,0.79,0.85,0.26,Hotspot
69,SuppHS,RFSpot,0.03,0.02,0.02,0.05,0.86,0.98,0.17,,69,CHARM_elec,PB,0.58,0.32,0.18,0.31,0.66,0.68,0.21,Molecular
70,SuppHS,Hotpoint1,0.10,0.08,0.01,0.12,0.81,0.92,0.14,,70,RimHS,Hotpoint2,0.29,0.11,0.17,0.28,0.81,0.89,0.27,Hotspot
71,CoreHS,RFSpot_KFC2,0.19,0.18,0.01,0.16,0.74,0.82,0.14,,71,CP_MSBM,CP,0.74,0.48,0.17,0.29,0.55,0.52,0.18,Molecular
72,No_Clusters,RFSpot_KFC2,0.16,0.15,0.01,0.15,0.76,0.85,0.14,,72,DDFIRE,AP,0.71,0.46,0.17,0.29,0.56,0.54,0.18,Molecular
73,CoreHSEnergy,Hotpoint2,0.45,0.44,0.01,0.20,0.55,0.56,0.13,,73,No_Clusters,Hotpoint2,0.48,0.26,0.17,0.30,0.71,0.74,0.21,Hotspot
74,MaxClusterSize,KFC2a,0.00,0.00,0.00,0.00,0.87,1.00,NaN,,74,Int_Energy_1,RFSpot_KFC2,0.55,0.31,0.16,0.30,0.67,0.69,0.20,Hotspot
75,MaxClusterSize,KFC2b,0.00,0.00,0.00,0.00,0.87,1.00,NaN,,75,CoreHS,Hotpoint1,0.29,0.12,0.16,0.27,0.80,0.88,0.26,Hotspot
76,RimHSEnergy,KFC2b,0.00,0.00,0.00,0.00,0.87,1.00,NaN,,76,CP_SJKG,CP,0.65,0.41,0.16,0.29,0.60,0.59,0.19,Molecular
77,RimHS,KFC2b,0.00,0.00,0.00,0.00,0.87,1.00,NaN,,77,OPUS_PSP2,CP,0.48,0.27,0.15,0.29,0.70,0.73,0.21,Molecular
78,MaxClusterSize,RFSpot_KFC2,0.00,0.00,0.00,0.00,0.87,1.00,NaN,,78,Int_Energy_1,RFSpot,0.45,0.25,0.15,0.29,0.71,0.75,0.21,Hotspot
79,CoreHS,KFC2a,0.16,0.16,0.00,0.14,0.75,0.84,0.13,,79,AVG_HS_PathLength,KFC2a,0.71,0.49,0.15,0.28,0.54,0.51,0.17,Hotspot
80,AVG_HS_PathLength,Hotpoint2,0.55,0.55,0.00,0.20,0.46,0.45,0.13,,80,FX1_int_kn electrostatic,PB,0.61,0.40,0.14,0.28,0.60,0.60,0.18,Molecular
81,SuppHSEnergy,RFSpot,0.03,0.04,-0.01,0.05,0.84,0.96,0.11,,81,FX2_kn electrostatic,PB,0.61,0.40,0.14,0.28,0.60,0.60,0.18,Molecular
82,HSEner_PosCoop,Hotpoint1,0.26,0.27,-0.01,0.16,0.67,0.73,0.12,,82,CP_TS,CP,0.45,0.26,0.14,0.28,0.70,0.74,0.20,Molecular
83,No_Clusters,KFC2b,0.19,0.21,-0.01,0.15,0.71,0.79,0.12,,83,CP_SKOIP,CP,0.68,0.47,0.14,0.27,0.55,0.53,0.17,Molecular
84,Int_Energy_1,Hotpoint1,0.29,0.31,-0.02,0.17,0.64,0.69,0.12,,84,CP_GKS,CP,0.42,0.24,0.13,0.27,0.71,0.76,0.20,Molecular
85,Int_Energy_1,Hotpoint2,0.29,0.31,-0.02,0.17,0.64,0.69,0.12,,85,HSEner_NegCoop,Hotpoint2,0.55,0.36,0.13,0.27,0.63,0.64,0.18,Hotspot
86,Int_HS_Energy,Hotpoint2,0.29,0.31,-0.02,0.17,0.64,0.69,0.12,,86,OPUS_PSP1,CP,0.74,0.55,0.13,0.27,0.49,0.45,0.16,Molecular
87,HS_PosCoop,Hotpoint2,0.16,0.19,-0.02,0.13,0.73,0.81,0.11,,87,AP_T1,AP,0.71,0.52,0.13,0.27,0.51,0.48,0.17,Molecular
