Annotation Cluster 1 Enrichment Score: 2.268595014131266 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006350~transcription 76 12.418300653594772 7.689366985889906E-5 GM98, E2F3, LMO3, DEDD, NFKB1, RORB, ZKSCAN5, CNOT4, ZFP472, ZFP235, MBD3L1, A130010J15RIK, ZFP553, RARG, RAX, POLR1E, A530054K11RIK, RCOR1, YY1, ARNTL, HLTF, ZFP28, PURB, MXD3, NRIP1, CCNL2, MED19, ZFP82, VGLL1, ZFP263, LCOR, TBX19, ASCL3, ZFP418, GPBP1L1, CDC73, 8430426H19RIK, ZFP318, ZFP617, ARNT, ERCC8, CHD9, ZSCAN20, ZFP119, SNF8, NFAT5, PBRM1, RQCD1, TAF9, 9630025I21RIK, ETV4, HELLS, ZFP53, ESRRA, TRIP4, ZFP449, WHSC1, POLR3A, FOXP2, MEF2D, FOXI2, IRF5, ZFP770, DR1, ZFP282, RNF2, HEYL, SUPT16H, ATP6V0A1, TCEB3, SETD8, ZIK1, B230315N10RIK, ZBTB3, RSC1A1, NFIB 375 1772 13588 1.5540827689992476 0.11126788762321049 0.11126788762321049 0.1280308811613784 SP_PIR_KEYWORDS Transcription 76 12.418300653594772 1.9558724085856494E-4 GM98, E2F3, LMO3, DEDD, YLPM1, NFKB1, RORB, ZKSCAN5, CNOT4, ZFP472, ZFP235, MBD3L1, A130010J15RIK, ZFP553, RARG, RAX, POLR1E, A530054K11RIK, RCOR1, YY1, ARNTL, HLTF, ZFP28, PURB, MXD3, NRIP1, CCNL2, MED19, ZFP82, VGLL1, ZFP263, LCOR, TBX19, ASCL3, ZFP418, GPBP1L1, CDC73, 8430426H19RIK, ZFP318, ZFP617, ARNT, ERCC8, CHD9, ZSCAN20, ZFP119, SNF8, NFAT5, PBRM1, RQCD1, TAF9, 9630025I21RIK, ETV4, HELLS, ZFP53, ESRRA, TRIP4, ZFP449, WHSC1, POLR3A, FOXP2, MEF2D, FOXI2, IRF5, ZFP770, DR1, ZFP282, RNF2, HEYL, SUPT16H, TCEB3, SETD8, ZIK1, B230315N10RIK, ZBTB3, RSC1A1, NFIB 503 1769 17854 1.524941925608587 0.06085899402722572 0.030907122112243446 0.2637363135620352 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 62 10.130718954248366 6.322500019070974E-4 GM98, E2F3, SNIP1, NFKB1, RORB, NFXL1, ZKSCAN5, ZFP472, RNF141, PATZ1, ZFP235, MBD3L1, A130010J15RIK, RARG, RAX, A530054K11RIK, YY1, ARNTL, HLTF, ZFP28, PURB, NRIP1, MED19, ZFP82, ZFP263, LCOR, TBX19, KCNH5, ASCL3, ZFP418, NUFIP1, 8430426H19RIK, ZFP617, ARNT, TRIM66, TSC22D2, ZSCAN20, ZFP119, SNF8, NFAT5, MLLT1, TAF9, 9630025I21RIK, ETV4, HELLS, ZFP53, ESRRA, RFX5, ZFP449, SIRT5, FOXP2, MEF2D, FOXI2, UPF3B, IRF5, ZFP282, RNF2, HEYL, TCEB3, ZIK1, B230315N10RIK, NFIB 375 1465 13588 1.533480773606371 0.6209845209256237 0.2763104263959093 1.0481555416181787 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 62 10.130718954248366 9.143174946944384E-4 GM98, E2F3, SNIP1, NFKB1, RORB, NFXL1, ZKSCAN5, ZFP472, RNF141, PATZ1, ZFP235, MBD3L1, A130010J15RIK, RARG, RAX, A530054K11RIK, YY1, ARNTL, HLTF, ZFP28, PURB, NRIP1, MED19, ZFP82, ZFP263, LCOR, TBX19, KCNH5, ASCL3, ZFP418, NUFIP1, 8430426H19RIK, ZFP617, ARNT, TRIM66, TSC22D2, ZSCAN20, ZFP119, SNF8, NFAT5, MLLT1, TAF9, 9630025I21RIK, ETV4, HELLS, ZFP53, ESRRA, RFX5, ZFP449, SIRT5, FOXP2, MEF2D, FOXI2, UPF3B, IRF5, ZFP282, RNF2, HEYL, TCEB3, ZIK1, B230315N10RIK, NFIB 375 1488 13588 1.5097777777777779 0.7541920212213788 0.29587624891560593 1.5124330737921965 GOTERM_BP_FAT GO:0045449~regulation of transcription 85 13.88888888888889 0.0012179891392145657 GM98, E2F3, LMO3, DEDD, SNIP1, NFKB1, RORB, NFXL1, ZKSCAN5, CNOT4, ZFP472, RNF141, PATZ1, ZFP235, MBD3L1, A130010J15RIK, ZFP553, RARG, RAX, A530054K11RIK, RCOR1, YY1, ARNTL, ZFP28, HLTF, PURB, MXD3, NRIP1, CCNL2, MED19, ZFP82, VGLL1, ZFP263, LCOR, TBX19, ASCL3, KCNH5, ZFP418, GPBP1L1, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, ARNT, ERCC8, CHD9, TRIM66, TSC22D2, ZSCAN20, ZFP119, SNF8, NFAT5, PBRM1, MLLT1, RQCD1, TAF9, 9630025I21RIK, ETV4, HELLS, ZFP53, ESRRA, TRIP4, RFX5, ZFP449, SIRT5, WHSC1, FOXP2, MEF2D, FOXI2, UPF3B, IRF5, ZFP770, DR1, RNF2, ZFP282, HEYL, SUPT16H, TCEB3, SETD8, ZIK1, ZBTB3, B230315N10RIK, APBB2, RSC1A1, NFIB 375 2227 13588 1.3830025445292622 0.8458045163104091 0.31195898044999293 2.009981339563305 SP_PIR_KEYWORDS transcription regulation 61 9.967320261437909 0.006585951418620528 GM98, E2F3, LMO3, DEDD, YLPM1, NFKB1, RORB, ZKSCAN5, CNOT4, MBD3L1, A130010J15RIK, ZFP553, RARG, RAX, RCOR1, YY1, ARNTL, ZFP28, PURB, MXD3, NRIP1, CCNL2, MED19, ZFP82, VGLL1, ZFP263, LCOR, TBX19, ASCL3, GPBP1L1, ZFP318, ARNT, ERCC8, CHD9, ZSCAN20, SNF8, NFAT5, RQCD1, PBRM1, TAF9, ETV4, HELLS, ESRRA, TRIP4, ZFP449, WHSC1, FOXP2, MEF2D, FOXI2, ZFP770, IRF5, DR1, RNF2, HEYL, SUPT16H, TCEB3, SETD8, ZIK1, ZBTB3, RSC1A1, NFIB 503 1546 17854 1.4005154069116992 0.8800982679855132 0.26140963714933774 8.534639375628162 GOTERM_MF_FAT GO:0003677~DNA binding 65 10.620915032679738 0.015350960242841605 GM98, E2F3, HMGN3, DEDD, NFKB1, RORB, POT1B, NFXL1, ZKSCAN5, FANCM, RNF141, SLK, PATZ1, A130010J15RIK, ZFP553, RARG, RAX, POLR1E, RCOR1, YY1, ARNTL, HLTF, ZFP28, PURB, MXD3, ZFP82, ZFP263, RAD18, LCOR, TBX19, ASCL3, GPBP1L1, 4930547N16RIK, ARNT, CHD9, TSC22D2, ZSCAN20, NFAT5, PBRM1, TAF9, THAP2, WDHD1, ETV4, HELLS, TRPC2, ESRRA, RFX5, ZFP449, WHSC1, POLR3A, WRN, FOXP2, PEO1, MEF2D, FOXI2, UPF3B, ZFP770, IRF5, DR1, HEYL, TCEB3, ZIK1, ZBTB3, PARP2, NFIB 368 1781 13288 1.3178356077435736 0.9995490089421969 0.8542723428969351 19.960423573747278 SP_PIR_KEYWORDS nucleus 124 20.26143790849673 0.046187647041523214 HMGN3, RNMT, SNIP1, RORB, CNOT4, ZFP472, INTS7, DHX33, TLK2, MBD3L1, MCM3AP, A130010J15RIK, KRR1, RARG, TNIK, YY1, RCOR1, ARNTL, STK3, MED19, ZFP82, DCLRE1A, ZFP263, VGLL1, RAD18, NUP43, ASCL3, GPBP1L1, NEK1, 2610029G23RIK, ZFP259, CHEK1, ZFP617, ARNT, TRIM65, VRK1, TRIM66, SNF8, PBRM1, TAF9, WDHD1, HELLS, GINS1, ESRRA, TRIP4, SMG7, TREX2, ZFP449, WHSC1, WRN, SMEK1, FOXP2, FOXI2, UPF3B, ZFP770, RNF2, SUPT16H, ZIK1, B230315N10RIK, PARP2, RSC1A1, GM98, E2F3, DEDD, YLPM1, SHOC2, NFKB1, ZKSCAN5, 2310008H09RIK, FANCM, BLZF1, RANBP3, ZFP235, CIRH1A, FANCB, FANCC, RAX, ZFP553, POLR1E, A530054K11RIK, VEZT, ZFP28, HLTF, PRPF4, PURB, MXD3, KLHDC2, CCNL2, NRIP1, NUP107, LCOR, TBX19, ZFP418, NUP160, FKBP5, 4930547N16RIK, NUFIP1, CDC73, ABI1, 8430426H19RIK, ZFP318, ERCC8, CHD9, ZFP119, ZSCAN20, NFAT5, RQCD1, 9630025I21RIK, ETV4, C80913, ZFP53, SMC5, SMC6, MTL5, MEF2D, IRF5, PPP1R7, DR1, ZFP282, HEYL, TCEB3, SETD8, ZBTB3, NFIB 503 3808 17854 1.155825550896303 0.9999997443742376 0.717750150914383 47.187975923898506 GOTERM_MF_FAT GO:0003700~transcription factor activity 29 4.738562091503268 0.08805717313714168 GM98, E2F3, RORB, NFKB1, NFXL1, ZKSCAN5, ARNT, TSC22D2, ZSCAN20, NFAT5, ETV4, A130010J15RIK, ESRRA, RARG, RAX, YY1, ZFP449, ARNTL, PURB, FOXP2, MEF2D, FOXI2, UPF3B, IRF5, HEYL, ZFP263, LCOR, TBX19, NFIB 368 776 13288 1.349422904527118 1.0 0.9707280547841766 73.46360894187525 GOTERM_MF_FAT GO:0030528~transcription regulator activity 41 6.699346405228758 0.12881979292967025 GM98, E2F3, NFKB1, RORB, NFXL1, ZKSCAN5, ARNT, TRIM66, TSC22D2, ZSCAN20, NFAT5, PATZ1, ETV4, A130010J15RIK, ESRRA, TRIP4, RARG, RAX, YY1, ZFP449, ARNTL, HLTF, PURB, MXD3, NRIP1, FOXP2, MED19, MEF2D, FOXI2, UPF3B, IRF5, RNF2, HEYL, ZFP263, VGLL1, ATP6V0A1, TCEB3, LCOR, TBX19, ASCL3, NFIB 368 1206 13288 1.2275758886725792 1.0 0.9495096947478877 86.2590623572324 SP_PIR_KEYWORDS dna-binding 46 7.516339869281046 0.19795533320213743 GM98, E2F3, HMGN3, GPBP1L1, DEDD, 4930547N16RIK, NFKB1, RORB, ZKSCAN5, ARNT, FANCM, CHD9, NFAT5, PBRM1, THAP2, WDHD1, ETV4, ESRRA, ZFP553, RARG, RAX, YY1, WHSC1, ARNTL, WRN, ZFP28, HLTF, PURB, MXD3, FOXP2, ZFP82, MEF2D, FOXI2, UPF3B, ZFP770, IRF5, DR1, HEYL, RAD18, ZIK1, ZBTB3, LCOR, PARP2, TBX19, NFIB, ASCL3 503 1404 17854 1.162942572485316 1.0 0.8981428565896357 94.91136156101477 Annotation Cluster 2 Enrichment Score: 2.015827371126246 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006259~DNA metabolic process 25 4.084967320261438 6.271793619671441E-4 CHEK1, POT1B, FANCM, ERCC8, SLK, HELLS, FANCB, FANCC, GINS1, TRPC2, SMC5, TREX2, CIDEA, SMC6, WRN, DNASE2A, PURB, PEO1, DCLRE1A, HELB, L1MD-TF30, SUPT16H, RAD18, PARP2, NFIB 375 421 13588 2.1517022961203485 0.6180230337413832 0.38195714852559237 1.0397905751858283 GOTERM_BP_FAT GO:0006974~response to DNA damage stimulus 18 2.941176470588235 0.0025396711794838807 TRPC2, NEK1, TREX2, SMC5, SMC6, CHEK1, POT1B, WRN, FANCM, ERCC8, DCLRE1A, SLK, SUPT16H, RAD18, TLK2, PARP2, FANCB, FANCC 375 287 13588 2.272557491289199 0.9797744996547234 0.47802478839066254 4.14808872105178 GOTERM_BP_FAT GO:0006281~DNA repair 15 2.450980392156863 0.0033946804669736513 TRPC2, TREX2, SMC5, SMC6, CHEK1, WRN, FANCM, ERCC8, DCLRE1A, SLK, SUPT16H, RAD18, PARP2, FANCB, FANCC 375 222 13588 2.448288288288288 0.9945726195752027 0.5253537678403877 5.507807388708141 SP_PIR_KEYWORDS DNA damage 11 1.7973856209150325 0.047975944347500035 FANCM, DCLRE1A, SMC5, TREX2, SUPT16H, SMC6, RAD18, CHEK1, TLK2, FANCB, FANCC 503 194 17854 2.0126047836691194 0.9999998600467341 0.7029921514023177 48.5092325969734 GOTERM_BP_FAT GO:0033554~cellular response to stress 18 2.941176470588235 0.05529983000302636 TRPC2, NEK1, TREX2, SMC5, SMC6, CHEK1, POT1B, WRN, FANCM, ERCC8, DCLRE1A, SLK, SUPT16H, RAD18, TLK2, PARP2, FANCB, FANCC 375 404 13588 1.6144158415841583 1.0 0.9957213020654728 61.2396338054841 SP_PIR_KEYWORDS dna repair 10 1.6339869281045754 0.05601705772916228 FANCM, DCLRE1A, SMC5, TREX2, SUPT16H, SMC6, RAD18, CHEK1, FANCB, FANCC 503 173 17854 2.0517358278077205 0.999999990806284 0.7087722605931686 54.08068925656344 Annotation Cluster 3 Enrichment Score: 1.7970757858859145 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00355:ZnF_C2H2 30 4.901960784313726 0.011418127410646685 ZFP418, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, ZKSCAN5, ZFP472, ZSCAN20, ZFP119, ZFP295, ZFP646, PATZ1, ZFP235, 9630025I21RIK, ZFP53, ZFP553, A530054K11RIK, YY1, ZFP449, ZFP28, FOXP2, ZFP82, ZFP770, ZFP282, ZFP263, RNF138, ZIK1, ZBTB3, B230315N10RIK, ZFP420 253 676 9131 1.6016675632060247 0.8934716221975589 0.4286972317706529 13.354131224803002 SMART SM00349:KRAB 16 2.6143790849673203 0.014775035031348601 ZFP53, ZFP418, A530054K11RIK, ZFP28, 8430426H19RIK, ZKSCAN5, ZFP617, ZFP82, ZFP472, ZFP119, ZFP282, ZFP263, ZIK1, ZFP235, B230315N10RIK, 9630025I21RIK 253 291 9131 1.9843798812870976 0.9451212046238444 0.4403958662188936 16.955851778595687 INTERPRO IPR015880:Zinc finger, C2H2-like 30 4.901960784313726 0.016296653541278253 ZFP418, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, ZKSCAN5, ZFP472, ZSCAN20, ZFP119, ZFP295, ZFP646, PATZ1, ZFP235, 9630025I21RIK, ZFP53, ZFP553, A530054K11RIK, YY1, ZFP449, ZFP28, FOXP2, ZFP82, ZFP770, ZFP282, ZFP263, RNF138, ZIK1, ZBTB3, B230315N10RIK, ZFP420 500 676 17763 1.5765976331360947 0.9999990964877438 0.717811403896911 22.43906364738859 INTERPRO IPR007087:Zinc finger, C2H2-type 30 4.901960784313726 0.017202839857624233 ZFP418, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, ZKSCAN5, ZFP472, ZSCAN20, ZFP119, ZFP295, ZFP646, CFH, PATZ1, ZFP235, 9630025I21RIK, ZFP53, ZFP553, A530054K11RIK, YY1, ZFP449, ZFP28, FOXP2, ZFP82, ZFP770, ZFP282, ZFP263, ZIK1, ZBTB3, B230315N10RIK, ZFP420 500 681 17763 1.565022026431718 0.9999995860791765 0.706183325057489 23.53670157791028 INTERPRO IPR001909:Krueppel-associated box 16 2.6143790849673203 0.01797981627138654 ZFP53, ZFP418, A530054K11RIK, ZFP28, 8430426H19RIK, ZKSCAN5, ZFP617, ZFP82, ZFP472, ZFP119, ZFP282, ZFP263, ZIK1, ZFP235, B230315N10RIK, 9630025I21RIK 500 291 17763 1.9533195876288663 0.9999997881684218 0.6933699813928287 24.466244315465914 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 24 3.9215686274509802 0.019406090475004176 ZFP418, ZFP53, ZFP553, A530054K11RIK, YY1, ZFP449, 8430426H19RIK, ZFP28, ZFP617, ZKSCAN5, ZFP82, ZFP472, ZFP770, ZFP282, ZFP119, ZSCAN20, ZFP646, ZFP263, ZIK1, PATZ1, ZFP235, B230315N10RIK, 9630025I21RIK, ZFP420 500 514 17763 1.6588015564202336 0.9999999381492156 0.6944402918681273 26.145130926181626 Annotation Cluster 4 Enrichment Score: 1.7285646154289895 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS helicase 12 1.9607843137254901 5.723629725763206E-4 FANCM, CHD9, PEO1, HELB, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS, HFM1 503 120 17854 3.549502982107356 0.16788207711542236 0.05942169172737444 0.7699787393878221 GOTERM_MF_FAT GO:0004386~helicase activity 12 1.9607843137254901 8.894830123577988E-4 FANCM, CHD9, PEO1, HELB, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS, HFM1 368 129 13288 3.358948432760364 0.35799530413053227 0.35799530413053227 1.2725737372083157 SMART SM00490:HELICc 9 1.4705882352941175 0.00592999867601887 FANCM, CHD9, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 253 99 9131 3.2809917355371905 0.6864485861752027 0.4400433821939441 7.154978010432245 INTERPRO IPR014021:Helicase, superfamily 1 and 2, ATP-binding 9 1.4705882352941175 0.006738772862953206 FANCM, CHD9, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 500 99 17763 3.2296363636363634 0.996743359172673 0.6149991894298669 9.92871859114114 INTERPRO IPR001650:DNA/RNA helicase, C-terminal 9 1.4705882352941175 0.007150169924043001 FANCM, CHD9, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 500 100 17763 3.1973399999999996 0.9977071257046242 0.5803265803866279 10.503943192656129 SMART SM00487:DEXDc 9 1.4705882352941175 0.007498466904588049 FANCM, CHD9, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 253 103 9131 3.153574580759047 0.7695475525551801 0.3869059402860693 8.967031817562498 INTERPRO IPR014001:DEAD-like helicase, N-terminal 9 1.4705882352941175 0.008498419131694778 FANCM, CHD9, DHX37, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 500 103 17763 3.1042135922330094 0.9992746976114893 0.5521126570046477 12.36510469515939 UP_SEQ_FEATURE domain:Helicase C-terminal 8 1.3071895424836601 0.009711603766452826 FANCM, CHD9, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 444 86 16021 3.3565891472868215 0.9999951564975975 0.9530873593088973 14.669297356712118 UP_SEQ_FEATURE domain:Helicase ATP-binding 8 1.3071895424836601 0.011612329263830821 FANCM, CHD9, DICER1, DHX33, WRN, HLTF, DDX4, HELLS 444 89 16021 3.243445692883895 0.9999995646300683 0.94657165934605 17.292968112291483 UP_SEQ_FEATURE short sequence motif:DEAH box 5 0.8169934640522877 0.012516563411885203 FANCM, CHD9, DHX33, WRN, HELLS 444 33 16021 5.467171717171717 0.9999998618362831 0.928099429767602 18.51437683327204 GOTERM_MF_FAT GO:0008026~ATP-dependent helicase activity 7 1.1437908496732025 0.03158133946308313 FANCM, HELB, DICER1, DHX33, WRN, DDX4, HFM1 368 86 13288 2.9390798786653187 0.9999998853303851 0.8643464872609379 36.98895758038954 GOTERM_MF_FAT GO:0070035~purine NTP-dependent helicase activity 7 1.1437908496732025 0.03158133946308313 FANCM, HELB, DICER1, DHX33, WRN, DDX4, HFM1 368 86 13288 2.9390798786653187 0.9999998853303851 0.8643464872609379 36.98895758038954 INTERPRO IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal 5 0.8169934640522877 0.06839585973533854 FANCM, DICER1, WRN, DDX4, HFM1 500 55 17763 3.229636363636364 1.0 0.950231997250893 66.56823035426447 INTERPRO IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 3 0.49019607843137253 0.20574929810127524 FANCM, DHX33, WRN 500 30 17763 3.5526 1.0 0.9955718245882371 97.1631908134001 INTERPRO IPR000330:SNF2-related 3 0.49019607843137253 0.2161174949168273 CHD9, HLTF, HELLS 500 31 17763 3.438 1.0 0.9949493412109871 97.68486567886552 GOTERM_MF_FAT GO:0016887~ATPase activity 11 1.7973856209150325 0.2492294347607723 FANCM, HELB, ATP2A1, DICER1, DHX33, WRN, HLTF, DDX4, ABCA3, HFM1, ABCA12 368 281 13288 1.413507658981897 1.0 0.9692483520189915 98.38466420369637 GOTERM_MF_FAT GO:0042623~ATPase activity, coupled 8 1.3071895424836601 0.416021735458909 FANCM, HELB, ATP2A1, DICER1, DHX33, WRN, DDX4, HFM1 368 223 13288 1.2953792162214854 1.0 0.9857629044422375 99.95655788174027 Annotation Cluster 5 Enrichment Score: 1.6614437150930468 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 45 7.352941176470589 0.004417363982740787 E2F3, ACADSB, DEDD, 2610029G23RIK, YLPM1, NUFIP1, CHEK1, HADHA, 2310008H09RIK, ARNT, ERCC8, BLZF1, IVD, INTS7, SNF8, DHX33, MRPL38, TAF9, CIRH1A, WDHD1, PDHX, KRR1, PDK2, RARG, POLR1E, ACADS, YY1, BCKDHB, SIRT5, ARNTL, WRN, PRPF4, NRIP1, CCNL2, MED19, PEO1, PPM1K, RNF2, HEYL, FKBP14, ATP6V0A1, TCEB3, CARS2, PARP2, ASCL3 326 1133 12504 1.5234000617287293 0.7585553308594082 0.5086298043830988 5.801898884849022 GOTERM_CC_FAT GO:0043233~organelle lumen 45 7.352941176470589 0.0047146443657770255 E2F3, ACADSB, DEDD, 2610029G23RIK, YLPM1, NUFIP1, CHEK1, HADHA, 2310008H09RIK, ARNT, ERCC8, BLZF1, IVD, INTS7, SNF8, DHX33, MRPL38, TAF9, CIRH1A, WDHD1, PDHX, KRR1, PDK2, RARG, POLR1E, ACADS, YY1, BCKDHB, SIRT5, ARNTL, WRN, PRPF4, NRIP1, CCNL2, MED19, PEO1, PPM1K, RNF2, HEYL, FKBP14, ATP6V0A1, TCEB3, CARS2, PARP2, ASCL3 326 1136 12504 1.5193769981854317 0.7806265319020992 0.3968925400572406 6.180935327399062 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 45 7.352941176470589 0.008363777157134633 E2F3, ACADSB, DEDD, 2610029G23RIK, YLPM1, NUFIP1, CHEK1, HADHA, 2310008H09RIK, ARNT, ERCC8, BLZF1, IVD, INTS7, SNF8, DHX33, MRPL38, TAF9, CIRH1A, WDHD1, PDHX, KRR1, PDK2, RARG, POLR1E, ACADS, YY1, BCKDHB, SIRT5, ARNTL, WRN, PRPF4, NRIP1, CCNL2, MED19, PEO1, PPM1K, RNF2, HEYL, FKBP14, ATP6V0A1, TCEB3, CARS2, PARP2, ASCL3 326 1174 12504 1.4701978449221895 0.9325293698392476 0.49034218076863223 10.720004670628835 GOTERM_CC_FAT GO:0005654~nucleoplasm 23 3.758169934640523 0.06517246142180842 E2F3, RARG, YY1, YLPM1, NUFIP1, CHEK1, ARNTL, WRN, PRPF4, NRIP1, CCNL2, ARNT, MED19, RNF2, INTS7, SNF8, HEYL, ATP6V0A1, TCEB3, TAF9, WDHD1, PARP2, ASCL3 326 599 12504 1.4727613507174535 0.9999999995974584 0.8351581197598787 59.742100506805265 GOTERM_CC_FAT GO:0031981~nuclear lumen 31 5.065359477124183 0.07856936768153083 E2F3, DEDD, 2610029G23RIK, YLPM1, NUFIP1, CHEK1, 2310008H09RIK, ARNT, ERCC8, INTS7, SNF8, DHX33, TAF9, CIRH1A, WDHD1, KRR1, RARG, POLR1E, YY1, ARNTL, WRN, PRPF4, NRIP1, CCNL2, MED19, RNF2, HEYL, ATP6V0A1, TCEB3, PARP2, ASCL3 326 883 12504 1.346580605715318 0.999999999996087 0.8264196243756571 66.87038020094745 GOTERM_CC_FAT GO:0044451~nucleoplasm part 19 3.104575163398693 0.12050518956790734 E2F3, RARG, YY1, YLPM1, NUFIP1, ARNTL, PRPF4, NRIP1, ARNT, CCNL2, MED19, RNF2, INTS7, HEYL, SNF8, ATP6V0A1, TCEB3, TAF9, ASCL3 326 513 12504 1.4205862304021812 1.0 0.8595357289717905 82.33541795104682 Annotation Cluster 6 Enrichment Score: 1.500125002186707 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS guanine-nucleotide releasing factor 8 1.3071895424836601 0.024969285475710465 ARHGEF3, ABR, RPGR, DOCK8, DOCK5, DOCK6, ARHGEF10, BCAR3 503 102 17854 2.783923907535181 0.9997015488695954 0.5941932677879238 28.921548084449878 UP_SEQ_FEATURE domain:DHR-1 3 0.49019607843137253 0.03557209466274949 DOCK8, DOCK5, DOCK6 444 11 16021 9.840909090909092 1.0 0.9839026808399581 44.498905967019965 UP_SEQ_FEATURE domain:DHR-2 3 0.49019607843137253 0.03557209466274949 DOCK8, DOCK5, DOCK6 444 11 16021 9.840909090909092 1.0 0.9839026808399581 44.498905967019965 Annotation Cluster 7 Enrichment Score: 1.4676301742521847 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04130:SNARE interactions in vesicular transport 5 0.8169934640522877 0.013174799675293409 STX3, STX16, GOSR2, VAMP2, VTI1A 141 38 5738 5.3546099290780145 0.7852827943455223 0.5366241205517084 14.041705758437129 SMART SM00397:t_SNARE 4 0.6535947712418301 0.030525278141280802 STX3, STX16, ABI1, VTI1A 253 25 9131 5.774545454545454 0.9976307248479847 0.6348797529229422 32.08767261659944 INTERPRO IPR000727:Target SNARE coiled-coil region 4 0.6535947712418301 0.03204426436953725 STX3, STX16, ABI1, VTI1A 500 25 17763 5.68416 0.9999999999989538 0.802634623243522 39.56990843522321 UP_SEQ_FEATURE domain:t-SNARE coiled-coil homology 3 0.49019607843137253 0.10455031524094008 STX3, STX16, ABI1 444 20 16021 5.4125000000000005 1.0 0.999316531660435 83.38812207715722 Annotation Cluster 8 Enrichment Score: 1.4533841193135895 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008270~zinc ion binding 80 13.071895424836603 0.0021939552318597797 PDLIM7, LMO3, RORB, NFXL1, ZNRF1, MOBKL2C, ZKSCAN5, CNOT4, ZFP472, RNF141, ADAM2, ZFP646, PATZ1, ZFP235, ZFYVE1, ZDHHC3, ZFP553, RARG, A530054K11RIK, YY1, ZFP28, HLTF, RNF170, ZSWIM5, ZFP82, ZFYVE28, ZFP263, RNF138, RAD18, TRIM39, ZNHIT3, ZFP420, ZFP418, ZFP259, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, TRIM65, TRIM66, ZDHHC21, ZFP295, ZFP119, DGKG, ZSCAN20, CDADC1, RNF113A1, ADAM33, ANKIB1, ADAM30, RNF113A2, THAP2, 9630025I21RIK, RASA2, RBM26, DCTD, COL18A1, ZFP53, ZC3H13, ESRRA, TRIP4, CBL, BMX, ZFP449, SIRT5, WHSC1, POLR3A, 4930555K19RIK, FOXP2, MSRB3, UPF3B, ZFP770, RNF2, ZFP282, PHF16, CARS2, ZIK1, ZBTB3, B230315N10RIK, GPATCH8 368 2105 13288 1.3723019725291747 0.6650553577558644 0.4212559786536577 3.1116354089390175 SP_PIR_KEYWORDS zinc 73 11.928104575163399 0.004444835423603841 PDLIM7, LMO3, RORB, ZNRF1, MOBKL2C, ZKSCAN5, CNOT4, ZFP472, RNF141, PATZ1, ZFP235, ZFYVE1, ZDHHC3, ZFP553, RARG, A530054K11RIK, YY1, HLTF, ZFP28, RNF170, ZSWIM5, ZFP82, ZFYVE28, ZFP263, RNF138, RAD18, TRIM39, ZNHIT3, ZFP418, ZFP259, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, TRIM65, TRIM66, ZDHHC21, ZFP295, DGKG, ZSCAN20, ZFP119, CDADC1, RNF113A1, ADAM33, ANKIB1, RNF113A2, THAP2, 9630025I21RIK, RASA2, RBM26, DCTD, COL18A1, ZFP53, ZC3H13, ESRRA, TRIP4, CBL, BMX, ZFP449, SIRT5, WHSC1, 4930555K19RIK, FOXP2, MSRB3, ZFP770, RNF2, ZFP282, PHF16, CARS2, ZIK1, ZBTB3, B230315N10RIK, GPATCH8 503 1886 17854 1.3738797332653072 0.7606845030776106 0.21205639146842303 5.836984705185255 SP_PIR_KEYWORDS zinc-finger 48 7.8431372549019605 0.014076135524573478 ZFP259, NUFIP1, RORB, ZNRF1, ZFP318, ZKSCAN5, CNOT4, TRIM65, TRIM66, RNF141, ZDHHC21, ZSCAN20, DGKG, RNF113A1, ANKIB1, RNF113A2, THAP2, ZFYVE1, RASA2, RBM26, ZFP53, ESRRA, ZDHHC3, ZFP553, TRIP4, RARG, YY1, CBL, BMX, WHSC1, 4930555K19RIK, ZFP28, HLTF, RNF170, FOXP2, ZSWIM5, ZFP82, ZFP770, PHF16, RNF2, ZFYVE28, RNF138, RAD18, ZIK1, ZBTB3, GPATCH8, TRIM39, ZNHIT3 503 1204 17854 1.4150842453584145 0.9894385235741852 0.43380558744576114 17.418922563934025 GOTERM_MF_FAT GO:0046914~transition metal ion binding 89 14.54248366013072 0.021450697462287085 PDLIM7, LMO3, DICER1, RORB, 4833423E24RIK, ZNRF1, NFXL1, MOBKL2C, ZKSCAN5, CNOT4, ZFP472, RNF141, ADAM2, ZFP646, PATZ1, ZFP235, ZFYVE1, ZDHHC3, ZFP553, RARG, A530054K11RIK, YY1, GALNTL2, ZFP28, HLTF, RNF170, ZSWIM5, ZFP82, PPM1D, EIF2AK1, PPM1K, ZFYVE28, ZFP263, RNF138, RAD18, STEAP2, TRIM39, ZFP420, ZNHIT3, ZFP418, AHCY, ZFP259, NUFIP1, 8430426H19RIK, ZFP318, ZFP617, TRIM65, TRIM66, ZDHHC21, ZFP295, ZFP119, DGKG, ZSCAN20, CDADC1, RNF113A1, ADAM33, ANKIB1, ADAM30, RNF113A2, THAP2, 9630025I21RIK, RASA2, RBM26, DCTD, CYP2G1, COL18A1, ZFP53, ZC3H13, ESRRA, TRIP4, CBL, BMX, ZFP449, SIRT5, WHSC1, POLR3A, 4930555K19RIK, FOXP2, MSRB3, UPF3B, ZFP770, RNF2, ZFP282, PHF16, CARS2, ZIK1, ZBTB3, B230315N10RIK, GPATCH8 368 2608 13288 1.2322369298479594 0.9999795736653607 0.8346648956722605 26.808008778115088 SP_PIR_KEYWORDS metal-binding 90 14.705882352941178 0.05089490725609026 SYT1, PDLIM7, LMO3, OVCH2, DICER1, PDE11A, RORB, 4833423E24RIK, ZNRF1, MOBKL2C, ZKSCAN5, CNOT4, ZFP472, RNF141, PATZ1, ZFP235, ENOPH1, ZFYVE1, ZDHHC3, ZFP553, RARG, A530054K11RIK, YY1, ZFP28, HLTF, STK3, RNF170, NME6, ZSWIM5, ZFP82, PPM1D, PPM1K, ZFYVE28, ZFP263, RNF138, RAD18, STEAP2, TRIM39, ZNHIT3, ZFP418, NEK1, ZFP259, NUFIP1, 8430426H19RIK, ZFP318, PDSS1, ZFP617, TRIM65, TRIM66, ZDHHC21, GNPTAB, ZFP295, ZFP119, DGKG, ZSCAN20, CDADC1, RNF113A1, ANKIB1, ADAM33, ADAM30, RNF113A2, THAP2, 9630025I21RIK, RASA2, RBM26, DCTD, CYP2G1, COL18A1, ZFP53, ZC3H13, ESRRA, TRIP4, CBL, BMX, ZFP449, SIRT5, WHSC1, 4930555K19RIK, FOXP2, MSRB3, ZFP770, RNF2, ZFP282, PHF16, ATP2A1, CARS2, ZIK1, ZBTB3, B230315N10RIK, GPATCH8 503 2682 17854 1.191108383257502 0.9999999477734298 0.6981095371326984 50.60028803966388 GOTERM_MF_FAT GO:0046872~metal ion binding 114 18.627450980392158 0.2347380954681979 SYT1, PDLIM7, LMO3, OVCH2, RORB, ZNRF1, NFXL1, ITSN1, MOBKL2C, CNOT4, SSR1, ZFP472, RNF141, ADAM2, PATZ1, ENOPH1, RARG, YY1, STK3, NME6, ZFP82, KCNT1, EIF2AK1, ZFP263, RNF138, RAD18, DST, TRIM39, ZNHIT3, AHCY, NEK1, ZFP259, ZFP617, TRIM65, TRIM66, FGG, CDADC1, RNF113A1, ADAM33, ANKIB1, RNF113A2, ADAM30, COL18A1, TRPC2, ZC3H13, ESRRA, TRIP4, MRC2, ITGA1, BMX, TREX2, ZFP449, WHSC1, FOXP2, UPF3B, ZFP770, RNF2, ATP2A1, ZIK1, CARS2, B230315N10RIK, GPATCH8, DICER1, PDE11A, 4833423E24RIK, ZKSCAN5, ZFP646, SLC22A5, ZFP235, ZFYVE1, ZFP553, ZDHHC3, A530054K11RIK, GALNTL2, HLTF, ZFP28, RNF170, SLIT2, ZSWIM5, PPM1D, PPM1K, ZFYVE28, FKBP14, STEAP2, KCNH5, ZFP420, ZFP418, PPP3R1, NUFIP1, 8430426H19RIK, ZFP318, ZDHHC21, GNPTAB, ZFP295, ZSCAN20, DGKG, ZFP119, PCDHB17, THAP2, 9630025I21RIK, RASA2, RBM26, CYP2G1, DCTD, ZFP53, SVEP1, CBL, SIRT5, POLR3A, 4930555K19RIK, MSRB3, PHF16, ZFP282, ZBTB3 368 3850 13288 1.069192546583851 1.0 0.9699876011646038 97.87303655862729 GOTERM_MF_FAT GO:0043167~ion binding 116 18.954248366013072 0.24762598635618352 SYT1, PDLIM7, LMO3, OVCH2, RORB, ZNRF1, NFXL1, ITSN1, MOBKL2C, CNOT4, SSR1, ZFP472, RNF141, ADAM2, PATZ1, ENOPH1, RARG, YY1, STK3, NME6, ZFP82, KCNT1, EIF2AK1, ZFP263, RNF138, RAD18, DST, TRIM39, ZNHIT3, AHCY, NEK1, ZFP259, ZFP617, TRIM65, TRIM66, FGG, CDADC1, RNF113A1, ADAM33, ANKIB1, RNF113A2, ADAM30, COL18A1, TRPC2, ZC3H13, ESRRA, TRIP4, MRC2, ITGA1, BMX, TREX2, ZFP449, WHSC1, FOXP2, UPF3B, ZFP770, RNF2, ATP2A1, ZIK1, CARS2, B230315N10RIK, GPATCH8, DICER1, GLRA2, PDE11A, 4833423E24RIK, ZKSCAN5, ZFP646, SLC22A5, ZFP235, ZFYVE1, ZFP553, ZDHHC3, A530054K11RIK, GALNTL2, HLTF, ZFP28, RNF170, SLIT2, ZSWIM5, PPM1D, PPM1K, ZFYVE28, FKBP14, STEAP2, KCNH5, ZFP420, ZFP418, CLCNKA, PPP3R1, NUFIP1, 8430426H19RIK, ZFP318, ZDHHC21, GNPTAB, ZFP295, ZSCAN20, DGKG, ZFP119, PCDHB17, THAP2, 9630025I21RIK, RASA2, RBM26, CYP2G1, DCTD, ZFP53, SVEP1, CBL, SIRT5, POLR3A, 4930555K19RIK, MSRB3, PHF16, ZFP282, ZBTB3 368 3934 13288 1.0647200548175328 1.0 0.9710531941767973 98.33429535020302 GOTERM_MF_FAT GO:0043169~cation binding 114 18.627450980392158 0.27093469266364 SYT1, PDLIM7, LMO3, OVCH2, RORB, ZNRF1, NFXL1, ITSN1, MOBKL2C, CNOT4, SSR1, ZFP472, RNF141, ADAM2, PATZ1, ENOPH1, RARG, YY1, STK3, NME6, ZFP82, KCNT1, EIF2AK1, ZFP263, RNF138, RAD18, DST, TRIM39, ZNHIT3, AHCY, NEK1, ZFP259, ZFP617, TRIM65, TRIM66, FGG, CDADC1, RNF113A1, ADAM33, ANKIB1, RNF113A2, ADAM30, COL18A1, TRPC2, ZC3H13, ESRRA, TRIP4, MRC2, ITGA1, BMX, TREX2, ZFP449, WHSC1, FOXP2, UPF3B, ZFP770, RNF2, ATP2A1, ZIK1, CARS2, B230315N10RIK, GPATCH8, DICER1, PDE11A, 4833423E24RIK, ZKSCAN5, ZFP646, SLC22A5, ZFP235, ZFYVE1, ZFP553, ZDHHC3, A530054K11RIK, GALNTL2, HLTF, ZFP28, RNF170, SLIT2, ZSWIM5, PPM1D, PPM1K, ZFYVE28, FKBP14, STEAP2, KCNH5, ZFP420, ZFP418, PPP3R1, NUFIP1, 8430426H19RIK, ZFP318, ZDHHC21, GNPTAB, ZFP295, ZSCAN20, DGKG, ZFP119, PCDHB17, THAP2, 9630025I21RIK, RASA2, RBM26, CYP2G1, DCTD, ZFP53, SVEP1, CBL, SIRT5, POLR3A, 4930555K19RIK, MSRB3, PHF16, ZFP282, ZBTB3 368 3885 13288 1.0595601812993116 1.0 0.9742579100940656 98.9410063968557 Annotation Cluster 9 Enrichment Score: 1.2714092278193783 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR006092:Acyl-CoA dehydrogenase, N-terminal 4 0.6535947712418301 0.0030726353997816156 ACADSB, ACADS, IVD, ACAD11 500 11 17763 12.918545454545455 0.9262097517503071 0.7283563947933009 4.647715828973798 UP_SEQ_FEATURE binding site:FAD; shared with dimeric partner 3 0.49019607843137253 0.004411174298445304 ACADSB, ACADS, ACAD11 444 4 16021 27.062500000000004 0.9960885574009078 0.9374584730031947 6.934184263636456 UP_SEQ_FEATURE nucleotide phosphate-binding region:FAD; shared with dimeric partner 3 0.49019607843137253 0.004411174298445304 ACADSB, ACADS, ACAD11 444 4 16021 27.062500000000004 0.9960885574009078 0.9374584730031947 6.934184263636456 INTERPRO IPR006090:Acyl-CoA oxidase/dehydrogenase, type 1 4 0.6535947712418301 0.005107740496451137 ACADSB, ACADS, IVD, ACAD11 500 13 17763 10.931076923076922 0.9869287833021071 0.7644379429299009 7.613965467899019 INTERPRO IPR013786:Acyl-CoA dehydrogenase/oxidase, N-terminal 4 0.6535947712418301 0.006366520260692371 ACADSB, ACADS, IVD, ACAD11 500 14 17763 10.150285714285713 0.9955269349630191 0.6610613911865939 9.405248203442573 INTERPRO IPR013764:Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal 4 0.6535947712418301 0.007794056938155269 ACADSB, ACADS, IVD, ACAD11 500 15 17763 9.4736 0.998676435999266 0.5632648787565407 11.397347471354703 GOTERM_MF_FAT GO:0003995~acyl-CoA dehydrogenase activity 4 0.6535947712418301 0.008955483765531763 ACADSB, ACADS, IVD, ACAD11 368 16 13288 9.027173913043478 0.9886656905711604 0.7753714148840158 12.143959438502193 INTERPRO IPR006091:Acyl-CoA oxidase/dehydrogenase, central region 4 0.6535947712418301 0.009395181838189569 ACADSB, ACADS, IVD, ACAD11 500 16 17763 8.8815 0.9996629694331894 0.5504614617384522 13.582906013610296 KEGG_PATHWAY mmu00280:Valine, leucine and isoleucine degradation 5 0.8169934640522877 0.025094206941169026 ACADSB, ACADS, IVD, BCKDHB, HADHA 141 46 5738 4.423373419673142 0.9475594157126284 0.6256976900523807 25.169821756165334 UP_SEQ_FEATURE binding site:Substrate; via amide nitrogen 4 0.6535947712418301 0.027625512191908595 ACADSB, PLB1, ACADS, ACAD11 444 24 16021 6.013888888888888 0.9999999999999994 0.9798252219406309 36.57920026763924 INTERPRO IPR006089:Acyl-CoA dehydrogenase, conserved site 3 0.49019607843137253 0.030524698496728633 ACADSB, ACADS, IVD 500 10 17763 10.6578 0.9999999999960497 0.8062288255105049 38.08599343839346 GOTERM_MF_FAT GO:0050662~coenzyme binding 10 1.6339869281045754 0.03355567456594148 ACADSB, ACADS, IVD, OGDHL, SIRT5, STEAP2, ACAD11, DHTKD1, PDHX, HADHA 368 160 13288 2.2567934782608696 0.9999999584982391 0.8487187273490691 38.81279139025909 UP_SEQ_FEATURE binding site:Substrate; via carbonyl oxygen 4 0.6535947712418301 0.03408399605739117 ACADSB, ACADS, IVD, ACAD11 444 26 16021 5.551282051282051 1.0 0.9870760291202851 43.09034649345277 GOTERM_MF_FAT GO:0048037~cofactor binding 11 1.7973856209150325 0.09608614366486362 SGPL1, ACADSB, ACADS, IVD, OGDHL, SIRT5, STEAP2, ACAD11, DHTKD1, PDHX, HADHA 368 226 13288 1.7575028857252788 1.0 0.9650523597756958 76.63492091277999 UP_SEQ_FEATURE binding site:FAD 3 0.49019607843137253 0.12268881032134835 ACADS, IVD, ACAD11 444 22 16021 4.920454545454546 1.0 0.9985920474541103 88.08894836279401 GOTERM_MF_FAT GO:0050660~FAD binding 5 0.8169934640522877 0.1327905056883007 ACADSB, ACADS, IVD, STEAP2, ACAD11 