Annotation Cluster 1 Enrichment Score: 0.7718688894477134 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045941~positive regulation of transcription 4 12.5 0.03536543102559215 EGR1, EGR2, NR4A1, CDK2 22 475 13588 5.201148325358852 0.9999781162988989 0.9999781162988989 38.162318425827316 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 4 12.5 0.037866578327603824 EGR1, EGR2, NR4A1, CDK2 22 488 13588 5.062593144560358 0.9999899046889855 0.9968226880835331 40.26876572847318 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4 12.5 0.04230502624099974 EGR1, EGR2, NR4A1, CDK2 22 510 13588 4.844206773618539 0.9999974548814095 0.9863467510932025 43.84419294476568 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 4 12.5 0.04569418014651698 EGR1, EGR2, NR4A1, CDK2 22 526 13588 4.696854476322157 0.9999991150951572 0.9693292678717139 46.43988822936696 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 4 12.5 0.046562520410495946 EGR1, EGR2, NR4A1, CDK2 22 530 13588 4.661406518010292 0.999999325345273 0.9416801613847544 47.08683232164035 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 4 12.5 0.0514876198280768 EGR1, EGR2, NR4A1, CDK2 22 552 13588 4.47562582345191 0.9999998558498429 0.9275893376489786 50.62147695417618 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 4 12.5 0.05264193539967013 EGR1, EGR2, NR4A1, CDK2 22 557 13588 4.435449649094173 0.9999998997190045 0.8999599060359108 51.417673635987796 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 4 12.5 0.07173902819818874 EGR1, EGR2, NR4A1, CDK2 22 633 13588 3.902915410024415 0.9999999997678936 0.891215074905721 62.981788979763124 SP_PIR_KEYWORDS transcription regulation 6 18.75 0.07891271217809605 EGR1, EGR2, BTG2, PARP14, NR4A1, JUNB 28 1546 17854 2.4746812049528737 0.9983576659192734 0.9983576659192734 58.083915176414244 UP_SEQ_FEATURE compositionally biased region:Poly-Pro 3 9.375 0.09595018819310197 EGR2, GRIN2D, NR4A1 26 336 16021 5.501717032967034 0.9999832132256411 0.9959028333742841 67.94585950541125 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 3 9.375 0.10471110088050245 EGR1, EGR2, NR4A1 22 358 13588 5.175723717623159 0.9999999999999951 0.905048377150044 77.15779630831369 GOTERM_MF_FAT GO:0003700~transcription factor activity 4 12.5 0.10803005400619922 EGR1, EGR2, NR4A1, JUNB 21 776 13288 3.2616593028964163 0.9999729466918287 0.9999729466918287 71.31963595726823 GOTERM_BP_FAT GO:0045449~regulation of transcription 7 21.875 0.11583472104473004 EGR1, EGR2, BTG2, PARP14, NR4A1, JUNB, CDK2 22 2227 13588 1.9413805772135364 0.9999999999999999 0.8990315656173382 80.66900378236923 SP_PIR_KEYWORDS Transcription 6 18.75 0.12277592387189584 EGR1, EGR2, BTG2, PARP14, NR4A1, JUNB 28 1769 17854 2.1627230881046597 0.9999634722994997 0.9939561849382716 74.9830461452249 GOTERM_MF_FAT GO:0000287~magnesium ion binding 3 9.375 0.12489968514659912 RPS6KA1, GRIN2D, ATP7B 21 409 13288 4.641285365001746 0.9999953299525967 0.9978389707536929 76.71952643144418 GOTERM_BP_FAT GO:0007610~behavior 3 9.375 0.12845357419720804 EGR1, EGR2, GRIN2D 22 405 13588 4.575084175084175 1.0 0.91018930702401 84.04433439435948 GOTERM_BP_FAT GO:0006350~transcription 6 18.75 0.12875208581331052 EGR1, EGR2, BTG2, PARP14, NR4A1, JUNB 22 1772 13588 2.091319515698748 1.0 0.8979028922059267 84.11713396290276 