88,HS_NegCoop,Hotpoint2,0.29,0.32,-0.02,0.17,0.63,0.68,0.12,,88,FX1_int_ helix dipole,PB,0.81,0.63,0.12,0.26,0.43,0.37,0.16,Molecular
89,MaxClusterSize,Hotpoint1,0.00,0.00,-0.02,0.00,0.87,1.00,0.00,,89,HS_NegCoop,KFC2b,0.39,0.23,0.12,0.26,0.72,0.77,0.20,Hotspot
90,RimHSEnergy,Hotpoint2,0.35,0.40,-0.03,0.17,0.57,0.60,0.11,,90,SuppHS,RFSpot_KFC2,0.16,0.07,0.12,0.20,0.84,0.93,0.26,Hotspot
91,SuppHSEnergy,Hotpoint1,0.10,0.13,-0.03,0.10,0.77,0.87,0.10,,91,CoreHSEnergy,KFC2b,0.29,0.16,0.11,0.24,0.77,0.84,0.21,Hotspot
92,HS_PosCoop,Hotpoint1,0.35,0.42,-0.05,0.17,0.55,0.58,0.11,,92,SuppHSEnergy,Hotpoint2,0.52,0.36,0.11,0.26,0.63,0.64,0.17,Hotspot
93,AVG_HS_PathLength,Hotpoint1,0.23,0.30,-0.05,0.14,0.64,0.70,0.10,,93,HSEner_NegCoop,KFC2b,0.29,0.16,0.11,0.24,0.77,0.84,0.20,Hotspot
94,No_Clusters,Hotpoint1,0.13,0.31,-0.14,0.08,0.61,0.69,0.06,,94,FX1_int_Electro,PB,0.39,0.24,0.11,0.25,0.71,0.76,0.19,Molecular
95,AVG_HS_PathLength,RFSpot,0.03,0.19,-0.14,0.03,0.71,0.81,0.02,,95,HS_NegCoop,Hotpoint1,0.23,0.12,0.11,0.22,0.80,0.88,0.22,Hotspot
96,AVG_HS_PathLength,KFC2b,0.19,0.40,-0.14,0.10,0.55,0.60,0.07,,96,RimHS,Hotpoint1,0.03,0.00,0.10,0.06,0.87,1.00,0.50,Hotspot
,,,,,,,,,,,97,MaxClusterSize,Hotpoint2,0.03,0.00,0.10,0.06,0.87,1.00,0.50,Hotspot
,,,,,,,,,,,98,HS_PosCoop,KFC2a,0.45,0.31,0.10,0.25,0.66,0.69,0.18,Hotspot
,,,,,,,,,,,99,CP_BFKV,CP,0.52,0.37,0.10,0.25,0.61,0.63,0.17,Molecular
,,,,,,,,,,,100,PY_fa_intra_rep,PB,0.81,0.67,0.10,0.25,0.39,0.33,0.15,Molecular
,,,,,,,,,,,101,SuppHS,Hotpoint2,0.29,0.18,0.09,0.23,0.75,0.82,0.19,Hotspot
,,,,,,,,,,,102,CP_TSC,CP,0.29,0.18,0.09,0.23,0.75,0.82,0.19,Molecular
,,,,,,,,,,,103,AP_DARS,AP,0.61,0.48,0.09,0.25,0.53,0.52,0.16,Molecular
,,,,,,,,,,,104,FX2_Electro,PB,0.35,0.24,0.09,0.24,0.71,0.76,0.18,Molecular
,,,,,,,,,,,105,CP_RMFCEN2,CP,0.48,0.36,0.09,0.25,0.62,0.64,0.16,Molecular
,,,,,,,,,,,106,HS_NegCoop,KFC2a,0.45,0.33,0.09,0.24,0.64,0.67,0.17,Hotspot
,,,,,,,,,,,107,CHARM_sasa,PB,0.52,0.39,0.09,0.25,0.60,0.61,0.16,Molecular
,,,,,,,,,,,108,RimHS,RFSpot_KFC2,0.06,0.02,0.08,0.11,0.86,0.98,0.29,Hotspot
,,,,,,,,,,,109,CP_MJ2,CP,0.42,0.31,0.08,0.24,0.66,0.69,0.17,Molecular
,,,,,,,,,,,110,CP_MJ3h,CP,0.58,0.46,0.08,0.24,0.55,0.54,0.16,Molecular
,,,,,,,,,,,111,HSEner_PosCoop,KFC2b,0.35,0.25,0.08,0.23,0.70,0.75,0.17,Hotspot
,,,,,,,,,,,112,NIP,CP,0.65,0.53,0.08,0.25,0.50,0.47,0.15,Molecular
,,,,,,,,,,,113,FX1_int_SideHbond,PB,0.71,0.60,0.08,0.24,0.44,0.40,0.15,Molecular
,,,,,,,,,,,114,PY_hbond_lr_bb,PB,0.97,0.90,0.08,0.24,0.21,0.10,0.14,Molecular
