Predicting Functionally Informative Mutations in Escherichia coli BamA Using Evolutionary Covariance Analysis

Files in this data supplement:

  • Supporting Information: File S1, Tables S1-S2, and Figures S1-S4 (PDF, 1 MB)
  • File S1: Supporting Methods (PDF, 388 KB)
  • Table S1: Strains and plasmids (PDF, 758 KB)
  • Table S2: Primers (PDF, 308 KB)
  • Figure S1: Effect of sequence informational entropy SI, Sj on pair DIij score (PDF, 493 KB)
  • Figure S2: Alignment of BamA POTRA 5 and FhaC POTRA 2 domains (PDF, 162 KB)
  • Figure S3: Correlation of DCADIij and DCADIZij scores where alpha=0 and 0.6 respectively (PDF, 365 KB)
  • Figure S4: Effect of shrinkage with model matrix on DCA true positive rates (PDF, 424 KB)