Additional file 1: Table S1: Clinical data for osteosarcoma samples and control samples;;;;;;;;;;;;
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Sample name;Sample type;Sample origin;Patient age (years)/sex;Subtype;Grade;Sample location;Chemotherapy;Status;Follow up (months);ATCC number;Provider;Note
OS7;Tumor;Prim;26/M;Obl;4;Femur;Yes;NED;198;-;The Norwegian Radium Hospital;
OS14;Tumor;Prim;14/F;Obl/fbl;4;Femur;Yes;DD;13;-;The Norwegian Radium Hospital;
OS41;Tumor;Prim;11/M;Obl;4;Tibia;No;NA;NA;-;The Norwegian Radium Hospital;
OS48;Tumor;Prim;50/M;Obl/fbl;4;Tibia;No;NED;63;-;The Norwegian Radium Hospital;
OS75;Tumor;Prim;16/M;Obl/tel;4;Costa;No;DD;5;-;The Norwegian Radium Hospital;
OS90;Tumor;Prim;32/M;NA;4;Head/neck;No;DUC;17;-;The Norwegian Radium Hospital;
OS91;Tumor;Prim;79/M;NA;4;Femur;No;DD;8;-;The Norwegian Radium Hospital;
OS93;Tumor;Prim;75/F;NA;4;Scalpula;No;DD;12;-;The Norwegian Radium Hospital;
OS95;Tumor;Prim;74/F;NA;4;Upper trunk;No;DD;45;-;The Norwegian Radium Hospital;
OS96;Tumor;Met;42/M;NA;4;Lung;Yes;DD;36;-;The Norwegian Radium Hospital;
OS97;Tumor;Prim;12/M;Obl/cho;4;Femur;No;DD;23;-;The Norwegian Radium Hospital;
OS98;Tumor;Prim;64/M;NA;4;Pelvis;No;DD;13;-;The Norwegian Radium Hospital;
OS99;Tumor;Prim;33/M;Obl;4;Pelvis;No;DD;21;-;The Norwegian Radium Hospital;
OS3x;Tumor;Prim;17/M;Obl/cho;4;Femur;No;DD;45;-;The Norwegian Radium Hospital;
OS4x;Tumor;Prim;15/M;Obl;4;Femur;Yes;DD;37;-;The Norwegian Radium Hospital;
OS5x;Tumor;Prim;14/M;Obl;4;NA;No;DD;4;-;The Norwegian Radium Hospital;
OS6x;Tumor;Prim;7/M;Obl/tel;4;Femur;Yes;DD;33;-;The Norwegian Radium Hospital;
OS8x;Tumor;Met;16/M;Obl;4;Lung;Yes;DD;19;-;The Norwegian Radium Hospital;
OS9x;Tumor;Prim;67/F;Obl;4;Femur;No;DD;38;-;The Norwegian Radium Hospital;
OS12x;Tumor;Met;41/M;Obl/cho;4;Lung;Yes;DD;49;-;The Norwegian Radium Hospital;
OS13x;Tumor;Met;18/M;Cho;4;Lung;Yes;DD;187;-;The Norwegian Radium Hospital;
OS15x;Tumor;Prim;49/F;Obl;4;Costa;No;DD;3;-;The Norwegian Radium Hospital;
OS16x;Tumor;Prim;34/M;Obl;3;Fibula;No;DD;7;-;The Norwegian Radium Hospital;
OS45x;Tumor;Met;41/F;Fbl;4;Lung;No;DD;1;-;The Norwegian Radium Hospital;
OS56x;Tumor;Prim;8/M;Obl/fbl;4;Humerus;No;NED;63;-;The Norwegian Radium Hospital;
OS58x;Tumor;Prim;31/M;Obl/fbl;4;Femur;No;DD;9;-;The Norwegian Radium Hospital;
OS83x;Tumor;Prim;18/M;Obl;4;Tibia;No;DD;19;-;The Norwegian Radium Hospital;
OS87x;Tumor;Prim;11/F;NA;4;Femur;No;NED;53;-;The Norwegian Radium Hospital;
46-161x;Tumor;Prim;9/F;Obl;4;Tibial;Yes;DD;24;-;Dep of Pathology, University of Valencia;
84-151x;Tumor;Prim;17/M;Obl;4;Femur;Yes;DD;3;-;Dep of Pathology, University of Valencia;
88-191x;Tumor;Prim;NA;Cho;2;NA;NA;NA;NA;-;Dep of Pathology, University of Valencia;
100-81x;Tumor;Prim;NA;SC;4;NA;NA;NA;NA;-;Dep of Pathology, University of Valencia;
154-171x;Tumor;Prim;NA;Obl;4;NA;NA;NA;NA;-;Dep of Pathology, University of Valencia;
166-101x;Tumor;Prim;50/F;Cho;3;Tibial;Yes;DD;11;-;Dep of Pathology, University of Valencia;
221-231x;Tumor;Rec;40/M;Obl;4;Femur;Yes;DD;28;-;Dep of Pathology, University of Valencia;
339-61x;Tumor;Met;21/M;Obl;4;Femur;Yes;DD;18;-;Dep of Pathology, University of Valencia;
399-101x;Tumor;Prim;22/M;Obl;4;Costal;Yes;DD;15;-;Dep of Pathology, University of Valencia;
