TABLE 3.
Summary of in vitro and in vivo pharmacokinetic parameters
| VU0364289 | DPFE | |
|---|---|---|
| Cmax (ng/ml) | 1280 | 1093 |
| Tmax (hr) | 0.25 | 0.25 |
| Plasma protein binding | 94% (h); 90% (r) | 97% (h); 96% (r) |
| Rat Fu (free fraction) | 0.10 | 0.04 |
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