368 71 13288 2.5428658909981627 1.0 0.941462987141108 87.13344169195177 UP_SEQ_FEATURE nucleotide phosphate-binding region:FAD 4 0.6535947712418301 0.21594697024407863 ACADSB, ACADS, IVD, ACAD11 444 58 16021 2.4885057471264367 1.0 0.9994131642708028 98.08326823935695 SP_PIR_KEYWORDS Flavoprotein 5 0.8169934640522877 0.3290552589401837 ACADSB, ACADS, IVD, STEAP2, ACAD11 503 103 17854 1.7230597000521146 1.0 0.949161063159029 99.542776623696 SP_PIR_KEYWORDS FAD 5 0.8169934640522877 0.36748908513597023 ACADSB, ACADS, IVD, STEAP2, ACAD11 503 109 17854 1.628212377113466 1.0 0.9590927035482396 99.7938162253052 COG_ONTOLOGY Lipid metabolism 4 0.6535947712418301 0.6399837993100841 ACADSB, ACADS, IVD, ACAD11 78 86 2040 1.2164579606440071 0.9999999995183152 0.9992161114680809 99.96248522643789 GOTERM_MF_FAT GO:0009055~electron carrier activity 6 0.9803921568627451 0.6598692614216217 CYP2G1, ACADSB, ACADS, IVD, STEAP2, ACAD11 368 202 13288 1.0725355144210074 1.0 0.9981969993880693 99.99998183200293 UP_SEQ_FEATURE region of interest:Substrate binding 4 0.6535947712418301 0.6759264184809439 ACADSB, ACADS, IVD, ENOPH1 444 125 16021 1.1546666666666667 1.0 0.9999996528670013 99.99999888979748 SP_PIR_KEYWORDS oxidoreductase 13 2.1241830065359477 0.88448030390727 CYP2G1, ACADSB, ACADS, BCKDHB, 4833423E24RIK, HADHA, MSRB3, DIO2, IVD, STEAP2, DHTKD1, ACAD11, NSDHL 503 572 17854 0.8067052232062172 1.0 0.9979417162236962 99.99999999997786 GOTERM_BP_FAT GO:0055114~oxidation reduction 13 2.1241830065359477 0.9618581259901582 CYP2G1, ACADSB, ACADS, BCKDHB, 4833423E24RIK, HADHA, MSRB3, DIO2, IVD, STEAP2, DHTKD1, ACAD11, NSDHL 375 672 13588 0.7009682539682539 1.0 0.999999547519636 100.0 Annotation Cluster 10 Enrichment Score: 1.0938223115023076 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005759~mitochondrial matrix 12 1.9607843137254901 0.0035464284974740493 PEO1, PDK2, ACADSB, PPM1K, ACADS, IVD, BCKDHB, SIRT5, CARS2, MRPL38, PDHX, HADHA 326 163 12504 2.823741954909858 0.6803175010245719 0.6803175010245719 4.683266947314557 GOTERM_CC_FAT GO:0031980~mitochondrial lumen 12 1.9607843137254901 0.0035464284974740493 PEO1, PDK2, ACADSB, PPM1K, ACADS, IVD, BCKDHB, SIRT5, CARS2, MRPL38, PDHX, HADHA 326 163 12504 2.823741954909858 0.6803175010245719 0.6803175010245719 4.683266947314557 UP_SEQ_FEATURE transit peptide:Mitochondrion 18 2.941176470588235 0.12018137358526966 PDK2, ACADSB, ACADS, COX10, BCKDHB, SIRT5, MRRF, HADHA, MSRB3, PEO1, PPM1K, IVD, COQ10B, CARS2, MRPL38, DHTKD1, PDHX, 2410091C18RIK 444 449 16021 1.4465478841870825 1.0 0.9990705673096271 87.52334432695322 SP_PIR_KEYWORDS transit peptide 18 2.941176470588235 0.14745329783919325 PDK2, ACADSB, ACADS, COX10, BCKDHB, SIRT5, MRRF, HADHA, MSRB3, PEO1, PPM1K, IVD, COQ10B, CARS2, MRPL38, DHTKD1, PDHX, 2410091C18RIK 503 457 17854 1.3980536909832035 1.0 0.8815989261371627 88.39518149157719 GOTERM_CC_FAT GO:0044429~mitochondrial part 18 2.941176470588235 0.20542497749547528 PDK2, ACADSB, ACADS, COX10, BCKDHB, SIRT5, CIDEA, HADHA, PEO1, MTCH2, TOMM70A, PPM1K, IVD, TOMM20, CARS2, MRPL38, PDHX, ABCA12 326 524 12504 1.3175666182737789 1.0 0.9283661880634648 95.5152419272247 SP_PIR_KEYWORDS mitochondrion 22 3.594771241830065 0.6365975622783384 PDK2, ACADSB, COX10, ACADS, BCKDHB, SIRT5, MRRF, HADHA, MSRB3, PEO1, MTCH2, TOMM70A, PPM1K, IVD, TOMM20, COQ10B, CARS2, MRPL38, DHTKD1, PDHX, TRIM39, 2410091C18RIK 503 790 17854 0.9884691848906562 1.0 0.9876110721960897 99.99988388890458 GOTERM_CC_FAT GO:0005739~mitochondrion 32 5.228758169934641 0.7562258704510842 ACADSB, COX10, PDSS1, HADHA, CCDC58, MTCH2, IVD, RNASET2B, MRPL38, GUF1, DHTKD1, PDHX, ABCA12, PDK2, ACADS, BCKDHB, SECISBP2, SIRT5, CIDEA, MRRF, CECR5, MSRB3, NME6, PEO1, TOMM70A, PPM1K, TOMM20, COQ10B, CARS2, ACAD11, TRIM39, 2410091C18RIK 326 1322 12504 0.9284315454368265 1.0 0.9951585354588905 99.99999947054638 Annotation Cluster 11 Enrichment Score: 1.0593634345051537 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00184:RING 19 3.104575163398693 9.393848324030529E-4 A530054K11RIK, CBL, ZFP449, 4930555K19RIK, WHSC1, HLTF, ZNRF1, RNF170, CNOT4, TRIM65, TRIM66, RNF141, RNF2, RNF138, RNF113A1, RAD18, ANKIB1, RNF113A2, TRIM39 253 286 9131 2.3976478067387155 0.1674534431235345 0.1674534431235345 1.1662363085949923 INTERPRO IPR001841:Zinc finger, RING-type 19 3.104575163398693 0.0012708179468835265 A530054K11RIK, CBL, ZFP449, 4930555K19RIK, WHSC1, HLTF, ZNRF1, RNF170, CNOT4, TRIM65, TRIM66, RNF141, RNF2, RNF138, RNF113A1, RAD18, ANKIB1, RNF113A2, TRIM39 500 286 17763 2.360118881118881 0.6594070890197268 0.6594070890197268 1.947376737548756 INTERPRO IPR017907:Zinc finger, RING-type, conserved site 16 2.6143790849673203 0.005627629874585904 CBL, 4930555K19RIK, ZNRF1, HLTF, RNF170, CNOT4, TRIM65, TRIM66, RNF141, RNF2, RNF138, RNF113A1, RAD18, ANKIB1, RNF113A2, TRIM39 500 254 17763 2.2378582677165353 0.9916045498965028 0.6973009930366187 8.357762613500896 INTERPRO IPR018957:Zinc finger, C3HC4 RING-type 12 1.9607843137254901 0.04568652883530138 TRIM65, RNF141, RNF2, CBL, RNF138, RNF113A1, RAD18, RNF113A2, HLTF, ZNRF1, TRIM39, RNF170 500 219 17763 1.9466301369863015 1.0 0.8892480753068764 51.48017128098436 UP_SEQ_FEATURE zinc finger region:RING-type 10 1.6339869281045754 0.056080573703219665 TRIM65, RNF141, RNF2, CBL, RNF138, RAD18, 4930555K19RIK, HLTF, TRIM39, RNF170 444 176 16021 2.050189393939394 1.0 0.9943129722164972 60.865340539845334 SP_PIR_KEYWORDS ligase 13 2.1241830065359477 0.11860105524928256 CBL, TTLL4, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, 4930524E20RIK, RNF2, RAD18, RNF138, UBE2W, CARS2 503 290 17854 1.5911565092205389 1.0 0.8415043620090221 81.81204178780797 GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 21 3.431372549019608 0.23872448100603988 SMG7, CBL, CIDEA, 4930555K19RIK, HLTF, ZNRF1, DNASE2A, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, UBE2W, RNF138, FBXO44, RAD18, USP34, CLN8 375 609 13588 1.249471264367816 1.0 0.9949902863351359 98.93723016734457 SP_PIR_KEYWORDS ubl conjugation pathway 17 2.7777777777777777 0.2879814934545536 CBL, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, FBXO44, RAD18, RNF138, UBE2W, USP34 503 484 17854 1.246726254045972 1.0 0.9299973195348977 98.98020984372906 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 18 2.941176470588235 0.30389729479684235 CBL, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, FBXO44, RAD18, RNF138, UBE2W, USP34, CLN8 375 537 13588 1.2145698324022347 1.0 0.9961398093702104 99.76073814102753 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 17 2.7777777777777777 0.32561485125865214 CBL, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, FBXO44, RAD18, RNF138, UBE2W, USP34 375 508 13588 1.2125774278215224 1.0 0.9970050266216428 99.85889656935547 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 17 2.7777777777777777 0.32561485125865214 CBL, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, FBXO44, RAD18, RNF138, UBE2W, USP34 375 508 13588 1.2125774278215224 1.0 0.9970050266216428 99.85889656935547 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 21 3.431372549019608 0.3425645320448722 SMG7, CBL, CIDEA, 4930555K19RIK, HLTF, ZNRF1, DNASE2A, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, UBE2W, RNF138, FBXO44, RAD18, USP34, CLN8 375 654 13588 1.1634984709480123 1.0 0.9969607734295891 99.90766656832695 GOTERM_BP_FAT GO:0030163~protein catabolic process 18 2.941176470588235 0.364001182625433 CBL, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, FBXO44, RAD18, RNF138, UBE2W, USP34, CLN8 375 556 13588 1.173064748201439 1.0 0.9974830238016459 99.94685014799451 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 17 2.7777777777777777 0.403810652175744 CBL, 4930555K19RIK, ZNRF1, HLTF, CNOT4, TRIM65, ASB8, CUL2, 4930524E20RIK, RNF2, KLHL13, USP38, FBXO44, RAD18, RNF138, UBE2W, USP34 375 534 13588 1.153538077403246 1.0 0.9980639156979161 99.98189454219045 GOTERM_BP_FAT GO:0006508~proteolysis 29 4.738562091503268 0.5651804968384395 OVCH2, PGC, ZNRF1, CNOT4, PCSK2, TRIM65, CUL2, 4930524E20RIK, ADAM2, USP38, CFH, FBXO44, ADAM33, PREPL, ADAM30, USP34, HPN, CBL, GZME, 4930555K19RIK, HLTF, TINAG, ASB8, RNF2, KLHL13, RAD18, RNF138, UBE2W, RSC1A1 375 1034 13588 1.0162527401676338 1.0 0.999172840896183 99.9999057934898 Annotation Cluster 12 Enrichment Score: 1.0284544965988816 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046903~secretion 12 1.9607843137254901 0.04239107056909496 TRPC2, SYT1, STX3, GNPTAB, STXBP5, BLOC1S3, AGT, CLCNKA, VAMP2, STEAP2, GCGR, EXOC6B 375 221 13588 1.9674932126696834 1.0 0.9939715442620038 51.40545314358877 GOTERM_BP_FAT GO:0032940~secretion by cell 10 1.6339869281045754 0.07198734649061109 TRPC2, SYT1, STX3, GNPTAB, STXBP5, BLOC1S3, VAMP2, STEAP2, GCGR, EXOC6B 375 186 13588 1.9481003584229393 1.0 0.9878190832348827 71.19719881051614 GOTERM_BP_FAT GO:0006887~exocytosis 7 1.1437908496732025 0.0830743204059429 TRPC2, STX3, STXBP5, VAMP2, STEAP2, GCGR, EXOC6B 375 110 13588 2.3058424242424245 1.0 0.9881417988692949 76.42393255041608 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 16 2.6143790849673203 0.3035181499295576 TRPC2, STX3, MRC2, 4930555K19RIK, ITSN1, GCGR, AP1S3, BLZF1, STXBP5, STX16, SEC22A, GOSR2, VAMP2, STEAP2, ERC1, EXOC6B 375 466 13588 1.2441087267525035 1.0 0.9963195973217294 99.75855770108244 Annotation Cluster 13 Enrichment Score: 0.9062741816132563 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006865~amino acid transport 7 1.1437908496732025 0.013314685337113705 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC36A4, CLN8, SLC7A6 375 71 13588 3.572431924882629 0.9999999988249098 0.9234828292180424 20.01396315379659 GOTERM_CC_FAT GO:0031253~cell projection membrane 5 0.8169934640522877 0.024949959215202846 TRPC2, SLC1A2, SLC6A14, SLC22A5, DLG1 326 43 12504 4.459980025681267 0.999699643909736 0.6860899601385663 28.90252497258574 GOTERM_BP_FAT GO:0015837~amine transport 7 1.1437908496732025 0.04127979634041487 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC36A4, CLN8, SLC7A6 375 92 13588 2.756985507246377 1.0 0.9972019891642401 50.45734702079743 GOTERM_BP_FAT GO:0015813~L-glutamate transport 3 0.49019607843137253 0.041559424141985817 SLC1A2, SLC1A3, CLN8 375 12 13588 9.058666666666667 1.0 0.9956003617468995 50.697540808794415 GOTERM_BP_FAT GO:0015800~acidic amino acid transport 3 0.49019607843137253 0.041559424141985817 SLC1A2, SLC1A3, CLN8 375 12 13588 9.058666666666667 1.0 0.9956003617468995 50.697540808794415 GOTERM_BP_FAT GO:0046942~carboxylic acid transport 7 1.1437908496732025 0.05547723257573054 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC36A4, CLN8, SLC7A6 375 99 13588 2.5620471380471384 1.0 0.9942018904961621 61.36072175596341 GOTERM_BP_FAT GO:0015849~organic acid transport 7 1.1437908496732025 0.05771823239569128 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC36A4, CLN8, SLC7A6 375 100 13588 2.536426666666667 1.0 0.9869992611652587 62.86004154615975 GOTERM_MF_FAT GO:0005275~amine transmembrane transporter activity 5 0.8169934640522877 0.09605199740155497 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC7A6 368 63 13288 2.8657694962042783 1.0 0.9724602594026642 76.62221448542562 GOTERM_BP_FAT GO:0042493~response to drug 5 0.8169934640522877 0.2237755935582344 SLC1A2, SLC1A3, BLOC1S3, SLC35A3, HADHA 375 88 13588 2.058787878787879 1.0 0.9951221757429526 98.53058821279221 SP_PIR_KEYWORDS amino-acid transport 3 0.49019607843137253 0.2372843165509638 SLC6A14, SLC36A4, SLC7A6 503 33 17854 3.2268208928248687 1.0 0.9046289122716875 97.4189331737972 GOTERM_CC_FAT GO:0044463~cell projection part 7 1.1437908496732025 0.28119833647370357 TRPC2, PPP1R9A, SLC1A2, TTLL4, SLC6A14, SLC22A5, DLG1 326 170 12504 1.5793576326236018 1.0 0.9473460561919453 98.84094406525149 GOTERM_BP_FAT GO:0006820~anion transport 6 0.9803921568627451 0.2878260191707642 SLC1A2, SLC1A3, SLC26A5, GLRA2, CLCNKA, CLN8 375 130 13588 1.6723692307692308 1.0 0.9958346309034256 99.6500351356995 GOTERM_BP_FAT GO:0015711~organic anion transport 3 0.49019607843137253 0.29161825598256585 SLC1A2, SLC1A3, CLN8 375 39 13588 2.7872820512820513 1.0 0.9959505392428362 99.67982069996296 GOTERM_MF_FAT GO:0015293~symporter activity 6 0.9803921568627451 0.30097368759821497 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC36A4, SLC35A3 368 132 13288 1.641304347826087 1.0 0.9737247762487021 99.42203153090236 GOTERM_MF_FAT GO:0015294~solute:cation symporter activity 4 0.6535947712418301 0.3277378377501566 SLC1A2, SLC1A3, SLC6A14, SLC35A3 368 73 13288 1.9785586658725431 1.0 0.9776976262357469 99.67047772313889 GOTERM_MF_FAT GO:0015370~solute:sodium symporter activity 3 0.49019607843137253 0.3641728615602592 SLC1A2, SLC1A3, SLC6A14 368 46 13288 2.354914933837429 1.0 0.9795153529420282 99.85222642818911 SP_PIR_KEYWORDS Symport 5 0.8169934640522877 0.36748908513597023 SLC1A2, SLC1A3, SLC6A14, SLC22A5, SLC36A4 503 109 17854 1.628212377113466 1.0 0.9590927035482396 99.7938162253052 GOTERM_MF_FAT GO:0015171~amino acid transmembrane transporter activity 3 0.49019607843137253 0.4036517022388649 SLC1A2, SLC1A3, SLC7A6 368 50 13288 2.1665217391304346 1.0 0.9842689418874994 99.94126074565851 Annotation Cluster 14 Enrichment Score: 0.8980336085706644 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04740:Olfactory transduction 35 5.718954248366013 0.013080719843379959 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR691, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR576, OLFR1109, OLFR976, OLFR895, OLFR1099, OLFR715, OLFR791, OLFR448, OLFR1518, GNAL, OLFR629, OLFR350, OLFR1472, OLFR1471, OLFR1161, OLFR1121, OLFR354, OLFR1140 141 960 5738 1.4836731678486998 0.7828951812227998 0.7828951812227998 13.948165054836902 PIR_SUPERFAMILY PIRSF003152:G protein-coupled olfactory receptor, class II 32 5.228758169934641 0.036783487372499465 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR1109, OLFR976, OLFR1282, OLFR895, OLFR304, OLFR1099, OLFR715, OLFR791, OLFR448, OLFR1518, OLFR350, OLFR1472, OLFR1161, OLFR1121, OLFR354, OLFR1140 203 901 8136 1.4234430271783405 0.9994011252564917 0.9755280825535015 37.4349289992679 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 39 6.372549019607843 0.0640817079875999 OLFR845, OLFR706, OLFR1295, OLFR1086, FPR1, OLFR136, OLFR801, OLFR1420, OLFR435, GPR141, OLFR805, OLFR1377, OLFR745, PTGIR, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, MRGPRB2, OLFR1109, OLFR976, OLFR1282, MRGPRB5, OLFR895, OLFR304, OLFR1099, OLFR715, OLFR791, OLFR448, OLFR1518, OLFR350, DARC, OLFR1472, OLFR1161, TSHR, OLFR1121, OLFR354, OLFR1140 203 1200 8136 1.3025615763546798 0.9999979811167226 0.98736126124713 56.33930556207126 SP_PIR_KEYWORDS g-protein coupled receptor 50 8.169934640522875 0.07223065983879653 OLFR845, OLFR1295, GPR161, OLFR801, OLFR1420, OLFR805, OLFR745, LPHN3, OLFR691, PTGIR, OLFR741, TAS2R140, OLFR1312, CALCRL, MRGPRB2, OLFR1109, OLFR1282, MRGPRB5, GRM5, OLFR629, OLFR350, DARC, OLFR1472, OLFR1471, TSHR, OLFR354, OLFR1140, OLFR1086, FPR1, OLFR136, OLFR435, GCGR, GPR141, OLFR1377, OLFR381, OLFR45, OLFR382, OLFR576, OLFR1175, OLFR1182, GPR156, OLFR895, OLFR304, OLFR1099, FZD5, OLFR791, OLFR448, OLFR1518, OLFR1161, OLFR1121 503 1411 17854 1.2577969461755336 0.9999999999646617 0.7777891153929801 63.65761671954269 SP_PIR_KEYWORDS transducer 51 8.333333333333332 0.08935804766899706 OLFR845, OLFR1295, GPR161, OLFR801, OLFR1420, OLFR805, OLFR745, LPHN3, OLFR691, PTGIR, OLFR741, TAS2R140, OLFR1312, CALCRL, MRGPRB2, OLFR1109, OLFR1282, MRGPRB5, GRM5, OLFR629, GNAL, OLFR350, DARC, OLFR1472, OLFR1471, TSHR, OLFR354, OLFR1140, OLFR1086, FPR1, OLFR136, OLFR435, GCGR, GPR141, OLFR1377, OLFR381, OLFR45, OLFR382, OLFR576, OLFR1175, OLFR1182, GPR156, OLFR895, OLFR304, OLFR1099, FZD5, OLFR791, OLFR448, OLFR1518, OLFR1161, OLFR1121 503 1467 17854 1.2339785418369131 0.9999999999999107 0.7943213035708261 71.74080107623023 GOTERM_BP_FAT GO:0050890~cognition 50 8.169934640522875 0.0938470249791227 OLFR845, OLFR1295, OLFR706, RORB, OLFR801, OLFR1420, OLFR805, OLFR745, OLFR691, SLC1A3, OLFR741, IAPP, TAS2R140, ADAM2, OLFR1312, MKKS, OLFR1109, OLFR976, OLFR1282, RPGR, TMIE, GRM5, OLFR629, GNAL, OLFR350, SLC26A5, OLFR1472, OLFR1471, CLN8, OLFR354, OLFR1140, OLFR1086, OLFR136, OLFR435, OLFR1377, OLFR381, OLFR45, OLFR382, OLFR576, OLFR1175, OLFR895, OLFR304, OLFR715, OLFR1099, OLFR791, OLFR448, FOXP2, OLFR1518, OLFR1161, OLFR1121 375 1480 13588 1.224144144144144 1.0 0.9911213303915313 80.63756797550742 GOTERM_BP_FAT GO:0050877~neurological system process 56 9.15032679738562 0.09646362592330977 SYT1, GM98, OLFR845, OLFR706, OLFR1295, RORB, OLFR801, OLFR1420, OLFR805, OLFR745, OLFR691, SLC1A3, OLFR741, IAPP, TAS2R140, ADAM2, OLFR1312, GRID2, MKKS, OLFR1109, OLFR976, RPGR, OLFR1282, TMIE, GRM5, OLFR629, GNAL, OLFR350, SLC26A5, OLFR1472, OLFR1471, VAMP2, CLN8, OLFR354, OLFR1140, OLFR1086, OLFR136, OLFR435, OLFR1377, OLFR381, OLFR45, OLFR382, AGT, OLFR576, OLFR1175, OLFR895, OLFR304, OLFR715, OLFR1099, TNNI3, OLFR791, OLFR448, FOXP2, OLFR1518, OLFR1161, OLFR1121 375 1681 13588 1.207103708110252 1.0 0.9910434699082314 81.54829777420034 GOTERM_BP_FAT GO:0007608~sensory perception of smell 39 6.372549019607843 0.1008051717375767 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR691, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR576, MKKS, OLFR1175, OLFR1109, OLFR976, OLFR1282, OLFR895, OLFR304, OLFR715, OLFR1099, OLFR791, OLFR448, OLFR1518, GNAL, OLFR629, OLFR350, OLFR1472, OLFR1471, OLFR1161, OLFR1121, OLFR354, OLFR1140 375 1117 13588 1.2651316025067143 1.0 0.9905053711253899 82.97114202244612 GOTERM_BP_FAT GO:0007600~sensory perception 47 7.6797385620915035 0.1180004936284646 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, RORB, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR691, OLFR381, SLC1A3, OLFR45, OLFR741, IAPP, OLFR382, TAS2R140, OLFR1312, OLFR576, MKKS, OLFR1175, OLFR1109, OLFR976, RPGR, OLFR1282, OLFR895, TMIE, OLFR304, OLFR715, OLFR1099, OLFR791, OLFR448, OLFR1518, OLFR629, GNAL, OLFR350, SLC26A5, OLFR1472, OLFR1471, OLFR1161, CLN8, OLFR1121, OLFR354, OLFR1140 375 1402 13588 1.2147142177841177 1.0 0.989807138742276 87.65530474020328 GOTERM_BP_FAT GO:0007606~sensory perception of chemical stimulus 40 6.535947712418301 0.1451918996959462 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR691, OLFR381, OLFR45, OLFR741, OLFR382, TAS2R140, OLFR1312, OLFR576, MKKS, OLFR1175, OLFR1109, OLFR976, OLFR1282, OLFR895, OLFR304, OLFR715, OLFR1099, OLFR791, OLFR448, OLFR1518, OLFR629, GNAL, OLFR350, OLFR1472, OLFR1471, OLFR1161, OLFR1121, OLFR354, OLFR1140 375 1192 13588 1.2159284116331097 1.0 0.990224824703284 92.6733808772636 GOTERM_MF_FAT GO:0004984~olfactory receptor activity 38 6.209150326797386 0.16705457132273382 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR691, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR576, OLFR1175, OLFR1182, OLFR1109, OLFR976, OLFR1282, OLFR895, OLFR304, OLFR1099, OLFR715, OLFR791, OLFR448, OLFR1518, OLFR629, OLFR350, OLFR1472, OLFR1471, OLFR1161, OLFR1121, OLFR354, OLFR1140 368 1135 13288 1.2089254932005364 1.0 0.9518900711658818 92.79739558637279 SP_PIR_KEYWORDS receptor 78 12.745098039215685 0.17085591173980427 SLC22A17, OLFR845, OLFR706, OLFR1295, GPR161, GLRA2, RORB, OLFR801, OLFR1420, IL17RB, OLFR805, OLFR745, OLFR691, LPHN3, PTGIR, OLFR741, TAS2R140, OLFR1312, GRID2, CALCRL, MRGPRB2, OLFR1109, OLFR976, MRGPRB5, RARG, OLFR1282, PTPRG, LIFR, ARNTL, NRIP1, GRM5, OLFR629, OLFR350, DARC, OLFR1472, OLFR1471, LCOR, TSHR, OLFR1140, OLFR354, OLFR1086, FPR1, PAQR7, OLFR136, PAQR8, GCGR, OLFR435, GPR141, ARNT, OLFR1377, OLFR381, OLFR45, OLFR382, OLFR576, OLFR1175, OLFR1182, GPR156, TRPC2, ESRRA, OLFR895, MET, MRC2, ITGA1, BMX, OLFR304, OLFR1099, OLFR715, FZD5, OLFR448, OLFR791, OLFR1518, EPHA4, 9830107B12RIK, CHRNB3, GOSR2, CHRNB1, OLFR1161, OLFR1121 503 2465 17854 1.1231693006262626 1.0 0.9010550649749565 92.03037110044863 INTERPRO IPR000725:Olfactory receptor 38 6.209150326797386 0.19202389234512013 OLFR845, OLFR706, OLFR1295, OLFR1086, OLFR136, OLFR801, OLFR1420, OLFR435, OLFR805, OLFR1377, OLFR745, OLFR691, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR576, OLFR1175, OLFR1182, OLFR1109, OLFR976, OLFR1282, OLFR895, OLFR304, OLFR1099, OLFR715, OLFR791, OLFR448, OLFR1518, OLFR629, OLFR350, OLFR1472, OLFR1471, OLFR1161, OLFR1121, OLFR354, OLFR1140 500 1134 17763 1.1904656084656082 1.0 0.9942582517009 96.30252812076027 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 46 7.516339869281046 0.2741771732757196 OLFR845, OLFR706, OLFR1295, GPR161, OLFR1086, FPR1, OLFR136, OLFR801, OLFR1420, OLFR435, GPR141, OLFR805, OLFR1377, OLFR745, OLFR691, PTGIR, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR576, OLFR1175, OLFR1182, MRGPRB2, OLFR1109, OLFR976, OLFR1282, MRGPRB5, OLFR895, OLFR304, OLFR715, OLFR1099, OLFR791, OLFR448, OLFR1518, OLFR629, OLFR350, DARC, OLFR1472, OLFR1471, OLFR1161, TSHR, OLFR1121, OLFR354, OLFR1140 500 1458 17763 1.1208477366255143 1.0 0.9972617808753347 99.29575183942309 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 55 8.986928104575163 0.3848218411856096 OLFR845, OLFR706, OLFR1295, GPR161, OLFR801, OLFR1420, OLFR805, OLFR745, OLFR691, LPHN3, PTGIR, OLFR741, TAS2R140, OLFR1312, CALCRL, MRGPRB2, OLFR1109, OLFR976, MRGPRB5, OLFR1282, GRM5, OLFR629, GNAL, OLFR350, DARC, OLFR1472, OLFR1471, TSHR, OLFR354, OLFR1140, OLFR1086, FPR1, OLFR136, OLFR435, GCGR, GPR141, OLFR1377, OLFR381, OLFR45, OLFR382, DGKG, OLFR576, OLFR1175, OLFR1182, GPR156, OLFR895, OLFR304, OLFR715, OLFR1099, FZD5, OLFR791, OLFR448, OLFR1518, OLFR1161, OLFR1121 375 1877 13588 1.0617510211330137 1.0 0.9979921638313091 99.96947404870706 INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 45 7.352941176470589 0.5392335142592081 OLFR845, OLFR706, OLFR1295, GPR161, OLFR1086, FPR1, OLFR136, OLFR801, OLFR1420, OLFR435, GPR141, OLFR805, OLFR1377, OLFR745, OLFR691, PTGIR, OLFR381, OLFR45, OLFR741, OLFR382, OLFR1312, OLFR576, OLFR1175, OLFR1182, MRGPRB2, OLFR1109, OLFR976, OLFR1282, MRGPRB5, OLFR895, OLFR304, OLFR715, OLFR1099, OLFR791, OLFR448, OLFR1518, OLFR629, OLFR350, OLFR1472, OLFR1471, OLFR1161, TSHR, OLFR1121, OLFR354, OLFR1140 500 1575 17763 1.0150285714285714 1.0 0.999875417721366 99.99937528225269 GOTERM_BP_FAT GO:0007166~cell surface receptor linked signal transduction 69 11.27450980392157 0.5578919964777286 OLFR845, OLFR706, OLFR1295, GPR161, OLFR801, OLFR1420, OLFR805, OLFR745, OLFR691, LPHN3, PTGIR, OLFR741, TAS2R140, OLFR1312, CALCRL, MRGPRB2, SGPL1, OLFR1109, OLFR976, MRGPRB5, OLFR1282, GRM5, GNAL, OLFR629, OLFR350, DARC, OLFR1472, RNF138, OLFR1471, CSNK1G3, TSHR, OLFR1140, OLFR354, OLFR1086, FPR1, OLFR136, GCGR, OLFR435, GPR141, OLFR1377, PHIP, OLFR381, SORBS1, OLFR45, OLFR382, DGKG, OLFR576, ADAM33, ADAM30, OLFR1175, OLFR1182, NSDHL, GPR156, OLFR895, MYO1E, CBL, MET, ITGA1, OLFR304, OLFR1099, OLFR715, FZD5, OLFR448, OLFR791, OLFR1518, EPHA4, HEYL, OLFR1161, OLFR1121 375 2495 13588 1.0020809619238478 1.0 0.9992501997567408 99.99987573225437 Annotation Cluster 15 Enrichment Score: 0.8770795275420648 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000086~G2/M transition of mitotic cell cycle 3 0.49019607843137253 0.014477717861311164 PPM1D, TPD52L1, CHEK1 375 7 13588 15.529142857142858 0.9999999998075442 0.916731406271819 21.57032002818965 GOTERM_BP_FAT GO:0051329~interphase of mitotic cell cycle 3 0.49019607843137253 0.3922297548292884 PPM1D, TPD52L1, CHEK1 375 49 13588 2.218448979591837 1.0 0.997991385075312 99.97505342580075 GOTERM_BP_FAT GO:0051325~interphase 3 0.49019607843137253 0.4116430353973778 PPM1D, TPD52L1, CHEK1 375 51 13588 2.131450980392157 1.0 0.99817740154719 99.98547475154048 Annotation Cluster 16 Enrichment Score: 0.7969013820197521 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015943:WD40/YVTN repeat-like 15 2.450980392156863 0.0500018053201921 2610029G23RIK, MET, PPP3R1, KCTD3, PRPF4, CORO2B, PHIP, ERCC8, WDR17, SEMA6D, STXBP5, FBXW14, CIRH1A, WDHD1, NUP43 500 305 17763 1.7471803278688525 1.0 0.8983973626455033 54.764477160445765 SMART SM00320:WD40 12 1.9607843137254901 0.10337283185536982 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, PPP3R1, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 253 259 9131 1.672165672165672 0.9999999994254613 0.9300295097734818 74.38453840754792 UP_SEQ_FEATURE repeat:WD 5 10 1.6339869281045754 0.10800738179196362 CORO2B, PHIP, ERCC8, STXBP5, 2610029G23RIK, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 444 202 16021 1.7863036303630362 1.0 0.9989139292507917 84.40048375243548 INTERPRO IPR017986:WD40 repeat, region 11 1.7973856209150325 0.11028422697699655 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, PPP3R1, CIRH1A, WDHD1, NUP43, PRPF4 500 228 17763 1.7139736842105262 1.0 0.9864754261981968 83.5879074217891 INTERPRO IPR001680:WD40 repeat 12 1.9607843137254901 0.11495983342285016 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, PPP3R1, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 500 259 17763 1.645992277992278 1.0 0.9865650761605466 84.87222917087772 SP_PIR_KEYWORDS wd repeat 12 1.9607843137254901 0.12435578123097082 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, PPP3R1, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 503 263 17854 1.61954508689309 1.0 0.8432905892204325 83.35145654120461 INTERPRO IPR019781:WD40 repeat, subgroup 11 1.7973856209150325 0.12700120497225037 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, PPP3R1, CIRH1A, WDHD1, NUP43, PRPF4 500 235 17763 1.66291914893617 1.0 0.9899644248453641 87.76038961420922 INTERPRO IPR019782:WD40 repeat 2 10 1.6339869281045754 0.14981164452773515 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, PPP3R1, WDHD1, NUP43, PRPF4 500 214 17763 1.6600934579439253 1.0 0.993850154218543 91.87278448560534 UP_SEQ_FEATURE repeat:WD 4 10 1.6339869281045754 0.1503235863537898 CORO2B, PHIP, ERCC8, STXBP5, 2610029G23RIK, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 444 218 16021 1.6551987767584098 1.0 0.9991273773694099 92.92052972444036 UP_SEQ_FEATURE repeat:WD 3 10 1.6339869281045754 0.18983738178857978 CORO2B, PHIP, ERCC8, STXBP5, 2610029G23RIK, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 444 231 16021 1.562049062049062 1.0 0.9994700040454856 96.73547069784067 INTERPRO IPR019775:WD40 repeat, conserved site 11 1.7973856209150325 0.19133940637220426 CORO2B, PHIP, ERCC8, WDR17, STXBP5, 2610029G23RIK, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 500 258 17763 1.514674418604651 1.0 0.9949615694545634 96.25378786573691 UP_SEQ_FEATURE repeat:WD 1 10 1.6339869281045754 0.20046331002802514 CORO2B, PHIP, ERCC8, STXBP5, 2610029G23RIK, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 444 235 16021 1.5354609929078014 1.0 0.9993781765004454 97.36599665954124 UP_SEQ_FEATURE repeat:WD 2 10 1.6339869281045754 0.20046331002802514 CORO2B, PHIP, ERCC8, STXBP5, 2610029G23RIK, KCTD3, CIRH1A, WDHD1, NUP43, PRPF4 444 235 16021 1.5354609929078014 1.0 0.9993781765004454 97.36599665954124 UP_SEQ_FEATURE repeat:WD 6 7 1.1437908496732025 0.28703680518085084 PHIP, STXBP5, 2610029G23RIK, CIRH1A, WDHD1, NUP43, PRPF4 444 161 16021 1.5688405797101448 1.0 0.9997138084102136 99.59114165550363 UP_SEQ_FEATURE repeat:WD 8 3 0.49019607843137253 0.37466083221684376 PHIP, STXBP5, CIRH1A 444 47 16021 2.3031914893617023 1.0 0.9997493890609344 99.95149195567863 UP_SEQ_FEATURE repeat:WD 7 5 0.8169934640522877 0.44956704353690013 PHIP, STXBP5, CIRH1A, WDHD1, PRPF4 444 124 16021 1.4549731182795698 1.0 0.9999321851121176 99.9939033366335 Annotation Cluster 17 Enrichment Score: 0.7903365278998302 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014075~response to amine stimulus 3 0.49019607843137253 0.10372895881722943 GNAL, SLC1A2, SLC1A3 375 20 13588 5.4352 1.0 0.9893300653740563 83.8705170826596 GOTERM_BP_FAT GO:0010243~response to organic nitrogen 3 0.49019607843137253 0.10372895881722943 GNAL, SLC1A2, SLC1A3 375 20 13588 5.4352 1.0 0.9893300653740563 83.8705170826596 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 7 1.1437908496732025 0.39553997245315703 PHIP, GNAL, SLC1A2, SLC1A3, SORBS1, ACADS, STEAP2 375 184 13588 1.3784927536231886 1.0 0.9980261894473489 99.9772230816453 Annotation Cluster 18 Enrichment Score: 0.7774603409987639 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001654~eye development 9 1.4705882352941175 0.06868696166855671 RAX, RARG, RPGR, YY1, RORB, COL8A2, CLN8, FOXP2, DLG1 375 157 13588 2.0771464968152866 1.0 0.9873027077775717 69.44224137747237 GOTERM_BP_FAT GO:0048592~eye morphogenesis 5 0.8169934640522877 0.1415197905124465 RARG, RPGR, YY1, RORB, COL8A2 375 73 13588 2.481826484018265 1.0 0.9898442731700705 92.13099882509934 GOTERM_BP_FAT GO:0007423~sensory organ development 10 1.6339869281045754 0.2775473606990385 RAX, RARG, RPGR, TMIE, YY1, RORB, COL8A2, CLN8, FOXP2, DLG1 375 257 13588 1.4099092088197147 1.0 0.9963149375365399 99.55566879869573 GOTERM_BP_FAT GO:0043010~camera-type eye development 6 0.9803921568627451 0.2878260191707642 RAX, YY1, COL8A2, CLN8, FOXP2, DLG1 375 130 13588 1.6723692307692308 1.0 0.9958346309034256 99.6500351356995 Annotation Cluster 19 Enrichment Score: 0.7735000001542859 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 17 2.7777777777777777 0.08213747410325112 MBD3L1, RARG, RFX5, DEDD, SIRT5, NFKB1, POT1B, MXD3, PURB, FOXP2, NRIP1, TRIM66, RNF2, RAD18, PATZ1, LCOR, HELLS 375 397 13588 1.551610411418976 1.0 0.9892584870212603 76.01938541706318 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 17 2.7777777777777777 0.08878064858822271 MBD3L1, RARG, RFX5, DEDD, SIRT5, NFKB1, POT1B, MXD3, PURB, FOXP2, NRIP1, TRIM66, RNF2, RAD18, PATZ1, LCOR, HELLS 375 401 13588 1.5361330008312553 1.0 0.9899541546935892 78.7528031160373 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 20 3.2679738562091507 0.1065141970945498 MBD3L1, RARG, RFX5, DEDD, DICER1, SIRT5, NFKB1, POT1B, ANKHD1, MXD3, PURB, NRIP1, FOXP2, TRIM66, EIF2AK1, RNF2, RAD18, PATZ1, LCOR, HELLS 375 506 13588 1.4322002635046114 1.0 0.9893956046951345 84.68558420728831 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 17 2.7777777777777777 