Annotation Cluster 1 Enrichment Score: 4.119706368113084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE topological domain:Extracellular 49 27.37430167597765 2.091364231072807E-6 NRP2, ACVRL1, OR10A2, F2RL1, FASLG, GJA1, DLK1, LY9, VIPR1, GJA3, TLR9, IL1RAP, CLEC4D, BOC, RAMP3, GPR174, ZP1, SIT1, FMR1NB, NTSR2, TAS2R13, LAT2, SIRPG, HEPACAM, CD34, LRP11, FGFR2, IL22RA1, C21ORF63, PRRG2, CRB2, TTYH2, GPR26, ENTPD3, SCNN1B, LYSMD4, KLB, TMEM92, ATP11B, KIR2DS2, ATP11A, GJB2, OR12D2, GPR34, PRLR, STAB1, CLEC7A, SLC46A3, MUC17 173 2719 19113 1.9909925231777241 0.0013793496574705522 6.899128185838821E-4 0.0031290137985307 SP_PIR_KEYWORDS membrane 85 47.486033519553075 6.040142599188688E-6 NRP2, ACVRL1, HFE2, MYO7B, OR10A2, C9ORF79, F2RL1, GJA1, FASLG, SYT6, LRRC4C, LY9, DLK1, VIPR1, TLR9, GJA3, MCTP2, TMEM20, HPSE, SDPR, CH25H, IL1RAP, CLEC4D, C7ORF45, BOC, RAMP3, GPR174, SIT1, ZP1, FMR1NB, MFI2, C1ORF212, NAV3, CYP2E1, NTSR2, LAT2, SIRPG, TAS2R13, BSPRY, LRAT, HEPACAM, CD34, LRP11, RYR2, FGFR2, C11ORF64, GCNT3, IL22RA1, C21ORF63, PTPLAD2, PEX5L, CRB2, PRRG2, GPR26, TTYH2, B3GNT7, HS6ST2, ENTPD3, RASA3, SCNN1B, PCSK6, FGFBP1, LYSMD4, TMEM92, KLB, MUC20, KIR2DS2, ATP11B, ATP11A, RHD, MAN1C1, CD1E, GJB2, FRRS1, CYBA, OR12D2, GPR34, PRLR, TMEM163, STAB1, SLC17A2, RHBDL2, CLEC7A, SLC46A3, MUC17 173 6256 19235 1.5106653681829605 0.0014546197762443924 4.851085510008124E-4 0.007801167739585058 UP_SEQ_FEATURE topological domain:Cytoplasmic 55 30.726256983240223 7.691308973114107E-6 NRP2, ACVRL1, OR10A2, F2RL1, FASLG, GJA1, SYT6, DLK1, LY9, VIPR1, GJA3, TLR9, IL1RAP, CLEC4D, BOC, RAMP3, GPR174, ZP1, SIT1, FMR1NB, NTSR2, TAS2R13, LAT2, SIRPG, HEPACAM, CD34, LRP11, RYR2, FGFR2, GCNT3, IL22RA1, C21ORF63, PRRG2, CRB2, GPR26, B3GNT7, TTYH2, HS6ST2, ENTPD3, SCNN1B, LYSMD4, KLB, TMEM92, ATP11B, KIR2DS2, ATP11A, MAN1C1, GJB2, OR12D2, GPR34, PRLR, STAB1, CLEC7A, SLC46A3, MUC17 173 3374 19113 1.8009446601176629 0.005063420890997761 0.0016906636965681177 0.011506972702712837 UP_SEQ_FEATURE transmembrane region 71 39.66480446927375 1.1221426572862528E-5 NRP2, ACVRL1, OR10A2, C9ORF79, F2RL1, GJA1, FASLG, SYT6, LRRC4C, LY9, DLK1, VIPR1, TLR9, GJA3, MCTP2, TMEM20, CH25H, IL1RAP, CLEC4D, C7ORF45, BOC, RAMP3, GPR174, SIT1, ZP1, FMR1NB, C1ORF212, NTSR2, LAT2, SIRPG, TAS2R13, LRAT, HEPACAM, CD34, LRP11, RYR2, FGFR2, C11ORF64, GCNT3, IL22RA1, C21ORF63, PTPLAD2, CRB2, PRRG2, GPR26, B3GNT7, TTYH2, HS6ST2, ENTPD3, SCNN1B, LYSMD4, TMEM92, KLB, KIR2DS2, ATP11B, ATP11A, RHD, MAN1C1, CD1E, GJB2, FRRS1, OR12D2, GPR34, PRLR, TMEM163, STAB1, SLC17A2, RHBDL2, CLEC7A, SLC46A3, MUC17 173 4911 19113 1.5972436538006576 0.007378824899715086 0.0018498327195841657 0.0167879703866447 SP_PIR_KEYWORDS transmembrane 71 39.66480446927375 1.4043167540049153E-5 NRP2, ACVRL1, OR10A2, C9ORF79, F2RL1, GJA1, FASLG, SYT6, LRRC4C, LY9, DLK1, VIPR1, TLR9, GJA3, MCTP2, TMEM20, CH25H, IL1RAP, CLEC4D, C7ORF45, BOC, RAMP3, GPR174, SIT1, ZP1, FMR1NB, C1ORF212, NTSR2, LAT2, SIRPG, TAS2R13, LRAT, HEPACAM, CD34, LRP11, RYR2, FGFR2, C11ORF64, GCNT3, IL22RA1, C21ORF63, PTPLAD2, CRB2, PRRG2, GPR26, B3GNT7, TTYH2, HS6ST2, ENTPD3, SCNN1B, LYSMD4, TMEM92, KLB, KIR2DS2, ATP11B, ATP11A, RHD, MAN1C1, CD1E, GJB2, FRRS1, OR12D2, GPR34, PRLR, TMEM163, STAB1, SLC17A2, RHBDL2, CLEC7A, SLC46A3, MUC17 173 4973 19235 1.5873985417206673 0.0033787064233148367 8.457489378986827E-4 0.018136638374988134 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 77 43.01675977653631 8.453214336203948E-5 NRP2, ACVRL1, HFE2, OR10A2, C9ORF79, F2RL1, GJA1, FASLG, SYT6, LRRC4C, LY9, DLK1, VIPR1, TLR9, GJA3, MCTP2, TMEM20, CH25H, IL1RAP, CLEC4D, C7ORF45, BOC, RAMP3, GPR174, SIT1, ZP1, FMR1NB, MFI2, C1ORF212, CYP2E1, NTSR2, LAT2, SIRPG, TAS2R13, LRAT, HEPACAM, CD34, LRP11, RYR2, FGFR2, C11ORF64, GCNT3, IL22RA1, C21ORF63, PTPLAD2, CRB2, PRRG2, GPR26, TTYH2, B3GNT7, HS6ST2, ENTPD3, RASA3, SCNN1B, LYSMD4, TMEM92, KLB, KIR2DS2, ATP11B, ATP11A, RHD, MAN1C1, CD1E, GJB2, FRRS1, CYBA, OR12D2, GPR34, PRLR, TMEM163, STAB1, SLC17A2, AMOT, RHBDL2, CLEC7A, SLC46A3, MUC17 128 5485 12782 1.401854489516864 0.017097437317923014 0.017097437317923014 0.1062438014638678 GOTERM_CC_FAT GO:0016021~integral to membrane 74 41.340782122905026 1.8199927964133734E-4 NRP2, ACVRL1, OR10A2, C9ORF79, F2RL1, GJA1, FASLG, SYT6, LRRC4C, LY9, DLK1, VIPR1, TLR9, GJA3, MCTP2, TMEM20, CH25H, IL1RAP, CLEC4D, C7ORF45, BOC, RAMP3, GPR174, SIT1, ZP1, FMR1NB, MFI2, C1ORF212, NTSR2, LAT2, SIRPG, TAS2R13, LRAT, HEPACAM, CD34, LRP11, RYR2, FGFR2, C11ORF64, GCNT3, IL22RA1, C21ORF63, PTPLAD2, CRB2, PRRG2, GPR26, TTYH2, B3GNT7, HS6ST2, ENTPD3, SCNN1B, LYSMD4, TMEM92, KLB, KIR2DS2, ATP11B, ATP11A, RHD, MAN1C1, CD1E, GJB2, FRRS1, CYBA, OR12D2, GPR34, PRLR, TMEM163, STAB1, SLC17A2, AMOT, RHBDL2, CLEC7A, SLC46A3, MUC17 128 5297 12782 1.3950526241268641 0.03645032157500494 0.01839433659692291 0.22861591366526435 GOTERM_CC_FAT GO:0005886~plasma membrane 50 27.932960893854748 0.017630651519978578 NRP2, ACVRL1, HFE2, OR10A2, MYO7B, F2RL1, FASLG, GJA1, SYT6, VIPR1, GJA3, TLR9, SDPR, IL1RAP, BOC, RAMP3, GPR174, ZP1, SIT1, MFI2, NTSR2, LAT2, SIRPG, HEPACAM, CD34, RYR2, FGFR2, ANKS4B, PRRG2, CRB2, TTYH2, GPR26, ENTPD3, RASA3, SCNN1B, FGFBP1, KLB, MUC20, KIR2DS2, RHD, CD1E, GJB2, CYBA, OR12D2, GPR34, STAB1, SLC17A2, AMOT, CLEC7A, MUC17 128 3777 12782 1.321940362721737 0.9734502842190513 0.4538105430826257 20.042585311600945 SP_PIR_KEYWORDS cell membrane 30 16.75977653631285 0.020150809651174058 FGFR2, HFE2, MYO7B, OR10A2, F2RL1, GJA1, FASLG, VIPR1, GJA3, CRB2, TTYH2, GPR26, IL1RAP, SCNN1B, RASA3, FGFBP1, BOC, GPR174, ZP1, SIT1, KLB, MUC20, MFI2, KIR2DS2, NTSR2, GJB2, OR12D2, LAT2, GPR34, MUC17 173 2194 19235 1.5203049831121134 0.9925975346630416 0.3355718380172201 23.120116799225276 Annotation Cluster 2 Enrichment Score: 3.9847023609208323 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS glycoprotein 68 37.988826815642454 7.384705918617436E-7 NRP2, ACVRL1, HFE2, WNT3A, C9ORF79, F2RL1, FASLG, DLK1, LY9, VIPR1, PSG11, TLR9, APOD, HPSE, CH25H, IL1RAP, SEMA3D, CLEC4D, BOC, MYC, RAMP3, GPR174, SIT1, ZP1, EGFL6, MFI2, CILP, SIRPG, TAS2R13, HEPACAM, CD34, LRP11, RYR2, MFAP5, FGFR2, CCL1, GCNT3, IL22RA1, LPAL2, C21ORF63, CRB2, B3GNT7, TTYH2, HS6ST2, ENTPD3, PCSK6, SCNN1B, FGFBP1, LYSMD4, KLB, FETUB, MUC20, KIR2DS2, ECM2, COL5A3, MAN1C1, PLG, CD1E, FRRS1, LAMA1, OR12D2, GPR34, PRLR, STAB1, SLC17A2, CLEC7A, SLC46A3, MUC17 173 4318 19235 1.7509444267443448 1.7795564237688133E-4 1.7795564237688133E-4 9.538044571488768E-4 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 66 36.87150837988827 9.040519934483523E-7 NRP2, ACVRL1, HFE2, WNT3A, C9ORF79, F2RL1, FASLG, DLK1, LY9, VIPR1, PSG11, TLR9, APOD, HPSE, CH25H, IL1RAP, SEMA3D, CLEC4D, BOC, RAMP3, GPR174, SIT1, ZP1, EGFL6, MFI2, CILP, SIRPG, TAS2R13, HEPACAM, CD34, LRP11, RYR2, MFAP5, FGFR2, CCL1, GCNT3, IL22RA1, LPAL2, C21ORF63, CRB2, B3GNT7, TTYH2, HS6ST2, ENTPD3, PCSK6, SCNN1B, LYSMD4, KLB, FETUB, MUC20, KIR2DS2, ECM2, COL5A3, MAN1C1, PLG, CD1E, FRRS1, LAMA1, OR12D2, GPR34, PRLR, STAB1, SLC17A2, CLEC7A, SLC46A3, MUC17 173 4129 19113 1.7659638507833357 5.964966105341807E-4 5.964966105341807E-4 0.0013526169027056056 SP_PIR_KEYWORDS disulfide bond 50 27.932960893854748 5.818282584425053E-6 NRP2, OR10A2, F2RL1, CRP, FASLG, GJA1, DLK1, LY9, LRRC4C, VIPR1, PSG11, APOD, IL1RAP, SEMA3D, CLEC4D, BOC, RAMP3, GPR174, ZP1, SIT1, EGFL6, MFI2, CILP, NTSR2, TXNDC3, SIRPG, HEPACAM, LRP11, MFAP5, CCL1, FGFR2, GCNT3, IL22RA1, LPAL2, PRRG2, CRB2, GPR26, FGFBP1, FETUB, KIR2DS2, PLG, CD1E, LAMA1, OR12D2, GPR34, PNOC, PRLR, STAB1, CLEC7A, MUC17 173 2924 19235 1.9012477957979805 0.0014012275447140565 7.008593742883207E-4 0.0075146335784204155 UP_SEQ_FEATURE disulfide bond 48 26.81564245810056 1.3225119010602557E-5 NRP2, CCL1, FGFR2, GCNT3, IL22RA1, OR10A2, LPAL2, CRP, F2RL1, GJA1, FASLG, DLK1, LRRC4C, LY9, VIPR1, PSG11, APOD, CRB2, PRRG2, GPR26, IL1RAP, SEMA3D, CLEC4D, BOC, FGFBP1, RAMP3, GPR174, ZP1, SIT1, EGFL6, FETUB, MFI2, KIR2DS2, CILP, NTSR2, PLG, CD1E, TXNDC3, LAMA1, SIRPG, OR12D2, GPR34, PRLR, HEPACAM, STAB1, LRP11, CLEC7A, MUC17 173 2819 19113 1.8811737856453012 0.008690652316576508 0.0017442043576424426 0.019785345418288358 SP_PIR_KEYWORDS signal 52 29.05027932960894 2.252815897997887E-5 NRP2, ACVRL1, HFE2, WNT3A, F2RL1, CRP, DLK1, LY9, LRRC4C, VIPR1, PSG11, TLR9, APOD, HPSE, IL1RAP, SEMA3D, BOC, RAMP3, ZP1, SIT1, EGFL6, MFI2, CILP, IL26, SIRPG, HEPACAM, CD34, LRP11, MFAP5, CCL1, FGFR2, IL22RA1, C21ORF63, LPAL2, PRRG2, CRB2, PCSK6, FGFBP1, TMEM92, FETUB, MUC20, KIR2DS2, COL5A3, ECM2, PLG, CD1E, LAMA1, PRLR, PNOC, STAB1, SLC46A3, MUC17 173 3250 19235 1.7789595375722542 0.005414635202070639 0.0010852801512569732 0.029093466063856432 UP_SEQ_FEATURE signal peptide 52 29.05027932960894 2.6839764016354527E-5 NRP2, ACVRL1, HFE2, WNT3A, F2RL1, CRP, DLK1, LY9, LRRC4C, VIPR1, PSG11, TLR9, APOD, HPSE, IL1RAP, SEMA3D, BOC, RAMP3, ZP1, SIT1, EGFL6, MFI2, CILP, IL26, SIRPG, HEPACAM, CD34, LRP11, MFAP5, CCL1, FGFR2, IL22RA1, C21ORF63, LPAL2, PRRG2, CRB2, PCSK6, FGFBP1, TMEM92, FETUB, MUC20, KIR2DS2, COL5A3, ECM2, PLG, CD1E, LAMA1, PRLR, PNOC, STAB1, SLC46A3, MUC17 173 3250 19113 1.7676763005780347 0.017558502929642228 0.002948059575882289 0.0401496224600284 SP_PIR_KEYWORDS Secreted 28 15.64245810055866 0.002186808266671219 FGFR2, CCL1, LPAL2, WNT3A, CRP, FASLG, PSG11, APOD, HPSE, CRB2, IL1RAP, SEMA3D, PCSK6, FGFBP1, ZP1, EGFL6, FETUB, MUC20, CILP, IL26, COL5A3, ECM2, PLG, LAMA1, PNOC, PRLR, MFAP5, MUC17 173 1689 19235 1.8432085202791268 0.409979431281134 0.07260075931257848 2.7879727241797103 GOTERM_CC_FAT GO:0005576~extracellular region 33 18.435754189944134 0.0037509136610672632 CCL1, FGFR2, HFE2, LPAL2, WNT3A, CRP, FASLG, DLK1, PSG11, TLR9, APOD, HPSE, PRRG2, CRB2, IL1RAP, SEMA3D, PCSK6, FGFBP1, ZP1, EGFL6, FETUB, MUC20, MFI2, CILP, IL26, COL5A3, ECM2, PLG, LAMA1, PRLR, PNOC, MFAP5, MUC17 128 2010 12782 1.639482276119403 0.535421650288836 0.22550315019562173 4.6155785665641496 GOTERM_CC_FAT GO:0044421~extracellular region part 18 10.05586592178771 0.014062352220580065 CCL1, ZP1, HFE2, EGFL6, WNT3A, CRP, CILP, FASLG, IL26, DLK1, COL5A3, ECM2, PLG, LAMA1, APOD, PCSK6, MFAP5, FGFBP1 128 960 12782 1.87236328125 0.9443727138916171 0.43887764080092917 16.31274947387379 GOTERM_CC_FAT GO:0005615~extracellular space 13 7.262569832402235 0.03969586197488495 CCL1, HFE2, EGFL6, WNT3A, CRP, CILP, FASLG, IL26, DLK1, PLG, APOD, PCSK6, FGFBP1 128 685 12782 1.8951414233576642 0.9997421333036176 0.5281942763948908 39.91062268383993 Annotation Cluster 3 Enrichment Score: 2.6879406478590906 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051674~localization of cell 10 5.58659217877095 0.0014594762388784684 NRP2, DNAH11, LAMA1, ACVRL1, LMX1B, CD34, AMOT, TBX1, SIX4, SCNN1B 119 307 13528 3.702953494101224 0.7771903582376434 0.13941574114868205 2.2891288081525407 GOTERM_BP_FAT GO:0048870~cell motility 10 5.58659217877095 0.0014594762388784684 NRP2, DNAH11, LAMA1, ACVRL1, LMX1B, CD34, AMOT, TBX1, SIX4, SCNN1B 119 307 13528 3.702953494101224 0.7771903582376434 0.13941574114868205 2.2891288081525407 GOTERM_BP_FAT GO:0016477~cell migration 9 5.027932960893855 0.0028674450287853722 NRP2, LAMA1, ACVRL1, LMX1B, CD34, AMOT, TBX1, SIX4, SCNN1B 119 276 13528 3.7069784435513333 0.9477631877888678 0.21807567807802208 4.45086413519693 GOTERM_BP_FAT GO:0006928~cell motion 12 6.70391061452514 0.002899667827945585 NRP2, DNAH11, LAMA1, HOXA2, DNAH9, ACVRL1, LMX1B, CD34, AMOT, TBX1, SIX4, SCNN1B 119 475 13528 2.8719327731092434 0.9494700298062262 0.2051722831039191 4.4998090789652 Annotation Cluster 4 Enrichment Score: 2.174107457421357 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030247~polysaccharide binding 7 3.910614525139665 0.0034377408129966664 FGFR2, STAB1, CLEC7A, COL5A3, PCSK6, ECM2, FGFBP1 124 154 12983 4.7591642228739 0.651375897333442 0.651375897333442 4.5107670941685445 GOTERM_MF_FAT GO:0001871~pattern binding 7 3.910614525139665 0.0034377408129966664 FGFR2, STAB1, CLEC7A, COL5A3, PCSK6, ECM2, FGFBP1 124 154 12983 4.7591642228739 0.651375897333442 0.651375897333442 4.5107670941685445 GOTERM_MF_FAT GO:0030246~carbohydrate binding 10 5.58659217877095 0.006491319609870876 FGFR2, CD34, STAB1, C21ORF63, CLEC7A, CLEC4D, COL5A3, PCSK6, ECM2, FGFBP1 124 354 12983 2.957672680882085 0.8636893535711163 0.6307972827444471 8.358793810901076 GOTERM_MF_FAT GO:0005539~glycosaminoglycan binding 6 3.35195530726257 0.010630087416647836 FGFR2, STAB1, COL5A3, PCSK6, ECM2, FGFBP1 124 140 12983 4.48721198156682 0.9620018979202234 0.5584900694517327 13.345537338045721 GOTERM_MF_FAT GO:0008201~heparin binding 5 2.793296089385475 0.01652139154757471 FGFR2, COL5A3, PCSK6, ECM2, FGFBP1 124 103 12983 5.082602568117757 0.9938896663292041 0.639244479764443 20.011872212472415 Annotation Cluster 5 Enrichment Score: 1.7758482924763996 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043009~chordate embryonic development 11 6.145251396648044 6.320368773160965E-4 HOXA2, ACVRL1, LMX1B, MEOX2, WNT3A, PRRX1, AMOT, TBX1, ZFPM2, SIX4, DLK1 119 331 13528 3.777907537637412 0.47792254680292434 0.14997101585375827 0.9974237554606247 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 11 6.145251396648044 6.776323266137901E-4 HOXA2, ACVRL1, LMX1B, MEOX2, WNT3A, PRRX1, AMOT, TBX1, ZFPM2, SIX4, DLK1 119 334 13528 3.7439742364011472 0.5018440806121413 0.1300925323073603 1.0690167198688316 GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 7 3.910614525139665 0.01041823327629327 NRP2, ACVRL1, MEOX2, PRRX1, AMOT, TBX1, ZFPM2 119 211 13528 3.7713967103429047 0.9999788975981442 0.4897644161209427 15.299686572420635 GOTERM_BP_FAT GO:0001568~blood vessel development 7 3.910614525139665 0.020366412926036526 NRP2, ACVRL1, MEOX2, PRRX1, AMOT, TBX1, ZFPM2 119 245 13528 3.248019207683073 0.9999999993491974 0.5857838244094485 27.837495438783797 GOTERM_BP_FAT GO:0001944~vasculature development 7 3.910614525139665 0.022623861075370375 NRP2, ACVRL1, MEOX2, PRRX1, AMOT, TBX1, ZFPM2 119 251 13528 3.170377314272322 0.9999999999392619 0.6097540283292215 30.42942231525615 GOTERM_BP_FAT GO:0060021~palate development 3 1.675977653631285 0.031560267969391015 MEOX2, PRRX1, TBX1 119 32 13528 10.657563025210083 0.9999999999999952 0.6547375025541164 39.858170641514015 GOTERM_BP_FAT GO:0001667~ameboidal cell migration 3 1.675977653631285 0.0412053588868556 NRP2, AMOT, TBX1 