Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer

Files in this data supplement:

  • Supporting Information: Figures S1-S2 and Tables S1-S2 (PDF, 506 KB)
  • Figure S1: Evolutionary conservation of amino acids that are mutated in human LATS1 and LATS2. (PDF, 354 KB)
  • Figure S2: Western blot analysis of human LATS1 and LATS2 proteins in HEK293T cells (PDF, 339 KB)
  • Table S1: Detail information on non-synonymous mutations for human LATS1 (58 samples) and LATS2 (43 samples) genes collected in the COSMIC database (http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/) is presented. (.xlsx, 139 KB)
  • Table S2: in silico analysis of hLATS1 and hLATS2 mutations from the COSMIC database (.xlsx, 35 KB)