400-31x;Tumor;Prim;27/F;Obl;4;Pelvic;Yes;DD;19;-;Dep of Pathology, University of Valencia;
8-191x;Tumor;NA;NA;Ost Pleo;4;Knee;Yes;NA;9;-;Dep of Pathology, University of Valencia;
143B;Cell line;NA;13/F;Mixed;NA;NA;-;NA;-;CRL-8303;ATCC;
CAL 72;Cell line;Prim;10/M;Obl;NA;NA;-;NA;-;-;University College London;
G-292;Cell line;NA;9/F;Fbl;NA;NA;-;NA;-;CRL-1423;ATCC;
HAL;Cell line;BM;15/M;NA;NA;NA;-;NA;-;-;The Norwegian Radium Hospital;
HOS;Cell line;NA;13/F;Fbl/epi;NA;NA;-;NA;-;CRL-1543;ATCC;
IOR/MOS;Cell line;Prim;13/F;Obl;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;
IOR/OS10;Cell line;Prim;10/F;Fbl/epi;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;
IOR/OS14;Cell line;Prim;13/M;Obl;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;
IOR/OS15;Cell line;Prim;12/F;Obl;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;
IOR/OS18;Cell line;Met;33/M;Obl;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;
IOR/OS9;Cell line;Met;15/M;Obl;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;
IOR/SARG;Cell line;Prim;25/M;NA;NA;NA;-;NA;-;-;Istituto Ortopedico Rizzoli;Derived from HOS
KPD;Cell line;Prim;7/M;Obl/tel;NA;NA;-;NA;-;-;The Norwegian Radium Hospital;
MG-63;Cell line;NA;14/M;Fbl/epi;NA;NA;-;NA;-;CRL-1427;ATCC;
MHM;Cell line;Met;41/F;Fbl;NA;NA;-;NA;-;-;The Norwegian Radium Hospital;Derived from HOS
MNNG/HOS;Cell line;NA;13/F;NA;NA;NA;-;NA;-;CRL-1547;ATCC;
OHS;Cell line;Prim;14/M;Obl;NA;NA;-;NA;-;-;The Norwegian Radium Hospital;
OSA(SJSA-1);Cell line;NA;19/M;Fbl;NA;NA;-;NA;-;CRL-2098;ATCC;
Saos-2;Cell line;NA;11/F;Epi;NA;NA;-;NA;-;HTB-85;ATCC;
U-2 OS;Cell line;NA;15/F;Epi;NA;NA;-;NA;-;HTB-96;ATCC;
ZK-58;Cell line;NA;21/M;Obl;NA;NA;-;NA;-;-;Heinrich-Heine-Universität Düsseldorf;
Bone 1;Control;-;52/M;-;-;Femur, cortical bone;-;-;-;-;The Norwegian Radium Hospital;Bone from cancer renis patient, bone metastasis
Bone 2;Control;-;20/M;-;-;Tibia;-;-;-;-;The Norwegian Radium Hospital;Bone from patient with osteosarcoma (Parosteal, periosteal)
Bone 3;Control;-;26/M;-;-;NA;-;-;-;-;Capital Biosciences;NA
Bone 4;Control;-;72/F;-;-;NA;-;-;-;-;Capital Biosciences;NA
Bone 5;Control;-;10/M;-;-;Fibula;-;-;-;-;The Norwegian Radium Hospital;Bone from patient with osteosarcoma
Bone 6;Control;-;15/F;-;-;Tibia;-;-;-;-;University College London;Bone from patient with osteosarcoma (osteoblastic)
Bone 7;Control;-;4/F;-;-;Clavicle;-;-;-;-;The Norwegian Radium Hospital;Bone from patient with Giant cell tumour of bone
OB 1 ;Control;-;NA;-;-;-;-;-;-;-;ScienCell Research Laboratories;
OB 2;Control;-;NA;-;-;-;-;-;-;-;ScienCell Research Laboratories;
HEPM;Control;-;Fetus/F;Fbl;-;-;-;-;-;CRL-1486;ATCC;
iMSC#3;Control;BM;NA;-;-;-;-;-;-;-;The Norwegian Radium Hospital;Non-tumorigenic bone-marrow derived cell line
hFOB;Control;-;Fetus/NA;Obl;-;-;-;-;-;CRL-11372;ATCC;
Abbreviations: OS: Osteosarcoma, OB: Osteoblast, NA: Not available, Prim: Primary, Met: Metastasis, Rec: Recurrence BM: Bone marrow, M: Male, F: Female, Obl: Osteoblastic, Fbl: Fibroblastic, Cho: Chondroblastic, Tel: Telangiectatic, Pleo: Pleomorphic, Epi: Epithelial, SC: small cell, NED: Not evidence of disease, DD: Dead of disease, DUC: Dead of unkown cause;;;;;;;;;;;;