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 3 9.375 0.13419129844661198 EGR1, EGR2, NR4A1 22 416 13588 4.454108391608391 1.0 0.895645151813858 85.39097835920715 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 3 9.375 0.13576688794525532 EGR1, EGR2, NR4A1 22 419 13588 4.422217400737686 1.0 0.8862895347900378 85.74191593890895 GOTERM_BP_FAT GO:0010033~response to organic substance 3 9.375 0.18257643040371505 EGR1, EGR2, ATP7B 22 505 13588 3.6691269126912687 1.0 0.9427753095758882 93.22010593220817 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 3 9.375 0.2460855900314602 EGR1, EGR2, NR4A1 22 616 13588 3.007969303423849 1.0 0.9742652235524113 97.69684015257172 GOTERM_MF_FAT GO:0030528~transcription regulator activity 4 12.5 0.2707467049654362 EGR1, EGR2, NR4A1, JUNB 21 1206 13288 2.0987127852799494 0.9999999999997574 0.9999376354772698 96.82334561270387 SP_PIR_KEYWORDS zinc-finger 4 12.5 0.273065507385844 RFWD2, EGR1, EGR2, NR4A1 28 1204 17854 2.1184148077835787 0.9999999999842735 0.9841715425632679 96.57292133420657 SP_PIR_KEYWORDS dna-binding 4 12.5 0.35789131011789427 EGR1, EGR2, NR4A1, JUNB 28 1404 17854 1.8166463166463165 0.999999999999999 0.9866898381246354 99.07759685547808 GOTERM_MF_FAT GO:0008270~zinc ion binding 5 15.625 0.393267151255986 RFWD2, EGR1, EGR2, NR4A1, ATP7B 21 2105 13288 1.5029973984843341 1.0 0.996804996434597 99.5741223151856 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 4 12.5 0.3983298088629912 EGR1, EGR2, NR4A1, JUNB 22 1465 13588 1.6863791498603786 1.0 0.9976560234264471 99.8866111300245 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 4 12.5 0.4083937772836297 EGR1, EGR2, NR4A1, JUNB 22 1488 13588 1.6603128054740959 1.0 0.9969526886069433 99.90947345017992 GOTERM_MF_FAT GO:0003677~DNA binding 4 12.5 0.5137951598598509 EGR1, EGR2, NR4A1, JUNB 21 1781 13288 1.4211384722333626 1.0 0.993923631263907 99.9621074213205 GOTERM_MF_FAT GO:0046872~metal ion binding 7 21.875 0.5437404252666476 RFWD2, EGR1, EGR2, RPS6KA1, GRIN2D, NR4A1, ATP7B 21 3850 13288 1.1504761904761904 1.0 0.9942384949994344 99.98107877387515 GOTERM_MF_FAT GO:0043169~cation binding 7 21.875 0.5541127476471057 RFWD2, EGR1, EGR2, RPS6KA1, GRIN2D, NR4A1, ATP7B 21 3885 13288 1.14011154011154 1.0 0.9929436462403246 99.98528217216838 SP_PIR_KEYWORDS zinc 4 12.5 0.554221746567015 RFWD2, EGR1, EGR2, NR4A1 28 1886 17854 1.3523708529010754 1.0 0.9967496220407369 99.98057110967554 GOTERM_MF_FAT GO:0043167~ion binding 7 21.875 0.5685098896111539 RFWD2, EGR1, EGR2, RPS6KA1, GRIN2D, NR4A1, ATP7B 21 3934 13288 1.1259108625656669 1.0 0.992036896396918 99.98971702189792 GOTERM_MF_FAT GO:0046914~transition metal ion binding 5 15.625 0.5722346152277621 RFWD2, EGR1, EGR2, NR4A1, ATP7B 21 2608 13288 1.2131171486999708 1.0 0.9899034804980147 99.99064627375509 SP_PIR_KEYWORDS metal-binding 5 15.625 0.5941904499978135 RFWD2, EGR1, EGR2, NR4A1, ATP7B 28 2682 17854 1.188745072973261 1.0 0.9971549185073805 99.99280701149425 SP_PIR_KEYWORDS nucleus 6 18.75 0.7121794213599918 RFWD2, EGR1, EGR2, PARP14, NR4A1, JUNB 28 3808 17854 1.0046893757503 1.0 0.9990305264234963 99.9998100250062 Annotation Cluster 2 Enrichment Score: 0.7697440718182207 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 3 9.375 0.06074641306813119 EGR2, GRIN2D, ATP7B 22 261 13588 