119 37 13528 9.2173518055871 1.0 0.7198000321556643 48.68391029700506 GOTERM_BP_FAT GO:0001525~angiogenesis 4 2.2346368715083798 0.13918335167092535 NRP2, ACVRL1, MEOX2, TBX1 119 148 13528 3.0724506018623665 1.0 0.892783128057318 90.71059672898012 GOTERM_BP_FAT GO:0007517~muscle organ development 4 2.2346368715083798 0.27968669810439273 MEOX2, TBX1, ZFPM2, SIX4 119 211 13528 2.1550838344816596 1.0 0.9533906500413946 99.44924668105422 Annotation Cluster 6 Enrichment Score: 1.5180199185648247 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS extracellular matrix 8 4.4692737430167595 0.006056631155848914 LAMA1, ZP1, EGFL6, WNT3A, CILP, COL5A3, ECM2, MFAP5 173 241 19235 3.690787422349075 0.7687107791090091 0.15013371786898877 7.546586795250343 GOTERM_MF_FAT GO:0005201~extracellular matrix structural constituent 5 2.793296089385475 0.0089657648451223 LAMA1, WNT3A, COL5A3, MFAP5, MUC17 124 86 12983 6.087303075768942 0.9364480087905714 0.6009355380196305 11.371207111598169 GOTERM_CC_FAT GO:0031012~extracellular matrix 9 5.027932960893855 0.021724776493796297 LAMA1, ZP1, EGFL6, WNT3A, CILP, COL5A3, PCSK6, ECM2, MFAP5 128 345 12782 2.6050271739130433 0.9886745595601086 0.42884118016307826 24.133233094653395 GOTERM_CC_FAT GO:0044420~extracellular matrix part 5 2.793296089385475 0.029174226347883025 LAMA1, EGFL6, CILP, COL5A3, MFAP5 128 117 12782 4.267494658119658 0.9976186419551494 0.4888644618725979 31.086078683236384 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 8 4.4692737430167595 0.04043827499314973 LAMA1, ZP1, EGFL6, WNT3A, CILP, COL5A3, ECM2, MFAP5 128 320 12782 2.4964843749999996 0.9997797707665929 0.47678198386707316 40.49217192629384 GOTERM_MF_FAT GO:0005198~structural molecule activity 7 3.910614525139665 0.5601634031751368 LAMA1, KRT80, WNT3A, COL5A3, TUBB1, MFAP5, MUC17 124 634 12983 1.1560114989315151 1.0 0.9995075772762616 99.99834460082123 Annotation Cluster 7 Enrichment Score: 1.474379702677629 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002292:gap junction protein 3 1.675977653631285 0.004923030149282058 GJA1, GJA3, GJB2 62 13 7396 27.52853598014888 0.27442238558873744 0.27442238558873744 4.905524936695905 INTERPRO IPR019570:Gap junction protein, cysteine-rich domain 3 1.675977653631285 0.013241001689702776 GJA1, GJA3, GJB2 148 20 16659 16.88412162162162 0.9914224931707349 0.9914224931707349 16.709913015236822 INTERPRO IPR000500:Connexins 3 1.675977653631285 0.013241001689702776 GJA1, GJA3, GJB2 148 20 16659 16.88412162162162 0.9914224931707349 0.9914224931707349 16.709913015236822 INTERPRO IPR013092:Connexin, N-terminal 3 1.675977653631285 0.014550919989484545 GJA1, GJA3, GJB2 148 21 16659 16.08011583011583 0.9946616719878849 0.8252293833970663 18.21383324470094 INTERPRO IPR017991:Connexin region 3 1.675977653631285 0.014550919989484545 GJA1, GJA3, GJB2 148 21 16659 16.08011583011583 0.9946616719878849 0.8252293833970663 18.21383324470094 INTERPRO IPR017990:Connexin, conserved site 3 1.675977653631285 0.014550919989484545 GJA1, GJA3, GJB2 148 21 16659 16.08011583011583 0.9946616719878849 0.8252293833970663 18.21383324470094 SMART SM00037:CNX 3 1.675977653631285 0.017308027398017463 GJA1, GJA3, GJB2 89 21 9079 14.573033707865168 0.799367366551921 0.799367366551921 17.365484823620715 GOTERM_CC_FAT GO:0005922~connexon complex 3 1.675977653631285 0.019870860889159007 GJA1, GJA3, GJB2 128 22 12782 13.6171875 0.983335457907717 0.44285211847027384 22.305370974730565 SP_PIR_KEYWORDS gap junction 3 1.675977653631285 0.02084065461372183 GJA1, GJA3, GJB2 173 25 19235 13.342196531791906 0.993753122830747 0.32323854912034555 23.816281780022706 GOTERM_CC_FAT GO:0005921~gap junction 3 1.675977653631285 0.033388654575954385 GJA1, GJA3, GJB2 128 29 12782 10.330280172413794 0.9990196408420526 0.4998059503614303 34.754825426811095 GOTERM_CC_FAT GO:0005911~cell-cell junction 4 2.2346368715083798 0.2925821216948976 GJA1, AMOT, GJA3, GJB2 128 190 12782 2.1023026315789473 1.0 0.9535814300645392 98.71253255769699 SP_PIR_KEYWORDS cell junction 5 2.793296089385475 0.4797403837684815 GJA1, AMOT, SYT6, GJA3, GJB2 173 399 19235 1.3932953771712517 1.0 0.9743248644815438 99.97838780494466 GOTERM_CC_FAT GO:0030054~cell junction 5 2.793296089385475 0.7622364876089731 GJA1, AMOT, SYT6, GJA3, GJB2 128 518 12782 0.963893581081081 1.0 0.9990670719476055 99.99999857019878 Annotation Cluster 8 Enrichment Score: 1.3591650407948381 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005501~retinoid binding 3 1.675977653631285 0.0166214818624048 RBP5, LRAT, APOD 124 21 12983 14.9573732718894 0.9940770321485243 0.5746400829968832 20.120913892416002 GOTERM_MF_FAT GO:0019840~isoprenoid binding 3 1.675977653631285 0.019780367498717935 RBP5, LRAT, APOD 124 23 12983 13.656732117812062 0.9977871123665311 0.5342853280597737 23.492451066407117 GOTERM_MF_FAT GO:0008289~lipid binding 7 3.910614525139665 0.254449019395847 RBP5, MCTP2, LRAT, APOD, SDPR, FABP3, SCP2 124 450 12983 1.6286917562724015 1.0 0.9888081111050141 98.04670925326039 Annotation Cluster 9 Enrichment Score: 1.3464434059215964 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042472~inner ear morphogenesis 5 2.793296089385475 0.001424233648433451 MYO15A, WNT3A, PRRX1, TBX1, SIX4 119 56 13528 10.150060024009603 0.7689580077910998 0.15023470312298692 2.2344355481697997 GOTERM_BP_FAT GO:0048839~inner ear development 5 2.793296089385475 0.004998183542223435 MYO15A, WNT3A, PRRX1, TBX1, SIX4 119 79 13528 7.194979257525795 0.9942064861806589 0.29064635751857715 7.637256408656445 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 5 2.793296089385475 0.19204461723477534 WNT3A, BCL11A, PTPN22, TBX1, SIX4 119 260 13528 2.1861667744020687 1.0 0.9287241388775831 96.59907158752496 GOTERM_BP_FAT GO:0002520~immune system development 5 2.793296089385475 0.2209731835528662 WNT3A, BCL11A, PTPN22, TBX1, SIX4 119 276 13528 2.05943246863963 1.0 0.9459077627811678 98.09221689402425 GOTERM_BP_FAT GO:0030097~hemopoiesis 3 1.675977653631285 0.6132644875947834 WNT3A, BCL11A, PTPN22 119 236 13528 1.4450932915539099 1.0 0.9946063785165677 99.99997127110977 Annotation Cluster 10 Enrichment Score: 1.3378208583841087 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007389~pattern specification process 7 3.910614525139665 0.02945449243634944 DNAH11, HOXA2, LMX1B, MEOX2, WNT3A, TBX1, NKX6-1 119 267 13528 2.980392156862745 0.999999999999955 0.653473723601349 37.75090651541861 GOTERM_BP_FAT GO:0007368~determination of left/right symmetry 3 1.675977653631285 0.05180200669528533 DNAH11, WNT3A, TBX1 119 42 13528 8.120048019207683 1.0 0.7364970496926485 56.97441168501546 GOTERM_BP_FAT GO:0009799~determination of symmetry 3 1.675977653631285 0.05402679684458629 DNAH11, WNT3A, TBX1 119 43 13528 7.931209693179597 1.0 0.7349450922125405 58.54744928006683 GOTERM_BP_FAT GO:0009855~determination of bilateral symmetry 3 1.675977653631285 0.05402679684458629 DNAH11, WNT3A, TBX1 119 43 13528 7.931209693179597 1.0 0.7349450922125405 58.54744928006683 Annotation Cluster 11 Enrichment Score: 1.2850837208727524 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Immunoglobulin domain 12 6.70391061452514 0.003435711785122641 FGFR2, SIRPG, HEPACAM, IL1RAP, SEMA3D, KIR2DS2, CILP, LY9, LRRC4C, BOC, PSG11, CD1E 173 470 19235 2.8387652195301927 0.5637030556843966 0.09848538564232756 4.347854650031202 INTERPRO IPR007110:Immunoglobulin-like 11 6.145251396648044 0.013470531170090295 FGFR2, SIRPG, HEPACAM, IL1RAP, SEMA3D, CILP, LY9, LRRC4C, BOC, PSG11, CD1E 148 501 16659 2.4713950477423534 0.9921060862265483 0.9111523001228974 16.975275258983345 INTERPRO IPR003599:Immunoglobulin subtype 8 4.4692737430167595 0.02724080170237339 SIRPG, HEPACAM, IL1RAP, SEMA3D, KIR2DS2, LY9, BOC, PSG11 148 330 16659 2.728746928746929 0.9999477713777603 0.9149886050842544 31.534978060020347 UP_SEQ_FEATURE domain:Ig-like C2-type 1 6 3.35195530726257 0.02893398636165885 FGFR2, IL1RAP, KIR2DS2, LY9, BOC, PSG11 173 190 19113 3.4888348037724364 0.9999999961613548 0.8838795624135799 35.550688188150545 UP_SEQ_FEATURE domain:Ig-like C2-type 2 6 3.35195530726257 0.029370578306958998 FGFR2, IL1RAP, KIR2DS2, LY9, BOC, PSG11 173 191 19113 3.470568652967345 0.9999999971471563 0.8601933597603976 35.98287032817912 INTERPRO IPR013151:Immunoglobulin 6 3.35195530726257 0.033511950819063406 FGFR2, HEPACAM, KIR2DS2, CILP, BOC, PSG11 148 202 16659 3.3433904201230935 0.999994810251542 0.8684196457136792 37.34734031222875 INTERPRO IPR003598:Immunoglobulin subtype 2 6 3.35195530726257 0.03536646048515464 FGFR2, HEPACAM, CILP, LRRC4C, BOC, PSG11 148 205 16659 3.2944627554383654 0.9999973856617684 0.7994742165710531 38.97641671621859 SMART SM00409:IG 8 4.4692737430167595 0.04060667091864538 SIRPG, HEPACAM, IL1RAP, SEMA3D, KIR2DS2, LY9, BOC, PSG11 89 330 9079 2.472999659516513 0.9779354089543837 0.8514584534696898 36.42052105876395 SMART SM00408:IGc2 6 3.35195530726257 0.048580435944951976 FGFR2, HEPACAM, CILP, LRRC4C, BOC, PSG11 89 205 9079 2.985694710879693 0.9897616225253448 0.7828580605786976 41.96117043929133 INTERPRO IPR013783:Immunoglobulin-like fold 10 5.58659217877095 0.056523100622139937 FGFR2, SIRPG, HEPACAM, IL1RAP, KIR2DS2, CILP, LRRC4C, BOC, PSG11, CD1E 148 553 16659 2.0354577000146623 0.9999999990470638 0.848673533979049 54.98185232658914 UP_SEQ_FEATURE domain:Ig-like C2-type 4 2.2346368715083798 0.06603782796164542 HEPACAM, SEMA3D, CILP, LRRC4C 173 103 19113 4.290476457713677 1.0 0.9688368967032914 64.01906751899236 INTERPRO IPR013106:Immunoglobulin V-set 5 2.793296089385475 0.17818254196322503 SIRPG, HEPACAM, SEMA3D, BOC, PSG11 148 249 16659 2.260257245197004 1.0 0.9460137051737497 93.2240604625302 UP_SEQ_FEATURE domain:Ig-like C2-type 3 3 1.675977653631285 0.30046250393826457 FGFR2, IL1RAP, BOC 173 122 19113 2.716715625888373 1.0 0.9999867373175649 99.52346851528006 UP_SEQ_FEATURE domain:Ig-like V-type 3 1.675977653631285 0.3071010173202373 SIRPG, HEPACAM, PSG11 173 124 19113 2.672897631922431 1.0 0.9999834003966371 99.58682538642805 INTERPRO IPR013098:Immunoglobulin I-set 3 1.675977653631285 0.3443471870188183 FGFR2, LRRC4C, BOC 148 138 16659 2.4469741480611047 1.0 0.9934170621785405 99.69429158177101 Annotation Cluster 12 Enrichment Score: 1.251096273317265 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044459~plasma membrane part 31 17.318435754189945 0.04006481124090806 ACVRL1, HFE2, MYO7B, F2RL1, GJA1, FASLG, SYT6, VIPR1, GJA3, PRRG2, SDPR, IL1RAP, RASA3, SCNN1B, RAMP3, SIT1, MUC20, MFI2, KIR2DS2, RHD, NTSR2, CD1E, GJB2, CYBA, GPR34, HEPACAM, CD34, STAB1, SLC17A2, AMOT, CLEC7A 128 2203 12782 1.4051932024512028 0.9997615759473192 0.5009862580567557 40.20027987415327 GOTERM_CC_FAT GO:0031226~intrinsic to plasma membrane 19 10.614525139664805 0.055325517785329605 RAMP3, SIT1, ACVRL1, F2RL1, MFI2, KIR2DS2, RHD, FASLG, GJA1, VIPR1, NTSR2, CD1E, CYBA, GPR34, PRRG2, STAB1, IL1RAP, SLC17A2, RASA3 128 1215 12782 1.5615869341563786 0.9999909308708724 0.5388547859666295 51.114128810415394 GOTERM_CC_FAT GO:0005887~integral to plasma membrane 18 10.05586592178771 0.07962007676052367 RAMP3, SIT1, ACVRL1, F2RL1, MFI2, KIR2DS2, RHD, FASLG, GJA1, VIPR1, NTSR2, CD1E, CYBA, GPR34, PRRG2, STAB1, IL1RAP, SLC17A2 128 1188 12782 1.5130208333333333 0.9999999554040043 0.6527989806532034 64.77093123936315 Annotation Cluster 13 Enrichment Score: 1.2174299226227028 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR012680:Laminin G, subdomain 2 3 1.675977653631285 0.052926315040625185 LAMA1, CRB2, COL5A3 148 42 16659 8.040057915057915 0.9999999962931436 0.884329433619482 52.569792607395804 INTERPRO IPR001791:Laminin G 3 1.675977653631285 0.05983291391412328 LAMA1, CRB2, COL5A3 148 45 16659 7.504054054054055 0.9999999997282307 0.8162745752372755 57.10049534661162 SMART SM00282:LamG 3 1.675977653631285 0.07032316695903304 LAMA1, CRB2, COL5A3 89 45 9079 6.800749063670412 0.998779480268043 0.8130884231989237 54.91494431452119 Annotation Cluster 14 Enrichment Score: 1.209888783080337 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042471~ear morphogenesis 7 3.910614525139665 2.298720496792706E-5 HOXA2, MYO15A, WNT3A, PRRX1, TBX1, SIX4, MYC 119 66 13528 12.057040998217468 0.02335408989265242 0.02335408989265242 0.03644072083194283 GOTERM_BP_FAT GO:0042474~middle ear morphogenesis 4 2.2346368715083798 1.736000879747805E-4 HOXA2, PRRX1, TBX1, MYC 119 13 13528 34.97866839043309 0.16345618640298665 0.08537230875234625 0.27489381752867637 GOTERM_BP_FAT GO:0043583~ear development 7 3.910614525139665 1.7909444217619012E-4 HOXA2, MYO15A, WNT3A, PRRX1, TBX1, SIX4, MYC 119 95 13528 8.376470588235295 0.16816865993853747 0.05952968304701711 0.28358249698599014 GOTERM_BP_FAT GO:0043009~chordate embryonic development 11 6.145251396648044 6.320368773160965E-4 HOXA2, ACVRL1, LMX1B, MEOX2, WNT3A, PRRX1, AMOT, TBX1, ZFPM2, SIX4, DLK1 119 331 13528 3.777907537637412 0.47792254680292434 0.14997101585375827 0.9974237554606247 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 11 6.145251396648044 6.776323266137901E-4 HOXA2, ACVRL1, LMX1B, MEOX2, WNT3A, PRRX1, AMOT, TBX1, ZFPM2, SIX4, DLK1 119 334 13528 3.7439742364011472 0.5018440806121413 0.1300925323073603 1.0690167198688316 GOTERM_BP_FAT GO:0048568~embryonic organ development 8 4.4692737430167595 7.672705553203844E-4 HOXA2, MYO15A, WNT3A, PRRX1, TBX1, ZFPM2, SIX4, MYC 119 172 13528 5.287473128786398 0.5457269725496862 0.12322903663909468 1.2096232846190214 GOTERM_BP_FAT GO:0007423~sensory organ development 9 5.027932960893855 8.836627145059091E-4 HOXA2, LMX1B, MYO15A, WNT3A, PRRX1, FASLG, TBX1, SIX4, MYC 119 229 13528 4.467799346812961 0.5969952252328548 0.12175488734662798 1.3919166872327415 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 7 3.910614525139665 0.001080876989230423 HOXA2, MYO15A, WNT3A, PRRX1, TBX1, SIX4, MYC 119 133 13528 5.983193277310924 0.6710147893495965 0.12974395863095456 1.7000744580533467 GOTERM_BP_FAT GO:0042472~inner ear morphogenesis 5 2.793296089385475 0.001424233648433451 MYO15A, WNT3A, PRRX1, TBX1, SIX4 119 56 13528 10.150060024009603 0.7689580077910998 0.15023470312298692 2.2344355481697997 GOTERM_BP_FAT GO:0006928~cell motion 12 6.70391061452514 0.002899667827945585 NRP2, DNAH11, LAMA1, HOXA2, DNAH9, ACVRL1, LMX1B, CD34, AMOT, TBX1, SIX4, SCNN1B 119 475 13528 2.8719327731092434 0.9494700298062262 0.2051722831039191 4.4998090789652 