0.11458545755348233 MBD3L1, RARG, RFX5, DEDD, SIRT5, NFKB1, ANKHD1, MXD3, PURB, FOXP2, NRIP1, TRIM66, EIF2AK1, RNF2, PATZ1, LCOR, HELLS 375 418 13588 1.4736586921850081 1.0 0.989467989719107 86.83436897839323 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 17 2.7777777777777777 0.1385061132560977 MBD3L1, RARG, RFX5, DEDD, SIRT5, NFKB1, ANKHD1, MXD3, PURB, FOXP2, NRIP1, TRIM66, EIF2AK1, RNF2, PATZ1, LCOR, HELLS 375 430 13588 1.4325333333333334 1.0 0.9914735504882689 91.65790202086527 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 15 2.450980392156863 0.14674086286863233 MBD3L1, RARG, RFX5, DEDD, SIRT5, NFKB1, MXD3, PURB, FOXP2, NRIP1, TRIM66, RNF2, PATZ1, LCOR, HELLS 375 372 13588 1.4610752688172044 1.0 0.989878414234943 92.89145817051417 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 17 2.7777777777777777 0.14782988377419798 MBD3L1, RARG, RFX5, DEDD, SIRT5, NFKB1, ANKHD1, MXD3, PURB, FOXP2, NRIP1, TRIM66, EIF2AK1, RNF2, PATZ1, LCOR, HELLS 375 434 13588 1.419330261136713 1.0 0.9893724707203214 93.04111156300763 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 16 2.6143790849673203 0.1629739908538816 MBD3L1, RARG, RFX5, DEDD, DICER1, SIRT5, NFKB1, MXD3, PURB, FOXP2, NRIP1, TRIM66, RNF2, PATZ1, LCOR, HELLS 375 410 13588 1.4140357723577235 1.0 0.9923510965115978 94.83821990332689 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 12 1.9607843137254901 0.22856769584527004 MBD3L1, TRIM66, RARG, RFX5, RNF2, SIRT5, NFKB1, LCOR, HELLS, PURB, FOXP2, NRIP1 375 308 13588 1.4117402597402597 1.0 0.9950470405743993 98.67463404956375 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 12 1.9607843137254901 0.23590763111223828 MBD3L1, TRIM66, RARG, RFX5, RNF2, SIRT5, NFKB1, LCOR, HELLS, PURB, FOXP2, NRIP1 375 310 13588 1.4026322580645163 1.0 0.9949665167706924 98.86978131418077 GOTERM_MF_FAT GO:0016564~transcription repressor activity 8 1.3071895424836601 0.36171349868565955 TRIM66, RNF2, ZFP263, PATZ1, NFKB1, PURB, FOXP2, NRIP1 368 211 13288 1.3690500721203378 1.0 0.9802096895145023 99.84378350424372 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 7 1.1437908496732025 0.6145839821560968 MBD3L1, RARG, RFX5, RNF2, LCOR, FOXP2, NRIP1 375 231 13588 1.0980202020202021 1.0 0.9992829887025277 99.9999873694812 Annotation Cluster 20 Enrichment Score: 0.7725874358361217 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS atp-binding 48 7.8431372549019605 0.03931886671864297 D5ERTD579E, NEK1, DICER1, TTK, CHEK1, CCT3, RIOK1, C230081A13RIK, ABCA3, KIFC3, FANCM, CHD9, VRK1, VRK2, KIF7, SLK, DHX37, DGKG, DHX33, MKKS, TAF9, TLK2, SLC22A5, HELLS, ABCA12, PDK2, TNIK, MYO1E, MET, SMC5, BMX, PKN2, SMC6, RPS6KC1, WRN, MARK3, HLTF, DDX4, STK3, NME6, EPHA4, PEO1, EIF2AK1, HELB, ATP2A1, UBE2W, CARS2, CSNK1G3 503 1287 17854 1.3238239560307155 0.9999974417498264 0.6898075786151182 41.81571720211718 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 35 5.718954248366013 0.04387864497944534 D5ERTD579E, NEK1, DICER1, TTK, CHEK1, C230081A13RIK, KIFC3, FANCM, CHD9, VRK1, VRK2, SLK, MKKS, DHX33, TAF9, TLK2, SLC22A5, HELLS, PDK2, TNIK, MET, PKN2, BMX, SMC5, SMC6, RPS6KC1, WRN, MARK3, HLTF, DDX4, STK3, PEO1, EPHA4, EIF2AK1, CSNK1G3 444 907 16021 1.3924108783535465 1.0 0.9868096668582089 51.77916429574188 GOTERM_MF_FAT GO:0001882~nucleoside binding 55 8.986928104575163 0.045447871926743 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, ACADS, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, EIF2AK1, UBE2W, CSNK1G3, STEAP2, ACADSB, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, IVD, DGKG, TAF9, HELLS, ABCA12, PDK2, MYO1E, MET, SMC5, BMX, SMC6, POLR3A, WRN, DDX4, PEO1, EPHA4, HELB, ATP2A1, CARS2, ACAD11 368 1558 13288 1.2746972149355362 0.9999999999128584 0.9013669235185384 48.79993570096628 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 54 8.823529411764707 0.04965255291727127 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, ACADS, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, EIF2AK1, UBE2W, CSNK1G3, STEAP2, ACADSB, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, IVD, DGKG, TAF9, HELLS, ABCA12, PDK2, MYO1E, MET, SMC5, BMX, SMC6, WRN, DDX4, PEO1, EPHA4, HELB, ATP2A1, CARS2, ACAD11 368 1535 13288 1.2702733323891802 0.9999999999903296 0.90030428576758 51.95180856989601 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 54 8.823529411764707 0.058281444065867674 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, ACADS, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, EIF2AK1, UBE2W, CSNK1G3, STEAP2, ACADSB, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, IVD, DGKG, TAF9, HELLS, ABCA12, PDK2, MYO1E, MET, SMC5, BMX, SMC6, WRN, DDX4, PEO1, EPHA4, HELB, ATP2A1, CARS2, ACAD11 368 1548 13288 1.2596056622851366 0.9999999999998971 0.9172578481199228 57.86286034957347 UP_SEQ_FEATURE binding site:ATP 22 3.594771241830065 0.07908877178859808 PDK2, TNIK, NEK1, MET, BMX, PKN2, TTK, RPS6KC1, CHEK1, MARK3, RIOK1, C230081A13RIK, STK3, NME6, EPHA4, VRK1, VRK2, EIF2AK1, SLK, CARS2, TLK2, CSNK1G3 444 545 16021 1.4565749235474006 1.0 0.9977063128005151 73.7969539994573 GOTERM_MF_FAT GO:0005524~ATP binding 49 8.006535947712418 0.09873787391328684 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, PKN2, RPS6KC1, HLTF, MARK3, STK3, NME6, EIF2AK1, UBE2W, CSNK1G3, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, DGKG, TAF9, HELLS, ABCA12, PDK2, MYO1E, MET, SMC5, BMX, SMC6, WRN, DDX4, PEO1, EPHA4, HELB, ATP2A1, CARS2 368 1443 13288 1.226144204405074 1.0 0.9606684427799246 77.60228103719241 UP_SEQ_FEATURE active site:Proton acceptor 25 4.084967320261438 0.10683489685627731 ACADSB, NEK1, TTK, CHEK1, RIOK1, C230081A13RIK, VRK1, VRK2, SLK, IVD, TLK2, SULT3A1, NSDHL, TNIK, ACADS, MET, PKN2, BMX, SIRT5, RPS6KC1, MARK3, STK3, EPHA4, EIF2AK1, CSNK1G3 444 662 16021 1.3626636455186305 1.0 0.9991616593984821 84.06380959165237 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 49 8.006535947712418 0.11373481728242082 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, PKN2, RPS6KC1, HLTF, MARK3, STK3, NME6, EIF2AK1, UBE2W, CSNK1G3, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, DGKG, TAF9, HELLS, ABCA12, PDK2, MYO1E, MET, SMC5, BMX, SMC6, WRN, DDX4, PEO1, EPHA4, HELB, ATP2A1, CARS2 368 1460 13288 1.211867182846933 1.0 0.9577704289718596 82.40777089557798 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 61 9.967320261437909 0.11622211149036374 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, ACADS, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, GNAL, EIF2AK1, UBE2W, CSNK1G3, STEAP2, ACADSB, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, IVD, DGKG, TAF9, GUF1, HELLS, ABCA12, RHEBL1, PDK2, DNM1L, MYO1E, MET, SMC5, BMX, SMC6, DOCK8, WRN, DOCK6, DDX4, PEO1, EPHA4, GSPT1, HELB, ATP2A1, CARS2, ACAD11 368 1871 13288 1.1772476936304697 1.0 0.9538741930026973 83.10515328633691 INTERPRO IPR017441:Protein kinase, ATP binding site 18 2.941176470588235 0.16989011755262365 TNIK, NEK1, MET, BMX, PKN2, TTK, RPS6KC1, CHEK1, MARK3, C230081A13RIK, STK3, EPHA4, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3 500 467 17763 1.3693104925053532 1.0 0.9947889169719076 94.38408827212757 UP_SEQ_FEATURE domain:Protein kinase 18 2.941176470588235 0.17053846256734329 TNIK, NEK1, MET, BMX, PKN2, TTK, CHEK1, MARK3, RIOK1, C230081A13RIK, STK3, EPHA4, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3 444 476 16021 1.3644957983193278 1.0 0.9991791617423831 95.21353561048707 GOTERM_MF_FAT GO:0000166~nucleotide binding 68 11.11111111111111 0.18665785488122422 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, CNOT4, FANCM, SLK, DHX37, DHX33, MKKS, SLC22A5, TLK2, HFM1, TNIK, ACADS, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, GNAL, EIF2AK1, UBE2W, CSNK1G3, STEAP2, ACADSB, NEK1, CHEK1, RIOK1, ABCA3, HADHA, CHD9, VRK1, VRK2, KIF7, IVD, DGKG, MSI2, TAF9, GUF1, HELLS, RHEBL1, ABCA12, RBM26, PDK2, ALKBH8, DNM1L, MYO1E, MET, SMC5, BMX, SMC6, SIRT5, WRN, DOCK8, DOCK6, DDX4, EPHA4, PEO1, UPF3B, GSPT1, HELB, ATP2A1, CARS2, ACAD11 368 2183 13288 1.1247784261785734 1.0 0.959855332022937 94.88758516933045 GOTERM_MF_FAT GO:0004672~protein kinase activity 21 3.431372549019608 0.18694529897320916 PDK2, TNIK, NEK1, MET, BMX, PKN2, TTK, RPS6KC1, CHEK1, MARK3, RIOK1, C230081A13RIK, STK3, EPHA4, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3, KCNH5 368 583 13288 1.300656275635767 1.0 0.9559824822688733 94.91352749619872 SP_PIR_KEYWORDS nucleotide-binding 53 8.660130718954248 0.1876225413238673 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, TNIK, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, GNAL, EIF2AK1, UBE2W, CSNK1G3, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, DGKG, TAF9, GUF1, HELLS, ABCA12, RHEBL1, PDK2, DNM1L, MYO1E, MET, SMC5, BMX, SMC6, WRN, DDX4, PEO1, EPHA4, GSPT1, HELB, ATP2A1, CARS2 503 1631 17854 1.1534252486308392 1.0 0.915448507823376 93.95137242319709 SP_PIR_KEYWORDS kinase 25 4.084967320261438 0.19475302029084807 NEK1, TTK, CHEK1, RIOK1, MOBKL2C, C230081A13RIK, VRK1, VRK2, SLK, DGKG, TAF9, TLK2, JAKMIP1, PDK2, TNIK, MET, PKN2, BMX, RPS6KC1, MARK3, STK3, NME6, EPHA4, EIF2AK1, CSNK1G3 503 707 17854 1.2551283529375374 1.0 0.9165273161664038 94.63010944643125 SP_PIR_KEYWORDS serine/threonine-protein kinase 15 2.450980392156863 0.1951356087289815 TNIK, NEK1, PKN2, TTK, RPS6KC1, CHEK1, RIOK1, MARK3, STK3, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3 503 384 17854 1.3865246023856856 1.0 0.9095417940772901 94.66445251901857 INTERPRO IPR008271:Serine/threonine protein kinase, active site 14 2.287581699346405 0.21550438518547757 TNIK, NEK1, PKN2, TTK, RPS6KC1, CHEK1, MARK3, STK3, VRK1, VRK2, EIF2AK1, SLK, CSNK1G3, TLK2 500 360 17763 1.3815666666666668 1.0 0.9955282431982294 97.65670288059579 SP_PIR_KEYWORDS transferase 45 7.352941176470589 0.21849211613010017 RNMT, COX10, NEK1, TTK, CHEK1, RG9MTD3, TRPT1, RIOK1, C230081A13RIK, PDSS1, VRK1, STT3A, VRK2, ZDHHC21, XYLT2, GNPTAB, SLK, DGKG, TAF9, TLK2, PDHX, SULT3A1, B4GALNT1, PDK2, ZDHHC3, TNIK, METTL5, MET, FTCD, GALNTL2, PKN2, BMX, RPS6KC1, WHSC1, POLR3A, UAP1L1, MARK3, STK3, NME6, EPHA4, EIF2AK1, SULT1D1, SETD8, CSNK1G3, PARP2 503 1385 17854 1.153268116930188 1.0 0.8957572184228536 96.41480958033975 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 56 9.15032679738562 0.22111668355008696 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, GNAL, EIF2AK1, UBE2W, CSNK1G3, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, DGKG, TAF9, GUF1, HELLS, ABCA12, RHEBL1, PDK2, DNM1L, MYO1E, MET, SMC5, BMX, SMC6, DOCK8, WRN, DDX4, DOCK6, PEO1, EPHA4, GSPT1, HELB, ATP2A1, CARS2 368 1796 13288 1.1258836060811466 1.0 0.9714367703467827 97.25818436848245 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 56 9.15032679738562 0.22111668355008696 D5ERTD579E, DICER1, TTK, CCT3, C230081A13RIK, KIFC3, FANCM, SLK, DHX37, DHX33, MKKS, TLK2, SLC22A5, HFM1, TNIK, PKN2, RPS6KC1, MARK3, HLTF, STK3, NME6, GNAL, EIF2AK1, UBE2W, CSNK1G3, NEK1, CHEK1, RIOK1, ABCA3, CHD9, VRK1, VRK2, KIF7, DGKG, TAF9, GUF1, HELLS, ABCA12, RHEBL1, PDK2, DNM1L, MYO1E, MET, SMC5, BMX, SMC6, DOCK8, WRN, DDX4, DOCK6, PEO1, EPHA4, GSPT1, HELB, ATP2A1, CARS2 368 1796 13288 1.1258836060811466 1.0 0.9714367703467827 97.25818436848245 INTERPRO IPR000719:Protein kinase, core 18 2.941176470588235 0.2244261556117726 TNIK, NEK1, MET, BMX, PKN2, TTK, RPS6KC1, CHEK1, MARK3, C230081A13RIK, STK3, EPHA4, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3 500 491 17763 1.3023788187372707 1.0 0.9933037319142087 98.0366110765916 GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 15 2.450980392156863 0.28357373857874396 TNIK, NEK1, PKN2, TTK, RPS6KC1, CHEK1, RIOK1, MARK3, STK3, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3 368 421 13288 1.2865330992461015 1.0 0.9707965500409157 99.17664951922158 INTERPRO IPR017442:Serine/threonine protein kinase-related 13 2.1241830065359477 0.3670516656094043 TNIK, NEK1, PKN2, TTK, RPS6KC1, CHEK1, MARK3, STK3, VRK2, EIF2AK1, SLK, CSNK1G3, TLK2 500 374 17763 1.234860962566845 1.0 0.998743126184317 99.91525153813322 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 20 3.2679738562091507 0.4036806623823638 PDK2, TNIK, NEK1, MET, PKN2, BMX, TTK, RPS6KC1, ABI1, CHEK1, MARK3, C230081A13RIK, STK3, EPHA4, VRK1, VRK2, EIF2AK1, SLK, TLK2, CSNK1G3 375 640 13588 1.1323333333333334 1.0 0.998152669426194 99.98182866094936 GOTERM_BP_FAT GO:0016310~phosphorylation 22 3.594771241830065 0.4193666354529878 PDK2, TNIK, NEK1, MET, PKN2, BMX, TTK, RPS6KC1, ABI1, CHEK1, MARK3, C230081A13RIK, STK3, EPHA4, VRK1, VRK2, EIF2AK1, SLK, GNPTAB, ATP6V0A1, TLK2, CSNK1G3 375 718 13588 1.1102544103992573 1.0 0.9981959236276843 99.98834503491838 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 26 4.248366013071895 0.4315623839894741 NEK1, TTK, ABI1, CHEK1, C230081A13RIK, VRK1, VRK2, SLK, GNPTAB, SYNJ2, TLK2, PDK2, TNIK, PTPRG, MET, PKN2, BMX, RPS6KC1, MARK3, STK3, EPHA4, PPM1D, EIF2AK1, PPM1K, ATP6V0A1, CSNK1G3 375 866 13588 1.0878768283294842 1.0 0.9981247104638636 99.99181694047469 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 26 4.248366013071895 0.4315623839894741 NEK1, TTK, ABI1, CHEK1, C230081A13RIK, VRK1, VRK2, SLK, GNPTAB, SYNJ2, TLK2, PDK2, TNIK, PTPRG, MET, PKN2, BMX, RPS6KC1, MARK3, STK3, EPHA4, PPM1D, EIF2AK1, PPM1K, ATP6V0A1, CSNK1G3 375 866 13588 1.0878768283294842 1.0 0.9981247104638636 99.99181694047469 SMART SM00220:S_TKc 9 1.4705882352941175 0.45068286516785516 TNIK, SLK, NEK1, PKN2, TTK, CHEK1, TLK2, MARK3, STK3 253 265 9131 1.225728987993139 1.0 0.9867887185569412 99.94344442869341 INTERPRO IPR002290:Serine/threonine protein kinase 9 1.4705882352941175 0.48194192814794523 TNIK, SLK, NEK1, PKN2, TTK, CHEK1, TLK2, MARK3, STK3 500 265 17763 1.206543396226415 1.0 0.9996881886466951 99.99617332215409 Annotation Cluster 21 Enrichment Score: 0.7474706619003919 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PAC 3 0.49019607843137253 0.14151510798506567 ARNTL, KCNH5, ARNT 444 24 16021 4.510416666666667 1.0 0.9989231140895282 91.62838127076584 SMART SM00086:PAC 3 0.49019607843137253 0.16034791497375792 ARNTL, KCNH5, ARNT 253 26 9131 4.164335664335664 0.9999999999999984 0.9668916353475393 88.71220308981182 INTERPRO IPR001610:PAC motif 3 0.49019607843137253 0.16496479730801608 ARNTL, KCNH5, ARNT 500 26 17763 4.099153846153846 1.0 0.9948329847915941 93.84605908354393 INTERPRO IPR013767:PAS fold 3 0.49019607843137253 0.17503258397429178 ARNTL, KCNH5, ARNT 500 27 17763 3.9473333333333334 1.0 0.993859744692527 94.89867350446592 SMART SM00091:PAS 3 0.49019607843137253 0.22063381083915 ARNTL, KCNH5, ARNT 253 32 9131 3.383522727272727 1.0 0.9762248417463519 95.54631635052229 INTERPRO IPR000014:PAS 3 0.49019607843137253 0.22653100727918024 ARNTL, KCNH5, ARNT 500 32 17763 3.3305625 1.0 0.9928792460156729 98.11741905139357 Annotation Cluster 22 Enrichment Score: 0.7401922537454406 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000902~cell morphogenesis 15 2.450980392156863 0.04707627619484439 COL18A1, CCK, VPREB1, NTNG1, DPYSL5, PPP3R1, CTNNA1, SLIT2, EPHA4, SLC1A3, MKKS, CLASP2, APBB2, DST, ETV4 375 309 13588 1.7589644012944983 1.0 0.9949257671265692 55.21835205462351 GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 16 2.6143790849673203 0.060454484090815906 COL18A1, CCK, COX10, VPREB1, NTNG1, DPYSL5, PPP3R1, CTNNA1, SLIT2, EPHA4, SLC1A3, MKKS, CLASP2, APBB2, DST, ETV4 375 351 13588 1.6517226970560304 1.0 0.9870689515227791 64.61657061427559 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 11 1.7973856209150325 0.06867275548217056 COL18A1, EPHA4, CCK, SLC1A3, NTNG1, PPP3R1, DPYSL5, APBB2, DST, SLIT2, ETV4 375 212 13588 1.8801006289308175 1.0 0.9894044744434117 69.4344746009926 GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 9 1.4705882352941175 0.130003131323421 EPHA4, CCK, SLC1A3, NTNG1, DPYSL5, APBB2, DST, SLIT2, ETV4 375 182 13588 1.791824175824176 1.0 0.9913258837668457 90.17482988933956 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 10 1.6339869281045754 0.13151572233519288 EPHA4, CCK, COX10, NTNG1, DPYSL5, MKKS, APBB2, DST, SLIT2, ETV4 375 212 13588 1.709182389937107 1.0 0.990925044234269 90.45558467027344 GOTERM_BP_FAT GO:0007409~axonogenesis 8 1.3071895424836601 0.16331005781349056 EPHA4, CCK, NTNG1, DPYSL5, APBB2, DST, SLIT2, ETV4 375 163 13588 1.7783885480572597 1.0 0.9917579472488459 94.87263960934149 GOTERM_BP_FAT GO:0048666~neuron development 12 1.9607843137254901 0.1820752632020329 EPHA4, PPP1R9A, CCK, SLC1A3, RPGR, NTNG1, DPYSL5, RORB, APBB2, DST, SLIT2, ETV4 375 292 13588 1.4890958904109588 1.0 0.993618023308992 96.48626706331196 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 9 1.4705882352941175 0.19396569201222638 EPHA4, CCK, NTNG1, DPYSL5, MKKS, APBB2, DST, SLIT2, ETV4 375 202 13588 1.6144158415841583 1.0 0.9943060832676726 97.24696562155303 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 8 1.3071895424836601 0.2120129658412561 EPHA4, CCK, NTNG1, DPYSL5, APBB2, DST, SLIT2, ETV4 375 176 13588 1.647030303030303 1.0 0.9949947705020833 98.11215821921505 GOTERM_BP_FAT GO:0031175~neuron projection development 9 1.4705882352941175 0.2527681334486682 EPHA4, PPP1R9A, CCK, NTNG1, DPYSL5, APBB2, DST, SLIT2, ETV4 375 218 13588 1.495926605504587 1.0 0.9954163487573698 99.22068115524993 GOTERM_BP_FAT GO:0007411~axon guidance 5 0.8169934640522877 0.2841090413648944 EPHA4, DPYSL5, APBB2, SLIT2, ETV4 375 98 13588 1.8487074829931975 1.0 0.9959658330027563 99.61832837612874 GOTERM_BP_FAT GO:0030182~neuron differentiation 13 2.1241830065359477 0.4173671083538524 RPGR, CCK, DPYSL5, NTNG1, RORB, SLIT2, EPHA4, PPP1R9A, SLC1A3, APBB2, CLN8, DST, ETV4 375 399 13588 1.1805781119465328 1.0 0.9982102460062876 99.98765801137816 GOTERM_BP_FAT GO:0030030~cell projection organization 10 1.6339869281045754 0.517204393807756 EPHA4, PPP1R9A, CCK, NTNG1, DPYSL5, MKKS, APBB2, DST, SLIT2, ETV4 375 319 13588 1.1358829676071056 1.0 0.9989872276698795 99.9994612739752 GOTERM_BP_FAT GO:0006928~cell motion 10 1.6339869281045754 0.6848931802094467 SGPL1, EPHA4, CCK, MET, DPYSL5, ITGA1, CLASP2, APBB2, SLIT2, ETV4 375 367 13588 0.9873206176203452 1.0 0.9996057907097896 99.99999955934088 Annotation Cluster 23 Enrichment Score: 0.7308622190921124 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015031~protein transport 26 4.248366013071895 0.05691204423073133 NUP160, MITD1, AP1S3, PPP1R3C, BLZF1, GNPTAB, BLOC1S3, STX16, SNF8, RANBP3, SEC22A, JAKMIP1, SCAMP2, ZDHHC3, STX3, 4930555K19RIK, ARNTL, VTI1A, RAB11FIP2, STXBP5, TOMM20, GOSR2, NUP107, VPS26B, ERC1, NUP43 375 651 13588 1.4471602662570404 1.0 0.9911808878082231 62.32708164312546 GOTERM_BP_FAT GO:0045184~establishment of protein localization 26 4.248366013071895 0.06244469871798268 NUP160, MITD1, AP1S3, PPP1R3C, BLZF1, GNPTAB, BLOC1S3, STX16, SNF8, RANBP3, SEC22A, JAKMIP1, SCAMP2, ZDHHC3, STX3, 4930555K19RIK, ARNTL, VTI1A, RAB11FIP2, STXBP5, TOMM20, GOSR2, NUP107, VPS26B, ERC1, NUP43 375 656 13588 1.436130081300813 1.0 0.9864382863384489 65.84479879026482 GOTERM_BP_FAT GO:0008104~protein localization 28 4.57516339869281 0.09665678862975485 NUP160, PPP3R1, MITD1, AP1S3, PPP1R3C, BLZF1, GNPTAB, BLOC1S3, STX16, SNF8, RANBP3, SEC22A, DLG1, JAKMIP1, SCAMP2, ZDHHC3, STX3, 4930555K19RIK, ARNTL, VTI1A, RAB11FIP2, STXBP5, TOMM20, GOSR2, NUP107, VPS26B, ERC1, NUP43 375 753 13588 1.347371403275786 1.0 0.9898098273283459 81.61390819758466 SP_PIR_KEYWORDS protein transport 19 3.104575163398693 0.1014625565255686 SCAMP2, NUP160, 4930555K19RIK, MITD1, VTI1A, AP1S3, BLZF1, STXBP5, STX16, SNF8, RANBP3, SEC22A, TOMM20, GOSR2, NUP107, VPS26B, ERC1, NUP43, JAKMIP1 503 461 17854 1.462918799567023 0.9999999999999988 0.805119979733429 76.41150916097381 GOTERM_BP_FAT GO:0046907~intracellular transport 17 2.7777777777777777 0.14047849324392578 ZDHHC3, STX3, NUP160, ARNTL, VTI1A, AP1S3, PPP1R3C, BLZF1, STX16, RANBP3, TOMM20, GOSR2, VPS26B, APBB2, STEAP2, ERC1, DST 375 431 13588 1.4292095901005413 1.0 0.9903839430218737 91.9704602855603 GOTERM_BP_FAT GO:0034613~cellular protein localization 11 1.7973856209150325 0.31456827843020335 AP1S3, BLZF1, PPP1R3C, STX3, ZDHHC3, STX16, PPP3R1, TOMM20, GOSR2, ARNTL, VTI1A 375 299 13588 1.3330479375696767 1.0 0.9965878334819963 99.81503192830047 GOTERM_BP_FAT GO:0070727~cellular macromolecule localization 11 1.7973856209150325 0.3166182286822743 AP1S3, BLZF1, PPP1R3C, STX3, ZDHHC3, STX16, PPP3R1, TOMM20, GOSR2, ARNTL, VTI1A 375 301 13588 1.3241904761904761 1.0 0.9965516752438163 99.82403562379018 GOTERM_BP_FAT GO:0006886~intracellular protein transport 10 1.6339869281045754 0.3479913681374916 AP1S3, BLZF1, PPP1R3C, STX3, ZDHHC3, STX16, TOMM20, GOSR2, ARNTL, VTI1A 375 276 13588 1.3128502415458938 1.0 0.99714284229813 99.91957610606286 SP_PIR_KEYWORDS transport 47 7.6797385620915035 0.4059480225414017 NUP160, GLRA2, CLCNKA, 4833423E24RIK, MITD1, ABCA3, SLC35A3, SLC7A6, AP1S3, BLZF1, SLC1A2, SLC1A3, MTCH2, SORBS1, STX16, SLC35F1, SNF8, SLC35B4, SEC22A, GRID2, RANBP3, SLC22A5, JAKMIP1, TRPC2, STX3, SCAMP2, SLC33A1, SLC6A14, 4930555K19RIK, VTI1A, KCNT1, STXBP5, ATP2A1, TOMM20, ATP6V0A1, CHRNB3, GOSR2, NUP107, CHRNB1, FABP2, SLC36A4, ERC1, STEAP2, TMCO3, VPS26B, NUP43, KCNH5 503 1571 17854 1.06191368656299 1.0 0.9573278735347722 99.91160173524908 GOTERM_BP_FAT GO:0006605~protein targeting 4 0.6535947712418301 0.7132475751346502 PPP1R3C, ZDHHC3, TOMM20, ARNTL 375 133 13588 1.0897644110275688 1.0 0.9997318397648022 99.99999990841015 Annotation Cluster 24 Enrichment Score: 0.7205662251079731 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043193~positive regulation of gene-specific transcription 4 0.6535947712418301 0.08086597368425524 RARG, NFKB1, TAF9, RORB 375 37 13588 3.917261261261261 1.0 0.9901443832046846 75.45988303801441 GOTERM_BP_FAT GO:0010552~positive regulation of specific transcription from RNA polymerase II promoter 3 0.49019607843137253 0.14045310438394681 RARG, NFKB1, TAF9 375 24 13588 4.529333333333334 1.0 0.9912454202766162 91.96650786484935 GOTERM_BP_FAT GO:0032583~regulation of gene-specific transcription 4 0.6535947712418301 0.2804898594143933 RARG, NFKB1, TAF9, RORB 375 67 13588 2.16326368159204 1.0 0.996109092352284 99.58487694096871 GOTERM_BP_FAT GO:0010551~regulation of specific transcription from RNA polymerase II promoter 3 0.49019607843137253 0.4116430353973778 RARG, NFKB1, TAF9 375 51 13588 2.131450980392157 1.0 0.99817740154719 99.98547475154048 Annotation Cluster 25 Enrichment Score: 0.6932451472568234 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000108:Neutrophil cytosol factor 2 4 0.6535947712418301 0.03204426436953725 SORBS1, SORBS2, ABI1, ITSN1 500 25 17763 5.68416 0.9999999999989538 0.802634623243522 39.56990843522321 UP_SEQ_FEATURE domain:SH3 3 3 0.49019607843137253 0.07894539918822487 SORBS1, SORBS2, ITSN1 444 17 16021 6.36764705882353 1.0 0.998411941982467 73.73056303835344 SP_PIR_KEYWORDS sh3 domain 9 1.4705882352941175 0.21659184377277516 SH3YL1, SORBS1, SORBS2, MYO1E, ABI1, ITSN1, DOCK5, DST, DLG1 503 204 17854 1.5659571979885394 1.0 0.900201770170102 96.29530988683842 UP_SEQ_FEATURE domain:SH3 1 3 0.49019607843137253 0.23156755712420993 SORBS1, SORBS2, ITSN1 444 33 16021 3.2803030303030307 1.0 0.9996158394072201 98.61804208074277 UP_SEQ_FEATURE domain:SH3 2 3 0.49019607843137253 0.24186307408676688 SORBS1, SORBS2, ITSN1 444 34 16021 3.183823529411765 1.0 0.9995543767461262 98.8901327813344 SMART SM00326:SH3 8 1.3071895424836601 0.3646589363781214 SH3YL1, SORBS1, SORBS2, MYO1E, ABI1, ITSN1, DOCK5, DLG1 253 211 9131 1.3683757001292545 1.0 0.9851823751172033 99.65235608647703 INTERPRO IPR001452:Src homology-3 domain 8 1.3071895424836601 0.38298094115326375 SH3YL1, SORBS1, SORBS2, MYO1E, ABI1, ITSN1, DOCK5, DLG1 500 211 17763 1.346957345971564 1.0 0.9987746950069004 99.94286034580867 UP_SEQ_FEATURE domain:SH3 5 0.8169934640522877 0.6637557355371081 SH3YL1, ABI1, DOCK5, DST, DLG1 444 163 16021 1.1068507157464211 1.0 0.9999995154096708 99.99999797852314 Annotation Cluster 26 Enrichment Score: 0.6783419980417565 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007189~activation of adenylate cyclase activity by G-protein signaling pathway 4 0.6535947712418301 0.05698251104741234 GNAL, CALCRL, TSHR, GCGR 375 32 13588 4.529333333333333 1.0 0.9888912650629665 62.3739514601209 GOTERM_BP_FAT GO:0010579~positive regulation of adenylate cyclase activity by G-protein signaling pathway 4 0.6535947712418301 0.05698251104741234 GNAL, CALCRL, TSHR, GCGR 375 32 13588 4.529333333333333 1.0 0.9888912650629665 62.3739514601209 GOTERM_BP_FAT GO:0010578~regulation of adenylate cyclase activity involved in G-protein signaling 4 0.6535947712418301 0.05698251104741234 GNAL, CALCRL, TSHR, GCGR 375 32 13588 4.529333333333333 1.0 0.9888912650629665 62.3739514601209 GOTERM_BP_FAT GO:0007190~activation of adenylate cyclase activity 4 0.6535947712418301 0.10257090958378234 GNAL, CALCRL, TSHR, GCGR 375 41 13588 3.535089430894309 1.0 0.9900623458168808 83.51977080401484 GOTERM_BP_FAT GO:0051349~positive regulation of lyase activity 4 0.6535947712418301 0.1083241412407251 GNAL, CALCRL, TSHR, GCGR 375 42 13588 3.4509206349206347 1.0 0.9889978977746952 85.19431554686177 GOTERM_BP_FAT GO:0045762~positive regulation of adenylate cyclase activity 4 0.6535947712418301 0.1083241412407251 GNAL, CALCRL, TSHR, GCGR 375 42 13588 3.4509206349206347 1.0 0.9889978977746952 85.19431554686177 GOTERM_BP_FAT GO:0031281~positive regulation of cyclase activity 4 0.6535947712418301 0.1083241412407251 GNAL, CALCRL, TSHR, GCGR 375 42 13588 3.4509206349206347 1.0 0.9889978977746952 85.19431554686177 GOTERM_BP_FAT GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger 4 0.6535947712418301 0.19262506210146396 GNAL, CALCRL, TSHR, GCGR 375 55 13588 2.6352484848484847 1.0 0.9945379404369856 97.16967660332858 GOTERM_BP_FAT GO:0045761~regulation of adenylate cyclase activity 4 0.6535947712418301 0.22849885701672212 GNAL, CALCRL, TSHR, GCGR 375 60 13588 2.4156444444444443 1.0 0.9953813226485806 98.67266226005567 GOTERM_BP_FAT GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger 4 0.6535947712418301 0.22849885701672212 GNAL, CALCRL, TSHR, GCGR 375 60 13588 2.4156444444444443 1.0 0.9953813226485806 98.67266226005567 GOTERM_BP_FAT GO:0019933~cAMP-mediated signaling 4 0.6535947712418301 0.23582319289333195 GNAL, CALCRL, TSHR, GCGR 375 61 13588 2.3760437158469947 1.0 0.9952904563055991 98.86769866014748 GOTERM_BP_FAT GO:0051339~regulation of lyase activity 4 0.6535947712418301 0.24318811995207965 GNAL, CALCRL, TSHR, GCGR 375 62 13588 2.3377204301075265 1.0 0.994892119185438 99.03641547443337 GOTERM_BP_FAT GO:0031279~regulation of cyclase activity 4 0.6535947712418301 0.24318811995207965 GNAL, CALCRL, TSHR, GCGR 375 62 13588 2.3377204301075265 1.0 0.994892119185438 99.03641547443337 GOTERM_BP_FAT GO:0030817~regulation of cAMP biosynthetic process 4 0.6535947712418301 0.265488434567497 GNAL, CALCRL, TSHR, GCGR 375 65 13588 2.229825641025641 1.0 0.9959281697205132 99.41455951602185 GOTERM_BP_FAT GO:0019935~cyclic-nucleotide-mediated signaling 4 0.6535947712418301 0.2729780779338749 GNAL, CALCRL, TSHR, GCGR 375 66 13588 2.1960404040404042 1.0 0.9961405865548467 99.5064569063147 GOTERM_BP_FAT GO:0030814~regulation of cAMP metabolic process 4 0.6535947712418301 0.2804898594143933 GNAL, CALCRL, TSHR, GCGR 375 67 13588 2.16326368159204 1.0 0.996109092352284 99.58487694096871 GOTERM_BP_FAT GO:0030802~regulation of cyclic nucleotide biosynthetic process 4 0.6535947712418301 0.3031238019141429 GNAL, CALCRL, TSHR, GCGR 375 70 13588 2.070552380952381 1.0 0.9964932444318907 99.75627002088935 GOTERM_BP_FAT GO:0030808~regulation of nucleotide biosynthetic process 4 0.6535947712418301 0.3031238019141429 GNAL, CALCRL, TSHR, GCGR 375 70 13588 2.070552380952381 1.0 0.9964932444318907 99.75627002088935 GOTERM_BP_FAT GO:0030799~regulation of cyclic nucleotide metabolic process 4 0.6535947712418301 0.32583711086572 GNAL, CALCRL, TSHR, GCGR 375 73 13588 1.9854611872146117 1.0 0.9968498162745051 99.85966934839747 GOTERM_BP_FAT GO:0006140~regulation of nucleotide metabolic process 4 0.6535947712418301 0.34098232675545254 GNAL, CALCRL, TSHR, GCGR 375 75 13588 1.9325155555555555 1.0 0.9970184835993288 99.90389382375972 GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 9 1.4705882352941175 0.4289472590961948 SERINC2, GNAL, GSPT1, DGKG, MET, CALCRL, TSHR, GCGR, DLG1 375 261 13588 1.249471264367816 1.0 0.9981992604736588 99.9911666233421 KEGG_PATHWAY mmu04080:Neuroactive ligand-receptor interaction 8 1.3071895424836601 0.45057570370809374 GPR156, GRM5, GLRA2, FPR1, GRID2, CALCRL, TSHR, GCGR 141 260 5738 1.2521549372613203 1.0 0.9981919511239099 99.89219139908556 GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 9 1.4705882352941175 0.6090201742638526 SERINC2, GNAL, GSPT1, DGKG, MET, CALCRL, TSHR, GCGR, DLG1 375 306 13588 1.0657254901960784 1.0 0.9992555700205538 99.99998396291713 GOTERM_BP_FAT GO:0019932~second-messenger-mediated signaling 4 0.6535947712418301 0.6346713006057102 GNAL, CALCRL, TSHR, GCGR 375 118 13588 1.2282937853107345 1.0 0.9994046217616452 99.99999482233584 Annotation Cluster 27 Enrichment Score: 0.6330114216480397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044431~Golgi apparatus part 10 1.6339869281045754 0.13803523625788733 TRPC2, AP1S3, BLZF1, SCAMP2, GOSR2, VAMP2, STEAP2, SLC35A3, ZFYVE1, B4GALNT1 326 227 12504 1.6896840625929028 1.0 0.8742065636498009 86.53968294435145 GOTERM_CC_FAT GO:0000139~Golgi membrane 7 1.1437908496732025 0.14684757363094653 TRPC2, AP1S3, SCAMP2, GOSR2, STEAP2, SLC35A3, B4GALNT1 326 137 12504 1.9597868434015495 1.0 0.8804688274995581 88.28337037840292 GOTERM_CC_FAT GO:0012505~endomembrane system 18 2.941176470588235 0.23155315798661752 TRPC2, SYT1, SCAMP2, NUP160, ITSN1, SLC35A3, AP1S3, STT3A, H13, ATP2A1, GOSR2, VAMP2, NUP107, STEAP2, VPS26B, NUP43, DLG1, B4GALNT1 326 535 12504 1.290476463505533 1.0 0.9228502487988158 97.14443205470559 GOTERM_CC_FAT GO:0031090~organelle membrane 21 3.431372549019608 0.6258162948956748 TRPC2, SYT1, SCAMP2, COX10, BCKDHB, SLC35A3, HADHA, AP1S3, STT3A, H13, MTCH2, TOMM70A, ATP2A1, ZFYVE28, TOMM20, GOSR2, VAMP2, STEAP2, B4GALNT1, DLG1, ABCA12 