7.099268547544408 0.999999992250156 0.9031361738787129 56.68205914621001 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 3 9.375 0.0636454540831645 EGR2, GRIN2D, ATP7B 22 268 13588 6.913839891451831 0.9999999969152759 0.8866667426522352 58.43328277422404 GOTERM_BP_FAT GO:0050801~ion homeostasis 3 9.375 0.07437651046550119 EGR2, GRIN2D, ATP7B 22 293 13588 6.323921811976419 0.9999999999005874 0.8767813369230919 64.36151247119341 GOTERM_BP_FAT GO:0019725~cellular homeostasis 3 9.375 0.09742959686820483 EGR2, GRIN2D, ATP7B 22 343 13588 5.402067320434667 0.9999999999999459 0.9046129189984045 74.54930378696677 GOTERM_BP_FAT GO:0048878~chemical homeostasis 3 9.375 0.10816112818499982 EGR2, GRIN2D, ATP7B 22 365 13588 5.076463262764632 0.9999999999999984 0.8971139644192566 78.30529665493796 GOTERM_BP_FAT GO:0042592~homeostatic process 3 9.375 0.2275566987288772 EGR2, GRIN2D, ATP7B 22 584 13588 3.172789539227895 1.0 0.9697237362489174 96.81515998385092 GOTERM_MF_FAT GO:0046872~metal ion binding 7 21.875 0.5437404252666476 RFWD2, EGR1, EGR2, RPS6KA1, GRIN2D, NR4A1, ATP7B 21 3850 13288 1.1504761904761904 1.0 0.9942384949994344 99.98107877387515 GOTERM_MF_FAT GO:0043169~cation binding 7 21.875 0.5541127476471057 RFWD2, EGR1, EGR2, RPS6KA1, GRIN2D, NR4A1, ATP7B 21 3885 13288 1.14011154011154 1.0 0.9929436462403246 99.98528217216838 GOTERM_MF_FAT GO:0043167~ion binding 7 21.875 0.5685098896111539 RFWD2, EGR1, EGR2, RPS6KA1, GRIN2D, NR4A1, ATP7B 21 3934 13288 1.1259108625656669 1.0 0.992036896396918 99.98971702189792 Annotation Cluster 3 Enrichment Score: 0.530926064987621 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007610~behavior 3 9.375 0.12845357419720804 EGR1, EGR2, GRIN2D 22 405 13588 4.575084175084175 1.0 0.91018930702401 84.04433439435948 GOTERM_BP_FAT GO:0050890~cognition 4 12.5 0.40489675832677086 EGR1, EGR2, OLFR869, GRIN2D 22 1480 13588 1.6692874692874693 1.0 0.9973909574610876 99.90206344221487 GOTERM_BP_FAT GO:0050877~neurological system process 4 12.5 0.49105632845612235 EGR1, EGR2, OLFR869, GRIN2D 22 1681 13588 1.4696879563030665 1.0 0.9990322158910809 99.98785997537757 Annotation Cluster 4 Enrichment Score: 0.4157044053225303 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS nucleotide-binding 5 15.625 0.22943578423282598 KIF14, RAB31, RPS6KA1, CDK2, ATP7B 28 1631 17854 1.9547604449505125 0.9999999985171771 0.9828518269978 93.65128289941178 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 5 15.625 0.28117172880254415 KIF14, RAB31, RPS6KA1, CDK2, ATP7B 21 1796 13288 1.7615865945487323 0.9999999999999355 0.9994960604593284 97.28572233960787 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 5 15.625 0.28117172880254415 KIF14, RAB31, RPS6KA1, CDK2, ATP7B 21 1796 13288 1.7615865945487323 0.9999999999999355 0.9994960604593284 97.28572233960787 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 5 15.625 0.30789422790809184 KIF14, RAB31, RPS6KA1, CDK2, ATP7B 21 1871 13288 1.6909724873380672 0.999999999999998 0.9988540294140149 98.20563174785099 SP_PIR_KEYWORDS atp-binding 4 12.5 0.30807812579350524 KIF14, RPS6KA1, CDK2, ATP7B 28 1287 17854 1.9817959817959816 0.9999999999996655 0.9834887986386054 97.96691839440176 GOTERM_MF_FAT GO:0005524~ATP binding 4 12.5 0.37221043193776104 KIF14, RPS6KA1, CDK2, ATP7B 21 1443 13288 1.754017754017754 