Files in this Data Supplement:
- Supplementary Figure 1 - Supplementary Figure 1. Effect of hepatic GCGR knockdown on lipoprotein lipase (LPL) from si-Control and si-GCGR treated mice. Plasma LPL activity was determined using RB-LPL2 plasma assay kit (Roar Biomedical) according to manufacturer's instruction. Data are shown as mean ± SEM, n=8.
- Supplementary Figure 2 - Supplementary Figure 2. Hepatic knockdown of fructose-1, 6 bisphosphatase 1 (FBP1) reduced fasting (A) and ambient (B) plasma glucose levels and increased LDL-C levels (C) in si-Control and si-FBP1 treated db/db mice. Data are shown as mean ± SEM, n=8.
- Supplementary Figure 3 - Supplementary Figure 3. si-GCGGR in CETP-tg/Ldlr(+/-) mice lowered plasma glucose and increased LDL cholesterol levels. Nonfasting plasma glucose (A) and LDL cholesterol levels before and 4 days after treatment with phosphate buffered saline (PBS), si-Control,or si-GCGR in CETP-tg/Ldlr(+/-) mice. Data are shown as mean ± SEM, n=8.