,,,,,,,,,,,115,PY_hbond_bb_sc,PB,0.65,0.54,0.07,0.24,0.49,0.46,0.15,Molecular
,,,,,,,,,,,116,CP_TD,CP,0.55,0.45,0.07,0.24,0.55,0.55,0.15,Molecular
,,,,,,,,,,,117,FX1_int_Energy_Ionisation,PB,0.94,0.87,0.07,0.24,0.23,0.13,0.14,Molecular
,,,,,,,,,,,118,AVG_HS_PathLength,RFSpot_KFC2,0.29,0.21,0.07,0.21,0.73,0.79,0.17,Hotspot
,,,,,,,,,,,119,CHARM_vdwaals,PB,0.90,0.83,0.07,0.24,0.26,0.17,0.14,Molecular
,,,,,,,,,,,120,CP_VD,CP,0.39,0.30,0.06,0.22,0.66,0.70,0.16,Molecular
,,,,,,,,,,,121,CP_MS,CP,0.35,0.27,0.06,0.22,0.68,0.73,0.16,Molecular
,,,,,,,,,,,122,SuppHS,KFC2b,0.23,0.16,0.06,0.19,0.76,0.84,0.17,Hotspot
,,,,,,,,,,,123,HSEner_PosCoop,KFC2a,0.39,0.31,0.06,0.22,0.65,0.69,0.15,Hotspot
,,,,,,,,,,,124,CP_BT,CP,0.45,0.38,0.05,0.22,0.60,0.62,0.15,Molecular
,,,,,,,,,,,125,CP_Qa,CP,0.61,0.55,0.04,0.23,0.47,0.45,0.14,Molecular
,,,,,,,,,,,126,CP_TEl,CP,0.52,0.46,0.04,0.22,0.54,0.54,0.14,Molecular
,,,,,,,,,,,127,FX2_SideHbond,PB,0.65,0.59,0.04,0.23,0.44,0.41,0.14,Molecular
,,,,,,,,,,,128,No_HS,RFSpot_KFC2,0.16,0.12,0.04,0.16,0.79,0.88,0.16,Hotspot
,,,,,,,,,,,129,FX2_ helix dipole,PB,0.65,0.59,0.04,0.23,0.44,0.41,0.14,Molecular
,,,,,,,,,,,130,HSEner_PosCoop,Hotpoint2,0.35,0.31,0.04,0.21,0.65,0.69,0.14,Hotspot
,,,,,,,,,,,131,CP_RMFCEN1,CP,0.48,0.43,0.03,0.22,0.56,0.57,0.14,Molecular
,,,,,,,,,,,132,CP_MJ2h,CP,0.39,0.34,0.03,0.21,0.62,0.66,0.14,Molecular
,,,,,,,,,,,133,No_Clusters,KFC2a,0.19,0.16,0.03,0.17,0.76,0.84,0.15,Hotspot
,,,,,,,,,,,134,AP_URS,AP,0.52,0.48,0.02,0.21,0.52,0.52,0.14,Molecular
,,,,,,,,,,,135,ACE19_COULomb,PB,0.48,0.45,0.02,0.21,0.54,0.55,0.14,Molecular
,,,,,,,,,,,136,FX2_Energy_Ionisation,PB,0.90,0.88,0.02,0.23,0.22,0.12,0.13,Molecular
,,,,,,,,,,,137,HS_PosCoop,KFC2b,0.45,0.42,0.02,0.21,0.56,0.58,0.13,Hotspot
,,,,,,,,,,,138,RimHSEnergy,Hotpoint1,0.03,0.02,0.02,0.05,0.86,0.98,0.17,Hotspot
,,,,,,,,,,,139,SuppHS,RFSpot,0.03,0.02,0.02,0.05,0.86,0.98,0.17,Hotspot
,,,,,,,,,,,140,SuppHS,Hotpoint1,0.10,0.08,0.01,0.12,0.81,0.92,0.14,Hotspot
,,,,,,,,,,,141,CoreHS,RFSpot_KFC2,0.19,0.18,0.01,0.16,0.74,0.82,0.14,Hotspot
,,,,,,,,,,,142,No_Clusters,RFSpot_KFC2,0.16,0.15,0.01,0.15,0.76,0.85,0.14,Hotspot
,,,,,,,,,,,143,CoreHSEnergy,Hotpoint2,0.45,0.44,0.01,0.20,0.55,0.56,0.13,Hotspot
,,,,,,,,,,,144,PY_hbond_sc,PB,0.45,0.45,0.00,0.20,0.54,0.55,0.13,Molecular
,,,,,,,,,,,145,MaxClusterSize,KFC2a,0.00,0.00,0.00,0.00,0.87,1.00,NaN,Hotspot
