Fig. 6. Chronic effects of peptide-YY_3-36 (PYY_3-36) on feeding in Pomc^-/- and wild-type mice. (A) Chronic feeding response of 12- to 15-week-old, freely feeding, male wild-type to twice daily i.p. injections of PYY_3-36 (solid line) or saline (dashed line) for 7 days. Data represent mean cumulative food intake ± SEM during the treatment period (n = 8 for each genotype). (B) Chronic feeding response of 12- to 15-week-old, freely feeding, male Pomc^-/- mice to twice daily i.p. injections of PYY_3-36 (solid line) or saline (dashed line) for 7 days. Data represent mean cumulative food intake ± SEM during the treatment period (n = 8 for each genotype).