Insights into the Complexity and Functionality of Hepatitis C Virus NS5A Phosphorylation

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Fig. S1 to S4 (Identification of S146, S222, SS222/5, and T348 phosphorylation sites.)

  Fig. S5 (Effect of long-term passage on hyperphosphorylation of NS5A.)

  Fig. S6 (Phosphorylation of T348 does not affect the binding of SH3 domains to the P2 polyproline motif.)

  Fig. S7 (Structural prediction of a phosphomimetic at position 146 shows no significant alteration to NS5A domain I monomer structure.)

  Table S1 (Phenotype 57 of mutants in putative LCS I phosphorylation sites in the context of genotype 1b or 2a.)

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