,,,,,,,,,,,146,MaxClusterSize,KFC2b,0.00,0.00,0.00,0.00,0.87,1.00,NaN,Hotspot
,,,,,,,,,,,147,RimHSEnergy,KFC2b,0.00,0.00,0.00,0.00,0.87,1.00,NaN,Hotspot
,,,,,,,,,,,148,RimHS,KFC2b,0.00,0.00,0.00,0.00,0.87,1.00,NaN,Hotspot
,,,,,,,,,,,149,MaxClusterSize,RFSpot_KFC2,0.00,0.00,0.00,0.00,0.87,1.00,NaN,Hotspot
,,,,,,,,,,,150,FX1_int_water bonds,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,151,FX1_int_loop_entropy,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,152,FX1_int_cis_bond,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,153,FX1_int_disulfide,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,154,FX1_int_partial covalent interactions,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,155,FX1_int_Entropy Complex,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,156,FX2_water bonds,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,157,FX2_loop_entropy,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,158,FX2_cis_bond,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,159,FX2_disulfide,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,160,FX2_partial covalent interactions,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,161,FX2_Entropy Complex,PB,1.00,1.00,0.00,0.23,0.13,0.00,0.13,Molecular
,,,,,,,,,,,162,CoreHS,KFC2a,0.16,0.16,0.00,0.14,0.75,0.84,0.13,Hotspot
,,,,,,,,,,,163,FX1_int_energy_torsion,PB,0.71,0.71,0.00,0.21,0.34,0.29,0.13,Molecular
,,,,,,,,,,,164,AVG_HS_PathLength,Hotpoint2,0.55,0.55,0.00,0.20,0.46,0.45,0.13,Hotspot
,,,,,,,,,,,165,PY_pro_close,PB,0.94,0.94,0.00,0.22,0.17,0.06,0.13,Molecular
,,,,,,,,,,,166,FX2_Entropy_mainc,PB,0.61,0.62,-0.01,0.21,0.41,0.38,0.13,Molecular
,,,,,,,,,,,167,SuppHSEnergy,RFSpot,0.03,0.04,-0.01,0.05,0.84,0.96,0.11,Hotspot
,,,,,,,,,,,168,HSEner_PosCoop,Hotpoint1,0.26,0.27,-0.01,0.16,0.67,0.73,0.12,Hotspot
,,,,,,,,,,,169,No_Clusters,KFC2b,0.19,0.21,-0.01,0.15,0.71,0.79,0.12,Hotspot
,,,,,,,,,,,170,ACE19_SOLVation,PB,0.52,0.54,-0.02,0.20,0.47,0.46,0.12,Molecular
,,,,,,,,,,,171,FX2_energy_torsion,PB,0.68,0.70,-0.02,0.21,0.35,0.30,0.12,Molecular
,,,,,,,,,,,172,CP_MJ1,CP,0.68,0.70,-0.02,0.21,0.35,0.30,0.12,Molecular
,,,,,,,,,,,173,Int_Energy_1,Hotpoint1,0.29,0.31,-0.02,0.17,0.64,0.69,0.12,Hotspot
,,,,,,,,,,,174,Int_Energy_1,Hotpoint2,0.29,0.31,-0.02,0.17,0.64,0.69,0.12,Hotspot
,,,,,,,,,,,175,Int_HS_Energy,Hotpoint2,0.29,0.31,-0.02,0.17,0.64,0.69,0.12,Hotspot
,,,,,,,,,,,176,HS_PosCoop,Hotpoint2,0.16,0.19,-0.02,0.13,0.73,0.81,0.11,Hotspot