326 809 12504 0.9956395459061024 1.0 0.9889772693777092 99.99982769648048 Annotation Cluster 28 Enrichment Score: 0.6214630887670303 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C2H2-type 9 7 1.1437908496732025 0.058865951508782904 ZFP82, ZFP553, ZFP770, ZSCAN20, ZIK1, ZFP28, ZKSCAN5 444 100 16021 2.5258333333333334 1.0 0.993730048198612 62.70084630091376 UP_SEQ_FEATURE zinc finger region:C2H2-type 10 6 0.9803921568627451 0.10390285316681143 ZFP82, ZFP553, ZFP770, ZSCAN20, ZFP28, ZKSCAN5 444 90 16021 2.405555555555556 1.0 0.9995205555974742 83.19179432135735 UP_SEQ_FEATURE zinc finger region:C2H2-type 8 7 1.1437908496732025 0.10904141424273527 ZFP82, ZFP553, ZFP770, ZSCAN20, ZIK1, ZFP28, ZKSCAN5 444 118 16021 2.1405367231638417 1.0 0.9986136321282796 84.69185122651497 UP_SEQ_FEATURE zinc finger region:C2H2-type 11 5 0.8169934640522877 0.13824527290580843 ZFP82, ZFP553, ZFP770, ZFP28, ZKSCAN5 444 72 16021 2.5057870370370368 1.0 0.9992352756651958 91.09472972308828 UP_SEQ_FEATURE domain:KRAB 4 0.6535947712418301 0.14025321396313972 ZFP82, ZIK1, ZFP28, ZKSCAN5 444 47 16021 3.0709219858156027 1.0 0.9991048884399981 91.42609397475393 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 7 1.1437908496732025 0.24026955408328057 ZFP82, ZFP553, ZFP770, ZSCAN20, ZIK1, ZFP28, ZKSCAN5 444 151 16021 1.6727373068432672 1.0 0.9996029944008131 98.8515982264611 UP_SEQ_FEATURE zinc finger region:C2H2-type 12 4 0.6535947712418301 0.2677505929679076 ZFP82, ZFP553, ZFP28, ZKSCAN5 444 65 16021 2.2205128205128206 1.0 0.9997087827315878 99.3690396132663 UP_SEQ_FEATURE zinc finger region:C2H2-type 7 6 0.9803921568627451 0.28037960001024953 ZFP82, ZFP553, ZSCAN20, ZIK1, ZFP28, ZKSCAN5 444 128 16021 1.6914062500000002 1.0 0.9997392916530891 99.52446254368733 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 8 1.3071895424836601 0.3412958944344825 ZFP82, ZFP553, ZFP770, ZSCAN20, YY1, ZIK1, ZFP28, ZKSCAN5 444 206 16021 1.401294498381877 1.0 0.9998375840264796 99.88707990849885 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 8 1.3071895424836601 0.5486932337218682 ZFP82, ZFP553, ZFP770, ZSCAN20, YY1, ZIK1, ZFP28, ZKSCAN5 444 252 16021 1.1455026455026454 1.0 0.9999939798021622 99.99975825239405 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 8 1.3071895424836601 0.5571046853682146 ZFP82, ZFP553, ZFP770, YY1, ZIK1, ZBTB3, ZFP28, ZKSCAN5 444 254 16021 1.136482939632546 1.0 0.999994754577231 99.99982194890032 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 8 1.3071895424836601 0.5778244426111294 ZFP82, ZFP553, ZFP770, YY1, ZIK1, ZBTB3, ZFP28, ZKSCAN5 444 259 16021 1.1145431145431144 1.0 0.9999960011527252 99.99991828421898 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 6 0.9803921568627451 0.5928770402572634 ZFP553, ZFP770, ZSCAN20, ZIK1, ZFP28, ZKSCAN5 444 187 16021 1.1577540106951871 1.0 0.9999972547005002 99.99995471005036 Annotation Cluster 29 Enrichment Score: 0.621346954741159 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005694~chromosome 19 3.104575163398693 0.010005673487729273 HMGN3, NUP160, SMC5, SMC6, NUFIP1, CHEK1, POT1B, PURB, CHD9, TRIM66, RNF2, SUPT16H, PBRM1, RAD18, SETD8, NUP107, CLASP2, NUP43, HELLS 326 378 12504 1.9279384555458174 0.9603632039772602 0.4756518883017359 12.695238447612578 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 50 8.169934640522875 0.5786481034949075 HMGN3, PDLIM7, RPL13, DEDD, TTLL4, POT1B, 2310008H09RIK, KIFC3, DHX33, MRPL38, CIRH1A, JAKMIP1, DLG1, KRR1, POLR1E, CTNNA1, TCTE3, PURB, CNTROB, RAD18, NUP107, DST, NUP43, NUP160, 2610029G23RIK, LRRCC1, NUFIP1, ABI1, CHEK1, CORO2B, CHD9, TRIM66, SORBS1, KIF7, CEP170, PBRM1, CLASP2, HELLS, MYO1E, SMC5, SMC6, SMEK1, WRN, PEO1, PPP1R9A, RNF2, SUPT16H, TMOD3, SETD8, PARP2 326 1919 12504 0.9993701985632854 1.0 0.9868973288127403 99.99914414986952 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 50 8.169934640522875 0.5786481034949075 HMGN3, PDLIM7, RPL13, DEDD, TTLL4, POT1B, 2310008H09RIK, KIFC3, DHX33, MRPL38, CIRH1A, JAKMIP1, DLG1, KRR1, POLR1E, CTNNA1, TCTE3, PURB, CNTROB, RAD18, NUP107, DST, NUP43, NUP160, 2610029G23RIK, LRRCC1, NUFIP1, ABI1, CHEK1, CORO2B, CHD9, TRIM66, SORBS1, KIF7, CEP170, PBRM1, CLASP2, HELLS, MYO1E, SMC5, SMC6, SMEK1, WRN, PEO1, PPP1R9A, RNF2, SUPT16H, TMOD3, SETD8, PARP2 326 1919 12504 0.9993701985632854 1.0 0.9868973288127403 99.99914414986952 GOTERM_CC_FAT GO:0005856~cytoskeleton 21 3.431372549019608 0.9761954662307184 PDLIM7, MYO1E, LRRCC1, TTLL4, ABI1, CHEK1, SMEK1, CTNNA1, TCTE3, KIFC3, CORO2B, PPP1R9A, KIF7, SORBS1, CEP170, CNTROB, TMOD3, CLASP2, DST, DLG1, JAKMIP1 326 1122 12504 0.717889833010728 1.0 0.9999797942353347 100.0 Annotation Cluster 30 Enrichment Score: 0.6146386188605232 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00008:HormR 3 0.49019607843137253 0.17019204037352811 LPHN3, CALCRL, GCGR 253 27 9131 4.0101010101010095 0.9999999999999999 0.9517623724171228 90.25730167382488 INTERPRO IPR001879:GPCR, family 2, extracellular region 3 0.49019607843137253 0.17503258397429178 LPHN3, CALCRL, GCGR 500 27 17763 3.9473333333333334 1.0 0.993859744692527 94.89867350446592 INTERPRO IPR017981:GPCR, family 2-like 4 0.6535947712418301 0.22267382865692353 LPHN3, CALCRL, FZD5, GCGR 500 58 17763 2.450068965517241 1.0 0.9937793894268793 97.96687410146157 PIR_SUPERFAMILY PIRSF800007:secretin receptor-like G protein-coupled receptors 3 0.49019607843137253 0.24309827896834346 LPHN3, CALCRL, GCGR 203 38 8136 3.1641171895255376 1.0 0.9999837832466199 96.93535197724844 INTERPRO IPR000832:GPCR, family 2, secretin-like 3 0.49019607843137253 0.35165213913562465 LPHN3, CALCRL, GCGR 500 44 17763 2.4222272727272727 1.0 0.9985757138714854 99.87709058690196 INTERPRO IPR017983:GPCR, family 2, secretin-like, conserved site 3 0.49019607843137253 0.3618643614926492 LPHN3, CALCRL, GCGR 500 45 17763 2.3684000000000003 1.0 0.9987379527136354 99.90384946407788 Annotation Cluster 31 Enrichment Score: 0.6125527831698865 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:Kelch 6 4 0.6535947712418301 0.12145646248566674 KLHL13, KLHL24, KLHDC8B, KLHDC2 444 44 16021 3.2803030303030303 1.0 0.9988475241799022 87.81404373341914 UP_SEQ_FEATURE repeat:Kelch 5 4 0.6535947712418301 0.17351855358932633 KLHL13, KLHL24, KLHDC8B, KLHDC2 444 52 16021 2.7756410256410255 1.0 0.9991141456969063 95.48554239638312 UP_SEQ_FEATURE repeat:Kelch 4 4 0.6535947712418301 0.1944429316429442 KLHL13, KLHL24, KLHDC8B, KLHDC2 444 55 16021 2.6242424242424245 1.0 0.9994641767432444 97.02440062356462 UP_SEQ_FEATURE repeat:Kelch 3 4 0.6535947712418301 0.20872164072676813 KLHL13, KLHL24, KLHDC8B, KLHDC2 444 57 16021 2.5321637426900585 1.0 0.9993504341424619 97.77505268256523 UP_SEQ_FEATURE repeat:Kelch 2 4 0.6535947712418301 0.20872164072676813 KLHL13, KLHL24, KLHDC8B, KLHDC2 444 57 16021 2.5321637426900585 1.0 0.9993504341424619 97.77505268256523 UP_SEQ_FEATURE repeat:Kelch 1 4 0.6535947712418301 0.20872164072676813 KLHL13, KLHL24, KLHDC8B, KLHDC2 444 57 16021 2.5321637426900585 1.0 0.9993504341424619 97.77505268256523 SMART SM00612:Kelch 4 0.6535947712418301 0.281783991513217 KLHL13, KLHL24, KLHDC8B, KLHDC2 253 67 9131 2.1546811397557666 1.0 0.9775528492536573 98.39388176093891 INTERPRO IPR015915:Kelch-type beta propeller 4 0.6535947712418301 0.29091749587468163 KLHL13, KLHL24, KLHDC8B, KLHDC2 500 67 17763 2.120955223880597 1.0 0.9973746511485669 99.5090873262912 INTERPRO IPR006652:Kelch repeat type 1 4 0.6535947712418301 0.29091749587468163 KLHL13, KLHL24, KLHDC8B, KLHDC2 500 67 17763 2.120955223880597 1.0 0.9973746511485669 99.5090873262912 SP_PIR_KEYWORDS kelch repeat 4 0.6535947712418301 0.299085598078493 KLHL13, KLHL24, KLHDC8B, KLHDC2 503 68 17854 2.0879429306513857 1.0 0.9338637573478504 99.17519712076773 INTERPRO IPR013089:Kelch related 3 0.49019607843137253 0.6877122164766778 KLHL13, KLHL24, KLHDC8B 500 84 17763 1.2687857142857142 1.0 0.999989481485011 99.99999847517186 Annotation Cluster 32 Enrichment Score: 0.5768680812896044 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018359:Bromodomain, conserved site 3 0.49019607843137253 0.22653100727918024 PHIP, TRIM66, PBRM1 500 32 17763 3.3305625 1.0 0.9928792460156729 98.11741905139357 SP_PIR_KEYWORDS bromodomain 3 0.49019607843137253 0.2477668361474198 PHIP, TRIM66, PBRM1 503 34 17854 3.1319143959770788 1.0 0.9039967872939048 97.85880316029123 SMART SM00297:BROMO 3 0.49019607843137253 0.2927070299241523 PHIP, TRIM66, PBRM1 253 39 9131 2.776223776223776 1.0 0.9713968215884098 98.67352017735026 INTERPRO IPR001487:Bromodomain 3 0.49019607843137253 0.29986355858263547 PHIP, TRIM66, PBRM1 500 39 17763 2.732769230769231 1.0 0.9973157789258812 99.59660723590133 Annotation Cluster 33 Enrichment Score: 0.5739642731410984 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000278~mitotic cell cycle 12 1.9607843137254901 0.07482319273391702 DCLRE1A, PPM1D, NEK1, RNF2, LRRCC1, TPD52L1, SETD8, CHEK1, CLASP2, NUP43, 6720463M24RIK, HELLS 375 244 13588 1.7820327868852461 1.0 0.9879478453443126 72.62901872351537 GOTERM_BP_FAT GO:0022402~cell cycle process 16 2.6143790849673203 0.12508624516559216 NEK1, LRRCC1, DBC1, TPD52L1, CHEK1, ZFP318, 6720463M24RIK, PPM1D, DCLRE1A, CNTROB, SETD8, CLASP2, APBB2, DST, NUP43, HELLS 375 393 13588 1.475202714164546 1.0 0.9914955970200247 89.2076172813253 GOTERM_BP_FAT GO:0048285~organelle fission 9 1.4705882352941175 0.17681163806151695 DCLRE1A, COX10, NEK1, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 375 197 13588 1.6553908629441623 1.0 0.9936469866534711 96.0899471567318 SP_PIR_KEYWORDS mitosis 8 1.3071895424836601 0.23984632853597534 DCLRE1A, NEK1, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 503 179 17854 1.586370047869209 1.0 0.9013878958412389 97.5335587497967 GOTERM_BP_FAT GO:0007067~mitosis 8 1.3071895424836601 0.2693957170046902 DCLRE1A, NEK1, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 375 190 13588 1.5256701754385964 1.0 0.9960516128997813 99.4643388202935 GOTERM_BP_FAT GO:0000280~nuclear division 8 1.3071895424836601 0.2693957170046902 DCLRE1A, NEK1, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 375 190 13588 1.5256701754385964 1.0 0.9960516128997813 99.4643388202935 GOTERM_BP_FAT GO:0000087~M phase of mitotic cell cycle 8 1.3071895424836601 0.2862515278876757 DCLRE1A, NEK1, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 375 194 13588 1.494213058419244 1.0 0.995926364478299 99.63691922405569 GOTERM_BP_FAT GO:0022403~cell cycle phase 12 1.9607843137254901 0.2940087032326669 DCLRE1A, PPM1D, NEK1, LRRCC1, TPD52L1, SETD8, CHEK1, CLASP2, ZFP318, NUP43, 6720463M24RIK, HELLS 375 328 13588 1.325658536585366 1.0 0.9959369945116869 99.69735356976068 GOTERM_BP_FAT GO:0007049~cell cycle 20 3.2679738562091507 0.32597532552410075 E2F3, NEK1, LRRCC1, DBC1, CDC73, TPD52L1, CHEK1, ZFP318, 6720463M24RIK, PPM1D, DCLRE1A, RNF2, CNTROB, SETD8, TLK2, CLASP2, APBB2, NUP43, DST, HELLS 375 611 13588 1.1860774686306603 1.0 0.9966837456654771 99.86014790176041 SP_PIR_KEYWORDS cell cycle 15 2.450980392156863 0.3782425988524705 E2F3, NEK1, LRRCC1, DBC1, CDC73, CHEK1, 6720463M24RIK, PPM1D, DCLRE1A, CNTROB, SETD8, TLK2, CLASP2, NUP43, HELLS 503 447 17854 1.191108383257502 1.0 0.9526797983614002 99.83642646695905 SP_PIR_KEYWORDS cell division 9 1.4705882352941175 0.43501698654118537 DCLRE1A, NEK1, CNTROB, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 503 256 17854 1.2478721421471173 1.0 0.9575728220968935 99.95509718694422 GOTERM_BP_FAT GO:0051301~cell division 9 1.4705882352941175 0.5113669641552046 DCLRE1A, NEK1, CNTROB, LRRCC1, SETD8, CLASP2, NUP43, 6720463M24RIK, HELLS 375 281 13588 1.1605409252669039 1.0 0.9990014521126604 99.99934184644827 GOTERM_BP_FAT GO:0000279~M phase 9 1.4705882352941175 0.5196265239058792 DCLRE1A, NEK1, LRRCC1, SETD8, CLASP2, ZFP318, NUP43, 6720463M24RIK, HELLS 375 283 13588 1.152339222614841 1.0 0.9989490092836327 99.99950457626743 Annotation Cluster 34 Enrichment Score: 0.5692071395311232 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0040014~regulation of multicellular organism growth 5 0.8169934640522877 0.1517085798623654 SGPL1, ATXN2, AGT, TSHR, DLG1 375 75 13588 2.4156444444444447 1.0 0.9898361752700948 93.55041391827473 GOTERM_BP_FAT GO:0001655~urogenital system development 7 1.1437908496732025 0.21473358615270177 SGPL1, RARG, AGT, MYO1E, HELLS, SLIT2, DLG1 375 146 13588 1.7372785388127854 1.0 0.9946076727436637 98.21786396324181 GOTERM_BP_FAT GO:0001822~kidney development 5 0.8169934640522877 0.34020715493524006 SGPL1, AGT, MYO1E, SLIT2, DLG1 375 107 13588 1.6932087227414332 1.0 0.9971262304736535 99.90199299771 GOTERM_BP_FAT GO:0001656~metanephros development 3 0.49019607843137253 0.4769994505272435 AGT, SLIT2, DLG1 375 58 13588 1.8742068965517242 1.0 0.9985575724209891 99.99795764557176 Annotation Cluster 35 Enrichment Score: 0.5655593988224533 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 7 1.1437908496732025 0.1344391102925052 POLR1E, HELB, NFAT5, ATP6V0A1, TCEB3, TAF9, LCOR 375 126 13588 2.013037037037037 1.0 0.991015349332477 90.97695976313823 GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 6 0.9803921568627451 0.24579459920030983 POLR1E, NFAT5, ATP6V0A1, TCEB3, TAF9, LCOR 375 122 13588 1.7820327868852461 1.0 0.9948930710733427 99.09023864902107 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 3 0.49019607843137253 0.6084485183384896 ATP6V0A1, TCEB3, LCOR 375 74 13588 1.468972972972973 1.0 0.9992739013586127 99.9999835677594 Annotation Cluster 36 Enrichment Score: 0.5470488946943646 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00280:Valine, leucine and isoleucine degradation 5 0.8169934640522877 0.025094206941169026 ACADSB, ACADS, IVD, BCKDHB, HADHA 141 46 5738 4.423373419673142 0.9475594157126284 0.6256976900523807 25.169821756165334 KEGG_PATHWAY mmu00071:Fatty acid metabolism 3 0.49019607843137253 0.30075236480642353 ACADSB, ACADS, HADHA 141 45 5738 2.7130023640661936 1.0 0.9973373516215782 98.31180810819666 SP_PIR_KEYWORDS fatty acid metabolism 3 0.49019607843137253 0.5149562100267127 ACADSB, ACADS, HADHA 503 61 17854 1.745657204315093 1.0 0.9703685573791115 99.99427488763976 SP_PIR_KEYWORDS lipid metabolism 5 0.8169934640522877 0.5344156340027387 SGPL1, ACADSB, ACADS, PNPLA2, HADHA 503 136 17854 1.3049643316571162 1.0 0.9729132375496863 99.99670614249462 GOTERM_BP_FAT GO:0006631~fatty acid metabolic process 4 0.6535947712418301 0.8857752598632473 ACADSB, ACADS, 4833423E24RIK, HADHA 375 184 13588 0.7877101449275362 1.0 0.9999782513338761 99.99999999999997 Annotation Cluster 37 Enrichment Score: 0.5282499232313277 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 10 1.6339869281045754 0.25552509800337575 ERCC8, SLC1A2, SLC1A3, TSC22D2, AGT, NEK1, ADAM2, MKKS, RAD18, FOXP2 375 251 13588 1.4436122177954847 1.0 0.9954318745374408 99.26722636135946 GOTERM_BP_FAT GO:0009416~response to light stimulus 5 0.8169934640522877 0.2841090413648944 ERCC8, SLC1A2, SLC1A3, ADAM2, RAD18 375 98 13588 1.8487074829931975 1.0 0.9959658330027563 99.61832837612874 GOTERM_BP_FAT GO:0009314~response to radiation 6 0.9803921568627451 0.3583699713988381 ERCC8, SLC1A2, SLC1A3, NEK1, ADAM2, RAD18 375 143 13588 1.5203356643356642 1.0 0.9973125201149633 99.93844202706802 Annotation Cluster 38 Enrichment Score: 0.5164116704510742 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Sushi 3 3 0.49019607843137253 0.14151510798506567 SVEP1, RPGR, CFH 444 24 16021 4.510416666666667 1.0 0.9989231140895282 91.62838127076584 UP_SEQ_FEATURE domain:Sushi 1 3 0.49019607843137253 0.23156755712420993 SVEP1, RPGR, CFH 444 33 16021 3.2803030303030307 1.0 0.9996158394072201 98.61804208074277 UP_SEQ_FEATURE domain:Sushi 2 3 0.49019607843137253 0.23156755712420993 SVEP1, RPGR, CFH 444 33 16021 3.2803030303030307 1.0 0.9996158394072201 98.61804208074277 SP_PIR_KEYWORDS sushi 3 0.49019607843137253 0.37242793678282526 SVEP1, RPGR, CFH 503 46 17854 2.3148932492004497 1.0 0.95565186699832 99.8145221779808 SMART SM00032:CCP 3 0.49019607843137253 0.43224296578732657 SVEP1, RPGR, CFH 253 53 9131 2.0428816466552315 1.0 0.9879088479071255 99.91459971025924 INTERPRO IPR000436:Sushi/SCR/CCP 3 0.49019607843137253 0.4410182969734523 SVEP1, RPGR, CFH 500 53 17763 2.0109056603773587 1.0 0.999489028919924 99.9875986852174 INTERPRO IPR016060:Complement control module 3 0.49019607843137253 0.450539920476969 SVEP1, RPGR, CFH 500 54 17763 1.9736666666666667 1.0 0.9994843831722294 99.99049230204726 Annotation Cluster 39 Enrichment Score: 0.5054957338094973 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005085~guanyl-nucleotide exchange factor activity 10 1.6339869281045754 0.02083195165689023 ARHGEF3, ABR, RPGR, RAPGEF6, DOCK8, ITSN1, DOCK5, DOCK6, ARHGEF10, BCAR3 368 147 13288 2.456373853889382 0.9999720164876609 0.8771485053040005 26.13910592436056 SP_PIR_KEYWORDS guanine-nucleotide releasing factor 8 1.3071895424836601 0.024969285475710465 ARHGEF3, ABR, RPGR, DOCK8, DOCK5, DOCK6, ARHGEF10, BCAR3 503 102 17854 2.783923907535181 0.9997015488695954 0.5941932677879238 28.921548084449878 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 15 2.450980392156863 0.12259414911505678 ARHGEF3, TNIK, RPGR, ABR, ARHGAP19, DOCK8, DOCK5, ITSN1, DOCK6, ARHGEF10, RAPGEF6, ERC1, TBC1D8B, RASA2, BCAR3 368 361 13288 1.5003613151872817 1.0 0.948207550055871 84.77613462630875 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 15 2.450980392156863 0.1344279167884263 ARHGEF3, TNIK, RPGR, ABR, ARHGAP19, DOCK8, DOCK5, ITSN1, DOCK6, ARHGEF10, RAPGEF6, ERC1, TBC1D8B, RASA2, BCAR3 368 367 13288 1.4758322473640564 1.0 0.9370325765764972 87.4786995229684 SMART SM00239:C2 7 1.1437908496732025 0.15005080036615037 SYT1, RAB11FIP2, ABR, UVRAG, PKN2, ITSN1, RASA2 253 130 9131 1.9433566433566432 0.9999999999999829 0.9704756054199771 86.85732329360133 INTERPRO IPR000008:C2 calcium-dependent membrane targeting 7 1.1437908496732025 0.15967447695674286 SYT1, RAB11FIP2, ABR, UVRAG, PKN2, ITSN1, RASA2 500 130 17763 1.9129384615384617 1.0 0.9948175093984127 93.21467503750374 INTERPRO IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site 4 0.6535947712418301 0.1863080918163982 ARHGEF3, ABR, ITSN1, ARHGEF10 500 53 17763 2.6812075471698114 1.0 0.9949672356782402 95.87664162957559 UP_SEQ_FEATURE domain:DH 4 0.6535947712418301 0.20155222808795478 ARHGEF3, ABR, ITSN1, ARHGEF10 444 56 16021 2.577380952380952 1.0 0.9992808004146841 97.42370788334667 SMART SM00325:RhoGEF 4 0.6535947712418301 0.2667185315110414 ARHGEF3, ABR, ITSN1, ARHGEF10 253 65 9131 2.2209790209790206 1.0 0.9822777350425749 97.91881594087842 INTERPRO IPR000219:Dbl homology (DH) domain 4 0.6535947712418301 0.27555572451540894 ARHGEF3, ABR, ITSN1, ARHGEF10 500 65 17763 2.1862153846153847 1.0 0.9970000700576185 99.31615587338533 GOTERM_MF_FAT GO:0005089~Rho guanyl-nucleotide exchange factor activity 4 0.6535947712418301 0.3125363785112343 ARHGEF3, ABR, ITSN1, ARHGEF10 368 71 13288 2.03429271279853 1.0 0.9760664441861071 99.54537933274212 INTERPRO IPR018029:C2 membrane targeting protein 5 0.8169934640522877 0.3476645050540853 SYT1, RAB11FIP2, ABR, ITSN1, RASA2 500 106 17763 1.6757547169811322 1.0 0.9986105159858454 99.86486504464605 GOTERM_MF_FAT GO:0005088~Ras guanyl-nucleotide exchange factor activity 4 0.6535947712418301 0.403238438903622 ARHGEF3, ABR, ITSN1, ARHGEF10 368 83 13288 1.7401781037192248 1.0 0.9852207372386653 99.94067217053838 GOTERM_BP_FAT GO:0035023~regulation of Rho protein signal transduction 4 0.6535947712418301 0.42329622970861125 ARHGEF3, ABR, ITSN1, ARHGEF10 375 86 13588 1.6853333333333333 1.0 0.9981658086807889 99.9895917874595 GOTERM_BP_FAT GO:0051056~regulation of small GTPase mediated signal transduction 8 1.3071895424836601 0.43871118863529834 ARHGEF3, ABR, RAPGEF6, SHOC2, ITSN1, TBC1D8B, ARHGEF10, RASA2 375 228 13588 1.2713918128654969 1.0 0.9982938069671036 99.99337260211847 GOTERM_BP_FAT GO:0046578~regulation of Ras protein signal transduction 6 0.9803921568627451 0.5598841879945083 ARHGEF3, ABR, SHOC2, ITSN1, TBC1D8B, ARHGEF10 375 181 13588 1.2011491712707183 1.0 0.9991854574895466 99.99988473947113 UP_SEQ_FEATURE domain:C2 3 0.49019607843137253 0.5646900925552898 ABR, PKN2, ITSN1 444 68 16021 1.5919117647058825 1.0 0.9999953095309032 99.99986554118522 GOTERM_MF_FAT GO:0005083~small GTPase regulator activity 7 1.1437908496732025 0.5835681351638169 ARHGEF3, ABR, TNIK, ITSN1, ERC1, TBC1D8B, ARHGEF10 368 223 13288 1.1334568141938 1.0 0.9970230478571129 99.99966552592326 SP_PIR_KEYWORDS GTPase activation 4 0.6535947712418301 0.7401946954699904 ABR, ARHGAP19, TBC1D8B, RASA2 503 136 17854 1.0439714653256928 1.0 0.9926752029450816 99.9999987489747 UP_SEQ_FEATURE domain:PH 5 0.8169934640522877 0.8135157070166894 ARHGEF3, ABR, BMX, ITSN1, RASA2 444 202 16021 0.8931518151815181 1.0 0.9999999983944318 99.99999999986065 GOTERM_MF_FAT GO:0008047~enzyme activator activity 6 0.9803921568627451 0.821949504900038 ABR, ARHGAP19, ABI1, ITSN1, TBC1D8B, RASA2 368 249 13288 0.8700890518596123 1.0 0.999595419819246 99.99999999836471 INTERPRO IPR011993:Pleckstrin homology-type 7 1.1437908496732025 0.8254887287790653 ARHGEF3, PLEKHA5, RANBP3, BMX, APBB2, ITSN1, RASA2 500 289 17763 0.860491349480969 1.0 0.9999996738790637 99.99999999981178 SMART SM00233:PH 6 0.9803921568627451 0.8522963230742429 ARHGEF3, PLEKHA5, ABR, BMX, ITSN1, RASA2 253 261 9131 0.8296760710553813 1.0 0.9998608117752958 99.99999999571104 INTERPRO IPR001849:Pleckstrin homology 6 0.9803921568627451 0.8608405632171473 ARHGEF3, PLEKHA5, ABR, BMX, ITSN1, RASA2 500 261 17763 0.8166896551724138 1.0 0.9999998941795823 99.99999999999432 GOTERM_MF_FAT GO:0005096~GTPase activator activity 4 0.6535947712418301 0.9035000069044188 ABR, ARHGAP19, TBC1D8B, RASA2 368 192 13288 0.7522644927536232 1.0 0.9999226297723758 99.99999999999976 Annotation Cluster 40 Enrichment Score: 0.504950595382964 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000776~kinetochore 5 0.8169934640522877 0.07735996898945362 NUP160, PBRM1, NUP107, CLASP2, NUP43 326 62 12504 3.0932119532950724 0.9999999999940383 0.8421515046299839 66.27847829368294 GOTERM_CC_FAT GO:0000775~chromosome, centromeric region 6 0.9803921568627451 0.16259462646337905 NUP160, PBRM1, NUP107, CLASP2, NUP43, HELLS 326 111 12504 2.073288011938319 1.0 0.8881714144610594 90.88893667570399 GOTERM_CC_FAT GO:0000777~condensed chromosome kinetochore 3 0.49019607843137253 0.4023804942900285 NUP107, CLASP2, NUP43 326 53 12504 2.1710846162750324 1.0 0.9745807158221209 99.90415925611792 GOTERM_CC_FAT GO:0000779~condensed chromosome, centromeric region 3 0.49019607843137253 0.4647294309862139 NUP107, CLASP2, NUP43 326 60 12504 1.917791411042945 1.0 0.9772973570694552 99.97834705963561 SP_PIR_KEYWORDS kinetochore 3 0.49019607843137253 0.5149562100267127 NUP107, CLASP2, NUP43 503 61 17854 1.745657204315093 1.0 0.9703685573791115 99.99427488763976 GOTERM_CC_FAT GO:0000793~condensed chromosome 3 0.49019607843137253 0.7710216189537789 NUP107, CLASP2, NUP43 326 107 12504 1.0753970529212775 1.0 0.9953793309250707 99.9999997726483 Annotation Cluster 41 Enrichment Score: 0.48846333618067284 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011510:Sterile alpha motif homology 2 4 0.6535947712418301 0.09587353612014157 PPFIA2, EPHA4, PPP1R9A, 4930555K19RIK 500 39 17763 3.6436923076923082 1.0 0.9793545915629929 78.9584347089727 SMART SM00454:SAM 4 0.6535947712418301 0.4325003627075737 PPFIA2, EPHA4, PPP1R9A, 4930555K19RIK 253 87 9131 1.6593521421107627 1.0 0.9857195493678169 99.9150817179091 INTERPRO IPR001660:Sterile alpha motif SAM 4 0.6535947712418301 0.44365171380707513 PPFIA2, EPHA4, PPP1R9A, 4930555K19RIK 500 87 17763 1.6333793103448278 1.0 0.9994605514664187 99.98847207266913 INTERPRO IPR013761:Sterile alpha motif-type 3 0.49019607843137253 0.6045319657355956 EPHA4, PPP1R9A, 4930555K19RIK 500 72 17763 1.48025 1.0 0.9999457478704078 99.99994121451643 Annotation Cluster 42 Enrichment Score: 0.4762531354426695 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031080~Nup107-160 complex 3 0.49019607843137253 0.01700181309090473 NUP160, NUP107, NUP43 326 8 12504 14.383435582822088 0.9959316145513538 0.6004507233797264 20.666695744868314 GOTERM_CC_FAT GO:0000776~kinetochore 5 0.8169934640522877 0.07735996898945362 NUP160, PBRM1, NUP107, CLASP2, NUP43 326 62 12504 3.0932119532950724 0.9999999999940383 0.8421515046299839 66.27847829368294 GOTERM_CC_FAT GO:0000775~chromosome, centromeric region 6 0.9803921568627451 0.16259462646337905 NUP160, PBRM1, NUP107, CLASP2, NUP43, HELLS 326 111 12504 2.073288011938319 1.0 0.8881714144610594 90.88893667570399 SP_PIR_KEYWORDS nuclear pore complex 3 0.49019607843137253 0.2164021058143378 NUP160, NUP107, NUP43 503 31 17854 3.4350028859103445 1.0 0.9067140457403926 96.28317779075533 GOTERM_CC_FAT GO:0005643~nuclear pore 3 0.49019607843137253 0.4560527539803529 NUP160, NUP107, NUP43 326 59 12504 1.9502963502131643 1.0 0.9766884218599092 99.9730971206562 SP_PIR_KEYWORDS mRNA transport 3 0.49019607843137253 0.506122546110989 NUP160, NUP107, NUP43 503 60 17854 1.774751491053678 1.0 0.9693132987176818 99.99269522454838 GOTERM_BP_FAT GO:0051028~mRNA transport 3 0.49019607843137253 0.5123148294597952 NUP160, NUP107, NUP43 375 62 13588 1.753290322580645 1.0 0.9989766176230342 99.99936279685647 GOTERM_BP_FAT GO:0051236~establishment of RNA localization 3 0.49019607843137253 0.5460272963678279 NUP160, NUP107, NUP43 375 66 13588 1.6470303030303033 1.0 0.9991618996259214 99.99980681392545 GOTERM_BP_FAT GO:0050658~RNA transport 3 0.49019607843137253 0.5460272963678279 NUP160, NUP107, NUP43 375 66 13588 1.6470303030303033 1.0 0.9991618996259214 99.99980681392545 GOTERM_BP_FAT GO:0050657~nucleic acid transport 3 0.49019607843137253 0.5460272963678279 NUP160, NUP107, NUP43 375 66 13588 1.6470303030303033 1.0 0.9991618996259214 99.99980681392545 SP_PIR_KEYWORDS translocation 3 0.49019607843137253 0.5492293348637924 NUP160, NUP107, NUP43 503 65 17854 1.6382321455880102 1.0 0.9741095582365272 99.99787129141237 GOTERM_BP_FAT GO:0006403~RNA localization 3 0.49019607843137253 0.554197679045652 NUP160, NUP107, NUP43 375 67 13588 1.6224477611940298 1.0 0.9992256688246183 99.99985725258006 GOTERM_CC_FAT GO:0046930~pore complex 3 0.49019607843137253 0.5696084321761435 NUP160, NUP107, NUP43 326 73 12504 1.576266913185982 1.0 0.9863714813806318 99.99886012001386 GOTERM_BP_FAT GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport 3 0.49019607843137253 0.6084485183384896 NUP160, NUP107, NUP43 375 74 13588 1.468972972972973 1.0 0.9992739013586127 99.9999835677594 GOTERM_CC_FAT GO:0005635~nuclear envelope 4 0.6535947712418301 0.764107286703088 TRPC2, NUP160, NUP107, NUP43 326 153 12504 1.002766750872128 1.0 0.9951523315913897 99.99999966027347 Annotation Cluster 43 Enrichment Score: 0.474814954257838 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 10 6 0.9803921568627451 0.1566877363656223 1200009O22RIK, PPP1R7, LRRTM1, SHOC2, LRIG2, SLIT2 444 103 16021 2.1019417475728157 1.0 0.9991940357321025 93.73494240051585 UP_SEQ_FEATURE repeat:LRR 4 10 1.6339869281045754 0.1590515929503479 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, TSHR, SLIT2, LRRC51 444 221 16021 1.632730015082956 1.0 0.9990946865786022 94.0143831517965 UP_SEQ_FEATURE repeat:LRR 8 7 1.1437908496732025 0.16327202661928733 1200009O22RIK, PPP1R7, LRRTM1, SHOC2, LRIG2, TSHR, SLIT2 444 133 16021 1.8991228070175434 1.0 0.9990747229170592 94.48443240981625 UP_SEQ_FEATURE repeat:LRR 5 9 1.4705882352941175 0.2001624110762159 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, TSHR, SLIT2 444 203 16021 1.599753694581281 1.0 0.9994841210119789 97.34983675848969 INTERPRO IPR001611:Leucine-rich repeat 9 1.4705882352941175 0.2089781358765473 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, SLIT2, LRRC51 500 202 17763 1.5828415841584156 1.0 0.9953297313064813 97.33639121879794 UP_SEQ_FEATURE repeat:LRR 3 10 1.6339869281045754 0.23656719227702555 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, TSHR, SLIT2, LRRC51 444 245 16021 1.4727891156462585 1.0 0.99961869724652 98.75716543732874 UP_SEQ_FEATURE repeat:LRR 9 6 0.9803921568627451 0.24877746474622844 1200009O22RIK, PPP1R7, LRRTM1, SHOC2, LRIG2, SLIT2 444 122 16021 1.7745901639344264 1.0 0.9995894706494243 99.04370740205617 UP_SEQ_FEATURE repeat:LRR 7 7 1.1437908496732025 0.26807265053632995 1200009O22RIK, PPP1R7, LRRTM1, SHOC2, LRIG2, TSHR, SLIT2 444 157 16021 1.6088110403397027 1.0 0.9996599940197018 99.3735354775779 SMART SM00369:LRR_TYP 6 0.9803921568627451 0.28412510553627335 1200009O22RIK, LRRTM1, SHOC2, 4930555K19RIK, LRIG2, SLIT2 253 129 9131 1.6786469344608879 1.0 0.9732451657761191 98.45802017474772 INTERPRO IPR003591:Leucine-rich repeat, typical subtype 6 0.9803921568627451 0.2967978346739732 1200009O22RIK, LRRTM1, SHOC2, 4930555K19RIK, LRIG2, SLIT2 500 129 17763 1.6523720930232557 1.0 0.9974323337231079 99.56840791907472 UP_SEQ_FEATURE repeat:LRR 16 3 0.49019607843137253 0.31400696067244027 SHOC2, LRIG2, SLIT2 444 41 16021 2.6402439024390243 1.0 0.9997838622497391 99.78155601840729 UP_SEQ_FEATURE repeat:LRR 2 10 1.6339869281045754 0.31424775736664395 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, TSHR, SLIT2, LRRC51 444 266 16021 1.356516290726817 1.0 0.9997512980420205 99.78279910522222 UP_SEQ_FEATURE repeat:LRR 1 10 1.6339869281045754 0.31424775736664395 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, TSHR, SLIT2, LRRC51 444 266 16021 1.356516290726817 1.0 0.9997512980420205 99.78279910522222 SP_PIR_KEYWORDS leucine-rich repeat 10 1.6339869281045754 0.36850635593562886 1200009O22RIK, PPP1R7, LRRTM1, LRRCC1, SHOC2, 4930555K19RIK, LRIG2, TSHR, SLIT2, LRRC51 503 275 17854 1.2907283571299475 1.0 0.9566925478858767 99.79824845756917 UP_SEQ_FEATURE repeat:LRR 12 4 0.6535947712418301 0.37390072635893523 1200009O22RIK, SHOC2, LRIG2, SLIT2 444 79 16021 1.8270042194092828 1.0 0.999772485970716 99.9505245774475 UP_SEQ_FEATURE repeat:LRR 15 3 0.49019607843137253 0.38457110361933833 SHOC2, LRIG2, SLIT2 444 48 16021 2.2552083333333335 1.0 0.9997870971484225 99.96258557093962 UP_SEQ_FEATURE repeat:LRR 6 7 1.1437908496732025 