GOTERM_BP_FAT GO:0048706~embryonic skeletal system development 5 2.793296089385475 0.004562016036476994 HOXA2, PRRX1, TBX1, SIX4, DLK1 119 77 13528 7.381861835643349 0.9909091102619297 0.2851973222955123 6.993212000636262 GOTERM_BP_FAT GO:0048839~inner ear development 5 2.793296089385475 0.004998183542223435 MYO15A, WNT3A, PRRX1, TBX1, SIX4 119 79 13528 7.194979257525795 0.9942064861806589 0.29064635751857715 7.637256408656445 GOTERM_BP_FAT GO:0048701~embryonic cranial skeleton morphogenesis 3 1.675977653631285 0.010536150980953065 HOXA2, PRRX1, TBX1 119 18 13528 18.946778711484594 0.9999813306343647 0.47297508040963676 15.459569815780016 GOTERM_BP_FAT GO:0048704~embryonic skeletal system morphogenesis 4 2.2346368715083798 0.013448810941140346 HOXA2, PRRX1, TBX1, SIX4 119 57 13528 7.977591036414566 0.9999990984831704 0.5385068987397533 19.32020657566438 GOTERM_BP_FAT GO:0048705~skeletal system morphogenesis 5 2.793296089385475 0.01660878070881236 HOXA2, PRRX1, TBX1, SIX4, MYC 119 112 13528 5.0750300120048015 0.9999999666831998 0.5595097024451738 23.32150287511048 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 8 4.4692737430167595 0.01796817468577321 HOXA2, MYO15A, WNT3A, PRRX1, AMOT, TBX1, SIX4, MYC 119 307 13528 2.9623627952809786 0.9999999919632915 0.5714031155463848 24.984968961812704 UP_SEQ_FEATURE DNA-binding region:Homeobox 6 3.35195530726257 0.02893398636165885 HOXA2, LMX1B, MEOX2, PRRX1, SIX4, NKX6-1 173 190 19113 3.4888348037724364 0.9999999961613548 0.8838795624135799 35.550688188150545 GOTERM_BP_FAT GO:0003002~regionalization 6 3.35195530726257 0.02907229569020782 HOXA2, LMX1B, MEOX2, WNT3A, TBX1, NKX6-1 119 197 13528 3.4623555005758653 0.9999999999999327 0.6614865399146438 37.36109935761587 GOTERM_BP_FAT GO:0007389~pattern specification process 7 3.910614525139665 0.02945449243634944 DNAH11, HOXA2, LMX1B, MEOX2, WNT3A, TBX1, NKX6-1 119 267 13528 2.980392156862745 0.999999999999955 0.653473723601349 37.75090651541861 GOTERM_BP_FAT GO:0007605~sensory perception of sound 4 2.2346368715083798 0.052860957421880135 MYO15A, TBX1, MYC, GJB2 119 97 13528 4.68786277397557 1.0 0.7353339777662977 57.72999011152348 INTERPRO IPR017970:Homeobox, conserved site 6 3.35195530726257 0.05490321512542266 HOXA2, LMX1B, MEOX2, PRRX1, SIX4, NKX6-1 148 232 16659 2.911055452003728 0.9999999982419387 0.8668002526800419 53.909966569354296 INTERPRO IPR001356:Homeobox 6 3.35195530726257 0.057393871620996934 HOXA2, LMX1B, MEOX2, PRRX1, SIX4, NKX6-1 148 235 16659 2.8738930419781483 0.9999999993146657 0.8276841583807213 55.54844900200449 INTERPRO IPR012287:Homeodomain-related 6 3.35195530726257 0.05994873644566211 HOXA2, LMX1B, MEOX2, PRRX1, SIX4, NKX6-1 148 238 16659 2.8376674994322055 0.9999999997399248 0.7932887056417011 57.172932403280186 GOTERM_BP_FAT GO:0050954~sensory perception of mechanical stimulus 4 2.2346368715083798 0.0611095053644197 MYO15A, TBX1, MYC, GJB2 119 103 13528 4.414783389083789 1.0 0.755654979820211 63.203948606567465 GOTERM_BP_FAT GO:0035282~segmentation 3 1.675977653631285 0.06563675600772634 HOXA2, MEOX2, WNT3A 119 48 13528 7.105042016806722 1.0 0.773478016763826 65.91857141820951 SP_PIR_KEYWORDS Homeobox 6 3.35195530726257 0.06656694429672463 HOXA2, LMX1B, MEOX2, PRRX1, SIX4, NKX6-1 173 242 19235 2.7566521759900633 0.999999938334034 0.5464043978556037 58.92341855541634 GOTERM_BP_FAT GO:0001701~in utero embryonic development 5 2.793296089385475 0.06805228696670121 ACVRL1, LMX1B, WNT3A, AMOT, ZFPM2 119 176 13528 3.229564553093965 1.0 0.7789609713846201 67.28904222435172 SMART SM00389:HOX 6 3.35195530726257 0.07760220605807776 HOXA2, LMX1B, MEOX2, PRRX1, SIX4, NKX6-1 89 235 9079 2.604542194597179 0.9994077848467634 0.7737982798820142 58.62500626543672 SP_PIR_KEYWORDS developmental protein 12 6.70391061452514 0.09077219739135045 NRP2, TXNDC3, HOXA2, LMX1B, MEOX2, EGFL6, WNT3A, SEMA3D, PRRX1, MAEL, SIX4, NKX6-1 173 779 19235 1.7127338294983192 0.9999999998903213 0.615403700050823 70.74388424083435 GOTERM_BP_FAT GO:0009953~dorsal/ventral pattern formation 3 1.675977653631285 0.09638103375290215 HOXA2, LMX1B, NKX6-1 119 60 13528 5.684033613445378 1.0 0.8599504727406458 79.94911436760493 GOTERM_BP_FAT GO:0045165~cell fate commitment 4 2.2346368715083798 0.12156269042796028 HOXA2, WNT3A, TBX1, NKX6-1 119 139 13528 3.271386252342664 1.0 0.8834027511973441 87.19096417894245 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 4 2.2346368715083798 0.12347755704765224 HOXA2, MEOX2, WNT3A, TBX1 119 140 13528 3.248019207683073 1.0 0.8835771612915125 87.62657762740173 GOTERM_BP_FAT GO:0001501~skeletal system development 6 3.35195530726257 0.14650588465121747 HOXA2, PRRX1, TBX1, SIX4, DLK1, MYC 119 319 13528 2.138194462738073 1.0 0.9023593511666882 91.8873529588699 GOTERM_MF_FAT GO:0043565~sequence-specific DNA binding 9 5.027932960893855 0.21764955784962348 HOXA2, LMX1B, MEOX2, PRRX1, TBX1, SIX4, MYC, FOXR1, NKX6-1 124 607 12983 1.5524127119094437 1.0 0.9845892899319427 96.27420640173436 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 6 3.35195530726257 0.22328090294509617 HOXA2, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 371 13528 1.8385014383111735 1.0 0.9459883609608728 98.17987749277577 GOTERM_BP_FAT GO:0007517~muscle organ development 4 2.2346368715083798 0.27968669810439273 MEOX2, TBX1, ZFPM2, SIX4 119 211 13528 2.1550838344816596 1.0 0.9533906500413946 99.44924668105422 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 9 5.027932960893855 0.30104149882946507 IKZF3, HOXA2, LMX1B, MAEL, TBX1, ZFPM2, SIX4, MYC, NKX6-1 119 727 13528 1.407326066602707 1.0 0.9570167346460126 99.65823511797315 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 8 4.4692737430167595 0.3449060065483879 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC, TLR9 119 654 13528 1.390589263228227 1.0 0.9682845569030561 99.87769744130614 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 7 3.910614525139665 0.36950279147161713 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 564 13528 1.41093032957864 1.0 0.9732053513082336 99.93333267285585 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 8 4.4692737430167595 0.3894864891886165 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC, TLR9 119 685 13528 1.327657486352205 1.0 0.9753434413333696 99.95999349356728 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 7 3.910614525139665 0.3961995104101173 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 581 13528 1.3696466538422598 1.0 0.9766753542729204 99.96642652691192 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 6 3.35195530726257 0.40318089099023696 HOXA2, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 477 13528 1.4299455631309128 1.0 0.9767876797288877 99.97208001564987 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 8 4.4692737430167595 0.40393068163317747 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC, TLR9 119 695 13528 1.3085545009370654 1.0 0.9763802556542497 99.97263100020152 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 6 3.35195530726257 0.4101288027339316 HOXA2, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 481 13528 1.418054123936477 1.0 0.9769080262566906 99.9768109750501 GOTERM_MF_FAT GO:0003700~transcription factor activity 11 6.145251396648044 0.44507527653231005 IKZF3, HOXA2, TAF5L, LMX1B, MEOX2, PRRX1, TBX1, SIX4, MYC, FOXR1, NKX6-1 124 975 12983 1.181248966087676 1.0 0.9987372438025112 99.96268571818001 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7 3.910614525139665 0.46337421729717443 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 624 13528 1.27526395173454 1.0 0.9847357520793945 99.99482564316146 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 9 5.027932960893855 0.47428441070808425 HOXA2, ACVRL1, LMX1B, GJA1, TBX1, ZFPM2, SIX4, MYC, TLR9 119 857 13528 1.1938460331623897 1.0 0.9859412208154508 99.99626391995598 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 7 3.910614525139665 0.4940692104997613 HOXA2, ACVRL1, LMX1B, TBX1, ZFPM2, SIX4, MYC 119 644 13528 1.2356594811837778 1.0 0.9867487402213928 99.99796637617915 GOTERM_MF_FAT GO:0030528~transcription regulator activity 15 8.379888268156424 0.57871919420444 IKZF3, LMX1B, PRRX1, FHL5, ADH1A, TBX1, SIX4, NKX6-1, FOXR1, TAF5L, HOXA2, MEOX2, BCL11A, ZFPM2, MYC 124 1512 12983 1.0387064772145418 1.0 0.9992145722088508 99.99907104251555 GOTERM_BP_FAT GO:0008283~cell proliferation 4 2.2346368715083798 0.7376179141017054 LMX1B, WNT3A, TBX1, MYC 119 436 13528 1.04294194742117 1.0 0.9988199945675277 99.99999993876256 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 14 7.82122905027933 0.7885161866235281 IKZF3, LMX1B, HMGB4, MAEL, PRRX1, TBX1, SIX4, NKX6-1, FOXR1, HOXA2, MEOX2, YEATS2, ZFPM2, MYC 119 1773 13528 0.8976477223715205 1.0 0.9995199710518438 99.99999999799527 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 14 7.82122905027933 0.8143210292846177 IKZF3, LMX1B, HMGB4, MAEL, PRRX1, TBX1, SIX4, NKX6-1, FOXR1, HOXA2, MEOX2, YEATS2, ZFPM2, MYC 119 1813 13528 0.8778430291035334 1.0 0.9997043104077917 99.99999999974531 SP_PIR_KEYWORDS activator 4 2.2346368715083798 0.847538643902991 LMX1B, ZFPM2, MYC, NKX6-1 173 520 19235 0.8552690084481992 1.0 0.9992496532439451 99.99999999718362 SP_PIR_KEYWORDS dna-binding 14 7.82122905027933 0.863515230317496 IKZF3, LMX1B, HMGB4, MAEL, PRRX1, ZNF366, TBX1, SIX4, NKX6-1, FOXR1, HOXA2, MEOX2, ZFPM2, MYC 173 1868 19235 0.8332920746122712 1.0 0.9994465843867129 99.99999999932587 GOTERM_BP_FAT GO:0045449~regulation of transcription 19 10.614525139664805 0.8908330070312778 IKZF3, ACVRL1, HMGB4, LMX1B, PRRX1, MAEL, ZNF366, TBX1, SIX4, NKX6-1, FOXR1, CNOT4, TAF5L, HOXA2, MEOX2, BCL11A, YEATS2, ZFPM2, MYC 119 2601 13528 0.8304239804341574 1.0 0.9999664570401641 99.99999999999994 SP_PIR_KEYWORDS transcription regulation 13 7.262569832402235 0.9573479849989943 IKZF3, LMX1B, TBX1, ZNF366, NKX6-1, FOXR1, CNOT4, TAF5L, HOXA2, MEOX2, BCL11A, ZFPM2, MYC 173 2026 19235 0.7134277513709065 1.0 0.99997763787187 100.0 SP_PIR_KEYWORDS Transcription 12 6.70391061452514 0.9822062488579915 IKZF3, HOXA2, TAF5L, LMX1B, BCL11A, ZNF366, TBX1, ZFPM2, MYC, FOXR1, NKX6-1, CNOT4 173 2071 19235 0.6442393303617531 1.0 0.9999976147919134 100.0 GOTERM_MF_FAT GO:0003677~DNA binding 15 8.379888268156424 0.9831319612190567 IKZF3, LMX1B, HMGB4, MAEL, PRRX1, ZNF366, TBX1, SIX4, NKX6-1, FOXR1, TAF5L, HOXA2, MEOX2, ZFPM2, MYC 124 2331 12983 0.6737555527878109 1.0 0.9999999708240832 100.0 GOTERM_BP_FAT GO:0006350~transcription 11 6.145251396648044 0.9920261025269854 IKZF3, HOXA2, TAF5L, LMX1B, BCL11A, ZNF366, TBX1, ZFPM2, MYC, FOXR1, CNOT4 119 2101 13528 0.5951867658057988 1.0 0.999999998672248 100.0 SP_PIR_KEYWORDS nucleus 23 12.849162011173185 0.9994797031157029 IKZF3, HMGB4, LMX1B, PRRX1, MAEL, ZNF366, FHL5, TBX1, NAV3, NAP1L2, SIX4, NKX6-1, FOXR1, CNOT4, TAF5L, HOXA2, MEOX2, BCL11A, YEATS2, ZFPM2, MAGEA11, MYC, WDR33 173 4283 19235 0.5970708230819789 1.0 0.999999999903952 100.0 Annotation Cluster 15 Enrichment Score: 1.1840311793176193 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000566:Lipocalin-related protein and Bos/Can/Equ allergen 3 1.675977653631285 0.03227111670234593 RBP5, APOD, FABP3 148 32 16659 10.552576013513514 0.99999179512224 0.9038798537284013 36.23492729114409 INTERPRO IPR012674:Calycin 3 1.675977653631285 0.03415794120374469 RBP5, APOD, FABP3 148 33 16659 10.232800982800985 0.9999959122674495 0.830092800411667 37.91932566638272 GOTERM_MF_FAT GO:0008289~lipid binding 7 3.910614525139665 0.254449019395847 RBP5, MCTP2, LRAT, APOD, SDPR, FABP3, SCP2 124 450 12983 1.6286917562724015 1.0 0.9888081111050141 98.04670925326039 Annotation Cluster 16 Enrichment Score: 1.1815260486373171 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction 7 3.910614525139665 0.03521478179759291 CCL1, IL22RA1, ACVRL1, PRLR, IL1RAP, IL26, FASLG 49 262 5085 2.7726281352235547 0.9295522016798363 0.9295522016798363 31.28676924250582 GOTERM_MF_FAT GO:0019955~cytokine binding 4 2.2346368715083798 0.0847465569140905 IL22RA1, ACVRL1, PRLR, IL1RAP 124 109 12983 3.842261023971589 0.9999999999982953 0.8556541643822699 69.48419480691909 GOTERM_MF_FAT GO:0004896~cytokine receptor activity 3 1.675977653631285 0.09562573575409598 IL22RA1, PRLR, IL1RAP 124 55 12983 5.71099706744868 0.9999999999999561 0.8713223322237731 74.00326659676016 Annotation Cluster 17 Enrichment Score: 1.1708374372618928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030334~regulation of cell migration 6 3.35195530726257 0.016190970926620786 LAMA1, ACVRL1, F2RL1, AMOT, ARHGAP8, PLG 119 169 13528 4.036000198896127 0.999999948440753 0.5678690938633192 22.803333349683584 GOTERM_BP_FAT GO:0010594~regulation of endothelial cell migration 3 1.675977653631285 0.019856564581643758 ACVRL1, AMOT, PLG 119 25 13528 13.641680672268908 0.99999999888892 0.5919770608920654 27.23971247703336 GOTERM_BP_FAT GO:0040012~regulation of locomotion 6 3.35195530726257 0.026408899012526577 LAMA1, ACVRL1, F2RL1, AMOT, ARHGAP8, PLG 119 192 13528 3.552521008403361 0.999999999998875 0.6529208918969609 34.58049799070084 GOTERM_BP_FAT GO:0051270~regulation of cell motion 6 3.35195530726257 0.026928531168837245 LAMA1, ACVRL1, F2RL1, AMOT, ARHGAP8, PLG 119 193 13528 3.5341141638002354 0.9999999999993502 0.646310708452049 35.131915734587274 GOTERM_BP_FAT GO:0030335~positive regulation of cell migration 3 1.675977653631285 0.18209011216295415 F2RL1, AMOT, ARHGAP8 119 89 13528 3.831932773109244 1.0 0.9195317552483326 95.87031112185703 GOTERM_BP_FAT GO:0051272~positive regulation of cell motion 3 1.675977653631285 0.21059324012535563 F2RL1, AMOT, ARHGAP8 119 98 13528 3.4800205796604358 1.0 0.9407911266060045 97.64672741863875 GOTERM_BP_FAT GO:0040017~positive regulation of locomotion 3 1.675977653631285 0.21059324012535563 F2RL1, AMOT, ARHGAP8 119 98 13528 3.4800205796604358 1.0 0.9407911266060045 97.64672741863875 GOTERM_BP_FAT GO:0042060~wound healing 4 2.2346368715083798 0.23280125580384586 ACVRL1, F2RL1, SCNN1B, PLG 119 191 13528 2.3807470632231946 1.0 0.9465683029755083 98.50315112407999 Annotation Cluster 18 Enrichment Score: 1.1672641742033705 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007155~cell adhesion 12 6.70391061452514 0.041915237800561014 NRP2, LAMA1, SIRPG, HEPACAM, EGFL6, CD34, STAB1, LY9, CLEC7A, COL5A3, ECM2, BOC 119 700 13528 