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{"sheet":"Supp Table 1","index":0,"n_rows":24,"n_cols":6,"rows_kept":24,"cut":false,"hidden":false,"merged":[]}
[]
["Supplementary Table 1. Potent Ku86/XRCC5-binding proteins."]
[]
[" + indicated proteins that were co-immunoprecipitated with FIR. "]
["Proteins indicated by bold letters were confirmed by western blot."]
["PARP1, DNA-PKcs(PIKK), DDX17 are potent Ku86-binding proteins."]
[]
[]
[]
["FBP","-","-","+","+","Transcriptional factor"]
["TRRAP(PIKK)","+","+","-","-","Transcriptional factor"]
["Filamin A","+","+","-","-","DNA damage related cytoskelton protein"]
["PP1","-","-","+","+","Protein phosphatase"]
["SAP155","+","-","+","+","Splicing factor"]
["IGF2BP1/IMP1","-","-","+","+","RNA stabilizer "]
["/CDR-BP"]
["PARP1","+","+","-","-","DNA repair, NHEJ (accurate)"]
["DNA-PKcs (PIKK)","+","-","-","-","DNA repair, NHEJ (accurate), PIKKs"]
["DDX17","-","-","+","+","DEAD box protein, RNA Nuclear export"]
["DDX5 (Dbp5)","-","-","+","+","DEAD box protein, RNA Nuclear export"]
["DDX24","+","+","-","-","DEAD box protein, RNA Nuclear export"]
["DDX31","+","+","-","-","DEAD box protein, RNA Nuclear export"]
["DDX50","+","+","-","-","DEAD box protein, RNA Nuclear export"]
["DDX54","+","+","-","-","DEAD box protein, RNA Nuclear export"]

{"sheet":"Supp Table 2","index":1,"n_rows":27,"n_cols":4,"rows_kept":27,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 2. Antibodies lists used in this study."]
["Primary antibodies","Company","catalog#","use"]
["anti-c-Myc (9E10)","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-40","WB,IP,IF,IHC,ELISA"]
["anti-FBP","Gift from Dr D Levens",null,"WB,IF,FC"]
["anti-FIR (Total FIRs 6B4)","see Materials and Methods",null,"WB,IF,FC"]
["anti-FIR (Polyclonal E23)","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-133583","WB,IP,ELISA"]
["anti-SAP130","Novus Biologicals(USA,CO)","NB100-1077","ELISA,WB"]
["anti-SAP155","MBL (Nagoya,Japan)","D221-3","WB,IP"]
["anti-P27Kip1","BD Transduction Laboratories (Tokyo,Japan)",610241,"WB,IP"]
["anti-cyclinE","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-247","WB"]
["anti-cdk2","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-163","WB,IP,IF,ELISA"]
["anti-DNA-PKcs","BD biosciences",556456,"WB,IP"]
["anti-Ku86","Bio Matrix Research","BMR00445","WB,IP,ICC,FC"]
["anti-Ku70","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-12729","WB,IP,IF"]
["anti-phospho Erk1/2","Cell signaling Technology Inc.(Danvers,MA)","#4370","WB,IP,IHC,IF,FC"]
["PARP-1","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-8007","WB,IP,IF,ELISA"]
["RAS","Merck Millipore (upstate, USA)","#05-516","WB,IP,IHC,FC,ELISA"]
["BAX","abcam(Tokyo,Japan)","ab7977","IP,WB,IHC"]
["anti-TFIIH/P89","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-293","WB,IP,IF"]
["anti-gammaH2AX","abcam (Tokyo, Japan)","ab2893","WB,IP,IF,IHC"]
["β-actin","Santa Cruz Biotechnology Inc.(Santa Cruz,CA)","sc-1615","WB,IP,IF,FC"]
[]
["Secondary antibodies","Company"]
["α-rabbit/HRP","ECL (amersham Pharmacia)"]
["α-mouse /HRP","DAKO (Tokyo, Japan)"]
["α-goat /HRP","Molecular Probes, Invitrogen (Tokyo, Japan)"]
[null,"IF:immunofluorescence"]

{"sheet":"Supp Table 3","index":2,"n_rows":8,"n_cols":5,"rows_kept":8,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 3. siRNAs used in this study."]
["Oligo Name","Name","siRNA ID","Sequence:(5'-3')","size"]
["Hs_XRCC5_9411_s\nHs_XRCC5_9411_as","Ku86 (XRCC5)","SASI_Hs01_00099411","5'rCrCUUrCrArArGrArGrArArArGUrGrGrArATT\n5'UUrCrCrArCUUUrCUrCUUrGrArArGrGTT","21\n21"]
["Hs_XRCC5_9412_s\nHs_XRCC5_9412_as","Ku86 (XRCC5)","SASI_Hs01_00099412","5'rCrGrArGUrArArCrCrArGrCUrCrAUrArArATT\n5'UUUrAUrGrArGrCUrGrGUUrArCUrCrGTT","21\n21"]
["Hs_XRCC6_0122_s\nHs_XRCC6_0122_as","Ku70 (XRCC6)","SASI_Hs01_00070122","5'rGrArCrAUrGrAUrGrGrGrCrCrArCrGrGrAUTT\n5'rAUrCrCrGUrGrGrCrCrCrAUrCrAUrGUrCTT","21\n21"]
["Hs_XRCC6_1917_s\nHs_XRCC6_1917_as","Ku70 (XRCC6)","SASI_Hs02_00331917","5'rGUUrCUrAUrGrGUrArCrCrGrArGrArArATT\n5'UUUrCUrCrGrGUrArCrCrAUrArGrArArCTT","21\n21"]
["Hs_SF3B1-1_s\nHs_SF3B1-1_as","SAP155","SASI_Hs01_00076712","5'rCrGrArGUUUrGrCUUrGrGUrCrArGrArATT\n5'UUrCUrGrArCrCrArArGrCrArArArCUrCrGTT","21\n21"]
["Hs-FIR-4467-s             Hs-FIR-4467-as","FIR","SASI_Hs01_00104467","5'rCrArGUrGrAUrGrGUUrCUrGrCrGrCrArATT\n5'UUrGrCrGrCrArGrArArCrCrAUrCrArCUrGTT","21\n21"]