0.40465580310759197 1200009O22RIK, PPP1R7, LRRTM1, SHOC2, LRIG2, TSHR, SLIT2 444 185 16021 1.3653153153153152 1.0 0.9998475130015197 99.97818248678239 UP_SEQ_FEATURE repeat:LRR 11 4 0.6535947712418301 0.44083677476858485 1200009O22RIK, SHOC2, LRIG2, SLIT2 444 88 16021 1.6401515151515151 1.0 0.9999226454629714 99.99212622094885 UP_SEQ_FEATURE repeat:LRR 14 3 0.49019607843137253 0.451828480474494 SHOC2, LRIG2, SLIT2 444 55 16021 1.9681818181818185 1.0 0.9999282681496346 99.99429798299671 UP_SEQ_FEATURE repeat:LRR 13 3 0.49019607843137253 0.5401719146038668 SHOC2, LRIG2, SLIT2 444 65 16021 1.6653846153846155 1.0 0.9999930788244406 99.99967234717329 SMART SM00082:LRRCT 3 0.49019607843137253 0.6725204902613553 1200009O22RIK, LRIG2, SLIT2 253 83 9131 1.3044906900328586 1.0 0.9972145886435262 99.99991117530949 INTERPRO IPR000483:Cysteine-rich flanking region, C-terminal 3 0.49019607843137253 0.6813687912319879 1200009O22RIK, LRIG2, SLIT2 500 83 17763 1.2840722891566265 1.0 0.9999887691115953 99.9999979189483 SMART SM00013:LRRNT 3 0.49019607843137253 0.73198325536989 1200009O22RIK, LRRTM1, SLIT2 253 93 9131 1.164222873900293 1.0 0.9988370319386864 99.99999271677845 INTERPRO IPR000372:Leucine-rich repeat, cysteine-rich flanking region, N-terminal 3 0.49019607843137253 0.7402268327894896 1200009O22RIK, LRRTM1, SLIT2 500 93 17763 1.146 1.0 0.9999959219776727 99.99999991156643 Annotation Cluster 44 Enrichment Score: 0.46435973024102456 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SET 3 0.49019607843137253 0.2831520724019792 WHSC1, SETD8, SETD5 444 38 16021 2.8486842105263164 1.0 0.9997212557639337 99.55338434052744 SMART SM00317:SET 3 0.49019607843137253 0.37387141795927414 WHSC1, SETD8, SETD5 253 47 9131 2.3036750483558994 1.0 0.9842348007486473 99.7102947097253 INTERPRO IPR001214:SET 3 0.49019607843137253 0.3821015501417675 WHSC1, SETD8, SETD5 500 47 17763 2.267617021276596 1.0 0.9988819879735306 99.94158784735862 Annotation Cluster 45 Enrichment Score: 0.45073947155229394 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005814~centriole 3 0.49019607843137253 0.11926621328976461 CEP170, CNTROB, LRRCC1 326 23 12504 5.002934115764204 1.0 0.8697562938038395 81.99647922635117 GOTERM_CC_FAT GO:0044450~microtubule organizing center part 3 0.49019607843137253 0.19222086483676137 CEP170, CNTROB, LRRCC1 326 31 12504 3.711854343954087 1.0 0.9209662856050174 94.39759930844117 GOTERM_CC_FAT GO:0005815~microtubule organizing center 6 0.9803921568627451 0.5481799338002635 CEP170, CNTROB, LRRCC1, TTLL4, SMEK1, CLASP2 326 189 12504 1.217645340344727 1.0 0.985741773661026 99.99780340354525 GOTERM_CC_FAT GO:0005813~centrosome 5 0.8169934640522877 0.6011444842877628 CEP170, CNTROB, LRRCC1, SMEK1, CLASP2 326 160 12504 1.1986196319018405 1.0 0.9869498702952635 99.99959197961677 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 11 1.7973856209150325 0.7380447308543009 KIF7, CEP170, CNTROB, LRRCC1, TTLL4, SMEK1, CLASP2, TCTE3, DST, JAKMIP1, KIFC3 326 450 12504 0.9375869120654396 1.0 0.9943764445512536 99.9999986017423 Annotation Cluster 46 Enrichment Score: 0.4476050972526852 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00165:UBA 3 0.49019607843137253 0.3538650094836707 CBL, MARK3, RSC1A1 253 45 9131 2.406060606060606 1.0 0.9858534093229163 99.57100025225407 UP_SEQ_FEATURE domain:UBA 3 0.49019607843137253 0.3546510692652216 CBL, MARK3, RSC1A1 444 45 16021 2.405555555555556 1.0 0.9998363158238538 99.91905903247857 INTERPRO IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote 3 0.49019607843137253 0.3618643614926492 CBL, MARK3, RSC1A1 500 45 17763 2.3684000000000003 1.0 0.9987379527136354 99.90384946407788 Annotation Cluster 47 Enrichment Score: 0.4468062696536327 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0040014~regulation of multicellular organism growth 5 0.8169934640522877 0.1517085798623654 SGPL1, ATXN2, AGT, TSHR, DLG1 375 75 13588 2.4156444444444447 1.0 0.9898361752700948 93.55041391827473 GOTERM_BP_FAT GO:0040018~positive regulation of multicellular organism growth 3 0.49019607843137253 0.1695286601734608 AGT, TSHR, DLG1 375 27 13588 4.026074074074074 1.0 0.9926501907586066 95.47190213244157 GOTERM_BP_FAT GO:0045927~positive regulation of growth 3 0.49019607843137253 0.45876792790855403 AGT, TSHR, DLG1 375 56 13588 1.9411428571428573 1.0 0.9984885925573362 99.99638539419713 GOTERM_BP_FAT GO:0051240~positive regulation of multicellular organismal process 6 0.9803921568627451 0.46714566617823733 GM98, SLC1A3, AGT, ATP2A1, TSHR, DLG1 375 163 13588 1.3337914110429447 1.0 0.9985970007702839 99.99721268325943 GOTERM_BP_FAT GO:0040008~regulation of growth 8 1.3071895424836601 0.5607728444479463 SGPL1, ATXN2, AGT, POT1B, WRN, APBB2, TSHR, DLG1 375 256 13588 1.1323333333333332 1.0 0.9991668879667966 99.99988855610347 GOTERM_BP_FAT GO:0001775~cell activation 7 1.1437908496732025 0.6746472609839671 FGG, AGT, VPREB1, PATZ1, TSHR, HELLS, DLG1 375 246 13588 1.0310677506775068 1.0 0.9995730143293413 99.99999924902262 Annotation Cluster 48 Enrichment Score: 0.43968413854715227 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009310~amine catabolic process 4 0.6535947712418301 0.265488434567497 AHCY, DIO2, BCKDHB, FTCD 375 65 13588 2.229825641025641 1.0 0.9959281697205132 99.41455951602185 GOTERM_BP_FAT GO:0046395~carboxylic acid catabolic process 4 0.6535947712418301 0.3861863678294235 AHCY, BCKDHB, FTCD, HADHA 375 81 13588 1.7893662551440328 1.0 0.9979450858283795 99.97058273665961 GOTERM_BP_FAT GO:0016054~organic acid catabolic process 4 0.6535947712418301 0.3861863678294235 AHCY, BCKDHB, FTCD, HADHA 375 81 13588 1.7893662551440328 1.0 0.9979450858283795 99.97058273665961 GOTERM_BP_FAT GO:0009063~cellular amino acid catabolic process 3 0.49019607843137253 0.440173568351789 AHCY, BCKDHB, FTCD 375 54 13588 2.013037037037037 1.0 0.9982646578929315 99.99365448258224 Annotation Cluster 49 Enrichment Score: 0.4304650729507105 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE DNA-binding region:HMG box 3 0.49019607843137253 0.2934599333132105 PBRM1, WHSC1, WDHD1 444 39 16021 2.7756410256410255 1.0 0.999730524280703 99.64707315236579 SMART SM00398:HMG 3 0.49019607843137253 0.41308990824628433 PBRM1, WHSC1, WDHD1 253 51 9131 2.122994652406417 1.0 0.9868282322534321 99.8707849824904 INTERPRO IPR000910:High mobility group, HMG1/HMG2 3 0.49019607843137253 0.42170755473238386 PBRM1, WHSC1, WDHD1 500 51 17763 2.089764705882353 1.0 0.999288506283789 99.97903101323583 Annotation Cluster 50 Enrichment Score: 0.4279595437424695 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005667~transcription factor complex 10 1.6339869281045754 0.15671998834119455 E2F3, RARG, YY1, HEYL, SNF8, ATP6V0A1, TAF9, ARNTL, ARNT, ASCL3 326 234 12504 1.6391379581563632 1.0 0.887932936237428 89.98713374060362 INTERPRO IPR011598:Helix-loop-helix DNA-binding 5 0.8169934640522877 0.21656640710506503 HEYL, ARNTL, MXD3, ARNT, ASCL3 500 85 17763 2.0897647058823527 1.0 0.9943049653871042 97.70528506251614 UP_SEQ_FEATURE domain:Helix-loop-helix motif 5 0.8169934640522877 0.35591871733900293 HEYL, ARNTL, MXD3, ARNT, ASCL3 444 109 16021 1.6551987767584098 1.0 0.999819519028668 99.92160510370091 SMART SM00353:HLH 4 0.6535947712418301 0.595538960572068 ARNTL, MXD3, ARNT, ASCL3 253 111 9131 1.3005733005733005 1.0 0.9935472984479385 99.99876109146021 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 4 0.6535947712418301 0.6069423076383431 ARNTL, MXD3, ARNT, ASCL3 500 111 17763 1.2802162162162163 1.0 0.9999425467442699 99.99994651785397 UP_SEQ_FEATURE DNA-binding region:Basic motif 5 0.8169934640522877 0.6196105981422324 HEYL, ARNTL, MXD3, ARNT, ASCL3 444 154 16021 1.1715367965367964 1.0 0.9999985836111779 99.9999849852385 Annotation Cluster 51 Enrichment Score: 0.4278581966124195 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044454~nuclear chromosome part 5 0.8169934640522877 0.27959724866638735 RNF2, RAD18, NUFIP1, POT1B, PURB 326 103 12504 1.861933408779558 1.0 0.9505959431237627 98.8055991716063 GOTERM_CC_FAT GO:0000228~nuclear chromosome 5 0.8169934640522877 0.38576214566953365 RNF2, RAD18, NUFIP1, POT1B, PURB 326 121 12504 1.5849515793743345 1.0 0.9714359934761834 99.86120639008149 GOTERM_CC_FAT GO:0000790~nuclear chromatin 3 0.49019607843137253 0.42056372953458876 RNF2, RAD18, NUFIP1 326 55 12504 2.092136084774122 1.0 0.9739923887995949 99.93684882320387 GOTERM_CC_FAT GO:0000785~chromatin 6 0.9803921568627451 0.42843298141011255 CHD9, HMGN3, RNF2, RAD18, NUFIP1, HELLS 326 165 12504 1.3947573898494146 1.0 0.9743821893765882 99.94749428385593 Annotation Cluster 52 Enrichment Score: 0.4278057181491979 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013111:EGF, extracellular 5 0.8169934640522877 0.13891141104021634 SVEP1, ADAM2, NTNG1, ADAM33, ADAM30 500 71 17763 2.5018309859154932 1.0 0.9923430063622692 90.10295630959722 SMART SM00608:ACR 3 0.49019607843137253 0.241166186103896 ADAM2, ADAM33, ADAM30 253 34 9131 3.1844919786096253 1.0 0.9785901117133506 96.80852001524588 INTERPRO IPR006586:ADAM, cysteine-rich 3 0.49019607843137253 0.24745173225726153 ADAM2, ADAM33, ADAM30 500 34 17763 3.1346470588235293 1.0 0.9952564629759296 98.76806932334546 SMART SM00050:DISIN 3 0.49019607843137253 0.27209700313861396 ADAM2, ADAM33, ADAM30 253 37 9131 2.926289926289926 1.0 0.9791540893604859 98.10153301837528 INTERPRO IPR001762:Blood coagulation inhibitor, Disintegrin 3 0.49019607843137253 0.2789229531197833 ADAM2, ADAM33, ADAM30 500 37 17763 2.880486486486487 1.0 0.9968813384636095 99.36369360449723 INTERPRO IPR000742:EGF-like, type 3 8 1.3071895424836601 0.32678600120107765 TMEFF2, TMEFF1, SVEP1, ADAM2, NTNG1, ADAM33, ADAM30, SLIT2 500 199 17763 1.428180904522613 1.0 0.9982065362485796 99.78002984290669 INTERPRO IPR018358:Disintegrin, conserved site 3 0.49019607843137253 0.3720157107292272 ADAM2, ADAM33, ADAM30 500 46 17763 2.316913043478261 1.0 0.9987429100130937 99.92496756519269 INTERPRO IPR002870:Peptidase M12B, propeptide 3 0.49019607843137253 0.42170755473238386 ADAM2, ADAM33, ADAM30 500 51 17763 2.089764705882353 1.0 0.999288506283789 99.97903101323583 INTERPRO IPR001590:Peptidase M12B, ADAM/reprolysin 3 0.49019607843137253 0.4410182969734523 ADAM2, ADAM33, ADAM30 500 53 17763 2.0109056603773587 1.0 0.999489028919924 99.9875986852174 INTERPRO IPR013032:EGF-like region, conserved site 9 1.4705882352941175 0.6457876248592563 TMEFF2, TMEFF1, SVEP1, ADAM2, NTNG1, ADAM33, ADAM30, CLEC14A, SLIT2 500 310 17763 1.0313999999999999 1.0 0.9999779085542411 99.99998930208153 GOTERM_MF_FAT GO:0004222~metalloendopeptidase activity 3 0.49019607843137253 0.827247302716738 ADAM2, ADAM33, ADAM30 368 114 13288 0.9502288329519452 1.0 0.9996209322511266 99.99999999894126 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 3 0.49019607843137253 0.9672990025056154 ADAM2, ADAM33, ADAM30 368 187 13288 0.5792838874680306 1.0 0.9999966857857592 100.0 Annotation Cluster 53 Enrichment Score: 0.42528727141056416 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006672~ceramide metabolic process 3 0.49019607843137253 0.2607943774923919 SGPL1, CLN8, B4GALNT1 375 36 13588 3.0195555555555558 1.0 0.995718470356958 99.34900775060305 GOTERM_BP_FAT GO:0046519~sphingoid metabolic process 3 0.49019607843137253 0.2813531344621183 SGPL1, CLN8, B4GALNT1 375 38 13588 2.8606315789473684 1.0 0.9959490907036082 99.59309746329978 GOTERM_BP_FAT GO:0006665~sphingolipid metabolic process 3 0.49019607843137253 0.5123148294597952 SGPL1, CLN8, B4GALNT1 375 62 13588 1.753290322580645 1.0 0.9989766176230342 99.99936279685647 GOTERM_BP_FAT GO:0006643~membrane lipid metabolic process 3 0.49019607843137253 0.5293757040017412 SGPL1, CLN8, B4GALNT1 375 64 13588 1.6985 1.0 0.9989738637714616 99.99964793627377 Annotation Cluster 54 Enrichment Score: 0.41539521553984493 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 6 0.9803921568627451 0.03979301015591754 TMEFF2, TMEFF1, ADAM2, ADAM33, TMEM8, CLEC14A 444 68 16021 3.183823529411765 1.0 0.9856408678024262 48.318288630061446 INTERPRO IPR000742:EGF-like, type 3 8 1.3071895424836601 0.32678600120107765 TMEFF2, TMEFF1, SVEP1, ADAM2, NTNG1, ADAM33, ADAM30, SLIT2 500 199 17763 1.428180904522613 1.0 0.9982065362485796 99.78002984290669 SP_PIR_KEYWORDS egf-like domain 8 1.3071895424836601 0.4334924882779808 TMEFF2, TMEFF1, SVEP1, ADAM2, ADAM33, TMEM8, CLEC14A, SLIT2 503 222 17854 1.2791001737323804 1.0 0.9592471240136845 99.9534335294549 SMART SM00181:EGF 7 1.1437908496732025 0.49144608939092416 TMEFF2, TMEFF1, SVEP1, NTNG1, ADAM33, CLEC14A, SLIT2 253 203 9131 1.244514106583072 1.0 0.989398447437397 99.97839761675658 INTERPRO IPR006210:EGF-like 7 1.1437908496732025 0.5077750882674327 TMEFF2, TMEFF1, SVEP1, NTNG1, ADAM33, CLEC14A, SLIT2 500 203 17763 1.2250344827586208 1.0 0.9997873615990622 99.99826513374562 INTERPRO IPR013032:EGF-like region, conserved site 9 1.4705882352941175 0.6457876248592563 TMEFF2, TMEFF1, SVEP1, ADAM2, NTNG1, ADAM33, ADAM30, CLEC14A, SLIT2 500 310 17763 1.0313999999999999 1.0 0.9999779085542411 99.99998930208153 INTERPRO IPR006209:EGF 4 0.6535947712418301 0.7015532309181949 TMEFF2, TMEFF1, SVEP1, SLIT2 500 128 17763 1.1101875 1.0 0.9999922821361595 99.99999924361761 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site 3 0.49019607843137253 0.7455707150952966 SVEP1, CLEC14A, SLIT2 500 94 17763 1.133808510638298 1.0 0.9999961435619489 99.99999993587751 Annotation Cluster 55 Enrichment Score: 0.4130487433466371 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050878~regulation of body fluid levels 5 0.8169934640522877 0.229660914617059 FGG, LNP, BLOC1S3, CLCNKA, TFPI 375 89 13588 2.0356554307116106 1.0 0.9948386383392103 98.70558102566868 GOTERM_BP_FAT GO:0050817~coagulation 4 0.6535947712418301 0.3031238019141429 FGG, LNP, BLOC1S3, TFPI 375 70 13588 2.070552380952381 1.0 0.9964932444318907 99.75627002088935 GOTERM_BP_FAT GO:0007596~blood coagulation 4 0.6535947712418301 0.3031238019141429 FGG, LNP, BLOC1S3, TFPI 375 70 13588 2.070552380952381 1.0 0.9964932444318907 99.75627002088935 GOTERM_BP_FAT GO:0007599~hemostasis 4 0.6535947712418301 0.31069030313222684 FGG, LNP, BLOC1S3, TFPI 375 71 13588 2.041389671361502 1.0 0.9964858643134593 99.79680271280633 GOTERM_BP_FAT GO:0042060~wound healing 4 0.6535947712418301 0.5993421768328884 FGG, LNP, BLOC1S3, TFPI 375 112 13588 1.2940952380952382 1.0 0.9992498423659509 99.99997589834443 GOTERM_BP_FAT GO:0009611~response to wounding 8 1.3071895424836601 0.8460145482372229 FGG, SLC1A2, LNP, SLC1A3, DARC, BLOC1S3, CFH, TFPI 375 347 13588 0.8353813640730067 1.0 0.9999479024448794 99.99999999999709 Annotation Cluster 56 Enrichment Score: 0.4122101406342048 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:HEAT 2 3 0.49019607843137253 0.38457110361933833 2310035C23RIK, HEATR5A, CLASP2 444 48 16021 2.2552083333333335 1.0 0.9997870971484225 99.96258557093962 UP_SEQ_FEATURE repeat:HEAT 1 3 0.49019607843137253 0.38457110361933833 2310035C23RIK, HEATR5A, CLASP2 444 48 16021 2.2552083333333335 1.0 0.9997870971484225 99.96258557093962 INTERPRO IPR000357:HEAT 3 0.49019607843137253 0.3921175504587529 2310035C23RIK, HEATR5A, CLASP2 500 48 17763 2.220375 1.0 0.9988864829795302 99.95463307448999 Annotation Cluster 57 Enrichment Score: 0.40191582865989045 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:NR C4-type 3 0.49019607843137253 0.36468603994493715 ESRRA, RARG, RORB 444 46 16021 2.3532608695652173 1.0 0.9997945772535991 99.93726178777845 UP_SEQ_FEATURE DNA-binding region:Nuclear receptor 3 0.49019607843137253 0.36468603994493715 ESRRA, RARG, RORB 444 46 16021 2.3532608695652173 1.0 0.9997945772535991 99.93726178777845 SMART SM00399:ZnF_C4 3 0.49019607843137253 0.37387141795927414 ESRRA, RARG, RORB 253 47 9131 2.3036750483558994 1.0 0.9842348007486473 99.7102947097253 INTERPRO IPR001628:Zinc finger, nuclear hormone receptor-type 3 0.49019607843137253 0.3821015501417675 ESRRA, RARG, RORB 500 47 17763 2.267617021276596 1.0 0.9988819879735306 99.94158784735862 INTERPRO IPR001723:Steroid hormone receptor 3 0.49019607843137253 0.3921175504587529 ESRRA, RARG, RORB 500 48 17763 2.220375 1.0 0.9988864829795302 99.95463307448999 SMART SM00430:HOLI 3 0.49019607843137253 0.39362358236574907 ESRRA, RARG, RORB 253 49 9131 2.209647495361781 1.0 0.9856109351935823 99.80582566193509 GOTERM_MF_FAT GO:0003707~steroid hormone receptor activity 3 0.49019607843137253 0.3938860169443285 ESRRA, RARG, RORB 368 49 13288 2.2107364685004436 1.0 0.9843252465885617 99.9257910460894 INTERPRO IPR008946:Nuclear hormone receptor, ligand-binding 3 0.49019607843137253 0.4020596762941188 ESRRA, RARG, RORB 500 49 17763 2.175061224489796 1.0 0.9990062233972437 99.9648454399168 INTERPRO IPR000536:Nuclear hormone receptor, ligand-binding, core 3 0.49019607843137253 0.4020596762941188 ESRRA, RARG, RORB 500 49 17763 2.175061224489796 1.0 0.9990062233972437 99.9648454399168 INTERPRO IPR013088:Zinc finger, NHR/GATA-type 3 0.49019607843137253 0.4410182969734523 ESRRA, RARG, RORB 500 53 17763 2.0109056603773587 1.0 0.999489028919924 99.9875986852174 GOTERM_MF_FAT GO:0004879~ligand-dependent nuclear receptor activity 3 0.49019607843137253 0.4605544075397809 ESRRA, RARG, RORB 368 56 13288 1.9343944099378882 1.0 0.9911629644223561 99.98612892366108 Annotation Cluster 58 Enrichment Score: 0.3952472922001259 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016568~chromatin modification 10 1.6339869281045754 0.20583400092674914 CHD9, RNF2, PHF16, RCOR1, PBRM1, WHSC1, SETD8, TLK2, HLTF, HELLS 375 236 13588 1.5353672316384184 1.0 0.9952826757494024 97.84978777417084 SP_PIR_KEYWORDS chromatin regulator 7 1.1437908496732025 0.454929239434091 CHD9, RCOR1, PBRM1, WHSC1, SETD8, TLK2, HLTF 503 192 17854 1.2940896288933068 1.0 0.9631765036565232 99.97233715157357 GOTERM_BP_FAT GO:0006325~chromatin organization 10 1.6339869281045754 0.5021014575441003 CHD9, RNF2, PHF16, RCOR1, PBRM1, WHSC1, SETD8, TLK2, HLTF, HELLS 375 315 13588 1.1503068783068784 1.0 0.9989013636648277 99.99909999832451 GOTERM_BP_FAT GO:0051276~chromosome organization 12 1.9607843137254901 0.5581595790207435 CHD9, RNF2, PHF16, RCOR1, PBRM1, WHSC1, SETD8, POT1B, TLK2, WRN, HLTF, HELLS 375 404 13588 1.0762772277227723 1.0 0.9992228618397626 99.99987697939792 Annotation Cluster 59 Enrichment Score: 0.3633525467698792 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005789~endoplasmic reticulum membrane 6 0.9803921568627451 0.36130677889003704 TRPC2, STT3A, H13, ATP2A1, GOSR2, DLG1 326 152 12504 1.5140458508233774 1.0 0.9750307263434644 99.76488205441474 GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 6 0.9803921568627451 0.4026953765671236 TRPC2, STT3A, H13, ATP2A1, GOSR2, DLG1 326 160 12504 1.4383435582822088 1.0 0.9725693283286208 99.90483877911939 GOTERM_CC_FAT GO:0044432~endoplasmic reticulum part 7 1.1437908496732025 0.5585854336744953 TRPC2, STT3A, H13, ATP2A1, FKBP14, GOSR2, DLG1 326 231 12504 1.1622978248745122 1.0 0.9864768355971777 99.99839624726698 Annotation Cluster 60 Enrichment Score: 0.3453953496974637 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005913~cell-cell adherens junction 3 0.49019607843137253 0.19222086483676137 SORBS1, CTNNA1, DLG1 326 31 12504 3.711854343954087 1.0 0.9209662856050174 94.39759930844117 GOTERM_CC_FAT GO:0005912~adherens junction 4 0.6535947712418301 0.5229407767889576 SORBS1, VEZT, CTNNA1, DLG1 326 106 12504 1.4473897441833548 1.0 0.9845170214216412 99.99542426067114 GOTERM_CC_FAT GO:0070161~anchoring junction 4 0.6535947712418301 0.6239842713456044 SORBS1, VEZT, CTNNA1, DLG1 326 123 12504 1.2473440071824031 1.0 0.9894370678671864 99.99981595191804 GOTERM_CC_FAT GO:0005911~cell-cell junction 5 0.8169934640522877 0.6622041894781815 SORBS1, CLDN5, GJB4, CTNNA1, DLG1 326 173 12504 1.1085499485797368 1.0 0.989786268522122 99.99995670434711 Annotation Cluster 61 Enrichment Score: 0.3428483656497036 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006820~anion transport 6 0.9803921568627451 0.2878260191707642 SLC1A2, SLC1A3, SLC26A5, GLRA2, CLCNKA, CLN8 375 130 13588 1.6723692307692308 1.0 0.9958346309034256 99.6500351356995 GOTERM_MF_FAT GO:0008509~anion transmembrane transporter activity 5 0.8169934640522877 0.4851108149516292 SLC1A2, SLC1A3, SLC26A5, GLRA2, CLCNKA 368 130 13288 1.3887959866220736 1.0 0.9928019347096012 99.99290588698612 GOTERM_BP_FAT GO:0015698~inorganic anion transport 3 0.49019607843137253 0.6706314172994211 SLC26A5, GLRA2, CLCNKA 375 83 13588 1.3096867469879518 1.0 0.9995816181533372 99.99999907872652 Annotation Cluster 62 Enrichment Score: 0.33964763333292947 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS synapse 11 1.7973856209150325 0.0786711847093722 GPR156, SYT1, GLRA2, GRID2, CHRNB3, ABI1, VAMP2, CHRNB1, ZNRF1, ITSN1, DLG1 503 213 17854 1.8330766574263342 0.9999999999962234 0.7871542697199112 66.91976969263722 SP_PIR_KEYWORDS cell junction 17 2.7777777777777777 0.08874189391507076 GPR156, SYT1, CLDN5, GLRA2, GJB4, ABI1, VEZT, CTNNA1, ZNRF1, ITSN1, SORBS1, SORBS2, GRID2, CHRNB3, VAMP2, CHRNB1, DLG1 503 392 17854 1.5393252728526798 0.9999999999998891 0.8093346761476141 71.48156280429102 GOTERM_CC_FAT GO:0044456~synapse part 10 1.6339869281045754 0.10207149921310801 GPR156, SYT1, SLC1A2, GLRA2, GRID2, CHRNB3, NUFIP1, VAMP2, CHRNB1, DLG1 326 212 12504 1.8092371802291933 0.999999999999999 0.8690533645342893 76.6264217726184 GOTERM_CC_FAT GO:0030054~cell junction 18 2.941176470588235 0.10653352841570388 GPR156, SYT1, GLRA2, CLDN5, GJB4, ABI1, VEZT, CTNNA1, ZNRF1, ITSN1, SORBS1, GRID2, CHRNB3, VAMP2, CHRNB1, PDZD2, DST, DLG1 326 470 12504 1.468946612713745 0.9999999999999998 0.865858765656895 78.14674094764135 GOTERM_CC_FAT GO:0045202~synapse 13 2.1241830065359477 0.12983593942868377 GPR156, SYT1, GLRA2, NUFIP1, ABI1, ZNRF1, ITSN1, SLC1A2, GRID2, CHRNB3, CHRNB1, VAMP2, DLG1 326 319 12504 1.5630901782795161 1.0 0.8685605431549779 84.70442971341153 SP_PIR_KEYWORDS postsynaptic cell membrane 6 0.9803921568627451 0.19780435779755534 GPR156, GLRA2, GRID2, CHRNB3, CHRNB1, DLG1 503 110 17854 1.9360925356949212 1.0 0.9054200253949425 94.89841422115043 PIR_SUPERFAMILY PIRSF002443:acetylcholine receptor 3 0.49019607843137253 0.2154371769826208 GLRA2, CHRNB3, CHRNB1 203 35 8136 3.4353272343420125 1.0 0.9999939176362904 95.19778742125742 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 6 0.9803921568627451 0.23040469790562149 GPR156, GLRA2, GRID2, CHRNB3, CHRNB1, DLG1 326 126 12504 1.8264680105170903 1.0 0.9335850914524205 97.0862731754069 GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 4 0.6535947712418301 0.27467538236853206 GLRA2, GRID2, CHRNB3, CHRNB1 368 66 13288 2.1884057971014492 1.0 0.9736074990304769 99.016576182429 INTERPRO IPR018000:Neurotransmitter-gated ion-channel, conserved site 3 0.49019607843137253 0.32070151176546746 GLRA2, CHRNB3, CHRNB1 500 41 17763 2.5994634146341467 1.0 0.9981612345899397 99.7471901656432 INTERPRO IPR006202:Neurotransmitter-gated ion-channel ligand-binding 3 0.49019607843137253 0.3310652441751222 GLRA2, CHRNB3, CHRNB1 500 42 17763 2.5375714285714284 1.0 0.9981756340517868 99.80068730776853 INTERPRO IPR006201:Neurotransmitter-gated ion-channel 3 0.49019607843137253 0.3310652441751222 GLRA2, CHRNB3, CHRNB1 500 42 17763 2.5375714285714284 1.0 0.9981756340517868 99.80068730776853 INTERPRO IPR006029:Neurotransmitter-gated ion-channel transmembrane region 3 0.49019607843137253 0.3310652441751222 GLRA2, CHRNB3, CHRNB1 500 42 17763 2.5375714285714284 1.0 0.9981756340517868 99.80068730776853 GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 5 0.8169934640522877 0.3362173494567602 TRPC2, GLRA2, GRID2, CHRNB3, CHRNB1 368 106 13288 1.7032403609515996 1.0 0.9787325690337276 99.7254993829418 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 5 0.8169934640522877 0.3362173494567602 TRPC2, GLRA2, GRID2, CHRNB3, CHRNB1 368 106 13288 1.7032403609515996 1.0 0.9787325690337276 99.7254993829418 GOTERM_MF_FAT GO:0022836~gated channel activity 9 1.4705882352941175 0.512979519897131 TRPC2, KCNT1, GLRA2, CLCNKA, GRID2, CHRNB3, KCTD3, CHRNB1, KCNH5 368 281 13288 1.1565062664397339 1.0 0.9940142071562472 99.99681517236195 GOTERM_CC_FAT GO:0034702~ion channel complex 5 0.8169934640522877 0.5911856880427677 STXBP5, GLRA2, CLCNKA, KCTD3, CHRNB1 326 158 12504 1.2137920323056612 1.0 0.987099570441725 99.99943077720404 GOTERM_BP_FAT GO:0006811~ion transport 19 3.104575163398693 0.6800520815361293 TRPC2, GLRA2, CLCNKA, KCTD3, SLC1A2, KCNT1, SLC26A5, SLC1A3, ATP2A1, GRID2, CHRNB3, ATP6V0A1, SLC13A4, SLC22A5, CHRNB1, TMCO3, STEAP2, CLN8, KCNH5 375 712 13588 0.966936329588015 1.0 0.9996060163867757 99.99999943190701 GOTERM_MF_FAT GO:0042165~neurotransmitter binding 3 0.49019607843137253 0.6974334281576424 GLRA2, CHRNB3, CHRNB1 368 87 13288 1.245127436281859 1.0 0.9983408719835656 99.99999662852996 GOTERM_MF_FAT GO:0030594~neurotransmitter receptor activity 3 0.49019607843137253 0.6974334281576424 GLRA2, CHRNB3, CHRNB1 368 87 13288 1.245127436281859 1.0 0.9983408719835656 99.99999662852996 SP_PIR_KEYWORDS ionic channel 8 1.3071895424836601 0.7459111725175288 TRPC2, KCNT1, GLRA2, CLCNKA, GRID2, CHRNB3, CHRNB1, KCNH5 503 301 17854 0.9433894969056096 1.0 0.9924528694357664 99.99999907356464 GOTERM_MF_FAT GO:0005216~ion channel activity 9 1.4705882352941175 0.7526800588220279 TRPC2, KCNT1, GLRA2, CLCNKA, GRID2, CHRNB3, KCTD3, CHRNB1, KCNH5 368 349 13288 0.931169801918525 1.0 0.9992326740485162 99.999999814816 GOTERM_MF_FAT GO:0022838~substrate specific channel activity 9 1.4705882352941175 0.7820418098070994 TRPC2, KCNT1, GLRA2, CLCNKA, GRID2, CHRNB3, KCTD3, CHRNB1, KCNH5 368 360 13288 0.9027173913043478 1.0 0.9994115569831502 99.99999996996218 GOTERM_CC_FAT GO:0044459~plasma membrane part 39 6.372549019607843 0.7934923504198846 SYT1, GLRA2, CLDN5, VPREB1, ABI1, MITD1, ITSN1, ZNRF1, IL17RB, AP1S3, SLC1A2, SORBS1, GRID2, SLC22A5, DLG1, RHEBL1, TRPC2, GPR156, MS4A4B, STX3, CBL, MET, NTNG1, SLC6A14, ITGA1, TMEM8, GJB4, VEZT, KCTD3, CTNNA1, GNAL, EPHA4, SLC26A5, STXBP5, CHRNB3, VAMP2, CHRNB1, PDZD2, DST 326 1633 12504 0.9160301902103473 1.0 0.9963974868136152 99.99999994362668 GOTERM_MF_FAT GO:0015267~channel activity 9 1.4705882352941175 0.794516490724659 TRPC2, KCNT1, GLRA2, CLCNKA, GRID2, CHRNB3, KCTD3, CHRNB1, KCNH5 368 365 13288 0.8903513996426445 1.0 0.9994497001902518 99.99999998713885 GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 9 1.4705882352941175 0.794516490724659 TRPC2, KCNT1, GLRA2, CLCNKA, GRID2, CHRNB3, KCTD3, CHRNB1, KCNH5 368 365 13288 0.8903513996426445 1.0 0.9994497001902518 99.99999998713885 GOTERM_MF_FAT GO:0046873~metal ion transmembrane transporter activity 7 1.1437908496732025 0.8164731790509946 TRPC2, KCNT1, ATP2A1, CHRNB3, KCTD3, CHRNB1, KCNH5 368 290 13288 0.8715892053973013 1.0 0.9995974342930787 99.99999999747104 GOTERM_MF_FAT GO:0005261~cation channel activity 6 0.9803921568627451 0.8192826046645347 TRPC2, KCNT1, CHRNB3, KCTD3, CHRNB1, KCNH5 368 248 13288 0.8735974754558204 1.0 0.999596934193275 99.99999999797456 SP_PIR_KEYWORDS ion transport 13 2.1241830065359477 0.8401168390526798 TRPC2, GLRA2, CLCNKA, KCNT1, ATP2A1, GRID2, CHRNB3, ATP6V0A1, SLC22A5, CHRNB1, TMCO3, STEAP2, KCNH5 503 543 17854 0.8497889275763467 1.0 0.9965125620411069 99.99999999821893 GOTERM_MF_FAT GO:0005267~potassium channel activity 3 0.49019607843137253 0.8754462216893533 KCNT1, KCTD3, KCNH5 368 129 13288 0.839737108190091 1.0 0.9998108709782025 99.99999999999045 GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 6 0.9803921568627451 0.9234222200671524 KCNT1, ATP6V0A1, KCTD3, SLC13A4, SLC22A5, KCNH5 375 303 13588 0.7175181518151815 1.0 0.9999943879487219 100.0 GOTERM_BP_FAT GO:0006813~potassium ion transport 3 0.49019607843137253 0.9374936354532956 KCNT1, KCTD3, KCNH5 375 160 13588 0.6794 1.0 0.9999974714469164 100.0 GOTERM_BP_FAT GO:0006812~cation transport 10 1.6339869281045754 0.9487051552517746 TRPC2, KCNT1, ATP2A1, ATP6V0A1, KCTD3, SLC13A4, SLC22A5, STEAP2, TMCO3, KCNH5 375 515 13588 0.7035857605177994 1.0 0.9999987091604009 100.0 GOTERM_MF_FAT GO:0005244~voltage-gated ion channel activity 3 0.49019607843137253 0.9604584359929917 CLCNKA, KCTD3, KCNH5 368 179 13288 0.6051736701481661 1.0 0.9999944170561186 100.0 GOTERM_MF_FAT GO:0022832~voltage-gated channel activity 3 0.49019607843137253 0.9604584359929917 CLCNKA, KCTD3, KCNH5 368 179 13288 0.6051736701481661 1.0 0.9999944170561186 100.0 GOTERM_BP_FAT GO:0030001~metal ion transport 8 1.3071895424836601 0.962493053820361 TRPC2, KCNT1, ATP2A1, KCTD3, SLC13A4, SLC22A5, STEAP2, KCNH5 375 442 13588 0.6558310708898945 1.0 0.9999995619405926 100.0 GOTERM_MF_FAT GO:0031420~alkali metal ion binding 3 0.49019607843137253 0.979288554240775 KCNT1, SLC22A5, KCNH5 368 206 13288 0.5258547910510764 1.0 0.9999993170974593 100.0 Annotation Cluster 63 Enrichment Score: 0.332549448403567 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003700~transcription factor activity 29 4.738562091503268 0.08805717313714168 GM98, E2F3, RORB, NFKB1, NFXL1, ZKSCAN5, ARNT, TSC22D2, ZSCAN20, NFAT5, ETV4, A130010J15RIK, ESRRA, RARG, RAX, YY1, ZFP449, ARNTL, PURB, FOXP2, MEF2D, FOXI2, UPF3B, IRF5, HEYL, ZFP263, LCOR, TBX19, NFIB 368 776 13288 1.349422904527118 1.0 0.9707280547841766 73.46360894187525 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 22 3.594771241830065 0.18378782952385042 MBD3L1, ESRRA, RARG, RFX5, NUFIP1, NFKB1, ARNTL, HLTF, NRIP1, ARNT, FOXP2, MED19, RNF2, SNF8, HEYL, NFAT5, TCEB3, TAF9, LCOR, TBX19, NFIB, ASCL3 375 616 13588 1.2940952380952382 1.0 0.9934258871555762 96.60684913808271 SP_PIR_KEYWORDS activator 16 2.6143790849673203 0.3859019949486807 GM98, E2F3, YY1, RORB, NFKB1, ARNTL, HLTF, ARNT, MED19, MEF2D, FOXI2, NFAT5, LCOR, ETV4, TBX19, NFIB 503 484 17854 1.1733894155726794 1.0 0.9535331656910738 99.86163241543822 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 13 2.1241830065359477 0.4702602566951874 GM98, ESRRA, E2F3, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, NFAT5, TAF9, TBX19, NFIB 375 416 13588 1.1323333333333332 1.0 0.9984931162584423 99.99747204212328 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 13 2.1241830065359477 