1.948811524609844 1.0 0.7156803036002959 49.28301184624413 GOTERM_BP_FAT GO:0022610~biological adhesion 12 6.70391061452514 0.04227722714888777 NRP2, LAMA1, SIRPG, HEPACAM, EGFL6, CD34, STAB1, LY9, CLEC7A, COL5A3, ECM2, BOC 119 701 13528 1.946031479638931 1.0 0.6988581906778153 49.58598342047157 SP_PIR_KEYWORDS cell adhesion 7 3.910614525139665 0.1777170303729857 LAMA1, SIRPG, HEPACAM, EGFL6, CD34, LY9, BOC 173 422 19235 1.8443004684546478 1.0 0.8033030327799271 92.01242384749078 Annotation Cluster 19 Enrichment Score: 1.1489207685394462 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046649~lymphocyte activation 6 3.35195530726257 0.030183626397634552 LAT2, PRLR, BCL11A, KIR2DS2, PTPN22, CLEC7A 119 199 13528 3.4275579578565094 0.9999999999999792 0.6501402764055624 38.48826321405648 GOTERM_BP_FAT GO:0002429~immune response-activating cell surface receptor signaling pathway 3 1.675977653631285 0.045335460162996805 LAT2, PTPN22, CLEC7A 119 39 13528 8.744667097608275 1.0 0.7149566702006604 52.078776093702494 GOTERM_BP_FAT GO:0002253~activation of immune response 4 2.2346368715083798 0.04895451994447274 LAT2, CRP, PTPN22, CLEC7A 119 94 13528 4.837475415698194 1.0 0.7336772580650893 54.87944135942313 GOTERM_BP_FAT GO:0002768~immune response-regulating cell surface receptor signaling pathway 3 1.675977653631285 0.05180200669528533 LAT2, PTPN22, CLEC7A 119 42 13528 8.120048019207683 1.0 0.7364970496926485 56.97441168501546 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 6 3.35195530726257 0.05729767356891295 SIRPG, LAT2, CRP, F2RL1, PTPN22, CLEC7A 119 238 13528 2.8658993008968294 1.0 0.7480600849676986 60.762546563264685 GOTERM_BP_FAT GO:0045321~leukocyte activation 6 3.35195530726257 0.060675459062090376 LAT2, PRLR, BCL11A, KIR2DS2, PTPN22, CLEC7A 119 242 13528 2.8185290645183696 1.0 0.7606744536093888 62.93331035841976 GOTERM_BP_FAT GO:0002757~immune response-activating signal transduction 3 1.675977653631285 0.07546516526119991 LAT2, PTPN22, CLEC7A 119 52 13528 6.558500323206205 1.0 0.807210087338633 71.17941613482144 GOTERM_BP_FAT GO:0002764~immune response-regulating signal transduction 3 1.675977653631285 0.0857268983230755 LAT2, PTPN22, CLEC7A 119 56 13528 6.0900360144057615 1.0 0.8299794835294321 75.85391541470025 GOTERM_BP_FAT GO:0042110~T cell activation 4 2.2346368715083798 0.09773784972263706 PRLR, BCL11A, PTPN22, CLEC7A 119 126 13528 3.60891023075897 1.0 0.8588542839067776 80.42118508355252 GOTERM_BP_FAT GO:0001775~cell activation 6 3.35195530726257 0.10623001827959593 LAT2, PRLR, BCL11A, KIR2DS2, PTPN22, CLEC7A 119 287 13528 2.3765994202559075 1.0 0.863378603920955 83.14731860343537 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 4 2.2346368715083798 0.1332151347152784 LAT2, CRP, PTPN22, CLEC7A 119 145 13528 3.136018545349174 1.0 0.8921247622247878 89.63512035657384 GOTERM_BP_FAT GO:0048584~positive regulation of response to stimulus 5 2.793296089385475 0.15126019297728055 LAT2, CRP, F2RL1, PTPN22, CLEC7A 119 236 13528 2.4084888192565166 1.0 0.9006907142942195 92.57496980386037 Annotation Cluster 20 Enrichment Score: 1.1477656121505404 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR019748:FERM central domain 3 1.675977653631285 0.06459974560471263 MYO7B, MYO15A, FRMPD2 148 47 16659 7.1847326049453715 0.9999999999557307 0.795948349627458 59.98976720449777 INTERPRO IPR000299:FERM domain 3 1.675977653631285 0.06459974560471263 MYO7B, MYO15A, FRMPD2 148 47 16659 7.1847326049453715 0.9999999999557307 0.795948349627458 59.98976720449777 INTERPRO IPR019749:Band 4.1 domain 3 1.675977653631285 0.07197890888720003 MYO7B, MYO15A, FRMPD2 148 50 16659 6.7536486486486496 0.9999999999973809 0.7916877656580529 64.10868183558887 INTERPRO IPR019747:FERM conserved site 3 1.675977653631285 0.07197890888720003 MYO7B, MYO15A, FRMPD2 148 50 16659 6.7536486486486496 0.9999999999973809 0.7916877656580529 64.10868183558887 SMART SM00295:B41 3 1.675977653631285 0.08439171366500253 MYO7B, MYO15A, FRMPD2 89 50 9079 6.120674157303371 0.9996998808367482 0.7412488504971557 61.833250260803666 Annotation Cluster 21 Enrichment Score: 1.1129903570868485 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005319~lipid transporter activity 4 2.2346368715083798 0.021821636331833434 APOD, ATP11B, FABP3, ATP11A 124 63 12983 6.647721454173068 0.9988307051321569 0.5277045272462608 25.60056675155358 GOTERM_BP_FAT GO:0006869~lipid transport 4 2.2346368715083798 0.1332151347152784 ATP11B, FABP3, ATP11A, SCP2 119 145 13528 3.136018545349174 1.0 0.8921247622247878 89.63512035657384 GOTERM_BP_FAT GO:0010876~lipid localization 4 2.2346368715083798 0.157611552404641 ATP11B, FABP3, ATP11A, SCP2 119 157 13528 2.8963228603543327 1.0 0.8987156832047546 93.40863297918061 Annotation Cluster 22 Enrichment Score: 1.001468438515267 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018029:C2 membrane targeting protein 4 2.2346368715083798 0.06740367967740109 MCTP2, HECW2, SYT6, RASA3 148 106 16659 4.2475777664456915 0.9999999999848417 0.7892388174078093 61.60391178479961 UP_SEQ_FEATURE domain:C2 1 3 1.675977653631285 0.09049063002224236 MCTP2, SYT6, RASA3 173 56 19113 5.918559042113954 1.0 0.9885698307941923 75.80749677934335 UP_SEQ_FEATURE domain:C2 2 3 1.675977653631285 0.09049063002224236 MCTP2, SYT6, RASA3 173 56 19113 5.918559042113954 1.0 0.9885698307941923 75.80749677934335 INTERPRO IPR000008:C2 calcium-dependent membrane targeting 4 2.2346368715083798 0.12088223655836254 MCTP2, HECW2, SYT6, RASA3 148 137 16659 3.2864470309725786 1.0 0.8763949229779072 82.91988663933793 SMART SM00239:C2 4 2.2346368715083798 0.1473684415756563 MCTP2, HECW2, SYT6, RASA3 89 137 9079 2.978430246862954 0.999999573372262 0.8401339899017877 82.47814152520597 Annotation Cluster 23 Enrichment Score: 0.9681556603129344 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045087~innate immune response 5 2.793296089385475 0.03261192147687706 TNFAIP8L2, CYBA, IL1RAP, CLEC7A, TLR9 119 138 13528 4.11886493727926 0.9999999999999984 0.644007410842321 40.88536382169868 GOTERM_BP_FAT GO:0009611~response to wounding 10 5.58659217877095 0.042108188557456745 CYBA, ACVRL1, STAB1, IL1RAP, CRP, F2RL1, CLEC7A, SCNN1B, PLG, TLR9 119 530 13528 2.1449183446963693 1.0 0.7072606153852922 49.44471609050694 SP_PIR_KEYWORDS inflammatory response 3 1.675977653631285 0.15111831163438083 STAB1, CLEC7A, TLR9 173 77 19235 4.331881990841528 1.0 0.7809879777047541 87.9499194150189 GOTERM_BP_FAT GO:0006954~inflammatory response 6 3.35195530726257 0.15470798920688622 CYBA, STAB1, IL1RAP, CRP, CLEC7A, TLR9 119 325 13528 2.0987201034259857 1.0 0.9031753667224773 93.03904097114484 GOTERM_BP_FAT GO:0006952~defense response 7 3.910614525139665 0.4494164006624243 TNFAIP8L2, CYBA, STAB1, IL1RAP, CRP, CLEC7A, TLR9 119 615 13528 1.2939263510282162 1.0 0.9827995995770809 99.99222553193027 Annotation Cluster 24 Enrichment Score: 0.8678025766341256 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 5 3 1.675977653631285 0.05252194125355776 CRB2, STAB1, DLK1 173 41 19113 8.083885520936134 0.9999999999999997 0.9607219703090508 55.389998161818035 UP_SEQ_FEATURE domain:EGF-like 6 3 1.675977653631285 0.057173779343261164 CRB2, STAB1, DLK1 173 43 19113 7.707890845543756 1.0 0.9607589280105354 58.55699584771643 INTERPRO IPR000742:EGF-like, type 3 5 2.793296089385475 0.09296230771335277 EGFL6, CRB2, STAB1, DLK1, MUC17 148 194 16659 2.9010518250208976 0.9999999999999992 0.8555993532859757 73.77323875333856 UP_SEQ_FEATURE domain:EGF-like 1 4 2.2346368715083798 0.09416171720695779 EGFL6, CRB2, STAB1, DLK1 173 120 19113 3.682658959537572 1.0 0.9871106942895809 77.22804647238671 INTERPRO IPR006210:EGF-like 5 2.793296089385475 0.10246498586924158 EGFL6, CRB2, STAB1, DLK1, MUC17 148 201 16659 2.800020169423155 1.0 0.8688221476289731 77.30115395911439 INTERPRO IPR013111:EGF, extracellular 3 1.675977653631285 0.10670271007541678 EGFL6, STAB1, DLK1 148 63 16659 5.36003861003861 1.0 0.8665621937856518 78.72791876934998 INTERPRO IPR013032:EGF-like region, conserved site 6 3.35195530726257 0.11786713666165972 LAMA1, EGFL6, CRB2, STAB1, DLK1, MUC17 148 293 16659 2.3049995387879347 1.0 0.8814018184834098 82.09858903466117 SMART SM00181:EGF 5 2.793296089385475 0.13065109504557215 EGFL6, CRB2, STAB1, DLK1, MUC17 89 201 9079 2.5375929342053776 0.9999974540008746 0.8412049746759789 78.33762527170559 UP_SEQ_FEATURE domain:EGF-like 3 3 1.675977653631285 0.14640358028736572 EGFL6, STAB1, DLK1 173 75 19113 4.419190751445086 1.0 0.9985406175327195 90.63701735494601 INTERPRO IPR001881:EGF-like calcium-binding 3 1.675977653631285 0.20781147594627353 EGFL6, CRB2, DLK1 148 96 16659 3.5175253378378377 1.0 0.9591832780663494 95.9052605442428 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site 3 1.675977653631285 0.21103936343934007 EGFL6, CRB2, DLK1 148 97 16659 3.481262190025077 1.0 0.9564645767922444 96.12828795360598 SMART SM00179:EGF_CA 3 1.675977653631285 0.23840757550219252 EGFL6, CRB2, DLK1 89 96 9079 3.1878511235955056 0.9999999999868635 0.9382065715194118 94.89683279368968 INTERPRO IPR006209:EGF 3 1.675977653631285 0.30887586469673833 CRB2, STAB1, DLK1 148 127 16659 2.658916790806555 1.0 0.9894103948282247 99.37022894746477 SP_PIR_KEYWORDS egf-like domain 4 2.2346368715083798 0.33892183584146385 EGFL6, CRB2, STAB1, DLK1 173 230 19235 1.9336516712741894 1.0 0.9373829737932503 99.52314621520833 Annotation Cluster 25 Enrichment Score: 0.7976784849704871 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006909~phagocytosis 3 1.675977653631285 0.06563675600772634 CRP, CLEC7A, ELMO2 119 48 13528 7.105042016806722 1.0 0.773478016763826 65.91857141820951 GOTERM_BP_FAT GO:0010324~membrane invagination 5 2.793296089385475 0.126187601798909 RAMP3, STAB1, CRP, CLEC7A, ELMO2 119 220 13528 2.583651642475172 1.0 0.8815578341220273 88.21941100864635 GOTERM_BP_FAT GO:0006897~endocytosis 5 2.793296089385475 0.126187601798909 RAMP3, STAB1, CRP, CLEC7A, ELMO2 119 220 13528 2.583651642475172 1.0 0.8815578341220273 88.21941100864635 GOTERM_BP_FAT GO:0006954~inflammatory response 6 3.35195530726257 0.15470798920688622 CYBA, STAB1, IL1RAP, CRP, CLEC7A, TLR9 119 325 13528 2.0987201034259857 1.0 0.9031753667224773 93.03904097114484 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 8 4.4692737430167595 0.2375276064036838 RAMP3, LAT2, STAB1, CRP, SYT6, CLEC7A, PEX5L, ELMO2 119 576 13528 1.5788982259570494 1.0 0.9484791554354765 98.64285546859537 GOTERM_BP_FAT GO:0016044~membrane organization 5 2.793296089385475 0.42611004717430945 RAMP3, STAB1, CRP, CLEC7A, ELMO2 119 381 13528 1.4918723394869762 1.0 0.9788730579228471 99.98499792820924 Annotation Cluster 26 Enrichment Score: 0.7517667626098602 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007600~sensory perception 13 7.262569832402235 0.04996148942849249 OR10A2, TBX1, NTSR2, GJB2, GJA3, OR12D2, TAS2R13, LRAT, PNOC, CRB2, MYO15A, SCNN1B, MYC 119 810 13528 1.8245046166614796 1.0 0.7321145659006402 55.63098158726636 GOTERM_BP_FAT GO:0050890~cognition 13 7.262569832402235 0.09838360869513055 OR10A2, TBX1, NTSR2, GJB2, GJA3, OR12D2, TAS2R13, LRAT, PNOC, CRB2, MYO15A, SCNN1B, MYC 119 909 13528 1.6257961930646847 1.0 0.8556833212835806 80.64218484955914 GOTERM_BP_FAT GO:0050877~neurological system process 14 7.82122905027933 0.25567877517913173 OR10A2, TBX1, VIPR1, NTSR2, GJB2, GJA3, OR12D2, TAS2R13, LRAT, PNOC, CRB2, MYO15A, SCNN1B, MYC 119 1210 13528 1.3153135634419058 1.0 0.9519496067181933 99.0737664922914 SP_PIR_KEYWORDS sensory transduction 5 2.793296089385475 0.7828528683363073 TAS2R13, OR12D2, LRAT, OR10A2, SCNN1B 173 595 19235 0.9343274882207218 1.0 0.9984305417084023 99.99999972865889 Annotation Cluster 27 Enrichment Score: 0.6752228865503558 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction 7 3.910614525139665 0.03521478179759291 CCL1, IL22RA1, ACVRL1, PRLR, IL1RAP, IL26, FASLG 49 262 5085 2.7726281352235547 0.9295522016798363 0.9295522016798363 31.28676924250582 SP_PIR_KEYWORDS cytokine 3 1.675977653631285 0.4830329027734809 CCL1, IL26, FASLG 173 181 19235 1.8428448248331362 1.0 0.9730500370140509 99.9800892916785 GOTERM_MF_FAT GO:0005125~cytokine activity 3 1.675977653631285 0.5541529174764996 CCL1, IL26, FASLG 124 195 12983 1.6107940446650124 1.0 0.999558083266159 99.99801431759914 Annotation Cluster 28 Enrichment Score: 0.5876367678287486 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS motor protein 5 2.793296089385475 0.03088033426405286 DNAH11, KIF12, DNAH9, MYO7B, MYO15A 173 132 19235 4.211551935540375 0.9994788593234917 0.37653843440944645 33.31155732174174 GOTERM_MF_FAT GO:0003774~motor activity 5 2.793296089385475 0.04595946679558988 DNAH11, KIF12, DNAH9, MYO7B, MYO15A 124 142 12983 3.6866765106769646 0.99999944095226 0.7298616373060219 46.773654522386266 GOTERM_BP_FAT GO:0007018~microtubule-based movement 4 2.2346368715083798 0.07609756591767014 DNAH11, KIF12, DNAH9, TUBB1 119 113 13528 4.0240945935896475 1.0 0.8035405842844121 71.4904026862679 SP_PIR_KEYWORDS microtubule 5 2.793296089385475 0.1524958159913249 DNAH11, KIF12, DNAH9, FAM110C, TUBB1 173 231 19235 2.4066011060230714 1.0 0.75928306470618 88.20005153933722 GOTERM_MF_FAT GO:0003777~microtubule motor activity 3 1.675977653631285 0.16536584068651444 DNAH11, KIF12, DNAH9 124 77 12983 4.0792836196062 1.0 0.9613694586454986 91.1328500656871 GOTERM_CC_FAT GO:0005875~microtubule associated complex 3 1.675977653631285 0.26921638211585447 DNAH11, KIF12, DNAH9 128 102 12782 2.9370404411764706 1.0 0.9714061192184623 98.06269182072941 GOTERM_CC_FAT GO:0005874~microtubule 5 2.793296089385475 0.2898435491241834 DNAH11, KIF12, DNAH9, FAM110C, TUBB1 128 274 12782 1.8222513686131387 1.0 0.9581547160189257 98.64843636812793 GOTERM_BP_FAT GO:0007017~microtubule-based process 4 2.2346368715083798 0.3798575390537595 DNAH11, KIF12, DNAH9, TUBB1 119 253 13528 1.7973228817218587 1.0 0.974410083034135 99.94872727953711 GOTERM_CC_FAT GO:0044430~cytoskeletal part 10 5.58659217877095 0.6110350722371082 DNAH11, KIF12, DNAH9, KRT80, MYO7B, FAM110C, MYO15A, AMOT, TUBB1, MYC 128 952 12782 1.0489430147058825 1.0 0.9959284129137398 99.99930291145081 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 6 3.35195530726257 0.6415737209443262 DNAH11, KIF12, DNAH9, FAM110C, TUBB1, MYC 128 549 12782 1.0913592896174864 1.0 0.9970150817061728 99.9997506804312 GOTERM_CC_FAT