Evolution and Diversity in Human Herpes Simplex Virus Genomes

Supplemental material

Files in this Data Supplement:

• Supplemental file 5 -

  Fig. S1 (G+C-richness peaks in terminal and inverted repeats, in a pattern common across HSV-1 strains.)

  Fig. S2 (Read coverage scan from four HSV-1 strains depicting likely deletions in the UL55-UL56 region.)

  Fig. S3 (Bootscan analysis of similarity between subgroups of HSV-1 strains suggests frequent recombination.)

  PDF, 1.7M

• Supplemental file 1 -

  Table S1 (Details of the sequences of 20 new determined and 6 previously sequenced HSV-1 strains.)

  XLS, 56K

• Supplemental file 2 -

  Table S2 (Variations in the HSV-1 genome that are associated with inversions at potential hairpin (stem-loop) structures.)

  XLS, 36K

• Supplemental file 3 -

  Table S3 (Excel file containing AA conservation for every HSV-1 protein, calculated by percent identity or by weighted median divergence.)

  XLS, 68K

• Supplemental file 4 -

  Table S4 (Omega values and likelihood of positive selection for HSV-1 proteins.)

  XLS, 72K