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Supplemental Materials and Methods. Fig. S1. Functionalized catanionic vesicles displaying F. tularensis LVS LPS as the only F. tularensis component are protective against F. tularensis LVS challenge but fail to induce robust IgG antibody responses. Fig. S2. Surface charge, but not size, of vesicles is affected by the F. tularensis protein content of the nanoparticles. Fig. S3. Catanionic vesicles associate with bacterial LPS in addition to the proteins, and addition of protease inhibitors does not significantly affect the components incorporated into the vesicles. Fig. S4. Mice immunized with Schu S4-V show a delay in clinical symptoms after i.n. challenge with F. tularensis Schu S4, and the route of immunization affects IgG titer.
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