Fig. 13.

Effects of DPFE on sleep/wake architecture of rats. The impact of oral administration of vehicle 20% HPBCD + Tween 20 (black) or DPFE: 10 mg/kg (green); 30 mg/kg (blue); or 100 mg/kg (red) with n = 8 for each treatment condition during the light phase on time spent in six different sleep-wake states (A) through (F). Line graphs indicate state amounts expressed as percentage of time spent in state (Y-axis) for consecutive 30-minute periods over 20-hour postadministration (x-axis); inset bar graphs indicate mean ± S.E.M. time (min) spent in state during the first 4 hours after administration. *Significantly different from vehicle (P < 0.05), Wilcoxon-Mann–Whitney rank sum test.