GO:0005856~cytoskeleton 13 7.262569832402235 0.7309453618786859 DNAH11, KIF12, DNAH9, MYO7B, FAM110C, FRMPD2, KLHL4, ELMO2, KRT80, MYO15A, AMOT, TUBB1, MYC 128 1381 12782 0.9400230811006517 1.0 0.9987635218005305 99.99999323181444 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 16 8.938547486033519 0.9959866725482924 DNAH11, KIF12, DNAH9, HMGB4, MYO7B, FAM110C, MAEL, FRMPD2, KLHL4, ELMO2, KRT80, MYO15A, AMOT, TUBB1, HPGD, MYC 128 2596 12782 0.6154661016949152 1.0 0.9999999981383004 100.0 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 16 8.938547486033519 0.9959866725482924 DNAH11, KIF12, DNAH9, HMGB4, MYO7B, FAM110C, MAEL, FRMPD2, KLHL4, ELMO2, KRT80, MYO15A, AMOT, TUBB1, HPGD, MYC 128 2596 12782 0.6154661016949152 1.0 0.9999999981383004 100.0 Annotation Cluster 29 Enrichment Score: 0.5730130734144707 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006887~exocytosis 3 1.675977653631285 0.2653748514763637 LAT2, SYT6, PEX5L 119 115 13528 2.9655827548410674 1.0 0.9566700236124434 99.24763149063973 GOTERM_BP_FAT GO:0046903~secretion 5 2.793296089385475 0.266310954091332 LAT2, SYT6, SCNN1B, PCSK6, PEX5L 119 300 13528 1.8946778711484593 1.0 0.9531577020147752 99.26268915006885 GOTERM_BP_FAT GO:0032940~secretion by cell 4 2.2346368715083798 0.2702165750872711 LAT2, SYT6, PCSK6, PEX5L 119 207 13528 2.1967279665489383 1.0 0.9542275595585463 99.32251861154798 Annotation Cluster 30 Enrichment Score: 0.545042444833051 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019725~cellular homeostasis 8 4.4692737430167595 0.11293651651756634 CCL1, TXNDC3, MFI2, F2RL1, RYR2, NTSR2, MYC, PLG 119 466 13528 1.9515995239297435 1.0 0.871681121781472 85.04435068059497 GOTERM_BP_FAT GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 5 2.793296089385475 0.13692732303252858 CCL1, MFI2, F2RL1, RYR2, MYC 119 227 13528 2.50397956539444 1.0 0.8920589394384161 90.31698245043273 GOTERM_BP_FAT GO:0055066~di-, tri-valent inorganic cation homeostasis 5 2.793296089385475 0.15616217271997684 CCL1, MFI2, F2RL1, RYR2, MYC 119 239 13528 2.378256742027355 1.0 0.9024434227561106 93.22650402628824 GOTERM_BP_FAT GO:0030003~cellular cation homeostasis 5 2.793296089385475 0.18152952231915243 CCL1, MFI2, F2RL1, RYR2, MYC 119 254 13528 2.2378085092304643 1.0 0.9213153229201947 95.82520407996033 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 6 3.35195530726257 0.22805210306285933 CCL1, MFI2, F2RL1, RYR2, NTSR2, MYC 119 374 13528 1.8237541005707096 1.0 0.946282615631159 98.34928585599148 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 6 3.35195530726257 0.23768497216747086 CCL1, MFI2, F2RL1, RYR2, NTSR2, MYC 119 380 13528 1.7949579831932774 1.0 0.9469639686684692 98.64728973242688 GOTERM_BP_FAT GO:0055080~cation homeostasis 5 2.793296089385475 0.23961948282772116 CCL1, MFI2, F2RL1, RYR2, MYC 119 286 13528 1.9874243403655172 1.0 0.9467842626156531 98.70070300653711 GOTERM_BP_FAT GO:0050801~ion homeostasis 6 3.35195530726257 0.28568637838638455 CCL1, MFI2, F2RL1, RYR2, NTSR2, MYC 119 409 13528 1.6676871237492552 1.0 0.9544058497827655 99.51764960731964 GOTERM_BP_FAT GO:0048878~chemical homeostasis 6 3.35195530726257 0.46350132768745195 CCL1, MFI2, F2RL1, RYR2, NTSR2, MYC 119 512 13528 1.3321953781512603 1.0 0.984340317710105 99.99484504205259 GOTERM_BP_FAT GO:0006874~cellular calcium ion homeostasis 3 1.675977653631285 0.47600056995681983 CCL1, F2RL1, RYR2 119 183 13528 1.8636175781788125 1.0 0.9858595889354906 99.99645267506038 GOTERM_BP_FAT GO:0042592~homeostatic process 8 4.4692737430167595 0.4842571007218661 CCL1, TXNDC3, MFI2, F2RL1, RYR2, NTSR2, MYC, PLG 119 751 13528 1.2109791986035425 1.0 0.9865415163870682 99.99724235719049 GOTERM_BP_FAT GO:0055074~calcium ion homeostasis 3 1.675977653631285 0.49015120654179617 CCL1, F2RL1, RYR2 119 188 13528 1.8140532808868228 1.0 0.9864485409904437 99.9977017860069 GOTERM_BP_FAT GO:0006875~cellular metal ion homeostasis 3 1.675977653631285 0.5122937545340955 CCL1, F2RL1, RYR2 119 196 13528 1.7400102898302179 1.0 0.9882824762264999 99.9988632862079 GOTERM_BP_FAT GO:0055065~metal ion homeostasis 3 1.675977653631285 0.5364473487790542 CCL1, F2RL1, RYR2 119 205 13528 1.6636195941791352 1.0 0.9898991120437166 99.99949196368982 Annotation Cluster 31 Enrichment Score: 0.5449969797431541 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014706~striated muscle tissue development 3 1.675977653631285 0.27832013464433225 MEOX2, ZFPM2, SIX4 119 119 13528 2.8658993008968294 1.0 0.9551615754133258 99.43244430049124 GOTERM_BP_FAT GO:0007517~muscle organ development 4 2.2346368715083798 0.27968669810439273 MEOX2, TBX1, ZFPM2, SIX4 119 211 13528 2.1550838344816596 1.0 0.9533906500413946 99.44924668105422 GOTERM_BP_FAT GO:0060537~muscle tissue development 3 1.675977653631285 0.2977094518581469 MEOX2, ZFPM2, SIX4 119 125 13528 2.7283361344537815 1.0 0.9563663539477149 99.63146773574897 Annotation Cluster 32 Enrichment Score: 0.531389102628364 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000267~cell fraction 14 7.82122905027933 0.2786208196668737 NRP2, GCNT3, IL26, DLK1, CYP2E1, PEX5L, PLG, LRAT, MCTP2, GPR34, SLC17A2, RYR2, PCSK6, SCNN1B 128 1083 12782 1.2908875807940905 1.0 0.9699997404803223 98.35387017144032 GOTERM_CC_FAT GO:0005624~membrane fraction 11 6.145251396648044 0.2834282189880589 NRP2, GCNT3, MCTP2, LRAT, GPR34, SLC17A2, RYR2, CYP2E1, SCNN1B, PEX5L, PLG 128 809 12782 1.3577912546353523 1.0 0.96073990147432 98.48661762647009 GOTERM_CC_FAT GO:0005626~insoluble fraction 11 6.145251396648044 0.3223858998172838 NRP2, GCNT3, MCTP2, LRAT, GPR34, SLC17A2, RYR2, CYP2E1, SCNN1B, PEX5L, PLG 128 839 12782 1.3092409117997617 1.0 0.9634109871231062 99.25067235478487 Annotation Cluster 33 Enrichment Score: 0.5289092968377996 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Signal-anchor 8 4.4692737430167595 0.0844239887435918 LAT2, GCNT3, B3GNT7, HS6ST2, FASLG, CLEC7A, CLEC4D, MAN1C1 173 421 19235 2.112778548185575 0.999999999413387 0.6194781303027728 67.99300368119634 GOTERM_BP_FAT GO:0009100~glycoprotein metabolic process 5 2.793296089385475 0.10035462240026594 GCNT3, HPSE, B3GNT7, PCSK6, MAN1C1 119 202 13528 2.813878026458108 1.0 0.8564902976699791 81.30236314178578 GOTERM_BP_FAT GO:0043413~biopolymer glycosylation 3 1.675977653631285 0.30737828193652994 GCNT3, B3GNT7, MAN1C1 119 128 13528 2.6643907563025206 1.0 0.9592222088691553 99.70418845619322 GOTERM_BP_FAT GO:0070085~glycosylation 3 1.675977653631285 0.30737828193652994 GCNT3, B3GNT7, MAN1C1 119 128 13528 2.6643907563025206 1.0 0.9592222088691553 99.70418845619322 GOTERM_BP_FAT GO:0006486~protein amino acid glycosylation 3 1.675977653631285 0.30737828193652994 GCNT3, B3GNT7, MAN1C1 119 128 13528 2.6643907563025206 1.0 0.9592222088691553 99.70418845619322 GOTERM_BP_FAT GO:0009101~glycoprotein biosynthetic process 3 1.675977653631285 0.401941993277872 GCNT3, B3GNT7, MAN1C1 119 158 13528 2.1584937772577386 1.0 0.9770565875699526 99.9711467794108 UP_SEQ_FEATURE topological domain:Lumenal 4 2.2346368715083798 0.7660050525317718 GCNT3, B3GNT7, HS6ST2, MAN1C1 173 444 19113 0.995313232307452 1.0 0.9999999991098067 99.99999996350888 SP_PIR_KEYWORDS golgi apparatus 5 2.793296089385475 0.775010924477566 GCNT3, GIMAP8, B3GNT7, MAN1C1, CD1E 173 588 19235 0.9454504345090637 1.0 0.9985502631425933 99.99999957094128 Annotation Cluster 34 Enrichment Score: 0.5146435453045556 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS receptor 23 12.849162011173185 0.025581356372890808 FGFR2, RAMP3, NRP2, GPR174, ACVRL1, IL22RA1, OR10A2, F2RL1, KIR2DS2, PTPN22, VIPR1, NTSR2, TLR9, TAS2R13, OR12D2, GPR34, PRLR, STAB1, GPR26, IL1RAP, LRP11, RYR2, CLEC7A 173 1583 19235 1.615448095552821 0.9980605172257705 0.34055426803549205 28.445332651137377 GOTERM_BP_FAT GO:0007166~cell surface receptor linked signal transduction 22 12.290502793296088 0.12499811547217075 FGFR2, RAMP3, GPR174, ACVRL1, OR10A2, WNT3A, F2RL1, PTPN22, VIPR1, NTSR2, NKX6-1, LAMA1, TAS2R13, DOK2, OR12D2, LAT2, GPR34, PRLR, PNOC, GPR26, CLEC7A, HPGD 119 1856 13528 1.3475079687047233 1.0 0.8829101159659447 87.96256090930967 SP_PIR_KEYWORDS g-protein coupled receptor 9 5.027932960893855 0.44651719709027327 GPR174, TAS2R13, OR12D2, GPR34, OR10A2, GPR26, F2RL1, VIPR1, NTSR2 173 816 19235 1.2263048282896976 1.0 0.966433424149373 99.95192350099309 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 7 3.910614525139665 0.5037531241573875 GPR174, OR12D2, GPR34, OR10A2, GPR26, F2RL1, NTSR2 62 686 7396 1.21724818959842 1.0 0.9999999998711222 99.92083021572921 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 11 6.145251396648044 0.5210665668593759 RAMP3, GPR174, TAS2R13, OR12D2, GPR34, PNOC, OR10A2, GPR26, F2RL1, VIPR1, NTSR2 119 1123 13528 1.113523949205684 1.0 0.9892384851357328 99.99914756535239 SP_PIR_KEYWORDS transducer 9 5.027932960893855 0.5241921253779858 GPR174, TAS2R13, OR12D2, GPR34, OR10A2, GPR26, F2RL1, VIPR1, NTSR2 173 874 19235 1.1449253316755068 1.0 0.9812730457709251 99.99318121950333 INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 7 3.910614525139665 0.6227674095874618 GPR174, OR12D2, GPR34, OR10A2, GPR26, F2RL1, NTSR2 148 726 16659 1.0852970739334378 1.0 0.9999519809128409 99.99984428589282 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 7 3.910614525139665 0.6241070430839089 GPR174, OR12D2, GPR34, OR10A2, GPR26, F2RL1, NTSR2 148 727 16659 1.0838042306405444 1.0 0.9999388983128764 99.99985170214102 Annotation Cluster 35 Enrichment Score: 0.5038658625323726 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 4 2.2346368715083798 0.10665837600522375 TXNDC3, ATP11B, ATP11A, ENTPD3 119 131 13528 3.471165565462826 1.0 0.8598660319984284 83.2749270538658 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 3 1.675977653631285 0.21059324012535563 TXNDC3, ATP11B, ATP11A 119 98 13528 3.4800205796604358 1.0 0.9407911266060045 97.64672741863875 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 3 1.675977653631285 0.21379007914157 TXNDC3, ATP11B, ATP11A 119 99 13528 3.4448688566335623 1.0 0.9416993303525147 97.7933671942149 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 3 1.675977653631285 0.21379007914157 TXNDC3, ATP11B, ATP11A 119 99 13528 3.4448688566335623 1.0 0.9416993303525147 97.7933671942149 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 3 1.675977653631285 0.22340766037981608 TXNDC3, ATP11B, ATP11A 119 102 13528 3.343549184379634 1.0 0.9443120522785766 98.18458139906498 GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 3 1.675977653631285 0.27184816090524355 TXNDC3, ATP11B, ATP11A 119 117 13528 2.9148890325360917 1.0 0.9538881144891401 99.34613921124344 GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 3 1.675977653631285 0.27184816090524355 TXNDC3, ATP11B, ATP11A 119 117 13528 2.9148890325360917 1.0 0.9538881144891401 99.34613921124344 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 3 1.675977653631285 0.27508443448832415 TXNDC3, ATP11B, ATP11A 119 118 13528 2.8901865831078197 1.0 0.9545310734889487 99.39072581732837 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 3 1.675977653631285 0.28802147139129275 TXNDC3, ATP11B, ATP11A 119 122 13528 2.7954263672682185 1.0 0.9545179071543497 99.54205237092475 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 3 1.675977653631285 0.2944819731137895 TXNDC3, ATP11B, ATP11A 119 124 13528 2.7503388452155058 1.0 0.9557621226432791 99.60367809643516 GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 3 1.675977653631285 0.33940109507332156 TXNDC3, ATP11B, ATP11A 119 138 13528 2.4713189623675555 1.0 0.9678466160025343 99.86034469254305 GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 3 1.675977653631285 0.36783974585230794 TXNDC3, ATP11B, ATP11A 119 147 13528 2.3200137197736237 1.0 0.9733925853178744 99.93048927389263 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 3 1.675977653631285 0.3709720252276007 TXNDC3, ATP11B, ATP11A 119 148 13528 2.304337951396775 1.0 0.9722121445407571 99.93575367187579 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 3 1.675977653631285 0.48451922097918454 TXNDC3, ATP11B, ATP11A 119 186 13528 1.8335592301436705 1.0 0.9862172458502607 99.99726449535272 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 3 1.675977653631285 0.48451922097918454 TXNDC3, ATP11B, ATP11A 119 186 13528 1.8335592301436705 1.0 0.9862172458502607 99.99726449535272 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 3 1.675977653631285 0.5040633482741623 TXNDC3, ATP11B, ATP11A 119 193 13528 1.7670570819001177 1.0 0.9876734281036174 99.9985178716707 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 3 1.675977653631285 0.5040633482741623 TXNDC3, ATP11B, ATP11A 119 193 13528 1.7670570819001177 1.0 0.9876734281036174 99.9985178716707 GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 3 1.675977653631285 0.7798197240970907 TXNDC3, ATP11B, ATP11A 119 325 13528 1.0493600517129928 1.0 0.9994553507090388 99.9999999962021 Annotation Cluster 36 Enrichment Score: 0.4976796059602435 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Iron (heme axial ligand) 3 1.675977653631285 0.22058749818341644 FRRS1, CYBA, CYP2E1 173 98 19113 3.3820337383508314 1.0 0.9997318837531558 97.59760790419705 SP_PIR_KEYWORDS iron 5 2.793296089385475 0.25167538598212547 FRRS1, CYBA, CH25H, MFI2, CYP2E1 173 285 19235 1.9506135280397525 1.0 0.8796418021991645 97.63545943768946 SP_PIR_KEYWORDS heme 3 1.675977653631285 0.29458661389693847 FRRS1, CYBA, CYP2E1 173 121 19235 2.7566521759900633 1.0 0.9095462456632172 98.89719504159592 GOTERM_MF_FAT GO:0005506~iron ion binding 5 2.793296089385475 0.3340481809518445 FRRS1, CYBA, CH25H, MFI2, CYP2E1 124 308 12983 1.69970150816925 1.0 0.9973250879304836 99.56993020497733 SP_PIR_KEYWORDS oxidoreductase 7 3.910614525139665 0.3885497231603498 FRRS1, CYBA, CH25H, DAO, ADH1A, CYP2E1, HPGD 173 562 19235 1.3848661880566926 1.0 0.9483790604996362 99.82596345476212 GOTERM_BP_FAT GO:0055114~oxidation reduction 7 3.910614525139665 0.4864430493590095 FRRS1, CYBA, CH25H, DAO, ADH1A, CYP2E1, HPGD 119 639 13528 1.2453281782196446 1.0 0.9861792430779979 99.99742195456734 Annotation Cluster 37 Enrichment Score: 0.4699722925228484 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007507~heart development 5 2.793296089385475 0.11874710432068318 NRP2, WNT3A, GJA1, TBX1, ZFPM2 119 215 13528 2.6437365643931994 1.0 0.8812019293744212 