InteractionList |
Interaction #5 |
Name: | CyclinA-Cdk2 |
wwpdb | 1FIN [identical object] |
intact | EBI-1030422 [identical object] |
Experiments: | cheng-2006-1 |
Participants: | |
Participant #13 | Cdk2 | Biological Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Participant #14 | Ccna2 | Biological Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | direct interaction | psi-mi | MI:0407 |
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Interaction attributes: | |
cooperative mechanism | pre-assembly |
affected interaction | CyclinA_pCdk2-Cdc6 |
cooperative effect outcome | positive cooperative effect |
pre-assembly response | configurational pre-organization |
Interaction #6 |
Name: | CyclinA-Cdk2 |
wwpdb | 1FIN [identical object] |
intact | EBI-1030422 [identical object] |
Experiments: | stevenson-2002-1 jeffrey-1995-1 |
Participants: | |
Participant #15 | Cdk2 | Biological Role: | Name: | allosteric molecule | psi-mi | MI:1159 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Participant #16 | Ccna2 | Biological Role: | Name: | allosteric effector | psi-mi | MI:1160 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | direct interaction | psi-mi | MI:0407 |
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Interaction attributes: | |
cooperative mechanism | allostery |
affected interaction | CyclinA_pCdk2-Cdc6 |
cooperative effect outcome | positive cooperative effect |
allosteric molecule | Participant#15 |
allosteric effector | Participant#16 |
allosteric mechanism | allosteric change in structure |
allosteric response | allosteric v-type response |
allostery type | heterotropic allostery |
Interaction #7 |
Name: | CyclinA-Cdk2 |
wwpdb | 1FIN [identical object] |
intact | EBI-1030422 [identical object] |
Experiments: | stevenson-2002-1 jeffrey-1995-1 |
Participants: | |
Participant #17 | Cdk2 | Biological Role: | Name: | allosteric molecule | psi-mi | MI:1159 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Participant #18 | Ccna2 | Biological Role: | Name: | allosteric effector | psi-mi | MI:1160 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | direct interaction | psi-mi | MI:0407 |
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Interaction attributes: | |
cooperative mechanism | allostery |
affected interaction | CyclinA_pCdk2-Cdc6 |
cooperative effect outcome | positive cooperative effect |
allosteric molecule | Participant#17 |
allosteric effector | Participant#18 |
allosteric mechanism | allosteric change in structure |
allosteric response | allosteric k-type response |
allostery type | heterotropic allostery |
Interaction #8 |
Name: | CyclinA-Cdk2 |
wwpdb | 1FIN [identical object] |
intact | EBI-1030422 [identical object] |
Experiments: | jeffrey-1995-1 |
Participants: | |
Participant #19 | Cdk2 | Biological Role: | Name: | allosteric molecule | psi-mi | MI:1159 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Participant #20 | Ccna2 | Biological Role: | Name: | allosteric effector | psi-mi | MI:1160 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | direct interaction | psi-mi | MI:0407 |
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Interaction attributes: | |
cooperative mechanism | allostery |
affected interaction | CyclinA_Cdk2-Cdk7 |
affected interaction | CyclinA_Cdk2-Cdk7 |
affected interaction | CyclinA_Cdk2-Cdk7 |
cooperative effect outcome | positive cooperative effect |
allosteric molecule | Participant#19 |
allosteric effector | Participant#20 |
allosteric mechanism | allosteric change in structure |
allosteric response | allosteric k-type response |
allostery type | heterotropic allostery |
Interaction #9 |
Name: | CyclinA_Cdk2-Cdk7 |
wwpdb | 1JST [identical object] |
dip | DIP57013E [identical object] |
Experiments: | stevenson-2002-1 Brown-1999-1 |
Participants: | |
Participant #21 | CyclinA-Cdk2 | Biological Role: | Name: | enzyme target | psi-mi | MI:0502 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Feature #50 | phosphorylated residue () [ 160 .. 160 ] | resulting-ptm | | participant-ref | Participant#13 | |
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Participant #22 | Cdk7 | Biological Role: | Name: | enzyme | psi-mi | MI:0501 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | phosphorylation reaction | psi-mi | MI:0217 |
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Interaction attributes: | |
cooperative mechanism | allostery |
affected interaction | CyclinA_pCdk2-Cdc6 |
cooperative effect outcome | positive cooperative effect |
allosteric molecule | Participant#13 |
allosteric post-translational modification | Feature#50 |
allosteric mechanism | allosteric change in structure |
allosteric response | allosteric k-type response |
allostery type | heterotropic allostery |
Interaction #10 |
Name: | CyclinA_Cdk2-Cdk7 |
wwpdb | 1JST [identical object] |
dip | DIP57013E [identical object] |
Experiments: | stevenson-2002-1 russo-1996-1 |
Participants: | |
Participant #23 | CyclinA-Cdk2 | Biological Role: | Name: | enzyme target | psi-mi | MI:0502 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Feature #51 | phosphorylated residue () [ 160 .. 160 ] | resulting-ptm | | participant-ref | Participant#13 | |
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Participant #24 | Cdk7 | Biological Role: | Name: | enzyme | psi-mi | MI:0501 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | phosphorylation reaction | psi-mi | MI:0217 |
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Interaction attributes: | |
cooperative mechanism | allostery |
affected interaction | CyclinA_pCdk2-Cdc6 |
cooperative effect outcome | positive cooperative effect |
allosteric molecule | Participant#13 |
allosteric post-translational modification | Feature#51 |
allosteric mechanism | allosteric change in structure |
allosteric response | allosteric v-type response |
allostery type | heterotropic allostery |
Interaction #11 |
Name: | CyclinA_Cdk2-Cdk7 |
wwpdb | 1JST [identical object] |
dip | DIP57013E [identical object] |
Experiments: | cheng-2006-1 Brown-1999-1 |
Participants: | |
Participant #25 | CyclinA-Cdk2 | Biological Role: | Name: | enzyme target | psi-mi | MI:0502 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Feature #52 | phosphorylated residue () [ 160 .. 160 ] | resulting-ptm | | participant-ref | Participant#13 | |
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Participant #26 | Cdk7 | Biological Role: | Name: | enzyme | psi-mi | MI:0501 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
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Interaction Type: | Name: | phosphorylation reaction | psi-mi | MI:0217 [identical object] |
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Interaction attributes: | |
cooperative mechanism | pre-assembly |
affected interaction | CyclinA_pCdk2-Cdc6 |
cooperative effect outcome | positive cooperative effect |
pre-assembly response | altered physicochemical compatibility |
Interaction #12 |
Name: | CyclinA_pCdk2-Cdc6 |
wwpdb | 2CCI [identical object] |
Experiments: | cheng-2006-1 |
Participants: | |
Participant #27 | CyclinA-Cdk2 | Biological Role: | Name: | enzyme | psi-mi | MI:0501 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Feature #53 | phosphorylated residue () [ 160 .. 160 ] | prerequisite-ptm | | participant-ref | Participant#13 | |
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Participant #28 | Cdc6 | Biological Role: | Name: | enzyme target | psi-mi | MI:0502 [identical object] |
| Experimental Role: | Name: | unspecified role | psi-mi | MI:0499 [identical object] |
| Feature #54 | phosphorylated residue () [ 74 .. 74 ] | resulting-ptm | | |
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Interaction Type: | Name: | phosphorylation reaction | psi-mi | MI:0217 [identical object] |
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