Published March 31, 2014 // JCB vol. 204 no. 7 1209-1218
The Rockefeller University Press, doi: 10.1083/jcb.201312098

ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo

• Video 1  UNC-60A (ADF/cofilin) regulates F-actin dynamics during invadopodia formation.

• Video 2  UNC-60A (ADF/cofilin) regulates F-actin dynamics during invadopodia formation.

• Video 3  Spot-tracking analysis of AC invadopodia lifetimes.

• Video 4  FLIP analysis reveals dynamic recycling of invadopodial membrane through the endolysosomal compartment.

• Video 5  The invadopodial membrane component PI(4,5)P2 localizes to static intracellular membrane vesicles in the absence of unc-60a (ADF/cofilin).

• Supplemental material (PDF)