86.52428228370196 GOTERM_BP_FAT GO:0000902~cell morphogenesis 6 3.35195530726257 0.19992020775210592 NRP2, LAMA1, HOXA2, WNT3A, MAEL, GJA1 119 356 13528 1.915966386554622 1.0 0.9347566701292653 97.08829248933375 GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 6 3.35195530726257 0.2655651896070943 NRP2, LAMA1, HOXA2, WNT3A, MAEL, GJA1 119 397 13528 1.718095802552759 1.0 0.954065882065645 99.2507163116278 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 4 2.2346368715083798 0.2844343010831405 NRP2, HOXA2, WNT3A, GJA1 119 213 13528 2.1348483055193905 1.0 0.9549316999812566 99.5040682545271 GOTERM_BP_FAT GO:0030182~neuron differentiation 6 3.35195530726257 0.3353639462383845 NRP2, HOXA2, LMX1B, WNT3A, GJA1, NKX6-1 119 438 13528 1.55726948313572 1.0 0.9680072780562029 99.84618051328565 GOTERM_BP_FAT GO:0048666~neuron development 5 2.793296089385475 0.3429259813915889 NRP2, HOXA2, LMX1B, WNT3A, GJA1 119 339 13528 1.6767060806623535 1.0 0.9683728569659353 99.87170292551295 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 4 2.2346368715083798 0.3608350918132588 NRP2, HOXA2, WNT3A, GJA1 119 245 13528 1.856010975818899 1.0 0.971755695120323 99.91721890045898 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 4 2.2346368715083798 0.3869631692406659 NRP2, HOXA2, WNT3A, GJA1 119 256 13528 1.7762605042016804 1.0 0.9752458245317015 99.95728975456454 GOTERM_BP_FAT GO:0031175~neuron projection development 4 2.2346368715083798 0.3869631692406659 NRP2, HOXA2, WNT3A, GJA1 119 256 13528 1.7762605042016804 1.0 0.9752458245317015 99.95728975456454 GOTERM_BP_FAT GO:0030030~cell projection organization 5 2.793296089385475 0.40050623204476643 NRP2, HOXA2, DNAH9, WNT3A, GJA1 119 368 13528 1.5445743514797226 1.0 0.9772717613361306 99.9700287091494 GOTERM_BP_FAT GO:0007409~axonogenesis 3 1.675977653631285 0.5040633482741623 NRP2, HOXA2, WNT3A 119 193 13528 1.7670570819001177 1.0 0.9876734281036174 99.9985178716707 GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 3 1.675977653631285 0.5469191185611824 NRP2, HOXA2, WNT3A 119 209 13528 1.6317799847211614 1.0 0.9904439581718368 99.99964636343357 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 3 1.675977653631285 0.6314588654588309 NRP2, HOXA2, WNT3A 119 244 13528 1.3977131836341092 1.0 0.9954870458201149 99.99998661872736 Annotation Cluster 38 Enrichment Score: 0.4389375222865829 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006694~steroid biosynthetic process 3 1.675977653631285 0.16962071678231944 PRLR, CH25H, SCP2 119 85 13528 4.012259021255561 1.0 0.9136811311456206 94.75067608408968 GOTERM_BP_FAT GO:0008202~steroid metabolic process 3 1.675977653631285 0.5284866540957099 PRLR, CH25H, SCP2 119 202 13528 1.6883268158748648 1.0 0.9896743808382299 99.99933450689028 GOTERM_BP_FAT GO:0008610~lipid biosynthetic process 4 2.2346368715083798 0.5378665230283448 PRLR, CH25H, FABP3, SCP2 119 323 13528 1.407810182896688 1.0 0.9898145039419065 99.99951607151219 Annotation Cluster 39 Enrichment Score: 0.4341100160067039 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060284~regulation of cell development 4 2.2346368715083798 0.2654957972421099 HOXA2, LRRC4C, BOC, NKX6-1 119 205 13528 2.218159458905513 1.0 0.9553899613952748 99.24959304083316 GOTERM_BP_FAT GO:0045664~regulation of neuron differentiation 3 1.675977653631285 0.3234356653274776 HOXA2, LRRC4C, NKX6-1 119 133 13528 2.5642256902761105 1.0 0.9657942765301504 99.79606258207373 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 3 1.675977653631285 0.42620292431319007 HOXA2, LRRC4C, NKX6-1 119 166 13528 2.0544699807633897 1.0 0.9783431949027017 99.98503637715255 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 3 1.675977653631285 0.5013002857051447 HOXA2, LRRC4C, NKX6-1 119 192 13528 1.7762605042016806 1.0 0.9875735427586042 99.99838138588657 Annotation Cluster 40 Enrichment Score: 0.41687989127124453 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000323~lytic vacuole 4 2.2346368715083798 0.3497324096235102 RAMP3, HPSE, GJA1, CD1E 128 211 12782 1.893068720379147 1.0 0.9658420394130934 99.55361656063914 GOTERM_CC_FAT GO:0005764~lysosome 4 2.2346368715083798 0.3497324096235102 RAMP3, HPSE, GJA1, CD1E 128 211 12782 1.893068720379147 1.0 0.9658420394130934 99.55361656063914 GOTERM_CC_FAT GO:0005773~vacuole 4 2.2346368715083798 0.4590802039361293 RAMP3, HPSE, GJA1, CD1E 128 252 12782 1.5850694444444444 1.0 0.9846784199609672 99.95591887058316 Annotation Cluster 41 Enrichment Score: 0.4003622978532961 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006461~protein complex assembly 7 3.910614525139665 0.2784931303412086 CYBA, PRLR, IL1RAP, MUC20, GJA1, TUBB1, MYC 119 505 13528 1.5757716948165406 1.0 0.953970255350105 99.43459758317306 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 7 3.910614525139665 0.2784931303412086 CYBA, PRLR, IL1RAP, MUC20, GJA1, TUBB1, MYC 119 505 13528 1.5757716948165406 1.0 0.953970255350105 99.43459758317306 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 8 4.4692737430167595 0.3606688439221202 CYBA, PRLR, IL1RAP, MUC20, GJA1, NAP1L2, TUBB1, MYC 119 665 13528 1.3675870348139254 1.0 0.9724744575547765 99.9168768512543 GOTERM_BP_FAT GO:0043623~cellular protein complex assembly 3 1.675977653631285 0.4141336911637531 CYBA, PRLR, TUBB1 119 162 13528 2.1051976346093997 1.0 0.9774175215640359 99.9791852169341 GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 8 4.4692737430167595 0.4255866506647033 CYBA, PRLR, IL1RAP, MUC20, GJA1, NAP1L2, TUBB1, MYC 119 710 13528 1.2809089833116345 1.0 0.9792885932072074 99.98477951807932 GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 4 2.2346368715083798 0.5272887874421526 CYBA, PRLR, NAP1L2, TUBB1 119 318 13528 1.4299455631309128 1.0 0.9897944400168887 99.99930718902242 GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 4 2.2346368715083798 0.6061068845567679 CYBA, PRLR, NAP1L2, TUBB1 119 357 13528 1.273733022620813 1.0 0.9946661151661466 99.99996157658721 Annotation Cluster 42 Enrichment Score: 0.36758794493701863 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Fibronectin type-III 2 3 1.675977653631285 0.32693856406365424 IL22RA1, PRLR, BOC 173 130 19113 2.5495331258337033 1.0 0.9999883609455561 99.73246096167374 UP_SEQ_FEATURE domain:Fibronectin type-III 1 3 1.675977653631285 0.33023129166191983 IL22RA1, PRLR, BOC 173 131 19113 2.5300710409036755 1.0 0.9999836719820787 99.7513888025189 INTERPRO IPR008957:Fibronectin, type III-like fold 3 1.675977653631285 0.48457661658295675 IL22RA1, PRLR, BOC 148 184 16659 1.8352306110458285 1.0 0.9993850625599928 99.98873473917979 INTERPRO IPR003961:Fibronectin, type III 3 1.675977653631285 0.5017922408498141 IL22RA1, PRLR, BOC 148 190 16659 1.7772759601706971 1.0 0.9994672399730722 99.99293088596944 SMART SM00060:FN3 3 1.675977653631285 0.5532093432533693 IL22RA1, PRLR, BOC 89 190 9079 1.61070372560615 1.0 0.9988153289333049 99.98495310362004 Annotation Cluster 43 Enrichment Score: 0.34402311054465473 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006935~chemotaxis 3 1.675977653631285 0.40805274987109824 CCL1, NRP2, AMOT 119 160 13528 2.131512605042017 1.0 0.9769332963675351 99.97548257825454 GOTERM_BP_FAT GO:0042330~taxis 3 1.675977653631285 0.40805274987109824 CCL1, NRP2, AMOT 119 160 13528 2.131512605042017 1.0 0.9769332963675351 99.97548257825454 GOTERM_BP_FAT GO:0007626~locomotory behavior 4 2.2346368715083798 0.4291474139080777 CCL1, NRP2, MYO15A, AMOT 119 274 13528 1.6595718579402565 1.0 0.9785524530473926 99.986208538146 GOTERM_BP_FAT GO:0007610~behavior 5 2.793296089385475 0.5886653053942661 CCL1, NRP2, MYO15A, AMOT, TBX1 119 469 13528 1.2119474655533857 1.0 0.9937392446640538 99.99992362614988 Annotation Cluster 44 Enrichment Score: 0.33924719542543924 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS lipoprotein 8 4.4692737430167595 0.35120113066037284 LAT2, APOD, HFE2, WNT3A, LRP11, MFI2, NTSR2, PLG 173 642 19235 1.3854825058973943 1.0 0.9356746175333623 99.62570523333606 UP_SEQ_FEATURE lipid moiety-binding region:S-palmitoyl cysteine 3 1.675977653631285 0.48607547161552034 LAT2, WNT3A, NTSR2 173 181 19113 1.8311563887203397 1.0 0.9999997366896837 99.99527359569889 SP_PIR_KEYWORDS palmitate 3 1.675977653631285 0.5623397740992624 LAT2, WNT3A, NTSR2 173 213 19235 1.5659855084262801 1.0 0.9855498247806215 99.99768299833003 Annotation Cluster 45 Enrichment Score: 0.3185851327257597 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000139~Golgi membrane 4 2.2346368715083798 0.2817481099330903 GJA1, CYP2E1, MAN1C1, GJB2 128 186 12782 2.147513440860215 1.0 0.9658002343166253 98.44138806968364 GOTERM_CC_FAT GO:0044431~Golgi apparatus part 5 2.793296089385475 0.334771983507382 GJA1, CYP2E1, PCSK6, MAN1C1, GJB2 128 294 12782 1.6982886904761905 1.0 0.9640714626730679 99.40581007689974 GOTERM_CC_FAT GO:0005794~Golgi apparatus 11 6.145251396648044 0.3665107267759241 CYBA, GCNT3, GIMAP8, B3GNT7, F2RL1, GJA1, CYP2E1, PCSK6, MAN1C1, CD1E, GJB2 128 872 12782 1.2596939506880733 1.0 0.9682290643048519 99.67867049255116 GOTERM_CC_FAT GO:0012505~endomembrane system 7 3.910614525139665 0.7967955283116901 ATP11B, RYR2, GJA1, NAV3, CYP2E1, MAN1C1, GJB2 128 782 12782 0.8938818734015346 1.0 0.9993815181829986 99.9999998016018 GOTERM_CC_FAT GO:0031090~organelle membrane 8 4.4692737430167595 0.9268952181806774 ATP11B, RYR2, GJA1, NAV3, CYP2E1, MAN1C1, TLR9, GJB2 128 1096 12782 0.7289005474452555 1.0 0.9999650721440739 99.99999999999947 Annotation Cluster 46 Enrichment Score: 0.26870455176726366 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019953~sexual reproduction 6 3.35195530726257 0.37010952503728617 TXNDC3, DNAH9, ZP1, MAEL, SYT6, WDR33 119 458 13528 1.4892664489376537 1.0 0.9726661710914456 99.93434262625115 GOTERM_BP_FAT GO:0048232~male gamete generation 4 2.2346368715083798 0.50574881673219 TXNDC3, DNAH9, MAEL, WDR33 119 308 13528 1.4763723671286695 1.0 0.9876062840540187 99.99859575167753 GOTERM_BP_FAT GO:0007283~spermatogenesis 4 2.2346368715083798 0.50574881673219 TXNDC3, DNAH9, MAEL, WDR33 119 308 13528 1.4763723671286695 1.0 0.9876062840540187 99.99859575167753 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 5 2.793296089385475 0.6185806149132084 TXNDC3, DNAH9, PRLR, MAEL, WDR33 119 487 13528 1.1671526926992564 1.0 0.9948586795277392 99.99997693210796 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 5 2.793296089385475 0.6185806149132084 TXNDC3, DNAH9, PRLR, MAEL, WDR33 119 487 13528 1.1671526926992564 1.0 0.9948586795277392 99.99997693210796 GOTERM_BP_FAT GO:0007276~gamete generation 4 2.2346368715083798 0.6741865198022248 TXNDC3, DNAH9, MAEL, WDR33 119 395 13528 1.1511966812041272 1.0 0.9974539540989332 99.99999810342653 Annotation Cluster 47 Enrichment Score: 0.256900570062579 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011993:Pleckstrin homology-type 5 2.793296089385475 0.279107392304207 DOK2, MYO7B, FRMPD2, RASA3, ELMO2 148 303 16659 1.8574391222906077 1.0 0.984588326683925 98.87693795398306 UP_SEQ_FEATURE domain:PH 3 1.675977653631285 0.6318178951886582 DOK2, RASA3, ELMO2 173 237 19113 1.3984780859003438 1.0 0.9999999889214635 99.99996782547859 INTERPRO IPR001849:Pleckstrin homology 3 1.675977653631285 0.7049881963929368 DOK2, RASA3, ELMO2 148 277 16659 1.2190701531856767 1.0 0.9999923322742175 99.99999465729421 SMART SM00233:PH 3 1.675977653631285 0.7548360138175982 DOK2, RASA3, ELMO2 89 277 9079 1.1048148298381535 1.0 0.9999522215730445 99.99997862438794 Annotation Cluster 48 Enrichment Score: 0.23663048080617416 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS sh3 domain 3 1.675977653631285 0.5623792091010535 GRAP, MYO7B, MYO15A 173 210 19235 1.588356729975227 1.0 0.9842234293250444 99.99768569337522 INTERPRO IPR001452:Src homology-3 domain 3 1.675977653631285 0.5631377266609838 GRAP, MYO7B, MYO15A 148 213 16659 1.585363532546631 1.0 0.9998326530949283 99.99883429503504 SMART SM00326:SH3 3 1.675977653631285 0.6158354395000142 GRAP, MYO7B, MYO15A 89 213 9079 1.4367779711979745 1.0 0.9993474217113661 99.99710983573661 Annotation Cluster 49 Enrichment Score: 0.23532430176109012 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS actin-binding 4 2.2346368715083798 0.38041702470288763 MYO7B, MYO15A, POF1B, KLHL4 173 247 19235 1.800566333575156 1.0 0.9480863725213052 99.79357764651459 GOTERM_MF_FAT GO:0003779~actin binding 4 2.2346368715083798 0.6004666017853132 MYO7B, MYO15A, POF1B, KLHL4 124 326 12983 1.284682366910746 1.0 0.999381337455732 99.99954347003583 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 4 2.2346368715083798 0.8615456488002227 MYO7B, MYO15A, POF1B, KLHL4 124 504 12983 0.8309651817716335 1.0 0.9999421993639003 99.99999999969053 Annotation Cluster 50 Enrichment Score: 0.23384689419423327 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 3 1.675977653631285 0.33921699299383157 RYR2, RASA3, SCNN1B 124 127 12983 2.473266446532893 1.0 0.9968581719833485 99.61257940878322 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 3 1.675977653631285 0.33921699299383157 RYR2, RASA3, SCNN1B 124 127 12983 2.473266446532893 1.0 0.9968581719833485 99.61257940878322 GOTERM_MF_FAT GO:0015267~channel activity 6 3.35195530726257 0.3518232341225126 TTYH2, RYR2, RASA3, SCNN1B, GJA3, GJB2 124 412 12983 1.5247807704353271 1.0 0.9968760484638955 99.70073351954339 GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 6 3.35195530726257 0.35371024527265693 TTYH2, RYR2, RASA3, SCNN1B, GJA3, GJB2 124 413 12983 1.5210888073107867 1.0 0.996172213471165 99.71220258457998 GOTERM_BP_FAT GO:0015674~di-, tri-valent inorganic cation transport 3 1.675977653631285 0.45580189463924575 BSPRY, MFI2, RYR2 119 176 13528 1.937738731856379 1.0 0.9836738778891418 99.99353834510708 GOTERM_BP_FAT GO:0030001~metal ion transport 5 2.793296089385475 0.5818389030546645 BSPRY, SLC17A2, MFI2, RYR2, SCNN1B 119 465 13528 1.2223728200957804 1.0 0.9934964111461909 99.99990085221908 SP_PIR_KEYWORDS ion transport 6 3.35195530726257 0.5924592572030383 BSPRY, TTYH2, SLC17A2, MFI2, RYR2, SCNN1B 173 578 19235 1.1541692501550092 1.0 0.9867863019772336 99.99907749471771 GOTERM_CC_FAT GO:0034702~ion channel complex 3 1.675977653631285 0.607467829433805 TTYH2, RYR2, SCNN1B 128 205 12782 1.4613567073170732 1.0 0.9963419340176503 99.99921811320996 GOTERM_BP_FAT GO:0006811~ion transport 7 