>Acinetobacter_sp. -------------------AGUGCAUGU-GGUGGAUG-CCU-UGGCA-GUC-A--GAGGC GAUGAAAGACGUGAU-AGCCUGCGAAAAGCUCCGGGGAGGCGGCAAAUA-UCCUUU-GAU CCGGAGAUGUCUGAAUGGGGGAACCCACCUACUUU------------------AA----- ---------------GG------------------------------------------- -----------------------------------UA-GGUA-------------UUG-C AACAU--------------------------GAAUACAU-A------------------- ---------------GUGUU-GCAAGGCGA-ACGAGGGGAAGUGAAACAUCUCAGUACCC --UUAGGAAAAGAAAUCAA-UUGAGAUUCCCUCAGU-AGC-GGCGAGCGAACGGGG-AUC AGCCCAUU-AAGU--------------------------------UAUG----------- ------------------------------------------------------------ -------------------U-------G-----UGUUUUAG------UGG-AACG--CUC UG-GG-------AAGUG------C-GAAC-GUAGAGGGUGAUAUUCCCGUACACGAAAGG ---GCA-CA---------C-------AUAAUG-AUGAC----GAGUAGGGCGAGGCACGU GAAACCUUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCUGUGAGGGGAGU GAAAUAGAUCCUGAAACCGCAUGCAUA-CAA-GCAGU-GGGAGCAC-C----------UU C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G----UGG--------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUCAGUAGCGA---GGUUAA-CCG--------------UAU----- ---------AGG-G-G-A-GCCGUAGAGAAA-UCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------UAGUUGCUGGGUAUA-GACCCGAAACCAG-GCGAUC UAUCCAUGAGCAGGUUGAAGGUUGG-GUAACAC-UAACUGGAGGACCGA--ACCC-ACUG -UCGUUGAAAAGCCAGGGGAUGACUUGUGGAUAGGGGUGAAAGGCUAAUCAAGCCUGG-U GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGGA-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-CAUAGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGU-C-AUCCC-GACUUA-CCAAACCGAUGCAAACUCCGAAUACCUA-UGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ---------C---UA--U-CCGGG-AGA-CAG-ACU--GC-GGGUGCUAACGUCCGU-AG -UCAAGA-GGAAA----ACA--AUCCAGACCGCC-AGCUAAG--GCCCC--AAAAUC--A U-A-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCAUAGACAGCUAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCU--AAAACUA---UGU--------GCC--G AAG-CUGCGGA--UUU---G--A----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUUA----------------------------- ---------------------------------GU-C-A-A-GU-GG--UAGGG----GA ---G-CGUU-CUGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGUG-U--A-UUGA-GA-AGU--AUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACGU-GAGUA-ACG-A--CAA-AACGG-G------------------UGAAAAA----- ----------CCCGUU-CGCC-GAA-AGACC-AAGGGUUCCA-GUCCAACGUUAAUCGGG GCUGGG------------UGAGUCGACCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAU-UGG--U UAA----UAUU-CCA----AUACU-U-CU-G--UGUA-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-AGA-GG-AC--GGAG-A AGGUUA--AG--U-CA-GC-C-UGG--CGU---UGG-----UUGU--CC-AGG-U-GG-- -A------AGG------AU-G------U------A---G----G---U-----A----UG U-A------U---CU-UA-G--G-----C--AAA-U-CCG-GGGUA-CU-----CUAU-A -CU-G--A-GA-U--C--C-G--A-UA-G-CAA--GC-UGUA------------------ ---------CU-UG-----------------------------U--AC-AGC--GAA--G UG-G----CU-GAUAC-CAUG---CUUC-CAGGAAA-A-G-UCUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UU-A-CAC--AG-G-AAUCGUACCCGAAACCGACACAGGUGGUCA-GGU-CGAGUA -G-ACCAAGG-CG-CU-UGAG-AGAACUCU-GCUGAAGGAACUAGGCAAAA-UGGUACCG UAACUUCGGG-AGAAGGUACGC-UG-UU--G-UU-GGUGAUG-GA-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UUC-C-U----- G-----AGC-U-G--A-UGACA-GCCGCAGAAACCAGGCCGCUGCAA-----CUGUUUAU UAAAAACAUAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-AUGCCUGCCCGGUGC-U-GGAAGGUUAAUUGAUGGGGUU-AGC-----GUA A------GCG-AAGCUCUUGAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCAUAAUG AU-G--GCGGC--GCUGUCUCCA-GC-AGA-GGCUCAGUGAAAUCGAAAU-CGCUGUGAA GAUGCAGUGUACCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUGCAGCUUGAC ACUGAACUUUGACCUUACUUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GUU--GG AAC--------------------------------------------------------- ----------------------------------GCUA--GUUCC--AAUGGAGC--CG- UCCU-UGAAAUA-CCACCCUGGUAAU-GUUGAGGUUCUAA-CUCUG--UC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GAC-GAGGA -CCG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCUA-AAGAGUAAC-GGAGG AGUACGAAGGUGCGCUCAGCGUGGUCGGAAAUCACGCGUA-GAGUAU-AAAGGCAAAA-G CGCGCUUAACUG-CGAGACCC-A----CAAGUCGAGCAGGUACGAAAGUAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCUCAUCCUGGGGCUGAAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGAGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUACCG --UGG--G-CGC------------------------------------------------ -----UGGAAAU-UUGAGAGGAU--CUGCUCCUAGUACGAGAGGACCAGAGUGGACGAAC CUC-UGGUGUA-CCGGU-UGUGACGCCAGUCGC-AU--CGCCGGGUAGCUA-U-GUUCGG AAG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UAC-CUCAAGA--- --UAAGAUU---------------------------UC--CCU--------AG-G--A-- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- --------U-UCCU-CUAA---AGAGC---CGUU--C-GAGACUAGGA-CG-UUGAUAGG UUGGA-UGUGGAAG-CAU-A-------------------------GUGA----------- --UAUGU--G--AAGCU-----GACC----A-AUACUAA-UUGCUC-GU--GAGG-CUUG -ACU---- >Agrobacterium_tumefaciens ---AAGAAGU---GAAUUAAGGGCAUUU-GGUGGAUG-CCU-UGGCA-UGC-A--CAGGC GAAGAAGGACGUGAU-ACGCUGCGAAAAGCCGUGGGGAGCUGCGAA-UA-AGCUUU-GAU CCAUGGAUCUCCGAAUGGGGCAACCCACCUUAAAUGCUUGGGAAA-UC------------ ------------------------------------------------------------ --------------------------------UUUCCAAGCAUUGUGAUAAGGUAUCUUA CUUUC--------------------------GAAUACAU-A------------------- ---------------GGG-GUAAGAAGCGA-ACGCAGGGAACUGAAACAUCUAAGUACCU --GCAGGAAAGGACAUCAA-CCGAGACUCCGCAAGU-AGU-GGCGAGCGAACGCGG-ACC AGGCCAGU-GG-CAA------------------------------UG-A----------- ------------------------------------------------------------ -------------------U-------------GAAUAAAG------CGG-AACG--AUU UG-GA-------AAAGU------C-GGCC-AUAGAGGGUGAUAGCCCCUUACGCGUAGAA -C-A-G-UC---------A---------U-UG-----UCCUUGAGUAGGGCGGGACACGU GAAAUCCUGUCUGAACAUGGGGAGACCA--CUCUCCAAGCCUAAGUACUCG-UG-CAUGA CCGAUAGC-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGACGAGGGGAGU GAAAUAGAACCUGAAACCGGAUGCCUA-CAA-ACAGU-CGGAGC---------------- --------------------------------------------------C--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCAAG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAA CGACUUAG-U----GUAACUAGCAA---GCUUAA-GCC--------------GGUA---- ---------GGU-G-U-A-GGCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AUU------------------ ------------------------GAGUUAGUUGCAUUA-GACCCGAAACCGA-GUGAUC UAGCCAUGAGCAGGCUGAAGGUUGG-GUAACAC-CAACUGGAGGGCCGA--ACCC-GUAU -CUGUUGCAAUAGAUUGGGAUGACUUGUGGCUAGGGGUGAAAGGCCAAUCAAACUCGG-A AAUAGCUGGUUCUCCGCGAAAUCUAUUUAGGUAGAGCGUCGAC-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-CCUCGGGGGUAGAGC-ACUGGAUGGG--CU-A UG--G-GGA-C-UCACC-GUCUUA-CUGAUCCUAACCAAACUCCGAAUACCGA-GGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--G-UCGGC-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAAA-GGGCA----ACA--ACCCUGACCUCC-AGCUAAG--GUCCC--CAAGUC--A U-G-GC-U-AAG--UGGGA-----------AAGGAUGUGAGGAUCCCAAAACAACCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAACAGCUCACUGGUCUAAAUA AGGGUC-UUGCGCCGAAAAUGUAACGGGGCUA-A-AGCCA---UGC--------ACC--G AAG-CUGAGGA--UUU---G-------CA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- --------------------------------UG--C-A-A-GU-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------UC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGCG-G-AC-CCGU-GA-GGG--CUGC-U-GGA-GAUAUC-G--GAAGUGCGAAUGU-U GACAU-GAGUA-ACG-A--UAA-AGGGA-G------------------UGAGAGA----- ----------CUCCCU-CGCC-GAA-AGACC-AAGGGUUCCU-GCUUAAAGUUAAUCUGA GCAGGG------------UUAGCCGGCCC-C-UAA----GACG-A-GGCGGAC--ACGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-ACG--U UAA----UAUU-CGU----GGGCC-U-GG-U--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GU-AGU--G-AC--GGAU-C UCGUGU--GU--U-GU-AC-A-ACC-UUAU---UGG-----AUU---GG-UUG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GC-G----GC----GAAG-AG---GUUC-CAGGAAA-U-A-GCUC---C--A-------- ------------------------------------------------------------ ---------CCG--UAUA-GACCGUACCCGAAACCGACACAGGUGGUCA-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAACUAU-GUUGAAGGAACUCGGCAAAU-UGCACGCG UAACUUCGGA-AGAAGCGUGAC-CC-CA-----------UUU-UA-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CUA-U-G----- A-----------------UGGG-GUGGCACAGACCAGGGGGUAGCGA-----CUGUUUAU CAAAAACACAGGGCUCUGC-GAAGUA--GC---A-A------------UACGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAAGGGAGGGGU----------GCA A------------GCUCUGAACUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--GCUGUCUCCA-AC-AUA-GACUCAGUGAAAUUGAAUU-CCCCGUGAA GAUGCGGGGUUCCUGCGGUCAGACGGAAAGA-CCCCGUGCACC-UUUACUAUAGCUUUAC ACUGGCAUUCGCCAAGGCAUGUGUAGGAU-AGGUGGUAG-GC-UU-U-GAA--GCA--GG GAC--------------------------------------------------------- ----------------------------------GCCA--GUUUC--UGUGGAGC--CA- UCCUU-GAAAUA-CCACCCUUAUCUU-CGUGGAUGUCUAA-CCGCG--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUC-CGGGA -CAG-UGUAUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCGA-AAGAGUAAC-GGAGG CGCGCGAUGGUUAGCUCAGACCGGUCGGAAAUCGGUCGUC-GAGUGC-AAUGGCAUAA-G CUAGCCUGACUG-CGAGACUG-A----CAAGUCGAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--UGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUGACCCCCAAGAGUCCAUAUCGACGGGGUUGUUUGGCACCUC GAUGUCGACUCAUCGCAUCCUGGGGCUGGAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGCGGUACGUGAGUUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----AGGAAUA-UUGACAGGAU--CUGUCCCUAGUACGAGAGGACCGGGAUGGACGUAU CUC-UGGUGGA-UCUGU-UGUCCUGCCAAGGGC-AU--AGCAGAGUAGCUA-U-AUACGG AAU-GGAUAACCGCUGAAGGCAUC--U-AAGCGGGAAACC------AAC-CUGAAAA--- --CGAGUGU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CUAU--CAGAGC---CGUG--G-AAGACGACCA-CG-UUGAUAGG ACGGG-UGUGGAAG-CAC-A-------------------------GCAA----------- --UGUGU--G--AAGCU-----UACC----G-UUACUAA-UAGCUC-GA--UCGA-CUUC -UUCGU-- >Anabaena_variabilis --GGUCAAGC---U-AAUAAGGGCUAAU-GGUGGAUA-CCU-AGGCA-CAC-A--GAGGC GAAGAAGGACGUGGU-UACCGACGAAAUACUCCGGGGAGUUGGAAG-CA-AACUA-UGAG CCGGAGAUGUCCGAAUGGGGCAACCCUAA-AU-ACUA----------------------- ---------------CC------------------------------------------- -------------------------------------------------------UGU-U -------------------------------GAAUAUAU-A------------------- ---------------GACAGGAAAGAGCCA-ACCCAGCGAACUGAAACAUCUUAGUAGCU --GGAGGAAGAGAAAUCAA-AAGAGAUUCCCUGAGU-AGU-GGUGAGCGAAAGGGGA-AG AGCCUAAA-CCAGUUG--G------------UU-----------UA--CUGACUGGGG-- -------------------------UAGUGGGACAGCGAU-------------------- -----AUCGAAU-------C--------U---AGAGAUUAG------ACG-AAGC--AGC UA--A-------AUACU------G-CACC-AGAGAAAGUGAAAGUCUUGUAGUCGAAAAU -U-GAA-GG---------A-U----AGUAGC---UGAAUCCCGAGUAGCAUGGGGCACGA GGAAUCCCAUGUGAAUCAGCGAGGACCA--UCUCGUAAGGCUAAAUACUAC-UG-UGUGA CCGAUAGU-GAACC-AGUACCGCGAGGGAAAGGUGAAA-AGAAC-CCCGC-AAGGGGAGU GAAAUAGAACAUGAAACCAUUAGCUUA-CAA-GCAGU-GGGAGUCCGA----------UU A-------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GAUGACCGCGUGCCUGUUGAAGAAUGAGCCGG CGACUUAU-A----GGCACUGGU-A---GGUUAA-GAC--G-----------AGAA---- --------UGUC-G-G-A-GCCAAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAA--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------A------------------- ------------------------UAAUCAGUGUUUAUA-GACCCGAACCCUG-GUGAUC UAACCAUGGCCAGGAUGAAGCUUGGGU-AACAC-CAAGUGGAGGUCCGA--ACCG-ACCG -AUGUUGAAAAAUCGGCGGAUGAGUUGUGGUUAGGGGUGAAAUGCCAAUCGAACCAGG-A GCUAGCUGGUUCUCCCCGAAAUGUGUUGAGGCGCAGCGGUAAU-G--------------- ------------------------------------------------------------ --------------------AUUA-UA-GUCGGGGGGUAAAGC-ACUGUUUCGG--UG-C GG--G-CUG-G-GAGA--CCGGUA-CCAAAUCGAGACAAACUCAGAAUACCCG-AUG-G- A-C--------------------------------------------------------- ------------------------------------------------------------ -------------AC--A-UUGCC-AGU-GAG-ACG--GU-GGGGGAUAAGCUUCAU-CG -UCAAGA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--CAAAUC--A U-C-GC-U-AAG--UGAUA-----------AAGGAGGUGAGAUUGCCUAGACAACUAGGA GGUUUGCCUAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAAUAGCUCACUAGUC-----A AGCGAUCUUGCGCCGAAAAUG-AACGGGGCU--A-AGCGA---UGU--------ACC--G AAG-CUGUGGG--AUU---A--A----CU-A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AACAU----------------------------- ------------------------------------U-A-A-UC-GG--UAGGG----GA ---G-CGUU-CCGUAGU-------------------AG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AAGA AGCAG-U--A-GCGGCAA-GCA--GCUG-U-GGA-CGAGAC-G--GAAGUGAGAAUGU-C GGCUU-GAGUA-GCG-C--AAA-CAUUG-G------------------UGAGAAU----- ----------CCAAUG-CCCC-GAA-ACCCU-AAGGGUUCCA-GAGCCAGGUUCGUCCAC UCUGGG------------UUAGUCGGGAC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-ACA-GGG--U CAA----CAAU-CCC----UGACU-A-UG-G--UAUG-G-G------------------- ----------------------------------------------------------AG CAUU-------------------------------------------------------- ----------------------------------------GC-UAG-GG-AC--GCAUGA AAGAUA--G---C-UA--C---------------------------------G-C-CC-- -U-------G-------A------------------------------------------ -----UUGG--------------------------------------------------- ------------U-----U------UG-G-GAG--GA-GUU------------------- ---------UA-CG--------------------------------AA-CUC--CGA--G UA-G-----U-GA-AG-GAUA---GUGU-CAAGAAA-A-G-CUAG---U-AAUGUG-AU- -G---------------------------------------------------------- -A--AC-A-UAU--CG-U-ACCCGUACCCGAAACCGACACAGGUAGGGA-GGU-UGAGAA -U-ACCAAGG-GG-CG-CGAG-AUAACUCU-CUCUAAGGAACUCGGCAAAA-UGGCCCCG UAACUUCGGA-AGAAGGGGUGC-CCACC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AUGAG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GUGG-GUCGCAGUGAAGAGAUCCAGGCGA-----CUGUUUAC CAAAAACACAGGUCUCCGC-AAACUC--GU---A-A------------GAGGAA-GU-AU GGGGGCUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGGAAGUUGGUC-AGGGC---GAA A----GUUUG-AAGCUGACGACCGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAACG AU-C--UGGAU--GGUGUCUCAG-AG-AGA-GACUCGGCGAAAUAGGAAU-GUCUGUGAA GAUACGGACUGCCUGCACCUGGACAGAAAGA-CCCUAUGAAGC-UUUACUGUAGCCUGGA AUUGUGUCCGGGCUUCGCUUGCGCAGGAU-AGGUGGGAA-GC-GA-U-GAA--GUA--UU CCU--------------------------------------------------------- ----------------------------------UGUG--GGGAA--UAUGGAGC--UA- ACGG-UGAGAUA-CCACUCUGGCGAA-GCUAGGAUUCUAA-CUUAU--UU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AAA-AAGGA -CAG-UUUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCGCAAAGGUUCCCUCAGCACGCUUGGAAACCGUGCGGC-GAGUGU-AAAGGCAUAAAG GGAGCUUGACUG-CAAGACCG-A----CAAGUCGAGCAGGUACGAAAGUAGGCCUU-AGU G-AUCCGACG-------------------------G---------CGCAG--AAU-GGA- -----------------------------AUGGCCGUCGCUCAACGGAUAAAAGUUACUC UAGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAACCUGGGGCGGAAGUACGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCAUAUCCGGUG --CAG--G-CGU------------------------------------------------ -----AAGAGCA-UUGAGAGGAG--CCUUCCUUAGUACGAGAGGACCGGGAAGGACGCAC CGC-UGGUGUA-CCAGU-UAUUGUACCCGCAGU-AG-ACGCUGGGUAGCCA-A-GUGCGG -AGCGGAUAACCGCUGAAAGCAUC--U-AAGUGGGAAGCC------CAC-CUCAAGA--- --UGAGUGC---------------------------UC--UCA--------CU-A--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ACCAA---------------------------- ----------GUAG---GU--AAGGUC---ACGG--G-CAGAACACCC-GU--UUAUAGG CUCUA-AGUGGAAG-UGC-A-------------------------GUAA----------- --UGUAU--G--AAGCU-----GAGG----A-GUACUAA-CAGACC-GA---GGG-CUUG -ACCUC-- >Azoarcus_sp. --GAUCAAGC---GA-CUAAGUGCAUGU-GGUGGAUG-CCU-UGGCG-AUC-A--CAGGC GAUGAAGGACGUGCA-AGCCUGCGAAAAGCGGGGGGGAGCUGGCAAUGG-AGCUUU-GAU CCCCCGAUAUCCGAAUGGGGAAACCCGGCCCGCAA------------------------- ------------------------------------------------------------ ------------------------------------GGGUCA-------------UCC-C GUACU--------------------------GAAUCCAU-A------------------- ---------------GGUACGUGGAAGCGA-ACGCGGCGAACUGAAACAUCUAAGUAGCC --GUAGGAAAAGAAAUCAA-CCGAGAUUCCCCAAGU-AGU-GGCGAGCGAACGGGG-AAG AGCCUGC--ACGACU-----------------------------AAACC----------- ------------------------------------------------------------ -------------------A-------U-----CAGCUUAG------CAA-AACG--GUC UG-GA-------AAGUC------C-GACG-AUACAGGGUGAUAGUCCCGUAUGCGAAAAG -C-CGG-UG---------G-C----GGGUCUGAGCGUGCGACAAGUAGGGCGGGACACGU GUAAUCCUGUCUGAAGAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCG-UG-AUCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAUCCUGAAACCGCAUGCAUA-CAA-ACAGU-GGGAGCC-------------UG GA------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-G----UUCAGUGGCGA---GCUUAA-CCG--------------AAU----- ---------AGG-G-G-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AUA--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------ACA------------------ ------------------------UAGUCGCUGGGCGUA-GACCCGAAACCGG-AUGAUC UAUCCAUGGCCAGGAUGAAGGUGCG-GUAACAC-GCACUGGAGGUCCGA--ACCC-ACUA -GUGUUGAAAAACUAGGGGAUGAGCUGUGGAUAGGGGUGAAAGGCUAAACAAAUCCGG-A AAUAGCUGGUUCUCCCCGAAAACUAUUUAGGUAGUGCGUCGUA-C--------------- ------------------------------------------------------------ --------------------GGAC-AC-UUGCGGGGGUAGAGC-ACUGUAAUCG--UUGG GG--G-GGU-C-ACUGC-GAUCUA-CCCCGCGAUAGCAAACUCCGAAUACCGC-AAA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------AU--AU----ACGGC-AGA-CAG-ACA--UC-GGGUGCUAACGUCCGG-UG -UCAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--AAAUGC--A U-G-GC-U-AAG--UGGCA-----------AACGAGGUGGGAAGGCAUAGACAGCUAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCUC-A-AGCCA---UGA--------ACC--G AAG-CUGCGGA--UGU---G--U----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UU-U----------------------------- --------------------------------G-A-C-A-C-GU-GG--UAGGG----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGUG-U--C-UCGU-AA-GGG--AUGC-U-GGA-GGUAUC-G--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--UAA-AGGGU-G------------------UGAAAAG----- ----------CACCCU-CGCC-GAA-AGCCC-AAGGUUUCCU-GCGCAACGUUCAUCGGC GCAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCAGAA--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U CAA----UAUU-CCU----GUACC-G-GU-U--CUAG-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GGAG-A AGGUUA--GG--C-CG-GC-C-GGG--UGU---UGGA----CGU---CC-CGG-U-UU-- -A------AGC------GU-G------U------A---G----G---C-----G----UG C-U------C---UC-UA-G--G-----C--AAA-U-CCG-GAGAG-CU------GA--G -CU-G--A-GG-C--G--U-G--A-UG-A-CGA--GC-GAA------------------- ---------CU-UG--------------------------------UU-CGC--GAA--G UG-G----UU-GAUAC-CCUG---CUUC-CAGGAAA-A-G-CCUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UC-U-AGA--AU-C-GACCGUACCGCAAACCGACACAGGUGGGCA-GGU-UGAAAA -U-ACCAAGG-CG-CU-UGAG-AGAACUCA-GGAGAAGGAACUCGGCAAAU-UGAUACCG UAACUUCGGG-AGAAGGUAUGC-CC-CA-UU-AG-CUUGUAG-GA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G U--AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AUC-C-G----- A-----AGG-G-C--G-AAGGG-GCCGCAGAGAAUCGGUGGCUGCGA-----CUGUUUAU UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGUGAUGGGGU----------GCA A------------GCUCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCU-CC-UGA-GACUCAGCGAAGUUGAAAU-GUUUGUGAA GAUGCAAUCUCCCCGCGGCUAGACGGAAAGA-CCCCAUGAACC-UUUACUGUAGCUUUGC AUUGGACUUUGACGGGACUUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GCC--AG GAC--------------------------------------------------------- ----------------------------------GCUA--GUUCU--GGUGGAGC--CG- UCCU-UGAAAUA-CCACCCUGGUGUC-GUUGAGGUUCUAA-CCCAG--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-GGGAA -CAG-UGCAUGGUAGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAAGGUAAC-GGAGG AGUUCGAAGGUCUCCUAGGUACGGUCGGACAUCGUACUGA-UAGUGC-AAUGGCAAAA-G GAGGCUUGACUG-CGAGACCG-A----CAAGUCGAGCAGGUGCGAAAGCAGGACAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUUCCGCCCAAGAGUUCACAUCGACGGCGGAGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGUAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGC------------------------------------------------ -----UGGAAGU-UUGAGGGGAC--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGCAC CUC-UGGUGUA-CCGGU-UGUGACGCCAGUCGC-AU--CGCCGGGUAGCUA-A-GUGCGG AAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------CGC-CUCAAGA--- --UGAGACU---------------------------UC--CCU--------GG-G--G-- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUCGA---------------------------- --------U-CCCC-CUGA---AGGGU---CGUG--G-AAGACCACCA-CG-UUGAUAGG UCGGG-UGUGGAAG-CGC-A-------------------------GUAA----------- --UGCGU--U--AAGCU-----AACC----G-AUACUAA-UUGCCC-GU--GAGG-CUUG -AUCCU-- >Bacillus_anthracis --------------------GGGCGCAC-GGUGGAUG-CCU-UGACA-CUA-G--GAGUC GAUGAAGGACGGGAC-UAACGCCGAUAUGCUUCGGGGAGCUGUAAG-UA-AGCUU-UGAU CCGAAGAUUUCCGAAUGGGGAAACCCACCAUA-CGUA----------------------- ---------------AU------------------------------------------- ---------------------------------GGUAUGGUA-------------UCC-U UAUCU--------------------------GAAUACAU-A------------------- --------------GGGUAAGGAAGACAGA--CCCAGGGAACUGAAACAUCUAAGUACCU --GGAGGAAGAGAAAGCAA-AUGCGAUUUCCUGAGU-AGC-GGCGAGCGAAACGGAACAU AGCCCAAA-CCAAGAG--GC-----------UU-----------G---CCUCUUGGGG-- -------------------------UUGUAGGACAUUCUA-------------------- ----UACGGAGUUACAAAGG--------A---AUGAGGUAG------ACG-AAGCG-ACC UG-GA-------AAGGU------C-CGUC-GUAGAGGGUAACAACCCCGUAGUCGAAACU -U-CGU-UC---------UCU----CUUGAA---UGUAUCCUGAGUACGGCGGAACACGU GAAAUUCCGUCGGAAUCUGGGAGGACCA--UCUCCCAAGGCUAAAUACUCC-CU-AGUGA UCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GAAGGGGAGU GAAAGAGAUCCUGAAACCGUGUGCCUA-CAA-AUAGU-CAGAGCCCGU----------UA AC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUGGCGUGCCUUUUGUAGAAUGAACCGG CGAGUUAC-G----AUCCCGUGCGA---GGUUAA-GCU-------------GAAGA---- ---------GGC-G-G-A-GCCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------UAGUACGUGGUCGUA-GACCCGAAACCAG-GUGAUC UACCCAUGUCCAGGGUGAAGUUCAG-GUAACAC-UGAAUGGAGGCCCGA--ACCC-ACGC -AUGUUGAAAAGUGCGGGGAUGAGGUGUGGGUAGCGGAGAAAUUCCAAUCGAACCUGG-A GAUAGCUGGUUCUCCCCGAAAUAGCUUUAGGGCUAGCCUUAAGUG--------------- ------------------------------------------------------------ --------------------UAAG-AG-UCUUGGAGGUAGAGC-ACUGAUUGGA--CU-A GG--G-GUC-C-UCAUC-GGAUUA-CCGAAUUCAGUCAAACUCCGAAUGCCAAUGA--C- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UC--C-UUAGG-AGU-CAG-ACU--GC-GAGUGAUAAGAUCCGU-AG -UCAAAA-GGGAA----ACA--GCCCAGACCGCC-AGCUAAG--GUCCC--AAAGUG--U G-U-AU-U-AAG--UGGAA-----------AAGGAUGUGGAGUUGCUUAGACAACUAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAGAGUGCGUAAUAGCUCACUAGUC-----G AGUGACUCUGCGCCGAAAAUGUACCGGGGCU--A-AAUAC---ACC--------ACC--G AAG-CUGCGGA--UUG---A--U----AC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAU----------------------------- -------------------------------GGUA-U-C-A-GU-GG--UAGGG----GA ---G-CGUU-CUAAG-G-------------------AC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGUCA-G--A-CCGG-AA-GGA--CUGG-U-GGA-GUGCUU-A--GAAGUGAGAAUGC-C GGUAU-GAGUA-GCG-A---AA-GACGG-G------------------UGAGAAU----- ----------CCCGUC-CACC-GAA-UGCCU-AAGGUUUCCU-GAGGAAGGCUCGUCCGC UCAGGG------------UUAGUCAGGAC-C-UAA----GCCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGAC-AAC-AGG--U UGA----UAUU-CCU----GUACC-A-CC-UC-UUUA-U-C------------------- ----------------------------------------------------G-UUUGAG CAA--------------------------------------------------------- ----------------------------------------UG-GAG-GG-CC--GCAG-A AGGAUA--GA--A-GAAGC-G-UGC--GAU---UGGU----UGU---GC-ACG-U-CC-- -A------AGC------AG-U------U------A---G----G---C----------UG A-U------A---AG-UA-G--G-----C--AAA-U-CCG-CUUAU-CG----UGAAG-G -CU-G--A-GC-U--G--U-G--A-UG-G-GGA-AGC-UCC------------------- ---------UU-AU--------------------------------GG-AGC--GAA--G UC-U----UU-GAUUC-CCCG---CUGC-CAAGAAA-A-G-CUUC---U--A-GCG---- -A---------------------------------------------------------- -G--AU-A-AAA--GG-U-GCCUGUACCGCAAACCGACACAGGUAGGCG-AGG-AGAGAA -U-CCUAAGG-UG-UG-CGAG-AGAACUCU-GGUUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-UU-UC--U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U AA-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GGAAA-GCCGCAGUGAAUAGGCCCAAGCGA-----CUGUUUAG CAAAAACACAGCUCUCUGC-GAAGCC--GU---A-A------------GGCGAA-GU-AU AGGGGGUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGGAGAGGGGUU-AGC-----GUA A------GCG-AAGCUCUGAACUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGUGUAACG AU-U--UGGGC--ACUGUCUCAA-CC-AGA-GACUCGGUGAAAUUAUAGU-ACCUGUGAA GAUGCAGGUUACCCGCGACAGGACGGAAAGA-CCCCGUGGAGC-UUUACUGUAGCCUGAU AUUGAAUUUUGGUACAGUUUGUACAGGAU-AGGCGGGAG-CCUU--U-GAA--ACC--GG AGC--------------------------------------------------------- ----------------------------------GCUA--GCUUC--GGUGGAGG--CG- CUGG-UGGGAUA-CCGCCCUGACUGU-AUUGAAAUUCUAA-CCUAC--GG--------GU C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GA-C-CCG-GGAGA -CAG-UGUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGUGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGAAUGGUUGGAAAUCAUUCGUA-GAGUGC-AAAGGCAUAA-G GGAGCUUGACUG-CGAGAACU-A----CAAGUCGAGCAGGGACGAAAGUCGGGCUU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGCUACCC CGGGGA-UAACAGGCUUAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --UGG--G-CGU------------------------------------------------ -----AGGAAAU-UUGAGAGGAG--CUGUCCUUAGUACGAGAGGACCGGGAUGGACGCAC CGC-UGGUGUA-CCAGU-UGUUCUGCCAAGGGC-AU--AGCUGGGUAGCUA-U-GUGCGG AAG-GGAUAAGUGCUGAAAGCAUC--U-AAGCAUGAAGCC------CCC-CUCAAGA--- --UGAGAUU---------------------------UC--CCA--------UA-G--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ----------GCUA---GU--AAGAUC---CCUG--A-AAGAUGAUCA-GG-UUGAUAGG UUCGA-GGUGGAAG-CAU-G-------------------------GUGA----------- --CAUGU--G--GAGCU-----GACG----A-AUACUAA-UAGAUC-GA---GGA-CUUA -ACCAU-- >Bacteroides_thetaiotaomicron ------------------AAGGGCGCAU-GGCGGAUG-CCU-UGGCU-CUC-G--GAGGC GAUGAAGGACGUGAU-AAGCUGCGAUAAGCUCUGGGUAGGUGCAAA-UA-ACCUUU-GAU CCAGAGAUUUCCGAAUGGGACAACCCGGCAUUCUGAA-------------G--------- ------------------------------------------------------------ -------------G---------------------AAUGUCA-------------UCC-A UC-------------------------------UU------------------------- ------------------UGAUGGAAGCUA-ACGCAGGGAACUGAAACAUCUUAGUACCU --GUAGGAAAAGAAAAUAA-UAAUGAUUCCCCUAGU-AGU-GGCGAGCGAACGGGG-AAU AGCCCAAA-CC-ACCC-AUGUUA---------------------CGGCAUGUGUGGGG-- -------------------------UUGUAGGACCACGAUGUCGCA--------AGACA- --UUUG------------AU-------G-----------AG------UAG-AAUC--CUC UG-GA-------AAGUU------G-AACC-AUAGACGGUGAUAGUCCGGUAUACGAAGUC ----AA------------AUU----AAGCGUAGUGGUAUCCUGAGUAGCGCGGGACACGA GAAAUCUUGCGUGAAUCUGCCGGGACCA--UCCGGUAAGGCUAAAUACUCC-CG-AGAGA CCGAUAGC-GAACC-AGUACUGUGAAGGAAAGGUGAAA-AGCAC-UUCGAAUAGAAGAGU GAAAUAGUCCCUGAAACCGUGCGCCUA-CAA-GCGGU-CGGAGCU-------------GC UU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AA--GC---AGUGACGGCGUGCCUUUUGCAUAAUGAACCUA CGAGUUAC-U----UUUUCCGGCAA---GGUUAA-GCA--U-C---------UUGA---- -------GAUGU-G-C-A-GCCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAC--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UC------------------ ------------------------GAGUCGGAAGGAGUA-GACGCGAAACCAA-GUGAUC UACCCUUGGUCAGGUUGAAGGUUAG-GUAACAC-UAACUGGAGGACCGA--ACCG-AUAA -GCGUUGAAAAGCUUCCGGAUGAACUGAGGGUGGGGGUGAAAGGCUAAUCAAACUUGG-A GAUAGCUCGUACUCCCCGAAAUGCAUUUAGGUGCAGCCUUGUG-A--------------- ------------------------------------------------------------ --------------------GUUA-CU-AAUGUGAGGUAGAGCGACUGAUAAGA--UG-C GA--G-GGC-U-UCAC--CGCCUA-UCAAGUCUUGAUAAACUCCGAAUGCGCA-UU--A- GUU--------------------------------------------------------- ------------------------------------------------------------ ---------CU--AU--C-ACAGG-AGU-GAG-GGC--AU-GGGUGCUAAGGUCCAU-GU -CCUAAA-GGAGA----AGA--AUCCAGACCAUC-AGCUAAG--GUCCC--CAAAUA--A A-C-AC-U-AAG--UUGAA-CU--------AACGAAGUCAGAUUGCUAAGACAGCUAGGA UGUUGGCUUGG-AAGCAGCCAUUCAUUUAAAGAGUGCGUAACAGCUCACUAGUC-----G AGGAGUUUGGCGUGGAUAAUA-AUCGGGCAUU-A-AGUGU---UUU--------ACC--G AAG-CUAUGGG--AUC---A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ------------------------------------U-G-A-UC-GG--UAGGG----GA ---G-CAUU-CCACUCU-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UCGA AGGUG-A--A-GCGU-GA-GCU--UUGC-U-GGA-GCGUGU-G--GAAAAGCAAAUGU-A GGUAU-AAGUA-ACG-A--UAA-AGGGG-G------------------UGAGAAA----- ----------CCCCCU-CGCC-GAA-AGACU-AAGGUUUCCU-GAUCAACGCUAAUCGGA UCAGGG------------UUAGUCGGGUC-C-UAA----GGCC-C-AGCCGAA--CGGUG ---------------------------A-G-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--U-GGCAGAAC-AGG--U UAA----UAUU-CCU----GUACU-A-CC-U--UAAG-G-A------------------- -----------------------------------------------------------G UGA--------------------------------------------------------- ----------------------------------------CG-UGG-AG-AC--GGAG-C AGUGAC--AG--C-GCCGC-G-GAC--UGA---CGGA----AUA---GU-CCG-U-UG-- -A------AGG------GU-G------U-A--GAU---G----U---U-----G----AU C-A------U---CC-CA-G--G-----C--AAA-U-CCG-GGAUG-AG------A---G -UC-G--A--A-C--C--U-G--A-UA-G--UA--UG-GAGC-GU-UC------------ ---------UU-CG-----------------------GA-AC-A--AU-CCA-AUA---- GU-GC---GU-GUAAG-CAUA---CUCC-CAAGAAA-A-U-CCGC---U--A-AAC-UU- AA---------------------------------------------------------- -U--CC-U-UGA--GG-U-ACCCGUACCGCAAACGGACACACGUAGUCG-GGU-UGAAUA -U-ACUAAGG-CG-CU-UGAG-UGAUUCAC-GGUUAAGGAACUAGGCAAAU-UGACCCUG UAACUUCGGG-AUAAAGGGUCC-CA-AC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GUUG-GGCGCAGAGAAUAGGUCCAGGCAA-----CUGUUUAA CAAAAACACAGGGCUGUGC-CAAAUU--GA---A-A------------GAUUAC-GU-AU ACAGCCUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGAUGUC-AUC-----GCA A------GAG-AAGCAUUGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGUGUAAUG