Files in this Data Supplement:
Supplemental Table 1. List of MD simulations.
Supplemental Table 2. List of REMD simulations.
Supplemental Table 3. Analysis of distances between the SP and the Ptm23 sub-pocket in D3R/R-22 vs D3R/C3.
Supplemental Table 4. Analysis of the Prokink associated with Pro2.59.
Supplemental Table 5. Radioligand membrane binding affinities of NAPS and R-22 at selected chimera and mutant constructs.
Supplemental Table 6. Radioligand whole cell binding affinities of NAPS and R-22 at wildtype constructs.
Supplemental Figure 1. Receptor-ligand interactions of R-22 in D3R and D2R, and C3 in D3R.
Supplemental Figure 2. The binding mode of SP within the SBP can be categorized...
Supplemental Figure 3. A scatterplot of the D3R/R-22 receptor-ligand distances...
Supplemental Figure 4. The number of water molecules in the SBP...
Supplemental Figure 5. Divergent EL1-EL2 interfaces in D3R (A) and D2R (B).