0.4881665124863669 GM98, ESRRA, E2F3, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, NFAT5, TAF9, TBX19, NFIB 375 419 13588 1.124225934765314 1.0 0.9987334579389744 99.99857450517045 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 14 2.287581699346405 0.5487223987903133 GM98, ESRRA, E2F3, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, NFAT5, TAF9, ETV4, TBX19, NFIB 375 475 13588 1.0679691228070176 1.0 0.999171827752273 99.99982505858563 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 16 2.6143790849673203 0.5581954225493847 GM98, E2F3, ESRRA, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, SORBS1, AGT, NFAT5, TAF9, ETV4, TBX19, NFIB 375 552 13588 1.050280193236715 1.0 0.9991911671663964 99.99987714556039 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 16 2.6143790849673203 0.5724801278141451 GM98, E2F3, ESRRA, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, SORBS1, AGT, NFAT5, TAF9, ETV4, TBX19, NFIB 375 557 13588 1.0408521843207659 1.0 0.9991937194216474 99.99992894710256 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 14 2.287581699346405 0.5883700895122111 GM98, ESRRA, E2F3, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, NFAT5, TAF9, ETV4, TBX19, NFIB 375 488 13588 1.0395191256830603 1.0 0.9992279407262072 99.99996219681513 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 15 2.450980392156863 0.60175300651284 GM98, E2F3, ESRRA, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, SORBS1, NFAT5, TAF9, ETV4, TBX19, NFIB 375 530 13588 1.0255094339622641 1.0 0.9992300425587418 99.99997820394334 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 14 2.287581699346405 0.6518238621443009 GM98, ESRRA, E2F3, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, NFAT5, TAF9, ETV4, TBX19, NFIB 375 510 13588 0.9946771241830066 1.0 0.999480587396566 99.99999767627453 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 10 1.6339869281045754 0.656333972363965 ESRRA, RARG, NFAT5, NUFIP1, NFKB1, TAF9, ARNTL, TBX19, ARNT, NFIB 375 358 13588 1.012141527001862 1.0 0.9995097827378474 99.99999812997712 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 14 2.287581699346405 0.694531111703705 GM98, ESRRA, E2F3, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, NFAT5, TAF9, ETV4, TBX19, NFIB 375 526 13588 0.9644207858048163 1.0 0.9996573728859842 99.99999973737248 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 15 2.450980392156863 0.835464257459602 GM98, E2F3, ESRRA, RARG, NUFIP1, RORB, NFKB1, ARNTL, ARNT, SORBS1, NFAT5, TAF9, ETV4, TBX19, NFIB 375 633 13588 0.8586413902053712 1.0 0.9999374388091782 99.99999999999125 Annotation Cluster 64 Enrichment Score: 0.326756675183721 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cytoplasmic vesicle 9 1.4705882352941175 0.3293118685236279 PCSK2, AP1S3, SYT1, CHIC1, ATP6V0A1, VEZT, VAMP2, ZNRF1, KIFC3 503 232 17854 1.3769623637485433 1.0 0.9457513322970987 99.54513187305334 GOTERM_CC_FAT GO:0030141~secretory granule 5 0.8169934640522877 0.36208253585476524 PCSK2, SYT1, VEZT, VAMP2, ABCA3 326 117 12504 1.6391379581563632 1.0 0.9728834116915481 99.76870840891071 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 12 1.9607843137254901 0.5142666314876537 PCSK2, AP1S3, SYT1, CHIC1, AHCY, ATP6V0A1, VEZT, VAMP2, STEAP2, ITSN1, DST, ABCA3 326 414 12504 1.1117631368364898 1.0 0.9840636746414615 99.99416401863938 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 12 1.9607843137254901 0.5326749656140333 PCSK2, AP1S3, SYT1, CHIC1, AHCY, ATP6V0A1, VEZT, VAMP2, STEAP2, ITSN1, DST, ABCA3 326 420 12504 1.095880806310254 1.0 0.9851573205044271 99.99653594303278 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 14 2.287581699346405 0.5635142376245644 SYT1, AHCY, VEZT, ZNRF1, ITSN1, ABCA3, KIFC3, PCSK2, AP1S3, CHIC1, ATP6V0A1, VAMP2, STEAP2, DST 326 508 12504 1.0570503840394185 1.0 0.9863235262933497 99.99862184017368 GOTERM_CC_FAT GO:0031982~vesicle 14 2.287581699346405 0.5949623199880972 SYT1, AHCY, VEZT, ZNRF1, ITSN1, ABCA3, KIFC3, PCSK2, AP1S3, CHIC1, ATP6V0A1, VAMP2, STEAP2, DST 326 519 12504 1.0346466186744212 1.0 0.9868328126478212 99.99949781354694 Annotation Cluster 65 Enrichment Score: 0.3179058515605007 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001570~vasculogenesis 3 0.49019607843137253 0.33242233890160094 SGPL1, MYO1E, TNNI3 375 43 13588 2.528 1.0 0.9969522522888088 99.8808405605382 GOTERM_BP_FAT GO:0001568~blood vessel development 9 1.4705882352941175 0.3575664115796179 COL18A1, SGPL1, AGT, MYO1E, DICER1, SPINT1, TNNI3, FZD5, NSDHL 375 244 13588 1.3365245901639344 1.0 0.9974051645996508 99.9371449449722 GOTERM_BP_FAT GO:0001944~vasculature development 9 1.4705882352941175 0.38259363577894884 COL18A1, SGPL1, AGT, MYO1E, DICER1, SPINT1, TNNI3, FZD5, NSDHL 375 250 13588 1.304448 1.0 0.9980033446252868 99.96757878567567 GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 6 0.9803921568627451 0.6394778310529627 COL18A1, SGPL1, MYO1E, DICER1, TNNI3, FZD5 375 198 13588 1.098020202020202 1.0 0.9994402322234915 99.99999584753206 GOTERM_BP_FAT GO:0001525~angiogenesis 3 0.49019607843137253 0.8848315313155254 COL18A1, DICER1, FZD5 375 133 13588 0.8173233082706767 1.0 0.9999788673640744 99.99999999999997 Annotation Cluster 66 Enrichment Score: 0.3145485791312332 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0016021~integral to membrane 165 26.96078431372549 0.044264533579797656 SYT1, OLFR706, 1200009O22RIK, OLFR801, SLC35A3, SLC7A6, SSR1, IL17RB, OLFR805, LPHN3, OLFR691, PTGIR, BC018242, H13, 5330417C22RIK, ADAM2, GRID2, MRGPRB2, SGPL1, TMEFF2, OLFR976, TMEFF1, LNP, SCAMP2, MRGPRB5, PTPRG, SLC33A1, TMIE, LIFR, PNPLA2, VTI1A, OLFR629, OLFR350, KCNT1, DARC, OLFR1472, OLFR1471, VAMP2, NUP43, OLFR1140, OLFR354, DCBLD1, PAQR7, LRIG2, PAQR8, ABCA3, GPR141, CASD1, TMCC2, OLFR1377, SERINC2, OLFR381, VRK2, OLFR45, MTCH2, OLFR382, SLC35F1, STX16, OLFR576, ADAM33, TMEM30B, ADAM30, OLFR1175, OLFR1182, TRPC2, GPR156, PLB1, OLFR895, MRC2, MET, ITGA1, SLC6A14, OLFR304, KCTD3, REEP3, OLFR1518, EPHA4, SEMA6D, DIO2, TOMM70A, CXCL16, ATP2A1, CHRNB3, GOSR2, CHRNB1, SLC36A4, OLFR1161, CLEC14A, GM98, 1190007F08RIK, OLFR845, OLFR1295, GPR161, COX10, CLDN5, GLRA2, 4833423E24RIK, DPY19L3, TMEM62, OLFR1420, OLFR745, SLC1A2, SLC1A3, XYLT2, OLFR741, TAS2R140, OLFR1312, ABHD13, SLC22A5, CALCRL, OLFR1109, OLFR1282, ZDHHC3, STX3, GALNTL2, VEZT, LMBRD2, 4930471M23RIK, RNF170, GRM5, SLC26A5, TLCD1, STXBP5, 4930544O15RIK, TOMM20, NUP107, GRAMD1C, TMCO3, STEAP2, GRAMD1B, TSHR, CLN8, KCNH5, FATE1, NUP160, OLFR1086, CLCNKA, FPR1, OLFR136, GCGR, OLFR435, STT3A, ZDHHC21, GNPTAB, SLC35B4, PCDHB17, LRRTM1, SEC22A, 4932438A13RIK, NSDHL, B4GALNT1, 5730410E15RIK, MS4A4B, HPN, TMEM8, GJB4, OLFR715, OLFR1099, C330027C09RIK, FZD5, OLFR791, OLFR448, TCEB3, ATP6V0A1, OLFR1121 326 5709 12504 1.1085499485797368 0.9999995120194405 0.7662022905141246 45.7321281798322 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 166 27.124183006535947 0.11240635464267952 SYT1, OLFR706, 1200009O22RIK, OLFR801, SLC35A3, SLC7A6, SSR1, IL17RB, OLFR805, LPHN3, OLFR691, PTGIR, BC018242, H13, 5330417C22RIK, ADAM2, GRID2, MRGPRB2, SGPL1, TMEFF2, OLFR976, TMEFF1, LNP, SCAMP2, MRGPRB5, PTPRG, SLC33A1, TMIE, LIFR, PNPLA2, VTI1A, OLFR629, OLFR350, KCNT1, DARC, OLFR1472, OLFR1471, VAMP2, NUP43, OLFR1140, OLFR354, DCBLD1, PAQR7, LRIG2, PAQR8, ABCA3, GPR141, CASD1, TMCC2, OLFR1377, SERINC2, OLFR381, VRK2, OLFR45, MTCH2, OLFR382, SLC35F1, STX16, OLFR576, ADAM33, TMEM30B, ADAM30, OLFR1175, OLFR1182, TRPC2, GPR156, PLB1, OLFR895, MRC2, MET, ITGA1, SLC6A14, OLFR304, KCTD3, REEP3, OLFR1518, EPHA4, SEMA6D, DIO2, TOMM70A, CXCL16, ATP2A1, CHRNB3, GOSR2, CHRNB1, SLC36A4, OLFR1161, CLEC14A, GM98, 1190007F08RIK, OLFR845, OLFR1295, GPR161, COX10, CLDN5, GLRA2, 4833423E24RIK, DPY19L3, TMEM62, OLFR1420, OLFR745, SLC1A2, SLC1A3, XYLT2, OLFR741, TAS2R140, OLFR1312, ABHD13, SLC22A5, CALCRL, OLFR1109, OLFR1282, ZDHHC3, STX3, GALNTL2, VEZT, LMBRD2, 4930471M23RIK, RNF170, GRM5, SLC26A5, TLCD1, STXBP5, 4930544O15RIK, TOMM20, NUP107, GRAMD1C, TMCO3, STEAP2, GRAMD1B, TSHR, CLN8, KCNH5, FATE1, NUP160, OLFR1086, CLCNKA, FPR1, OLFR136, GCGR, OLFR435, STT3A, ZDHHC21, GNPTAB, SLC35B4, PCDHB17, LRRTM1, SEC22A, 4932438A13RIK, NSDHL, B4GALNT1, 5730410E15RIK, MS4A4B, HPN, NTNG1, TMEM8, GJB4, OLFR715, OLFR1099, C330027C09RIK, FZD5, OLFR791, OLFR448, TCEB3, ATP6V0A1, OLFR1121 326 5914 12504 1.0766093142818018 1.0 0.8666195214500325 80.00834093899518 SP_PIR_KEYWORDS transmembrane 155 25.326797385620914 0.2658020031552575 SLC22A17, SYT1, 1200009O22RIK, OLFR801, SLC35A3, SLC7A6, SSR1, IL17RB, OLFR805, LPHN3, OLFR691, PTGIR, BC018242, H13, 5330417C22RIK, ADAM2, GRID2, MRGPRB2, SGPL1, TMEFF2, TMEFF1, SCAMP2, MRGPRB5, LNP, PTPRG, SLC33A1, TMIE, LIFR, PNPLA2, VTI1A, OLFR629, OLFR350, KCNT1, DARC, OLFR1472, OLFR1471, VAMP2, OLFR1140, OLFR354, DCBLD1, PAQR7, LRIG2, PAQR8, ABCA3, GPR141, CASD1, TMCC2, OLFR1377, SERINC2, OLFR381, VRK2, OLFR45, MTCH2, OLFR382, SLC35F1, STX16, OLFR576, ADAM33, TMEM30B, OLFR1175, OLFR1182, TRPC2, GPR156, PLB1, OLFR895, MET, MRC2, ITGA1, SLC6A14, OLFR304, REEP3, OLFR1518, EPHA4, SEMA6D, DIO2, TOMM70A, CXCL16, ATP2A1, CHRNB3, GOSR2, CHRNB1, SLC36A4, OLFR1161, CLEC14A, GM98, 1190007F08RIK, OLFR845, OLFR1295, GPR161, COX10, CLDN5, GLRA2, 4833423E24RIK, DPY19L3, TMEM62, OLFR1420, OLFR745, SLC1A2, SLC1A3, XYLT2, OLFR741, TAS2R140, OLFR1312, ABHD13, SLC22A5, CALCRL, OLFR1109, OLFR1282, ZDHHC3, STX3, GALNTL2, VEZT, LMBRD2, 4930471M23RIK, RNF170, GRM5, SLC26A5, TLCD1, 4930544O15RIK, TOMM20, GRAMD1C, TMCO3, STEAP2, GRAMD1B, TSHR, CLN8, KCNH5, FATE1, OLFR1086, CLCNKA, FPR1, OLFR136, GCGR, OLFR435, STT3A, ZDHHC21, GNPTAB, SLC35B4, PCDHB17, LRRTM1, SEC22A, 4932438A13RIK, NSDHL, B4GALNT1, 5730410E15RIK, HPN, TMEM8, GJB4, OLFR1099, C330027C09RIK, FZD5, OLFR791, OLFR448, ATP6V0A1, OLFR1121 503 5237 17854 1.050549861039985 1.0 0.9162179674839479 98.45699398528586 UP_SEQ_FEATURE transmembrane region 119 19.444444444444446 0.3362143077951721 SYT1, 1200009O22RIK, SLC35A3, SLC7A6, SSR1, IL17RB, LPHN3, PTGIR, BC018242, 5330417C22RIK, H13, ADAM2, GRID2, MRGPRB2, SGPL1, TMEFF2, TMEFF1, MRGPRB5, SCAMP2, LNP, PTPRG, SLC33A1, TMIE, LIFR, PNPLA2, VTI1A, KCNT1, DARC, VAMP2, DCBLD1, PAQR7, PAQR8, LRIG2, ABCA3, GPR141, CASD1, TMCC2, SERINC2, VRK2, MTCH2, STX16, SLC35F1, TMEM30B, ADAM33, GPR156, TRPC2, PLB1, MET, MRC2, ITGA1, SLC6A14, REEP3, EPHA4, SEMA6D, DIO2, TOMM70A, CXCL16, ATP2A1, CHRNB3, GOSR2, CHRNB1, SLC36A4, CLEC14A, GM98, 1190007F08RIK, GPR161, COX10, CLDN5, GLRA2, 4833423E24RIK, DPY19L3, TMEM62, SLC1A2, SLC1A3, XYLT2, TAS2R140, ABHD13, SLC22A5, CALCRL, STX3, ZDHHC3, GALNTL2, VEZT, LMBRD2, 4930471M23RIK, RNF170, GRM5, SLC26A5, TLCD1, 4930544O15RIK, TOMM20, GRAMD1C, TMCO3, STEAP2, TSHR, CLN8, GRAMD1B, KCNH5, FATE1, OLFR1086, CLCNKA, FPR1, GCGR, ZDHHC21, STT3A, GNPTAB, SLC35B4, LRRTM1, SEC22A, 4932438A13RIK, NSDHL, B4GALNT1, 5730410E15RIK, HPN, GJB4, TMEM8, C330027C09RIK, FZD5, ATP6V0A1 444 4113 16021 1.0439865467217764 1.0 0.9998350552564018 99.87205500385097 UP_SEQ_FEATURE topological domain:Cytoplasmic 81 13.23529411764706 0.36608981762349657 SYT1, 1200009O22RIK, GPR161, CLDN5, GLRA2, 4833423E24RIK, SLC35A3, SLC7A6, SSR1, IL17RB, LPHN3, SLC1A2, PTGIR, SLC1A3, 5330417C22RIK, XYLT2, H13, TAS2R140, ADAM2, GRID2, SLC22A5, CALCRL, MRGPRB2, SGPL1, TMEFF2, TMEFF1, STX3, ZDHHC3, MRGPRB5, LNP, SCAMP2, PTPRG, SLC33A1, TMIE, LIFR, GALNTL2, PNPLA2, LMBRD2, VTI1A, GRM5, KCNT1, SLC26A5, DARC, TOMM20, VAMP2, TSHR, KCNH5, DCBLD1, OLFR1086, FPR1, PAQR7, PAQR8, GCGR, GPR141, STT3A, LRRTM1, STX16, SEC22A, ADAM33, B4GALNT1, GPR156, TRPC2, HPN, PLB1, MET, MRC2, ITGA1, SLC6A14, GJB4, TMEM8, FZD5, EPHA4, SEMA6D, TOMM70A, CXCL16, ATP2A1, CHRNB3, ATP6V0A1, GOSR2, CHRNB1, CLEC14A 444 2780 16021 1.0513489208633093 1.0 0.9997765613018187 99.93947758868454 UP_SEQ_FEATURE topological domain:Extracellular 58 9.477124183006536 0.6901548522995242 1200009O22RIK, GPR161, GLRA2, CLDN5, SLC35A3, SLC7A6, IL17RB, LPHN3, SLC1A2, PTGIR, SLC1A3, 5330417C22RIK, TAS2R140, ADAM2, GRID2, CALCRL, SLC22A5, MRGPRB2, TMEFF2, TMEFF1, STX3, MRGPRB5, LNP, SLC33A1, PTPRG, TMIE, LIFR, LMBRD2, GRM5, SLC26A5, KCNT1, DARC, TSHR, DCBLD1, OLFR1086, FPR1, PAQR7, PAQR8, GCGR, GPR141, ADAM33, GPR156, TRPC2, HPN, PLB1, MRC2, MET, SLC6A14, ITGA1, GJB4, TMEM8, FZD5, EPHA4, SEMA6D, CXCL16, CHRNB3, CHRNB1, CLEC14A 444 2174 16021 0.9626648267402638 1.0 0.9999997745357783 99.99999946489042 SP_PIR_KEYWORDS membrane 145 23.692810457516337 0.8671729113048655 SYT1, 1200009O22RIK, ZNRF1, ITSN1, SLC35A3, SLC7A6, SSR1, KIFC3, IL17RB, LPHN3, PTGIR, CHIC1, BC018242, H13, 5330417C22RIK, ADAM2, GRID2, MRGPRB2, SGPL1, TMEFF2, TMEFF1, MRGPRB5, SCAMP2, LNP, PTPRG, SLC33A1, TMIE, LIFR, RPS6KC1, PNPLA2, CTNNA1, VTI1A, KCNT1, DARC, VAMP2, VPS26B, ERC1, DCBLD1, PAQR7, PAQR8, LRIG2, ABCA3, GPR141, CASD1, TMCC2, SERINC2, VRK2, MTCH2, SLC35F1, SNF8, STX16, TMEM30B, ADAM33, RHEBL1, TRPC2, GPR156, PLB1, MET, MRC2, ITGA1, SLC6A14, REEP3, EPHA4, SEMA6D, DIO2, TOMM70A, CXCL16, ATP2A1, CHRNB3, COQ10B, GOSR2, CHRNB1, SLC36A4, CLEC14A, RSC1A1, GM98, 1190007F08RIK, GPR161, COX10, CLDN5, GLRA2, 4833423E24RIK, MITD1, DPY19L3, TMEM62, AP1S3, SLC1A2, SLC1A3, XYLT2, TAS2R140, SYNJ2, ABHD13, SLC22A5, CALCRL, DLG1, JAKMIP1, ZDHHC3, STX3, GALNTL2, VEZT, TCTE3, LMBRD2, 4930471M23RIK, RNF170, GRM5, SLC26A5, TLCD1, STXBP5, ZFYVE28, 4930544O15RIK, TOMM20, GRAMD1C, TMCO3, STEAP2, GRAMD1B, TSHR, CLN8, KCNH5, FATE1, OLFR1086, CLCNKA, FPR1, GCGR, STT3A, ZDHHC21, GNPTAB, SORBS1, SLC35B4, PCDHB17, LRRTM1, SEC22A, 4932438A13RIK, RASA2, NSDHL, B4GALNT1, 5730410E15RIK, HPN, DNM1L, SVEP1, NTNG1, TMEM8, GJB4, C330027C09RIK, FZD5, ATP6V0A1 503 5507 17854 0.934588582541432 1.0 0.9973810970075929 99.99999999985424 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 85 13.88888888888889 0.9171472538861565 SYT1, 1200009O22RIK, GPR161, OVCH2, GLRA2, TMEM62, SLC35A3, SSR1, IL17RB, LPHN3, SLC1A2, PTGIR, BC018242, SLC1A3, 5330417C22RIK, XYLT2, H13, ADAM2, TAS2R140, GRID2, CFH, ABHD13, SLC22A5, CALCRL, MRGPRB2, TMEFF2, TMEFF1, MRGPRB5, PTPRG, SLC33A1, LIFR, GALNTL2, SPINT1, GZME, PNPLA2, LMBRD2, 4930471M23RIK, DNASE2A, SLIT2, GRM5, KCNT1, SLC26A5, DARC, TFPI, COL1A2, FKBP14, TMCO3, TSHR, KCNH5, DCBLD1, OLFR1086, FPR1, LRIG2, GCGR, GPR141, PCSK2, FGG, STT3A, GNPTAB, AGT, RNASET2B, LRRTM1, TMEM30B, ADAM33, B4GALNT1, GPR156, COL18A1, HPN, SVEP1, PLB1, MET, MRC2, NTNG1, ITGA1, SLC6A14, TMEM8, DBC1, FZD5, EPHA4, SEMA6D, CHRNB3, METRNL, CHRNB1, SLC36A4, CLEC14A 444 3444 16021 0.89055845915602 1.0 0.9999999999983973 100.0 SP_PIR_KEYWORDS glycoprotein 88 14.37908496732026 0.9536619795798089 SYT1, 1200009O22RIK, GPR161, OVCH2, GLRA2, TMEM62, SLC35A3, SSR1, IL17RB, LPHN3, SLC1A2, PTGIR, BC018242, SLC1A3, 5330417C22RIK, XYLT2, H13, ADAM2, TAS2R140, GRID2, CFH, ABHD13, SLC22A5, CALCRL, MRGPRB2, TMEFF2, TMEFF1, MRGPRB5, PTPRG, SLC33A1, LIFR, GALNTL2, SPINT1, GZME, PNPLA2, LMBRD2, 4930471M23RIK, DNASE2A, SLIT2, GRM5, KCNT1, SLC26A5, DARC, TFPI, COL1A2, FKBP14, TMCO3, TSHR, DST, KCNH5, DCBLD1, OLFR1086, FPR1, LRIG2, GCGR, GPR141, PCSK2, FGG, STT3A, GNPTAB, SORBS1, AGT, RNASET2B, LRRTM1, TMEM30B, ADAM33, B4GALNT1, COL18A1, GPR156, HPN, SVEP1, PLB1, MET, MRC2, NTNG1, ITGA1, SLC6A14, TMEM8, DBC1, FZD5, EPHA4, SEMA6D, CXCL16, CHRNB3, METRNL, CHRNB1, SLC36A4, CLEC14A 503 3600 17854 0.8676562845151314 1.0 0.9997299881963313 100.0 SP_PIR_KEYWORDS disulfide bond 56 9.15032679738562 0.9774881033011723 GPR161, OVCH2, PGC, GLRA2, CCT3, SLC7A6, LPHN3, PTGIR, 5330417C22RIK, XYLT2, IAPP, ADAM2, CFH, TMEFF2, TMEFF1, RPGR, LIFR, GALNTL2, GZME, SPINT1, SLIT2, DNASE2A, EIF2AK1, DARC, TFPI, TSHR, DCBLD1, OLFR1086, VPREB1, FPR1, LRIG2, GCGR, PCSK2, FGG, GNPTAB, RNASET2B, ADAM33, FCHO2, B4GALNT1, FGFBP3, COL18A1, HPN, SVEP1, MRC2, MET, NTNG1, ITGA1, TMEM8, FZD5, SVAL2, SEMA6D, CXCL16, ATP2A1, CHRNB3, CHRNB1, CLEC14A 503 2469 17854 0.8050715552774885 1.0 0.9999456908224668 100.0 UP_SEQ_FEATURE disulfide bond 51 8.333333333333332 0.9884766968162596 GPR161, OVCH2, PGC, GLRA2, CCT3, LPHN3, PTGIR, 5330417C22RIK, IAPP, ADAM2, CFH, TMEFF2, TMEFF1, RPGR, GALNTL2, LIFR, GZME, SPINT1, SLIT2, DNASE2A, DARC, TFPI, TSHR, DCBLD1, OLFR1086, VPREB1, FPR1, LRIG2, GCGR, PCSK2, FGG, GNPTAB, RNASET2B, ADAM33, FCHO2, B4GALNT1, COL18A1, FGFBP3, HPN, SVEP1, MRC2, ITGA1, NTNG1, TMEM8, FZD5, SEMA6D, CXCL16, ATP2A1, CHRNB3, CHRNB1, CLEC14A 444 2379 16021 0.7735393022278269 1.0 1.0 100.0 UP_SEQ_FEATURE signal peptide 64 10.457516339869281 0.9934103132007593 RARRES2, 1200009O22RIK, PGC, OVCH2, GLRA2, IL17RB, SSR1, LPHN3, 5330417C22RIK, IAPP, ADAM2, CFH, GRID2, CALCRL, TMEFF2, TMEFF1, RPGR, PTPRG, TMIE, LIFR, GZME, SPINT1, CECR5, SLIT2, DNASE2A, 4930471M23RIK, GRM5, TLCD1, FKBP14, COL1A2, TFPI, TMCO3, TSHR, DCBLD1, CCK, VPREB1, LRIG2, GCGR, CASD1, PCSK2, FGG, RNASET2B, AGT, LRRTM1, ADAM33, COL8A2, FGFBP3, COL18A1, SVEP1, PLB1, MET, MRC2, NTNG1, ITGA1, TMEM8, DBC1, FZD5, EPHA4, SEMA6D, CXCL16, CHRNB3, METRNL, CHRNB1, CLEC14A 444 2963 16021 0.7793902576217798 1.0 1.0 100.0 SP_PIR_KEYWORDS signal 64 10.457516339869281 0.9957888458244589 RARRES2, 1200009O22RIK, PGC, OVCH2, GLRA2, IL17RB, SSR1, LPHN3, 5330417C22RIK, IAPP, ADAM2, CFH, GRID2, CALCRL, TMEFF2, TMEFF1, RPGR, PTPRG, TMIE, LIFR, GZME, SPINT1, CECR5, SLIT2, DNASE2A, 4930471M23RIK, GRM5, TLCD1, FKBP14, COL1A2, TFPI, TMCO3, TSHR, DCBLD1, CCK, VPREB1, LRIG2, GCGR, CASD1, PCSK2, FGG, RNASET2B, AGT, LRRTM1, ADAM33, COL8A2, FGFBP3, COL18A1, SVEP1, PLB1, MET, MRC2, NTNG1, ITGA1, TMEM8, DBC1, FZD5, EPHA4, SEMA6D, CXCL16, CHRNB3, METRNL, CHRNB1, CLEC14A 503 2970 17854 0.7648760634844134 1.0 0.999998638247429 100.0 Annotation Cluster 67 Enrichment Score: 0.3070970262092733 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030665~clathrin coated vesicle membrane 3 0.49019607843137253 0.24021926650688777 AP1S3, SYT1, VAMP2 326 36 12504 3.196319018404908 1.0 0.9252593339608977 97.54984551895075 SP_PIR_KEYWORDS cytoplasmic vesicle 9 1.4705882352941175 0.3293118685236279 PCSK2, AP1S3, SYT1, CHIC1, ATP6V0A1, VEZT, VAMP2, ZNRF1, KIFC3 503 232 17854 1.3769623637485433 1.0 0.9457513322970987 99.54513187305334 GOTERM_CC_FAT GO:0030662~coated vesicle membrane 3 0.49019607843137253 0.4023804942900285 AP1S3, SYT1, VAMP2 326 53 12504 2.1710846162750324 1.0 0.9745807158221209 99.90415925611792 GOTERM_CC_FAT GO:0030136~clathrin-coated vesicle 4 0.6535947712418301 0.5101119288905104 AP1S3, SYT1, VAMP2, STEAP2 326 104 12504 1.4752241623407267 1.0 0.984465667070345 99.9934528478817 GOTERM_CC_FAT GO:0030135~coated vesicle 4 0.6535947712418301 0.6294519494626041 AP1S3, SYT1, VAMP2, STEAP2 326 124 12504 1.237284781318029 1.0 0.9887619365661532 99.99984897595772 GOTERM_CC_FAT GO:0030659~cytoplasmic vesicle membrane 3 0.49019607843137253 0.6650565736805125 AP1S3, SYT1, VAMP2 326 87 12504 1.3226147662365138 1.0 0.9895362775687315 99.99996138789705 GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 3 0.49019607843137253 0.7115229799804381 AP1S3, SYT1, VAMP2 326 95 12504 1.211236680658702 1.0 0.9931813832221335 99.99999485889047 GOTERM_CC_FAT GO:0012506~vesicle membrane 3 0.49019607843137253 0.722264163083658 AP1S3, SYT1, VAMP2 326 97 12504 1.1862627284801721 1.0 0.9933622250831532 99.99999691984401 Annotation Cluster 68 Enrichment Score: 0.30646637148268463 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007626~locomotory behavior 9 1.4705882352941175 0.3364483225032167 GRM5, EPHA4, CXCL16, FPR1, ITGA1, SLC22A5, TSHR, CLN8, SLIT2 375 239 13588 1.3644853556485357 1.0 0.9970490507054032 99.89226400530457 SP_PIR_KEYWORDS chemotaxis 3 0.49019607843137253 0.5236847301820686 CXCL16, FPR1, SLIT2 503 62 17854 1.7175014429551723 1.0 0.9713728477244055 99.99551966464831 GOTERM_BP_FAT GO:0006935~chemotaxis 4 0.6535947712418301 0.5808622035098994 CXCL16, FPR1, ITGA1, SLIT2 375 109 13588 1.3297125382262995 1.0 0.9991709277132046 99.99994891293632 GOTERM_BP_FAT GO:0042330~taxis 4 0.6535947712418301 0.5808622035098994 CXCL16, FPR1, ITGA1, SLIT2 375 109 13588 1.3297125382262995 1.0 0.9991709277132046 99.99994891293632 Annotation Cluster 69 Enrichment Score: 0.30585496891663383 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004518~nuclease activity 7 1.1437908496732025 0.2531029477750914 FANCM, SLK, RNASET2B, DICER1, TREX2, WRN, DNASE2A 368 154 13288 1.6413043478260871 1.0 0.9685779472929338 98.50055468313879 SP_PIR_KEYWORDS Endonuclease 3 0.49019607843137253 0.5492293348637924 RNASET2B, DICER1, DNASE2A 503 65 17854 1.6382321455880102 1.0 0.9741095582365272 99.99787129141237 SP_PIR_KEYWORDS nuclease 4 0.6535947712418301 0.550044289990165 RNASET2B, DICER1, TREX2, DNASE2A 503 102 17854 1.3919619537675905 1.0 0.9729643662619222 99.99792266657434 GOTERM_MF_FAT GO:0004519~endonuclease activity 3 0.49019607843137253 0.7818645728632158 RNASET2B, DICER1, DNASE2A 368 103 13288 1.0517095821021527 1.0 0.9994511396223412 99.99999996960871 Annotation Cluster 70 Enrichment Score: 0.2982976899093608 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0019717~synaptosome 5 0.8169934640522877 0.092413967449245 PPFIA2, GRID2, ABI1, VAMP2, ITSN1 326 66 12504 2.90574456218628 0.9999999999999697 0.8570697807051606 72.99459685391462 GOTERM_CC_FAT GO:0005624~membrane fraction 11 1.7973856209150325 0.8591574605282113 PPFIA2, VRK2, STT3A, MET, GRID2, ABI1, VAMP2, STEAP2, ITSN1, RSC1A1, JAKMIP1 326 510 12504 0.8272825694695055 1.0 0.9989289213620735 99.99999999967848 GOTERM_CC_FAT GO:0005626~insoluble fraction 11 1.7973856209150325 0.885298677822646 PPFIA2, VRK2, STT3A, MET, GRID2, ABI1, VAMP2, STEAP2, ITSN1, RSC1A1, JAKMIP1 326 528 12504 0.799079754601227 1.0 0.9993357505531391 99.99999999997989 GOTERM_CC_FAT GO:0000267~cell fraction 12 1.9607843137254901 0.9118198525717749 PPFIA2, VRK2, STT3A, MET, GRID2, MTL5, ABI1, VAMP2, STEAP2, ITSN1, RSC1A1, JAKMIP1 326 596 12504 0.7722649977354141 1.0 0.9995202445297006 99.99999999999942 Annotation Cluster 71 Enrichment Score: 0.2960109222378902 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001890~placenta development 5 0.8169934640522877 0.217930715483542 MET, SPINT1, PBRM1, NSDHL, ARNT 375 87 13588 2.0824521072796935 1.0 0.9946846691077597 98.33497004155466 GOTERM_BP_FAT GO:0001892~embryonic placenta development 3 0.49019607843137253 0.5036333226931543 SPINT1, NSDHL, ARNT 375 61 13588 1.7820327868852461 1.0 0.9988867569900429 99.99914503615516 GOTERM_BP_FAT GO:0001701~in utero embryonic development 7 1.1437908496732025 0.7480614828982484 GINS1, MYO1E, ATP6V0A1, SPINT1, AMD1, NSDHL, ARNT 375 267 13588 0.9499725343320851 1.0 0.9997950774113253 99.99999998939957 GOTERM_BP_FAT GO:0048568~embryonic organ development 6 0.9803921568627451 0.797234556682241 RARG, TMIE, SPINT1, DLG1, NSDHL, ARNT 375 241 13588 0.9021078838174273 1.0 0.9998805385729326 99.9999999997154 Annotation Cluster 72 Enrichment Score: 0.2955742561830624 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS tyrosine-protein kinase 6 0.9803921568627451 0.22804686971269242 EPHA4, NEK1, MET, BMX, TTK, C230081A13RIK 503 116 17854 1.835949818331391 1.0 0.9005314434034984 96.96341802580507 SP_PIR_KEYWORDS ATP 6 0.9803921568627451 0.41989283594366833 EPHA4, NEK1, MET, TTK, MARK3, HELLS 503 151 17854 1.4103985359366977 1.0 0.9583372410015653 99.9358544824809 SP_PIR_KEYWORDS phosphotransferase 5 0.8169934640522877 0.4622990498595148 EPHA4, NEK1, MET, TTK, MARK3 503 124 17854 1.4312512024626436 1.0 0.9638262693219415 99.97698139903034 GOTERM_MF_FAT GO:0004713~protein tyrosine kinase activity 6 0.9803921568627451 0.47548504610559245 EPHA4, NEK1, MET, BMX, TTK, C230081A13RIK 368 164 13288 1.3210498409331919 1.0 0.9923185045134383 99.99073871457317 INTERPRO IPR008266:Tyrosine protein kinase, active site 4 0.6535947712418301 0.5427577265605474 EPHA4, MET, BMX, C230081A13RIK 500 101 17763 1.4069702970297029 1.0 0.9998369124572313 99.99944522713338 SMART SM00219:TyrKc 3 0.49019607843137253 0.8612360588838149 EPHA4, MET, BMX 253 124 9131 0.8731671554252198 1.0 0.9998710788311994 99.99999999803254 INTERPRO IPR001245:Tyrosine protein kinase 3 0.49019607843137253 0.8670208531958349 EPHA4, MET, BMX 500 124 17763 0.8595 1.0 0.9999999145220876 99.99999999999719 Annotation Cluster 73 Enrichment Score: 0.2810368574891725 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001655~urogenital system development 7 1.1437908496732025 0.21473358615270177 SGPL1, RARG, AGT, MYO1E, HELLS, SLIT2, DLG1 375 146 13588 1.7372785388127854 1.0 0.9946076727436637 98.21786396324181 GOTERM_BP_FAT GO:0048705~skeletal system morphogenesis 4 0.6535947712418301 0.6986480929305068 SGPL1, MEF2D, RARG, DLG1 375 130 13588 1.1149128205128205 1.0 0.99966453308308 99.9999997905117 GOTERM_BP_FAT GO:0001501~skeletal system development 5 0.8169934640522877 0.9566013127667885 SGPL1, MEF2D, RARG, PDLIM7, DLG1 375 285 13588 0.6356959064327486 1.0 0.9999993169050085 100.0 Annotation Cluster 74 Enrichment Score: 0.24676766594825636 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00249:PHD 4 0.6535947712418301 0.4615775724661063 TRIM66, A530054K11RIK, PHF16, WHSC1 253 91 9131 1.5864135864135862 1.0 0.9865888896105472 99.95595647853925 INTERPRO IPR001965:Zinc finger, PHD-type 4 0.6535947712418301 0.4729229566728929 TRIM66, A530054K11RIK, PHF16, WHSC1 500 91 17763 1.5615824175824176 1.0 0.9996566820397378 99.99500260940376 INTERPRO IPR019787:Zinc finger, PHD-finger 3 0.49019607843137253 0.6683666752282176 TRIM66, PHF16, WHSC1 500 81 17763 1.3157777777777777 1.0 0.9999853230269621 99.99999613712961 INTERPRO IPR019786:Zinc finger, PHD-type, conserved site 3 0.49019607843137253 0.7061215299145959 TRIM66, PHF16, WHSC1 500 87 17763 1.2250344827586208 1.0 0.999992394727339 99.9999994041476 Annotation Cluster 75 Enrichment Score: 0.2435599326756289 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007292~female gamete generation 4 0.6535947712418301 0.1996865462393401 AGT, PAQR7, PAQR8, NRIP1 375 56 13588 2.5881904761904764 1.0 0.9947887875593134 97.5550264326529 GOTERM_BP_FAT GO:0007276~gamete generation 10 1.6339869281045754 0.562604008634706 AGT, MKKS, MTL5, PAQR7, RAD18, PAQR8, TLK2, B4GALNT1, NRIP1, FANCC 375 331 13588 1.0947029204431018 1.0 0.9991637094067081 99.99989604918316 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 12 1.9607843137254901 0.5747269096623425 TRPC2, AGT, MET, MKKS, MTL5, PAQR7, RAD18, PAQR8, TLK2, B4GALNT1, NRIP1, FANCC 375 409 13588 1.063119804400978 1.0 0.9991664063525204 99.99993491872421 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 12 1.9607843137254901 0.5747269096623425 TRPC2, AGT, MET, MKKS, MTL5, PAQR7, RAD18, PAQR8, TLK2, B4GALNT1, NRIP1, FANCC 375 409 13588 1.063119804400978 1.0 0.9991664063525204 99.99993491872421 GOTERM_BP_FAT GO:0019953~sexual reproduction 11 1.7973856209150325 0.6227028736812926 TRPC2, AGT, MKKS, MTL5, PAQR7, RAD18, PAQR8, TLK2, B4GALNT1, NRIP1, FANCC 375 386 13588 1.032594127806563 1.0 0.9993441177059484 99.9999911412042 GOTERM_BP_FAT GO:0048232~male gamete generation 5 0.8169934640522877 0.9239797531663018 MKKS, MTL5, RAD18, TLK2, B4GALNT1 375 255 13588 0.710483660130719 1.0 0.9999943728035782 100.0 GOTERM_BP_FAT GO:0007283~spermatogenesis 5 0.8169934640522877 0.9239797531663018 MKKS, MTL5, RAD18, TLK2, B4GALNT1 375 255 13588 0.710483660130719 1.0 0.9999943728035782 100.0 Annotation Cluster 76 Enrichment Score: 0.23503929159243225 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006836~neurotransmitter transport 5 0.8169934640522877 0.1783249013911578 SYT1, STX3, SLC6A14, VAMP2, CLN8 375 80 13588 2.264666666666667 1.0 0.9934057327436171 96.20799101127693 GOTERM_BP_FAT GO:0001505~regulation of neurotransmitter levels 3 0.49019607843137253 0.5123148294597952 SYT1, VAMP2, CLN8 375 62 13588 1.753290322580645 1.0 0.9989766176230342 99.99936279685647 GOTERM_BP_FAT GO:0007268~synaptic transmission 4 0.6535947712418301 0.8718857299553873 SYT1, GRID2, VAMP2, CLN8 375 178 13588 0.8142621722846443 1.0 0.999971685522325 99.99999999999987 GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 5 0.8169934640522877 0.8730971007045738 SYT1, GM98, GRID2, VAMP2, CLN8 375 226 13588 0.8016519174041299 1.0 0.9999720674601363 99.99999999999989 GOTERM_BP_FAT GO:0007267~cell-cell signaling 5 0.8169934640522877 0.9605777142220265 SYT1, MET, GRID2, VAMP2, CLN8 375 290 13588 0.6247356321839082 1.0 0.9999995181663374 100.0 Annotation Cluster 77 Enrichment Score: 0.2317525300872157 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060541~respiratory system development 5 0.8169934640522877 0.4461299624984344 RARG, DICER1, PPP3R1, FOXP2, NFIB 375 124 13588 1.4610752688172044 1.0 0.9983092389985286 99.99469029172184 GOTERM_BP_FAT GO:0030324~lung development 4 0.6535947712418301 0.5932416901920816 DICER1, PPP3R1, FOXP2, NFIB 375 111 13588 1.3057537537537538 1.0 0.9992715171726575 99.99996899827126 GOTERM_BP_FAT GO:0030323~respiratory tube development 4 0.6535947712418301 0.6053825788248757 DICER1, PPP3R1, FOXP2, NFIB 375 113 13588 1.2826430678466076 1.0 0.9992563206430642 99.99998128749387 GOTERM_BP_FAT GO:0035295~tube development 7 1.1437908496732025 0.7383578647284398 AGT, DICER1, PPP3R1, ETV4, FOXP2, DLG1, NFIB 375 264 13588 0.9607676767676769 1.0 0.9997816289639618 99.99999998010367 Annotation Cluster 78 Enrichment Score: 0.23051489604634443 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF001630:serpin 3 0.49019607843137253 0.38052775120035054 AGT, SERPINB11, SERPINB9G 203 53 8136 2.26861232456548 1.0 0.9999998629997897 99.75025332021029 GOTERM_MF_FAT GO:0004867~serine-type endopeptidase inhibitor activity 5 0.8169934640522877 0.39285750116825185 AGT, TFPI, SERPINB11, SPINT1, SERPINB9G 368 115 13288 1.5699432892249527 1.0 0.9851807567398708 99.92395795322324 UP_SEQ_FEATURE site:Reactive bond 3 0.49019607843137253 0.42348985005894346 TFPI, SERPINB11, SPINT1 444 52 16021 2.0817307692307696 1.0 0.9998998404569213 99.98706211334046 SMART SM00093:SERPIN 3 0.49019607843137253 0.5720128814346295 AGT, SERPINB11, SERPINB9G 253 69 9131 1.5691699604743083 1.0 0.9933611862040821 99.99749087639407 INTERPRO IPR000215:Protease inhibitor I4, serpin 3 0.49019607843137253 0.5812836450936627 AGT, SERPINB11, SERPINB9G 500 69 17763 1.544608695652174 1.0 0.9999215779563544 99.99985778752438 GOTERM_MF_FAT GO:0004866~endopeptidase