1.0 0.9992060080121804 99.3817650445901 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 4 12.5 0.3795221101406852 KIF14, RPS6KA1, CDK2, ATP7B 21 1460 13288 1.733594259621657 1.0 0.9981127409847756 99.45603571937141 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 4 12.5 0.41164996220803785 KIF14, RPS6KA1, CDK2, ATP7B 21 1535 13288 1.6488909570342793 1.0 0.9955826093333418 99.6956941173227 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 4 12.5 0.4171886840457529 KIF14, RPS6KA1, CDK2, ATP7B 21 1548 13288 1.6350436815553093 1.0 0.9930360222531138 99.72556896459275 GOTERM_MF_FAT GO:0001882~nucleoside binding 4 12.5 0.4214416370476212 KIF14, RPS6KA1, CDK2, ATP7B 21 1558 13288 1.6245491778226053 1.0 0.9897113546808877 99.74667180472827 GOTERM_MF_FAT GO:0000166~nucleotide binding 5 15.625 0.4218965480629263 KIF14, RAB31, RPS6KA1, CDK2, ATP7B 21 2183 13288 1.4492943306502626 1.0 0.9850246845281674 99.74883942675172 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 3 9.375 0.7289086670069783 KIF14, RPS6KA1, CDK2 17 1919 12504 1.1498635931704626 1.0 1.0 99.99980097323794 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 3 9.375 0.7289086670069783 KIF14, RPS6KA1, CDK2 17 1919 12504 1.1498635931704626 1.0 1.0 99.99980097323794 Annotation Cluster 5 Enrichment Score: 0.23795364249130213 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006811~ion transport 4 12.5 0.09451428341415466 GRIN2D, SLC22A7, CDK2, ATP7B 22 712 13588 3.4698672114402456 0.9999999999998586 0.9150376532612737 73.42974636355237 SP_PIR_KEYWORDS ion transport 3 9.375 0.197734862857224 GRIN2D, SLC22A7, ATP7B 28 543 17854 3.522888713496448 0.999999965581038 0.9863792995396319 90.27490978336309 GOTERM_CC_FAT GO:0044459~plasma membrane part 3 9.375 0.6375518430562497 RAB31, GRIN2D, SLC22A7 17 1633 12504 1.3512481538849468 1.0 1.0 99.99630692185025 SP_PIR_KEYWORDS transport 3 9.375 0.7003938133933038 GRIN2D, SLC22A7, ATP7B 28 1571 17854 1.2176502682549786 1.0 0.9992767229889109 99.99970956007871 SP_PIR_KEYWORDS cell membrane 3 9.375 0.7464445135394482 RAB31, GRIN2D, SLC22A7 28 1713 17854 1.1167125344008004 1.0 0.9992035112170862 99.99995029493273 GOTERM_CC_FAT GO:0005886~plasma membrane 4 12.5 0.7555067851466886 RAB31, GRIN2D, SLC22A7, ATP7B 17 2906 12504 1.0124286466134973 1.0 0.9999999999996357 99.99992955142382 GOTERM_CC_FAT GO:0016021~integral to membrane 7 21.875 0.8169804631286499 OLFR869, GRIN2D, SLC22A7, 1700093K21RIK, AI118078, GM364, ATP7B 17 5709 12504 0.901857747828506 1.0 0.9999999999943365 99.99999617153426 SP_PIR_KEYWORDS transmembrane 7 21.875 0.8475748913014625 OLFR869, GRIN2D, SLC22A7, 1700093K21RIK, AI118078, GM364, ATP7B 28 5237 17854 0.8523009356501815 1.0 0.9997116555755853 99.99999977168666 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 7 21.875 0.849940152529146 OLFR869, GRIN2D, SLC22A7, 1700093K21RIK, AI118078, GM364, ATP7B 17 5914 12504 0.8705961924844337 1.0 0.9999999999107873 99.99999948025508 UP_SEQ_FEATURE transmembrane region 5 15.625 0.9159350176788144 GRIN2D, SLC22A7, 1700093K21RIK, AI118078, ATP7B 26 4113 16021 0.7490789055340478 1.0 1.0 99.99999999992578 SP_PIR_KEYWORDS membrane 6 18.75 0.9510268317898225 RAB31, GRIN2D, SLC22A7, 1700093K21RIK, AI118078, ATP7B 28 5507 17854 0.6947261926379412 1.0 0.9999863814628606 99.99999999999861