AU-C--UGGAC--ACUGUCUCAA-CC-GUG-AGCUCAGUGAAAUUGUAGU-AUCGGUGAA GAUGCCGAUUACCCGCGAUGGGACGAAAAGA-CCCCGUGAACC-UUUACUAUAGCUUAAC AUUGAAUUUGGGUAAUUGAUGUGUAGGAU-AGGCCGGAG-AC-UU-U-GAA--GCA--GG UAC--------------------------------------------------------- ----------------------------------GCCA--GUAUU--UGUGGAGU--CG- CUGU-UGAAAUA-CGGCCCUUUGAUU-AUUUGAGUUCUAA-CUC-G--U----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AGUU- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GC-GAGGA -CAC-UGUUUGGUGGGUAGUUUGACUGGGGUGGU-CGCCUCCAA-AAUAGUAAC-GGAGG CUUCUAAAGGUGCCCUCAGGACGAUUGGUAACCGUCCGUA-GAGUGU-AAUGGCAUAA-G GGCGCUUGACUG-GGAGACUA-A----CAAGUCGAUCAGGUAGGAAACUAGAGCAU-AGU G-AUCCGGUG-------------------------U---------UUCCG--UAU-GGA- -----------------------------AGGGACAUCGCUCAAAGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUCCCUCCCAAGAGCUCAUAUCGACGGAGGGGUUUGGCACCUC GAUGUCGGCUCGUCACAUCCUGGGGCUGGAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGUGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCUCUAUCUAUCG --UGG--G-CGU------------------------------------------------ -----AUGAAAU-UUGCGUGGCU--CUGACACUAGUACGAGAGGACCGUGUUGGACUGAC CGC-UGGUUUA-CCAGU-UGUGCCGCCAGGUGC-AU--UGCUGGGUAUCUA-A-GUCGGG AAU-GGAUAAGUGCUGAAAGCAUU--CUAAGUACGAAGCC-----------ACAAGA--- --UUAGA-U---------------------------UC--UU---------GG-G--U-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CGUU--A-AAGACGAUGA-CG-UUGAUAGG AUGCA-GGUGUAAA-GGU-G-------------------------GUAA----------- --CAUCA--A--AGCC------GAGC----A-UUACUAA-UUGCCC-GU--UCA--CUUU -------- >Bartonella_henselae ---AUCAAGU---GUCUUAAGGGCAUUU-GGUGGAUG-CCU-UGGCA-UGC-A--CAGGC GAUGAAGGACGUGAU-ACGCUGCGAUAAGCUACGGGGAGGUGCGAA-UA-CCCUUU-GAU CCGUAGAUCUCCGAAUGGGGCAACCCACCUUUGAUGGCUAGAAAAAUUAAGCUGUUU--- ------------------------------------------------------------ ---------------UUUUAAGACAGUUUAAUUUUCUAGUCGUCAGAUAAAGGUAUCU-A CACCU--------------------------GAAUAAAA-U---------------A--- ---------------GGGUGUAAGAAGCAA-ACGCAGGGAACUGAAACAUCUAAGUACCU --GUAGGAAAGGACAUCAA-ACGAGACUCCGUUAGU-AGU-GGCGAGCGAAAGCGG-ACC AGGCCAGU-GG-CUU------------------------------GA-A----------- ------------------------------------------------------------ -------------------G-------C-----AAGAAAAG------UAG-AAUC--GAC UG-GA-------AAGUC------G-AACC-AAAGAGGGUGAUAGUCCCGUAUACGUAACU -C-U-U-CU---------U---------UAAG-----UCCUAGAGUAGGGCGGGACACGU GAAAUCCUGUCUGAAUAUGGGUCGACCA--CGAUCCAAGCCUAAGUACUCG-UG-CAUGA CCGAUAGC-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-CCCGACAAGGGGAGU GAAAAAGUACCUGAAACCGAAUGCCUA-CAA-ACAGU-CGGAGCCCAA----------GA U-----------------------------------------------------UU---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUUCUG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAG-U----CUAACGAGCAA---GCUUAA-GCC--------------GGUA---- ---------GGU-G-U-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAC--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------CAGUUCGUUGGAUUA-GACCCGAAACCGA-GUGAUC UAGCCAUGAGCAGGCUGAAGGUAAG-GUAACAC-UUACUGAAGGGCCGA--ACCC-GUAU -CUGUUGCAAUAGAUUGGGAUGACUUGUGGCUAGGGGUGAAAGGCCAAUCAAACUCGG-A AAUAGCUGGUUCUCCGCGAAAUCUAUUUAGGUAGAGCGUUAGU-C--------------- ------------------------------------------------------------ --------------------GAAU-UC-UCCAGGGGGUAGAGC-ACUGGAUGGG--CU-A GG--G-GUC-C-UCACC-GGAUUA-CCAAACCUAACCAAACUCCGAAUACCUG-GAA-G- A-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--A-CUAGC-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGGAGA-GGGAA----ACA--ACCCUGACCACC-AUCUAAG--GUCCC--CAAGUU--A U-G-GC-U-AAG--UGGGA-----------AAGGAUGUGAGGAUCCCAAAACAACCAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAGAAAGCGUAACAGCUCACUGGUCUAAAUA AGGGUCCCUGCGCCGAAAAUGUAACGGGGCUA-A-AGCCA---UAC--------ACC--G AAG-CUGUGGA--UUU---A--C----UC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAA----------------------------- -------------------------------GGAG-U-A-A-GU-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGGA-G-AC-UCGU-GA-GAG--CUCC-U-GGA-GGUAUC-G--GAAGUGAGAAUGC-U GACAU-GAGUA-ACG-A--UAA-AGGGA-G------------------UGAGAGA----- ----------CUCCCU-CGCC-GAA-AGUCC-AAGGGUUCCU-GCUUAAAGUUAAUCUGA GCAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-ACG--U UAA----UAUU-CGU----GGACC-U-GU-G--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GU-AGU--G-AC--GGAU-U GCGUGU--AU--U-GU-AA-G-GUC-UUAU---UGG-----AUU---GA-UCU------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GC-A----GU----GAAG-CA---GUUC-CAGGAAA-U-A-GCUC---C--C-------- ------------------------------------------------------------ --------ACAU--AG-A-GACCGUACCCCAAACCGACACAGGUGGACU-GGU-AGAGAA -U-ACUAAGG-CG-CU-UGAG-AGAACUAC-GUUGAAGGAACUCGGCAAAU-UGCACGCG UAACUUCGGA-AGAAGCGUGAC-CC-UU-----------UAG-CG-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CCG-U-U----- A-----------------GAGG-GUGGCACAGACCAGGGGGUAGCGA-----CUGUUUAC CAAAAACACAGGGCUCUGC-GAAGUC--GC---A-A------------GACGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGAUGU----------GCA A------------GCAUUGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--GCUGUCUCCA-AC-GUA-GACUCAGUGAAAUUGAAUU-CCCCGUGAA GAUGCGGGGUUCCCGCGGUUAGACGGAAAGA-CCCCGUGCACC-UUUACUAUAACUUUAC ACUGGCAUUUGUGUCUGUAUGUGUAGGAU-AGGUGGUAG-AC-UU-C-GAA--GCA--GG GGC--------------------------------------------------------- ----------------------------------GCCA--GCCCU--UGUGGAGU--CA- UCCU-UGAAAUA-CCACCCUUACCGA-UAUGGAUGUCUAA-CCGCA--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUU-CGGGA -CCG-UGUAUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGAGUAAC-GGAGG CGCGCGAUGGUAGGCUCAGAACGGUCGGAAAUCGUUUGUU-GAGUGC-AAUGGCAUAA-G CCUGCCUGACUG-UGAGACUG-A----CAAGUCGAGCAGAGUCGAAAGACGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--UGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUGACCCCCAAGAGUCCAUAUCGACGGGGUUGUUUGGCACCUC GAUGUCGACUCAUCGCAUCCUGGGGCUGGAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGCGGUACGUGAGUUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----UGGAAUA-UUGACAGGAC--CUGUCCCUAGUACGAGAGGACCGGGAUGGACGUAU CUC-UGGUGGA-CCUGU-UGUGGCGCCAGCCGC-AU--AGCAGGGUAGCUA-U-AUACGG ACG-AGAUAACCGCUGAAGGCAUC--U-AAGCGGGAAACU------CAC-CUGAAAA--- --CAAGUAU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------C--U--GAGAAC---CGUG--G-UAGACUACCA-CG-UUGAUAGG UCAGG-UGUGGAAG-UGU-G-------------------------GUAA----------- --CACAU--G--AAGCU-----UACU----G-AUACUAA-UCGUUC-AA--UCGA-CUUG -AUCGU-- >Bifidobacterium_longum ----GUGUGUUGCU-UGCAAGGGCGUAU-GGUGGAUG-CCU-UGGCA-GAC-A--GGACC GAUGAAGGACGUUUG-AGGCUGCGAUAUGCCUCGGGGAGCCGCCAACAG-GGCUUU-GAU CCGAGGAUUUCCGAAUGGGGGAACCCACCG-----AC----------------CGUC--- ---------------AU----------GGG------------------------------ ---------------------------------UC---GGUA-------------CCG-G CUU--------------------------------------------------------- ------------------CGGCCGGGGGGU-ACGCAGGGAAGUGAAACAUCUCAGUACCU --GCAGGAAAGGA-----------UAUUCCGUGAGU-AGU-GGCGAGCGAAAGCGGAUGA UGGCCAAA-CCUUGCGCGUGUGA-UACCCG-UCGGGGG------UUGCGCGCGGGGUG-- -------------------------UUGCGGGAUCGCGU-GCGCCGGCUCCGACGGGCC- --GGCCGGCAGUUGCAGAAAAC-----CA---UG-UGUCAG------GGG-AACC--GGG UU-GA-------AUACC------G-GGCC-GCAGAGGGUGAGGGCCCCGUACCUGAACGC -G-CAU-GG---------UCU-----GCCGAUCGCGUCUCCCAAGUAGCACGGGUCCCGU GGAACCCCGUGCGAAUCCGCCCAGACCG--UUGGGUAAGCCUGAAUAUUCC-UG-UCUGA CCGAUAGC-GAACG-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-CCCGG-GAGGGGAGU GAAACAGUCUCUGAAACCGUGCGCCUA-CAA-UCCGU-CGGAGCCCUU----------UU GU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------G-G------------GGUGACGGCGUGCCUAUCGAAAAAUGAGUCUG CGAGUCAGUG----GCAUGUGGCGA---GCAUAA-CCC--------------GUGU---- ---------GGG-G-U-A-UGCGUAGCGAAG-GCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAA--------------- -------------------------------------------A-GG-CG---------- ---------------------------------------UUU------------------ ------------------------GAGUCGCGUGUCCUG-GACCCGAAGCGGG-AUGAUC UAGCCCUGAGCAGGUUGAAGCGCGG-GUAAGAC-CGCGUGGAGGACCGA--ACCC-ACCU -GGGUUGAAAACCGGGGGGAUGACUUGGGGCUAGGGGUGAAAGGCCAAUCAAAUUCCG-U GAUAGCUGGUUCUCUCCGAAAUGCAUUUGGGUGCAGCGUCGGG-U--------------- ------------------------------------------------------------ -------------------CAUUA-CG-UCCCGGGGGUAGAGCUACUGGAUGCU--UG-C GG--G-CCC-G--UAU--CGGGUA-CCAACAGCAACCAAACUCCGAAUACCGGUGA--C- GCG--------------------------------------------------------- ------------------------------------------------------------ ----------U--AU--C-CCGGC-AGU-GAG-UCG--GC-GGGGGAUAAGCUUCGU-CG -UCGAAA-GGGAA----ACA--GCCCAGACCGUC-GUCUAAG--GUCCC--GAAGCG--U G-U-GC-U-AAG--UGGGA-----------AAGGAUGUGGAGUCGCAUAGACAGCCAGGA GGUUGGCUCAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAACAGCUCACUGGUC-----U AGUGGUUCCGCGCCGACAAUGUAGCGGGGCUC-A-AGCAC---ACC--------ACC--G AAG-ACGCGGC--AGU---A--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUU------------------------------ ----------------------------------G-U-A-C-UG-GG--UAGGA----GA ---G-CGUC-CCAU-GA-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGCGG-C--C-GUGU-GA-ACGC-GCCG-U-GGA-CUUCAU-G--GGAGUGAGAAUGC-A GACAU-GAGUA-GCG-A---GA-GACGG-G------------------UGAAGAU----- ----------CCCGUC-CGCU-GGA-UGACC-AAGGGUUCCA-GGGCCACGUUCAUCGUC CCUGGG------------UGAGUCGGGUC-C-UAA----GGCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA-AU-GGAUGAAC-GGG--U CGA----UAUU-CCC----GUACC-G-GC-U--UUCA-G-C----C----G--CCAA-AA CCGAGGCUUGGAGUACUAACCUCCGGGU--CCGGGCUU-ACUG---CUCC---------U UCG-----GGGG-C-GGGAU--GCCCUG--GCCUGUUGGGACCG-AUCCUUGUAGUAGGU -----CAGC-G----------------------------CAG-GAG-UG-AC--GCAG-A AGGGUA--GC--C-GG-CC-G-CGG--AGG---UGGU----CUU---CC-GUG-G-UC-- -A------AGC------AC-G------C------A---G----G---G----------CG U-G------G---GA-CA-G--G-----C--AAA-U-CCG-UCCCG-CA----U-GGG-U -CC-G--A-GG-U--G--C-G--A-UG-A-UGG--GG-GCC------------------- ---------UU-AU--------------------------------GG-CCC-GAUA--U CC-G----GU-GAUCC-C-GG---CUGC-CGAGAAA-A-G-CUUC---G--GCGUC--A- G----------------------------------------------------------- -G--CU-C-GAA--GC-C-GCCCGUACCCCAAACCGACACUGGUGGUCA-GGU-AGAGAA -U-ACCAAAG-CG-AU-CGAG-CGAAUCCU-GGUCAAGGAACUCGGCAAAU-CACUCCCG UUCCUUCGGU-UUAAGGGAGAC-CC-CC--G-AU-GGUGAAC-CG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UC-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCG-G-G----- G-----AGC-U-U--U-UGGGG-GUGGCACAGACCAGGGGGUAGCGA-----CUGUUUAC CAAAAACACAGGUGCAUGC-GAAGGC--GC---A-A------------GCCGCU-GU-AU AUGCACUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGAGGAUCCGUC-AGC-C---UUC G----G-GUG-AAGCGGUGAAUUCAAGCCCCG-G-UAAACGG-CGGUGGUAACUAUAACC AUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--ACUGUCUCGA-CC-AGG-AGCUCGGCGAAAUUGCAGU-ACGAGUAAA GAUGCUCGUUAAGCGCAGAAGGACGAAAAGA-CCCCG-GGACC-UUUACUAUACCUUGGU AUUGGCAUUCGGUGUGGAUUGUGUAGCAU-AGGCGGGAG-GC-CG-A-GAG--GCG--CG GUC--------------------------------------------------------- ----------------------------------GCCA--GAUCG--CGCGGAGC--CGU AAGG-UGAAAUA-CCGCUCUGUUCGC-AUUGGAUGUCUAA-CCUCG--AA--------CA G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-CAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CU-G-UUC-AGGGA -CAG-UGCCUGGCGGGUAGUUUAACUGGGGCGGU-UGCCUCCCA-AAGAGUAAC-GGAGG CGCCCAAAGGUCCGCUCAGCCCGGUUGGCAAUCGGGUGGC-GAGUGC-AAGUGCACAA-G CGGGCUUGACUG-CGAGGACG-A----CGGUCCGAGCAGGGACGAAAGUCGGGACU-AGU G-AUCCGGUG-------------------------C---------CGGUG--UAC-GGA- -----------------------------CGCGGCAUCGCUCAACGGAUAAAAGGUACCC CGGGGA-UAACAGGCUGAUCAUUCCCAAGAGUCCAUAUCGACGGGAUGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUUGGUCUCUAUCCUCUG --CGC--U-CGU------------------------------------------------ -----UGGAAUG-CUGAGGAGGC--CUGCCCAUAGUACGAGAGGACCUGGGUGGACGAAC CUC-UGGUAUG-CCGGU-UGUCACGCCAGUGGC-AC--GGCCGGUUGGCUA-C-GUUCGG AAG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UGCUCCAAGAUAGC AUUCCGUGG---------------------------AACCUUC--------GA-G----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------UUCC--UGU---AGUCC---CCAU--G-CAGAACACGU-GG-UCGAUAGG CCGGA-CGUGGAAG-CCC-C-------------------------GCGA----------- --GGGGUG-G--AGCCG-----ACCG----G--UACUAA-CGGACG-AAA-GGCA-ACAC -UAA---- >Blochmannia_floridanus --AGUUAAGU---GAUGUAAGCGUAUAC-GGUGGAUG-CCU-UGGCA-GUC-A--AAGGC GAUGAAGGACGUGCU-AAUCUGCGAAAAGUAUCGGUGAGCUGAUUUGAA-GCGUUAUUAA CCGGUGAUGUCCGAAUGGGGAAACCUAGUGCAAUUUAAA--------------UU----- ---------------GU------------------------------------------- -----------------------------------GC-AUUA-------------UUA-U UUAGU--------------------------GAAUUUAU-A------------------- ---------------GCUAA-AUGAAGCAA-ACCAGAGGAACUGAAACAUCUUAGUACUC --UGAGGAAAAGAAAUCAA-UUGAGAUUCUCGUAGU-AGU-GGCGAGCGAACCGGG-AUA AGCCCA-G-UAGCAAA-AUAUUA---------------------UAAUU----------- ------------------------------------------------------------ -------------------A-------G-----UAUAUUAA------GAG-AAUA--AUU UG-GA-------AAAAU------U-AGCA-AUAUAGGGUGAUAGCCCCGUAUCUGAAAAU -A-UAU-UA---------G-------UUUGUA-AGCUC-GAAGAGUAGGACGGGACACGU GAUAUCUUGUCUGAACAUAGGGGGACCA--UCCUCUAAGGCUAAAUACUCU-UG-ACUGA CCGAUAGU-GAACU-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGGUUAGGGGAGU GAAAUAGAACCUGAAACCGUAUACGUA-CAA-GCAGU-AGGAGCGAAU----------AC A-------------------------------------------------G--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUGAU-UAGUUG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAUAAAUGU---AUAAAUAUU--CGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUCUGUAGCAA---GGUUAA-CUG--------------AUU----- ---------AAG-G-G-A-GCCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAC--------------- -------------------------------------------U--GGCG---------- ----------------------------------------UU------------------ ------------------------AAGUUGCAGGAUAUA-GACCCGAAACCCG-GUGAUC UAACCAUGAACAGGUUGAAGAUUGG-GUAAUAC-UAAUUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGAUUUGUGGUUAGGGGUGAAAGACCAAUCAAACCGGG-A GAUAGCUGGUUCUCCUCGAAAGCUAUUUAGGUAGCGCCUUGUA-A--------------- ------------------------------------------------------------ --------------------AUUC-AU-CUUUGGGGGUAGAGC-ACUGUUUCGA--UU-A GG--G-GUU-C-AAACC-GAGCUA-CCAACUCGAUGCAAACUACGAAUACCAA-AGA-A- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------UU--AU--U-ACUGG-AGA-CAC-ACA--GC-GGGUGCUAACAUUCGU-UG -UGGAAA-GGGAA----ACA--ACCCAGAUCGCU-AGCUAAG--GUCCC--UAAGUU--A U-G-AU-U-AAG--UGGGA-----------AACGAUGUGAGAAGGCAUAAACAGCCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGGCUUGCGCGGAAGAUGUAACGGGGCU--A-AAUCA---UAC--------ACC--G AAG-CUGCGAC--AAU---A--G----AA-C---------------AU-U---------- ----UACUAUU----UUUAUUUUAAUU--------------------------------- ------------------------------------------------------------ -------------AAAUUAAAAUUUAUAUUUAUAUAAAAAUAUAAAUAAGUUGAAAUA-A A--AUGGGUGA----AG----U---------GUUU-U-G-U-UG-GG--UAGAG----GA ---G-CGUU-CUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GAGA AGAUA-U--A-UUGU-GA-GAU--AUAU-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-AAGUA-ACG-A--UAA-AGCAG-G------------------UGAAAAA----- ----------CCUGCU-CGCC-GAA-AAACU-AAGGUUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UAAGUCGACCC-C-UAA----GGUG-A-GGCCAAA--CGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CU---AA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-G-GA-U--GUAA-U-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-UA-AC--GGAG-A AAGCUA--GG--U-UC-GC-C-GAG---GAU--CGG-----UAGU--CU-CGG-U-UU-- -A------AGC------AA-G------U------A---G----A---U-----G-----A G-AA-----G---AUAUA-G--G-----A--AAA-U-CCG-AUCUU-CU-----UUAC-A -UU-A--A-GA-U--G--U-G--A-UG-A-CGA--GC-UGC------------------- ---------UA-CG--------------------------------GU-AGC--GAA--G GA-A----UU-GAUGC-UAUG---CUUC-CAAGAAA-A-A-CCUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--AU-U-AUA--UC-C-AAUCGUACCGUAAACCGACACAGGUAGUUA-GGU-AGAGAA -U-ACUAAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UAGUGCCG UAACUUUGGG-AGAAGGCACGC-UA-AC-AUGUA-AGUGAAG-GG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G U--AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UUC-U-G----- G-----AGC-U-G--A-AGUUA-GUCGAAGAUACCAGCUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUGUGC-AAACAC--GA---A-A------------GUGGAA-GU-AU ACAGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAGAUGGUU-AUCUUU--GCA A---AAAGAG-AAGCUUUUGAUCGAAGCCUCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GUCAG--ACUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAAUU-CGCCGUGAA GAUGCGGCGUACCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGAU ACUGAAUGUUGGAUUUUAAUGUGUAGGAU-AGGUGGGAG-GC-UA-U-GAA--AUA--AA GAC--------------------------------------------------------- ----------------------------------GCUA--GUUUU--UAUGGAGC--CG- UCCU-UGAAAUA-CCACCCUUUGAUG-UUUAAUAUUCUAA-CUUUA--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUU-AAGGA -CAG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCUA-AAGAGUAAC-GGAGG AGCACAAAGGUUAGCUAAUUACGGUUGGAAAUCGUAAGGU-UAGUGC-AAAGGCAUAA-G CUAGCUUAACUG-CGAGAGUG-A----CGAUUCGAGCAGAUGCGAAAGCAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UCCUG--UAU-GGA- -----------------------------AAGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUAAUACCGCCCAAGAGUUCGUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGCAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAAGA-UUGAGAGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGUAC CUA-UGGUGUU-CGGGU-UGUCAUGCCAAUGGC-AU--UGCCCGGUAGCUA-U-GUACGG AAA-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------UGC-CUCAAGA--- --UGAGUCU---------------------------UC--CCU--------GA-G--G-- A--UU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUUAAUUAC------------------------ ------AAU-CCUC-CUAA---AGGGC---CGUU--A-AAGACUAUGA-CG-UUGAUAGG UCGGG-UGUGUAAG-CAU-U-------------------------GUGA----------- --GAUGU--U--UAGCU-----AACC----G-AUACUAA-UGACCC-GU--GAGAACUUA -ACUUC-- >Bradyrhizobium_japonicum --AAUCAAGU---GCCUUAAGGGUGUUC-GGUGGAUG-CCU-UGGCG-CUG-A--GAGGC GAUGAAGGACGUGCU-ACGCUGCGAUAAGCCGUGGGGAGCUGCGAA-GA-AGCUUU-GAU CCGCGGAUUUCCGAAUGGGGAAACCCACCUUCGAUAGCCGGAACU-CCAAGACCUUUGUC GAAAGACAUCGGU--GUGGGGU-----UCGACCAGAUAAUGGAAGAUGCCUAGGCC-UUU AGAUUUCG-------AUCGAAGAGGUUUUGGAUUUCCGGUUAUCAAGAGAAGGUAUGAGA CUUCU--------------------------GAAUACAU-A------------------- ---------------GGAGGUUUCAAGCAA-ACCCAGGGAACUGAAACAUCUAAGUACCU --GGAGGAAAGGACAUCAA-CAGAGACUCCGUUAGU-AGU-GGCGAGCGAACGCGG-ACC AGGCCAGU-GA-UAC------------------------------AU-C----------- ------------------------------------------------------------ -------------------A-------------AAGACAAU------CGG-AACCA-GUC AG-GA-------AAGCU------G-GGCC-UCAGAGGGUGAUAGCCCCGUACGAGUAAUG -C-G-A-UG---------A---------UGUA-----UCCACGAGUAAGGCGGGACACGU GCAAUCCUGUCUGAACGCGGGGGGACCA--CCCUCCAAGCCUAAGUACUCC-UC-AGCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGACGAGGGGAGU GAAAUAGACCU-GAAACCGGACACCUA-CAA-ACAGA-UGGAGCCCAA----------GA U-----------------------------------UCGUUCUG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACAUCGUACCUUUUGUAUUAUGGGCCAG CGACUUAA-U----UUAACGAGCAA---GCUUAA-GCC--------------GAUA---- ---------GGC-G-A-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UC------------------ ------------------------AAGUUCGUUGUAUUA-GACCCGAAACCUA-GUGAUC UAGCCAUGAGCAGGUUGAAGGUGAG-GUAACAC-UCACUGGAGGACCGA--ACGG-GUGC -CUGUUGAAAAAGGCUCCGAUGACUUGUGGUUAGGGGUGAAAGGCCAAUCAAACUGGG-A AAUAGCUGGUUCUCCGCGAAAGAUAUUUAGGUAUCGCCUCGGA-U--------------- ------------------------------------------------------------ --------------------GAAU-AC-CUCAGGGGGUAGAGC-ACUGGAUGGG--CU-A GG--G-GGA-C-UUACC-GUCUUA-CCAAACCCAACCAAACUCCGAAUACCUG-AGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--U-CCGGG-AGU-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGGAGA-GGGAA----ACA--ACCCGGACCUAC-AGCUAAG--GCCCC--UAAUUC--G U-G-GC-U-AAG--UGGGA-----------AAGGAUGUGGAAAUCCCAAAACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAACAGCUCACUGGUCUAAAUA AGGGUUUCUGCGCCGAAGAUGUAACGGGGCUC-A-AGCCA---CGA--------GCC--G AAG-CUUAGGG--UGU---G--A----UC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- -------------------------------GGGU-C-A-C-GC-GG--UAGCG----GA ---G-CGUU-CUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGGC-G-AC-UCGU-GA-GAG--CGCC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GGCAU-GAGUA-ACG-A--CAA-ACACU-G------------------UGAAAGA----- ----------CAGUGU-CGCC-GAA-AGUCC-AAGGGUUCCU-GCGUAAAGUUAAUCUUC GCAGGG------------UUAGCCGGUCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AUG-CAG--U GAA----UAUU-CUG----CAGCC-A-GU-G--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AU-GGU--G-AC--GAAU-C CCGUGU--GU--U-GU-CC-G-ACC-UUAA---UGG-----AUU---GG-UUG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GC-U----UC----GAAG-GG---GUUC-CAGGAAA-U-A-GCCU---C--C-------- ------------------------------------------------------------ ---------ACA--UU-A-GACCGUACCCGAAACCGACACAGGUGGACU-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAACUAU-GUUGAAGGAACUCGGCAAUU-UACCUCCG UAACUUCGGG-AUAAGGAGGCC-CA-UU-----------GCU-CG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCG-G-G----- C-----------------AGUG-GGGGCACAGACCAGGGGGUGGCAA-----CUGUUUAA CAAAAACACAGGGCUCUGC-GAAAUC--GC---A-A------------GAUGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGAGGAGAGGU----------GCA A------------GCCUUGAAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AC-U--UCCCC--GCUGUCUCCA-AC-AUA-GACUCAGUGAAAUUGAAUU-CCCCGUGAA GAUGCGGGGUUCCUGCGGUCAGACGGAAAGA-CCCCGUGCACC-UUUACUGUAGCUUUGC GCUGGUAUUCGUGACUGUUUGUGUAGAAU-AGGUGGUAG-GC-UU-U-GAA--GCC--GU GGC--------------------------------------------------------- ----------------------------------GCCA--GCCAU--GGUGGAGC--CG- AAAUGUGAAAUA-CCACCCUAAUGGU-UAUGGAUAUCUAA-CCGCG--UU--------CC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-CAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GG-G-AAC-CGGGA -CAG-CGCAUGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCCA-AAGAGUAAC-GGAGG CGUGCGAAGGUAGGCUCAGAACGGUCGGAAAUCGUUCGUC-GAGUAU-AAUGGCAUAA-G CCUGCCUGACUG-CGAGAUCU-A----CGAAUCGAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--CGU-GGA- -----------------------------UGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUGACGCCCAAGAGUCCAUAUCGACGGCGUCGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGAAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGUGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----UGGAAUG-UUGAGAGGAU--UUGCCCCUAGUACGAGAGGACCGGGGUGAACGUAC CUC-UGGUGGA-GCUGU-UGUCGCGCCAGCGGC-AG--UGCAGCAUAGCUA-U-GUACGG ACG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACC------CAC-CUCAAAA--- --CGAGCAU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CU-U--GAGAAC---CGUG--G-AAGACCACCA-CG-UUGAUAGG CCGGA-UGUGGAAG-UGC-A-------------------------GUAA----------- --UGCAU--G--CAGCU-----UACC----G-GUACUAA-UCGUUC-GA--UUGG-CUUG -AUUGC-- >Buchnera_aphidicola --GGUUAAGC---AA-AUAAGCGUACAU-GGUGAAUG-CCU-UGGCA-GUC-A--GAGGC GAAGAAGGACGUGCU-AAUCUGCGAAAAGCGUCGGCAAGCUGAUAUGAA-GCGCAA-UAA CCGUCGAUAUCCGAAUGGGGAAACCCGAUGCAAUA------------------------- ---------------UU------------------------------------------- -----------------------------------GC-AUCA-------------UUA-U UAACU--------------------------GAAUCAAA-U---------------A--- ---------------AGUUA-AUAAAGCAA-ACCAAGGGAACUGAAACAUCUAAGUACCU --UGAGGAAAAGAAAUCAA-CCGAGAUUCCCCCAGU-AGU-GGCGAGCGAAAAGGG-AAC AGCCCA-G-AAUCAAA-AU-------------------------CAAUA----------- ------------------------------------------------------------ -------------------U-------A-----AAUUAUAG------UAG-AAUG--AUU UG-GA-------AAUUU------C-AGCG-AUACAAGGUGAUAGCCCCGUAUACAAAAUA ---UUU-UA---------U-------AUUGUG-GAUUC-AAAAAGUAGAGCGGGACACGA GAAAUCCUGUUUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACU-AGUACCGUAAGGGAAAGGCGAAA-AGAAC-CCCGGCGAGGGGAGU GAAAUAGAACCUGAAACCGUGUACGUA-CAA-GCAGU-GGAAGCAUAU----------UU UAAAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------UAAUU------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUGU-A----CUCUGUAGCAA---GGUUAA-CUU--------------AAU----- ---------AAG-G-G-A-GCCGAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CCU---------------------------------------AAA--------------- -------------------------------------------U-AGGCG---------- ----------------------------------------UU------------------ ------------------------AAGUUUCAGGGUACA-GACCCGAAACCCG-GUGAUC UAGCCACGGGCAGGUUGAAGGUUGG-GUAAAAC-CAACUGGAGGACCGA--ACCG-ACUG -AUGUUGAAAAAUCAGCGGAUGACCUAUGGCUAGGGGUGAAAGGCCAAUCAAACCGGG-A GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUG-A--------------- ------------------------------------------------------------ --------------------AUUC-AU-CUUCGGGGGUAGAGC-ACUGUUUCGA--CU-A GG--G-GGC-C-AUCCC-GGCUUA-CCAAACCGAUGCAAACUCCGAAUACCGU-AGA-A- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------UU--AU--C-ACGGG-AGA-CAC-ACA--GC-GGGUGCUAACGUUCGU-UG -UGGAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--AAAGUC--A U-A-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCAUAAACAGCCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----A AGUCGGCCUGCGCGGAAGAUGUAACGGGGCUC-A-AACUA---UGC--------ACC--G AAG-CUGCGGC--AGC---A--A----AA-A---------------U------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UAU------------------------------ ---------------------A---------UUUU-U-G-C-UG-GG--UAGGG----GA ---G-CGUU-CUGUAAG-------------------CC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------ACGA AGAUA-U--A-UUGU-AA-AAU--AUAU-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-ACG-A--UAA-AGCAG-G------------------UGAAAAA----- ----------CCUGCU-CGCC-GAA-AAACC-AAGGUUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UAAGCCGACCC-C-UAA----GGCG-A-GGCUGAA--AAGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-AGG--U UAA----UAUU-CCU----GUGCU-U-AA-U--AUUA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------AG-UGG-GG-AC--GAAG-A AGGUUA--AG--U-UA-UC-C-AGG--UGA---CGG-----UUAU--CC-UGG-U-UU-- -A------AAU------GU-G------U------A---G----G--UA-----U-----G A-U------A---AU-UA-G--G-----C--AAA-U-CCG-AUUAU-CU----UUAA--U -CU-G--A-GG-C--A--U-G--A-UG-A-CGA--AU-CAU------------------- ---------UA-AG--------------------------------GU-GAU--GAA--G UA-A----CU-GACAC-CACG---CUUC-CAAGAAA-A-G-CCUC---U--A-AGC-AU- CA---------------------------------------------------------- -G--GU-A-AAA--UU-A-AAUCGUACCCCAAACCGACACAGGUGGUUA-GGU-AGAGAA -U-ACUAAGG-CG-CU-UGAG-AGAACCCA-GGUGAAGGAACUAGGCAAAA-UAGUGCCG UAACUUCGGG-AGAAGGCACGC-UA-AU-GU-UA-AGUGAAA-GG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UCC-U-A----- U-----AGC-U-G--A-AGUUA-GUCGAAGAUACCAGCUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUGUGC-AAACAC--GA---A-A------------GUGGAA-GU-AU ACGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUCGAAGGAGUC-AAAG----GAA A-----CUUA-AAGCUCUGAACUGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAG--GCUGUCUCCA-CC-UGG-GACUCAGUGAAAUUGAAUU-UGCUGUGAA GAUGCAGUAUAUCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGAC ACUGAAUUCUGAAUUUUAAUGUGUAGGAU-AGGUGGGAG-GC-CA-U-GAA--GUU--AA AAC--------------------------------------------------------- ----------------------------------GCUA--GUUUU--AAUGGAGC--CA- AACU-UGAAAUA-CCACCCUUUAAAA-UUCGGUAUUCUAA-CCUAG--UG--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-CAC-AGAGA -CAG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGUACGAAGAUUGGCUAAUCACGGUCGGACAUCGUGAGGU-UAGUGC-AAAGGCAUAA-G CCAGUUUGACUG-UGAGCGUG-A----UAACGCGAGCAGGUGCGAAAGCAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAAGA-UUGAGGGGGG--CUGCUUCUAGUACGAGAGGACCGAAGUGGACGCAU CAC-UGGUGUU-CGGGU-UGUCAUGCCAAUGGC-AU--UGCCCGGUAGCUA-A-AUGCGG GAA-AGAUAAGCGCUGAACGCAUA--U-AAGCACGAAACU------UGC-CCCAAGA--- --UGAAUCU---------------------------UC--CCU--------GA-A--A-- C--A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GAAA---------------------------- -------UG-UUUA-CUGA---AGGGA---CGUU--G-AAGACUACGA-CG-UUGAUAGG CUAGG-UGUGUAAG-CAU-A-------------------------GCAA----------- --UAUGU--U--GAGCU-----AACU----A-GUACUAA-UGACCC-AA--GAGG-CUUA -ACCUU-- >Burkholderia_sp. --GGUCAAGC---GA-ACAAGUGCAUGU-GGUGGAUG-CCU-UGGCG-AUC-A--CAGGC GAUGAAGGACGCGGU-AGCCUGCGAAAAGCUACGGGGAGCUGGCAAACA-AGCUUU-GAU CCGUAGAUGUCCGAAUGGGGAAACCCACUCCUUUU------------------------- ------------------------------------------------------------ ------------------------------------GGAGUA-------------UCC-A UGGCU--------------------------GAAUACAU-A------------------- ---------------GGCCAUGUGAAGCGA-ACGCGGUGAACUGAAACAUCUAAGUAACC --GCAGGAAAAGAAAUCAA-CCGAGAUUCCCAAAGU-AGU-GGCGAGCGAAAUGGG-AUG AGCCUUGC-ACUCUU-----------------------------UAUUU----------- ------------------------------------------------------------ -------------------G-------U-----AUUGUUAG------CCG-AACG--CUC UG-GA-------AAGUG------C-GGCC-AUAGCGGGUGAUAGCCCCGUAGGCGAAAAC -A-GUA-UG---------A-A----GGAACUAGGUGUGCGACAAGUAGGGCGGGACACGU GAAAUCCUGUCUGAAGAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCG-UG-AUCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAUCCUGAAACCGCAUGCAUA-CAA-ACAGU-CGGAGCC-------------UC GU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-G----UUCAGUAGCAA---GCUUAA-CCG--------------UAU----- ---------AGG-G-C-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------CAGUUGCUGGGCGUA-GACCCGAAACCAA-GUGAUC UAUCCAUGGCCAGGAUGAAGGUGCG-GUAACAC-GUACUGGAGGUCCGA--ACCC-ACUA -ACGUUGAAAAGUUAGGGGAUGAGCUGUGGAUAGGGGUGAAAGGCUAAACAAACUUGG-A AAUAGCUGGUUCUCUCCGAAAACUAUUUAGGUAGUGCCUCGUG-U--------------- ------------------------------------------------------------ ---------------------CUC-AC-CUUCGGGGGUAGAGC-ACUGUCAUGG--UUGG