inhibitor activity 5 0.8169934640522877 0.6536066936575672 AGT, TFPI, SERPINB11, SPINT1, SERPINB9G 368 161 13288 1.121388063732109 1.0 0.9982725044111861 99.99997637640386 SP_PIR_KEYWORDS Serine protease inhibitor 3 0.49019607843137253 0.675391449062927 TFPI, SERPINB11, SPINT1 503 82 17854 1.2985986519904962 1.0 0.9890520747550465 99.99997470952661 GOTERM_MF_FAT GO:0030414~peptidase inhibitor activity 5 0.8169934640522877 0.7205960574991901 AGT, TFPI, SERPINB11, SPINT1, SERPINB9G 368 176 13288 1.0258152173913042 1.0 0.9988353092211306 99.99999892844994 SP_PIR_KEYWORDS protease inhibitor 3 0.49019607843137253 0.8153994815626192 TFPI, SERPINB11, SPINT1 503 109 17854 0.9769274262680795 1.0 0.9958234679374044 99.99999998759662 GOTERM_MF_FAT GO:0004857~enzyme inhibitor activity 5 0.8169934640522877 0.9071066996308345 AGT, TFPI, SERPINB11, SPINT1, SERPINB9G 368 243 13288 0.7429772767937018 1.0 0.9999283374662858 99.99999999999986 Annotation Cluster 79 Enrichment Score: 0.23007598322414538 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013069:BTB/POZ 5 0.8169934640522877 0.4861356539512013 ZFP295, KLHL13, PATZ1, KLHL24, ZBTB3 500 128 17763 1.387734375 1.0 0.9996828485681917 99.99662533567894 SMART SM00225:BTB 6 0.9803921568627451 0.5578918778721557 ZFP295, KLHL13, PATZ1, KCTD3, KLHL24, ZBTB3 253 180 9131 1.203030303030303 1.0 0.9930826578489047 99.99623737804725 INTERPRO IPR000210:BTB/POZ-like 6 0.9803921568627451 0.5729143434488455 ZFP295, KLHL13, PATZ1, KCTD3, KLHL24, ZBTB3 500 180 17763 1.1842000000000001 1.0 0.9999137687171068 99.99980686474865 UP_SEQ_FEATURE domain:BTB 4 0.6535947712418301 0.6083653725527685 KLHL13, KCTD3, KLHL24, ZBTB3 444 113 16021 1.2772861356932153 1.0 0.999998164559884 99.99997589037109 INTERPRO IPR011333:BTB/POZ fold 5 0.8169934640522877 0.7482700956747479 ZFP295, KLHL13, PATZ1, KCTD3, ZBTB3 500 180 17763 0.9868333333333335 1.0 0.9999960001817022 99.99999994562849 Annotation Cluster 80 Enrichment Score: 0.22705233442615164 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE calcium-binding region:2 5 0.8169934640522877 0.36222202422616145 DGKG, PPP3R1, FKBP14, ITSN1, DST 444 110 16021 1.6401515151515151 1.0 0.999805588998333 99.93318728618739 UP_SEQ_FEATURE calcium-binding region:1 5 0.8169934640522877 0.42488800435172935 DGKG, PPP3R1, FKBP14, ITSN1, DST 444 120 16021 1.5034722222222223 1.0 0.9998913786910631 99.98756282648054 INTERPRO IPR018249:EF-HAND 2 7 1.1437908496732025 0.517410072979496 GNPTAB, DGKG, PPP3R1, FKBP14, ITSN1, DST, TBC1D8B 500 205 17763 1.2130829268292682 1.0 0.9998104823234925 99.99872211274831 SMART SM00054:EFh 5 0.8169934640522877 0.52604680220751 DGKG, PPP3R1, FKBP14, ITSN1, DST 253 137 9131 1.3171864631718646 1.0 0.9921966609728035 99.99103534504948 INTERPRO IPR002048:Calcium-binding EF-hand 5 0.8169934640522877 0.5395131149149033 DGKG, PPP3R1, FKBP14, ITSN1, DST 500 137 17763 1.2965693430656935 1.0 0.999860297869769 99.9993811192573 UP_SEQ_FEATURE domain:EF-hand 2 5 0.8169934640522877 0.6494367642516901 DGKG, PPP3R1, FKBP14, ITSN1, DST 444 160 16021 1.1276041666666667 1.0 0.9999993763115815 99.9999960182406 UP_SEQ_FEATURE domain:EF-hand 1 5 0.8169934640522877 0.6542542126469781 DGKG, PPP3R1, FKBP14, ITSN1, DST 444 161 16021 1.120600414078675 1.0 0.9999993965274531 99.99999682027396 INTERPRO IPR018247:EF-HAND 1 6 0.9803921568627451 0.7104494774926079 GNPTAB, DGKG, PPP3R1, FKBP14, ITSN1, DST 500 211 17763 1.010218009478673 1.0 0.9999924610772744 99.99999952631424 INTERPRO IPR011992:EF-Hand type 5 0.8169934640522877 0.8844744369375669 CBL, PPP3R1, FKBP14, ITSN1, DST 500 227 17763 0.782511013215859 1.0 0.9999999554378473 99.99999999999967 INTERPRO IPR018248:EF hand 3 0.49019607843137253 0.8889230739393094 PPP3R1, ITSN1, DST 500 132 17763 0.807409090909091 1.0 0.9999999616394847 99.99999999999983 Annotation Cluster 81 Enrichment Score: 0.22603805665952198 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001655~urogenital system development 7 1.1437908496732025 0.21473358615270177 SGPL1, RARG, AGT, MYO1E, HELLS, SLIT2, DLG1 375 146 13588 1.7372785388127854 1.0 0.9946076727436637 98.21786396324181 GOTERM_BP_FAT GO:0008285~negative regulation of cell proliferation 8 1.3071895424836601 0.4204606872229022 A130010J15RIK, EIF2AK1, RARG, AGT, CTNNA1, ETV4, DLG1, NFIB 375 224 13588 1.2940952380952382 1.0 0.9981488680582212 99.98870556097889 GOTERM_BP_FAT GO:0001763~morphogenesis of a branching structure 5 0.8169934640522877 0.45223749831187193 AGT, DICER1, SPINT1, ETV4, DLG1 375 125 13588 1.4493866666666668 1.0 0.9984303302414067 99.99558590938653 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 4 0.6535947712418301 0.4738690091093596 AGT, DICER1, ETV4, DLG1 375 93 13588 1.5584802867383512 1.0 0.9985323942970616 99.99774414835339 GOTERM_BP_FAT GO:0048608~reproductive structure development 5 0.8169934640522877 0.4824263836019973 RARG, AGT, SLC22A5, NRIP1, DLG1 375 130 13588 1.3936410256410257 1.0 0.998644050718145 99.99828343911756 GOTERM_BP_FAT GO:0042127~regulation of cell proliferation 16 2.6143790849673203 0.5182092632226706 COL18A1, A130010J15RIK, E2F3, RARG, LIFR, ROGDI, CTNNA1, FOXP2, EIF2AK1, AGT, ADAM33, CALCRL, ETV4, TBX19, NFIB, DLG1 375 538 13588 1.077610904584882 1.0 0.9989639822098384 99.9994796535876 GOTERM_BP_FAT GO:0003006~reproductive developmental process 7 1.1437908496732025 0.7383578647284398 RARG, AGT, MKKS, SLC22A5, NRIP1, DLG1, FANCC 375 264 13588 0.9607676767676769 1.0 0.9997816289639618 99.99999998010367 GOTERM_BP_FAT GO:0035295~tube development 7 1.1437908496732025 0.7383578647284398 AGT, DICER1, PPP3R1, ETV4, FOXP2, DLG1, NFIB 375 264 13588 0.9607676767676769 1.0 0.9997816289639618 99.99999998010367 GOTERM_BP_FAT GO:0060429~epithelium development 7 1.1437908496732025 0.7605928878536437 COL18A1, A130010J15RIK, RARG, AGT, PPP3R1, ETV4, DLG1 375 271 13588 0.9359507995079951 1.0 0.9998095974415336 99.99999999546925 GOTERM_BP_FAT GO:0060562~epithelial tube morphogenesis 3 0.49019607843137253 0.8142531379645751 AGT, ETV4, DLG1 375 111 13588 0.9793153153153153 1.0 0.9999105962349704 99.99999999993395 GOTERM_BP_FAT GO:0035239~tube morphogenesis 4 0.6535947712418301 0.8538172476345005 AGT, DICER1, ETV4, DLG1 375 171 13588 0.8475945419103313 1.0 0.9999575558355899 99.99999999999878 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 4 0.6535947712418301 0.859194127310198 RARG, AGT, ETV4, DLG1 375 173 13588 0.8377957610789981 1.0 0.9999626037549664 99.99999999999935 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 4 0.6535947712418301 0.9616500437769923 RARG, AGT, ETV4, DLG1 375 238 13588 0.608985994397759 1.0 0.9999995557298665 100.0 Annotation Cluster 82 Enrichment Score: 0.21964358700153322 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE topological domain:Lumenal 15 2.450980392156863 0.25520877743856263 SGPL1, ZDHHC3, SCAMP2, GALNTL2, PNPLA2, 4833423E24RIK, SSR1, STT3A, H13, XYLT2, ATP2A1, LRRTM1, SEC22A, ATP6V0A1, B4GALNT1 444 414 16021 1.3073671497584543 1.0 0.9996147231789186 99.16844142254132 GOTERM_CC_FAT GO:0005783~endoplasmic reticulum 18 2.941176470588235 0.8854884406931354 TRPC2, SGPL1, SLC33A1, 4833423E24RIK, MSRB3, SSR1, STT3A, VRK2, H13, XYLT2, ATP2A1, LRRTM1, SEC22A, FKBP14, GOSR2, CLN8, ZFYVE1, DLG1 326 838 12504 0.8238722052213128 1.0 0.9992871019246937 99.99999999998033 SP_PIR_KEYWORDS endoplasmic reticulum 13 2.1241830065359477 0.9704892647308696 SGPL1, SLC33A1, 4833423E24RIK, SSR1, STT3A, H13, XYLT2, ATP2A1, LRRTM1, SEC22A, FKBP14, CLN8, DLG1 503 678 17854 0.6805831676607025 1.0 0.99989837020385 100.0 Annotation Cluster 83 Enrichment Score: 0.21561037034638186 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051348~negative regulation of transferase activity 3 0.49019607843137253 0.4307459752128768 ZFYVE28, MLLT1, CLN8 375 53 13588 2.0510188679245283 1.0 0.998179700434577 99.99161891682695 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 7 1.1437908496732025 0.4685463667410439 SERINC2, DGKG, ZFYVE28, MET, MLLT1, CLN8, DLG1 375 199 13588 1.2745862646566166 1.0 0.9985086376381215 99.99733227261656 GOTERM_BP_FAT GO:0043086~negative regulation of catalytic activity 3 0.49019607843137253 0.770889975669237 ZFYVE28, MLLT1, CLN8 375 101 13588 1.0762772277227723 1.0 0.9998379377017985 99.99999999782192 GOTERM_BP_FAT GO:0044092~negative regulation of molecular function 3 0.49019607843137253 0.8822513214498486 ZFYVE28, MLLT1, CLN8 375 132 13588 0.8235151515151516 1.0 0.9999772067417397 99.99999999999997 Annotation Cluster 84 Enrichment Score: 0.21133148313690456 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 10 1.6339869281045754 0.3690780413160887 SGPL1, MYO1E, VPREB1, ATP6V0A1, ROGDI, PATZ1, NFKB1, TSHR, DNASE2A, HELLS 375 281 13588 1.2894899169632266 1.0 0.9976151644925372 99.95349359596608 GOTERM_BP_FAT GO:0030097~hemopoiesis 9 1.4705882352941175 0.3869622184682111 SGPL1, MYO1E, VPREB1, ATP6V0A1, ROGDI, PATZ1, TSHR, DNASE2A, HELLS 375 251 13588 1.2992509960159362 1.0 0.9978722855610619 99.97119612630127 GOTERM_BP_FAT GO:0002520~immune system development 10 1.6339869281045754 0.4257497744942834 SGPL1, MYO1E, VPREB1, ATP6V0A1, ROGDI, PATZ1, NFKB1, TSHR, DNASE2A, HELLS 375 295 13588 1.2282937853107345 1.0 0.9981690538686064 99.99030545410452 GOTERM_BP_FAT GO:0001775~cell activation 7 1.1437908496732025 0.6746472609839671 FGG, AGT, VPREB1, PATZ1, TSHR, HELLS, DLG1 375 246 13588 1.0310677506775068 1.0 0.9995730143293413 99.99999924902262 GOTERM_BP_FAT GO:0046649~lymphocyte activation 5 0.8169934640522877 0.7752002815281398 VPREB1, PATZ1, TSHR, HELLS, DLG1 375 191 13588 0.9485514834205935 1.0 0.999850171303311 99.99999999841272 GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 3 0.49019607843137253 0.8257557329480206 PATZ1, TSHR, HELLS 375 114 13588 0.9535438596491227 1.0 0.9999229622375627 99.99999999997723 GOTERM_BP_FAT GO:0045321~leukocyte activation 5 0.8169934640522877 0.8570957704565368 VPREB1, PATZ1, TSHR, HELLS, DLG1 375 219 13588 0.8272754946727551 1.0 0.9999609797857382 99.99999999999916 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 3 0.49019607843137253 0.9058062316290224 PATZ1, TSHR, HELLS 375 142 13588 0.7655211267605634 1.0 0.9999891563987642 100.0 Annotation Cluster 85 Enrichment Score: 0.209342017960601 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0015629~actin cytoskeleton 7 1.1437908496732025 0.44136083359867107 PPP1R9A, SORBS1, PDLIM7, MYO1E, TMOD3, CTNNA1, DST 326 205 12504 1.3097112075415234 1.0 0.9743896707033118 99.96144636076019 GOTERM_BP_FAT GO:0007015~actin filament organization 3 0.49019607843137253 0.45876792790855403 PPP1R9A, SORBS1, DLG1 375 56 13588 1.9411428571428573 1.0 0.9984885925573362 99.99638539419713 SMART SM00228:PDZ 5 0.8169934640522877 0.5874499634087177 PPP1R9A, PDLIM7, RAPGEF6, PDZD2, DLG1 253 148 9131 1.2192874692874691 1.0 0.9937677426597412 99.99841370645584 INTERPRO IPR001478:PDZ/DHR/GLGF 5 0.8169934640522877 0.6006964350755898 PPP1R9A, PDLIM7, RAPGEF6, PDZD2, DLG1 500 148 17763 1.200202702702703 1.0 0.999946866973435 99.99993175090191 GOTERM_BP_FAT GO:0030029~actin filament-based process 5 0.8169934640522877 0.7180511965789724 PPP1R9A, SORBS1, PDLIM7, APBB2, DLG1 375 176 13588 1.0293939393939395 1.0 0.9997424280262442 99.99999993087859 GOTERM_BP_FAT GO:0007010~cytoskeleton organization 8 1.3071895424836601 0.7978452232748438 PPP1R9A, SORBS1, PDLIM7, CNTROB, FTCD, DST, CLN8, DLG1 375 326 13588 0.8891942740286298 1.0 0.9998785878878675 99.99999999972935 GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 4 0.6535947712418301 0.8366022702919359 PPP1R9A, SORBS1, PDLIM7, DLG1 375 165 13588 0.8784161616161615 1.0 0.9999376493355544 99.9999999999922 Annotation Cluster 86 Enrichment Score: 0.20481177312893983 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008017~microtubule binding 3 0.49019607843137253 0.5054814245208135 TMOD3, CLASP2, DST 368 61 13288 1.7758374910905201 1.0 0.9942411290535361 99.99603188376163 GOTERM_BP_FAT GO:0051493~regulation of cytoskeleton organization 4 0.6535947712418301 0.5155490469401462 TMOD3, CLASP2, DST, DLG1 375 99 13588 1.464026936026936 1.0 0.9989975196385716 99.99942966011395 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 5 0.8169934640522877 0.6161799560681572 TMOD3, TLK2, CLASP2, DST, DLG1 375 154 13588 1.1764502164502166 1.0 0.9992798912134817 99.9999882131619 GOTERM_MF_FAT GO:0015631~tubulin binding 3 0.49019607843137253 0.6248971016699423 TMOD3, CLASP2, DST 368 76 13288 1.4253432494279175 1.0 0.9977659835659436 99.99992569036851 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 8 1.3071895424836601 0.9428657672063919 CORO2B, SLC26A5, TMOD3, CLASP2, TNNI3, CTNNA1, DST, JAKMIP1 368 414 13288 0.6977525729888678 1.0 0.9999811934794937 100.0 Annotation Cluster 87 Enrichment Score: 0.19938683870217652 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 5 0.8169934640522877 0.3362173494567602 TRPC2, GLRA2, GRID2, CHRNB3, CHRNB1 368 106 13288 1.7032403609515996 1.0 0.9787325690337276 99.7254993829418 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 5 0.8169934640522877 0.3362173494567602 TRPC2, GLRA2, GRID2, CHRNB3, CHRNB1 368 106 13288 1.7032403609515996 1.0 0.9787325690337276 99.7254993829418 GOTERM_BP_FAT GO:0042391~regulation of membrane potential 5 0.8169934640522877 0.4153067655768309 GM98, SLC26A5, GRID2, CHRNB1, DLG1 375 119 13588 1.5224649859943977 1.0 0.9982227390068684 99.98691038976466 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 7 1.1437908496732025 0.7283920869643126 TRPC2, GM98, SLC26A5, GRID2, CHRNB1, TNNI3, DLG1 375 261 13588 0.9718109833971903 1.0 0.9997672925244274 99.99999996291056 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 7 1.1437908496732025 0.7512378493147158 TRPC2, GM98, SLC26A5, GRID2, CHRNB1, TNNI3, DLG1 375 268 13588 0.9464278606965175 1.0 0.9997901268756721 99.99999999141934 GOTERM_BP_FAT GO:0050801~ion homeostasis 7 1.1437908496732025 0.8213839130999403 TRPC2, GM98, SLC26A5, GRID2, CHRNB1, TNNI3, DLG1 375 293 13588 0.865674630261661 1.0 0.9999202752048282 99.9999999999656 GOTERM_BP_FAT GO:0042592~homeostatic process 13 2.1241830065359477 0.8853556392673478 TRPC2, GM98, VPREB1, CIDEA, WRN, POT1B, TNNI3, DNASE2A, SLC26A5, GRID2, CHRNB1, FANCC, DLG1 375 584 13588 0.806593607305936 1.0 0.9999786081023895 99.99999999999997 GOTERM_BP_FAT GO:0019725~cellular homeostasis 7 1.1437908496732025 0.914374015757627 TRPC2, GM98, SLC26A5, GRID2, CHRNB1, TNNI3, DLG1 375 343 13588 0.739482993197279 1.0 0.9999920728287862 100.0 GOTERM_BP_FAT GO:0048878~chemical homeostasis 7 1.1437908496732025 0.9396772204337169 TRPC2, GM98, SLC26A5, GRID2, CHRNB1, TNNI3, DLG1 375 365 13588 0.6949114155251142 1.0 0.9999976813452139 100.0 Annotation Cluster 88 Enrichment Score: 0.186381737471089 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016567~protein ubiquitination 3 0.49019607843137253 0.5460272963678279 GSPT1, RNF2, 4930555K19RIK 375 66 13588 1.6470303030303033 1.0 0.9991618996259214 99.99980681392545 GOTERM_BP_FAT GO:0032446~protein modification by small protein conjugation 3 0.49019607843137253 0.6440361204146559 GSPT1, RNF2, 4930555K19RIK 375 79 13588 1.3760000000000001 1.0 0.9994521554567253 99.99999664076684 GOTERM_BP_FAT GO:0070647~protein modification by small protein conjugation or removal 3 0.49019607843137253 0.7847479834522697 GSPT1, RNF2, 4930555K19RIK 375 104 13588 1.0452307692307692 1.0 0.9998529146319557 99.99999999922974 Annotation Cluster 89 Enrichment Score: 0.18045315274158147 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008219~cell death 15 2.450980392156863 0.5340809612626508 SGPL1, DEDD, CIDEA, GZME, DBC1, NFKB1, DNASE2A, STK3, PURB, BAG4, MEF2D, GSPT1, SLK, CLN8, TRIM39 375 507 13588 1.0720315581854043 1.0 0.9990243826044201 99.99970220517027 GOTERM_BP_FAT GO:0016265~death 15 2.450980392156863 0.5698820069133479 SGPL1, DEDD, CIDEA, GZME, DBC1, NFKB1, DNASE2A, STK3, PURB, BAG4, MEF2D, GSPT1, SLK, CLN8, TRIM39 375 519 13588 1.0472447013487476 1.0 0.9991840435030789 99.9999214003901 SP_PIR_KEYWORDS Apoptosis 9 1.4705882352941175 0.7349208165454504 SGPL1, MEF2D, SLK, DEDD, CIDEA, NFKB1, TRIM39, STK3, DNASE2A 503 337 17854 0.9479384818684333 1.0 0.9925448756975939 99.99999835904748 GOTERM_BP_FAT GO:0006915~apoptosis 12 1.9607843137254901 0.7385283418113849 SGPL1, MEF2D, BAG4, GSPT1, SLK, DEDD, CIDEA, NFKB1, TRIM39, STK3, DNASE2A, PURB 375 465 13588 0.9350881720430108 1.0 0.9997749055586324 99.99999998031855 GOTERM_BP_FAT GO:0012501~programmed cell death 12 1.9607843137254901 0.7581139344009112 SGPL1, MEF2D, BAG4, GSPT1, SLK, DEDD, CIDEA, NFKB1, TRIM39, STK3, DNASE2A, PURB 375 473 13588 0.9192727272727274 1.0 0.9998041172222761 99.99999999462095 Annotation Cluster 90 Enrichment Score: 0.1708919151898736 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 7 1.1437908496732025 0.6473763527359944 AGT, CIDEA, APBB2, ITSN1, CTNNA1, CLN8, HELLS 375 239 13588 1.0612663877266388 1.0 0.9994698315733497 99.99999712905985 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 15 2.450980392156863 0.6647570285927966 COL18A1, RARG, DEDD, CIDEA, WRN, CTNNA1, ITSN1, STK3, BAG4, GSPT1, AGT, GRID2, APBB2, CLN8, HELLS 375 553 13588 0.9828571428571428 1.0 0.9995587258055612 99.99999876320132 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 7 1.1437908496732025 0.6669947535791428 AGT, CIDEA, APBB2, ITSN1, CTNNA1, CLN8, HELLS 375 244 13588 1.0395191256830603 1.0 0.9995638530907269 99.99999889378266 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 7 1.1437908496732025 0.6708350652290942 AGT, CIDEA, APBB2, ITSN1, CTNNA1, CLN8, HELLS 375 245 13588 1.0352761904761905 1.0 0.9995684248798624 99.99999908817084 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 15 2.450980392156863 0.6828194224346245 COL18A1, RARG, DEDD, CIDEA, WRN, CTNNA1, ITSN1, STK3, BAG4, GSPT1, AGT, GRID2, APBB2, CLN8, HELLS 375 560 13588 0.9705714285714286 1.0 0.9996155493183146 99.99999950845346 GOTERM_BP_FAT GO:0010941~regulation of cell death 15 2.450980392156863 0.6903889743249069 COL18A1, RARG, DEDD, CIDEA, WRN, CTNNA1, ITSN1, STK3, BAG4, GSPT1, AGT, GRID2, APBB2, CLN8, HELLS 375 563 13588 0.9653996447602131 1.0 0.9996376857643737 99.99999967130418 GOTERM_BP_FAT GO:0009967~positive regulation of signal transduction 5 0.8169934640522877 0.7011306261337398 FGFBP3, AGT, SHOC2, ITSN1, CTNNA1 375 172 13588 1.0533333333333335 1.0 0.9996712745835572 99.99999981748155 Annotation Cluster 91 Enrichment Score: 0.16892611388062234 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 7 1.1437908496732025 0.39553997245315703 PHIP, GNAL, SLC1A2, SLC1A3, SORBS1, ACADS, STEAP2 375 184 13588 1.3784927536231886 1.0 0.9980261894473489 99.9772230816453 GOTERM_BP_FAT GO:0009725~response to hormone stimulus 4 0.6535947712418301 0.8366022702919359 PHIP, SORBS1, ACADS, STEAP2 375 165 13588 0.8784161616161615 1.0 0.9999376493355544 99.9999999999922 GOTERM_BP_FAT GO:0010033~response to organic substance 10 1.6339869281045754 0.9408323470645408 TRPC2, PHIP, GNAL, SLC1A2, UPF3B, SLC1A3, SORBS1, ACADS, DICER1, STEAP2 375 505 13588 0.7175181518151815 1.0 0.999997706961644 100.0 Annotation Cluster 92 Enrichment Score: 0.16830330365388413 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042803~protein homodimerization activity 6 0.9803921568627451 0.6200726308478306 TRIM66, EIF2AK1, CIDEA, TPD52L1, NFKB1, FOXP2 368 193 13288 1.1225501239017797 1.0 0.9977586092139522 99.99991068494258 GOTERM_MF_FAT GO:0042802~identical protein binding 8 1.3071895424836601 0.6939099362544479 SYT1, TRIM66, EIF2AK1, CLDN5, CIDEA, TPD52L1, NFKB1, FOXP2 368 290 13288 0.9961019490254872 1.0 0.9983522947045886 99.99999601720528 GOTERM_MF_FAT GO:0046983~protein dimerization activity 9 1.4705882352941175 0.726682029000953 TRIM66, EIF2AK1, CIDEA, TPD52L1, NFKB1, PDSS1, STK3, FOXP2, ARNT 368 340 13288 0.9558184143222507 1.0 0.9988858200380101 99.99999921952394 Annotation Cluster 93 Enrichment Score: 0.16194326434891826 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007018~microtubule-based movement 4 0.6535947712418301 0.5290476970638416 KIF7, TCTE3, DST, KIFC3 375 101 13588 1.4350363036303628 1.0 0.999008968538123 99.99964382584356 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 11 1.7973856209150325 0.7380447308543009 KIF7, CEP170, CNTROB, LRRCC1, TTLL4, SMEK1, CLASP2, TCTE3, DST, JAKMIP1, KIFC3 326 450 12504 0.9375869120654396 1.0 0.9943764445512536 99.9999986017423 GOTERM_BP_FAT GO:0007017~microtubule-based process 5 0.8169934640522877 0.8367441692116945 KIF7, CNTROB, TCTE3, DST, KIFC3 375 211 13588 0.8586413902053712 1.0 0.9999336349004274 99.99999999999231 Annotation Cluster 94 Enrichment Score: 0.1537210304007348 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044429~mitochondrial part 18 2.941176470588235 0.20542497749547528 PDK2, ACADSB, ACADS, COX10, BCKDHB, SIRT5, CIDEA, HADHA, PEO1, MTCH2, TOMM70A, PPM1K, IVD, TOMM20, CARS2, MRPL38, PDHX, ABCA12 326 524 12504 1.3175666182737789 1.0 0.9283661880634648 95.5152419272247 GOTERM_CC_FAT GO:0031967~organelle envelope 13 2.1241830065359477 0.7519002342337324 TRPC2, NUP160, COX10, BCKDHB, CIDEA, SIRT5, HADHA, MTCH2, TOMM70A, TOMM20, NUP107, NUP43, ABCA12 326 540 12504 0.9233810497614179 1.0 0.9951403179752859 99.99999932863733 GOTERM_CC_FAT GO:0031975~envelope 13 2.1241830065359477 0.7562978153668427 TRPC2, NUP160, COX10, BCKDHB, CIDEA, SIRT5, HADHA, MTCH2, TOMM70A, TOMM20, NUP107, NUP43, ABCA12 326 542 12504 0.9199737396146966 1.0 0.994854623646572 99.9999994726521 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 9 1.4705882352941175 0.8019270818289395 MTCH2, TOMM70A, COX10, BCKDHB, TOMM20, SIRT5, CIDEA, HADHA, ABCA12 326 391 12504 0.8828707263113301 1.0 0.9966919668098478 99.99999996789596 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 7 1.1437908496732025 0.9204536597022359 MTCH2, TOMM70A, COX10, BCKDHB, TOMM20, HADHA, ABCA12 326 368 12504 0.7295945585489464 1.0 0.9995644491067982 99.99999999999986 GOTERM_CC_FAT GO:0005743~mitochondrial inner membrane 4 0.6535947712418301 0.9844049600215268 MTCH2, BCKDHB, HADHA, ABCA12 326 296 12504 0.5183220029845796 1.0 0.9999926412790072 100.0 GOTERM_CC_FAT GO:0019866~organelle inner membrane 4 0.6535947712418301 0.9888624158493047 MTCH2, BCKDHB, HADHA, ABCA12 326 312 12504 0.491741387446909 1.0 0.9999968364503606 100.0 Annotation Cluster 95 Enrichment Score: 0.1471675357229149 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 4 0.6535947712418301 0.5682480348423748 ADAL, ATP2A1, ATP6V0A1, NME6 375 107 13588 1.3545669781931464 1.0 0.9991898591986732 99.99991627497477 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 4 0.6535947712418301 0.5932416901920816 ADAL, ATP2A1, ATP6V0A1, NME6 375 111 13588 1.3057537537537538 1.0 0.9992715171726575 99.99996899827126 GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 9 1.4705882352941175 0.5941316840796093 DCTD, SLC1A3, ADAL, COX10, ATP2A1, ATP6V0A1, ENOPH1, AMD1, NME6 375 302 13588 1.0798410596026489 1.0 0.9992284357072764 99.99997010922857 GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 4 0.6535947712418301 0.6403445213406447 ADAL, ATP2A1, ATP6V0A1, NME6 375 119 13588 1.217971988795518 1.0 0.9994300221995432 99.99999601075004 GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 4 0.6535947712418301 0.67307939219602 ADAL, ATP2A1, ATP6V0A1, NME6 375 125 13588 1.1595093333333333 1.0 0.9995737559776093 99.99999918639998 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 5 0.8169934640522877 0.7096804040678365 DCTD, ADAL, ATP2A1, ATP6V0A1, NME6 375 174 13588 1.0412260536398468 1.0 0.9997191325650209 99.99999988746146 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 3 0.49019607843137253 0.730096227405749 ATP2A1, ATP6V0A1, NME6 375 93 13588 1.1688602150537635 1.0 0.9997685393133298 99.99999996660284 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 3 0.49019607843137253 0.730096227405749 ATP2A1, ATP6V0A1, NME6 375 93 13588 1.1688602150537635 1.0 0.9997685393133298 99.99999996660284 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 5 0.8169934640522877 0.7302727431536049 DCTD, ADAL, ATP2A1, ATP6V0A1, NME6 375 179 13588 1.012141527001862 1.0 0.9997613541245749 99.99999996696486 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 5 0.8169934640522877 0.7302727431536049 DCTD, ADAL, ATP2A1, ATP6V0A1, NME6 375 179 13588 1.012141527001862 1.0 0.9997613541245749 99.99999996696486 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 4 0.6535947712418301 0.7318587055772937 ADAL, ATP2A1, ATP6V0A1, NME6 375 137 13588 1.0579464720194647 1.0 0.9997620491474037 99.99999997005624 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 3 0.49019607843137253 0.7355128386807606 ATP2A1, ATP6V0A1, NME6 375 94 13588 1.1564255319148935 1.0 0.9997741706157937 99.99999997617542 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 3 0.49019607843137253 0.7408367633636349 ATP2A1, ATP6V0A1, NME6 375 95 13588 1.1442526315789474 1.0 0.9997796174583333 99.99999998302171 GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 3 0.49019607843137253 0.770889975669237 ATP2A1, ATP6V0A1, NME6 375 101 13588 1.0762772277227723 1.0 0.9998379377017985 99.99999999782192 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 3 0.49019607843137253 0.7755934108079181 ATP2A1, ATP6V0A1, NME6 375 102 13588 1.0657254901960784 1.0 0.9998466159697319 99.99999999845835 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 3 0.49019607843137253 0.7935733239266615 ATP2A1, ATP6V0A1, NME6 375 106 13588 1.0255094339622641 1.0 0.9998803806687936 99.99999999961653 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 4 0.6535947712418301 0.8209512497549575 ADAL, ATP2A1, ATP6V0A1, NME6 375 160 13588 0.9058666666666666 1.0 0.9999218946328725 99.99999999996417 GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 3 0.49019607843137253 0.8294455399498727 ATP2A1, ATP6V0A1, NME6 375 115 13588 0.9452521739130435 1.0 0.9999290456945132 99.99999999998406 Annotation Cluster 96 Enrichment Score: 0.1419351238795122 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016044~membrane organization 8 1.3071895424836601 0.6249119587165863 AP1S3, MRC2, 4930555K19RIK, VAMP2, STEAP2, ITSN1, CLN8, DLG1 375 272 13588 1.0657254901960784 1.0 0.9993258763023033 99.99999196684776 SP_PIR_KEYWORDS Endocytosis 3 0.49019607843137253 0.7406691025246029 AP1S3, MRC2, ITSN1 503 93 17854 1.145000961970115 1.0 0.9923100449259661 99.99999877946624 GOTERM_BP_FAT GO:0006897~endocytosis 5 0.8169934640522877 0.7645540977420102 AP1S3, MRC2, 4930555K19RIK, STEAP2, ITSN1 375 188 13588 0.9636879432624114 1.0 0.9998218036333422 99.99999999656876 GOTERM_BP_FAT GO:0010324~membrane invagination 5 0.8169934640522877 0.7645540977420102 AP1S3, MRC2, 4930555K19RIK, STEAP2, ITSN1 375 188 13588 0.9636879432624114 1.0 0.9998218036333422 99.99999999656876 Annotation Cluster 97 Enrichment Score: 0.13741553299475787 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019787~small conjugating protein ligase activity 4 0.6535947712418301 0.6753752453299753 4930524E20RIK, RNF2, UBE2W, 4930555K19RIK 368 125 13288 1.155478260869565 1.0 0.9985189873542575 99.99999071765042 GOTERM_MF_FAT GO:0016881~acid-amino acid ligase activity 5 0.8169934640522877 0.6770607506496099 4930524E20RIK, RNF2, TTLL4, UBE2W, 4930555K19RIK 368 166 13288 1.0876113148245155 1.0 0.9984506842645217 99.99999138768779 GOTERM_MF_FAT GO:0016879~ligase activity, forming carbon-nitrogen bonds 5 0.8169934640522877 0.7843847287386426 4930524E20RIK, RNF2, TTLL4, UBE2W, 4930555K19RIK 368 193 13288 0.9354584365848163 1.0 0.9993996938246028 99.99999997428918 GOTERM_MF_FAT GO:0004842~ubiquitin-protein ligase activity 3 0.49019607843137253 0.7863863411528934 RNF2, UBE2W, 4930555K19RIK 368 104 13288 1.0415969899665551 1.0 0.9993834698208756 99.99999997751878 Annotation Cluster 98 Enrichment Score: 0.1355346396599194 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016791~phosphatase activity 7 1.1437908496732025 0.646699063237594 PPM1D, BC018242, PPM1K, PTPRG, SYNJ2, ENOPH1, CTDSPL2 368 238 13288 1.0620204603580563 1.0 0.9981977868373496 99.99996861195496 SP_PIR_KEYWORDS protein phosphatase 4 0.6535947712418301 0.6599404676461621 PPM1D, PPM1K, PTPRG, CTDSPL2 503 120 17854 1.1831676607024517 1.0 0.9888536753509942 99.9999526188001 GOTERM_BP_FAT GO:0016311~dephosphorylation 4 0.6535947712418301 0.7495084841675024 PPM1D, PPM1K, PTPRG, SYNJ2 375 141 13588 1.0279338061465721 1.0 0.999795358374875 99.99999999036955 GOTERM_MF_FAT GO:0004721~phosphoprotein phosphatase activity 4 0.6535947712418301 0.7952279920813146 PPM1D, PPM1K, PTPRG, CTDSPL2 368 152 13288 0.9502288329519449 1.0 0.999418872728169 99.99999998776512 GOTERM_BP_FAT GO:0006470~protein amino acid dephosphorylation 3 0.49019607843137253 0.8257557329480206 PPM1D, PPM1K, PTPRG 375 114 13588 0.9535438596491227 1.0 0.9999229622375627 99.99999999997723 Annotation Cluster 99 Enrichment Score: 0.13406728642841376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044420~extracellular matrix part 4 0.6535947712418301 0.42970030464172226 COL18A1, SLC1A3, COL1A2, COL8A2 326 92 12504 1.6676447052547345 1.0 0.9728242113567688 99.949044448115 SP_PIR_KEYWORDS hydroxylation 3 0.49019607843137253 0.5408221613222208 COL18A1, COL1A2, COL8A2 503 64 17854 1.663829522862823 1.0 0.9732405950560434 99.99726810490071 INTERPRO IPR008160:Collagen triple helix repeat 3 0.49019607843137253 0.6683666752282176 COL18A1, COL1A2, COL8A2 500 81 17763 1.3157777777777777 1.0 0.9999853230269621 99.99999613712961 SP_PIR_KEYWORDS collagen 3 0.49019607843137253 0.6881789434109742 COL18A1, COL1A2, COL8A2 503 84 17854 1.2676796364669127 1.0 0.9889669768777813 99.9999853003633 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 6 0.9803921568627451 0.8892262151257576 COL18A1, SLC1A3, NTNG1, COL1A2, ADAM33, COL8A2 326 297 12504 0.774865216583008 1.0 0.9993117027502681 99.99999999998744 GOTERM_CC_FAT GO:0031012~extracellular matrix 6 0.9803921568627451 0.9079010876107563 COL18A1, SLC1A3, NTNG1, COL1A2, ADAM33, COL8A2 326 309 12504 0.7447733635118233 1.0 0.9995617986744862 99.99999999999896 SP_PIR_KEYWORDS extracellular matrix 3 0.49019607843137253 0.9839524765216819 COL18A1, COL1A2, COL8A2 503 213 17854 