3.910614525139665 0.6671292583782464 BSPRY, TTYH2, SLC17A2, MFI2, ATP11B, RYR2, SCNN1B 119 768 13528 1.0361519607843137 1.0 0.9972318853867621 99.9999973360359 GOTERM_MF_FAT GO:0005216~ion channel activity 4 2.2346368715083798 0.7128688012690113 TTYH2, RYR2, RASA3, SCNN1B 124 386 12983 1.084990807287314 1.0 0.9997036824363869 99.99999454930635 GOTERM_BP_FAT GO:0006812~cation transport 5 2.793296089385475 0.7162476141405054 BSPRY, SLC17A2, MFI2, RYR2, SCNN1B 119 553 13528 1.0278541796465421 1.0 0.9985555377230216 99.99999978807487 GOTERM_MF_FAT GO:0022838~substrate specific channel activity 4 2.2346368715083798 0.7322019477747446 TTYH2, RYR2, RASA3, SCNN1B 124 398 12983 1.0522775166153346 1.0 0.999732874291522 99.99999785862857 GOTERM_MF_FAT GO:0005261~cation channel activity 3 1.675977653631285 0.7384037574024443 RYR2, RASA3, SCNN1B 124 275 12983 1.142199413489736 1.0 0.9997271620417932 99.9999984357704 SP_PIR_KEYWORDS ionic channel 3 1.675977653631285 0.7801364918536804 TTYH2, RYR2, SCNN1B 173 318 19235 1.0489148216817537 1.0 0.9985246022861917 99.99999968139704 GOTERM_MF_FAT GO:0022836~gated channel activity 3 1.675977653631285 0.7962833473041635 RYR2, RASA3, SCNN1B 124 310 12983 1.0132414151925078 1.0 0.9998047623887439 99.99999994521923 GOTERM_MF_FAT GO:0046873~metal ion transmembrane transporter activity 3 1.675977653631285 0.82144284595689 RYR2, RASA3, SCNN1B 124 328 12983 0.9576367033831629 1.0 0.999887155602563 99.9999999906396 SP_PIR_KEYWORDS transport 13 7.262569832402235 0.8239325256187346 RAMP3, RBP5, MFI2, FRRS1, CYBA, BSPRY, APOD, TTYH2, SLC17A2, FABP3, RYR2, SCNN1B, SCP2 173 1670 19235 0.8655117510643454 1.0 0.9988308188712387 99.9999999819203 Annotation Cluster 51 Enrichment Score: 0.2318814582103501 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:4 3 1.675977653631285 0.48741124637971495 MUC20, RYR2, MUC17 173 182 19113 1.821095089881217 1.0 0.999999587978751 99.99545409930735 UP_SEQ_FEATURE repeat:3 3 1.675977653631285 0.5761330760002557 MUC20, RYR2, MUC17 173 214 19113 1.5487818054129974 1.0 0.9999999649578646 99.99973534571501 UP_SEQ_FEATURE repeat:1 3 1.675977653631285 0.6453705250438754 MUC20, RYR2, MUC17 173 243 19113 1.3639477627916934 1.0 0.9999999906898558 99.99998164237822 UP_SEQ_FEATURE repeat:2 3 1.675977653631285 0.6519986339014936 MUC20, RYR2, MUC17 173 246 19113 1.3473142534893556 1.0 0.9999999890859761 99.99998615728951 Annotation Cluster 52 Enrichment Score: 0.2290548068521803 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 9 3 1.675977653631285 0.34335647617093173 LRRC4C, ECM2, TLR9 173 135 19113 2.4551059730250477 1.0 0.9999849511551098 99.81510672586417 UP_SEQ_FEATURE repeat:LRR 8 3 1.675977653631285 0.3893893366378375 LRRC4C, ECM2, TLR9 173 149 19113 2.224424874888466 1.0 0.9999963548845013 99.93767714115063 UP_SEQ_FEATURE repeat:LRR 7 3 1.675977653631285 0.4745052422819938 LRRC4C, ECM2, TLR9 173 177 19113 1.8725384540021555 1.0 0.9999997409415785 99.99340526666494 INTERPRO IPR001611:Leucine-rich repeat 3 1.675977653631285 0.5631377266609838 LRRC4C, ECM2, TLR9 148 213 16659 1.585363532546631 1.0 0.9998326530949283 99.99883429503504 UP_SEQ_FEATURE repeat:LRR 6 3 1.675977653631285 0.5658940967266166 LRRC4C, ECM2, TLR9 173 210 19113 1.578282411230388 1.0 0.9999999664717303 99.99962175299157 UP_SEQ_FEATURE repeat:LRR 5 3 1.675977653631285 0.6178677756341182 LRRC4C, ECM2, TLR9 173 231 19113 1.4348021920276255 1.0 0.9999999867644087 99.99994387451767 UP_SEQ_FEATURE repeat:LRR 4 3 1.675977653631285 0.6649605959407836 LRRC4C, ECM2, TLR9 173 252 19113 1.31523534269199 1.0 0.9999999908132653 99.99999215532823 UP_SEQ_FEATURE repeat:LRR 3 3 1.675977653631285 0.7534688163499966 LRRC4C, ECM2, TLR9 173 299 19113 1.108492663405958 1.0 0.9999999987955541 99.99999992032865 UP_SEQ_FEATURE repeat:LRR 1 3 1.675977653631285 0.7831405710908547 LRRC4C, ECM2, TLR9 173 318 19113 1.042261969680445 1.0 0.9999999992544929 99.99999998830431 UP_SEQ_FEATURE repeat:LRR 2 3 1.675977653631285 0.7846124266836879 LRRC4C, ECM2, TLR9 173 319 19113 1.0389946907786252 1.0 0.9999999989555436 99.99999998943733 SP_PIR_KEYWORDS leucine-rich repeat 3 1.675977653631285 0.7860051301263613 LRRC4C, ECM2, TLR9 173 322 19235 1.0358848238968872 1.0 0.9983491389472776 99.99999977535876 Annotation Cluster 53 Enrichment Score: 0.2237794946181973 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS magnesium 7 3.910614525139665 0.20482523785144918 FGFR2, ACSM1, ACVRL1, HPSE, ATP11B, ATP11A, ENTPD3 173 442 19235 1.760847958569822 1.0 0.8316640434941365 94.81946357218617 SP_PIR_KEYWORDS atp-binding 13 7.262569832402235 0.5259478463412279 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, ATP11B, ATP11A, RIOK2, ACSM1, MYO15A, ENTPD3, PGK2 173 1326 19235 1.0900487362575089 1.0 0.9799732360084155 99.99349915137199 GOTERM_MF_FAT GO:0005524~ATP binding 15 8.379888268156424 0.5416971833619142 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, PGK2 124 1477 12983 1.0633203747788673 1.0 0.9995478864553236 99.99712721914916 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 15 8.379888268156424 0.5629797302305323 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, PGK2 124 1497 12983 1.0491143577477535 1.0 0.9994185475202434 99.99848116615152 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 15 8.379888268156424 0.6442108031060158 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, PGK2 124 1577 12983 0.995893591343302 1.0 0.9993600258810016 99.99990351246596 SP_PIR_KEYWORDS nucleotide-binding 15 8.379888268156424 0.6540081989262103 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, GIMAP8, ATP11B, ATP11A, RIOK2, ACSM1, MYO15A, ENTPD3, TUBB1, PGK2 173 1686 19235 0.9891901343262091 1.0 0.9919822233350777 99.99988867986168 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 15 8.379888268156424 0.6670908894981766 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, PGK2 124 1601 12983 0.9809645181439021 1.0 0.9995235775351833 99.99996041276728 GOTERM_MF_FAT GO:0001882~nucleoside binding 15 8.379888268156424 0.6773156367472452 FGFR2, DNAH11, KIF12, DNAH9, ACVRL1, MYO7B, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, PGK2 124 1612 12983 0.9742705915312575 1.0 0.9995432381104046 99.99997394029282 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 17 9.497206703910614 0.6803412772528762 FGFR2, DNAH11, DNAH9, KIF12, ACVRL1, MYO7B, GIMAP8, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, TUBB1, PGK2 124 1836 12983 0.9694593787335721 1.0 0.999492905553352 99.99997703155921 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 17 9.497206703910614 0.6803412772528762 FGFR2, DNAH11, DNAH9, KIF12, ACVRL1, MYO7B, GIMAP8, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, TUBB1, PGK2 124 1836 12983 0.9694593787335721 1.0 0.999492905553352 99.99997703155921 GOTERM_MF_FAT GO:0000166~nucleotide binding 20 11.1731843575419 0.7416961211792471 FGFR2, DNAH11, DNAH9, KIF12, ACVRL1, MYO7B, GIMAP8, ATP11B, ATP11A, NAV3, RIOK2, CNOT4, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, TUBB1, HPGD, PGK2 124 2245 12983 0.9327537897837488 1.0 0.999652770501062 99.99999867999892 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 17 9.497206703910614 0.7472360297526836 FGFR2, DNAH11, DNAH9, KIF12, ACVRL1, MYO7B, GIMAP8, ATP11B, ATP11A, RIOK2, TXNDC3, ACSM1, MYO15A, SLFN12, ENTPD3, TUBB1, PGK2 124 1918 12983 0.9280122102997073 1.0 0.9996439382585209 99.99999901287671 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 8 4.4692737430167595 0.7683627869116654 DNAH11, FGFR2, KIF12, ACSM1, DNAH9, ACVRL1, MYO15A, PGK2 173 962 19113 0.9187506759761095 1.0 0.9999999987969402 99.99999996863951 Annotation Cluster 54 Enrichment Score: 0.21031250091809933 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS GTPase activation 3 1.675977653631285 0.4133475303785671 ARHGAP30, ARHGAP8, RASA3 173 159 19235 2.0978296433635073 1.0 0.9564957535177285 99.89804521110993 GOTERM_MF_FAT GO:0008047~enzyme activator activity 4 2.2346368715083798 0.6189952708641352 ARHGAP30, PRLR, ARHGAP8, RASA3 124 335 12983 1.250168512277323 1.0 0.9992547369954209 99.99975842313748 GOTERM_MF_FAT GO:0005096~GTPase activator activity 3 1.675977653631285 0.6200515406340394 ARHGAP30, ARHGAP8, RASA3 124 220 12983 1.42774926686217 1.0 0.9991330497935795 99.99976724705526 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 4 2.2346368715083798 0.7414827247526798 ARHGAP30, ARHGAP8, RASA3, PEX5L 124 404 12983 1.036649632705206 1.0 0.9997015047537566 99.99999866530726 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 4 2.2346368715083798 0.7549287919641243 ARHGAP30, ARHGAP8, RASA3, PEX5L 124 413 12983 1.0140592048738577 1.0 0.9995998301303644 99.9999993476816 Annotation Cluster 55 Enrichment Score: 0.20738203303330094 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003712~transcription cofactor activity 5 2.793296089385475 0.4519388448733719 TAF5L, BCL11A, PRRX1, FHL5, ZFPM2 124 363 12983 1.4421709766284547 1.0 0.9986011398165564 99.9684187601024 GOTERM_MF_FAT GO:0003713~transcription coactivator activity 3 1.675977653631285 0.6049394750887591 TAF5L, PRRX1, FHL5 124 214 12983 1.4677796201386795 1.0 0.9993155198788499 99.99960741459348 GOTERM_MF_FAT GO:0008134~transcription factor binding 5 2.793296089385475 0.7216456438000687 TAF5L, BCL11A, PRRX1, FHL5, ZFPM2 124 513 12983 1.020483556561655 1.0 0.9997120531099162 99.99999640463726 GOTERM_MF_FAT GO:0016563~transcription activator activity 4 2.2346368715083798 0.7505096437304106 TAF5L, PRRX1, TBX1, FHL5 124 410 12983 1.0214791502753737 1.0 0.999616906610488 99.99999917112413 Annotation Cluster 56 Enrichment Score: 0.2025793606543915 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Serine protease 3 1.675977653631285 0.34380379463064475 RHBDL2, PCSK6, PLG 173 136 19235 2.4526096565793947 1.0 0.9356947208653941 99.56668136539876 GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 3 1.675977653631285 0.4300090544439202 RHBDL2, PCSK6, PLG 124 154 12983 2.0396418098031 1.0 0.9986610830299087 99.94656715475736 GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 3 1.675977653631285 0.5049935544960789 RHBDL2, PCSK6, PLG 124 178 12983 1.7646339253352665 1.0 0.9994007362935551 99.99193216911098 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 3 1.675977653631285 0.5109544897123377 RHBDL2, PCSK6, PLG 124 180 12983 1.7450268817204302 1.0 0.9993217924546638 99.99314142453268 SP_PIR_KEYWORDS Protease 4 2.2346368715083798 0.811057783513289 F2RL1, RHBDL2, PCSK6, PLG 173 484 19235 0.9188840586633544 1.0 0.998616731778316 99.99999995501527 GOTERM_MF_FAT GO:0004175~endopeptidase activity 3 1.675977653631285 0.874572315437332 RHBDL2, PCSK6, PLG 124 375 12983 0.8376129032258064 1.0 0.9999339574293892 99.99999999991769 GOTERM_MF_FAT GO:0008233~peptidase activity 4 2.2346368715083798 0.913653601646004 F2RL1, RHBDL2, PCSK6, PLG 124 574 12983 0.7296279644824099 1.0 0.9999836657566213 99.99999999999945 GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 3 1.675977653631285 0.9689016630327028 RHBDL2, PCSK6, PLG 124 549 12983 0.5721399612198131 1.0 0.9999996809127347 100.0 Annotation Cluster 57 Enrichment Score: 0.17308556305703285 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006917~induction of apoptosis 4 2.2346368715083798 0.5315356408015162 RYR2, FASLG, MYC, PLG 119 320 13528 1.4210084033613444 1.0 0.989800902157789 99.99939955636277 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 4 2.2346368715083798 0.5336512177072025 RYR2, FASLG, MYC, PLG 119 321 13528 1.41658158590539 1.0 0.9898049266290319 99.9994411370498 GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 4 2.2346368715083798 0.6003560412881253 PRLR, MAEL, PCSK6, MYC 119 354 13528 1.2845273702701419 1.0 0.9945338678267643 99.99995164927694 GOTERM_BP_FAT GO:0008219~cell death 7 3.910614525139665 0.6030602234001481 LMX1B, HSPB8, GJA1, FASLG, MYC, ELMO2, PLG 119 719 13528 1.106765933076986 1.0 0.9945867815768866 99.99995658383216 GOTERM_BP_FAT GO:0016265~death 7 3.910614525139665 0.6098869828315788 LMX1B, HSPB8, GJA1, FASLG, MYC, ELMO2, PLG 119 724 13528 1.0991225219369516 1.0 0.994800054719571 99.99996702424953 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 4 2.2346368715083798 0.6099107359343482 PRLR, MAEL, PCSK6, MYC 119 359 13528 1.266637016923761 1.0 0.9946519213787114 99.99996705606974 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 4 2.2346368715083798 0.6118036116926094 PRLR, MAEL, PCSK6, MYC 119 360 13528 1.2631185807656395 1.0 0.9946452870476868 99.99996950132768 GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 4 2.2346368715083798 0.6267279876132468 HSPB8, GJA1, MYC, GJA3 119 368 13528 1.2356594811837778 1.0 0.995299104083432 99.9999836194941 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 7 3.910614525139665 0.7099201976890024 PRLR, MAEL, RYR2, FASLG, PCSK6, MYC, PLG 119 804 13528 0.9897570968685981 1.0 0.9984322784195381 99.99999969936178 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 7 3.910614525139665 0.718913326506337 PRLR, MAEL, RYR2, FASLG, PCSK6, MYC, PLG 119 812 13528 0.9800057954216169 1.0 0.9985783164772255 99.99999981753174 GOTERM_BP_FAT GO:0010941~regulation of cell death 7 3.910614525139665 0.7222367873889342 PRLR, MAEL, RYR2, FASLG, PCSK6, MYC, PLG 119 815 13528 0.9763984121255864 1.0 0.9986180634778782 99.99999984889244 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 4 2.2346368715083798 0.728978329561292 RYR2, FASLG, MYC, PLG 119 430 13528 1.0574946257572797 1.0 0.9987406688343 99.99999989764744 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 4 2.2346368715083798 0.7333252782570165 RYR2, FASLG, MYC, PLG 119 433 13528 1.0501678731538806 1.0 0.9988011658082065 99.99999992079364 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 4 2.2346368715083798 0.7361930552970437 RYR2, FASLG, MYC, PLG 119 435 13528 1.0453395151163913 1.0 0.998826803840631 99.9999999332718 GOTERM_BP_FAT GO:0006915~apoptosis 5 2.793296089385475 0.7761558992317992 GJA1, FASLG, MYC, ELMO2, PLG 119 602 13528 0.9441916301404283 1.0 0.99942978390161 99.99999999506619 GOTERM_BP_FAT GO:0012501~programmed cell death 5 2.793296089385475 0.7860166242779489 GJA1, FASLG, MYC, ELMO2, PLG 119 611 13528 0.9302837337881144 1.0 0.9995096207403669 99.99999999758474 GOTERM_BP_FAT GO:0010033~response to organic substance 5 2.793296089385475 0.8807037367480502 