GG--G-GUC-U-AUUGC-AGAUUA-CCCCGCCAUAGCAAACUCCGAAUACCGA-AGA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------C---AAU-C-ACGGG-AGA-CAG-ACA--UC-GGGUGCUAACGUCCGG-UG -UCAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--CAAA-U--A U-A-GC-U-AAG--UGGGA-----------AACGAAGUGGGAAGGCUAAAACAGUCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUGAUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCU--A-AGCUA---UAU--------ACC--G AAG-CUGCGGA--UGC---G--U----GC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UU-U----------------------------- --------------------------------GCA-C-G-C-AU-GG--UAGGA----GA ---G-CGUU-CUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGUG-U--C-UCGG-AA-GGG--AUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--UAA-AGGGG-G------------------UGAAAGG----- ----------CCCCCU-CGCC-GUA-AGCCC-AAGGUUUCCU-ACGCAACGUUCAUCGGC GUAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCAGAA--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CU---GA--U-GGGA-AGC-AGG--U CAA----UAUU-CCU----GCACC-A-UU-G--UUAG-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GGAU-C GCGGAA--AG--U-UG-UC-C-GGG--UGU---UGGA----AGU---CC-CGG-U-CG-- -C------UGC------AU-U------G------G---A----G---A----------AG G-C------G---CU-UA-G--G-----C--AAA-U-CCG-GGCGC-GG------AAU-U -CA-A--G-GG-U--G--U-G----GC-G-CGA--GC-UCC------------------- ---------UU-AG--------------------------------GG-AGC--GAA--G CA-A----UU-GG-AA-G-UG---GUUC-CAAGAAA-A-G-CCUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UC-U-AAU--GA-U-GACCGUACCGCAAACCGACACAGGUGGGCG-AGA-UGAGUA -U-UCUAAGG-CG-CU-UGAG-AGAACUCG-GGAGAAGGAACUCGGCAAAU-UGGUACCG UAACUUCGGG-AUAAGGUACGC-CC-UU-GU-AG-CUUGAUG-CC-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C U--GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGG-C-A----- A-----AGG-G-U--G-AAGGG-GUUGCAAUAAACUGGUGGCUGCGA-----CUGUUUAA UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGAUUAAAUGAUGGGGU----------GCA A------------GCUCUUGAUUGAAGUCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCU-CC-CGA-GACUCAGCGAAGUUGAAGU-GUUUGUGAU GAUGCAAUCUACCCGCGGCUAGACGGAAAGA-CCCCAUGAACC-UUUACUGUAGCUUUGC AUUGGACUUUGAACCGAUCUGUGUAGGAU-AGGUGGGAG-GC-UA-U-GAA--ACC--GG AAC--------------------------------------------------------- ----------------------------------GCUA--GUUUC--GGUGGAGC--CG- UCCU-UGAAAUA-CCACCCUGGUUUG-UUUGAGGUUCUAA-CCUUG--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UG-AUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-GGGGA -CAG-UGCAUGGUAGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGCGUAAC-GGAGG AGUACGAAGGUACGCUAGGUACGGUCGGAAAUCGUGCUGA-UAGUGC-AAUGGCAUAA-G CGUGCUUAACUG-CGAGACCG-A----CAAGUCGAGCAGGUGCGAAAGCAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCUCAUCCUGGGGCUGUAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGAGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAUAU-UUGAAGGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUA-CCGGU-UGUCACGCCAGUGGC-AU--CGCCGGGUAGCUA-U-GUUCGG AAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------CGC-CUUAAGA--- --UGAGAUA---------------------------UC--CCU--------GG-G--G-- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUAGA---------------------------- --------U-CCCC-UUGA---AGGGU---CGUU--C-GAGACCAGGA-CG-UUGAUAGG UCAGG-UGUGUAAG-CGC-A-------------------------GUAA----------- --UGCGU--U--CAGCU-----AACU----G-AUACUAA-UUGCCC-GU--AAGG-CUUG -AUCCU-- >Caulobacter_crescentus --GAUCAAGC---GC-AUAAGGGCUUCU-GACGGAUG-CCU-UGGCA-UUG-A--GAGGC GAUGAAGGACGUGGC-ACGCUGCGAUAAGAGCCGGGGAGGCGCGAG-CA-CCCUUU-GAU CCGGCUAUCUCCGAAUGGGGAAACCCACCUUUAUGGUCAC----C----CG-ACUUUG-- ------------U--UUCCGCU-----UCGGCG--------------------------G AGACGACG-------AU-------------------CGGUUGAUCAGACAAGGUAUAA-U GACCU--------------------------GAAUACAU-A------------------- ---------------GGGUUCAUUAAGCAA-ACCCGGGGAACUGAAACAUCUCAGUACCC --GGAGGAAAGGACAUCAA-CCGAGACUCCCGUAGU-AGU-GGCGAGCGAACCGGG-ACC AGGCCAGU-GC-UGU------------------------------CG-U----------- ------------------------------------------------------------ -------------------G-------------ACAUAAAG------CUG-AAUGU-GUU GG-GA-------AA-CA------C-AGCC-AUAGUGGGUGAUAGCCCCGUAAGCGUCAAA -U-A-G-CG---------A-----------CA-----GACUCGAGUAGGGCGGGACACGU GAAAUCCUGUCUGAACAUGGGGGGACCA--CCCUCCAAGCCUAAGUACUCC-UC-AAUGA CCGAUAGC-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGACAAGGGGAGU GAAACAGAACCUGAAAUCGGAAGCCUA-CAA-GCAGU-CGGAGCCAC------------- -----------------------------------------------CGC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGU--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGACUUCA-U----GUGCCGUGCAA---GCUUAA-GCC--------------GUUA---- ---------GGU-G-U-A-GGCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AAU------------------ ------------------------AAGUACGUCGCAUGACGACCCGAAACCAG-GUGAUC UAUCCAUGAGCAGGUUGAAGGUAAG-GUAACAC-UUACUGGAGGACCGA--ACCG-GUGA -AUGUUGAAAAAUUCUCGGAUGACUUGUGGAUAGGGGUGAAAGGCCAAUCAAACCUGG-A CAUAGCUGGUUCUCCGCGAAAACUAUUUAGGUAGUGCCUCGGA-C--------------- ------------------------------------------------------------ --------------------GAAU-UC-CUUGGGGGGUAGAGC-ACUGAAUGGA--UG-C GG--G-CGG-C-GCGA--GCUGUA-CCAAUUCUAAUCAAACUCCGAAUACCCA-AGA-G- A-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--U-CCGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAAA-GGGAA----ACA--ACCCUAACCAUC-AUCUAAG--GCCCC--CAAGUA--C U-G-GC-U-AAG--UGGGA-----------AACGAUGUGGGUUUGCUUUGACAACCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAACAGCUCACUGGUC-----A AGCGAACCUGCGCGGAAAAUGUAACGGGGCUA-A-AGCCA---GUC--------GCC--G AAG-GUAUGGG--UGU---G--C----AC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UCU------------------------------ --------------------------------GUG-C-A-C-GC-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGUG-A--G-GCGU-GA-GCC--UUGC-U-GGA-GGUAUC-G--GAAGUGAGAAUGC-U GACAU-GAGUA-GCG-A--UAA-AGAGG-G------------------UGAGAGA----- ----------CCCUCU-CGCC-GAA-AGCCC-AAGGGUUCCU-GCGUAAAGCUAAUCUGC GCAGGG------------UUAGUCGGCCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AUC-AGG--U GAA----UAUU-CCU----GAACC-A-GU-U--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GA-AGU--G-AC--GGAU-C UGGUAA--AU--U-GU-CA-G-GGC-UUAU---UGG-----AUU---GC-UCC-U----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GC-A----GU----GAAC-AG---GUCC-CUGGAAA-U-A-ACUC---C--A-------- ------------------------------------------------------------ ---------ACG--G--A-GACCGUACCCGAAACCGACACAGGUGGGCA-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAACUAU-GCUGAAGGAACUCGGCAAAU-UGCACGCG UAACUUCGGG-AUAAGCGUGAC-UC-UC-----------UUU-UG-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CCA-G-A----- U-----------------GAGA-GUGGCACAAGCCAGGGGGUAGCGA-----CUGUUUAU CAAAAACACAGGGCUCUGC-GAAGCC--GC---A-A------------GGCGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-C-UGAAGGUUAAAAGGAGGGGU----------GCA A------------GCUCUGAAUUGAAGCCCAG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--ACUGUCUCCA-GC-AUA-GGCUCAGCGAAAUUGAAUU-CCCCGUGAA GAUGCGGGGUUCCCGCGGUCAGACGGAAAGA-CCCUAUGAACC-UUUACUGCAGCUUCGC CUUGGCGUUAGCAGCAACAUGUGUAGGAU-AGGUGGGAG-GC-UA-U-GAA--ACU--CG GGC--------------------------------------------------------- ----------------------------------GCCA--GUUCG--AGUGGAGC--CA- UCCU-UGAAAUA-CCACCCUUAUUGU-UGCUGACGUCUAA-CCGCG--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-CGGGA -CAU-GGCGUGGCGGGCAGUUUGACUGGGGCGGU-CGCCUCCCA-AAGUGUAAC-GGAGG CGCGCGAUGGUGGGCUCAGACCGGUCGGAAAUCGGUCGUC-GAGUGC-AAUGGCAUAA-G CCCGCCUGACUG-CGAGACUG-A----CAAGUCGAGCAGAGACGAAAGUCGGCCAU-AGU G-AUCCGGUG-------------------------G---------UCCUG--CGU-GGA- -----------------------------AGGGCCAUCGCUCAACGAAUAAAAGGUACUC UAGGGA-UAACAGGCUGAUUUUGCCCAAGAGUCCAUAUCGACGGCAAAGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGUGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----ACGAGAC-UUGAGAGGAU--CUGUCCCUAGUACGAGAGGACCGGGAUGGACACAC CUC-UGGUGGA-CCUGU-CAUGGCGCCAGCUGU-GC--AGCAGGGUAGCUA-A-GUGUGG AAU-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------AAC-CUCAAAA--- --CAAGGUC---------------------------UC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------C--U--GAGAGC---CGUG--G-AAGACCACCA-CG-UUGAUAGG CCGGG-UGUGGAAG-UGC-G-------------------------GUGA----------- --CGCAU--G--GAGCU-----UACC----G-GUACUAA-UAGCUC-GA--UAGG-CUUG -AUCGU-- >Chlamydophila_caviae --GACCAAGU---UG-UUAAGAGCUAUU-GGCGGAUG-CCU-UGGCA-UUG-A--CAGGC GAUGAAGGAUGCGUU-UACCUGCAGUAAUCUUCGGCGAGCUGGUAU-AA-AGCUAU-GAC CCGGAGGUAUCCGAAUGGGGUAACCCGGUAGAUUAAUC---------------------- ---------------G-------------------------------------------- -----------------------------------UCUACCA-------------UUA-U AUACU--------------------------GAAUACAU-A------------------- ---------------GGUAU-AUAAAGCGACACCUGCUGAACUGAAACAUCUUAGUAAGC --AGAGGAAAAUAAAUCAA--AGAGAUUCCCUAAGU-AGC-GGCGAGCGAAAGGGG-AGA AGACCAAA-CCACG------------------------------CCUUUGGUGUGGGG-- -------------------------UUGUAGGGUCGAUAA-----C--------AUGAG- --AUCU------------UA-------------AGUUUUAG------UUG-AAUAC-UUC UG-GA-------AAGUA------G-AACG-AUACAGGGUGAUAGUCCCGUAAACGAAAGA -A-CAA-GA----------------GACUCUAUUCGAUGCCUGAGUAGGGCUAGACACGU GAAACCUAGUCUGAAUCUGGGGAGACCA--CUCUCCAAGUCUAAAUACUAG-UC-AAUGA CCUAUAGU-GAACC-AGUACUGUGAAGGAAAGGUGAAA-AGAAC-CCUUGUUAAGGGAGU GAAAUAGAACCUGAAACCAGUAGCUUA-UAA-GCGGU-CGGAGACCUA----------UA GC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------UUCC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UCGGAAGCC-AUG----------GUUGACGGCGUGCCUUUUGCAUGAUGAGCCAG GGAGUUAA-G----UUAAACGGCGA---GGUUAA-GGG--A-U---------CUAC---- -------AUUCC-G-G-A-GCCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU UUU---------------------------------------AAU--------------- -------------------------------------------A-GAGCG---------- ----------------------------------------UA------------------ ------------------------UAGUCGUUUGAUUUA-GACACGAAACCAA-GUGAGC UAUUUAUGACCAGGUUGAAGCAUGG-GUAAGAC-CUUGUGGAGGACCGA--ACCA-GUAC -AUGUUGAAAAAUGUUUGGAUGAGUUGUGAAUAGGGGUGAAAGGCCAAUCAAACUUGG-A GAUAUCUUGUUCUCUCCGAAAUAACUUUAGGGUUAGCCUCGGA-U--------------- ------------------------------------------------------------ -------------------AUUAA-GC-UUUUGGGGGUAGAGC-ACUGAAUUCU--AG-C GG--G-GGC-C-UACC--GGCUUA-CCAACGGAAAUCAAACUCCGAAUACCAA-AA--G- C-G--------------------------------------------------------- ------------------------------------------------------------ -------------AG--U-CCGGG-AGA-UAG-ACA--GC-GGGGGCUAAGCUUCGU-UG -UCGAGA-GGGGA----ACA--GCCCAGACCGCC-GAUUAAG--GUCCC--AAAUUU--U A-U-GC-U-AAG--UGAGU-----------AAGGAAGUGAUGAUUCUAAGACAGUUGGAA UGUUGGCUUAG-AGGCAGCAAU-CAUUUAAAGAGUGCGUAACAGCUCACCAAUC-----G AGAAUCAUCGCGCCAAUAAUA-AUCGGGGCUC-A-AGCAU---AAA--------ACC--G ACA-UCGCGGG--UGU---A--U----AU------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAU----------------------------- --------------------------------AUA-U-A-C-GC-GG--UAGGA----GA ---G-CGUA-GUAUUCA-------------------GC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUA-U--A-CCGU-AA-GGA--GUGC-U-GGA-GCGGAU-A--CUAGUGAAGAUCCAU GGCAU-AAGUA-ACG-A--UAA-AGGAA-G------------------UGAAAAU----- ----------CUUCCU-CGCC-GUA-AGCAC-AAGGUUUCCA-GGGUCAAGCUCGUCUUC CCUGGG------------UUAGUCGGCCC-C-UAA----GUCG-A-GGCACAA--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------AC---GA--U-GGAGCAAC-AGG--U UAAA---UAUU-CCU----GUACC-A-CC-U--AAAA-C-U------------------- --------------------------------------------------------UUAG CAA--------------------------------------------------------- ----------------------------------------UG-GAA-UG-AC--GGAG-U ACGUUA--AG--C-ACGCG-G-ACG--AU----UGGA-----AA---UG-UCC-G-UA-- -U------CAC------AA-U------G------A---G----A---C----------UG G-U------U---AG-UA-G--G-----U--AAA-U-CCG-CUAAC-AU------AAG-G -UU-A--G-GU-U--G--U-G--G-UU-A--AG--GG-AAAU-C---------------- ---------UU-CG---------------------------G-A--GG-AAC--UGAU-G GU-G----UA-GC-GC-AAUG---CUUU-CAAGAAAUA-A-UUUC---U--A--GC---- ------------------------------------------------------------ -U--GU-U-GAU--GG-U-GACCGUACC-UAAACCGACACAGGUGUGCG-AGA-UGAGUA -U-UCUAAGG-CG-CG-CGAG-AUAACUUU-CGCUAAGGAACUCGGCAAAU-UAUCCCCG UAACUUCGGA-AGAAGGGGAGC-CU-UC--U-AG-GGUGAUU-AC-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UUUC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGU-A-U----- G-----AGC-C-C--C-GGGAG-GCCGCAGAGAAAUGGCCCAGGCGA-----CUGUUUAA CAAAAACACAGCACUAUGC-AAACCU--CU---A-A------------GGGGAA-GU-AU AUGGUGUG-ACGCCUGCCCAAUGC-C-AAAAGGUUAAAGGGAUAUGUC-AGCC----GUA A-----GGCA-AAGCAUUGAACCCAAGCCCUG-G-UGAAUGG-CCGCCGUAACUAUAACG GUGCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGUGUAACG AU-C--UGGGC--ACUGUCUCAG-CG-AAA-GACUCGGUGAAAUUGUAGU-AGCAGUGAA GAUGCUGUUUACCCGCAAAAGGACGAAAAGA-CCCCGUGAACC-UUUACUGUACUUUGGU AUUGAUUCUUGAUUUGUUAUGUGUAGCAU-AGCCAGGAG-AC-UG-U-GAA--CAC--UC UUC--------------------------------------------------------- ----------------------------------GUCA--GGAGA--GUGGGAGU--CA- UCGU-UGAAAUA-CUGGUCUUAACAA-GUUGGGAGUCUAA-CAUAA--UU--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-AAU-AUGGA -CAU-UGCCAGACGGGCAGUUUUACUGGGGCGGU-AUCCUCCUA-AAAAGUAAC-GGAGG AGCCCAAAGCUUAUUUCAUCGUGGUUGGCAAUCACGAGUA-GAGCGU-AAAGGUAUAA-A AUAGGUUGACUG-CAAGACCU-A----CAAGUCAAGCAGAGACGAAAGUCGGGCUU-AGU G-AUCCGGCG-------------------------G---------UGGAA--AGU-GGA- -----------------------------AUCGCCGUCGCUUAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUCGCCACCAAGAGUUCAUAUCGACGUGGCGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGGAGAAGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGCGGUACGCGAGCUGGGUUCAAAACGUCGUGAGACAGUUUGGUCUCUAUCCUUUG --UGG--G-CGC------------------------------------------------ -----AGGAUAC-UUGAAAGGAG--CUGUUCCUAGUACGAGAGGACCGGAAUGGACGAAC CAA-UGGUGUG-UCGGU-UGUUUUGCCAAAAGC-AU--AGCCGAGUAGCUA-C-GUUCGG AAA-GGAUAAGCAUUGAAAGCAUC--U-AAAUGCCAAGCC------UCC-CUUAAGA--- --UAAGGUA---------------------------UC--CCU----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AUG---AGACU---CCAU--A-UAGACUAUGU-GG-UUGAUAGG UUGGG-UGUGUACG-CAC-A-------------------------GUAA----------- --UGUGU--U--UAGCU-----AACC----A-AUACUAA-UAAGUC-CA--UUGA-CUUG -GUUUU-- >Chlorobium_tepidum ----UUAAGU---U-ACUAAGGGCGUAC-GGUGGAUG-CCU-UGGCA-CAA-G--AAGGC GAUGAAGGACGUGGUUUAACUGCGAAAAGCUGCGGGGAGGCGUAAA-CA-GCCUG-AUAU CCGCAGAUCUCCGAAUGGGGCAACCCACCUCG-AUUG----------------------- ---------------AG------------------------------------------- ----------------------------------G-----AA-------------UCC-C G--------------------------------U-------------------------- ------------------AAUGGGAGGCUAA-CCCAGGGAAGUGAAACAUCUCAGUACCU --GGAGGAAAAGAAAACAA-AAGUGAUUUCCUGAGU-AGU-GGCGAGCGAAAAGGAA-CA AGCCCAAA-CCGGUGCCUGU-----------UUCGG-----------CAGCGCCGGGG-- -------------------------UUGUAGGACUCCAGCAC------------------ ----------GUGAC---AG--------C---GAGCGAUAG------CAG-AACU--ACC UG-GA-------AAGGU------A-GGCC-AAAGAAGGUGAAAGCCCUGUAAGCGAAAUC -G-CAA-AC---------UGC----ACA-GG---AGGAUCCUGAGUAGCACGGGGUACGU GAGGUCCUGUGUGAACCAGCGAGAACCA--UCUCGUAAGGCUAAAUACUCU-CU-UGUGA CCGAUAGU-GAACA-AGUACCGUAAGGGAAAGGUGAAA-AGUAC-CCUUAAGAAGGGAGU GAAAUAGUACCUGAAACCGUACGCUUA-CAAAACUGU-AGGAGCUAAC----------CC AC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----CAAGUGGGG--------------UGUGACUGCGUGCCUUUUGCAUAAUGAGCCUA CGAGUUACUG----GUGUGUUGCGA---GGUUAA-GGU--U-U---------UCA----- -------GAACC-G-G-A-GCCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU UCG---------------------------------------AAC--------------- -------------------------------------------A-GAGCG---------- ----------------------------------------G------------------- ------------------------GAGUAACAUGCCGUA-GACGCGAAACCAG-GUGAUC UAUCCUUGAUCAGGAUGAAGUAUGG-GUAAAAC-CAUAUGGAGGUCCGA--ACCA-GUGU -GGGUUGAAAACCGCUUGGAUGAAUUGAGGAUAGGGGUGAAAGGCCAAUCAAACUUGG-U GAUAGCUCGUACUCCCCGAAAUGUCUUGAGGGACAGCCUCGGG-G--------------- ------------------------------------------------------------ -------------------UCGAG-UC-UGCCGGAGGUAGAGCUACCAAUUGGG--CU-A GG--G-CUG-U-CACA--ACGGUA-CCAAACCCAGAUGAACUCCGAAUGCCGG-UAU-G- A-C--------------------------------------------------------- ------------------------------------------------------------ ----------A--UA--C-CCGGG-AGU-GAG-GGC--AU-GAGCGAUAAGGUCCAU-GU -CCGAGA-GGGAA----ACA--ACCCAGAGCCAC-AGCUAAG--GCCCC--CAAAUU--C A-C-GC-U-AAG--UGUAU-UA--------AAGAUUGUUUGAUUGCCCAGACAGCUAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAGAGUGCGUAAUAGCUCACUAGUC-----A AGCGAUCAUGCGUCGAUAAUAC-UCGGGACU--A-AGCGU---GGU--------GCC--G AAG-CUUGGUG--AUU---UC-U----UU-A---------------GG-C---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UACG----------------------------- ---------------GU----C---------UAAAUG-A-A-UC-GG--UAGGG----GA ---G-CAUU-CCAG-UU-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGGUG-A--G-UGGU-AA-CGC--UUGC-U-GGA-GCGGCU-G--GAAACGAACAUGU-A GGCAU-GAGUA-GCG-A--UAA-ACAAA-G------------------UGAGAAA----- ----------CUUUGU-CACC-GAA-AAUCU-AAGGUUUCCU-GAGCAAUGUUAAUCAUC UCAGGG------------UUAGUCGGGAC-C-UAA----GGUG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--U-GGAA-AAC-UGG--U UAA----UAGU-CCA----GUACC-C-AA-U--CAUG-A-A------------------- ---------------------------------------------------GGUUAUUAC CUA--------------------------------------------------------- ----------------------------------------UG-GGG-UG-AC--GCAG-A AGUGAA-AGG--A-GA-GC-C-ACC--GGA---CGGA----AGU---GG-UGG-U-UU-- -A------AGU------GC-G------U------A---G----G---C----------UG A-A------G---CG-UA-G--G-----C--AAA-U-CCG-CGCUU-CA----UCAAG-G -CC-G--A-AA-A--A--C-G--A-ACAG-GGC--GC-UC-------------------- ---------GU-AA---------------------------------G-AGCC-ACAA-C UC-U----CC-CUAAU-CCAG---CUGC-CGAGAAA-A-G-CCUC---U--C-UGG-GA- -C---------------------------------------------------------- -G--AC-A-UGA--CU-G-GCCCGUACCGUAAACCGACACAGGUAGAUG-GGA-UGAGUA -U-UCUAAGG-UG-CU-CGAG-UGAGACGC-AGCUAAGGAACUCGGCAAAA-UAGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-AG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A UUUU-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CUAG-GCCGCAGUGAAAUGGGUCAAGCGA-----CUGUUUAA CAAAAACACAUCUCUCUGC-CAAGAC--GAUUUA-A------------GUCGAU-GU-AU AGGGAGUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGGGGAUCUGUC-AGC-----GCA A------GUG-AAGCAGUGAACCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGUGUAACG AU-U--UGACC--ACUGUCUCGG-CU-GCG-CGCUCGGCGAAAUUGUAGU-GCCGGUGAA GAUGCCGGCUACUCGCAUCUGGACGGAAAGA-CCCUAUGCACC-UUUACUAUAACCUGGC AUUGGGCUUGAGCAUGAUUUGUGUAGAAU-AGGUGGGAG-ACUU--U-GAA--GCG--GG GAC--------------------------------------------------------- ----------------------------------GUCA--GUUUC--CGUGGAGU--CG- CAAUGUGAAAUA-CCACCCUGGUUGU-GUUUGAGUCCUAA-CCUCG--AC--------GA G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CAAAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CU-C-GUC-AGGGA -CCA-UGUCAGGCGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAAGUAAC-GGAGG CUUGCAAAGGUUCACUCAGUUCCGUCGGUAAUGGAACGUA-GAGCAU-AAUGGUAGAA-G UGAGCUUGACUG-UGAGACCG-A----CAGGUCGAGCAGGAACGAAAGUUGGCCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAUAGGAUAAAAGGUACGC UAGGGA-UAACAGGCUGAUCCCCGCCGAGAGUUCAUAUCGACGUGGGGGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGAAGGUCCCAAGGGUCCGGCUGUUCGCCGG UUAAAGUGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGAUG --CGA--G-CGC------------------------------------------------ -----AGGAAAU-UUGAGAGGGC--UUGUCCUUAGUACGAGAGGACCGGGACGAACAAAC CUC-UGGUGCA-CCAGU-UGUCACGCCAGUGGC-AU--GGCUGGGUAGCUA-U-GUUUGG UUG-AGCUAAGCGCUGAAAGCAUC--U-AAGUGCGAAACU------CGC-CUCAAGA--- --UGAGAUU---------------------------UC--CCC----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AUC---AGGCU---CCAG--G-AAGAUGACCU-GG-UCGAUAGG CUACA-GGUGUACG-CAC-A-------------------------GUAA----------- --UGUGU--U--UAGCC-----GAGU----A-GUACUAA-UAAGCC-GA--UCGA-CUUA -ACCAU-- >Coxiella_burnetii --GGUCAAGU---GA-AUAAGCGCAUAU-GGUGGAUG-CCU-UGGCA-GUA-A--GAGGC GAUGAAGGACGUAGU-AGCCUGCGAUAA-CUUCGGGGAGCUGGCAAACA-AGCGAU-GAU CCGGACAUUUCCGAAUGGGGAAACCCAACCU-----------------------U----- ---------------UC------------------------------------------- -----------------------------------GA-GGUU-------------AUG-U AUACU--------------------------GAAUUCAU-A------------------- ---------------GGUAU-ACGAGGCGA-ACCUGGGGAACUGAAACAUCUAAGUACCC --AGAGGAAAAGAAAUCAA-CCGAGAUUCCGUCAGU-AGC-GGCGAGCGAAA---G-AAC AGCCCAGU-UA-CUAA-AU-------------------------CAUUA----------- ------------------------------------------------------------ -------------------U-------U-----UGUUCUAG------CAG-AAUG--UUC UG-GA-------AAGUU------C-AGCC-AUAGCGGGUGAUAGCCCGGUACCCGAAAGA ---GUA-AA---------U-------AAUGUGGGUAAC-GAUGAGUAGGUCGGGACACGU GGUAUCUUGACUGAACAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UU-ACUGA CCGAUAGC-GAACC-AGUACCGUGAGGAAAGGUGAAAA-AGAAC-CCCGGCGAG-GGAGU GAAAUAGAACCUGAAACCGUAUGCGUA-CAA-GCUGU-AGGAGCAUUU----------CU ----------------------------------------UCGGAAA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-U----UGUUGUAGCGA---GCUUAA-CCG--------------UCU----- ---------AGG-G-G-A-GGCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAA--------------- -------------------------------------------U-GGGCG---------- ----------------------------------------UU------------------ ------------------------UAGUUGCAACGAGUA-GAC-CGAACCCGAAGCGAUC UAUCUAUGGCCAGGGUGAAGGUCAG-GUAACAC-UGACUGGAGG-CCGA--ACC--ACUA -AUGUGAAAAAGUUAGGGGAUGAGCUGUGGAUAGGAGUGAAAGGCUAAUCAAGCUCGG-A GAUAGCUGGUUCUCCUCGAAAGCUAUUUAGGUAGCGCCUCGUG-U--------------- ------------------------------------------------------------ ---------------------AUG-AC-UCUUGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGC-C-AUCCC-GGCCUA-CCAAACCGAGGCAAACUCCGAAUACCAA-GAA-G- U-U--------------------------------------------------------- ------------------------------------------------------------ ---------UU--AG--C-ACGGG-AGA-CAC-ACU--GCUGGGUGAUAAGGUCCGU-GG -UGGAAA-GG-AACGCCAGAUCG-CCAGAUCGC--AGCUAAG--GUCCC---AAAU---A C-ACG--U--AG--UGG-A-----------AACGAUGUGGGAAGGCUCAGACAGCCAGGA CCUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCCUAAUAGCUCACUGGUC-----G AGUCGUCCUGCGCGGAAGAUUUAACGGGGCUC-A-AACUG---UGU--------ACC--G AAG-CUGCG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------G-------------------------------- ---------------------------------------------GG--UAGAG----GA ---G-CGUU-CUGUAA--------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUG-A----UCGA-GA-GGU--UUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAUAAAGUA-ACG-A--UAA-UGUGG-G------------------UGAAAAA----- ----------CCCACA-CGCC-GAA-AGUCU-AAGGUUUCCU-GCGC--CGUUAAUC--C GCAGGG------------UGAGUCGGCCC-U-AAG----GGAG-G-AG---AA--AU-CG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUACU-U-UA-U--AAUA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UGGGGG-GGGAC--GGAG-A AGGCUA--GG--U-CA-GC-C-CCC--CGA---UGG-----UUGU--GGUGGG-C-UAGU CA------GCC------AC-C-GAUGUGUGUGUGUUAAGUGAUGUG-U-----A----GA ----------------AA-G--GAUCUUC--AAA-U-CCG-GAAC--UC------AAU-U -CC-G--A-GA-C--A--U-G--A-UG-A-CGA--GU-ACGAA----------------- ---------CU-UG-----------------------------UU-CG-UGC--AAA--G UG-A----UU-GAUGC-CACGA--CUUC-CAGGAAA-A-G-UCCC---U--A-AGC-UU- CA---------------------------------------------------------- -G--GU-A-UUG--UA-A-AACCGUACUAUAAACCGACACAGGUGGACA-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACUUG-GGUGAAGGAACUAGGCAAAA-UGGCACCG UAACUUCGGG-AGAAGGUGCGC-CC-UU--G-GUAAGUGAAG-GU-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GAC-U------- G-----AGC-U-G----AAA-G-GUUGCAGAUACCAGGUGGCUGCGAAAGACUAGUUUAC UAAAAACACAGCACUCUGC-AAACUC--GU---A-A------------GAGAGC-GUAAU AGGGUGUGAGCGCCUGCCCGGUGC-CGGAAAGGUUAAGUGAUGGGGUU-AGCC----CUC G-----GGCG-AAGCUCUUGAUCGAAGCCCCG-G-UAAACGGGCGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCAGU-GAAGUUCCGACCUGCACGAAUGGCGUAACG AU-A--GCCAC--GCUGUCUCCA-CC-CAA-GACUCAGUGAAAUUGAAAU-CGCUGUGAA GAUGCAGCGUACCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUACAGCUUUAC ACUGAACUUUGAAUAUGCCUGUGUAGGAU-AGGUGGGAG-GCUU--U-GAA--GCU--GG AGC--------------------------------------------------------- ----------------------------------GCUA--GCUCC--AGUGGAGC--CA- ACCU-UGAAAUA-CCACCCUGGCGUG-UUUGAGGUUCUAA-CCCUG--UC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-GGGAA -CAG-UGUAUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCUA-AAGAGUAAC-GGAGG AGUACAAAGGUACCCUCAGCACGGUCGGAAAUCGUGCAUU-GUGUGC-AAAGGCAUAA-G -GUGCUUGACUG-CGAGACGU-A----CAAGUCGAGCAGGUACGAAAGUAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UCCUU--UAU-GGA- -----------------------------AGGGC-A-CGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCACCCAAGAGUUCAUAUCGACGGUGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGUAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGUGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG -UUGG--G-CGU------------------------------------------------ -----UGGAGAU-UUGAGAGGAG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGUAC CUC-UGGUGUU-CCGGU-UGUCACGCCAGUGGC-AUU-UGCCGGGUAGCUA-A-GUACGG ACG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACC------C-C-CUCAAGA--- --UGAGAUC---------------------------UC--CG---------GA-C--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUAA---------------------------- ----------GGUC-CUAA---AGAUU---CGUU--G-AAGACGACAA-CG-UUGAUAGG CAGGG-UGUGGAAGUCUC-A-------------------------GUAA----------- --UGAGU--G--AAGCU-----AACC----U-GUACUAA-UUAAUC-GU--GCGA-CUUG -ACUAU-- >Crocosphaera_watsonii ----------------CAAAGGGCUAAC-GGUGGAUA-CCU-AGGCA-CAC-A--GAGGC GAAGAAGGACGUAGU-UACCGACGAUACGCUCCGGGGAGCUGGAAG-CA-AGCAU-UGAG CCGGAGAUUUCCCAAUGGGGCAACCCCAA-GA-ACGG----------------------- ---------------UC------------------------------------------- -------------------------------------------------------ACC-U -------------------------------GAAUCUAU-A------------------- ---------------GGGUGAUGCGAGCGA-ACUGGGCGAACUGAAACAUCUUAGUAACC --CAAGGAAGAGAAAGCAA-AAGCGAUUCCCCUAGU-AGC-GGCGAGCGAAGAGGGA-CA AGCCUAAA-CCAUCGA--C------------UA-----------AG--GUUGAUGGGG-- -------------------------UUGUGGGACAGUGAC-------------------- -----GUGGACU-------G--------U---AGCGGUUAA------ACG-AAGC--AGC UG--A-------AAACU------G-CACC-AGAGAAGGUGAAAGUCCUGUAGUUGAAAAC -U-UAA-GC---------A-G----CCUAAC---UGUAUCCCGAGUAGCACGGAGCCCGU GGAAUUCCGUGUGAAUCAGCGAGGACCA--CCUCGUAAGGCUAAAUACUCC-UG-UGUGA CCGAUAGA-GAAAC-AGUACCGCGAGGGAAAGGUGAAA-AGAAC-CCCGG-AAGGGGAGU GAAAUAGAACAUGAAACCGUUAGCCUA-CAA-GCAAU-GGGAGGACGA----------UU U-------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCUGACCGUGUGCCUGUUGAAGAAUGAGCCGG CGACUUAC-A----GGCUGUGGC-A---GGUUAA-A-U--G-----------GGA----- -------UGACC-G-A-A-GCCAAAGUGAAA-GCG------------------------- ---------------------------------------------------------AGC CUG---------------------------------------ACA--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------A------------------- ------------------------UAGUCACAGUUUGUA-GACCCGAACCCGG-GUGAUC UAACCAUGGCCAGGAUAAAGCUAGGGU-AAUAC-CUUGUGGAGGUCCGA--ACCG-ACUU -CUGUUGAAAAAGGAGCGGAUGAGCUGUGGUUAGGGGUGAAAUGCCAAUCGAACCCGG-A GCUAGCUGGUUCUCCCCGAAAUGCGUUUAGGCGCAGCGGUUGU-G--------------- ------------------------------------------------------------ -------------------UAC-C-UU-AUGGGGGGGUAAAGC-ACUAUUUCGC--UG-C GG--G-CUG-C-GAGA--GCGGUA-CCAAAGCGAGAUAAACUCAGAAUACCCU-GU--A- A-G--------------------------------------------------------- ------------------------------------------------------------ -------------CA--U-CAACC-AGU-GAG-ACG--GU-GGGGGAUAAGCUUCAU-CG -UCGAAA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--CAAAUA--A A-U-AC-U-AAG--UGAUA-----------AAGGAGGUGGGAGUGCAUAGACAACCAGGA GGUUUGCCUAG-AAGCAGCAAU-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGCGCUCCUGCGCCGAAAAUG-AACGGGGCU--A-AGUAU---UUU--------ACC--G AAG-CUGUGGA--CUU---A--A----UU-A---------------UU-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AUUGUUAA---------------------------- -------------------------------UUAU-U-A-A-UU-G---UAGGG----GA ---G-CGUU-CUGUAUA-------------------GG-G-------------------- ------------------------------------------------------------ ---------------------------------------------------------UGA AGCAC-U--A-GCGGCAA-GCA--GGUG-U-GGA-CAGUAC-A--GAAGUGAGAAUGU-C GGCUU-GAGUA-GCG-A--AAA-UAUAU-G------------------UGAGAAU----- ----------CGUAUA-CCCC-GAA-AUCCU-AAGGGUUCCU-CCGGAAGGCUCGUCCGC GGAGGG------------UUAGUCGGGAC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAA-ACA-AGG--U UAA----UAUU-CCU----UGACU-G-UG-A--UGAG-G-G------------------- -----------------------------------------------------------A GUU--------------------------------------------------------- ----------------------------------------UU-UAG-GG-AC--GCAU-G ACGAUU--AG--U-CA--U---------------------------------A-C-CC-- -U-------G-------A------------------------------------------ -----AUGG--------------------------------------------------- ------------A-----U------UG-G-GAG--GA-GAC------------------- ---------UA-CG--------------------------------GU-CUC--UGC--A UG-A-----U-GA-AC-AAUA---GUGC-CAAGAAA-A-G-CUAA---U-AA-ACG-UU- -G---------------------------------------------------------- -A--AC-U-CAU--GA-C-ACUCGUACCCGAAACCGACACAGGUAGGAA-GGU-AGAGAA -U-ACUAAGG-GG-CG-CGAG-AUAACUCU-CUCUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-CA-CC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GGUG-GUCGCAGUGAAUAGGCCCAGGCGA-----CUGUUUAC CAAAAACACAGGUCUCUGC-CAAGUC--GU---A-A------------GACGCA-GU-AU AGGGGCUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGGAAGUUGGUU-AGU------UU -----CGACG-AAGCUAGCGACCGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAACG AU-C--UGGGC--ACUGUCUCGG-AG-AGA-GGCUCGGCGAAAUAGGAUU-GUCUGUGAA GAUACGGACUACCUGCACCUGGACAGAAAGA-CCCUAUGAAGC-UUUACUGUAGCUUGGA AUUGGGUUCGGGCUUCCUUUGCGCAGCAU-AGGUGGGAG-GC-GU-U-GAA--GUU--UU CCU--------------------------------------------------------- ----------------------------------CGUG--GGGAG--AAUGGAGC--CA- ACGG-UGAGAUA-CCACUCUAGGGAG-GCUAGAAUUCUAA-CUUAA--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUU-AAGAA -CAG-UUUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCGCAAAGGUUCCCUCAGGCUGGUUAGAAAUCAGCCGCA-GAGUGC-AAAGGCAGAA-G GGAGCUUGACUG-CGAGACAA-A----CAAGUCAAGCAGGGACGAAAGUCGGCCUU-AGU G-AUCCGACG-------------------------G---------CACCG--AGU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGUUACUC UAGGGA-UAACAGGCUGAUCUCCCCCAAGAGUUCAUAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAGCCUGGGGCUGUAGUAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCAUAUCCGGUG --UAG--G-CGU------------------------------------------------ -----AAGAGCA-UUGAGAGGAG--CCUUCCUUAGUACGAGAGGACCGGGAAGGACGCAC CGC-UGGUGUA-CCUGU-UAUCGUGCCAACGGU-AA-ACGCAGGGUAGCCA-A-GUGCGG -AGCGGAUAACCGCUGAAAGCAUC--U-AAGUGGGAAGCC------CAC-CUCAAGA--- --UGAUUGC---------------------------UC--UCA--------CA-G--G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUUA----------------------------- --------A-CCUG---GU--AAGGUC---ACGG--G-AAGACCACCC-GU--UAAUAGG CACUC-GGUGGAAG-UCC-A-------------------------GCAA----------- --UGGAU--G--AAGCC-----AAGG----U-GUACUAA-CAGACC-GA---GGG-CUUG -ACCU--- >Cytophaga_hutchinsonii ---AGAAAAU---A-AAUAAGGGCGUAU-GGGGAAUG-CCU-AGGCU-CUC-A--GAGGC GAAGAAAGACGUGCC-AAGCUGCGAAAAGUUACGGGGAUCUGCUGA-GG-AGAUUU-GAU CCGUAAAUGUCUGAAUGGGGCAACCUGGUAUGUUGAA-------------G--------- ------------------------------------------------------------ -------------A---------------------CAUAUCG-------------ACC-- ---------------------------------AG------------------------- ------------------CAAUGGUAGCGA-ACCCGGUGAACUGAAACAUCUAAGUAACU --GGAGGAAGAGAAAAUAACUAAUGAUUCCCUAAGU-AGU-GGCGAGCGAACAGGG-AAG AGCCCAAA-CC-AAUG-UUGUUA---------------------CGGCAAUAUUGGGG-- -------------------------UUGUAGGACCGCAUUUAAGAG--------AAGUA- --AUUG--------------------------------AAC------UGG-AAAU--GUC UG-GG-------AAGGC------A-UGCC-AUAGCGGGUGAGAGCCCCUUACAGGUAAGA -U-UA--UC---------AUU--------UGAGCGGUAUCCUGAGUAGGGCGGGACCGGA GAAAUCCCGUUUGAAACUGCCGGCACCA--UCCGGUAAGGCUAAAUACUCC-UG-AGAGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-CCUGAAUAAGGGGGU GAAAUAGAACCUGAAACCAUACGCUUA-CAA-GCGGU-CGGAGCC-------------CU UA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AUGG--------GGUGACGGCGUGCCUUUUGCAUAAUGAUCCUA CGAGUUACUC----CUCACUGGCAA---GGUUAA-GCA--C-U---------UUUA---- -------GGUGC-G-U-A-GCCGGAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------CGU------------------ -------------------------AGUCAGUGGGGGUA-GACGCGAAACCUU-GUGAUC UACCCAUGGCCAGGAUGAAGUUGCA-GUAACAU-GCAAUGGAGGUCCGA--ACUG-GUAA -ACGUUGAAAAGUUUUCGGAUGAGCUGUGGGUAGGGGUGAAAGGCUAAUCAAACUGGG-A AAUAGCUCGUACUCCCCGAAAUGUAUUUUGGUACAGCGUCGGG-G--------------- ------------------------------------------------------------ -------------------UAAAG-UU-UAGCGGAGGUAGAGCUACCAAUAGGA--CU-A GG--G-GGA-G-UCAA--AUCCUA-CCAAAUCCUGAUGAACUCCGAAUGCCGC-UA--A- A-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UA--C-CCGGC-AGU-GAG-GGC--UU-GGGUGCUAAGGUCCAA-GU -CCGAGA-GGGAA----AGA--ACCCAGA-CUAACAGCUAAG--GUCCC--AAAAUC--U A-U-CC-U-AAG--UUGAA-CA--------AAGGAGGUCCAGUUGCAGAGACAGCCAGGA UGUUUGCUCGG-AAGCAGCAAUUCAUUUAAAGAGUGCGUAACAGCUCACUGGUC-----G AGCGACAGGGCAUCGAUAAUA-AACGGGCAUC-A-AGGGU---AGU--------ACC--G AAG-CUUUAGA--UUU---A--U----AC-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUA------------------------------ -------------------------------GGAG-U-A-A-GU-GG--UAGGG----GA ---G-CAUU-CCAAG-G-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGCG-A--A-ACGC-GA-GUU--UUGC-U-GGA-GGGCUU-G--GAAAAGCAAAUGU-A GGAAU-AAGUA-ACG-A--UAA-UAAGG-G------------------UGAGAAU----- ----------CCCUUA-CACC-GAU-AGACU-AAGGUUUCCU-GAUCAACGUUCGUCGGA UCAGGG------------UUAGUCGGGAC-C-UAA----GGCA-A-AUCCGU----GGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-UGG--U UAA----UAUU-CCA----GUACU-U-GU-G--UAUA-C-U------------------- -----------------------------------------------------------G CUA--------------------------------------------------------- ----------------------------------------UG-GAG-AG-AC--GGAG-U AGUGAA--AA--G-UUCGC-C-UGG--UGA---CGGA----AUA---CC-AGG-U-UA-- -A------AAC------CC-G------U-A---GA---U----A---U-----A----UU U-U------G---AG-UA-G--G-----C--AAA-U-CCG-CUCGA-GA------U---G -UC-G--A--A-G--G--U-G--A-UA-G--UA--CA-ACAAA-GC-------------- ---------UU-CG-------------------------GC-AG--CG-UUG-AUA---- GU-GA---CU-GUAAA-C-AG-A-CUUC-CAAGAAA-A-U-CUUC---U--A-UGC-UU- CA---------------------------------------------------------- -G--GU-A-UAU--AC-G-ACCCGUACCGCAAACCGACACAGGUAGUCA-AGG-AGAGAA -U-CCUGAGG-UG-CG-CGAG-UGAUUCAC-GGCUAAGGAACUCGGCAAAU-UAACCCUG UAACUUCGGG-AGAAGGGGUGC-UU-CC-UCUA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------U-GAGAA-GCCGCAGUGAAAAGUCUCAGGCGA-----CUGUUUAA CAAAAACACAUGGCUCUGC-GAAAUC--GA---A-A------------GAUAAA-GU-AU AGGGCCUG-ACACCUGCCCGGUGC-C-GGAAGGUUAAGAGGGGGGCUU-AGC-----GUA A------GCG-ACGGUCUGAAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGUGUAACG AU-C--UGAGA--ACUGUCUCAG-CC-GUG-AGCUCGGUGAAAUUGUAGU-AGCGGUGAA GAUGCCGCUUACCCGUCACGGGACGGAAAGA-CCCCGUGCACC-UUUACUAUAGCUUUGC AUUGAUUUUGGGUAAAUGAUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GCG--GG UAC--------------------------------------------------------- ----------------------------------GCUA--GUAUU--CGUGGAGC--CA- ACGU-UGAAAUA-CCACCCUUUAUUU-ACUUGGAGUCUAA-CCC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAUA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GGAAA -CAG-UGCAUGGUGGGUAGUUUGACUGGGGUGGU-CGCCUCCAA-AAAAGUAUC-GGAGG CUUCUAAAGGUUCCCUCAGUACGCUUGGUAACCGUACGUA-GAGUGC-AAUGGCAUAA-G GGAGCUUGACUG-UGAGACAA-A----CAAGUCGAUCAGGUACGAAAGUAGAGCAU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAAAGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGCUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCGUCACAUCCUGGGGCUGGAGAAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGUGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGUGA --UGG--G-CGU------------------------------------------------ -----AGGAAGU-UUGAGUGGAC--CUGACCUUAGUACGAGAGGACCGGGUUGGACUAAC CUC-UGGUGUA-UCUGU-UGUGCCGCCAGGUGC-AG--UGCAGAGUAGCCA-C-GUUGGG ACG-AGAUAAGCGCUGAAAGCAUC--U-AAGCGCGAAACU------CAC-CACAAGA--- --UGAGACU---------------------------UCCAUA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------C---AGGGA---CGUC--A-GAGACUAUGA-CG-UUGAUAGG CUGCA-AGUGUAAA-GUC-A-------------------------GAAA----------- --UGGCA-----UAGCU-----GAGC----A-GUACUAA-UUACCC-------------- -------- >Dechloromonas_aromatica --GAUCAAGC---GA-CUAAGUGCAUGU-GGUGGAUG-CCU-UGGCG-AUC-A--CAGGC GAUGAAGGACGUGCA-AGCCUGCGAAAAGCGGGGGGGAGCUGGCAAUGA-AGCUUU-GAU CCCCCGAUAUCCGAAUGGGGAAACCCACUCAGCAA------------------------- ------------------------------------------------------------ ------------------------------------UGAGUA-------------UCC-C UGACU--------------------------GAAUACAU-A------------------- ---------------GGUCA-GGGAGGCGA-ACCCGGUGAACUGAAACAUCUAAGUAGCC --GGAGGAAAAGAAAUCAA-CCGAGAUUCCCCAAGU-AGU-GGCGAGCGAACGGGG-AUG AGCCUGC--UAGUGA-----------------------------UAGCG----------- ------------------------------------------------------------ -------------------G-------A-----AUGGUUAA------UGG-AACG--GAA UG-GA-------AAGUC------C-GGCC-GUAGUGGGUGAUAGCCCCGUACAUGAAAAC -C-AAU-CC---------G-U----GGUACUAAGUUAGCGAAAAGUAGGGCGGGGCACGU GAAACCUUGUCUGAACAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCG-UG-AUCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAACCUGAAACCGCAUGCAUA-CAA-ACAGU-GGGAGCCU-C----------CU U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G----UGG--------GGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-G----UUUAGUAGCAA---GCUUAA-CCG--------------AAU----- ---------AGG-G-G-A-GGCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AUA--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AUU------------------ ------------------------UAGUUGCUAGGCGUA-GACCCGAAACCGG-AUGAUC UAUCCAUGGCCAGGAUGAAGGUGCC-GUAACAG-GUACUGGAGGUCCGA--ACCC-ACUA -AUGUUGAAAAAUUAGGGGAUGAGCUGUGGAUAGGGGUGAAAGGCUAAACAAAUCCGG-A AAUAGCUGGUUCUCCCCGAAAACUAUUUAGGUAGUGCGUCUUG-U--------------- ------------------------------------------------------------ ---------------------AUC-AC-UGACGGGGGUAAAGC-ACUGUUAUGG--CU-A GG--G-GGU-C-AUCGC-GACUUA-CCAAACCAUGGCAAACUCUGAAUACCGU-CAA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------CG--AG--C-AAGGC-AGA-CAG-ACA--GU-GGGUGCUAACGUCCAU-UG -UCAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--CAAGAC--A U-G-GU-U-AAG--UGGGA-----------AACGAAGUGGGAAGGCAUAGACAGCUAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCUC-A-AACCA---UGC--------ACC--G AAG-CUGCGGA--UAU------C------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- ----------------------------------G-A-U---AU-GG--UAGGG----GA ---G-CGUU-CUGUAGG-------------------UC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUG-U--C-UUGU-AA-AGG--AUGC-U-GGA-GAUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--UAA-AGGGA-G------------------UGAAAAG----- ----------CUCCCU-CGCC-GAA-AGCCC-AAGGUUUCCU-ACGCAACGUUCAUCGGC GUAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCAGAA--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U CAA----UAUU-CCU----GUACC-G-AU-U--CUAG-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-UGG-GG-AC--GGAG-A AGGUUA--GG--U-CA-GC-C-AAC--UGU---UGGA----AUA---GU-UGG-U-UU-- -A------AGC------GU-G------U------A---G----G---C-----G----UG C-C------C---CU-UA-G--G-----C--AAA-U-CCG-GGGGG-CU------UA--G -CU-G--A-GG-C--G--U-G--A-UG-A-CGA--GG-CAC------------------- ---------UA-CG--------------------------------GU-GCU--GAA--G UG-A----UU-GAUAC-CAAG---CUUC-CAGGAAA-A-G-CCAC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UC-U-AGA--AU-U-GACCGUACCGCAAACCGACACAGGUGGGCA-GGA-UGAAAA -U-UCUAAGG-CG-CU-UGAG-AGAACUCA-GGAGAAGGAACUCGGCAAAU-UAACACCG UAACUUCGGG-AGAAGGUGUGC-CC-CG-GU-AG-GUUGUAG-AG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UC-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCU-C-G----- A-----AGG-C-C--G-AUGGG-GUUGCAGUGAAAUGGUGGCUGCGA-----CUGUUUAA UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAUGGGGU----------GCA A------------GCCCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCU-CC-UGA-GACUCAGCGAAGUUGAAAU-GUUUGUGAA GAUGCAAUCUCCCCGCGGCAAGACGGAAAGA-CCCCAUGAACC-UUUACUGUAGCUUUGC AUUGGACUUUGAAUCGGUCUGUGUAGGAU-AGGUGGGAG-GC-UG-U-GAA--ACC--GG GAC--------------------------------------------------------- ----------------------------------GCUA--GUUUC--GGUGGAGC--CA- ACCU-UGAAAUA-CCACCCUGAUUUA-UUUGAGGUUCUAA-CCUUG--AU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUC-GGGGA -CCG-UGCAUGGUGGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAAGGUAAC-GGAGG AGUACGAAGGUACGCUUAGGGCGGUCGGACAUCGCCCAUA-AAGUGC-AAUGGCAAAA-G CGUGCUUGACUG-CGAGACCC-A----CAAGUCGAGCAGGUGCGAAAGCAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCUCAUCCUGGGGCUGUAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGAGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGC------------------------------------------------ -----UGGAAAU-UUGAAGGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUA-CCGGU-UAUGACGCCAGUCGU-AU--CGCCGGGUAGCUA-U-GUUCGG AAG-AGAUAAACGCUGAAAGCAUC--U-AAGCGUGAAACU------CGC-CUUAAGA--- --UAAGAUU---------------------------UC--CC---------GG-A--G-- U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUUGA---------------------------- --------A-CUCC-UUGA---AGGGU---CGUC--G-AAGACCACGA-CG-UUGAUAGG UCAGG-UGUGGAAG-CGC-A-------------------------GUAA----------- --UGCGU--U--AAGCU-----AACU----G-AUACUAA-UUGCCC-GU--ACGG-CUUG -AUCCU-- >Dehalococcoides_ethenogenes --GGUCAAGC---A-GGUAAGGGCACAU-GGUGGAUG-CCU-UGGUA-UCA-A--GAGCC GAUGAAGGACGUGG--UAACUGCGAUAAGCCUCGGUCAGCUGUAAC--A-AGC---UUAG CCGGGGAUUUCCGAAUGGGGCAACCCGCUCAG-G-CA----------------------- ---------------AA------------------------------------------- ---------------------------------ACCUGGGUA-------------CUU-C CAGCU--------------------------CAACACAU-A------------------- ---------------GGCUGGGUAGAGGUA-AGUGGGGGAAGUGAAACAUCUCAGUACCC --CGAGGAAAAGAAA--------UUAUUCUCCUAGU-AGC-GGCGAGCGAACGGGGA-UG AGCCCAAA-CAAGCCUGGU-UGA-AAGAAA-U-------------------C-------- --------------------------UGUGGCAGAG------------------------ -------------------C--------A---AAAGAAGAC------CUG-AAGGU-CCC UG-GA-------ACGGG------C-AACC-ACAGAGGGUGAGAGUCCCGUAAAUUAAAGG -G-UGU-AG---------GCU----UCUGAU---UCUUUCUUGAGUACCACGAGACUCGU GGAAUCUCGUGGGAAUCCGCCGUGACCA--CAUGGCAAGGCUAAAUACUC--UU-GAUGA CCGAUAGU-GAACU-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-AGAGGGGAGU GAAAUAGAACU-GAAACCGUGUGCCUA-CAA-GCAGU-CAGAGGACGU-----------A AG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------C-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCUGAUGGCGUGACUAUUGAAGAAUUAUCCGA CGAGUUAC-------UCA-GUGCAG---GGUUAA-GCA------------UUAAGU---- ---------UGC-G-C-A-GCCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------UUU------------------ ------------------------UAGU-UGUACU-GUA-GACCCGAAGCCGG-GUGAUC UAUCCAUGGCCAGGGUGAAGUGAAG-GUAAUAC-UUCGCGGAGGCCCGA--ACCA-GUCA -ACGUGGCAAAGUUGUUGGAUGAGCUGUGGAUAGCGGUUAUAUGCCAAACGAACCCGG-G GAUAGCUGGUUCUCCUCGAAAU-GCUUUAGG---AGCCUCAGG-C--------------- ------------------------------------------------------------ --------------------GUUC-AU-UAAUGGAGGUAGUGC-ACUGGAUAGA--CU-A GG--G-GGA-G-AGAUC-CUGU---C--AACUCUAACAAACAUCGAAUGCCAUUAA--U- C-A--------------------------------------------------------- ------------------------------------------------------------ ----------A--AG--C-CUGGG-AGU-GAG-ACU--AU-GGGGGCUAAGCUCCAU-AG -UCAAAA-GGGAA----ACA--GCCCAGACCAUC-AGCUAAG--GUCCC--UAAGCG--C A-G-GC-U-AAG--UGGGA-----------AAGGAAGUAGCAUUGCCUAGACAUCCAGUA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAGUGCGUAAUAGCUCACUGGUU-----G AGUGGUGUUGCGCCGACAAUCCAACGGGGCU--U-AAC-U---GUC--------ACC--G AAG-CUAUGGA---UC---U--A----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUAU----------------------------- ---------------------------------GG-U-A-G-AU-GG--UAGAG----GA ---G-CGUU-CCCUC-G-------------------GC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGCAG-G--A-GUGU-AA-ACA--ACUG-U-GGA-GC--UU-AGGGAAGUGAGAAUGU-C GGAAU-GAGUA-GCG-C---AA-GGCGU-G------------------UGAGAAA----- ----------CACGCC-CACC-GUA-AACCU-AAGGUUUCCU-ACGCAAGGUUAAUCCGC GUAGGG------------UUAGUCGG-AC-C-UAA----GCCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGAC-AGC-AGG--U UAU----UAUU-CCU----GCACC-A-CC-G-------U-U------------------- ----------------------------------------------------G-UG-GAG -GA--------------------------------------------------------- -----------------------------------------G-GGG-GG-AC--ACAG-G AGGAUA--GA--UCAG-GC-A--UG--CAU---UGG-----ACAU--C--GUG-U-CG-- -C------UGA------AC-C-C----U------A---G----A---C----------UU U-C------A---AA-UA-G--G-----C--AAA-U-CCG-UUUGG-AG----UUAAG-U -UG-A--A-GU-U--G--U-G--A-AG-G-UGC--GG-GAG------------------- ---------AU-CCA----------------------------------AGC--CAA--U CU-G----GUUGAGUC-CAAG---CUGU-CGAGAAA-A-G-CCUC---U--A-CUG---- -U---------------------------------------------------------- -G--AA-G-AAU--GG-U-GACCGUACCGCAAACCGACACUGGUAGGUG-GGG-GUAAAU -U-CCCAAGG-UG-AU-CGAG-AUAACCCU-CGUUAAGGAACUCGGCAAUC-UAGCCCCG UAACUUCGGG-AGAAGGGGUGC--C-CU--C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GAGG-GUUACAAUAAAGUGGCUCGAGUGA-----CUGUUUAA CAAAGACACAGGUCUCUGC-AAAAGC--GA---A-A------------GCUGAA-GU-AU AGGGGCUG-ACACCUGCCCAGUGC-U-GGAAGGUUAAGGGGAGGAGUU-AGG-----GCA A------CCA-AAGCUCUGAACCGAAGCCCCA-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUCCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGUAUAACA AC-U--UGAGC--GCUGUCUUAA-CG-AGG-GACUCGGUGAAAUUGAAUU-ACCCGUGAA GAUGCGGGUUUCCCGCGACUGGACAAAAAGA-CCCCGUGGAGC-UUUACUAUAACUUGCC AUUGAGUCUGGGUUCAUCAUGUGUAGGAU-AGGUGGGAG-GC-U--GAGAA--GCC--AG GGC--------------------------------------------------------- ----------------------------------GCUA--GCCUU--GGUGGAGC--CA- ACGU-UGAAAUA-CCACUCUUGAUGG-AUCUAGCCUCUAA-CUCUA--GA--------AC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-GCUA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GA-G--------GA -CAG-UGGCUGGUGGAUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAUUGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGGGUGGAUGGAAAUCACCCUAA-GAGUGC-AUUGGCAUAA-G GGAGCUUGACUG-CGAGACAU-A----CAAGUCGAGCAGGGACGAAAGUCGGGCAA-AGU G-AUCCUACG-------------------------G---------CACUG--AGU-GGA- -----------------------------AGGGCCGUGGCUUAUCGGAUAAAAGCUACCC CGGGGA-UAACAGGCUUAUCUUGCCCAAGAGUUCACAUCGACGGCAAGGUUUGGCACCUC UAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGUAGGUCCCAAGGGUCCGGCUGUUCGCCGG UUAAAGCGGCACGCGAGCUGGGUUCAGACCGUCGUGAGACAGGUCGGUCUCUAUCCGUCG --UGG--G-CGU------------------------------------------------ -----UGGAGAU-UUGAGAGGGU--CUUUCCAUAGUACGAGAGGACCUGGAAGGACAGAC CAA-UGGUGUG-UCAGU-UGUUCUGCCAAGGGC-AU--UGCUGAGUAGCCA-A-GUCUGG UUU-GGAUAAGCGCUGAAAGCAUC--U-AAGUGCGAAGCC------GGC-CUCAAGA--- --UUAGAUC---------------------------UC--CCA--------U--C--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CCAA----------------------------- ----------GGGG---GU--AAGACC---GCAG--G-UAGACUACCU-GC-UUGAUAGG -CUGU-G-UGUAAG-UAC-G-------------------------GUAA----------- --CGUAU--U--AAGCU-------CA----G--UACUAA-UGG-UC-GA---GGG-CUUG -ACC---- >Deinococcus_radiodurans --GGUCAAGA---U-AGUAAGGGUCCAC-GGUGGAUG-CCC-UGGCG-CUG----GAGCC GAUGAAGGACGCGAU-UACCUGCGAAAAGCCCCGACGAGCUGGAGA-UA-CGCUU-UGAC UCGGGGAUGUCCGAAUGGGGAAACCCACCUCG---UA----------------------- ---------------AG------------------------------------------- ----------------------------------A---GGUA-------------UCC-G CA-------------------------------A-------------------------- ----------------------GGAUGGGA-ACUCAGGGAACUGAAACAUCUCAGUACCU --GAAGGAGAAGAAAGAGA-AUUCGAUUCCGUUAGU-AGC-GGCGAGCGAACCCGGA-UC AGCCCAAA-CCGAAAC--GC-----------UU-----------G---CGUUUCGGGG-- -------------------------UUGUAGGACCAGUUU-------------------- ----UUAAGAUUCA--------------A---CCCCUCAAG------CCG-AAGU--GGC UG-GA-------AAGCU------A-CACC-UCAGAAGGUGAGAGUCCUGUAGGCGAACGA -G-CGG-UU---------G-A----CUGUAC---UGGCACCUGAGUAGGUCGUUGUUCGU GAAACGAUGACUGAAUCCGCGCGGACCA--CCGCGCAAGGCUAAAUACUC--CC-AGUGA CCGAUAGC-GCA-U-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCG-GGAGGGGAGU GAAAGAGAACCUGAAACCGUGGACUUA-CAA-GCAGU-CAUGGCACCU----------U- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AUC------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------G--UGUUAUGGCGUGCCUAUUGAAGCAUGAGCCGG CGACUUAGAC----CUGACGUGCGA---GCUUAA-GUU-------------GAAAA---- ---------A-C-G-G-A-GGCGGAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAU--------------- -------------------------------------------A-GGGCGG--------- ---------------------------------------CAU------------------ ------------------------UAGUACGUCGGGCUA-GACUCGAAACCAG-GUGAGC UAAGCAUGACCAGGUUGAAACCCCC-GUGACAG-GGGGCGGAGGACCGA--ACCG-GUGC -CUGCUGAAANAGUCUCGGAUGAGUUGUGUUUAGGAGUGAAAAGCUAACCGAACCUGG-A GAUAGCUAGUUCUCCCCGAAAUGUAUUGAGGUACAGCCUCG-G-A--------------- ------------------------------------------------------------ -------------------UGUUG-AC-CAUGUCCUGUAGAGC-ACUCACAAGG--CU-A GG--G-GGC---CUACCA-GCUUA-CCAAACCUUAUGAAACUCCGAAGGGGCA-CGC-G- U-U--------------------------------------------------------- ------------------------------------------------------------ --------UAG--UC--C---GGG-AGU-GAG-GCU--GC-GAGAGCUAACUUCCGU-AG -CCGAGA-GGGAA----ACA--ACCCAGACCAUC-AGCUAAG--GUCCC--UAAAUG--A U-C-GC-U-CAG--UGGUU-----------AAGGAUGUGUCGUCGCAUAGACAGCCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUCAAAGAGUGCGUAAUAGCUCACUGGUC-----G AGUGACGAUGCGCCGAANAUGAU-CGGGGCUC-A-AGUGA---UCU--------ACC--G AAG-CUAUGGA--UUC---A--A----CU-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------G-CGA---------------------------- ---------------AG----C---------GAGU-U-G-U-CU-GG--UAGGG----GA ---G-CGUU-CAGUC-C-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GAGA AGCCA-U--A-CCGG-AA-GGA--GUGG-U-GGA-GCCGAC-U--GAAGUGCGGAUGC-C GGCAU-GAGUA-ACG-A--UAA-AAGAA-G------------------UGAGAAU----- ----------CUUCUU-CGCC-GUA-AGGAC-AAGGGUUCCU-GGGGAAGGGUCGUCCGC CCAGGG------------AAAGUCGGGAC-C-UAA----GGUG-A-GGCCGAA--CGGCG ---------------------------C-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--U-GGAC-AGC-AGG--U CAA----GAUU-CCU----GCACC-G-AU-CA--UGU-G-G------------------- -----------------------------------------------------------A GUG--------------------------------------------------------- ---------------------------------------AUG-GAG-GG-AC--GCAU-U ACGCUA--UC--C-AAUGC-C-AAG--CUA---UGGC----UAU---GC-UGG-UUGG-- -U-------AC------GC-U------C------AA--G----G---G-----C----GA U-C-----GG---GU-CA-G--A--------AAA---UCU-ACCGG-UC-----ACAUGC -CU-C--A-GA-C--G--U----A-UC-G-GGA--GC-UUCC------------------ ----------U-C-G-------------------------------GA-AGC--GAA--G UU-G----GA-AACGC-GACG---GUGC-CAAGAAA-A-G-CUUC---U--A-AAC-GU- UG-A-------------------------------------------------------- ----AA-C-AUG--AU-U-GCCCGUACCGCAAACCGACACAGGUGUCCG-AGUGUCAAU- -GCACUAAGG-CG-CG-CGAG-AGAACCCU-CGUUAAGGAACUUUGCAAUC-UCACCCCG UAACUUCGGA-AGAAGGGGUCC-CC-AC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GC UUCGC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GUGG-GGCGCAGUGAAUAGGCCCAGGCGA-----CUGUUUAC CAAAAUCACAGCACUCUGC-CAACAC--GA---ACA------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUCAAGUGGAGCGGU----------GCA A------------GCUGCGAAAUGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAAGGCGUAACG AU-C--UGGGC--GCUGUCUCAA-CG-AGG-GACUCGGUGAAAUUGAAUU-GGCUGUAAA GAUGCGGCCUACCCGUAGCAGGACGAAAAGA-CCCCGUGGAGC-UUUACUAUAGUCUGGC AUUGGGAUUCGGGUUUCUCUGCGUAGGAU-AGGUGGGAG-CC-U--GCGAA--ACU--GG CCU--------------------------------------------------------- ----------------------------------UUUG--GGGUC--GGUGGAGG--CA- ACGG-UGAAAUA-CCACCCUGAGAAA-CUUGGAUUUCUAA-CCU-G--AA---------- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AAUCAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------U----UUC-GGGGA -CCG-UGCUUGGCGGGUAGUUUGACUGGGGCGGU-CGCCUCCCA-AAAUGUAAC-GGAGG CGCCCAAAGGUCACCUCAAGACGGUUGGAAAUCGUCUGUA-GAGCGC-AAAGGUAGAA-G GUGGCUUGACUG-CGAGACUG-A----CACGUCGAGCAGGGAGGAAACUCGGGCUU-AGU G-AACCGGUG-------------------------G---------UACCG--UGU-GGA- -----------------------------AGGGCCAUCGAUCAACGGAUAAAAGUUACCC CGGGGA-UAACAGGCUGAUCUCCCCCGAGAGUCCAUAUCGGCGGGGAGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGAAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCUCUAUCCGCUA --CGG--G-CGC------------------------------------------------ -----AGGAGAA-UUGAGGGGAG--UUGCUCCUAGUACGAGAGGACCGGAGUGAACGGAC CGC-UGGUCUC-CCUGC-UGUCGUACCAACGGC-ACA-UGCAGGGUAGCUA-U-GUCCGG AAC-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------AGC-CCCAAGA--- --UGAGUUC---------------------------UC--CCA--------CU-G--U-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- ----------UCAG---GU--AAGACU---CCCG--G-AAGACCACCG-GG-UUANGAGG CCAGG-CGUGCACG-CAU-A-------------------------GCAA----------- --UGUGU--U--CAGCG-----GACU----G-GUGCUCA-UCAGUC-GA---GGU-CUUG -ACCAC-- >Escherichia_coli --GGUUAAGC---GA-CUAAGCGUACAC-GGUGGAUG-CCC-UGGCA-GUC-A--GAGGC GAUGAAGGACGUGCU-AAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAA-CCGUUA-UAA CCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUU------------------CG----- ---------------AC------------------------------------------- -----------------------------------AC-ACUA-------------UCA-U UAACU--------------------------GAAUCCAU-A------------------- ---------------GGUUA-AUGAGGCGA-ACCGGGGGAACUGAAACAUCUAAGUACCC --CGAGGAAAAGAAAUCAA-CCGAGAUUCCCCCAGU-AGC-GGCGAGCGAACGGGG-AGC AGCCCA-G-AGCCUGA-AU-------------------------CAGUG----------- ------------------------------------------------------------ -------------------U-------G-----UGUGUUAG------UGG-AAGC--GUC UG-GA-------AAGGC------G-CGCG-AUACAGGGUGACAGCCCCGUACACAAAAAU ---GCA-CA---------U-------GCUGUG-AGCUC-GAUGAGUAGGGCGGGACACGU GGUAUCCUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGGCGAGGGGAGU GAAAAAGAACCUGAAACCGUGUACGUA-CAA-GCAGU-GGGAGCACGC----------UU A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGCG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUCUGUAGCAA---GGUUAA-CCG--------------AAU----- ---------AGG-G-G-A-GCCGAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAC--------------- -------------------------------------------U-GGGCG---------- ----------------------------------------UU------------------ ------------------------AAGUUGCAGGGUAUA-GACCCGAAACCCG-GUGAUC UAGCCAUGGGCAGGUUGAAGGUUGG-GUAACAC-UAACUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGG-A GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUG-A--------------- ------------------------------------------------------------ --------------------AUUC-AU-CUCCGGGGGUAGAGC-ACUGUUUCGG--CA-A GG--G-GGU-C-AUCCC-GACUUA-CCAACCCGAUGCAAACUGCGAAUACCGG-AGA-A- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------UU--AU--C-ACGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--AAAGUC--A U-G-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCCCAGACAGCCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCU--A-AACCA---UGC--------ACC--G AAG-CUGCGGC--AGC---G--A----CG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAU----------------------------- -------------------------------GCGU-U-G-U-UG-GG--UAGGG----GA ---G-CGUU-CUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGUG-U--G-CUGU-GA-GGC--AUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-AAGUA-ACG-A--UAA-AGCGG-G------------------UGAAAAG----- ----------CCCGCU-CGCC-GGA-AGACC-AAGGGUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UGAGUCGACCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-U-GG-U--GUUA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------AG-GGG-GG-AC--GGAG-A AGGCUA--UG--U-UG-GC-C-GGG--CGA---CGG-----UUGU--CC-CGG-U-UU-- -A------AGC------GU-G------U------A---G----G---C-----U----GG U-U------U---UC-CA-G--G-----C--AAA-U-CCG-GAAAA-UC------AAG-G -CU-G--A-GG-C--G--U-G--A-UG-A-CGA--GG-CAC------------------- ---------UA-CG--------------------------------GU-GCU--GAA--G CA-A----CA-AAUGC-CCUG---CUUC-CAGGAAA-A-G-CCUC---U--A-AGC-AU- CA---------------------------------------------------------- -G--GU-A-ACA--UC-A-AAUCGUACCCCAAACCGACACAGGUGGUCA-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UGGUGCCG UAACUUCGGG-AGAAGGCACGC-UG-AU-AUGUA-GGUGAGG-UC-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UC-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGA-U-G----- G-----AGC-U-G--A-AAUCA-GUCGAAGAUACCAGCUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUGUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU ACGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAUGGGGUU-AGC-----GCA A------GCG-AAGCUCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAG--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAACU-CGCUGUGAA GAUGCAGUGUACCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGAC ACUGAACAUUGAGCCUUGAUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GUG--UG GAC--------------------------------------------------------- ----------------------------------GCCA--GUCUG--CAUGGAGC--CG- ACCU-UGAAAUA-CCACCCUUUAAUG-UUUGAUGUUCUAA-CGUUG--AC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUU-GCGGA -CAG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCUA-AAGAGUAAC-GGAGG AGCACGAAGGUUGGCUAAUCCUGGUCGGACAUCAGGAGGU-UAGUGC-AAUGGCAUAA-G CCAGCUUGACUG-CGAGCGUG-A----CGGCGCGAGCAGGUGCGAAAGCAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGUAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGC------------------------------------------------ -----UGGAGAA-CUGAGGGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGCAU CAC-UGGUGUU-CGGGU-UGUCAUGCCAAUGGC-AC--UGCCCGGUAGCUA-A-AUGCGG AAG-AGAUAAGUGCUGAAAGCAUC--U-AAGCACGAAACU------UGC-CCCGAGA--- --UGAGUUC---------------------------UC--CCU--------GA-C--U-- C--C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUG----------------------------- -------AG-AGUC-CUGA---AGGAA---CGUU--G-AAGACGACGA-CG-UUGAUAGG CCGGG-UGUGUAAG-CGC-A-------------------------GCGA----------- --UGCGU--U--GAGCU-----AACC----G-GUACUAA-UGAACC-GU--GAGG-CUUA -ACCUU-- >Fusobacterium_nucleatum ---GUUAAAA---UAAUUAAGGGCACAC-AAAGGAUG-CCU-AGGUA-GUA-A--GAGCC GAUGAAGGACGUGGU-AAGCUGCGAUAAGCCUAGAUAAGUUGCAAU-CG-AACGUAAGAG UCUAGGAUUUCCGAAUGGAGCAAUCUAUUAAGAUGGA----------------------- ---------------G-------------------------------------------- -------------------------------------------------------UCU-- -------------------------------UAAUACGA--------------------- ---------------------AAGAGG-GA-ACCGCGUGAACUGAAACAUCUAAGUAACG --CGAGGAAAAGAAAGUAA-AAACGAUACCCAAAGU-AGC-GGCGAGCGAACUGGGU-CA AGCCUAAA-CCUUAAAUAUGUCA-AGGAUA--CAGCCG------UUGUAUUUAAGGGG-- -------------------------UAGAGGGACAAAGUAGUG-----------AAGAAC UG--UAAGAUAUU-CA-AUA--------U---AGUGUAUUGAUGAAUUAG-AAUU--GUC UG-GA-------AAGAU------G-AACC-GCAGAAGGUGAAAGUCCUGUAUAAGUAAAU -C-CUU-AC---------ACA------UAUAACUUUGCUCCCAAGUAACAUGGAACACGA GGAAUUCUGUGUGAAUCAGUGAGGACCAAAUCUCAUAAGGCUAAAUACUC--UU-ACUAA