Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia

bio.20147641 Supplementary Material

Files in this Data Supplement:

  • Supplementary Material - Yongjun Fan et al. doi: 10.1242/bio.20147641
  • Movie 1 - Movie 1. Representative time-lapse movie showing peroxisomes in a control-derived ONS cell. Example of peroxisomes moving within cells. Compressing the images into this movie format severely reduces image quality. Peroxisomes are green dots. Most show vibratory, Brownian-like motion while some show bursts of rapid, saltatory microtubule-based movement. The movie was captured for duration of 2 minutes at 2 second intervals.
  • Movie 2 - Movie 2. Representative time-lapse movie showing peroxisomes in a HSP patient-derived ONS cell. Example of peroxisomes moving within cells. Compressing the images into this movie format severely reduces image quality. Peroxisomes are green dots. Most show vibratory, Brownian-like motion while some show bursts of rapid, saltatory microtubule-based movement. The movie was captured for duration of 2 minutes at 2 second intervals.