0.49992999747990924 1.0 0.9999732044121968 100.0 GOTERM_CC_FAT GO:0044421~extracellular region part 11 1.7973856209150325 0.996553187331196 COL18A1, PCSK2, FGG, SLC1A3, AGT, CXCL16, NTNG1, COL1A2, ADAM33, COL8A2, SLIT2 326 774 12504 0.5451086698054882 1.0 0.9999998662840344 100.0 Annotation Cluster 100 Enrichment Score: 0.12817763273845093 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cytoskeleton 18 2.941176470588235 0.4685687655182329 PDLIM7, LRRCC1, TTLL4, FTCD, ABI1, CHEK1, SMEK1, CTNNA1, KIFC3, CORO2B, SORBS1, SORBS2, CEP170, CNTROB, TMOD3, CLASP2, DST, JAKMIP1 503 583 17854 1.095901435299012 1.0 0.9621100198105046 99.98035240466035 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 11 1.7973856209150325 0.7380447308543009 KIF7, CEP170, CNTROB, LRRCC1, TTLL4, SMEK1, CLASP2, TCTE3, DST, JAKMIP1, KIFC3 326 450 12504 0.9375869120654396 1.0 0.9943764445512536 99.9999986017423 GOTERM_CC_FAT GO:0044430~cytoskeletal part 16 2.6143790849673203 0.9096967921558404 PDLIM7, MYO1E, LRRCC1, TTLL4, SMEK1, TCTE3, KIFC3, PPP1R9A, KIF7, SORBS1, CEP170, CNTROB, TMOD3, CLASP2, DLG1, JAKMIP1 326 774 12504 0.7928853378988919 1.0 0.9995555660760549 99.9999999999992 GOTERM_CC_FAT GO:0005856~cytoskeleton 21 3.431372549019608 0.9761954662307184 PDLIM7, MYO1E, LRRCC1, TTLL4, ABI1, CHEK1, SMEK1, CTNNA1, TCTE3, KIFC3, CORO2B, PPP1R9A, KIF7, SORBS1, CEP170, CNTROB, TMOD3, CLASP2, DST, DLG1, JAKMIP1 326 1122 12504 0.717889833010728 1.0 0.9999797942353347 100.0 Annotation Cluster 101 Enrichment Score: 0.11971670540156196 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001764~neuron migration 3 0.49019607843137253 0.5780806931326328 CCK, MET, APBB2 375 70 13588 1.5529142857142857 1.0 0.9991887588173621 99.99994296135769 GOTERM_BP_FAT GO:0006928~cell motion 10 1.6339869281045754 0.6848931802094467 SGPL1, EPHA4, CCK, MET, DPYSL5, ITGA1, CLASP2, APBB2, SLIT2, ETV4 375 367 13588 0.9873206176203452 1.0 0.9996057907097896 99.99999955934088 GOTERM_BP_FAT GO:0016477~cell migration 6 0.9803921568627451 0.7942899907400053 SGPL1, CCK, MET, ITGA1, CLASP2, APBB2 375 240 13588 0.9058666666666667 1.0 0.9998787256801522 99.99999999963812 GOTERM_BP_FAT GO:0051674~localization of cell 6 0.9803921568627451 0.8951854984544878 SGPL1, CCK, MET, ITGA1, CLASP2, APBB2 375 284 13588 0.7655211267605634 1.0 0.9999847335373699 100.0 GOTERM_BP_FAT GO:0048870~cell motility 6 0.9803921568627451 0.8951854984544878 SGPL1, CCK, MET, ITGA1, CLASP2, APBB2 375 284 13588 0.7655211267605634 1.0 0.9999847335373699 100.0 Annotation Cluster 102 Enrichment Score: 0.11850398109314639 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010608~posttranscriptional regulation of gene expression 5 0.8169934640522877 0.5847634334891045 EIF2AK1, DICER1, ANKHD1, APBB2, EIF4E2 375 148 13588 1.2241441441441443 1.0 0.9992021274396917 99.99995628312396 GOTERM_BP_FAT GO:0006417~regulation of translation 3 0.49019607843137253 0.7661010196645879 EIF2AK1, ANKHD1, EIF4E2 375 100 13588 1.08704 1.0 0.9998228224287384 99.99999999692564 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 4 0.6535947712418301 0.9845138019405785 EIF2AK1, ANKHD1, EIF4E2, ARNT 375 280 13588 0.5176380952380952 1.0 0.9999999889323502 100.0 Annotation Cluster 103 Enrichment Score: 0.11827776020833651 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060173~limb development 4 0.6535947712418301 0.6403445213406447 LNP, RAX, RARG, DICER1 375 119 13588 1.217971988795518 1.0 0.9994300221995432 99.99999601075004 GOTERM_BP_FAT GO:0048736~appendage development 4 0.6535947712418301 0.6403445213406447 LNP, RAX, RARG, DICER1 375 119 13588 1.217971988795518 1.0 0.9994300221995432 99.99999601075004 GOTERM_BP_FAT GO:0035113~embryonic appendage morphogenesis 3 0.49019607843137253 0.7512105003385082 LNP, RARG, DICER1 375 97 13588 1.120659793814433 1.0 0.9997969537101419 99.99999999140361 GOTERM_BP_FAT GO:0030326~embryonic limb morphogenesis 3 0.49019607843137253 0.7512105003385082 LNP, RARG, DICER1 375 97 13588 1.120659793814433 1.0 0.9997969537101419 99.99999999140361 GOTERM_BP_FAT GO:0035107~appendage morphogenesis 3 0.49019607843137253 0.8294455399498727 LNP, RARG, DICER1 375 115 13588 0.9452521739130435 1.0 0.9999290456945132 99.99999999998406 GOTERM_BP_FAT GO:0035108~limb morphogenesis 3 0.49019607843137253 0.8294455399498727 LNP, RARG, DICER1 375 115 13588 0.9452521739130435 1.0 0.9999290456945132 99.99999999998406 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 7 1.1437908496732025 0.9335320445035772 LNP, RARG, RNF2, TMIE, DICER1, SPINT1, DLG1 375 359 13588 0.7065255338904365 1.0 0.9999968842770018 100.0 Annotation Cluster 104 Enrichment Score: 0.10548878475737533 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006508~proteolysis 29 4.738562091503268 0.5651804968384395 OVCH2, PGC, ZNRF1, CNOT4, PCSK2, TRIM65, CUL2, 4930524E20RIK, ADAM2, USP38, CFH, FBXO44, ADAM33, PREPL, ADAM30, USP34, HPN, CBL, GZME, 4930555K19RIK, HLTF, TINAG, ASB8, RNF2, KLHL13, RAD18, RNF138, UBE2W, RSC1A1 375 1034 13588 1.0162527401676338 1.0 0.999172840896183 99.9999057934898 GOTERM_MF_FAT GO:0004175~endopeptidase activity 12 1.9607843137254901 0.617995473505403 PCSK2, HPN, H13, OVCH2, PGC, ADAM2, PREPL, ADAM33, GZME, ADAM30, TINAG, RSC1A1 368 421 13288 1.029226479396881 1.0 0.9978538099698191 99.99990339388395 UP_SEQ_FEATURE active site:Charge relay system 6 0.9803921568627451 0.6432420063170429 PCSK2, HPN, OVCH2, PREPL, GZME, ABHD13 444 198 16021 1.0934343434343434 1.0 0.999999321403861 99.99999470660744 SP_PIR_KEYWORDS zymogen 6 0.9803921568627451 0.6619376210139288 PCSK2, OVCH2, PGC, ADAM33, GZME, AMD1 503 199 17854 1.0702019041529716 1.0 0.9884750020922239 99.9999562407909 SP_PIR_KEYWORDS Serine protease 5 0.8169934640522877 0.6810464092997652 PCSK2, HPN, OVCH2, PREPL, GZME 503 164 17854 1.0821655433254134 1.0 0.9885902873036639 99.99998005139831 GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 5 0.8169934640522877 0.7705079476763452 PCSK2, HPN, OVCH2, PREPL, GZME 368 189 13288 0.9552564987347596 1.0 0.9994355103071572 99.99999993690771 UP_SEQ_FEATURE domain:Peptidase S1 3 0.49019607843137253 0.8160937892532032 HPN, OVCH2, GZME 444 111 16021 0.9752252252252253 1.0 0.9999999980045695 99.99999999988887 GOTERM_MF_FAT GO:0008233~peptidase activity 15 2.450980392156863 0.8325726419851311 HPN, OVCH2, PGC, SPINT1, GZME, TINAG, PCSK2, H13, ADAM2, USP38, PREPL, ADAM33, ADAM30, USP34, RSC1A1 368 629 13288 0.8610976705605862 1.0 0.9996461659397083 99.99999999932535 GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 5 0.8169934640522877 0.8413905505779722 PCSK2, HPN, OVCH2, PREPL, GZME 368 212 13288 0.8516201804757998 1.0 0.9996788554028877 99.99999999969033 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 5 0.8169934640522877 0.8440061085101761 PCSK2, HPN, OVCH2, PREPL, GZME 368 213 13288 0.8476219636660544 1.0 0.9996795169597542 99.99999999975624 SP_PIR_KEYWORDS Protease 12 1.9607843137254901 0.8514968088051731 PCSK2, HPN, H13, OVCH2, PGC, USP38, PREPL, ADAM33, GZME, SPINT1, ADAM30, USP34 503 509 17854 0.8368179918524218 1.0 0.9968971132919882 99.99999999934272 GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 14 2.287581699346405 0.8562082337685841 HPN, PGC, OVCH2, GZME, TINAG, PCSK2, H13, ADAM2, USP38, PREPL, ADAM33, ADAM30, USP34, RSC1A1 368 603 13288 0.8383445093373711 1.0 0.9997013083826102 99.99999999992451 INTERPRO IPR001314:Peptidase S1A, chymotrypsin 3 0.49019607843137253 0.9136101932916711 HPN, OVCH2, GZME 500 143 17763 0.7453006993006992 1.0 0.9999999923345405 100.0 INTERPRO IPR018114:Peptidase S1/S6, chymotrypsin/Hap, active site 3 0.49019607843137253 0.9282273622719129 HPN, OVCH2, GZME 500 151 17763 0.7058145695364237 1.0 0.999999997340782 100.0 SMART SM00020:Tryp_SPc 3 0.49019607843137253 0.9371845852389636 HPN, OVCH2, GZME 253 159 9131 0.6809605488850772 1.0 0.9999919675878903 99.9999999999999 INTERPRO IPR001254:Peptidase S1 and S6, chymotrypsin/Hap 3 0.49019607843137253 0.9404882994788792 HPN, OVCH2, GZME 500 159 17763 0.6703018867924527 1.0 0.9999999992138408 100.0 Annotation Cluster 105 Enrichment Score: 0.10416610473716306 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051338~regulation of transferase activity 7 1.1437908496732025 0.4685463667410439 SERINC2, DGKG, ZFYVE28, MET, MLLT1, CLN8, DLG1 375 199 13588 1.2745862646566166 1.0 0.9985086376381215 99.99733227261656 GOTERM_BP_FAT GO:0051347~positive regulation of transferase activity 4 0.6535947712418301 0.7226744636677497 SERINC2, DGKG, MET, DLG1 375 135 13588 1.0736197530864198 1.0 0.9997604290802715 99.99999994752116 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 5 0.8169934640522877 0.7572417569005114 DGKG, ZFYVE28, MET, MLLT1, DLG1 375 186 13588 0.9740501792114696 1.0 0.9998064299484056 99.99999999428853 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 5 0.8169934640522877 0.7786638712320384 DGKG, ZFYVE28, MET, MLLT1, DLG1 375 192 13588 0.9436111111111112 1.0 0.9998382970664926 99.99999999877453 GOTERM_BP_FAT GO:0045860~positive regulation of protein kinase activity 3 0.49019607843137253 0.859612429271968 DGKG, MET, DLG1 375 124 13588 0.8766451612903225 1.0 0.9999618856613444 99.99999999999937 GOTERM_BP_FAT GO:0033674~positive regulation of kinase activity 3 0.49019607843137253 0.8769301941178183 DGKG, MET, DLG1 375 130 13588 0.8361846153846154 1.0 0.9999734594700841 99.99999999999993 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 6 0.9803921568627451 0.904947470968007 EIF2AK1, DGKG, ZFYVE28, MET, MLLT1, DLG1 375 290 13588 0.7496827586206897 1.0 0.999989070612554 100.0 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 6 0.9803921568627451 0.9208037028249311 EIF2AK1, DGKG, ZFYVE28, MET, MLLT1, DLG1 375 301 13588 0.7222857142857143 1.0 0.9999936629516948 100.0 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 6 0.9803921568627451 0.9208037028249311 EIF2AK1, DGKG, ZFYVE28, MET, MLLT1, DLG1 375 301 13588 0.7222857142857143 1.0 0.9999936629516948 100.0 Annotation Cluster 106 Enrichment Score: 0.10068653952846483 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:TPR 1 4 0.6535947712418301 0.7014159288076709 FKBP5, TOMM70A, SMG7, ACAD11 444 130 16021 1.1102564102564103 1.0 0.9999998364132785 99.9999997068498 UP_SEQ_FEATURE repeat:TPR 2 4 0.6535947712418301 0.7014159288076709 FKBP5, TOMM70A, SMG7, ACAD11 444 130 16021 1.1102564102564103 1.0 0.9999998364132785 99.9999997068498 INTERPRO IPR001440:Tetratricopeptide TPR-1 3 0.49019607843137253 0.7508201275546791 FKBP5, TOMM70A, ACAD11 500 95 17763 1.1218736842105264 1.0 0.9999958367106654 99.99999995354987 SP_PIR_KEYWORDS tpr repeat 4 0.6535947712418301 0.761968330352842 FKBP5, TOMM70A, SMG7, ACAD11 503 141 17854 1.0069512005978314 1.0 0.9929468286412719 99.99999961624361 SMART SM00028:TPR 3 0.49019607843137253 0.8199196910264456 FKBP5, TOMM70A, ACAD11 253 112 9131 0.9667207792207791 1.0 0.9997653622652074 99.99999994909766 INTERPRO IPR019734:Tetratricopeptide repeat 3 0.49019607843137253 0.8266884083335263 FKBP5, TOMM70A, ACAD11 500 112 17763 0.9515892857142857 1.0 0.999999642834203 99.99999999983082 INTERPRO IPR013026:Tetratricopeptide region 3 0.49019607843137253 0.8340984116645199 FKBP5, TOMM70A, ACAD11 500 114 17763 0.9348947368421053 1.0 0.9999997132136199 99.99999999991392 UP_SEQ_FEATURE repeat:TPR 3 3 0.49019607843137253 0.8417903512295777 FKBP5, TOMM70A, ACAD11 444 118 16021 0.9173728813559323 1.0 0.999999999386936 99.99999999999038 INTERPRO IPR011990:Tetratricopeptide-like helical 3 0.49019607843137253 0.926536784439008 FKBP5, TOMM70A, ACAD11 500 150 17763 0.71052 1.0 0.9999999973413947 100.0 Annotation Cluster 107 Enrichment Score: 0.09831218516196286 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060537~muscle tissue development 4 0.6535947712418301 0.7272967817690059 DICER1, MET, FOXP2, DLG1 375 136 13588 1.0657254901960784 1.0 0.9997694259904645 99.99999996033843 GOTERM_BP_FAT GO:0035295~tube development 7 1.1437908496732025 0.7383578647284398 AGT, DICER1, PPP3R1, ETV4, FOXP2, DLG1, NFIB 375 264 13588 0.9607676767676769 1.0 0.9997816289639618 99.99999998010367 GOTERM_BP_FAT GO:0007517~muscle organ development 4 0.6535947712418301 0.8669351267160752 DICER1, MET, FOXP2, DLG1 375 176 13588 0.8235151515151515 1.0 0.999969026933392 99.99999999999974 GOTERM_BP_FAT GO:0014706~striated muscle tissue development 3 0.49019607843137253 0.868532527973546 DICER1, MET, FOXP2 375 127 13588 0.8559370078740158 1.0 0.9999698591970202 99.99999999999979 Annotation Cluster 108 Enrichment Score: 0.09780503526372723 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007155~cell adhesion 14 2.287581699346405 0.7764062044243476 COL18A1, SVEP1, CLDN5, ITGA1, TMEM8, VEZT, CTNNA1, SORBS1, AGT, ADAM2, PCDHB17, COL8A2, DST, DLG1 375 561 13588 0.9042519310754605 1.0 0.9998394559845071 99.99999999854877 GOTERM_BP_FAT GO:0022610~biological adhesion 14 2.287581699346405 0.7785025147203942 COL18A1, SVEP1, CLDN5, ITGA1, TMEM8, VEZT, CTNNA1, SORBS1, AGT, ADAM2, PCDHB17, COL8A2, DST, DLG1 375 562 13588 0.9026429418742586 1.0 0.9998428928387841 99.99999999875956 SP_PIR_KEYWORDS cell adhesion 9 1.4705882352941175 0.8418522504123133 COL18A1, SVEP1, ADAM2, PCDHB17, ITGA1, TMEM8, CTNNA1, DST, COL8A2 503 380 17854 0.8406717589201631 1.0 0.9964402358790346 99.99999999846294 Annotation Cluster 109 Enrichment Score: 0.096657276797274 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001701~in utero embryonic development 7 1.1437908496732025 0.7480614828982484 GINS1, MYO1E, ATP6V0A1, SPINT1, AMD1, NSDHL, ARNT 375 267 13588 0.9499725343320851 1.0 0.9997950774113253 99.99999998939957 GOTERM_BP_FAT GO:0043009~chordate embryonic development 10 1.6339869281045754 0.8239895350766081 GINS1, MYO1E, ATP6V0A1, SPINT1, VEZT, ABI1, AMD1, DLG1, NSDHL, ARNT 375 421 13588 0.8606809184481394 1.0 0.9999213056744126 99.99999999997307 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 10 1.6339869281045754 0.8320878483732346 GINS1, MYO1E, ATP6V0A1, SPINT1, VEZT, ABI1, AMD1, DLG1, NSDHL, ARNT 375 425 13588 0.8525803921568628 1.0 0.9999325412119229 99.99999999998771 Annotation Cluster 110 Enrichment Score: 0.09561662496185468 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006091~generation of precursor metabolites and energy 7 1.1437908496732025 0.7283920869643126 PPP1R3C, COX10, OGDHL, ATP6V0A1, 4833423E24RIK, STEAP2, DHTKD1 375 261 13588 0.9718109833971903 1.0 0.9997672925244274 99.99999996291056 GOTERM_BP_FAT GO:0006006~glucose metabolic process 4 0.6535947712418301 0.745185084580128 PDK2, PPP1R3C, OGDHL, DHTKD1 375 140 13588 1.0352761904761905 1.0 0.9997947213525293 99.99999998719251 GOTERM_BP_FAT GO:0019318~hexose metabolic process 4 0.6535947712418301 0.8482624637334725 PDK2, PPP1R3C, OGDHL, DHTKD1 375 169 13588 0.8576252465483235 1.0 0.999950119141184 99.99999999999773 GOTERM_BP_FAT GO:0005996~monosaccharide metabolic process 4 0.6535947712418301 0.9002722795243234 PDK2, PPP1R3C, OGDHL, DHTKD1 375 191 13588 0.7588411867364747 1.0 0.999987605235752 100.0 Annotation Cluster 111 Enrichment Score: 0.09193619291562852 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051969~regulation of transmission of nerve impulse 3 0.49019607843137253 0.7978652341953317 GRM5, GM98, SLC1A3 375 107 13588 1.0159252336448599 1.0 0.9998745808647197 99.9999999997298 GOTERM_BP_FAT GO:0044057~regulation of system process 5 0.8169934640522877 0.8079658316154242 GRM5, GM98, SLC1A3, ATP2A1, TNNI3 375 201 13588 0.9013598673300167 1.0 0.9998994099489643 99.99999999988496 GOTERM_BP_FAT GO:0031644~regulation of neurological system process 3 0.49019607843137253 0.8219944483884932 GRM5, GM98, SLC1A3 375 113 13588 0.9619823008849558 1.0 0.9999190790976539 99.99999999996749 Annotation Cluster 112 Enrichment Score: 0.091787878184185 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS SH2 domain 3 0.49019607843137253 0.7899538329855285 CBL, BMX, BCAR3 503 103 17854 1.0338358200312687 1.0 0.9945801161262494 99.99999992909268 SMART SM00252:SH2 3 0.49019607843137253 0.8160220163616007 CBL, BMX, BCAR3 253 111 9131 0.9754299754299754 1.0 0.9997892200613155 99.99999993350094 INTERPRO IPR000980:SH2 motif 3 0.49019607843137253 0.8228729355367349 CBL, BMX, BCAR3 500 111 17763 0.9601621621621622 1.0 0.9999996815553217 99.99999999976306 Annotation Cluster 113 Enrichment Score: 0.08318014545675464 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 11 1.7973856209150325 0.7380447308543009 KIF7, CEP170, CNTROB, LRRCC1, TTLL4, SMEK1, CLASP2, TCTE3, DST, JAKMIP1, KIFC3 326 450 12504 0.9375869120654396 1.0 0.9943764445512536 99.9999986017423 SP_PIR_KEYWORDS microtubule 5 0.8169934640522877 0.8721059782690391 KIF7, CEP170, CLASP2, JAKMIP1, KIFC3 503 221 17854 0.8030549733274561 1.0 0.9975247069521527 99.99999999991256 GOTERM_CC_FAT GO:0005874~microtubule 5 0.8169934640522877 0.8745962603656462 KIF7, CEP170, CLASP2, JAKMIP1, KIFC3 326 240 12504 0.799079754601227 1.0 0.9991666523024737 99.99999999993294 Annotation Cluster 114 Enrichment Score: 0.08067472628889713 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE topological domain:Extracellular 58 9.477124183006536 0.6901548522995242 1200009O22RIK, GPR161, GLRA2, CLDN5, SLC35A3, SLC7A6, IL17RB, LPHN3, SLC1A2, PTGIR, SLC1A3, 5330417C22RIK, TAS2R140, ADAM2, GRID2, CALCRL, SLC22A5, MRGPRB2, TMEFF2, TMEFF1, STX3, MRGPRB5, LNP, SLC33A1, PTPRG, TMIE, LIFR, LMBRD2, GRM5, SLC26A5, KCNT1, DARC, TSHR, DCBLD1, OLFR1086, FPR1, PAQR7, PAQR8, GCGR, GPR141, ADAM33, GPR156, TRPC2, HPN, PLB1, MRC2, MET, SLC6A14, ITGA1, GJB4, TMEM8, FZD5, EPHA4, SEMA6D, CXCL16, CHRNB3, CHRNB1, CLEC14A 444 2174 16021 0.9626648267402638 1.0 0.9999997745357783 99.99999946489042 GOTERM_CC_FAT GO:0005886~plasma membrane 67 10.947712418300654 0.910632418017389 SLC22A17, SYT1, GPR161, GLRA2, CLDN5, MITD1, ITSN1, ZNRF1, SLC7A6, IL17RB, AP1S3, LPHN3, CHIC1, SLC1A2, PTGIR, SLC1A3, GRID2, SLC22A5, CALCRL, DLG1, TMEFF1, STX3, LIFR, PNPLA2, VEZT, CTNNA1, GRM5, GNAL, KCNT1, SLC26A5, STXBP5, VAMP2, STEAP2, TSHR, DST, OLFR1086, VPREB1, FPR1, PAQR7, PAQR8, ABI1, LRIG2, GCGR, ABCA3, GPR141, SORBS1, RASA2, RHEBL1, GPR156, TRPC2, MS4A4B, HPN, PLB1, CBL, MET, NTNG1, SLC6A14, ITGA1, GJB4, TMEM8, KCTD3, FZD5, EPHA4, CHRNB3, CHRNB1, PDZD2, RSC1A1 326 2906 12504 0.8843222611140902 1.0 0.9995358892716462 99.99999999999932 SP_PIR_KEYWORDS cell membrane 41 6.699346405228758 0.9113520367322674 GPR161, OLFR1086, GLRA2, CLDN5, FPR1, PAQR7, LRIG2, PAQR8, GCGR, SLC7A6, GPR141, IL17RB, LPHN3, PTGIR, CHIC1, SORBS1, GRID2, SLC22A5, CALCRL, DLG1, RHEBL1, RASA2, GPR156, TMEFF1, PLB1, NTNG1, LIFR, GJB4, VEZT, PNPLA2, CTNNA1, FZD5, GRM5, SLC26A5, KCNT1, STXBP5, CHRNB3, CHRNB1, STEAP2, TSHR, RSC1A1 503 1713 17854 0.8495599665289059 1.0 0.9989752114353846 99.99999999999937 Annotation Cluster 115 Enrichment Score: 0.07249839939778513 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RRM 3 0.49019607843137253 0.7633070616274061 ALKBH8, SYNJ2, CNOT4 444 99 16021 1.0934343434343434 1.0 0.9999999858001526 99.99999999328197 SMART SM00360:RRM 5 0.8169934640522877 0.8419710842481359 ALKBH8, MSI2, SYNJ2, CNOT4, RBM26 253 212 9131 0.8512006861063466 1.0 0.9998454343768421 99.9999999900313 INTERPRO IPR000504:RNA recognition motif, RNP-1 5 0.8169934640522877 0.8502043299446531 ALKBH8, MSI2, SYNJ2, CNOT4, RBM26 500 212 17763 0.8378773584905661 1.0 0.9999998576326106 99.99999999998226 INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 5 0.8169934640522877 0.8527316667212932 ALKBH8, UPF3B, MSI2, CNOT4, RBM26 500 213 17763 0.833943661971831 1.0 0.9999998557509411 99.99999999998637 SP_PIR_KEYWORDS rna-binding 10 1.6339869281045754 0.9314849501892627 KRR1, ALKBH8, RNMT, DICER1, MSI2, NUFIP1, SYNJ2, EIF4E2, CNOT4, RBM26 503 485 17854 0.7318562849705889 1.0 0.9993997408576358 99.99999999999997 Annotation Cluster 116 Enrichment Score: 0.051885514262930525 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048568~embryonic organ development 6 0.9803921568627451 0.797234556682241 RARG, TMIE, SPINT1, DLG1, NSDHL, ARNT 375 241 13588 0.9021078838174273 1.0 0.9998805385729326 99.9999999997154 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 7 1.1437908496732025 0.9335320445035772 LNP, RARG, RNF2, TMIE, DICER1, SPINT1, DLG1 375 359 13588 0.7065255338904365 1.0 0.9999968842770018 100.0 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 3 0.49019607843137253 0.9389189659730227 RARG, TMIE, DLG1 375 161 13588 0.6751801242236025 1.0 0.9999976375934088 100.0 Annotation Cluster 117 Enrichment Score: 0.050374688014058616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Lectin 4 0.6535947712418301 0.8523579497213399 LPHN3, MRC2, GALNTL2, CLEC14A 503 167 17854 0.8501803549957738 1.0 0.9967816727491188 99.99999999939236 GOTERM_MF_FAT GO:0005529~sugar binding 4 0.6535947712418301 0.8804833922000992 LPHN3, MRC2, GALNTL2, CLEC14A 368 181 13288 0.7979822243574346 1.0 0.9998285678000921 99.99999999999473 GOTERM_MF_FAT GO:0030246~carbohydrate binding 6 0.9803921568627451 0.9408767812467296 FGFBP3, LPHN3, MRC2, GALNTL2, CFH, CLEC14A 368 317 13288 0.6834453435742697 1.0 0.9999802808311725 100.0 Annotation Cluster 118 Enrichment Score: 0.049162517054963537 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00248:ANK 5 0.8169934640522877 0.8688396733921384 TRPC2, ASB8, ANKIB1, NFKB1, ANKHD1 253 223 9131 0.8092132083163474 1.0 0.9998768991553569 99.99999999902631 SP_PIR_KEYWORDS ank repeat 5 0.8169934640522877 0.8743156993217533 TRPC2, ASB8, ANKIB1, NFKB1, ANKHD1 503 222 17854 0.7994376085827378 1.0 0.9975156194386627 99.99999999993089 INTERPRO IPR002110:Ankyrin 5 0.8169934640522877 0.8760723670128039 TRPC2, ASB8, ANKIB1, NFKB1, ANKHD1 500 223 17763 0.7965470852017938 1.0 0.9999999336836196 99.99999999999906 UP_SEQ_FEATURE repeat:ANK 2 4 0.6535947712418301 0.9017356319991958 TRPC2, ASB8, ANKIB1, NFKB1 444 191 16021 0.7556719022687609 1.0 0.9999999999934193 100.0 UP_SEQ_FEATURE repeat:ANK 1 4 0.6535947712418301 0.9017356319991958 TRPC2, ASB8, ANKIB1, NFKB1 444 191 16021 0.7556719022687609 1.0 0.9999999999934193 100.0 UP_SEQ_FEATURE repeat:ANK 3 3 0.49019607843137253 0.9369545681959403 TRPC2, ASB8, NFKB1 444 159 16021 0.6808176100628931 1.0 0.9999999999998943 100.0 Annotation Cluster 119 Enrichment Score: 0.04883835002963089 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 4 0.6535947712418301 0.7969162292886527 RARG, RNF2, YY1, ABI1 375 153 13588 0.9473115468409585 1.0 0.999883434622479 99.99999999970787 GOTERM_BP_FAT GO:0003002~regionalization 4 0.6535947712418301 0.9369622054115317 RARG, RNF2, YY1, ABI1 375 214 13588 0.6772834890965732 1.0 0.9999974706851789 100.0 GOTERM_BP_FAT GO:0007389~pattern specification process 5 0.8169934640522877 0.9557629817800165 RAX, RARG, RNF2, YY1, ABI1 375 284 13588 0.6379342723004695 1.0 0.9999992855840427 100.0 Annotation Cluster 120 Enrichment Score: 0.04670249978275076 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003924~GTPase activity 4 0.6535947712418301 0.6908759867171372 GNAL, DNM1L, GSPT1, GUF1 368 128 13288 1.1283967391304348 1.0 0.9983791701385312 99.9999954097377 GOTERM_MF_FAT GO:0005525~GTP binding 7 1.1437908496732025 0.9294382737708736 GNAL, DNM1L, GSPT1, DOCK8, GUF1, DOCK6, RHEBL1 368 354 13288 0.7140137558339474 1.0 0.9999668705266864 100.0 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 7 1.1437908496732025 0.9389914375267951 GNAL, DNM1L, GSPT1, DOCK8, GUF1, DOCK6, RHEBL1 368 363 13288 0.6963109354413702 1.0 0.999979533502703 100.0 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 7 1.1437908496732025 0.9389914375267951 GNAL, DNM1L, GSPT1, DOCK8, GUF1, DOCK6, RHEBL1 368 363 13288 0.6963109354413702 1.0 0.999979533502703 100.0 UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 5 0.8169934640522877 0.9475293369407187 GNAL, DNM1L, GSPT1, GUF1, RHEBL1 444 274 16021 0.6584549878345498 1.0 0.9999999999999676 100.0 SP_PIR_KEYWORDS gtp-binding 5 0.8169934640522877 0.9777963721096556 GNAL, DNM1L, GSPT1, GUF1, RHEBL1 503 313 17854 0.5670132559276926 1.0 0.9999432956105117 100.0 Annotation Cluster 121 Enrichment Score: 0.042753901864213115 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034470~ncRNA processing 4 0.6535947712418301 0.8143428225258822 KRR1, INTS7, DICER1, TRPT1 375 158 13588 0.9173333333333333 1.0 0.9999077934179939 99.99999999993447 GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 4 0.6535947712418301 0.9197302463048356 KRR1, INTS7, CARS2, TRPT1 375 202 13588 0.7175181518151814 1.0 0.9999934908132455 100.0 GOTERM_BP_FAT GO:0006396~RNA processing 6 0.9803921568627451 0.9937349228731585 KRR1, RNMT, INTS7, DICER1, TRPT1, PRPF4 375 437 13588 0.49750114416475977 1.0 0.9999999997646293 100.0 Annotation Cluster 122 Enrichment Score: 0.03775429375824304 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 5 0.8169934640522877 0.9137257710132323 COL18A1, RARG, DEDD, APBB2, STK3 375 248 13588 0.7305376344086022 1.0 0.9999920771768882 100.0 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 5 0.8169934640522877 0.9167743919009257 COL18A1, RARG, DEDD, APBB2, STK3 375 250 13588 0.7246933333333334 1.0 0.9999928198905463 100.0 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 5 0.8169934640522877 0.9197266503292505 COL18A1, RARG, DEDD, APBB2, STK3 375 252 13588 0.718941798941799 1.0 0.9999937257482978 100.0 Annotation Cluster 123 Enrichment Score: 0.03753000813901108 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006461~protein complex assembly 5 0.8169934640522877 0.8752524888567983 FGG, COX10, ATP6V0A1, TAF9, PDSS1 375 227 13588 0.7981204111600588 1.0 0.9999725508223352 99.99999999999991 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 5 0.8169934640522877 0.8752524888567983 FGG, COX10, ATP6V0A1, TAF9, PDSS1 375 227 13588 0.7981204111600588 1.0 0.9999725508223352 99.99999999999991 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 7 1.1437908496732025 0.9074769956603909 FGG, COX10, DICER1, ATP6V0A1, TAF9, PDSS1, HELLS 375 338 13588 0.7504220907297832 1.0 0.9999896891918668 100.0 GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 4 0.6535947712418301 0.9407021163781242 FGG, COX10, DICER1, HELLS 375 217 13588 0.6679201228878648 1.0 0.9999977722100405 100.0 GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 7 1.1437908496732025 0.9416106062294329 FGG, COX10, DICER1, ATP6V0A1, TAF9, PDSS1, HELLS 375 367 13588 0.6911244323342417 1.0 0.9999977565606107 100.0 GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 4 0.6535947712418301 0.9669280409749788 FGG, COX10, DICER1, HELLS 375 245 13588 0.5915863945578231 1.0 0.9999997271103593 100.0 Annotation Cluster 124 Enrichment Score: 0.02544362839676555 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0020037~heme binding 3 0.49019607843137253 0.9109893891702495 CYP2G1, EIF2AK1, 4833423E24RIK 368 144 13288 0.7522644927536232 1.0 0.9999347506699406 99.99999999999993 GOTERM_MF_FAT GO:0046906~tetrapyrrole binding 3 0.49019607843137253 0.9241070818434817 CYP2G1, EIF2AK1, 4833423E24RIK 368 151 13288 0.717391304347826 1.0 0.9999593577129832 99.99999999999999 GOTERM_MF_FAT GO:0005506~iron ion binding 4 0.6535947712418301 0.9963994929093489 CYP2G1, EIF2AK1, 4833423E24RIK, STEAP2 368 343 13288 0.42109266066675116 1.0 0.9999999984806417 100.0 Annotation Cluster 125 Enrichment Score: 0.022503816837761207 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS prenylation 3 0.49019607843137253 0.9177480219355338 PTGIR, RPGR, RHEBL1 503 145 17854 0.7343799273325564 1.0 0.9991183818657413 99.99999999999977 UP_SEQ_FEATURE propeptide:Removed in mature form 4 0.6535947712418301 0.9451837126072719 PTGIR, RPGR, NTNG1, RHEBL1 444 220 16021 0.6560606060606061 1.0 0.9999999999999604 100.0 SP_PIR_KEYWORDS methylation 3 0.49019607843137253 0.9868448138007745 PTGIR, RPGR, RHEBL1 503 221 17854 0.4818329839964737 1.0 0.9999808111943576 100.0 Annotation Cluster 126 Enrichment Score: 0.021087730418809705 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 8 1.3071895424836601 0.9428657672063919 CORO2B, SLC26A5, TMOD3, CLASP2, TNNI3, CTNNA1, DST, JAKMIP1 368 414 13288 0.6977525729888678 1.0 0.9999811934794937 100.0 SP_PIR_KEYWORDS actin-binding 4 0.6535947712418301 0.955188204322032 CORO2B, TMOD3, TNNI3, DST 503 226 17854 0.6282306163021868 1.0 0.9997355833561221 100.0 GOTERM_MF_FAT GO:0003779~actin binding 5 0.8169934640522877 0.9598381113361096 CORO2B, TMOD3, TNNI3, CTNNA1, DST 368 288 13288 0.626887077294686 1.0 0.9999945977897523 100.0 Annotation Cluster 127 Enrichment Score: 0.01949147334996733 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005764~lysosome 3 0.49019607843137253 0.9481990719878025 ZNRF1, 4930471M23RIK, DNASE2A 326 178 12504 0.6464465430481837 1.0 0.9998610006976278 100.0 GOTERM_CC_FAT GO:0000323~lytic vacuole 3 0.49019607843137253 0.9493267494616185 ZNRF1, 4930471M23RIK, DNASE2A 326 179 12504 0.6428351098467971 1.0 0.99985864386589 100.0 GOTERM_CC_FAT GO:0005773~vacuole 3 0.49019607843137253 0.9709801144993343 ZNRF1, 4930471M23RIK, DNASE2A 326 204 12504 0.5640562973655721 1.0 0.9999673512523681 100.0 Annotation Cluster 128 Enrichment Score: 0.012870397386906061 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR008957:Fibronectin, type III-like fold 3 0.49019607843137253 0.9695200289129292 EPHA4, PTPRG, LIFR 500 187 17763 0.5699358288770053 1.0 0.9999999999931697 100.0 SMART SM00060:FN3 3 0.49019607843137253 0.9705405100478948 EPHA4, PTPRG, LIFR 253 191 9131 0.5668729176582579 1.0 0.9999995544328536 100.0 INTERPRO IPR003961:Fibronectin, type III 3 0.49019607843137253 0.9723404543543692 EPHA4, PTPRG, LIFR 500 191 17763 0.5579999999999999 1.0 0.9999999999958045 100.0 Annotation Cluster 129 Enrichment Score: 2.8997428113106924E-4 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013106:Immunoglobulin V-set 4 0.6535947712418301 0.9980572236208645 9830107B12RIK, VPREB1, GM1418, LRIG2 500 364 17763 0.3903956043956044 1.0 1.0 100.0 INTERPRO IPR013783:Immunoglobulin-like fold 6 0.9803921568627451 0.9999461059365484 9830107B12RIK, VPREB1, GM1418, NFAT5, NFKB1, LRIG2 500 644 17763 0.33098757763975156 1.0 1.0 100.0 INTERPRO IPR007110:Immunoglobulin-like 4 0.6535947712418301 0.9999954901716969 9830107B12RIK, VPREB1, GM1418, LRIG2 500 604 17763 0.23527152317880792 1.0 1.0 100.0