CCGAUAGC-GCA-U-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCU-GGAGGGGAGU GAAAUAGAACCUGAAAUUGUGUGCUUA-CAA-GCGGU-CAGAGCCCAU----------U- -U---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUGGCGUGCCUUUUGGAGAAUGAUCCUG CGAGUUAC-G----UUAAACGGCGA---GGUUAA-G---------------UAUAA---- -----------C-G-G-A-GCCGAAGGGAAA-CCA------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------A-AU----------------- ------------------------UAGUCGUUUGGCGUA-GACGCGAAACCUG-GUGAUC UAAACCUGUCCAGGAUGAAGCUGUGGU-AAGAC-ACAGUGGAGGUCCUA--ACCC-ACCG -CCGUUGAAAAGUUGGGGGAUGAGGUAGGUUUAGGGGUGAAAAGCCAAUCGAACCAGG-A GAUAGCUCGUUCUCUCCGAAAUGCAUCUAGGUGCAGCCUUGAG-U--------------- ------------------------------------------------------------ --------------------GUUC-AA-UUAUGGGGGUAGAGC-ACUGAAUGAU--CU-A GG--G-GGC---AUAUU--GCUUA-CUGAAAUCAAUCAAACUCCGAAUACCAU-AA--U- U-U--------------------------------------------------------- ------------------------------------------------------------ ---------AU--AG--C-UCAGG-AGU-GAG-ACU--AU-GGGAGUUAACUUCCAU-UG -UCAAAA-GGGAA----ACA--ACCCAGACCACC-AGCUAAG--GUCCC--UAAU-U--A U-A-AC-U-AAG--UGGGA-----------AAGGAGGUGGAGAUUCACAAACAACUAGGA GGUUGGCUUAG-AAGCAGCCAUACCUUUAAAGAGUGCGUAAUAGCUCACUAGUC-----G AGAGUCUCUGCGCCGACAAUGUAACGGGGCU--A-AGUUA---UAA--------ACC--G AAG-CUGUGGA--AUC---C---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUU----------------------------- ------------------------------------G-G-A-UU-GG--UAGGA----GA ---G-CGUU-CUGUAGG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGAAG-A--A-GGGU-AA-CCG--ACUU-U-GGA-GGUAUC-A--GAAGUGAGAAUGC-A GGAAU-AAGUA-GCG-A--GAA-AGGGG-G------------------CGAGAAU----- ----------CCUCCU-CGCC-GGA-AGACC-AAGGUUUUCA-GGGUAAAGCUUGUCUUC CCUGAG------------UAAGCCGGGAC-C-UAA----GCCC-A-GGCUAUA--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA-AU-GGAA-AAC-AGA--U UAA----UAUU-UCU----GUGCC-A-GU-C--AUGU-A-U------------------- ----------------------------------------------------------UG UGA--------------------------------------------------------- ----------------------------------------UG-GAG-GG-AC--GCAG-A AGGGUA--UG--C-GC-GC-G-GAC--GAA---CGGA----AGU---GU-CCG-U-AG-- -A------AGU------AU-G------U------A---G----G---G-----U----GA C-U------U---AG-UA-G--G-----U--AAA-U-CCA-UUAAG-UU------AAA-U -CU-G--A-GG-U--A--U-G--A-UA-U-ACA--GU-C--------------------- ---------GU-AA-----------------------------------GAU--GAA--U GC-G----CA-AAUCC-CACG---CUGC-CAAGAAA-A-G-CUUC---U--A-ACG-UU- -A---------------------------------------------------------- -A--UA-U-AUG--AC-U-GCCCGUACUGUAAACCGACACAGGUGGUCA-GGA-UGAGAA -A-UCUAAGG-CG-GA-CAGG-CUAACUCU-CGUUAAGGAACUCUGCAAAA-UAACCUCG UAACUUCGGG-AGAAGAGGAGC-CC-UU--G-UG-UGU-GAG-UA-UA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C AC-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------G---AUA-C-A----- A-----AGC-G-C--A-CGAGG-GUCGCAGUGAAGAGGCUCAAGCAA-----CUGUUUAA CAAAAACACAGGUCUAUGC-UAAGCU--GU---A-A------------GGCGAU-GU-AU AUGGGCUG-ACACCUGCCCAGUGC-U-GGAAGGUUAAGAGGAGGAGU----------GAG A------------GCUCCGAAUUGAAGCCCCA-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGUGUAAUG AU-U--UGAGC--GCUGUCUUGA-CG-GGA-GGCCUGGUGAAAUUGUAUU-ACCGGUGAA GAUACCGGUUACCUACAGUAGGACGGAAAGA-CCCCAUGGAGC-UUUACUGUAGCUUGGU AUUGGGUUUUGGCAUUGCAUGUAUAGGAU-AGUUGGGAG-AC-UA-U-GAU--GAU--AU GGC--------------------------------------------------------- ----------------------------------GCUA--GCUGU--AUCGGAGU--CA- UCGG-UGGAAUA-CCAACCAUUCAAU-GCUGAAAUUCUAA-UCU-G--UG--------GU U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GU--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------AG-C-CAC-GGAGA -CAG-UGCUAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCGA-AAGAGUAAC-GGAGG CGUUCAAAGGUUCUCUCAGGUUGGAUGGAAAUCAACCAUA-GAGUGC-AAUGGCAUAA-G AGAGCUUGACUG-CAAGACUG-A----CGGGUCGAGCAGAUGCGAAAGCAGGACAU-AGU G-AUCCGGCG-------------------------A---------UUCCG--AAU-GGA- -----------------------------AGGGUCGUCGCUCAACGGAUAAAAGCUACCC UGGGGA-UAACAGGCUGAUCCUACCCGAGAGUCCAUAUCGACGGUAGGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGGAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCACUG --UAG--G-CGU------------------------------------------------ -----UAGAAUA-UUGAGAAGAC--CUGUCCUUAGUACGAGAGGACCGGGAUGGACAAAC CUC-UGAUGUA-CCAGU-UGUCACGCCAGUGGC-AC--AGCUGGGUAGUCA-C-GUUUGG AAU-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------AAC-UUCAAGA--- --UAAGUAU---------------------------UC--UU------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------U--AAGAUA---CCUU--C-GAGCCUAGGA-GG-UUGAUAGG UUGGG-GGUGUAAG-UAC-A-------------------------GCAA----------- --UGUAU--U--UAGCU-----GACC----A-AUACUAA-U-UAUC-GA---AGU-UUUA -AUCUA-- >Geobacillus_kaustophilus --GGUUAAGC---U-GGAAAGGGCGCAC-GGUGGAUG-CCU-UGGCA-CUA-G--GAGCC GAUGAAGGACGGGGC-AAACGCCGAAACGCUUCGGGGAGCUGUAAG-CA-AGCGU-UGAU CCGGAGAUGUCCGAAUGGGGGAACCCACUGUC-CGUA----------------------- ---------------AU------------------------------------------- ---------------------------------GGGGCAGUA-------------UCC-A UGCCU--------------------------GAAUCCAU-A------------------- --------------GGGCAUGGAGGGCACA--CCCGGGGAACUGAAACAUCUUAGUACCC --GGAGGAGAAGAAAGCAA-CCGCGAUUCCCUGAGU-AGC-GGCGAGCGAAACGGGA-AC AGCCCAAA-CCAAGAG--GC-----------AU-----------GU--CCUCUUGGGG-- -------------------------UUGUAGGACCGCUCA-------------------- --CGAUGGGAGUGAGAAAGG--------G---ACGGGGUAG------ACG-AACCG-GUC UG-GA-------ACGGC------C-GGCC-AGAGAAGGUGAGAGCCCUGUAGUCGAAACU -U-CGU-UC---------CCU----CCCGAG---CGGAUCCUGAGUACGGCGGGACACGA GGAAUCCCGUCGGAAGCAGGGAGGACCA--UCUCCCAAGGCUAAAUACUCC-CU-AGUGA CCGAUAGU-GCACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GGAGGGGAGU GAAAGAGAACCUGAAACCGUGUGCCUA-CAA-GUAGU-CAGAGCCCGU----------UG AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUGGCGUGCCUUUUGUAGAAUGAACCGG CGAGUGAC-G----AUGGCGUGCGA---GGUUAA-GCC-------------GAAGA---- ---------GGC-G-G-A-GCCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAC--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------UGU------------------ ------------------------GAGUACGUCGUCGUC-GACCCGAAACCAG-GUGAUC UACCCAUGUCCAGGGUGAAGGCCGG-GUAACAC-CGGCUGGAGGCCCGA--ACCC-ACGC -ACGUUGAAAAGUGCGGGGAUGAGGUGUGGGUAGGGGUGAAAUGCCAAUCGAACUUGG-A GAUAGCUGGUUCUCCCCGAAAUAGCUUUAGGGCUAGCCUCGGG-U--------------- ------------------------------------------------------------ -------------------UUGAG-AG-UCUUGGAGGUAGAGC-ACUGAUUGGG--CU-A GG--G-GCC-C-CAAAC-GGGUUA-CCGAACCCAGUCAAACUCCGAAUGCCAAUGA--C- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UG--C-CCGGG-AGU-CAG-ACC--GC-GAGUGAUAAGAUCCGU-GG -UCGAGA-GGGGA----ACA--GCCCAGACCGCC-AGCUAAG--GCCCC--GAAGUG--C A-C-GU-U-CAG--UGGAA-----------AAGGAUGUGGAGUUGCCGAGACAACCAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAGAGUGCGUAAUAGCUCACUGGUC-----G AGUGACUCUGCGCCGAAAAUGUACCGGGGCU--A-AACGU---GCC--------GCC--G AAG-CUGCGGG--AUG-----------AC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GU-U----------------------------- -------------------------------GGU----C-A-UC-GG--UAGGG----GA ---G-CGUU-CUAAG-G-------------------GC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GAGA AGCCA-G--A-CCGG-AA-GGA--CUGG-U-GGA-GCGCUU-A--GAAGUGAGAAUGC-C GGUAU-GAGUA-GCG-A--AAA-CAGAG-G------------------UGAGAAU----- ----------CCUCUG-CGCC-GAA-AGCCU-AAGGGUUCCU-GAGGAAGGUUCGUCCGC UCAGGG------------UUAGUCGGGAC-C-UAA----GCCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GU---GA--U-GGAC-AAC-AGG--U UGA----GAUU-CCU----GUACC-A-CC-UU-CUUC-C-C------------------- ----------------------------------------------------G-UUUGAG CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GCAG-G AGGAUA--GG--GCGA-GC-A-GGC--GGC---UGGA----AGA---GC-CUG-U-CC-- -A------AGC------CG-U------G------A---G----G---C----------UG A-U------C---CG-CA-G--G-----C--AAA-U-CCG-CGGAU-CA----U-AAG-G -CC-A--A-GC-G--G--U-G--A-CG-G-CGA--CG-GA-------------------- ---------UU-G-A--------------------------------U-CCG--GAA--G UC-C----CC-GAUUU-CACA---CUGC-CAAGAAA-A-G-CCUC---U--A-GCG---- -A---------------------------------------------------------- -G--GG-A-AGA--GG-U-GCCCGUACCGCAAACCGACACAGGUAGGCG-AGG-AGAGAA -U-CCUAAGG-CG-CG-CGGG-AGAACUCU-CGUUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-UC-UU--U-GG-GGU---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AA-GA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GC-C-C--U-GAAGA-GCCGCAGUGAAAAGGCCCAAGCGA-----CUGUUUAU CAAAAACACAGGUCUCUGC-GAAGCC--GA---A-A------------GGCGAC-GU-AU AGGGGCUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGGGGAGCGCUU-AGC-----GGA A------GCG-AAGGUGCGAACCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGUGUAACG AC-U--UGGGC--GCUGUCUCAA-CG-AGA-GACCCGGUGAAAUUAUACU-ACCUGUGAA GAUGCAGGUUACCCGCGACAGGACGGAAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGAU AUGGAAUUUUGGUAUCGCUUGUACAGGAU-AGGUGGGAG-CC-U--GGGAA--GCC--GG AGC--------------------------------------------------------- ----------------------------------GCCA--GCUUC--GGUGGAGG--CG- ACGG-UGGGAUA-CCACCCUGGCGGU-AUUGAAAUUCUAA-CCCGC--AC--------CC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GG-G-GUG-GGAGA -CAG-UGUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCCA-AAAGGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGAAUGGUUGGAAAUCAUUCGGA-GAGUGC-AAAGGCACAA-G GGAGCUUGACUG-CGAGACGG-A----CAGGUCGAGCAGGGACGAAAGUCGGGCUU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGCUACCC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --CGG--G-CGG------------------------------------------------ -----AGGAAAU-UUGAGAGGAG--CUGUCCUUAGUACGAGAGGACCGGGAUGGACGCAC CGC-UGGUGUA-CCAGU-UGUCCCGCCAGGGGC-AC--CGCUGGGUAGCUA-U-GUGCGG ACG-GGAUAAGCGCUGAAAGCAUC--U-AAGCGUGAAGCC------CCC-CUCAAGA--- --UGAGAUU---------------------------UC--CCA--------CC-G--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAAA---------------------------- ----------GCGG---GU--AAGAUC---CCUC--G-AAGAUGACGA-GG-UCGAUAGG UCCGA-GGUGGAAG-CGU-G-------------------------GCGA----------- --CACGU--G--GAGCU-----GACG----G-AUACUAA-UCGAUC-GA---GGG-CUUG -ACCUA-- >Geobacter_sulfurreducens --GGUCAAGC---UA-CUAAGGGCGUAC-GGUGGAUG-CCU-AGGCA-GAG-A--GAGGC GAUGAAGGACGUGGU-AAGCUGCGAAAAGCCUCGGGGAGCCGCUAAACA-GGCUUU-GAU CCGGGGGUGUCCGAAUGGGGAAACCCGGCGGAGGUCAU----------------G----- ---------------CU------------------------------------------- ------------------------------------CCGUCA-------------UCG-U GCACU--------------------------GAAUCCAU-A------------------- ---------------GGUGC-AUGAAGCGA-ACGGGGGGAACUGAAACAUCUAAGUACCC --CCAGGAAAAGAAAACAA-UAGUGAUUCCGUCAGU-AGU-GGCGAGCGAAAGCGG-AAC AGCCCA-A-ACCGAGA-GGACUA---------------------CGGUCCUUUCGGGG-- -------------------------UUGUGGGACCC-CGA-----C--------GUGGG- --AUUG------------AU-------G-----AUGGGUAG------CUA-AACG--GUC UG-GA-------AAGUC------C-GGCC-AUAGUGGGUGAUAGCCCCGUAAGCGAAACC -U-UGA-UU---------C-------ACCCUAGGGGUAUCCCGAGUACCGCGGGACACGU GGAAUCCCGUGGGAAGCUGGGAGGACCA--UCUCCCAAGGCUAAAUACUAC-UC-UCUGA CCGAUAGU-GCACA-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-UCCGAUGAGGAGGGU GAAAUAGAACCUGAAACCGUAUGCCUA-CAA-GCAGU-GGGAGCACUA----------UG UA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAUCAAG----------------UGUGACCGCGUGCCUUUUGCAUAAUGAGUCAG CGAGUUAC-U----CUCGGCAGCGA---GGUUAA-GCU--------------CAUAG--- ---------AGU-G-G-A-GCCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------UUU------------------ ------------------------GAGUUGCCGGGAGUA-GACCCGAAACCGG-GUGAUC UAUCCAUGUCCAGGGUGAAAGGAAG-GUAACAC-UUCGUGGAGGCCCGA--ACCC-ACUG -GCGUUGAAAAGCCAGGGGAUGAGGUGUGGAUAGGAGUGAAAGGCUAAUCAAACUCGG-A GAUAGCUGGUUCUCCCCGAAAUAUAUUUAGGUAUAGCCUCGUG-A--------------- ------------------------------------------------------------ --------------------AGUA-AG-UAGUGGGGGUAGAGC-ACUGAAUGGG--CU-A GG--G-GUC-C-UACC--AGAUUA-CCAAACCCAAUCAAACUCCGAAUACCAC-UAA-C- U-G--------------------------------------------------------- ------------------------------------------------------------ ----------U--UA-UC-ACGGG-AGU-CAG-ACU--GC-GGGUGAUAAGAUCCGU-AG -UCAAAA-GGGAA----AGA--GCCCAGAUCGUC-GGCUAAG--GUCCC--AAAAUC--C A-U-GC-U-AAG--UGGAA-----------AACGAUGUGGAAAUGCCCAGACAACCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUGGGUCUGCGCGGAAAAUGUAACGGGGCUC-A-AGCAU---GGU--------ACC--G AAG-CCACGGG--UUG---A--U----AC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAA----------------------------- -------------------------------GGUA-U-C-A-GC-GG--UAGGG----GA ---G-CAUU-GUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGUC-G--A-CCGC-GA-GGA--CGGC-U-GGA-GGUAUC-A--CAAGAGAUUAUGC-U GACAU-GAGUA-GCG-A--AAA-UGCGG-G------------------UGAGAAA----- ----------CCCGCA-CACC-GAA-AACCC-AAGGGUUCCU-CAGUAAAGGUAAUCUGC UGAGGG------------UUAGUCGGUCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UU---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-A-CU-U--GUCG-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GGAG-A AGGGUA--GG--C-GA-UC-C-GGG--UGC---UGG-----ACGU--CC-CGG-U-UC-- -A------AGC------GU-G------U------A---G----G---C-----G----GG A-A------G---AG-GA-G--G-----C--AAA-U-CCC-UUCUU-CC----AUACAAC GCC-A--A-GG-C--G--U-G--A-UG-A--CG--AG-GGGG------------------ ---------UA-U------------------------------C--CC-CAC--AAA--G UC-G----UU-GAUCC-CAUG---CUUC-CAAGAAA-A-G-CCUC---U--A-AGC-UUC A----------------------------------------------------------- -G--GC-G-GCA--GG-U-GACCGUACCGUAAACCGACUCAGGUGGGUG-AGG-AUUAAU GU-CCUAAGG-UG-CU-UGAG-AGAACACU-GGUUAAGGAACUCGGCAAAU-UGACACCG UAACUUCGGG-AGAAGGUGUGC-CC-UC--A-CUAGGUGUAG-CG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AU UC-GCA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------CG-U-G----- A-----AGC-C-G--A-AGAGG-GUCGCAGAGAAAUGGCGGUAGCGA-----CUGUUUAC UAAAAACACAGGACUCUGC-UAAGUC--GC---A-A------------GACGAU-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGGGGAUUUGUU-AGC-----GCA A------GCG-AAGCUUUGAACCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-U--UCCGC--GCUGUCUCAA-CC-AGU-GGCUCAGCGAAAUUGAAUU-CUCGGUGAA GAUGCCGAGUACCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUACAGCUUGAC AGUGACAUUCGGAAUAGCUUGUGUAGGAU-AGGUGGGAG-GC-UG-U-GAA--ACC--GG GAC--------------------------------------------------------- ----------------------------------GCCA--GUUUC--GGUGGAGC--CA- ACCU-UGAAAUA-CCACCCUGGUUGU-UUUGGAUGUCUAA-CCCAG--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-CAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-GGGGA -CAC-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCCA-AAGCGUAAC-GGAGG CGCGCGAAGGUUCCCUCAGGCUGAUUGGAAACCAGCCGUA-GAGUGC-AAAGGCAUAA-G GGAGCUUGACUG-CGAGACAG-A----CACGUCGAGCAGGUACGAAAGUAGGCCUU-AGU G-AUCCGGCG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGAAGUCGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGCGGUACGCGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGC------------------------------------------------ -----AGGAUAC-UUGAGAAGAG--CUGUCCUUAGUACGAGAGGACCGGGAUGGACGUAC CUC-UAGUGUU-CCAGU-UGUUCCGCCAGGAGC-AUU-CGCUGGGUAGCUA-U-GUACGG AAA-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UCC-UUCAAGA--- --UUAGGUA---------------------------UC--CCC--------GG-G--A-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCGA----------------------------- --------G-UCCC-CU-G--AAGGCC---CGUU--G-UAGACCACAA-CG-UUGAUAGG CCGGG-UGUGUAAG-CAG-G-------------------------GUAA----------- --CCUGC--U--CAGCU-----GACC----G-GUACUAA-UCGGCC-GU--GAGG-CUUG -ACCAU-- >Gloeobacter_violaceus ----UCAAGC---U-ACACAGGGCGUAC-GGUGGAUA-CCU-AGGCA-CAG-U--CAGCC GAUGAAGGACGCGGC-UACCGGCGAAACGCGACGGGGAGCAGGAAG-CA-UGCUU-UGAU CCGUCGGUGUCCGAAUGGGGAAACCCGGCAUC-CUUA----------------------- ------------------------------------------------------------ -------------------------------------------------------ACA-- -------------------------------GGGUGUCG-U---------------C--- ---------------CGCA--AGGACGGGA-ACCAGGCGAAUUGAAACAUCUUAGUAGCC --UGAGGAAAAUAAAGUAA-AAACGAUUCCCUCAGU-AGC-GGCGAGCGAACGGGGA-AG AGCCCAAA-CCGAUGG--G------------UU-----------ACGACCUGUCGGGG-- -------------------------UUGUAGGACAGCUAU-------------------- -----CUGGAGU-------G--------C---GUUUGCUAG------GCG-AAUG--GGU UG-GA-------AAACC------C-GACC-AAAGAAGGUGAUAGUCCUGUACUCGAAAGC -A-AAC-AA---------A-C----CCUGGC---UGAAUCCUGAGUAGCACGGGGCACGU GAAAUCCCGUGUGAAUCUGCGAGGACCA--UCUCGUAAGGCUAAAUACUG--UC-UGUGA CCGAUAGC-GAU-U-AGUACCGCGAGGGAAAGGUGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAACAUGAAACCGUAUGCCUA-CAA-GCAGU-GGGAGCACGA----------UU U-------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACCGCGUGCCUGUUGAAGAAUGAGCCGG CGAGUUAC-G----GUCAGUGGC-A---GGUUAA-GCC--G-----------AAAA---- --------UGGC-G-G-A-GCCAAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------C------------------- ------------------------UAGUCACUGGUCGUA-GACCCGAAGCCUG-GUGAUC UAACCAUGGCCAGGAUGAAGCUUGGGU-AACAC-CAAGUGGAGGUCCGA--ACCG-ACUG -AUGUUGAAAAAUCAGCGGAUGAGCUGUGGUUAGGGGUGAAAUGCCAAUCGAACUAGG-C GAUAGCUGGUUCUCCCCGAAAUGUGUUUAGGCACAGCGUUAGG-U--------------- ------------------------------------------------------------ --------------------GUUU-AU-GGGCGGGGGUAGAGC-ACUGAUUCGG--UG-C GG--G-CUG-C-GAGA--GCGGUA-CCAAAUCGAGCCAAACUCCGAAUACCGU-CCA-A- C-A--------------------------------------------------------- ------------------------------------------------------------ ----------U--AG--C-CUGGC-AGU-GAG-ACU--GU-GGGGGAUAAGCUCCAU-GG -UCGAGA-GGGAA----ACA--GCCCAGACCACC-AACUAAG--GUCCC--CAAAUU--G U-A-GC-U-CAG--UGAUU-----------AAGGAGGUGGGAUUGCACAGACAACCAGGA GGUUGGCCUAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGCGAUCCUGCGCCGAAAAUG-AACGGGGCU--A-AGCUA---CAU--------ACC--G AAG-UUGUGGA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- -------------------------------------------U-GG--UAGGG----GA ---G-CGUU-CCGCAGU-------------------AG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGCGU-C--A-GCGACAA-GCA--GGCG-U-GGA-CGAGGC-G--GAAGUGAGAAUGU-C GGCUU-GAGUA-GCG-C--AAA-CAUUG-G------------------UGAGAAU----- ----------CCAAUG-CUCC-GAA-AGCAC-AAGGUUUCCU-CCGGAAGGUUCGUCCGC GGAGGG------------UUAGCCGGGAC-C-UAA----GGCG-A-AGCCGAA--GGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAU-AAC-AGG--U GUA----UAUU-CCU----GUGCU-G-UG-U--CGCU-G-G------------------- -----------------------------------------------------------A GUGU-------------------------------------------------------- ----------------------------------------CA-AAG-GG-AC--GCAU-G AGGAUA--GG--C-CA--U---------------------------------A-C-CC-- -U-------U-------A------------------------------------------ -----CUGG--------------------------------------------------- ------------A-----U------UG-G-GGA--GC-UCC------------------- ---------UA-CG--------------------------------GG-AGC--AGU--U UG-G----CC-G--AA-AGUA---GUGC-CGAGAAA-A-G-CUUU---G-C-CACA-UU- -G---------------------------------------------------------- -A--AA-G-C-A--CG-C-ACCCGUACCCGAAACCGACACAGGUGUGCA-GGU-AGAGAA -U-ACCAAGG-AG-CG-CGAG-AUAACCCU-CUUUAAGGAACUCGGCAAAA-UAGCCCCG UAACUUCGGA-AGAAGGGGUGC-CC-CC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GGGG-GUCGCAGUGAAAUGGCUCUGGCGA-----CUGUUUAC CAAAAACACAGGUCUCUGC-AAAGCC--GC---A-A------------GGCGAC-GU-AU AGGGGCUG-ACUCCUGCCCAGUGC-C-GGAAGGUUACGGAAGUCGGUU-AGC-----GAA A------GCG-AAGCUGGCGACCUAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAAGGAGUAACG AU-C--AGAGC--GCUGUCUCGA-AG-AGG-GACUCGGCGAAAUAGGAUU-GUCUGUGAA GAUACGGACUACUUGUACCCGGACAGAAAGA-CCCUAUGAAGC-UUUACUCUAGCUUGAA AUUGGGUUCGGGCUUUGUCUGCGCAGGAU-AGGCGGGAG-CC-GG-U-GAU--ACA--UC UCU--------------------------------------------------------- ----------------------------------UGCG--GGGGG--UGUGGAGG--CA- ACGG-UGAGAUA-CCGCUCUGACAGG-GUCUGGAUUCUAA-CC----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-ACG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GGGA -CAG-UUUCAGGUGGGGAGUUUGACUGGGGCGGU-CGCCUCCUA-AACGGUAAC-GGAGG CGCGCAAAGGUUCCCUCAGGCUGGUCGGAAAUCAGCCGCA-GAGUGU-AAAGGCAUAA-G GGAGCUUGACUG-CGAGACCU-A----CAAGUCGAGCAGAGACGAAAGUCGGCCUU-AGU G-AUCCGACG-------------------------G---------UUCUG--CAU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGUUACUC UAGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCGUCGCAACCUGGGGCGGUAGUACGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCAUAUCCGGUA --CAA--G-CGC------------------------------------------------ -----AAGAGUG-UUGAGAGGAG--CUCUCCCUAGUACGAGAGGACCGGGAGGGACUGAC CGC-UGGUGUA-CCUGU-UAUCGUGCCAACGGU-AA-ACGCAGGGUAGCUA-U-GUCGGG -AGUGGAUAACCGCUGAAAGCAUC--U-AAGUGGGAAGCC------CAC-CUCAAGA--- --UGAGCAC---------------------------UC--UCU--------CC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAAG---------------------------- ------------GG----U--AAGACC---ACGG--G-AAGAUUACCC-GU--UAAUAGG CUCUA-GGUGGAAG-CGC-A-------------------------GCAA----------- --UGUGU--G--CAGCC-----GAGG----A-GUACUAA-UAGGUC-GA---GGG-CUUG -ACUU--- >Gluconobacter_oxydans ---------------GAGAAGGGCGUUC-GGUGGAUG-CCU-UGGCA-CUA-A--GAGGC GAUGAAGGACGUGGU-ACGCUGCGAAAAGCCAUGGGGAGCCGCGAA-CA-GGCUUU-GAU CCGUGGAUGUCCGAAUGGGGCAACCCCCUCGCAAGA------------------------ ------------------------------------------------------------ ---------------------------------------GGA-------------UCA-U GCACU--------------------------GAAUACAU-A------------------- ---------------GGU-GUAUGAGGCAA-ACCCGGGGAACUGAAACAUCUCAGUACCU --GGAGGAAAAGACAUCAA-CAGAGAUUCCGCUAGU-AGU-GGCGAGCGAACGCGG-AGC AGGCCAAU-GC-CUG------------------------------AU-C----------- ------------------------------------------------------------ -------------------A-------------GGAAGAAG------CUG-AACG--GUC UG-GA-------AAGUC------C-GGCA-AGAAUGGGUGAUAGCCCCGUAAGCGUAGUG -U-U-C-UG---------A---------UGAG-----GAUUCGAGUAGGGCGGGGCACGU GAAACCCUGUCUGAACAUGGGGGGACCA--CCCUCCAAGCCUAAAUACUCC-UU-AGUGA CCGAUAGC-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGAUGAGGGGAGU GAAAGAGACCU-GAAACCGGACGCCUA-CAA-GCAGU-CGGAGCC-------------UC UU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AUGG--------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGAGUUUC-U----GUUUGCAGCGA---GCUUAA-GCC--------------GUUA---- ---------GGU-G-U-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AAU------------------ ------------------------GAGUUGCUGGCAGAA-GACCCGAAACCGA-GUGAUC UAGCCAUGGCCAGGCUGAAGGUGCG-GUAACAC-GCACUGGAGGGCCGA--ACCC-ACGC -CUGUUGAAAAAGUCGGGGAUGAGCUGUGGCUAGGGGUGAAAGGCCAAUCAAACUCGG-A GAUAGCUGGUUCUCCGCGAAAUCUAUUGAGGUAGAUCGUCGGG-U--------------- ------------------------------------------------------------ --------------------GUUU-AC-CCUGGGGGGUAGAGC-ACUGGAUGGG--CU-A GG--G-GGG-C-CCAAA-GCCUUA-CCAAACCUAACCAAACUCCGAAUACCCA-GGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ----------U--AG--C-CCGGC-AGA-CAG-ACA--GU-GGGUGCUAAGGUCCAU-UG -UCGAGA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GCCCC--UAAAUC--G U-G-GC-U-AAG--UGGGA-----------AAGGAUGUGGGGAUUCCAAAACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAAUAGCUCACUGGUCUAU-U- AGAAACCCUGCGCCGAAAAUGUAACGGGGCUC-A-AGCCA---CGU--------GCC--G AAG-CUGUGGG--UGC---A--U----AC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------U-AU----------------------------- --------------------------------GUA-U-G-C-GC-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------UC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGAG-AC-G-GGGU-GA-CCC--UCUC-U-GGA-GAUAUC-G--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--CAA-ACAGU-G------------------CGAGAAA----- ----------CACUGU-CGCC-GAA-AGUCC-AAGGGUUCCU-GCGCAAGGUUAAUCCAC GCAGGG------------UGAGCCGGCCC-C-UAA----GGCG-A-GGGCGAG--AGCCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-AGU--U CAA----UAUU-ACU----GGGCC-U-GC-C--A-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GA-AGU--G-AC--GAAU-G AGAGAU--GU--U-GU-CU-G-UCC-UUAA---CGG-----AUU---GA-ACA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GC-U----UU----UCAA-UC---AUUC-CAGGAAA-U-A-GCUC---U--G-G------ ------------------------------------------------------------ ---------CGU--AU-A-GACCGUACCCGAAACCGACACAGGUGGACU-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACGAU-GCUGAAGGAACUAGGCAAAU-UGCUCGUG UAACUUCGGG-AUAAACGAGAC-CC-GC-----------UCG-UG-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CCA-U-G----- G-----------------ACGG-GUGGCACAGACCAGGGGGUAGCGA-----CUGUUUAG UAAAAACACAGGGCUCUGC-GAAAUC--GU---G-A------------GAUGAC-GU-AU AGGGCCUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGAGGAGGUGU----------GCA A------------GCACUGAAUUGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--ACUGUCUCCA-GC-AUC-GACUCAGCGAAAUUGAAUU-CCCCGUGAA GAUGCGGGGUACCCGCGGUCAGACGGAAAGA-CCCUAUGAACC-UUUACUGCAGCUUUGC AGUGGCAUCAGAGACAUUCUGUGUAGGAU-AGGUCGGAG-GC-UU-U-GAA--ACC--CA GGC--------------------------------------------------------- ----------------------------------GCCA--GCUUG--GGUGGAGC--CA- UCCU-UGAAAUA-CGACCCUGAAUUU-UUCUGAUGUCUAA-CCGAG--AC--------CA G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CU-G-GUC-CGGGA -CCC-UGCAUGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCCA-AAGUGUAAC-GGAGG CGCGCGAUGGUGGGCUCAGGCCGGUCGGAAACCGGCUGUC-GAGUGC-AAUGGCAUAA-G CCCGCCUGACUG-UGAGAGUG-A----CAGCUCGAUCAGAGACGAAAGUCGGCCAU-AGU G-AUCCGGUG-------------------------G---------UCCCA--UGU-GGA- -----------------------------CGGGCCAUCGCUCAACGGAUAAAAGGUACUC UAGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGUGGUACGUGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----AAGAGAC-UUGAGAGGAU--UUGUCCCUAGUACGAGAGGACCGGGAUGAACAUAC CUC-UGGUGCA-CCGGU-UGUCACGCCAGUGGC-AC--AGCCGGGUAGCUA-A-GUAUGG ACG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACC------CAC-CUCAAAA--- --CGAGGUC---------------------------UC--A------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------UAGAGC---CGUG--A-CAGACCAUCA-CG-UUGAUAGG CCGGG-UGUGAAAG-UGC-A-------------------------GUAA----------- --UGCAU--G--CAGCU-----AACC----G-GUCCUAA-UCG----------------- -------- >Haemophilus_influenzae ----UUAAGU---GA-CUAAGCGUACAA-GGUGGAUG-CCU-UGGCA-AUC-A--GAGGC GAAGAAGGACGUGCU-AAUCUGCGAAAAGCUUGGAUGAGUCGAUAA-GA-GGCGUU-UAA UCCAAGAUAUCCGAAUGGGGAAACCCAGUAGAUGAAGA---------------------- ---------------AU------------------------------------------- ------------------------------------CUACUA-------------UCA-A CAAGU--------------------------GAAUUCAU-A------------------- ---------------GCUUG-UUGAGGCAA-ACCGGGAGAACUGAAACAUCUAAGUACCC --CGAGGAAAAGAAAUCAA-CCGAGAUUUCGUCAGU-AGC-GGCGAGCGAAAGCGA-AAG AGCCAGU--AAGUGA-----------------------------UAGCA----------- ------------------------------------------------------------ -------------------A-------U-----AUAGUGAG------GAG-AAUG--UGU UG-GG-------AAGCA------C-AAUC-AAAGAGGGUGAUAAUCCCGUAUCUAAAAAC -C-AUA-UU---------G-U----GGUACUAAGCUAACGAGAAGUAGGGCGGGACACGU GAUAUCCUGUUUGAAGAAGGGGGGCCCA--UCCUCCAAGGCUAAAUACUCC-UG-AUUGA CCGAUAGU-GAACC-AGUACUGUGAAGGAAAGGCGAAA-AGAAC-CCCGGUGAGGGGAGU GAAAUAGAACCUGAAACCUUGUACGUA-CAA-GCAGU-GGGAGCGAGG----------GC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ACCU-UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUUUGUAGCGA---GGUUAA-CCG--------------AAU----- ---------AGG-G-G-A-GCCGAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAC--------------- -------------------------------------------U-GGGCG---------- ----------------------------------------AA------------------ ------------------------UAGUUGCAAGGUAUA-GACCCGAAACCCG-GUGAUC UAGCCAUGGGCAGGUUGAAGGUUGG-GUAACAC-UAACUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGG-A GAUAGCUGGUUCUCCCCGAAAUCUAUUUAGGUAGAGCCUUGAG-G--------------- ------------------------------------------------------------ --------------------UGAC-AC-CUUUGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGC-C-AUCCC-GGCUUA-CCAACCCGAUGCAAACUACGAAUACCAA-AGA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ -------------AUA-C-UCAGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGGAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--CAAGUC--U A-U-AU-U-AAG--UGGGA-----------AACGAAGUGGGAAGGCUUAGACAGCUAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCUG-A-AAUAU---AGC--------ACC--G AAG-CUGCGGC--AUC------A----GA-A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- -------------------------------UUCU---G-U-UG-GG--UAGGG----GA ---G-CGUU-GUGUAAG-------------------CG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AAGA AGGUU-C--A-UCGA-GA-GGU--GGGC-U-GGA-CGUAUC-A--CAAGUGCGAAUGC-U GACAU-AAGUA-ACG-A--UAA-AACGG-G------------------UGAAAAA----- ----------CCCGUU-CGCC-GGA-AGACC-AAGGGUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UGAGUCGGCUC-C-UAA----GGCG-A-GGCUGAA--AAGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-U-GG-U--AAAG-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-UGG-GG-AC--GGAG-U AGGUUA--GG--U-UA-UC-G-CAC--UGU---UGG-----AUAU--GU-GCG-U-UU-- -A------AGU------UG-G------U------A---G----G---U-----G----GG A-A------G---UU-UA-G--G-----C--AAA-U-CCG-GACUU-CC----UUAAC-A -CA-G--A-GA-G--A--U-G--A-UG-A-CGA--GG-CUC------------------- ---------UA-CG--------------------------------GA-GCU--GAA--G UA-A----CU-GAUAC-CACA---CUUC-CAGGAAA-A-G-CCAC---U--A-AGC-GA- AA---------------------------------------------------------- -G--GC-U-UUA--CU-A-AACCGUACUGAAAACCGACACAGGUGGUCA-GGU-AGAGAA -U-ACUCAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UAGCACCG UAACUUCGGG-AGAAGGUGCGC-CG-GC-GU-AG-AUUGUAA-GG-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UA-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CCC-U-G----- A-----AGG-U-U--G-AACCG-GUCGAAGAUACCAGCUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-AUGCCUGCCCGGUGC-U-GGAAGGUUAAUUGAUGGUGUC-AUC-----GAA A------GAG-AAGCACCUGAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCAUAAUG AU-G--GCCAG--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAAAU-CGCCGUGAA GAUGCGGUGUACCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGAC ACUGAACAUUGAAUUUUGAUGUGUAGGAU-AGGUGGGAG-CC-UU-U-GAA--GCA--GU GAC--------------------------------------------------------- ----------------------------------GCCA--GUCAU--UGUGGAGG--CG- ACCU-UGAAAUA-CCACCCUUUAACG-UUUGAUGUUCUAA-CGAAG--AU--------GA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------C-GAAA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CGUG-GUC-UCGGA -CAG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGCGUAAC-GGAGG AGCACGAAGGUUUGCUAAUCACGGUCGGACAUCGUGAGGU-UAGUGC-AAUGGUAUAA-G CAAGCUUAACUG-CGAGACAG-A----CAAGUCGAGCAGGUACGAAAGUAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGUAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----AGGAUGA-UUGAUUGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGCAU CAC-UGGUGUU-CCGGU-UGUGUCGCCAGACGC-AU--UGCCGGGUAGCUA-A-AUGCGG AAG-AGAUAAGUGCUGAAAGCAUC--U-AAGCACGAAACU------UGC-CAAGAGA--- --UGAGUCA---------------------------UC--CCU-----------G--A-- C--U-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- -------AG-UC---AGUA---AGGGU---UGUU--G-UAGACUACGA-CG-UAGAUAGG UUGGG-UGUGUAAG-UGA-U-------------------------GUGA----------- --GUCAU--U--GAGCU-----AACC----A-AUACUAA-UUGCCC-GA--GAGG-CUUA -ACU---- >Helicobacter_hepaticus ----AAAAGC---UU-UUAAGGGCAGAU-GGUGGAUG-CCU-UGGGU-GAU-A--GAGGC GAUGAAGGACGUACU-AGACUGCGAUAAGCUAUGGAGAGCUGUCAA-GA-AGCUUU-GAC CCAUAGAUUUCCGAAUGGGGCAACCCAAUACCUAGAGA---------------------- ------------------------------------------------------------ ------------------------------------UAGGUA-------------UUA-- ------------------------------------------------------------ ---------------CCUUUAAUGGAGCGA-ACCUAGCGAAGUGAAACAUCUCAGUAGCU --AGAGGAAAAGAAAUCAA-ACGAGAUUCUCCUAGU-AGC-GGCGAGCGAACGGGG-AAG AGGGCAA--AC-CAG------UA---------------------GCUUGCUACUGGGG-- -------------------------UUG-AGGACUG-CAA-----U--------AUCCA- --CUUG------------AA-------------UAAUUGAG------CAG-AAGU--AUU UG-GA-------AAAAU------A-CAUC-ACAGAGGGUGAUAAUCCCGUAUGCGAAGGU -U-A-U-UC---------A-U----A--GGUAGCAGUAUCCAGAGUAGGUCAGGGCACGU GAAACCCGGACUGAAGCAGGGGAGACCA--CUCUCCAACCCUAAAUACUAC-UA-UCACA CCGAUAGC-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CGCAGUGAGCGGAGU GAAAUAGAACCUGAAACCAUCUGCCUA-CAA-UCAUU-CAGAGCCCUA----------UG AUUUAU------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------CAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUGGACUGCCUUUUGCAUAAUGAUCCUG CGAGUUGU-G----GUAUCUGGCAA---GGUUAA-GC---------------AAAC---- ----------GC-G-A-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AA---------------- -------------------------------------------A-GGGCG---------- ---------------------------------------UU------------------- ------------------------UAGUCAGAUGCUGCA-GACCCGAAGCCAA-GUGAUC UAUCCAUGGCCAAGUUGAAGCGAGU-GUAAUAG-CUCGUGGAGGACUGA--ACUC-GUAC -CCAUUGAAACGGGUUGGGAUGAGCUGUGGAUAGGGGUGAAAGGCCAAACAAACUUGG-U GAUAGCUGGUUCUCUUCGAAAUAUAUUUAGGUAUAGCCUCAAG-U--------------- ------------------------------------------------------------ --------------------GAUA-GU-AAUAGGGGGUAGAGC-UCUGAUUGGG--CU-A GG--G-CUG-C-UCACC-GCGGUA-CCAACCCCUGUCAAACUACGAAUACCUA-UU--A- C-C--------------------------------------------------------- ------------------------------------------------------------ ----------G--UA-UC-UUGGG-AGU-CAG-GCG--GU-GGGUGAUAAAAUCAAU-CG -UCAAAA-GGGGA----ACA--ACCCAGACUACC-AACUAAG--GUCCC--AAAGUU--C U-A-UUCU-AAG--UGGAA-----------AAUGAUGUGAAGUUACUUAGACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAACAGCUCACUGGUC-----U AGUGAUUUUGCGCAGAAAAUAUAACGGGGCU--A-AGAUA---GAC--------ACC--G AAG-UUGUAGA--UUG---U--G----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UGAU----------------------------- ---------------------------------GC-A-C-A-GU-GG--UAGAA----GA ---G-CGUU-CGUA-UCA------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGGCA-U--A-CCGGUAA-GGA--GUGC-U-GGA-GCGAUG-C--GAAGUGAGCAUGC-A GGAAU-GAGUA-GCG-A--UAA-AAGUG-G------------------UGAGAAU----- ----------CCACUU-CGCC-GAA-AAUCU-AAGGUUUCCU-ACGCGAUGCUCGUCAUC GUAGGG------------UUAGUCGGGUC-C-UAA----GACA-A-GUCCGAA--AGGGG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAA-AAU-GGG--U UAA----UAUU-CCC----AUACC-A-AC-A--UUAG-U-G------------------- ----------------------------------------------------------UG CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GCAU-A GGGCUA--AA--U-GGCGU-U-AGC--UGA---UGGA----AAU---GC-UAA-U-UU-- -A------AGA------GC-G------U------A---G----A---------U----UG G-A------G---GA-AU-G--G-----A--AAA-U-CCG-CCUCU-GU----A-U---- -UU-G--A-AA-C--UCCA----A-UA-G--CU--UC-AAGC-GA-GC------------ ---------UU-CG-----------------------GC-UC-A--AU-UGG--AGU--G CC-A----UU-GAUGC-CGUC---GUGC-CAAGAAA-A-G-CCUC---U--A-AGU-UU- ------------------------------------------------------------ -A--GC-U-AAU--GU-U-GCCCGUACCGCAAACCGACACAGGUAGAUG-AGA-UGAGUA -U-UCUAAGG-CG-CG-UGAA-AGAACUCU-GGUUAAGGAACUCUGCAAAC-UAGCACCG UAAGUUCGCA-AUAAGGUGUGC-CU-AC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GUAG-GUCUCAGCAAAGAGUCCCUCCCGA-----CUGUUUAC CAAAAACACAGCACUUUGC-AAACUC--GU---A-A------------GAGGAA-GU-AU AAGGUGUG-ACGCCUGCCCGGUGC-U-CGAAGGUUAAGAGGAUUAGUU-AGCA----GCA A-----UGCG-AAGCUUUGAAUUGAAGCCCGA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGU-UAAAUACCGACCUGCAUGAAUGGCGUAACG AG-A--UGGGA--GCUGUCUCAA-CC-AGG-GAUUCAGUGAAAUUGUAGU-GGAGGUGAA AAUUCCUCCUACCCGCGGCAAGACGGAAAGA-CCCCGUGGACC-UUUACUACAGCUUGGC ACUGCCGAUGGGAGCAUUAUGCGCAGGAU-AGGUGGGAG-GC-UU-U-GAA--GUC--UU CAC--------------------------------------------------------- ----------------------------------UCUG--GUGGA--GAUGGAGC--CA- UCGU-UGAGAUA-CCACCCUUAAUGU-UUCUGUCUGCUAA-CUGGC--UU--------AU G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CA-U-AAG-CAGGA -CAA-UGCCUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAAGUAAC-GGAGG CUUGCAAAGGUUGGCUCAUUGCGGUUGGAAAUCGCAAGAA-GAGUGU-AAUGGCAUAA-G CCAGCCUGACUG-UAAGACAA-A----CAAGUCAAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------A---------UUCUG--UGU-GGA- -----------------------------AGGGUCAUCGCUCAAAGGAUAAAAGGUACCC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGCUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGGAGUAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----AGGAAAG-UUGAGGAGAG--CUGUCCCUAGUACGAGAGGACCGGGAUGGACACGC CAC-UGGUGUA-CCAGU-UGUUCUGCCAAGAGC-AU--CGCUGGGUAGCUA-C-GCGUGG AUG-UGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------AAC-UCCAAGA--- --UAAACUU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------CUG--AAGGUC---GCAG--C-AAGACUAGCU-GC-UUGAUAGG GUAGA-UGUGUAAG-CAU-A-------------------------GUAA----------- --UGUGU--U--UAGCU-----GACU----A-CUACUAA-UAGACC-GC--UUGG-CUUU -UCUUU-- >Legionella_pneumophila ------------------AAGCGCAAAC-GGUGGAUG-CCU-UGGCA-GUA-A--GAGGC GAAGAAGGACGUGGA-AUCCUGCGAAAAGCUAUGGGGAGCUGGAAACGA-GCGUU--GAG CCAUAGAUGUCCGAAUGGGGGAACCCGGCUGCCGA------------------------- ----------------U------------------------------------------- -----------------------------------GCGGUCA-------------UUU-G CAUUU--------------------------GAAUACAU-A------------------- ---------------GGUGC--AAAGGCGA-ACUCGGGGAACUGAAACAUCUAAGUACCC --GAAGGAAAAGAAAUCAA-GAGAGAUUCUCCAAGU-AGC-GGCGAGCGAACGGGG-AGG AGCCUGGC----GUGA-UU-------------------------UAUUA----------- ------------------------------------------------------------ -------------------U-------U-----GAACUGAG------UAG-AACA--AUU UG-GG-------AAAGU------U-GGCG-AUAGAGGGUGAAAGCCCCGUAUACGAAAGU -U-UGA-U-----------------------G-AACUCACGCGAGUAGGCCGGGACACGU GAAAUCCUGGUUGAAGAUGGGUGGACCA--UCAUCCAAGGCUAAAUACUAC-UU-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCGGAGAGGGGAGU GAAAUAGAAUCUGAAACCGUUUGCGUA-CAA-GCAGU-GGGAGCA-------------UG GU-----------------------UUU--------------G----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGAGUUAC-U----UUCAGUGGCGA---GGUUAA-CUG--------------AAU----- ---------AAG-G-G-A-GCCGUAGAGAAA-UCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------A------------------- ------------------------UAGUCGCUGGGAGUA-GACCCGAAACCGG-GCGAUC UAGCCAUGUGCAGGAUGAAGGUUGG-GUAACAC-CAACUGGAGGUCCGA--ACCG-GGUA -AUGUUGAAAAAUUAUCGGAUGACGUGUGGCUAGGAGUGAAAGGCUAAUCAAGCCCGG-A GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUG-A--------------- ------------------------------------------------------------ ---------------------AUG-AU-UACUGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGC-U-GUCAU-GGCUUA-CCAAACCGAUGCAAACUCCGAAUACCGG-CUA-A- U-U--------------------------------------------------------- ------------------------------------------------------------ ---------GA--AU--C-ACGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGGAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--CAAGUA--C U-A-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCAUAGACAGCCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCUA-A-AACUA---GUC--------ACC--G AAG-CUGCGGA--UGU---G--C----GC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAG----------------------------- --------------------------------GCG-C-A-C-GU-GG--UAGGG----GA ---G-CGUU-CUGUAGG-------------------CU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGUG-C--A-UUGA-GA-AGU--GUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-ACG-A--UAA-UGUGG-G------------------UGAAAAG----- ----------CCCACA-CGCC-GGA-AGUCC-CAGGUUUCCU-GCACGACGUUAAUCGGA GCAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCUGAA--GAGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-AGG--U UAA----UAUU-CCU----GGACU-U-UU-U--AUAA-G-U------------------- -----------------------------------------------------------G --A--------------------------------------------------------- ----------------------------------------AG-UGG-GG-AC--GAAG-A AGGCUA--GG--U-GA-GC-C-AGG--CGU---UGG-----UUGU--CC-UGG-U-AC-- -U------UGC------AU-G------U------A---G----G---G-----G----GG A-A------G---AC-UU-G--G-----C--AAA-U-CCG-GUUUU-CC----AUAAC-U -CU-G--A-GG-U--G--C-G--A-AG-U-GGU--UC-UGACC----------------- ---------UU-UU-----------------------------G--GA------GAA--G UC-A----UU-GAUGC-CCGG---CUUC-CAGGAAA-A-G-CUGC---U--A-GCC-AU- AA---------------------------------------------------------- -C--UU-A---U--AG-G-AACCGUACCGCAAACCGACACAGGUGGACA-GGU-AGAGAA -U-ACUAAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UGGUACCG UAACUUCGGG-AGAAGGUACGC-CC-UU--U-CU-GGUGAUG-GG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UUU-C-A----- G-----AGC-U-G--G-AGAGG-GCCGCAGAGACCAGGUGGCUGCGA-----CUGUUUAU UAAAAACACAGCACUCUGC-AAAUUC--GU---A-A------------GAAGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAUGGGGUU-AUC-----UUC ------GGAG-AAGCUCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAAAU-CGCUGUGAA GAUGCAGUGUACCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGUUUUGC ACUGGACUUUGAUGAUGACUGUGUAGGAU-AGGUGGGAG-GC-UG-U-GAA--GUG--AG GAC--------------------------------------------------------- ----------------------------------GCUA--GUUCU--CAUGGAGC--CG- CCCU-UGAAAUA-CCACCCUGUUGUU-AUUGAGGUUCUAA-CUUGG--UC--------CA G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CU-G-GAU-GAGGA -CAG-UGUAUGAUGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGCACAAAGGUACCCUCGGUACGGUCGGACAUCGUACCAA-GAGUGU-AAAGGCAAAA-G GGUGCUUGACUG-CGAGAGUG-A----CGGCUCGAGCAGGAACGAAAGUUGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----AGGAAAA-UUGAGAGGAG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGCA-CCGGU-UGUCACGCCAGUGGC-AU--GGCCGGGUAGCUA-A-GUUCGG ACG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UCC-CUCAAGA--- --UGAGUUU---------------------------UC--CC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------A--UGA---AG-CC---CGUU--G-AAGACUACGA-CG-UUGAUAGG CAAGG-UGUGGAAG-CGC-A-------------------------GUAA----------- --UGCGU--G--AAGCU-----AACU----U-GUACUAA-U------------------- -------- >Leifsonia_xyli -CAAGUUUCU--------AAGAGCAAAC-GGUGGAUG-CCU-UGGCA-UCU-G--GAGCC GAAGAAGGACGUAGU-AAUCUGCGAUAAGCCUCGGGGAGUUGAUAAACG-GACUUU-GAU CCGAGGAUUUCCGAAUGGGGAAACCCCGCUGGGCCC-----------------U-UU--- ---------------GG----------GUG------------------------------ ---------------------------------ACCCAGUGA-------------CUC-C CGCCU--------------------------GAAUAUAU-A------------------- ---------------GGGCGGGUAGAGGGA-ACGUGGGGAAGUGAAACAUCUCAGUACCC --ACAGGAAGAGAAAGCAA-AAGCGAUUCCGUUAGU-AGU-GGCGAGCGAAACCGG-AAG AGGCUAAA-CCGAUCAUGUGUGA-UAGCCG-GCAGGCG------UUGCAUGGUCGGGG-- -------------------------UUGCGGGACUUUUCUGCUGCU--UCUGCCGAACA- --GCAAGC--GUUACA--GA--------G---GAUCAUAGG------UG--AAUG--GCA UU-GA-------AAGGC------C-AGUC-AUAGAGGGUGCCAACCCCGUAACCGAAAUG -G-UCC--A---------AUG----GUGCGA-AGAGUAUCCCAAGUAGCACGGGGCCCGA GAAAUCUCGUGUGAAUCUGUCAGGACCA--CCUGAUAAGCCUAAAUACUCC-CA-GAUGA CCGAUAGC-GGACA-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-CCCGG-GAGGGGAGU GAAAUAGUACCUGAAACCGUUUGCUUA-CAA-ACCGU-UGGAGCCUCC----------UU G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------UAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACAGCGUGCCUUUUGAAGAAUGAGCCUG CGAGUUAGUG----AUAUGUGGCGA---GGUUAA-CCC--------------GUGA---- ---------GGG-G-U-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AUU------------------ ------------------------CAGUCGCAUGUCCUA-GACCCGAAGCGAA-GUGAUC UAUCCAUGGCCAGGUUGAAGCGACG-GUAAGAC-GUCGUGGAGGACCGA--ACCC-ACUU -AGGUUGAAAACUGAGGGGAUGAGCUGUGGAUAGGGGUGAAAGGCCAAUCAAACUUCG-U GAUAGCUGGUUCUCUCCGAAAUGCAUUUAGGUGCAGCGUUGCG-U--------------- ------------------------------------------------------------ --------------------GUUU-CU-UGCCGGAGGUAGAGCUACUGGAUGGC--CG-A UG--G-GCC-C-CAAAA-G-GUUA-CUGACGUCAGCCAAACUCCGAAUGCCGG-UA--A- GUG--------------------------------------------------------- ------------------------------------------------------------ ---------AG--AG--C-GCAGC-AGU-GAG-ACG--GU-GGGGGAUAAGCUUCAU-CG -UCGAGA-GGGAA----ACA--ACCCAGACCACC-AACUAAG--GUCCC--UAAGCG--C G-U-GC-U-AAG--UGGGA-----------AAGGAUGUGGAGUUGCACAGACAACCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAACAGCUCACUGGUC-----A AGUGAUUCCGCGCCGACAAUGUAACGGGGCUC-A-AGCAC---GCC--------ACC--G AAG-UUGUGGC--AUU---A--A----CA-U----------UA-UUGG-UA--------- ----GGCU---------------------------------------------------- ------------------------------------------------------------ ---------------------------UUCGU---------------------------- ------GGUCCA---GC----C---------GUGU-U-G-A-UG-GG--UAGGA----GA ---G-CGUC-GUGU-GG-------------------CG-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGCGG-C--G-GUGU-GA-ACCA-GCCG-U-GGA-CGCCAC-A--CGAGUGAGAAUGC-A GGCAU-GAGUA-GCG-A---AA-GACGG-G------------------UGAGAAA----- ----------CCCGUC-CUCC-GAA-AGACC-AAGGGUUCCA-GGGCCAGGCUAAUCCGC CCUGGG------------UAAGUCGGGAC-C-UAA----GGCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-GGG--U UGA----UAUU-CCC----GUACC-G-GC-G--AAGA-A-C----C----G--UCCA-AG CUAAU-CCAGUGGUGCUAAGAGUCC-UA-AUCCUGGAC-A-CCGAUCCC----------U UCG------GGG-U-G-ACGGUCCAGGUC-UA-ACGCUCGACCCCAUGCUGGU--GCGGC U-----AGC-G----------------------UAUUAACAG-GUG-UG-AC--GCAG-G AAGGUA--GC--U-GU-AC-C-GGG--CGA---UGGU----UGU---CC-CGG-G-GU-- -A------AGG------AU-G------U------A---G----G---G----------CG A-G------A---GA-UA-G--G-----C--AAA-U-CCG-UCUCU-CA----CAUAG-C -CU-G--A-GA-U--C--U-U--A-UG-C-AUA--GC-CG-------------------- ---------UC-A----------------------------------A-GGC--GAA--U UC-A----GU-GAUCC-UAUG---CUGC-CAAGAAA-A-G-CAUC---G--A-CGC-GA- ------------------------------------------------------------ -G--GU-U-CCA--GC-C-GCCCGUACCCCAAACCGACUCAGGUGGUCA-GGU-AGAGAA -U-ACUAAGG-AG-AU-CGAG-AGAAUCGU-GGUUAAGGAACUCGGCAAAA-UGCCCCCG UAACUUCGGG-AGAAGGGGGGC-CU--G--A-GG-CGUGAAG-GG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UCC-U-G----- G-----AGC-G-U--U-UGAAG-GCCGCAGAGACCAGUGGGAAGCGA-----CUGUUUAC UAAAAACACAGGUCCGUGC-CAAGUC--GC---A-A------------GACGAU-GU-AU ACGGACUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAAGGGUU-AGC-----UUC G------GCG-AAGCUCAGAAUUUAAGCCCCA-G-UAAACGG-CGGUGGUAACUAUAACC AUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCA--GCUGUCUCAA-CC-ACG-AACUCGGCGAAAUUGCACU-ACGAGUAAA GAUGCUCGUUACGCGCAGCAGGACGGAAAGA-CCCCG-UGACC-UUUACUAUAGUUUGGU AUUGGUGUUCGGUGUGGCUUGUGUAGGAU-AGGUGGGAG-AC-UU-U-GAA--GCG--GG CAC--------------------------------------------------------- ----------------------------------GCCA--GUGUU--CGUGGAGU--CA- UUUU-UGAAAUA-CCACUCUGGUCAU-UCUGGAUAUCUAA-CUUAG--AA--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-UUC-AGGGA -CAG-UGCCUGAUGGGUAGUUUAACUGGGGCGGU-UGCCUCCCA-AAAAGUAAC-GGAGG CGCCCAAAGGUUCCCUCAACCUGGUUGGCAAUCAGGUGUC-GAGUGU-AAGUGCACAA-G GGAGCUUGACUG-UGAGACUG-A----CAAGUCGAGCAGGGACGAAAGUCGGGACU-AGU G-AUCCGGCA-------------------------G---------UGGCU--UGU-GGA- -----------------------------AGCGCUGUCGCUCAACGGAUAAAAGGUACCU CGGGGA-UAACAGGCUGAUCUUGCCCAAGAGUCCAUAUCGACGGCAUGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGUAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGCUG --CGC--G-C-G------------------------------------------------ ----CAGGAAAU-UUGAGAGGAU--CUGACCCUAGUACGAGAGGACCGGGUUGGACGAAC CUC-UGGUGUG-CCAGU-UGUUCCGCCAGGAGC-AC--CGCUGGUUAGCUA-C-GUUCGG GAU-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------GGC-CUCAAGA--- --UGAGAUU---------------------------UC--CA---------CG-C--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUCG----------------------------- ----------GGCG---AG---AGGCU---CCCA--GCUAGACUACUG-GG-UUGAUAGG CCGGA-UGUGGAAG-UGG-GGA-----------------------CUAAA---------G -ACCCAU--G--GAGCU-----GACC----G-GUACUAA-UAAGCC-GA---UAA-CUUG -AU----- >Listeria_monocytogenes --GGUUAAGU---U-AGAAAGGGCGCAC-GGUGGAUG-CCU-UGGCA-CUA-G--GAGCC GAAGAAGGACGGGAC-UAACACCGAUAUGCUUUGGGGAGCUGUACG-UA-AGCGU-UGAU CCAGAGAUUUCCGAAUGGGGGAACCCACUAUC-UUUA----------------------- ---------------GU------------------------------------------- ---------------------------------CGGAUAGUA-------------UCC-U UACGU--------------------------GAAUACAU-A------------------- -------------GCGUGAGGAAGG-CAGA--CCCAGGGAACUGAAACAUCUAAGUACCU --GGAGGAAGAGAAAGAAA-AAUCGAUUUCCUGAGU-AGC-GGCGAGCGAAACGGAA-AG AGCCCAAA-CCAAGAA--GC-----------UU-----------G---CUUCUUGGGG-- -------------------------UUGUAGGACACUCUA-------------------- ----UACGGAGUUACAAAAG--------A---AAGUUAUAA------AUG-AAGCG-GUC UG-GA-------AAGGC------C-CGCC-AAAGACGGUAACAGCCCGGUAGUUGAAAUA -G-CUU-UC---------CCU----CCAGAG---UGGAUCCUGAGUACGGCGGAACACGU GAAAUUCCGUCGGAAUCCGGGAGGACCA--UCUCCCAAGGCUAAAUACUCC-CU-AGUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GAAGGGGAGU GAAACAGUUCCUGAAACCGUGUGCCUA-CAA-GUAGU-UAGAGCCCGU----------UA AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUAGCGUGCCUUUUGUAGAAUGAACCGG CGAGUUAC-G----AUUUGUUGCAA---GGUUAA-GCG-------------GAAAA---- ---------AGC-G-G-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------CAU------------------ ------------------------AAGUAACAGGUCGUA-GACCCGAAACCAG-GUGAUC UACCCAUGUCCAGGAUGAAGGUAAG-GUAAUAC-UUACUGGAGGUCCGA--ACCC-ACGC -ACGUUGAAAAGUGCGGGGAUGAGGUGUGGGUAGCGGAGAAAUUCCAAUCGAACUUGG-A GAUAGCUGGUUCUCUCCGAAAUAGCUUUAGGGCUAGCCUCGAG-G--------------- ------------------------------------------------------------ -------------------UAAAG-AG-UCAUGGAGGUAGAGC-ACUGUUUGGA--CU-A GG--G-GCC-C-UUCUC-GGGUUA-CCGAAUUCAGAUAAACUCCGAAUGCCAUGUA--C- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UA--C-UCGGG-AGU-CAG-ACU--GC-GAGUGAUAAGAUCCGU-AG -UCGAAA-GGGAA----ACA--GCCCAGACCACC-AGUUAAG--GUCCC--CAAAUA--U A-U-GU-U-AAG--UGGAA-----------AAGGAUGUGGGGUUGCUUAGACAACCAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----G AGUGACCCCGCGCCGAAAAUGUACCGGGGCU--A-AACAU---AUU--------ACC--G AAA-CUGUGGA--UGA---A--C----CU-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- -------------------------------GAGG-U-U-C-GU-GG--UAGGA----GA ---G-CGUU-CUAAG-G-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGUCA-G--A-CCGG-AA-GGA--CUGG-U-GGA-GCGCUU-A--GAAGUGAGAAUGC-C GGUAU-GAGUA-GCG-A---AA-GAAGG-G------------------UGAGAAU----- ----------CCCUUC-CACC-GAA-UAUCU-AAGGUUUCCU-GAGGAAGGCUCGUCCGC UCAGGG------------UUAGUCGGGAC-C-UAA----GCCG-A-GGCCGAU--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGAC-AAC-AGG--U AGA----GAUU-CCU----GUACC-A-GU-G--CUAA-U-U------------------- ----------------------------------------------------G-UUUAAC CGA--------------------------------------------------------- ----------------------------------------UG-GGG-UG-AC--ACAG-A AGGAUA--GG--G-AA-UC-G-CAC--GAA---UGGA----AAU---GU-GCG-U-CC-- -A------AGC------AG-U------G------A---G----U---G-----U----GA G--------A---AG-UA-G--G-----C--AAA-U-CCG-CUU-C-UC----GCGAAGC -AU-G--A-GC-U--G--U-G--A-UG-G-GGA--AG-GAA------------------- ---------AU-UAA-------------------------------GU-ACG--GAA--G UU-C----CU-GAUUU-CACG---CUGU-CAAGAAA-A-G-CCUC---U--A-GGA---- -A---------------------------------------------------------- -G--AG-U-AGU--AC-U-GCCCGUACCGCAAACCGACACAGGUAGAUG-AGG-AGAGAA -U-CCUAAGG-UG-AG-CGAG-AGAACUCU-CGUUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-UC-UA--UUAG-GGU---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GC-C-C--G-AGAGA-GCCGCAGUGAAUAGGCCCAGGCGA-----CUGUUUAG CAAAAACACAGGUCUCUGC-AAAACC--GU---A-A------------GGUGAC-GU-AU AGGGGCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGUGCUU-AGC-----UUC G------GCG-AAGGUACGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGCAACG AU-C--UGGGC--ACUGUCUCAA-CG-AGA-GACUCGGUGAAAUUAUAGU-ACCUGUGAA GAUGCAGGUUACCCGCGACAGGACGGAAAGA-CCCCGUGGAGC-UUUACUGCAACCUGAU AUGGAAUGUUUGUACCGCUUGUACAGGAU-AGGUAGGAG-CC-G--AAGAG--ACG--UG UGC--------------------------------------------------------- ----------------------------------GCUA--GCAUA--CGAGGAGG--CA- AUGG-UGGGAUA-CUACCCUGGCUGU-AUGACCAUUCUAA-CCCGC--CA--------CG C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GC-G-UGG-GGAGA -CAG-UGUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGAGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGAAUGGAUGGAAAUCAUUCGCA-GAGUGU-AAAGGCACAA-G GGAGCUUGACUG-CGAGACUG-A----CAAGUCGAGCAGGGACGAAAGUCGGGCUU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGCUACCC CGGGGA-UAACAGGCUUAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --CGG--G-CGC------------------------------------------------ -----AGGAAAU-UUGAGAGGAG--CUGUCCUUAGUACGAGAGGACCGGGAUGGACACAC CGC-UGGUGUA-CCAGU-UGUUCCGCCAGGAGC-AU--CGCUGGGUAGCUA-U-GUGUGG CAG-GGAUAAACGCUGAAAGCAUC--U-AAGCGUGAAGCC------CCC-CUCAAGA--- --UGAGAUU---------------------------UC--CCA--------UU-U--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUCG----------------------------- ----------GAAA---GU--AAGAUC---CCUG--A-AAGAUGAUCA-GG-UAGAUAGG UUUGG-AGUGGAAG-UGU-A-------------------------GCGA----------- --UACAU--G--GAGCG-----GACA----A-AUACUAA-UCGAUC-GA---GGA-CUUA -ACCA--- >Magnetococcus_sp. ------AAGU---AAACGAAGGGCAUAC-GGUGGAUG-CCU-UGGUG-CCA-A--GAGGC GAUGAAGGACGUAGC-ACGUUGCGAUAAGCUUCGGAGAGCCGCGAG-CA-GGCUUU-GAC CCGGAGAUUUCCGAAUGGGGAAACCCGGCGGGAUGAA----------------------- ------------------------------------------------------------ ---------------AUC------------------CCGUCA-------------CUA-C UAGCU--------------------------GAAUAAAU-A------------------- ---------------GGC-UAUUAGAGCGA-ACGCGGGGAACUGAAACAUCUAAGUACCC --GUAGGAACAGAAAUCAA-UUGAGAUUCCCUAAGU-AGC-GGCGAGCGAACGGGG-ACC AGGCCAGU-AU-CAU------------------------------AA-A----------- ------------------------------------------------------------ ---------------------------------UCAUUUAG------CCG-AACC--AAC UG-GA-------AAGUU------G-GACC-AUAGUGGGUGAAAGUCCUUUAGGUGAAAGG -G-CGU-GU---------A---------UGAG-GGAUACGAAGAGUAGGGCGGGACACGU GAAAUCCUGUCUGAACAUGGGGGGCCCU--CCCUCCAAGCCUAAAUACUAC-UU-GGCAA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCGAUAAGGGGAGU GAAAUAGAACCUGAAACCGUAUGCUUA-CAA-GCAGU-CGGAGGC-------------UG AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------AA---------------G----CCUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGAGUUAA-U----CUGCGUAGCAA---GCUUAA-GC---------------GA-A---- ---------AGU-G-U-A-GGCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------AAGUUUCGUAGAUUA-GACCCGAAACCGA-GUGAUC UACCCAUGGUCAGGUUGAAGGUGCG-GUAACAC-GCACUGGAGGACCGA--ACCC-ACCU -AUGUUGAAAAAUGGGGGGAUGAACUGUGGGUAGGAGUGAAAGGCUAAACAAACUCGG-A AAUAGCUGGUUCUCUCCGAAAACUAUUUAGGUAGUGCCUCGAA-U--------------- ------------------------------------------------------------ ---------------------UGG-CA-UGCCGGGGGUAGAGC-ACUGGAUGGG--CU-A GG--G-GGG-C-CCAAA-GCCUUA-CCAAACCUAACCAAACUCCGAAUACCGG-UCA-G- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UA-GU-UCGGG-AGA-CAG-ACU--GC-GGGUGCUAAGGUCCGU-AG -UCGAGA-GGGAA----AAA--GCCCAGACCAUC-AUCUAAG--GUCCC--CAAGUC--A U-A-CU-U-AAG--UGGGA-----------AAGGAUGUGGGAAUGCCCUGACAGCCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUGGUCCUGCGCCGAAAAUAUAACGGGGCUC-A-AAGUA---UGC--------ACC--G AAG-AUAUGGA--UGC------C----G-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------C-------------------------------- ---------------------------------GA-G-G-C-AU-GG--UAGGA----GA ---G-CGUU-CCGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCCG-U--A-CCGA-GA-GGA--GCGG-U-GGA-GGUAUC-G--GAAGUGAGAAUGC-U GACAU-GAGUA-ACG-A--UAA-UCAAG-G------------------UGAGAAU----- ----------CCUUGA-CGCC-GAA-AACCC-AAGGUUUCCU-ACGCAAGGCUAUUCCGC GUAGGG------------UUAGUCGGCCC-C-UAA----GGUG-A-GGCAUAC--AUGCG ---------------------------U-A-A---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-U-CU-U--AUAA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GGAG-A AGGAUA--GA--U-CU-AC-C-GGG--CGU---UGG-----UAGU--CC-CGG-G-AC-- -A------AGC------GU-G------U------A---G----G---U-----U----GA C-A------G---AC-UA-G--G-----U--AAA-U-CCG-GACUG-UU----AAG---A -CU-G--A-GG-C--G--U-G--A-UG-U--GG--AG-CCAC------------------ ---------UA-G------------------------------G--CG-AAC--UGA--U U--G----AU----UCCA-AG---CUUC-CAAGAAA-A-G-CCUC---U--A-AGC-UUC A----------------------------------------------------------- -G--GU-U-AUG--AG-A-GACCGUACCCCAAACCGACACAGGUGGGUG-GGA-UGAGAA -U-UCUAAGG-CG-UG-UGAG-AGAACUCU-GGUAAAGGAACUCGGCAAAU--GC-CCCG UAACUUCGGG-AGAAGGGGUGC-CU-CU--U-GUAUGUGAAG-GC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CU UU-ACG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GC-U-G----- G-----AGC-A-G--A-AGGGG-GCCGCAGUGACUAGGGGGGAGCGA-----CUGUUUAC CAAAAACAUAGGACUCUGC-UAAAUC--GC---A-A------------GAUGAA-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGGGGU----------GCA A------------GCUCUGAAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--GCUGUCUCUA-UC-AGA-GGCUCAGUGAAAUUGAAUU-UGCUGUGAA GAUGCAGCAUACCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUUGC AUUGGUACUAGAGACAGUUUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GCG--UG AGC--------------------------------------------------------- ----------------------------------GCCA--GCUCA--UGUGGAGC--CA- CCCUU-GAAAUA-CCACCCUGGCUCU-CUUUGGUAUCUAA-CUGCG--CG--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-CGU-CAGGA -CAG-UGCAUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCCA-AACAGUAAC-GGAGG CGCACGAUGGUUCGCUCAGGUUGGUCGGAAAUCAACCGUA-GAGUGU-AAUGGCAUAA-G CGAGCCUGACUG-UGAGACUG-A----CAAGUCGAGCAGGUACGAAAGUAGGUCAU-AGU G-AUCCGGCG-------------------------A---------UUCCG--AGA-GGA- -----------------------------AGGGUCGUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGUUGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ ------GGAAAA-UUGAGAGGAU--CUGCUCCUAGUACGAGAGGACCGGAGUGGACAAGC CUC-UGGUGUU-CGGGU-UGUCGUGCCAACGGC-AU--CGCCCGGUAGCUA-C-GCUUGG AAG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACC------CAC-CUCAAGA--- --UGAAUUU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CUAU--GAGAUC---CGUG--G-AAGACCACCA-CG-UUGAUAGG CAGGA-UGUGGAAG-UGG-G-------------------------GUAA----------- --CCCAU--G--CAGCU-----AACC----U-GUACUAA-UCGAUC-CA--CUGA-CUUC -UA----- >Magnetospirillum_magnetotacticum ----UCAAGC---GUCAAAAGGGCAUUU-CGUGGAUG-CCU-UGGCA-CUG-A--GAGGC GAUGAAGGACGUGGC-ACUCUGCGAAAAGCCACGGGGAGCCGAGAG-CA-GGCUUU-GAU CCGUGGAUAUCCGAAUGGGGAAACCCCACCGUAAGG------------------------ ------------------------------------------------------------ ---------------------------------------UGA-------------UCC-C ACACU--------------------------GAAUACAU-A------------------- ---------------GGU--GUGGGAGGCGAACCGGGCGAACUGAAACAUCUAAGUAGCC --CGAGGAAAGGACAUCAA-CCGAGACUCCGCUAGU-AGU-GGCGAGCGAACGCGG-ACC AGCCCAGU-GA-UGU------------------------------UG-U----------- ------------------------------------------------------------ -------------------G-------------UACAUAAU------CUG-AACC--GUC UG-GA-------AAGUC------G-GGCC-AUAGAGCGUGAUAGCCGCUUAAGAGUAAAC -C-G-C-AC---------A---------GCA------UCCUCGAGUAAGGCGGGACACGU GAAAUCCUGUCUGAACAUGGGGGGACCA--CCCUCCAAGGCUAAGUACUCC-UC-AGUGA CCGAUAGC-GAACU-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGACAAGGGGAGU GAAAUAGUACCUGAAACGGAAUGCCUA-CAA-GCAGU-CGGAGCCC-------------- ------------------------------------------------CCU--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGAGUUAG-U----GUAUGCAGCAA---GCUUAA-GCC--------------GGUA---- ---------GGC-G-U-A-GGCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------AC------------------ ------------------------GAGUUGCAUGCAUUA-GACCCGAAACCGG-GUGAUC UAGCCAUGGGCAGGUUGAAGGUGGG-GUAACAC-CCACUGGAGGACCGA--ACUC-ACGU -CUGUUGAAAAAGACGGAGAUGACCUGUGGUUAGGGGUGAAAGGCCAAUCAAACUCGG-A AAUAGCUGGUUCUCCGCGAAAGCUAUUUAGGUAGCGCCUCGGA-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-CUACGGGGGUAGAGC-ACUGGAUGGG--CU-A GG--G-GGU-C-CCAAA-GACCUA-CCAAACCUAACCAAACUCCGAAUACCGU-AGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--U-CCGGG-AGA-CAG-ACG--GU-GGGUGCUAAGGUCCAU-CG -UCAAAA-GGGAA----ACA--GCCCAGACCGCC-AGCUAAG--GUCCC--CAAGUC--A U-G-GU-U-AAG--UGGGA-----------AAGGAUGUAAGACGGCCAAAACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAAUAGCUCACUGGUCUAA-U- AGCUGUCUCGCGCCGAAAAUGUACCGGGGCUC-A-AACCA---UGC--------ACC--G AAG-CUGCGGG--UGU---G--C----A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------UG-C-A-C-GC-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGCG-UC-A-UCGU-GA-GAG--GCGC-U-GGA-GGUAUC-G--GAAGUGAGAAUGC-U GACAU-GAGUA-GCG-A--CAA-ACAGU-G------------------UGAGAAA----- ----------CACUGU-CGCC-GAA-AGUCC-AAGGGUUCCU-GCGCAAGGCUAAUCCGC GCAGGG------------UAAGCCGGCCC-C-UAA----GGCG-A-GGGCGAA--AGCCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-ACG--U UAA----UAUU-CGU----GGGCC-U-GC-U--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GA-AGU--G-AC--GACC-U CCGUGU--AU--C-GU-AU-C-CUC-UUAU---CGG-----AUU---GA-GGG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GC-G----GU----GAAG-GG---GGUC-CAGGAAA-U-A-ACUC---C--A-------- ------------------------------------------------------------ ---------GCG--UAUA-GACCGUACCCUAAACCGACACAGGUGGACU-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAACGAU-GUUGAAGGAACUAGGCAAAU-UGACCCCG UAACUUCGGG-AUAAGGGGUAC-CU-CU-----------CUU-UG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCA-G-A----- G-----------------GGGG-GUGGCACAGACCAGGGGGUGGCGA-----CUGUUUAC UAAAAACACAGGGCUCUGC-GAAGUC--GA---A-A------------GACGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAAAGGAGGGGU----------GCA A------------GCUCUGAAUUGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--GCUGUCUCCA-AC-AUC-GACUCAGCGAAAUUGAAUU-CUCCGUGAA GAUGCGGAGUACCCGUGGCUAGACGGAAAGA-CCCCGUGCACC-UUUACUACAGCUUUGC AGUGGUACUAGGAUGUGGAUGUGUAGGAU-AGGUGGGAG-CC-UA-U-GAA--GCA--CC GGC--------------------------------------------------------- ----------------------------------GCCA--GCUGG--UGUGGAGG--CA- ACCU-UGAAAUA-CCACCCUUCUGCU-UCCUGGUAUCUAA-CCGCG--CC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAACC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GGC-CGGGA -CCC-UGCAUGGCGGGUAGUUUGACUGGGGCGGU-CGCCUCCCA-AAGAGUAAC-GGAGG CGCGCGAUGGUGGGCUCAGGCUGGUCGGAAAUCAGCUGUC-GAGUGC-AAUGGCAUAA-G CCCGCCUGACUG-CGAGACAA-A----CAAGUCGAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--CGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGUGGUACGUGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUACCA --UGG--G-UGU------------------------------------------------ -----UGGAAAC-UUGAGAGGAC--CUGUCCCUAGUACGAGAGGACCGGGAUGGACAUAC CUC-UAGUGUA-CCGGU-UGUCGCGCCAGCGGC-AU--CGCCGGGUAGCCA-U-GUAUGG ACG-AGAUAACCGCUGAAUGCAUC--U-AAGCGGGAAGCU------CCC-CUCAAAA--- --CCAGGUU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CUAU--CAGAGC---CGUG--G-AAGACCACCA-CG-UUGAUAGG CAGCA-UGUGGAAG-CGU-G-------------------------GUAA----------- --CACGU--G--AAGCU-----AAGC----U-GUACUAA-UCGCUC-GA--UCGG-CUUG -AUCGC-- >Mesoplasma_florum ----------------GUAAGGGCACAU-GGUGAAUG-CCU-UGGAA-AAU-G--GAGCC GAAGAAGGACGUGAU-UACCUGCGAAAAGCAUCGGGGAGCUGGAAG-UG-AGCUU-UGAU CCGGUGAUAUCCGAAUGGGGAAACCCAAUACG-AUUA----------------------- ---------------AU------------------------------------------- ---------------------------------CUCGUAUUA-------------UCC-A UAAGU--------------------------GAAUACAU-A------------------- ---------------GCUUAUGAGAAGGGA-ACCUUGGGAACUGAAACAUCUUAGUACCA --AGAGGAAAAGAAAAUAAAUAAUGAUUCUGUUAGU-AGC-GGCGAGCGAAAGCGGA-AG AGGCCAAA-CCAGU-----------------CU-----------A---CGGGCUGGGG-- -------------------------UUGUAGGACAUCUU--------------------- ----UUUAGAGUUACAAAAU--------C---AACAUAUAG------UAG-AAGU--UAC UG-GG-------AAGUA------A-CGGC-AUAGAGGGUGAUACCCCCGUAUACGAAAUG -U-GUU-GA---------UCU----CUUAGA---UGGAUCCUGAGUACGGCGAAACACGU GAAAUUUUGUCGGAAUCCGCCGAGACCA--CUCGGCAAGCCUAAAUACUCC-CA-UUUUA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-CCCG-AGAGGGGAGU GAAAUAGUUCCUGAAACCAUGUGCUUA-CAA-GAAGA-UAGAGCCCGU----------UA AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUAUCGUGCUUUUUGUAGAAAGAGCCGG CGAGUUAA-U----GUAUCGUGCGA---GGUUAA-GCA-------------GAAUA---- ---------UGC-G-G-A-GCCGUAGUGAAA-GCG------------------------- ---------------------------------------------------------AGC CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------UAGUACGUUGCAUUA-GACACGAAACCGG-GUGAUC UAGCCAUGAGCAGGUUGAAGUUUGG-GUAAAAC-CAAAUGGAGGACCGA--ACCG-ACGU -UCGUUGAAAUGACCGCGGAUGACUUGUGGCUAGCGGUGAAAUUCCAAUCGAACCCGG-A GAUAGCUAGUUCUCCCCGAAAUAUAUUUAAGUAUAGCGUCGAGGU--------------- ------------------------------------------------------------ --------------------UUAC-CA-CAAUGGAGGUAGAGC-ACUGAAUCUA--UG-A UG--G-CCC-CACCUA--GGGGUA-CUGAAUAGAAUUAAACUCCGAAUGCCAUUGU--C- G-G--------------------------------------------------------- ------------------------------------------------------------ ----------A--UA--C-UCGGC-AGU-CAG-AAC--AU-GGGUGAUAAGGUCCAU-GC -UCGAGA-GGGAA----ACA--GCCCAGAUCGUC-AGCUAAG--GUCCC--UAAAUU--U A-G-GU-U-AAG--UGUGU-----------AAGGAUGUGGAAUUGCACAGACAGCUAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAGAGUGCGUAACAGCUCACUAGUC-----G AGUGAUUCUGCGCCGAAAAUGUACCGGGGCU--A-AACCU---AAU--------ACC--G AAG-CUACGGA--UUG---A--U----UU------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAA----------------------------- ---------------------------------AU-A-C-A-GU-GA--UAGGG----GA ---G-CGUU-CUAAU-U-------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGUCA-G--A-CUGU-GA-GGA--CUGG-U-GGA-ACGAUU-A--GAAGUGAUUAUGC-C GGCAU-GAGUA-ACG-A----U-UGAAU-G------------------UGAGAAU----- ----------CAUUCA-UACC-GUU-UGACC-AAGGUUUCCU-GGGCAAGGUUCGUCCAC CCAGGG------------UUAGUCAGGAC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-AGG--U UGA----UAUU-CCU----GUACC-U-GC-U--AGUU-A--------------------- -----------------------------------------------------------G UGA--------------------------------------------------------- ----------------------------------------UG-GAG-UG-AC--GGAG-A AAGGUA--GU--G-UA-UC-C-CAG--GUG--AUGGA----UGU---CC-UGG-G-UU-- -A------AGC------AC-A------A----------A----G---G-----C----GG C-A------A---CA-UA-G--G-----C--AAA-U-CCG-UGUUG-UA----UAAAC-G -CU-G----GU-U--A--U-G--A-GG-A-GUG-AAC-GGUUC----------------- ----------G-CC----------------------------UA--GU-AAC--GAA--G UA-C----AU-GACCC-UACG---CUUC-CAAGAAA-A-G-CUUC---U--A-ACU-U-- -A---------------------------------------------------------- -A--UA-A-CUA--GU-A-GCCUGUACCUAUAACGAACACACGUGGUCA-AGG-AGAAAA -U-CCUAAGG-UA-AG-CGAG-AUAACUGU-AGCUAAGGAACUCUGCAAAA-UAACUCCG UAACUUCGGA-AGAAGGAGUGC-UC-AA--C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GUUGA-GCCGCAGUGAAGAGGGAGGGGCAA-----CUGUUUAG CAAAAACACAGCUCUCUGC-UAAGUC--GC---A-A------------GACGAA-GU-AU AGGGGGUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGAGGAGAAGUC-AGC-----GCA A------GCG-AAGCUUCGAAUUGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCAGG-UAAGUUCUGACCCGCACGAAAGGCGUAAUG AU-C--CCUUC--GCUGUCUCGG-CU-GCA-GACUCGGUGAAAUUUUAGU-ACCGGUGAA GAUGCCGGUUACCCGCAACUAGACGGAAAGA-CCCCGUGGAGC-UUUACUAUAACUUGAU AUUGAAAUUUGGUAUAACGUGUAGAGGAU-AGGUGGGAG-ACUU--U-GAA--GCU--GG ACC--------------------------------------------------------- ----------------------------------GCUA--GGGCC--AGUGGAGU--C-A ACCU-UGGAAUA-CCACCCUCGUUAU-AUUGGAUUUCUAA-CUUCG--AC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUU-AAGGA -CAG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAUGUAAC-GGAGG CGCUCAAAGUUACACUCAGCAUGGUUGGAAAUCAUGCAUA-GAGCGC-AAAAGUAUAA-G UGUGAUUGACUG-UGAGACUU-A----CAAGUCGAACAGGUACGAAAGUAGGAUUU-AGU G-AUCCGGCG-------------------------G---------UCCCG--UGU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGUUACCC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGAGCUGUAGUCGGUUCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUUGGUCCCUAUCUGUUG --UGG--G-CGU------------------------------------------------ -----AGGAAAA-UUGAAGAGAG--CUGUUCCUAGUACGAGAGGACCGGAAUGGACACAC CUC-UGGUGCU-CCUGU-UGUCACGCCAGUGGC-AC--AGCAGGGUAGCUA-U-GUGUGG AAC-GGAUAAUCGCUGAAGGCAUC--U-AAGCGAGAAGCC------UCC-UUUAAGA--- --UGAAUUU---------------------------UC--CCA--------UU-U--C-- U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- ----------GAAU---GU--AAGAUC---CCUU--A-UAGACUAUGA-GG-UUGAUAGG AUGGA-UGUGUAAG-UGU-C-------------------------GCGA----------- --GGCAU--U--AAGCU-----AACC----A-UUACUAA-UAGAUC-GAG--AGAAUUUU -AG----- >Mycobacterium_leprae --AAGUAAGU---G-CCUAAGGGCGCAU-GGUGGAUG-CCU-UGGCA-UCG-A--GAGCC GAUGAAGGACGUGGG-AGGCUGCGAUAUGCCUCGGGGAGCUGUCAACCG-AGCGUG-GAU CCGAGGAUUUCCGAAUGGGGAAACCCAACA-----CG----------------AGUC--- ---------------AU------------------------------------------- ---------------------------------GUCGUGUUA-------------CCC-G UAUCU--------------------------GAAUAUAU-A------------------- ---------------GGG-UUCGGGAGGGA-ACGCGGGGAAGUGAAACAUCUCAGUACCC --GUAGGAGAAGAAAACAA-UUGUGAUUCCGCAAGU-AGU-GGCGAGCGAACGUGGAAUA UGGCUAAA-CCGCACACAUGUCU-AACUAG-GUAGGGG------UUGUGUGUGCGGUG-- -------------------------UUGUGGGAUUGGUAUGUCUCAACUCUACCUGGUU- --GAGGGGUAGUCAGA--AAGU-----GC---CGUGGUUAG------CGGAAAUG--GCC UG-GG-------AUGGC------C-UGCC-GUAGACGGUGAGAGCCCAGUACGCGAAAGC -C-UGG-CA---------CCU----GCCUUGUAUCAAUUCCCGAGUAGCAGCGGGCCCGU GGAAUCUGCUGUGAAUCUGCCGGGACCA--CCCGGUAAGCCUAAAUACUUC-UC-GAUGA CCGAUAGC-GGAUC-AGUACCGUGAGGGAAUGGUGAAA-AGUAC-CCCGG-GAGGGGAGU GAAAUAGUACCUGAAACCGUGUGCCUA-CAA-UCCGU-CAGAGCCUCU----------UU GU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------G-G------------GGUGAUGGCGUGCUUUUUGAAGAAUGAGCCUG CGAGUCAGGG----ACAUGUCGCGA---GGUUAA-CCC--------------GUGU---- ---------GGG-G-U-A-GCCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG-----UAU-C AC-G-U---------------------------------GUGA----------------- --------GCG-U-G---UG----UAGUGGCGUGUUCUG-GACCCGAAGCGGA-GUGAUC UACCCAUGGCCAGGGUGAAGCGCGG-GUAAGAC-CGCGUGGAGGCCCGA--ACCC-ACUU -AAGUUGAAGAUUGAGGGGAUGAGUUGUGGGUAGGGGUGAAAGGCCAAUCAAACUCCG-U GAUAGCUGGUUCUCCCCGAAAUGCAUUUAGGUGCAGCGUUGCG-U--------------- ------------------------------------------------------------ --------------------GGUU-CA-CCACGGAGGUAGAGCUACUGGAUGGC--CG-A UG--G-GCC-C-UACU--AGGUUA-CUGACGUCAGCCAAACUCCGAAUGCCGU-GG--U- UUA--------------------------------------------------------- ------------------------------------------------------------ ---------AA--AG--C-GUGGC-AGU-GAG-ACG--GC-GGGGGAUAAGCUCCGUACG -UCGAAA-GGGAA----ACA--GCCCAGAUCGCC-GGCUAAG--GCCCC--UAAGCG--U G-U-GC-U-AAG--UGGAA-----------AAGGAUGUGCAGUCGCAAAGACAACCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGUGAUUGUGCGCCGAUAAUGUAGCGGGGCUC-A-AGCAC---ACC--------GCC--G AAG-CCGCGGC--ACA---U--U----CA-C---------------CU------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UCUA----------------------------- ----------------G----G---------GUGG-A-U-G-UG-GG--UAGGG----GA ---G-CGUU-CCUC-AU-------------------UC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGCCU-C--C-GGGU-AA-CCG--GUGG-U-GGA-GGGUGG-G--GAAGUGAGAAUGC-A GGCAU-GAGUA-GCG-A--UAA-GGCAA-G------------------UGAGAAC----- ----------CUUGCC-CGCC-GUA-AGACC-AAGGGUUCCU-GGGCCAGGCCAGUCCGC CCAGGG------------UGAGUCGGGAC-C-UAA----GGCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-GGG--U UGA----UAUU-CCC----GUACC-C-GU-G--UGUG-U-G----C----G--CCCG-UG AUGAA-UCAGCGGUACUCACCACCCAAAACCGGAUCGACCAUAU--CCCC---------U UCG-----GGGGCU-AUGGA--GGUUCGGGGCUGCGUGGGA-ACUUCGUUGGUAGUAGUC A-----AGC-G----------------------------AUG-GGG-UG-AC--GCAG-G AAGGUA--GC--C-GU-AC-C-AGU--CAG---UGGU----AAU---AC-UGG-A-GC-- -A------AGC------CC-G------U------A---G----G---G----------AG A-G------C---GA-UA-G--G-----C--AAA-U-CCG-UCGUU-CG----U-GAAUC -CU-G--A-GA-G--G--U-G--A-UG-C-AUA--GC-CG-------------------- ---------AU-UG---------------------------------A-GGC--GAA--U UC-G----GU-AAGCC-UCUG---CUGC-CAAGAAA-A-G-CCUC---U--A-GCG--A- G----------------------------------------------------------- -C--AU-A-CAU--GC-G-GCCCGUACCCCAAACCGACACAGGUGGUCA-GGU-AGAGCA -U-ACCAAGG-CG-UA-CGAG-AUAACUAU-GGUUAAGGAACUCGGCAAAA-UGCCUCCG UAACUUCGGG-AGAAGGGGGGC-CG-GA-AU-AU-CGUGAAC-AC-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGU-G-G----- G-----AGC-G-G--G-AUCCG-GUCGCAGAGACCAGUGAGAAGCGA-----CUGUUUAC UAAAAACACAGGUCCGUGC-GAAGUC--GU---A-A------------GACGAU-GU-AU ACGGACUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGACCUGUU-AACCC---GAA A----GGGUG-AAGCGGAGAAUUUAAGCCCCA-G-UAAACGG-CGGUGGUAACUAUAACC AUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCUCA--ACUGUCUCAA-CC-AUA-GACUCGGCGAAAUUGCACU-ACGAGUAAA GAUGCUCGUUACGUGCGGCAGGACGAAAAGA-CCCCG-GGACC-UUCACUACAACUUGGU AUUGAUGUUCGGUGCGGUUUGUGUAGGAU-AGGUGGGAG-AC-UG-U-GAA--ACU--UC GAC--------------------------------------------------------- ----------------------------------GCUA--GUUGG--GGUGGAGU--CG- UUGU-UGAAAUA-CCACUCUGAUUGU-AUUGAACAUCUAA-CCUCG--AA--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UAUAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-UUU-AGGGA -CAG-UGCCUGGCGGGUAGUUUAACUGGGGCGGU-UGCCUCCUA-AAAUGUAAC-GGAGG CGCCCAAAGGUUCCCUCAACCUGGUCGGUAAUCAGGUGGC-GAGUGU-AAAUGCACAA-G GGGGCUUGACUG-CGAGACCU-A----CACGUCAAGCAGGGACGAAAGUCGGGAUU-AGU G-AUCCGGCA-------------------------C---------CUCUG--AGU-GGA- -----------------------------AGGGGUGUCGCUCAACGGAUAAAAGGUACCC CGGGGA-UAACAGGCUGAUCUUCCCCAAGAGUCCAUAUCGACGGGAUGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGAAGCAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCUCUAUCCGCCG --CGC--G-CGU------------------------------------------------ -----CAGAAAC-UUGAGGAAAU--CUGUCCCUAGUACGAGAGGACCGGGACGGACGAAC CUC-UGGUAUA-CCAGU-UGUCUCACCAGGGGC-AC--CGCUGGAUAGCCA-C-GUUCGG ACA-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACC------UUC-UCCAAGA--- --UCAGGUU---------------------------UC--UUA--------CC-C--A-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUG------------------------------ --------G-UGGG--A-U--AAGGCC---CCCC--G-CAGAACACGG-GA-UUGAUAGG UCAGA-CCUAGAAG-CUC-A-------------------------GUAA----------- --UGAGU--G--UAGGG-----AACU----G-GCACUAA-CUGGCC-GA---AAG-CUUA -CAAAA-- >Neisseria_gonorrhoeae -------------------AGUGCAUCA-GGCGGAUG-CCU-UGGCG-AUG-A--UAGGC GACGAAGGACGUGUA-AGCCUGCGAAAAGCGCGGGGGAGCUGGCAAUAA-AGCAAU-GAU CCCGCGGUGUCCGAAUGGGGAAACCCACUGCAUUCU------------------------ ---------------GU------------------------------------------- ------------------------------------GCAGUA-------------UCC-U AAGUU--------------------------GAAUACAU-A------------------- ---------------GGCUUAGAGAAGCGA-ACCCGGAGAACUGAACCAUCUAAGUACCC --GGAGGAAAAGAAAUCAA-CCGAGAUUCCGCAAGU-AGU-GGCGAGCGAACGCGG-AGG AGCCUGU--ACGUAA-----------------------------UAACU----------- ------------------------------------------------------------ -------------------G-------U-----CGAGGUAG------AAG-AACA--AGC UG-GG-------AAGCU------U-GACC-AUAGCGGGUGACAGUCCCGUAUUCGAAAUC -U-CAA-CA---------G-C----GGUACUAAGCGUACGAAAAGUAGGGCGGGACACGU GAAAUCCUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCA-UC-AUCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAACAGAACCUGAAACCUGAUGCAUA-CAA-ACAGU-GGGAGCGC-C----------CU A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G----UGG--------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAA CGACUUAC-A----UUCAGUAGCGA---GCUUAA-CCG--------------GAU----- ---------AGG-G-G-A-GGCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------AU------------------ ------------------------GAGUUGCUGGGUGUA-GACCCGAAACCGA-GUGAUC UAUCCAUGGCCAGGUUGAAGGUGCC-GUAACAG-GUACUGGAGGACCGA--ACCC-ACGC -AUGUUGCAAAAUGCGGGGAUGAGCUGUGGGUAGGGGUGAAAGGCUAAACAAACUCGG-A GAUAGCUGGUUCUCCCCGAAAACUAUUUAGGUAGUGCCUCGAG-C--------------- ------------------------------------------------------------ -------------------AAGAC-AC-UGAUGGGGGUAAAGC-ACUGUUAUGG--CU-A GG--G-GGU-U-AUUGC-AACUUA-CCAACCCAUGGCAAACUCAGAAUACCAU-CAA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------GU--UC--C-UCGGG-AGA-CAG-ACA--GC-GGGUGCUAACGUCCGU-UG -UCAAGA-GGGAA----ACA--ACCCAGACCGCC-GGCUAAG--GUCCC--AAAUGA--U A-G-AU-U-AAG--UGGUA-----------AACGAAGUGGGAAGGCACAGACAGCCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCUC-A-AAUCU---AUA--------ACC--G AAG-CUGCGGA--UGC---C--G----G-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- ---------------------------------CC-G-G-C-AU-GG--UAGGG----GA ---G-CGUU-CUGUAGG-------------------CU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGUG-C--A-UUGU-AA-AGU--GUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGU-U GACAU-GAGUA-GCG-A--UAA-AGCGG-G------------------UGAAAAG----- ----------CCCGCU-CGCC-GAA-AGCCC-AAGGUUUCCU-ACGCAACGUUCAUCGGC GUAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCAGAA--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-U-GA-U--UCAA-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-UGG-GG-AC--GGAG-A AGGUUA--GG--U-UG-GC-A-AGC--UGU---UGGA----AUA---GC-UUG-U-UU-- -A------AGC------CG-G------U------A---G----G---U-----G----GA A-G------A---CU-UA-G--G-----C--AAA-U-CCG-GGUUU-UC----U-UAACA -CC-G--A-GA-A--G--U-G--A-UG-A-CGA--GU-GUC------------------- ---------UA-CG--------------------------------GA-CAC--GAA--G CA-A----CC-GAUAC-CACG---CUUC-CAGGAAA-A-G-CCAC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UU-U-GAA--UC-G-AACCGUACCGCAAACCGACACAGGUGGGCA-GGA-UGAGAA -U-UCUAAGG-CG-CU-UGAG-AGAACUCG-GGAGAAGGAACUCGGCAAAU-UGAUACCG UAACUUCGGG-AGAAGGUAUGC-CC-UC--U-AA-GGUUAAG-GA-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ UU-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CUC-CGU----- A-----AGC-C-C--C-GGAGG-GUCGCAGAGAAUAGGUGGCUGCGA-----CUGUUUAU UAAAAACACAGCACUCUGC-CAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAAGAUGU----------GCA A------------GCAUCGGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCU-CC-CGA-GACUCAGCGAAGUUGAAGU-GGUUGUGAA GAUGCAAUCUACCCGCUGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUGUAGCUUUGC AUUGGACUUUGAAGUCACUUGUGUAGGAU-AGGUGGGAG-GC-U--UGGAA--GCA--GA GAC--------------------------------------------------------- ----------------------------------GCCA--GUCUC--UGUGGAGU--CG- UCCU-UGAAAUA-CCACCCUGGUGUC-UUUGAGGUUCUAA-CCCAG--AC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-CAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-GGGGA -CCG-UGCAUGGUAGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGCGUAAC-GGAGG AGUUCGAAGGUUACCUAGGUCCGGUCGGAAAUCGGACUGA-UAGUGC-AAUGGCAAAA-G GUAGCUUAACUG-CGAGACCG-A----CAAGUCGGGCAGGUGCGAAAGCAGGACAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUUCCGCCCAAGAGUUCAUAUCGACGGCGGAGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGUAGUCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCAG --UGG--G-CGU------------------------------------------------ -----UGGAAGU-UUGACGGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUA-CCGGU-UGUAACGCCAGUUGC-AU--AGCCGGGUAGCUA-A-GUUCGG AAG-AGAUAAGCGCUGAAAGCAUC--U-AAGCGCGAAACU------CGC-CUGAAGA--- --UGAGACU---------------------------UC--CCU--------UG-C--G-- G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUAA---------------------------- --------C-CGCA-CUAA---AGGGU---CGUU--C-GAGACCAGGA-CG-UUGAUAGG UGGGG-UGUGGAAG-CGC-G-------------------------GUAA----------- --CGCGU--G--AAGCU-----AACC----C-AUACUAA-UUGCCC-GUG---AGGCUUG -ACUCU-- >Nitrosomonas_europaea --GAUCAAGU---GA-AUAAGUGCAUGU-GGUGGAUG-CCU-UGGCG-AUU-A--CAGGC GAUGAAGGACGUGGA-AGCCUGCGAAAAGCUUCGGGGAGCUGGCAAACA-AGCUUU-GAU CCGGAGAUGUCCGAAUGGGAAAACCCACCC-GUAA------------------------- ------------------------------------------------------------ ------------------------------------GGGU-A-------------AUC-A CUCCU--------------------------GAAUAUAU-A------------------- ---------------GGGAGAUGAUGGCUA-ACCUGGAGAACUGAAACAUCUAAGUAACC --AGAGGAAAAGAAAUCAA-CAGAGAUUCCCAGAGU-AGU-GGCGAGCGAAAUGGG-ACC AGCCUGC--AGUUAA-----------------------------UAAUA----------- ------------------------------------------------------------ -------------------U-------U-----UAGACUAA------CCG-AAUU--AUC UG-GA-------AAGUU------A-AACC-GUAGUGGGUGAUAGUCCCGUAGGUGAAAGU -C-UGA-AU---------G-U----GGAACUAAGAUUGCAAUAAGUAGGGCGGGGCACGU GUAAUCCUGUCUGAAUAUAGGGGGACCA--UCCUCUAAGGCUAAAUACUCG-UA-AUCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAUCCUGAAACCGCAUGCAUA-CAA-ACAGU-AGGAGCC-------------UU GA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------AAGA------------------GGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-A----UUCAGUAGCGA---GCUUAA-CCG---------------AU----- ---------AGG-G-G-A-GGCGUAGUGAAA-ACG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------AU------------------ ------------------------AAGUUGCUGGGUGUA-GACCCGAAACCAG-AUGAUC UACUCAUGGCCAGGAUGAAAGGAGG-GUAAUGC-CUCGUGGAGGUCCGA--ACCC-ACUA -AUGUUGAAAAAUUAGGGGAUGAGCUGUGGGUAGGGGUGAAAGGCUAAACAAAUCUGG-A AAUAGCUGGUUCUCUCCGAAAACUAUUUAGGUAGUGCCUCAUA-U--------------- ------------------------------------------------------------ ---------------------AUU-AC-CUUUGGGGGUAGAGC-ACUGUUAUGG--CU-A GG--G-GGU-C-GUCAA-GAUUUA-CCAAACCAUUGCAAACUCCGAAUACCAA-AGA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------CA--AG--U-AUGGG-AGA-CAG-ACA--UC-GGGUGCUAACGUUCGG-UG -UCGAAA-GGGAA----ACA--ACCCAGACCUUC-AGCUAAG--GUCCC--AAAGAU--A C-A-GU-U-AAG--UGGUA-----------AACGAAGUGGGAAGGCAUAGACAGUCAGGA AGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAAUAGCUCACUGAUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCU--A-AACUG---UAC--------ACC--G AAG-CUAAGGA--UUU---G--C----AA-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UU-A----------------------------- -------------------------------AUUG-C-A-A-GU-GG--UAGGA----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUA-A--C-UUGU-GA-AGG--UUGC-U-GGA-GGUAUC-G--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--UAA-AGGAA-G------------------UGAAAAG----- ----------CUUCCU-CGCC-GAA-AACCC-AAGGUUUCCU-GUGCAACGUUCAUCGGC GCAGGG------------UUAGUCGGUCC-C-UAA----GGUG-A-GGUAGAA--AUACG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CU---GA--U-GGGA-AAC-UGG--U UAA----UAUU-CCA----GUACC-U-UU-A--UUUA-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-UGG-GG-AC--GAAG-A AGGCUA--GC--U-UA-GC-C-GGG--UGU---UGGA----UGU---CC-CGG-U-UG-- -A------AGC------AG-G------U------A---G----A---C-----A----UG C-U------A---UU-UA-G--G-----C--AAA-U-CCG-GAUAG-CU------UA--G -UC-G--A-GA-U--G--U-G--A-UA-A-CGA-AAC-CUCU------------------ ---------UU-CG-----------------------------G--GA-GGC--CAA--G UA-A----GU-AAUGC-CAUG---CUUC-CAGGAAA-A-G-CCAC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UU-A-AAU--AA-A-GACCGUACCGUAAACCGACACAGGUGGGUG-GGA-UGAGAA -U-UCUAAGG-CG-CU-UGAG-AGAACUCA-GGAGAAGGAACUCGGCAAAU-UGACACCG UAACUUCGGG-AGAAGGUGUGC-CU-CU-AG-UA-UGUGUAG-UG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ UACAC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCA-U-G----- A-----AGC-A-G--A-AUGAG-GUUGCAAAGAAAUGGUGGCUGCGA-----CUGUUUAA UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGUGAUGGGGU----------GCA A------------GCUCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCU-CC-UGA-GACUCAGCGAAGUUGAAAU-GUUUGUGAA GAUGCAAUCUACCCGCGGCUAGACGGAAAGA-CCCCGUGCACC-UUUACUGUAGCUUUAC AUUGGAUUUUGAUUAUUCUUGUGUAGGAU-AGGUGGGAG-GC-UG-U-GAA--AUA--UG CUC--------------------------------------------------------- ----------------------------------GCCA--GAGUG--UAUGGAGC--CA- ACCU-UGAAAUA-CCACCCUGGAAUG-AUCGGAGUUCUAA-CCCAG--GU--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-AUC-GGGGA -CCG-UGUAUGGUAGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGUGCGAAGGUACGCUAGGUACGGUCGGAAAUCGUACUGA-UAGUGC-AAUGGCAUAA-G CGUGCUUAACUG-CGAGACUG-A----CAAGUCGAGCAGAUGCGAAAGCAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUUCCUCCCAAGAGUUCAUAUCGACGGGGGAGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGUAGUCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAAAU-UUGAGUGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGCAC CUC-UGGUGUA-CCGGU-UAUGACGCCAGUCGU-AU--CGCCGGGUAGCUA-A-GUGCGG AAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------UGC-CAUAAGA--- --UUAGAUU---------------------------UC--CC---------GG-G--A-- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUAA---------------------------- --------U-UCCC-CUAA---AGGUU---CGUU--G-AAGACUACAA-CG-UUGAUAGG UCGAA-UGUGUAAG-CGU-A-------------------------GUAA----------- --UGCGU--U--AAGCU-----AAUC----G-AUACUAA-UUGACC-GU--GAGG-CUUG -AUCCU-- >Novosphingobium_aromaticivorans ---------U---GAGGUAAGAGCAUUU-GGUGGAUG-CCU-UGGCA-UGU-A--CAGGC GAUGAAGGACGUGGC-ACGCUGCGAUAAGCGUCGGGGAGUUGUGAG-CA-AACUUU-GAU CCGGCGAUUUCCGAAUGGGGAAACCCACCUUCACCAUUU----------------CUC-- --------UCGAG--UUGCGAG-----UG------------------------------- ----AUCGUG-----AUU-----------------UGAGUGAGGUGGAUAAGGUAUCC-C AGAUU--------------------------GAAUACAU-A------------------- ---------------GAUCUGGUGAAGCGA-ACCCGGGGAACUGAAACAUCUCAGUACCU --GGAGGAAAAGACAUCAA-CCGAGAUUCCGUUAGU-AGU-GGCGAGCGAACGCGG-ACC AGGCCAGU-GC-CUC------------------------------AU-C----------- ------------------------------------------------------------ -------------------U-------------UCAACUAG------CAG-AACA--CUU UG-GA-------AAGAG------U-GGCC-AUAGCGGGUGACAGCCCCGUAUGCGAAAGU -G-A-U-GG---------A---------UGAG-----GACUCGAGUAGGGCGGGACACGU GAAAUCCUGUCUGAACAUGGGGGGACCA--CCCUCCAAGCCUAAAUACUCG-UA-CAUGA CCGAUAGC-GAACACAGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGAUGAGGGGAGU GAAACAGUACCUGAAACCGAAUGCUUA-CAA-GCAGU-UGGAGCCUCU-----------U U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AGGG---------------GGUGACAGCGUACCUCUUGCAUAAUGGGUCAG UGACUUAG-U----UUAUCGAGCAA---GCUUAA-GCC--------------GUUA---- ---------GGU-G-U-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------CUG------------------ ------------------------AAGUUCGAUGAAUUA-GACCCGAAACCCG-GUGAUC UAGGCAUGACCAGGCUGAAGGUGCG-GUAACAC-GCACUGGAGGGCCGA--ACCG-UUGA -AUGUUGAAAAAUUCUCGGAUGAGUUGUGUUUAGGGGUGAAAGGCCAAUCAAACCGGG-A AAUAGCUGGUUCUCCGCGAAAUCUAUUGAGGUAGAGCGUCGAA-U--------------- ------------------------------------------------------------ --------------------GUAU-GC-CUCUGGGGGUAGAGC-ACUGGAUGGA--UG-C GG--G-GGU-C-GCGA--GAUCUA-CCAAUUCUAACCAAACUCCGAAUACCAG-AGA-G- A-C--------------------------------------------------------- ------------------------------------------------------------ ----------U--UG--U-UCGGC-AGA-CAG-ACG--GC-GGGUGCUAAGGUCCGU-CG -UCAAAA-GGGAA----ACA--GCCCUAACCUAC-AGCUAAG--GUCCC--CAAGUC--A U-C-AC-U-AAG--UGGGA-----------AAGCAUGUGGGAAUCCCAAAACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAACAGCUCACUGGUCUAAACA AGGGUUCCUGCGGCGAAGAUGUAACGGGGCUA-A-AGUGA---UGC--------ACC--G AAG-CUUAGGG--UGUG--A--U----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUCG----------------------------- ---------------------------------GA-UCA-C-GC-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGCGG-U--C-UGGU-AA-UGG--GCCG-U-GGA-GGUAUC-G--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--CAA-AGAGG-G------------------UGAGAUG----- ----------CCCUCU-CGCC-GAA-AGACC-AAGGGUUCCU-GCUUAAAGCUAAUCUGA GCAGGG------------UGAGCCGGCCC-C-UAA----GACG-A-GCCCGAA--GGGGG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-ACG--U UAA----UAUU-CGU----GGGCC-U-GG-U--GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------UG-UGU--G-AC--GGAU-C ACGUGU--GU--U-GU-CU-G-GCC-UUAU---UGG-----AUU---GG-UCA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GC-U----UC----GAAG-UG---GUUC-CAGGAAA-U-A-GCCC---C--A-------- ------------------------------------------------------------ ---------CCG--UAUA-GACCGUACCCGAAACCGACACAGGUGGUCA-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAAGUAU-CCUGAAGGAACUCGGCAAAU-UGCCUCCG UACCUUCGGA-AGAAGGAGGCC-CA-AC-----------CUG-UG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCA-C-U----- U-----------------GUUG-GGGGCACAGGCCAGGGGGUAGCGA-----CUGUUUAG CAAAAACACAGGACUCUGC-UAAGUC--GGCUUCAA------------GACGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-CGAAGGUUAAGAGGAGGAGU----------GCA A------------GCUCCGAAUUGAAGCCCGA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--ACUGUCUCCA-GG-AUA-UGCUCAGCGAAAUUGAAUU-CUCCGUGAA GAUGCGGAGUACCCGCGGUUAGACGGAAAGA-CCCCGUGCACC-UUUACUGCAGCUUCAG AGUGGCAUUAGGAAAGAAUUGUGUAGCAU-AGGUGGGAG-GC-UU-U-GAA--GCA--CC GGC--------------------------------------------------------- ----------------------------------GCCA--GCUGG--UGUGGAGC--CA- UAGG-UGAAAUA-CCACCCUGUUGUU-UUCUGAUGUCUAA-CCCAG--GA--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-UUC-GGGGA -CCC-UCUGUGGCGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGAGUAAC-GGAGG CGCGCGAUGGUAGGCUCAGGCCGGUUGGAAACCGGCUGUUAGAGUGC-AAUGGCAUAA-G CCUGCCUGACUG-CGAGACUG-A----CGAGUCGAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCU--CGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUGAUUCCCAAGAGCUCAUAUCGACGGAAUCGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGUGGUACGUGAGCUGGGUUCAGAACGUCGCGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----C-GAUAC-UUGAGAGGAG--UUGCCCCUAGUACGAGAGGACCGGGGUGAACAUGC CUC-UGGUGUA-CCUGU-CGUUCCGCCAGGAGC-GC--AGCAGGGUAGCUA-U-GCAUGG ACG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UCC-CUCAAGA--- --UAAGGUA---------------------------UC---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------A--UCGAGU---CGUG--G-UAGACCACCA-CG-UUGAUAGG CCGGG-UGUGGAAG-UGC-G-------------------------GUAA----------- --CGCAU--G--AAGCU-----AACC----G-GUCCUAA-UAACUC-UG--UUCA-UGCU --U----- >Oceanobacillus_iheyensis --AGUUAAGU---G-AAUAAGGGCGCAC-GGUGGAUG-CCU-UGGCA-CUA-G--GAGCU GACGAAGGACGGGAC-UAACACCGAUAUGCCUCGGGGAGUUGUAAG-UA-AACUU-UGAU CCGGGGAUUUCCGAAUGGGGAAACCCACUGUU-CGUA----------------------- ---------------AU------------------------------------------- ---------------------------------GGAGCAGUA-------------CCU-A