FABP3, RYR2, FASLG, CLEC7A, MYC 119 721 13528 0.7883541766221053 1.0 0.9999515460648116 99.99999999999977 Annotation Cluster 58 Enrichment Score: 0.16843661159882253 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005509~calcium ion binding 15 8.379888268156424 0.05234898180001768 EGFL6, CRP, SYT6, DLK1, MAN1C1, PLG, BSPRY, MCTP2, PRRG2, CRB2, HPSE, TTYH2, RYR2, ENTPD3, PCSK6 124 919 12983 1.708949068061357 0.9999999284811254 0.7461746135928646 51.35811981445209 GOTERM_MF_FAT GO:0043169~cation binding 36 20.11173184357542 0.8382227671912292 ACVRL1, CRP, SYT6, ADH1A, FHL5, ZNF366, DLK1, CNOT4, MCTP2, HPSE, PRRG2, CRB2, TTYH2, CH25H, BCL11A, ENTPD3, PCSK6, SCNN1B, RASA3, IKZF3, LMX1B, KLB, EGFL6, MFI2, ATP11B, ATP11A, CYP2E1, MAN1C1, PLG, FRRS1, CYBA, BSPRY, ACSM1, SLC17A2, RYR2, ZFPM2 124 4179 12983 0.9019521570988585 1.0 0.999892448011185 99.9999999975064 GOTERM_MF_FAT GO:0043167~ion binding 36 20.11173184357542 0.8642594826886373 ACVRL1, CRP, SYT6, ADH1A, FHL5, ZNF366, DLK1, CNOT4, MCTP2, HPSE, PRRG2, CRB2, TTYH2, CH25H, BCL11A, ENTPD3, PCSK6, SCNN1B, RASA3, IKZF3, LMX1B, KLB, EGFL6, MFI2, ATP11B, ATP11A, CYP2E1, MAN1C1, PLG, FRRS1, CYBA, BSPRY, ACSM1, SLC17A2, RYR2, ZFPM2 124 4241 12983 0.8887663439085427 1.0 0.9999387020228803 99.99999999976265 GOTERM_MF_FAT GO:0046872~metal ion binding 35 19.553072625698324 0.8676961380136492 ACVRL1, CRP, SYT6, ADH1A, FHL5, ZNF366, DLK1, CNOT4, MCTP2, HPSE, PRRG2, CRB2, TTYH2, CH25H, BCL11A, ENTPD3, PCSK6, SCNN1B, RASA3, IKZF3, LMX1B, EGFL6, MFI2, ATP11B, ATP11A, CYP2E1, MAN1C1, PLG, FRRS1, CYBA, BSPRY, ACSM1, SLC17A2, RYR2, ZFPM2 124 4140 12983 0.8851585631915226 1.0 0.9999369015605145 99.99999999983169 SP_PIR_KEYWORDS metal-binding 21 11.731843575418994 0.9376088736126936 IKZF3, ACVRL1, LMX1B, MFI2, CRP, ATP11B, ATP11A, ZNF366, FHL5, SYT6, ADH1A, CYP2E1, CNOT4, FRRS1, CYBA, BSPRY, ACSM1, CH25H, BCL11A, ZFPM2, RASA3 173 2972 19235 0.7856273193349878 1.0 0.9999381042419696 99.99999999999997 SP_PIR_KEYWORDS zinc-finger 8 4.4692737430167595 0.9955911085994518 IKZF3, BSPRY, BCL11A, ZNF366, FHL5, ZFPM2, RASA3, CNOT4 173 1718 19235 0.5177414253702719 1.0 0.9999999661121084 100.0 SP_PIR_KEYWORDS zinc 11 6.145251396648044 0.9957588492566597 IKZF3, BSPRY, LMX1B, BCL11A, MFI2, ZNF366, FHL5, ZFPM2, ADH1A, RASA3, CNOT4 173 2189 19235 0.5587184477299794 1.0 0.999999953276755 100.0 GOTERM_MF_FAT GO:0046914~transition metal ion binding 16 8.938547486033519 0.9973043556568421 IKZF3, ACVRL1, LMX1B, MFI2, ZNF366, FHL5, ADH1A, CYP2E1, CNOT4, FRRS1, CYBA, BSPRY, CH25H, BCL11A, ZFPM2, RASA3 124 2785 12983 0.6015173452249957 1.0 0.9999999999830215 100.0 GOTERM_MF_FAT GO:0008270~zinc ion binding 11 6.145251396648044 0.9993241376533593 IKZF3, BSPRY, LMX1B, BCL11A, MFI2, ZNF366, FHL5, ZFPM2, ADH1A, RASA3, CNOT4 124 2311 12983 0.49836336734551445 1.0 0.9999999999999222 100.0 Annotation Cluster 59 Enrichment Score: 0.10066181440648572 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cell junction 5 2.793296089385475 0.4797403837684815 GJA1, AMOT, SYT6, GJA3, GJB2 173 399 19235 1.3932953771712517 1.0 0.9743248644815438 99.97838780494466 GOTERM_CC_FAT GO:0030054~cell junction 5 2.793296089385475 0.7622364876089731 GJA1, AMOT, SYT6, GJA3, GJB2 128 518 12782 0.963893581081081 1.0 0.9990670719476055 99.99999857019878 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 5 2.793296089385475 0.8870458206493557 CYBA, GJA1, AMOT, FASLG, SYT6 128 642 12782 0.7777209890965732 1.0 0.9999225193988224 99.99999999987679 GOTERM_CC_FAT GO:0031982~vesicle 5 2.793296089385475 0.905739451242085 CYBA, GJA1, AMOT, FASLG, SYT6 128 670 12782 0.7452192164179104 1.0 0.9999562576263515 99.99999999998734 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 4 2.2346368715083798 0.9152179781862403 CYBA, GJA1, FASLG, SYT6 128 550 12782 0.7262500000000001 1.0 0.9999654662084652 99.99999999999666 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 4 2.2346368715083798 0.9256764599880413 CYBA, GJA1, FASLG, SYT6 128 568 12782 0.7032350352112676 1.0 0.999969485549948 99.99999999999936 Annotation Cluster 60 Enrichment Score: 0.09899345918185774 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007167~enzyme linked receptor protein signaling pathway 5 2.793296089385475 0.34888786673946426 FGFR2, DOK2, ACVRL1, PRLR, HPGD 119 342 13528 1.661998132586368 1.0 0.9689802009715356 99.88896666796792 SP_PIR_KEYWORDS ATP 3 1.675977653631285 0.6260529458700633 FGFR2, ACVRL1, PGK2 173 236 19235 1.4133682766728715 1.0 0.989525357899218 99.99969632066001 UP_SEQ_FEATURE binding site:ATP 5 2.793296089385475 0.7225761599643199 FGFR2, ACSM1, ACVRL1, RIOK2, PGK2 173 542 19113 1.0191860589126123 1.0 0.9999999989136419 99.99999953396033 GOTERM_MF_FAT GO:0004672~protein kinase activity 5 2.793296089385475 0.8320539742022688 NRP2, FGFR2, ACVRL1, HSPB8, RIOK2 124 606 12983 0.863874693921005 1.0 0.9998882196076023 99.9999999958822 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 7 3.910614525139665 0.8602742550065045 FGFR2, ACVRL1, PRLR, SLC17A2, PTPN22, RIOK2, PGK2 119 973 13528 0.8178465630856658 1.0 0.9999106910854204 99.99999999999719 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 7 3.910614525139665 0.8602742550065045 FGFR2, ACVRL1, PRLR, SLC17A2, PTPN22, RIOK2, PGK2 119 973 13528 0.8178465630856658 1.0 0.9999106910854204 99.99999999999719 GOTERM_BP_FAT GO:0016310~phosphorylation 5 2.793296089385475 0.9242200988960583 FGFR2, ACVRL1, PRLR, RIOK2, PGK2 119 800 13528 0.7105042016806724 1.0 0.9999927896999914 100.0 UP_SEQ_FEATURE domain:Protein kinase 3 1.675977653631285 0.9266468049873207 FGFR2, ACVRL1, RIOK2 173 469 19113 0.7066936169688305 1.0 0.9999999999999757 100.0 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 4 2.2346368715083798 0.934958198523548 FGFR2, ACVRL1, PRLR, RIOK2 119 667 13528 0.6817431620324291 1.0 0.999996004220054 100.0 SP_PIR_KEYWORDS transferase 9 5.027932960893855 0.9369050347543825 FGFR2, GCNT3, LRAT, ACVRL1, B3GNT7, HS6ST2, RIOK2, SCP2, PGK2 173 1394 19235 0.7178369726573839 1.0 0.9999441478289903 99.99999999999997 UP_SEQ_FEATURE active site:Proton acceptor 4 2.2346368715083798 0.9384164410706369 FGFR2, ACVRL1, HPGD, RIOK2 173 658 19113 0.6716095366937821 1.0 0.9999999999999946 100.0 SP_PIR_KEYWORDS kinase 4 2.2346368715083798 0.9481991533056735 FGFR2, ACVRL1, RIOK2, PGK2 173 688 19235 0.6464242505713134 1.0 0.9999625332976856 100.0 Annotation Cluster 61 Enrichment Score: 0.06717390977124159 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS gtp-binding 3 1.675977653631285 0.795946249287615 ACSM1, GIMAP8, TUBB1 173 329 19235 1.013844721260783 1.0 0.9984847576295314 99.99999987847639 GOTERM_MF_FAT GO:0005525~GTP binding 3 1.675977653631285 0.8716666553446097 ACSM1, GIMAP8, TUBB1 124 372 12983 0.8443678459937565 1.0 0.9999365638547617 99.99999999988812 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 3 1.675977653631285 0.881120070227426 ACSM1, GIMAP8, TUBB1 124 382 12983 0.8222639756797837 1.0 0.9999403144976249 99.99999999995988 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 3 1.675977653631285 0.881120070227426 ACSM1, GIMAP8, TUBB1 124 382 12983 0.8222639756797837 1.0 0.9999403144976249 99.99999999995988 Annotation Cluster 62 Enrichment Score: 0.05319814925769777 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 3 1.675977653631285 0.6780778034012538 HOXA2, MAEL, ZFPM2 119 266 13528 1.2821128451380552 1.0 0.9975363026178741 99.9999984324023 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 4 2.2346368715083798 0.821027065042319 HOXA2, MAEL, ZFPM2, MYC 119 504 13528 0.9022275576897425 1.0 0.9997426133542554 99.99999999985786 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 3 1.675977653631285 0.8211877782458259 HOXA2, MAEL, ZFPM2 119 356 13528 0.957983193277311 1.0 0.9997336728472151 99.99999999985988 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 3 1.675977653631285 0.8283493202328216 HOXA2, MAEL, ZFPM2 119 362 13528 0.9421050188031014 1.0 0.9997722388532078 99.9999999999267 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 3 1.675977653631285 0.9133674721430145 HOXA2, MAEL, ZFPM2 119 459 13528 0.743010929862141 1.0 0.9999873277928841 100.0 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3 1.675977653631285 0.9412979522077874 HOXA2, MAEL, ZFPM2 119 512 13528 0.6660976890756302 1.0 0.9999971936725442 100.0 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 3 1.675977653631285 0.9442787297191565 HOXA2, MAEL, ZFPM2 119 519 13528 0.657113712537038 1.0 0.999997651534064 100.0 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 3 1.675977653631285 0.9548326424253007 HOXA2, MAEL, ZFPM2 119 547 13528 0.6234771788057089 1.0 0.9999989680024189 100.0 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 4 2.2346368715083798 0.9584162041927689 HOXA2, MAEL, ZFPM2, MYC 119 734 13528 0.619513200375518 1.0 0.9999991933789519 100.0 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 3 1.675977653631285 0.9593705321759083 HOXA2, MAEL, ZFPM2 119 561 13528 0.6079180335235699 1.0 0.9999992265839394 100.0 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 3 1.675977653631285 0.9629122611936588 HOXA2, MAEL, ZFPM2 119 573 13528 0.5951867658057988 1.0 0.999999449009826 100.0 Annotation Cluster 63 Enrichment Score: 0.050469841004105356 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 3 1.675977653631285 0.7775450529985724 RYR2, NAV3, CYP2E1 128 284 12782 1.0548525528169013 1.0 0.9991998066684281 99.999999380801 GOTERM_CC_FAT GO:0012505~endomembrane system 7 3.910614525139665 0.7967955283116901 ATP11B, RYR2, GJA1, NAV3, CYP2E1, MAN1C1, GJB2 128 782 12782 0.8938818734015346 1.0 0.9993815181829986 99.9999998016018 GOTERM_CC_FAT GO:0031090~organelle membrane 8 4.4692737430167595 0.9268952181806774 ATP11B, RYR2, GJA1, NAV3, CYP2E1, MAN1C1, TLR9, GJB2 128 1096 12782 0.7289005474452555 1.0 0.9999650721440739 99.99999999999947 GOTERM_CC_FAT GO:0031967~organelle envelope 3 1.675977653631285 0.9867833474288275 ATP11B, GJA1, NAV3 128 620 12782 0.4831905241935484 1.0 0.999999920197875 100.0 GOTERM_CC_FAT GO:0031975~envelope 3 1.675977653631285 0.9870198587388817 ATP11B, GJA1, NAV3 128 622 12782 0.4816368569131833 1.0 0.9999998995426207 100.0 Annotation Cluster 64 Enrichment Score: 0.018853225988573582 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C2H2-type 1 4 2.2346368715083798 0.8695304283716719 IKZF3, BCL11A, ZNF366, ZFPM2 173 542 19113 0.8153488471300897 1.0 0.999999999996422 99.99999999999416 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 4 2.2346368715083798 0.9142988249248036 IKZF3, BCL11A, ZNF366, ZFPM2 173 608 19113 0.7268405841192576 1.0 0.9999999999999484 99.99999999999999 INTERPRO IPR007087:Zinc finger, C2H2-type 5 2.793296089385475 0.9198458889165088 IKZF3, BCL11A, ZNF366, ZFPM2, PCSK6 148 784 16659 0.7178623138444568 1.0 0.9999999999073799 99.99999999999991 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 4 2.2346368715083798 0.9217959150414076 IKZF3, BCL11A, ZNF366, ZFPM2 173 622 19113 0.7104808282066055 1.0 0.9999999999999702 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 3 1.675977653631285 0.9565857829194296 IKZF3, BCL11A, ZNF366 173 538 19113 0.6160581902572146 1.0 0.9999999999999997 100.0 INTERPRO IPR015880:Zinc finger, C2H2-like 4 2.2346368715083798 0.974142865563988 IKZF3, BCL11A, ZNF366, ZFPM2 148 797 16659 0.5649225134796027 1.0 0.9999999999999932 100.0 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 3 1.675977653631285 0.9752985719109688 IKZF3, BCL11A, ZNF366 148 621 16659 0.5437720329024678 1.0 0.9999999999999899 100.0 SMART SM00355:ZnF_C2H2 4 2.2346368715083798 0.9864831369331006 IKZF3, BCL11A, ZNF366, ZFPM2 89 797 9079 0.5119760901132054 1.0 0.9999999999994785 100.0 GOTERM_BP_FAT GO:0006350~transcription 11 6.145251396648044 0.9920261025269854 IKZF3, HOXA2, TAF5L, LMX1B, BCL11A, ZNF366, TBX1, ZFPM2, MYC, FOXR1, CNOT4 119 2101 13528 0.5951867658057988 1.0 0.999999998672248 100.0 SP_PIR_KEYWORDS zinc-finger 8 4.4692737430167595 0.9955911085994518 IKZF3, BSPRY, BCL11A, ZNF366, FHL5, ZFPM2, RASA3, CNOT4 173 1718 19235 0.5177414253702719 1.0 0.9999999661121084 100.0 SP_PIR_KEYWORDS zinc 11 6.145251396648044 0.9957588492566597 IKZF3, BSPRY, LMX1B, BCL11A, MFI2, ZNF366, FHL5, ZFPM2, ADH1A, RASA3, CNOT4 173 2189 19235 0.5587184477299794 1.0 0.999999953276755 100.0 GOTERM_MF_FAT GO:0008270~zinc ion binding 11 6.145251396648044 0.9993241376533593 IKZF3, BSPRY, LMX1B, BCL11A, MFI2, ZNF366, FHL5, ZFPM2, ADH1A, RASA3, CNOT4 124 2311 12983 0.49836336734551445 1.0 0.9999999999999222 100.0 Annotation Cluster 65 Enrichment Score: 0.012834937699551081 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 4 2.2346368715083798 0.9558005968657954 HECW2, MYC, PLG, CNOT4 119 725 13528 0.6272037090698348 1.0 0.9999990050680454 100.0 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 3 1.675977653631285 0.9698374327231956 HECW2, PLG, CNOT4 119 600 13528 0.5684033613445378 1.0 0.9999997461287216 100.0 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 4 2.2346368715083798 0.9698904456079855 HECW2, MYC, PLG, CNOT4 119 781 13528 0.5822313560507429 1.0 0.9999997314498387 100.0 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 3 1.675977653631285 0.9705258150930357 HECW2, PLG, CNOT4 119 603 13528 0.5655754839249132 1.0 0.9999997389771343 100.0 GOTERM_BP_FAT GO:0030163~protein catabolic process 3 1.675977653631285 0.9745491229642426 HECW2, PLG, CNOT4 119 622 13528 0.5482990623902294 1.0 0.9999998517162852 100.0 GOTERM_BP_FAT GO:0006508~proteolysis 5 2.793296089385475 0.9848965724970405 HECW2, CRP, PCSK6, PLG, CNOT4 119 1054 13528 0.5392821265128442 1.0 0.9999999815993493 100.0 Annotation Cluster 66 Enrichment Score: 2.321189663823671E-6 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 5 2.793296089385475 0.9999917236812114 ACSM1, TAF5L, PCSK6, HPGD, MYC 128 1779 12782 0.2806615373805509 1.0 1.0 100.0 GOTERM_CC_FAT GO:0043233~organelle lumen 5 2.793296089385475 0.9999944585621614 ACSM1, TAF5L, PCSK6, HPGD, MYC 128 1820 12782 0.2743389423076923 1.0 1.0 100.0 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 5 2.793296089385475 0.9999961136393274 ACSM1, TAF5L, PCSK6, HPGD, MYC 128 1856 12782 0.26901771282327586 1.0 1.0 100.0 GOTERM_CC_FAT GO:0031981~nuclear lumen 3 1.675977653631285 0.9999963252343349 TAF5L, HPGD, MYC 128 1450 12782 0.20660560344827586 1.0 1.0 100.0