Ascidians: an invertebrate chordate model to study Alzheimer’s disease pathogenesis

DMM003434 Supplementary Material

Files in this Data Supplement:

• Supplemental Figure S1 -

  Fig. S1. Amino acid comparison between C. intestinalis Bace (CiBace) and human BACE1 and BACE2. CiBace is 31.5% identical and 58% similar to human BACE1, and 29.9% identical and 55% similar to BACE2. The region containing the characteristic D(T/S)G motif of the aspartic proteases is conserved in CiBace and indicated (boxed).

• Supplemental Figure S2 -

  Fig. S2. Primers utilized for the generation of the APP₆₉₅ and A β_1-42 expression constructs.