Natural Disruption of Two Regulatory Networks in Serotype M3 Group A Streptococcus Isolates Contributes to the Virulence Factor Profile of This Hypervirulent Serotype

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  Fig. S1. Alignment of the rivR gene from the clinical strains MGAS2221 and MGAS10870. Fig. S2. RivR amino acid alignment between strains MGAS2221 and 10870rivR^+1bp. Fig. S3. Analysis of mga and rivR mRNA levels between M1 and M3 GAS isolates containing different plasmid-encoded rivR alleles. Fig. S4. Alignment of the nucleotides upstream of the grab and hasA mRNAs in strains MGAS2221 and MGAS10870. Table S1. Table of primers and probes used in this study. Table S2. Clinical GAS isolates used in this study.

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