,,,,,,,,,,,177,HS_NegCoop,Hotpoint2,0.29,0.32,-0.02,0.17,0.63,0.68,0.12,Hotspot
,,,,,,,,,,,178,MaxClusterSize,Hotpoint1,0.00,0.00,-0.02,0.00,0.87,1.00,0.00,Hotspot
,,,,,,,,,,,179,RimHSEnergy,Hotpoint2,0.35,0.40,-0.03,0.17,0.57,0.60,0.11,Hotspot
,,,,,,,,,,,180,SuppHSEnergy,Hotpoint1,0.10,0.13,-0.03,0.10,0.77,0.87,0.10,Hotspot
,,,,,,,,,,,181,FX1_int_Entropy_mainc,PB,0.58,0.64,-0.04,0.19,0.39,0.36,0.12,Molecular
,,,,,,,,,,,182,HS_PosCoop,Hotpoint1,0.35,0.42,-0.05,0.17,0.55,0.58,0.11,Hotspot
,,,,,,,,,,,183,AVG_HS_PathLength,Hotpoint1,0.23,0.30,-0.05,0.14,0.64,0.70,0.10,Hotspot
,,,,,,,,,,,184,CP_TEs,CP,0.35,0.50,-0.10,0.15,0.48,0.50,0.09,Molecular
,,,,,,,,,,,185,CHARM_total,PB,0.87,0.94,-0.10,0.21,0.16,0.06,0.12,Molecular
,,,,,,,,,,,186,AP_DOPE_HR,AP,0.61,0.76,-0.11,0.18,0.29,0.24,0.10,Molecular
,,,,,,,,,,,187,No_Clusters,Hotpoint1,0.13,0.31,-0.14,0.08,0.61,0.69,0.06,Hotspot
,,,,,,,,,,,188,AVG_HS_PathLength,RFSpot,0.03,0.19,-0.14,0.03,0.71,0.81,0.02,Hotspot
,,,,,,,,,,,189,OPUS_PSP3,CP,0.87,0.96,-0.14,0.21,0.14,0.04,0.12,Molecular
,,,,,,,,,,,190,FX2_Energy_vdwclash,PB,0.87,0.96,-0.14,0.21,0.14,0.04,0.12,Molecular
,,,,,,,,,,,191,AVG_HS_PathLength,KFC2b,0.19,0.40,-0.14,0.10,0.55,0.60,0.07,Hotspot
,,,,,,,,,,,192,FX1_int_Energy_vdwclash,PB,0.90,0.98,-0.16,0.21,0.13,0.02,0.12,Molecular
,,,,,,,,,,,193,PY_hbond_sr_bb,PB,0.81,0.94,-0.16,0.20,0.16,0.06,0.11,Molecular
,,,,,,,,,,,194,PY_fa_rep,PB,0.84,0.96,-0.17,0.20,0.14,0.04,0.11,Molecular
,,,,,,,,,,,195,FX1_int_backbone_vdwclash,PB,0.52,0.76,-0.18,0.15,0.28,0.24,0.09,Molecular
,,,,,,,,,,,196,FX2_backbone_vdwclash,PB,0.48,0.75,-0.19,0.15,0.28,0.25,0.09,Molecular
,,,,,,,,,,,197,CP_RO,CP,0.52,0.78,-0.21,0.15,0.25,0.22,0.09,Molecular
,,,,,,,,,,,198,FX2_Entropy_sidec,PB,0.45,0.74,-0.21,0.14,0.29,0.26,0.08,Molecular
,,,,,,,,,,,199,FX1_int_Entropy_sidec,PB,0.42,0.73,-0.23,0.13,0.29,0.27,0.08,Molecular
,,,,,,,,,,,200,CHARM_gb+sasa,PB,0.39,0.72,-0.24,0.12,0.29,0.28,0.07,Molecular
,,,,,,,,,,,201,CHARM_gb,PB,0.39,0.73,-0.25,0.12,0.28,0.27,0.07,Molecular
,,,,,,,,,,,202,ACE19_SASL,PB,0.42,0.79,-0.29,0.12,0.23,0.21,0.07,Molecular
,,,,,,,,,,,203,PY_fa_sol,PB,0.61,0.91,-0.30,0.16,0.16,0.09,0.09,Molecular
,,,,,,,,,,,204,FX2_Energy_SolvP,PB,0.61,0.93,-0.34,0.15,0.14,0.07,0.09,Molecular
,,,,,,,,,,,205,FX1_int_Energy_SolvP,PB,0.61,0.94,-0.37,0.15,0.13,0.06,0.09,Molecular
,,,,,,,,,,,206,ACE19_SELF,PB,0.52,0.93,-0.42,0.13,0.13,0.07,0.07,Molecular