UACCU--------------------------CAAUACAU-A------------------- ---------------GGGUAUAGGGAGCAGA-CCCGGGGAACUGAAACAUCUCAGUACCU --GGAGGAAGAGAAAGAAA-CCUCGAUUUCCUGAGU-AGC-GGCGAGCGAAACGGAA-AG AGCCCAAA-CCAGAAA--GC-----------UU-----------G---CUUUCUGGGG-- -------------------------UUGUAGGACACUCCU-------------------- -----UUGGAGUUACAAAGA--------A---AUUCUUUAA------AUG-AAUCG-AUC UG-GA-------AAGGU------C-AGCC-AAAGAAGGUAACAGCCCUGUAAUUGAAAAG -G-AAU-UU---------CCU----CCGGAG---UGUAUCCUGAGUACGGCGGAACACGU GGAAUUCCGUCGGAAUCCGGGAGGACCA--UCUCCCAAGGCUAAAUACUCC-CU-AGUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GAAGGGGAGU GAAAUAGAACCUGAAACCGUGUGCCUA-CAA-GUAGU-CGAAGCCCGU----------UA AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAGAAUGGACCGG CGAGUUAC-G----AUCCCAUGCAA---GGUUAA-GUG-------------GAAGA---- ---------CAC-G-G-A-GCCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AAUA----------------- ------------------------UAGUAUGUGGUCGUA-GACCCGAAACCGU-GUGAUC UACCCAUGUCCAGGGUGAAGGUCAG-GUAACAC-UGACUGGAGGCCCGA--ACCC-ACGU -AUGUUGAAAAAUGCGGGGAUGAGGUGUGGGUAGGGGUGAAAUGCCAAUCGAACACGG-A GAUAGCUGGUUCUCUCCGAAAUAGCUUUAGGGCUAGCCUCAAG-AU-------------- ------------------------------------------------------------ --------------------GAUG-AG-UACUGGAGGUAGAGC-ACUGAUUGGA--CU-A GG--G-GCC-C-CUACC-GGGUUA-CCGAAUUCAGUCAAACUCCGAAUGCCAGUUA--C- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--AA--C-UUGGG-AGU-CAG-ACU--AU-GGGUGAUAAGGUUCAU-AG -UCGAAA-GGGAA----ACA--GCCCAGACCGCC-AGCUAAG--GUCCC--AAAGUA--U A-C-GU-U-AAG--UGGAA-----------AAGGAUGUGGAGUUGCCCAGACAACCAGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAGAGUGCGUAAUAGCUCACUGGUC-----G AGUGACUCUGCGCCGAAAAUGUACCGGGGCU--A-AACGU---AUC--------ACC--G AAG-CUGCGGA--UUG---U--U----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAC----------------------------- ---------------------------------GA-A-C-A-AU-GG--UAGGA----GA ---G-CGUU-CUAAG-U-------------------GC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGUCA-G--A-CCGU-GA-GGA--CUGG-U-GGA-GCGCUU-A--GAAGUGAGAAUGC-C GGUAU-GAGUA-GCG-A---AA-AAAGA-G------------------UGAGAAU----- ----------CUCUUU-CACC-GAA-UGCCU-AAGGUUUCCU-GAGGAAGGCUCGUCCUC UCAGGG------------UUAGUCGGGAC-C-UAA----GCCG-A-GGCCGAU--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGAC-AAC-AGG--U AGA----UAUU-CCU----GUACC-A-CC-UC-AUGA-U-U------------------- ----------------------------------------------------G-UUUGAG CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GCAG-U AGGAUA--AG--GAAU-GC-G-CAC--CGA---UGG-----ACGU--GU-GCG-C-CC-- -A------AGC------AG-U------G------A---G----A---A----------AG U-C------A---GA-UA-G--G-----C--AAA-U-CCG-UCUGG-CA-------AU-U -UC-A--A-GC-U--G--U-G--A-UG-G-GGA--GG-GAA------------------- ---------AU-UGA-------------------------------GU-ACC--GAA--G UU-C----CG-GAUUU-CACA---CUGC-CAAGAAA-A-G-CCUC---U--A-GUU---- -A---------------------------------------------------------- -G--AU-C-AUA--GG-U-GCCCGUACCGCAAACCGACACAGGUAGGCG-AGG-AGAGAA -U-CCUAAGG-UG-AG-CGGG-AGAACUCU-CGUUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-UC-CU--U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C AU-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GGAGGAGCCGCAGUGAAUAGGCCCAAGCGA-----CUGUUUAG CAAAAACACAGGUCUCUGC-GAAGCC--GA---A-A------------GGCGAA-GU-AU AGGGGCUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGGGGACGAGUU-AGCUC---UUU G----GAGCG-AAGCUUUGAACCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGUGCAACG AC-U--UGGGC--ACUGUCUCAA-CG-AGA-GACCCGGUGAAAUUAUACU-AUGCGUGAA GAUGCGCAUUACCCGCGACAGGACGGAAAGA-CCCCGUGGAGC-UUUACUGUAGCCUGAU AUUGAAUGUUUGUGCAGCUUGUACAGGAU-AGGUGGGAG-CCUU--U-GAA--GCG--UG AGC--------------------------------------------------------- ----------------------------------GCUA--GCUUA--CGUGGAGG--CA- CCCG-UGGGAUA-CCACCCUCGCUGU-AUGAACAUUCUAA-CCCAG--GA--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-UUC-GGAGA -CAG-UGUCAGGCGGGCAGUUUGACUGGGGCGGU-CGCCUCCCA-AAGAGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGAAUGGUUGGAAAUCAUUCGUA-GAGUGU-AAAGGCAGAA-G GGAGCUUGACUG-CGAGACCU-A----CAAGUCGAGCAGGGACGAAAGUCGGGCUU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGCUACCC CGGGGA-UAACAGGCUUAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --UGG--G-CGU------------------------------------------------ -----UGGAAGU-UUGAGAGGAG--CUGUCCUUAGUACGAGAGGACCGGGAUGGACACAC CGC-UGGUGUA-CCAGU-UGUUCCGCCAGGAGC-AU--GGCUGGGUAGCUA-C-GUGUGG UAA-GGAUAAGUGCUGAAAGCAUC--U-AAGCAUGAAGCC------CCC-CUCAAGA--- --UGAAACU---------------------------UC--CCA--------UC-A--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUCGA---------------------------- ----------GUGA---GU--AAGAUC---CCUC--A-GAGACGAUGA-GG-UUGAUAGG UCCGA-GGUGGAAG-CGU-G-------------------------GCGA----------- --CACGU--G--CAGCU-----GACG----G-AUACUAA-UUGAUC-GA---GGA-CUUA -UCUAA-- >Photorhabdus_luminescens --GGUUAAGC---GA-CUAAGCGUACAC-GGUGGAUG-CCU-AGGCA-GUC-A--GAGGC GAUGAAGGACGUGCU-AAUCUGCGAAAAGCGUCGGUGAGCUGAUAUGAA-GCGACA-GAG CCGGCGAUGUCCGAAUGGGGAAACCCAGUGCAAUG------------------CG----- ---------------UU------------------------------------------- -----------------------------------GC-ACUA-------------UCA-U UAACU--------------------------GAAUUCAU-A------------------- ---------------GGUUA-AUGAGGCGA-ACCGGGGGAACUGAAACAUCUCAGUACCC --CGAGGAAAAGAAAUCAA-CCGAGAUUCCCCCAGU-AGC-GGCGAGCGAACGGGG-AGG AGCCCA-G-AACCUGC-AU-------------------------CAGCG----------- ------------------------------------------------------------ -------------------A-------U-----AGCAUCAG------AGG-AACG--GUC UG-GA-------AAGGC------C-GGCG-AGAGAGGGUGACAGCCCCGUACUCGAAGAU ---GGU-AU---------G-------GCUGUG-AGUUC-GAUGAGUAAGGCGGGACACGA GAAAUCCUGUCUGAAGGUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGGCGAGGGGAGU GAAAGAGAACCUGAAACCGUGUACGUA-CAA-GCAGU-GGGAGCCGUG----------AU ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------UAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----U------------------CAG-GGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUCUGUAGCAA---GGUUAA-CCG--------------GAU----- ---------AGG-G-G-A-GCCGCAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAC--------------- -------------------------------------------U-GGGCG---------- ----------------------------------------AAA----------------- ------------------------GAGUUGCAGGGUAUA-GACCCGAAACCCG-GUGAGC UAGCCAUGGGCAGGUUGAAGGUUGG-GUAACAC-UAACUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGACCUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGG-A GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUG-A--------------- ------------------------------------------------------------ --------------------AUUC-AU-CUUCGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGC-C-AUCCC-GGCUUA-CCAACCCGAUGCAAACUGCGAAUACCGA-AGA-A- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------GU--AU--C-ACGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--GAAGUC--A U-G-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCCCAGACAGCCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUGAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCU--A-AACCA---UGC--------ACC--G AAG-CUGCGGC--AGU---G--A----CA-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- -------------------------------GUGU-U-A-U-UG-GG--UAGGG----GA ---G-CGUU-CUGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GAGA AGGUG-G-AG-CUGU-GA-GGC--CUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-AAGUA-ACG-A--UAA-AGCGG-G------------------UGAAAAA----- ----------CCCGCU-CGCC-GGA-AGACC-AAGGGUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UGAGUCGACCC-C-UAA----GGUG-A-GGCCGAG--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CU---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-G-AA-U--GUGA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------AG-GGG-GG-AC--GGAG-A AGGCUA--GG--C-CA-UC-C-GGG--CGA---CGG-----UUGU--CC-CGG-U-UU-- -A------AGC------GU-G------U------A---G----G---U-----G----GG A-G------G---AG-CA-G--G-----U--AAA-U-CCG-CUCUU-CU----GUGAACA -CU-G--A-GG-C--G--U-G--A-UG-A-CGA--GC-CGU------------------- ---------UA-CG--------------------------------GC-GGU--GAA--G UG-G----UU-GAUGC-CCGG---CUUC-CAGGAAA-A-G-CCUC---U--A-AGC-CU- CA---------------------------------------------------------- -G--GU-C-AUA--UU-G-AAUCGUACCCCAAACCGACACAGGUGGUCA-GGU-AGAGAA -U-ACUCAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UGGUGCCG UAACUUCGGG-AGAAGGCACGC-UG-GC-GG-UA-GGUGAAG-GG-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CUC-C-G----- G-----AGC-U-G--A-AGCCA-GUCGCAGAGACCAGCUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUGUGC-AAACAC--GU---A-A------------GUGGAC-GU-AU ACGGUGUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAUUGAUGGGGUU-AGCC----GCA A-----GGCG-AGGCUCUUGACAGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAG--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAACU-CGCUGUGAA GAUGCAGUGUCCCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGAC ACUGAACAUGGAGCCUUGAUGUGUAGGAU-AGGUGGGAG-GCUG--A-GAA--GUG--CG GAC--------------------------------------------------------- ----------------------------------GCCA--GUCUG--CAUGGAGC--CA- UCCU-UGAAAUA-CCACCCUUGAAUG-UUCGAUGUUCUCA-CCUGG--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GCC-GGGGA -CAG-UGUCUGGCGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGGGUAAC-GGAGG AGCACGAAGGUUGGCUAAUCACGGUCGGACAUCGUGAGGU-UAGUGC-AAAGGCAUAA-G CCAGCUUAACUG-CGAGAGUG-A----CGGUUCGAGCAGGUACGAAAGUAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGUAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGC------------------------------------------------ -----AGGAAGA-UUGAAAGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGCAC CGC-UGGUGUA-CGGGU-UGUCAUGCCAAUGGC-AU--AGCCCGGUAGCUA-A-GUGCGG GAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------UGC-CUUGAGA--- --UGAGUCU---------------------------UC--CCC--------UG----A-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGAG---------------------------- --------G-U-CA-CGGA---AGGAA---CGUU--U-AAGACGAAGA-CG-UGGAUAGG CUGGG-UGUGUAAG-UGC-A-------------------------GCGA----------- --UGCAU--U--GAGCU-----GACC----A-GUACUAA-UGAACC-GA--GAGG-CUUA -ACCUU-- >Polaromonas_sp. --GGUCAAGU---GA-AUAAGAGCACAU-GGUGGAUG-CCU-UGGCA-AUG-A--UAGGC GACGAAAGACGUGAU-AGCCUGCGAUAAGCUUCGGGGAGCUGGCAAAUU-AGCUUU-GAU CCGGAGAUUUCUGAAUGGGGAAACCCACCC--UUC------------------------- ------------------------------------------------------------ ------------------------------------GGGGUA-------------UCG-C AUACU--------------------------GAAUACAU-A------------------- ---------------GGUAU-GCGAGGCGA-ACCGGGUGAACUGAAACAUCUCAGUAGCU --CGAGGAAAAUACAUCAA-CCGAGAUUCCGAAAGU-AGU-GGCGAGCGAAAUCGG-AGA AGCCUGU--UAGUGA-----------------------------UAGCA----------- ------------------------------------------------------------ -------------------A-------G-----ACUCUUAG------CAG-AACA--GCC UG-GA-------AAGGC------U-GGCC-AUAGCGGGUGAUAGCCCCGUAUGCAAAAAG -A-GAC-UU---------G-U----GGUACUGAGCUAACGAAAAGUAGGGCGGGACACGA GAAAUCCUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCA-UC-AUUGA CCGAUAGU-GAACU-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAUCCUGAAACCGUGUGCUUA-CAA-AAAGU-AGGAGCC-------------UC GC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-A----UUCAGUGGCAA---GGUUAA-CCG--------------AAU----- ---------AGG-G-U-A-GCCGUAGAGAAA-UCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------A-U------------------ ------------------------CAGUCGCUGGGUGUA-GACCCGAAACCAA-GUGAGC UAUCCAUGGCCAGGAUGAAGGUGCG-GUAACAC-GCACUGGAGGUCCGA--ACCG-ACUA -GUGUUGCAAAACUAGCGGAUGAGCUGUGGAUAGGGGUGAAAGGCUAAACAAACUUGG-A AAUAGCUGGUUCUCUCCGAAAACUAUUUAGGUAGUGCCUCAAG-U--------------- ------------------------------------------------------------ ---------------------AUU-AC-CGUCGGGGGUAGAGC-ACUGUUUUGG--CU-A GG--G-GGU-C-AUGGC-GACUUA-CCAAACCAAUGCAAACUCCGAAUACCGA-CGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ---------C---AG--C-UUGGG-AGA-CAG-AGC-ACC-GGGUGCUAACGUCCGG-AC -UCAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--UAAA-A--U U-G-GC-U-AAG--UGGGA-----------AACGAAGUGGGAAGGCUAUAACAGUCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUGAUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCU--A-AGCCA---GUU--------ACC--G AAG-CUGCGGA--UUU---G--C----AA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- --------------------------------UUG-C-A-A-GU-GG--UAGGA----GA ---G-CGUU-CUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUG-U--G-GUGU-AA-ACC--CUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-U--UAA-AGGGG-G------------------UGAAAAG----- ----------CCCCCU-CGCC-GUA-AGCGC-AAGGUUUUCU-ACGCAACGUUCAUCGGC GUAGAG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCAGAG--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CU---GA--U-GGGA-AAC-AGG--U CAA----UAUU-CCU----GUACC-G-AU-G--UGUA-G-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-UGG-GG-AC--GGAG-A AGGUUA--AC--U-CA-GC-C-AAC--UGU---UGGA----UAU---GU-UGG-U-UC-- -A------AGC------CU-G------U------A---G----U---C-----G----UG C-C------U---GG-UA-G--G-----U--AAA-U-CCG-CCGGG-CU------UA--G -AU-G--A-GG-G--G--U-G--A-UA-A-CGA--GU-CUG------------------- ---------CU-UG--------------------------------CA-GAC--GAA--G UG-A----GU-GAUAC-CCUG---CUUC-CAGGAAA-A-G-CCAC---U--A-AGC-UU- CA---------------------------------------------------------- -G--CU-A-CAC--A--C-GACCGUACCGCAAACCGACACUGGUGCGCG-AGA-UGAGUA -U-UCUAAGG-CG-CU-UGAG-AGAACUCA-GGAGAAGGAACUCGGCAAAU-UGACACCG UAACUUCGGA-AGAAGGUGUGC-CU-UU-AG-UA-GGUGAAC-CA-U------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U U--AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UUG-G-G----- G-----AGC-C-C--A-AUGAG-GCUGCAAAAAAUCGGUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUCUGC-UAAGAC--GA---A-A------------GUCGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-U-GGAAGAUUAAAUGAUGGGGU----------GCA A------------GCUCUUGAUUGAAGUCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAC--ACUGUCUCCU-CC-UGA-GACUCAGCGAAGUUGAAAU-GUUUGUGAU GAUGCAAUCUCCCCGCGGAAAGACGGAAAGA-CCCCAUGAACC-UUUACUGUAGCUUUGU AUUGGACUUUGAACAGAUCUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GCC--CG GUC--------------------------------------------------------- ----------------------------------GCUA--GAUCG--GGUGGAGC--CA- ACGU-UGAAAUA-CCACCCUGGUGUG-UUUGAGGUUCUAA-CCUAG--GU--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-AUC-GGGGA -CAG-UGCAUGGUAGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGUGUAAC-GGAGG AGUUCGAAGGUACGCUAGGUACGGUCGGACAUCGUGCUAA-UAGUGC-AAUGGCAUAA-G CGUGCUUAACUG-CGAGACUG-A----CAAGUCGAGCAGAUGCGAAAGCAGGACAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCUCAUCCUGGGGCUGUAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGAGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUUCCG --UGG--G-CGC------------------------------------------------ -----UGCAGAU-UUGAGGAAGC--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUA-CCGGU-UGUCACGCCAGUGGC-AU--UGCCGGGUAGCUA-A-GUUCGG AAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------CGU-UUCAAGA--- --UUAGAUC---------------------------UG--CC---------GG-G--G-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUUGA---------------------------- --------G-CCCC-CUGA---AGAGU---CGUU--C-AAGACCAGGA-CG-UUGAUAGG UCAGG-UGUGGAAG-CGC-A-------------------------GUAA----------- --UGCGU--U--AAGCU-----AACU----G-AUACUAA-UUGCUC-GU--GCGG-CUUG -ACCCU-- >Porphyromonas_gingivalis ------------------AAGGGCAGAC-GGUGGAUG-CCU-AGGCU-CUC-G--GAGGC GAAGAAGGACGUGAU-AAGCUGCGAAAAGCUGCGGGAAUCGGCACA-UA-CGAAUU-GAU CCGCAGAUAUCCGAAUGGGGCAACCCGUCAGGCCA-A-------------G--------- ------------------------------------------------------------ -------------G---------------------CCUGACA--------------CA-U GAAUU--------------------------G-AUU------------------------ ------------------UCAU--GAGCGA-ACGCGGGGAACUGAAACAUCUCAUUACCC --GUAGGAGAAGAAAACAA-AAGUGAUUCCCUCAGU-AGU-GGCGAGCGAACGGGG-AUU AGCCCAAA-CC-GGCU-UUGUUU---------------------CGGCAAAGUCGGGG-- -------------------------UAAUAGGACUUCGA------C--------AAAAG- --UUUA------------AU-------GA---UAGAUAUAG------GAG-AACC--UAC UG-GA-------AAGUA------U-GGCC-GAAGAGCAUGAAAGCUGCGUAUCCGACAUA -U-CGA-AC---------AAU----AGACG-ACGGAGCACCUGAGUAGCGCGGGACACGA GACAUCCUGUGUGAAUUGGCGGGGCCCA--UCCCGUAAGGCUAAAUACUCC-CG-AGAGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CUCGAACAGAGGAGU GCAAUAGACCCUGAACCCGUCUGCCUA-CAA-GCGGU-AGGAGCGCCA-----------U U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACUGCGUGCCUUUUGCAUAAUGAACCUA CGAGUUAC-U----GUUUGUGGCAA---GGUUAA-UUG--U-UAU------AAUCA---- ------AGACAA-G-G-A-GCCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAA--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------CCCAUU--------------- ------------------------UAGUCACGAGCAGUA-GACGCGAAACCAA-GUGAUC UACCCUUGGUCAGGUUGAAGGUUAG-GUAACAC-UAACUGGAGGACCGA--AUCG-GUAA -GCGUUGAAAAGCUUUCGAAUGAACUGAGGGUAGGGGUGAAAGGCUAAUCAAACUUGG-A GAUAGCUCGUACUCCCCGAAAUGCAUUUAGGUGCAGCCUGUUG-G--------------- ------------------------------------------------------------ --------------------AU-G-UU-AUCAUGAGGUAGAGCGACUGAUUGGA--UG-C GA--G-GGU-U-UCAC--CGCCUA-UCAAGUCCAGAUAAACUCCGAAUGCAUG-AU--A- AUU--------------------------------------------------------- ------------------------------------------------------------ ---------G---AC--C-GAUGG-AGU-GAG-GGC--AU-GGGUGCUAAGGUCCAU-GU -CCGAGA-GGAGA----AGA--AUCCGGACCACC-GGCUAAG--GUCCC--GAAAUA--A U-U-GC-U-AAG--UUGUA-AA--------AACGAAGUCAAGAUGCAGAGACAGCUAGGA UGUUGGCUUGG-AAGCAGCCAUUCAUUUAAAGAGUGCGUAACAGCUCACUAGUC-----G AGGAUUUUGGCAUGGAUAAUA-CACGGGCAU--A-AGCAA---UUU--------ACC--G AAG-CCGUGGG--AUA---U--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ----------------------------------U-A-U-A-UC-GG--UAGGG----GA ---G-CAUU-CCAGCGAC------------------GU-A-------------------- ------------------------------------------------------------ ---------------------------------------------------------GAA GGGAA-A--A-GGGC-GA-CUU--UUUC-U-GGA-GUUUCU-G--GAAAAGCAAAUGU-A GGUAU-AAGUA-ACG-A--UAA-AGGGG-G------------------CGAGAAC----- ----------CCCCCU-CGCC-GAA-AGACC-AAGGUUUCCU-GAUCAACGCUAAUCGGA UCAGGG------------UUAGUCGGGGC-C-UAA----GGAU-A-AGCCGAA--UGGCG ---------------------------A-U-U---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--U-GGAAGAAC-CGG--U UAA----UAUU-CCG----GUACU-G-AU-A--CAGA-G-A------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-UGG-UG-AC--GGAG-A AGUGAC--AG--U-CCGGC-C-GUC--UGA---CGGA----AUA---GG-CGG-U-UA-- -A------AGG------GU-G------U-A--GAU---G----U---U-----G----AU C-G------G---GG-UA-G--G-----C--AAA-U-CCG-CCCUG-AG------A---G -UC-G--A--A-C--C--U-G--A-CA-G--UA--CC-CGGA-GUA-------------- ---------CA-AG-------------------------UAC-G--AA-GGG-AUA---- AG-G----AC-GUAAA-CCGG---CUCC-CAAGAAA-A-C-CCGC---U--A-AGC-AU- -A---------------------------------------------------------- -U--UU-C-UGU--GU-U-ACCCGUACCGUAAACCGACACAGGUGGUUG-GGU-UGAGUA -U-ACUAAGG-CG-CU-CGAG-AGAUUCGC-GGUUAAGGAACUAGGCAAAA-UGGUCCUG UAACUUCGGG-AGAAAGGACGC-CU-GU--C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U CC-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GACAG-GCCGCAGAAACCAGGCCCAGGCGA-----CUGUUUAA CAAAAACACAAGGCUAUGC-AAAAAA--GC---A-A------------UUUGAG-GU-AU AUAGUCUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGGAGUC-AUC-----GUC AA-----GAG-AAGCUCUGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGUGUAACG AU-C--UGGGC--ACUGUCUCAA-CC-GCG-AUCUCGGUGAAAUUGUAGU-AUCGGUGAA GAUGCCGAUUACCCGCAACGGGACGAAAAGA-CCCCGUGAACC-UUUACUAUAGCUUUAC AUUGUAUUUGGGCAUCAGAUGUGUAGGAU-AGGCCGGAG-GC-AG-A-GAA--GCG--GG UAC--------------------------------------------------------- ----------------------------------GCCA--GUAUU--CGUGGAGU--CG- AUGU-UGAAAUA-CGGCCCUUUUGAU-GUUUGGAUACUAA-CUC-G--CG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GCG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UGC-GAGGA -CAG-UGUAUGGUGGGUAGUUUGACUGGGGUGGU-CGCCUCCAA-AAGCGUAAC-GGAGG CUUCUAAAGGUACCCUCAGGCCGAUUGGUAACCGGUCGCA-GAGUGU-AAUGGCACAA-G GGUGCUUGACUG-GGAGACAA-A----CAAGUCGCACAGGUAGGAAACUAGAGCAU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAAAGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUCACUCCCAAGAGCUCAUAUCGACGGAGUGGUUUGGCACCUC GAUGUCGGCUCGUCACAUCCUGGGGCUGGAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGUGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCUCUAUCUGUUG --UGG--G-CGC------------------------------------------------ -----AGGAAAU-UUGCGAGGGU--CUGACACUAGUACGAGAGGACCGUGUUGGACAGAC CCC-UGGUUUA-CCGGU-UGUACCGCCAGGUGC-AC--CGCCGGGUAUCCA-C-GUCUGG UAA-GGAUAAGUGCUGAAAGCAUC--U-AAGCACGAAGCC------GGC-CUCAAGA--- --UAAGAUU---------------------------UCCAUA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AAU---AGGGU---GGUU--A-AAGACUAUGA-CC-UUGAUAGG CUGCA-GGUGUAUG-AUU---------------------------GGUA----------- --ACAAU--U--AAGCC-----GAGC----A-GUACUAA-UAGCCC-GA--AACU-UUUG -U------ >Propionibacterium_acnes ------AAGU---U-GUGUAGUGCGAUC-GGUGGAUG-CCU-UGGCA-CCA-A--GAGCC GAUGAAGGACGUUGU-GACCUGCGAUAAGCCCUGGGGAGUUGGUGAGCG-AGCUGU-GAU CCGGGGGUGUCCGAAUGGGGAAACCUGGAAUGUCCGG----------------AGUA--- ---------------GU------------------------------------------- ---------------------------------GUCCGGUGG-------------CCC-U GCCCU--------------------------GAAUGUAU-A------------------- ---------------GGG-UGUGGGUGGUA-ACGCGGGGAAGUGAAACAUCUUAGUACCC --GUAGGAAGAGAAAACAA-GUGUGAUUCCGUGAGU-AGU-GGCGAGCGAAAGCGG-AGG AGGCUAAA-CCGUGUGUGUGUUC-AAGCCG-GCAGGUG------UUGCAUGUGCGGGG-- -------------------------UUGUGGGGGCCUUGUGGUUCUGCU--GCCGCAGG- --AUUGGCCAGUGAGA--AAUG-----UU---GCGUGAAGG------UG--AAGC--GUC UG-GG-------AAGGC------G-UACC-GGAGUGGGUGAGAGUCCUGUAACUGUAAGC -G-UGG-CA---------CUG----GU--GUGGGGUUGCCCCGAGUAGCGUGGGACUCGU GGAAUUUCGCGUGAAUCUGGCGGGACCA--CCCGUCAAGCCUAAAUACUCC-UU-GGUGA CCGAUAGU-GGAUG-AGUACCGUGAGGGAAGGGUGAAA-AGUAC-CCCGG-GAGGGGAGU GAAAGAGUUCCUGAAACCGGUCGCAUG-CAA-GCCGU-CAGAGCCU-------------- GU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GU-----GGUGAUGGCGUGCCUUUUGAAGAAUGAGCCUG CGAGUUAGUG----AUGCGUGGCGA---GGUUAA-CCC--------------GUGGU--- ---------GGG-G-G-A-GUCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AUA--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------U------------------- ------------------------GAGUCGCGUGUUCUA-GACCCGAAGCGGU-GUGAUC UAUCCAUGGCCAGGAUGAAGCGUCG-GUAAGAC-GUCGUGGAGGUCCGA--ACCC-ACUU -CAGUUGAAAAUGGAGGGGAUGAGUUGUGGAUAGGGGUGAAAGGCCAAUCAAACACCG-U GAUAGCUGGUUCUCCCCGAAAUGCAUUUAGGUGCAGCGUUGCG-U--------------- ------------------------------------------------------------ --------------------GGUU-CU-UGUUGGAGGUAGAGC-ACUGGAUGGU--CU-A GG--G-GGC-U-UAUC--GGCUUA-CCGAAAUCAGCCAAACUCCGAAUGCUGG-CA--A- GUG--------------------------------------------------------- ------------------------------------------------------------ ---------U---AG--C-GUGGC-AGU-GAG-ACG--GC-GGGGGAUAAGCUUCGU-CG -UCGAGA-GGGAA----ACA--GCCCAGAUCAUC-AGCUAAG--GCCCC--UAAGUG--G U-G-AC-U-CAG--UGGGA-----------AAGGAUGUGGAGUUGCGUAGACAACCAGGA GGUUGGCUUGG-AAGCAGCCAU-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGUGAUUCCGCGCCGAUAAUGUAGCGGGGCUU-A-AGUUA---UCC--------GCC--G AAG-CUGUGGC--AAC---C---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UGUGU---------------------------- ------------------------------------G-G-U-UG-GG--UAGGG----GA ---G-CGUC-GUGU-CA-------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGCUG-C--C-GGGU-GA-CUGU-GUGG-U-GGA-GUUGAU-G--CGAGUGAGAAUGC-A GGCAU-GAGUA-GCG-U---GU-GACGG-G------------------UGGGAAU----- ----------CCCGUC-CGCC-GAU-UAUCC-AAGGGUUCCA-GGGUCAAGUUUGUCUGC CCUGGG------------UGAGUCGGGUC-C-UAA----GGCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGU-AAC-CAG--U UGA----UAUU-CUG----GUACC-G-GC-U--UGUC-A-C----C----G--UCCG-UG UCGAGGUGUGUGAUGCUAAGCAUGU-GA---GCUUGUC-UUGG---GAGUGU------UU UUG---AUGCUU-C-UGGGG--UGGGU---GA-GUGUGUGA-ACCGAUCAUGUAGUAGGC A-----AGC-U----------------------------GCG-GAG-GG-AC--GCAG-U GAGGUA--GC--U-CA-UC-C-CCGG-UGA---UGGU----UGU--CCG-GGG---CU-- -A------AGU------GU-G------U------G---G----A---C----------UG U-C------U---GG-UA-G--G-----U--AAA-U-CCG-CUGGG-CG----UGAAG-G -UU-G--A-GG-C--A--U-G--A-UG-G-GGA--GC-CCAU------------------ ---------GG-UU-----------------------------G--UG-GGU--GAG--- UG-A----GU-GAUCC-UGUA---CUGU-CGAGAAA-A-G-CUUC-GUG--A-GCG--A- G----------------------------------------------------------- -G--UG-G-CGG--GUCC-GCCCGUACCCUAAACCGACACUGGUGGAUA-GGU-AGAGUA -U-ACCGAGG-CG-AU-CGAG-UGAAUCGU-GGUGAAGGAACUCGGCAAAA-UGCCCCCG UAACUUUGGG-AUAAGGGGGAC-CU-GA--G-C--UGUCGUG-CA-CC------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C GU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------G---GUG-U-G----- G----UGGC-G----G-UGAGG-GGCGCAGAGUCCAGGGGGAAACGA-----CUGUUUAC CAAAAACACAGGUCCGUGC-GAAGUC--GU---A-A------------GACGAU-GU-AU ACGGACUG-ACUCCUGCCCGGUGC-U-GGAAGGUUAAGGGGAACUGUG-AGU-----GUA U------GCG-UAGCGGUGAACUUAAGCCCCA-G-UAAACGG-CGGUGGUAACUAUAACC AUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGAGUAACG AU-U--UCCCU--ACUGUCUCCA-CC-AUG-AACUCGGUGAAAUUGCAUU-ACGAGUAAA GAUGCUCGUUACGCGCAGCAGGACGGAAAGA-CCCCG-GGACC-UUUACUAUAGUUUGGU AUUGGUGAUUGGGACGGUUUGUGUAGGAU-AGGUGGGAG-AC-GU-U-GAU--GCG--GC CAC--------------------------------------------------------- ----------------------------------GCUA--GUGGU--GGUGGAGU--CG- UUGG-UGAAAUA-CCACUCUGAUUGU-UCUGGUUAUCUCA-CUGUG--GA--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-UUC-AAGGA -CAG-UGCCUGAUGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGGGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGCCUGGUUGGUAAUCAGGUGGU-GAGUGU-AAGUGCACAA-G GGGGCUUGACUG-UGAGACUG-A----CAGGUCGAGCAGGGACGAAAGUCGGGACU-AGU G-AUCUGACG-------------------------G---------UGGCU--UGU-GGA- -----------------------------UGCGCCGUCACUCAACGGAUAAAAGGUACCC CGGGGA-UAACAGGCUGAUCUUGCCCGAGCGCUCAUAGCGACGGCAUGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGCUG --CGC--G-CGG------------------------------------------------ -----AGGAAUC-UUGAGAAGGG--CUGUCUUUAGUACGAGAGGACCGAGACGGACUGAC CUC-UGGUGUG-CCAGU-UGUUCUGCCAAGAGC-AU--GGCUGGUUGGCUA-C-GUCGGG UUG-UGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCA------CGC-UUCAAGA--- --UAAGGGU---------------------------UC--CCA--------CA-G--G-- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUGU----------------------------- --------U-CCUG---GU--AAGGUC---CCCG--A-GAGAUGAUCG-GG-UUGAUAGG CCAGA-CGUGGACG-CAU-C-------------------------GUAA----------- --GGUGU--G--GAGCU-----GACU----G-GUACUAA-UAGA---------------- -------- >Pseudomonas_aeruginosa --GGUCAAGU---GA-AGAAGCGCAUAC-GGUGGAUG-CCU-UGGCA-GUC-A--GAGGC GAUGAAAGACGUGGU-AGCCUGCGAAAAGCUUCGGGGAGUCGGCAAACA-GACUUU-GAU CCGGAGAUCUCUGAAUGGGGGAACCCACCUAGGAU------------------AA----- ---------------CC------------------------------------------- -----------------------------------UA-GGUA-------------UCU-U GUACU--------------------------GAAUCCAU-A------------------- ---------------GGUGC-AAGAGGCGA-ACCAGGGGAACUGAAACAUCUAAGUACCC --UGAGGAAAAGAAAUCAA-CCGAGAUUCCCUUAGU-AGU-GGCGAGCGAACGGGG-AUU AGCCCU-U-AAGC--------------------------------UUCA----------- ------------------------------------------------------------ -------------------U-------U-----GAUUUUAG------CGG-AACG--CUC UG-GA-------AAGUG------C-GGCC-AUAGUGGGUGAUAGCCCCGUACGCGAAAGG ---AUC-UU---------U-------GAAGUG-AAAUC----GAGUAGGACGGAGCACGA GAAACUUUGUCUGAACAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUAC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGGAGAGGGGAGU GAAAUAGAACCUGAAACCGUAUGCGUA-CAA-GCAGU-GGGAGCCU-A----------CU U-------------------------------------GUUA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUCAGUGGCAA---GCUUAA-CCG--------------UAU----- ---------AGG-G-U-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------UAGUCGCUGGGUAUA-GACCCGAAACCGG-GCGAUC UAUCCAUGAGCAGGUUGAAGGUUAG-GUAACAC-UGACUGGAGGACCGA--ACCC-ACUC -CCGUUGAAAAGGUAGGGGAUGACUUGUGGAUCGGAGUGAAAGGCUAAUCAAGCUCGG-A GAUAGCUGGUUCUCCUCGAAAGCUAUUUAGGUAGCGCCUCAUG-U--------------- ------------------------------------------------------------ ---------------------AUC-AC-UCUGGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGU-C-AUCCC-GACUUA-CCAAACCGAUGCAAACUCCGAAUACCCA-GAA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------CC--GAG-C-AUGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAAA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--AAAGUU--G U-G-GU-U-AAG--UGGUA-----------AACGAUGUGGGAAGGCUUAGACAGCUAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCUC-A-AACCA---CAC--------ACC--G AAG-CUGCGGG--UGU---C--A----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------GU-G-A-C-GC-GG--UAGAG----GA ---G-CGUU-CUGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUG-A--G-UUGA-GA-AGC--UUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-ACG-A--CAA-UGGGU-G------------------UGAAAAA----- ----------CACCCA-CGCC-GAA-AGACC-AAGGGUUCCU-GCGCAACGUUAAUCGAC GCAGGG------------UUAGUCGGUUC-C-UAA----GGCG-A-GGCUGAA--AAGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-U-CU-G--GUUA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GAG-GG-AC--GGAG-A AGGCUA--GG--C-CA-GC-U-UGG--CGU---UGG-----UUGU--CC-AAG-U-UU-- -A------AGG------UG-G------U------A---G----G---C-----U----GA A-A------U---CU-UA-G--G-----U--AAA-U-CCG-GGGUU-UC------AAG-G -CC-G--A-GA-G--C--U-G--A-UG-A-CGA--GU-CGUCU----------------- ---------UU-UA-----------------------------G--AU-GAC--GAA--G UG-G----UU-GAUGC-CAUG---CUUC-CAAGAAA-A-G-CUUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--GU-A-ACC--AG-G-AACCGUACCCCAAACCGACACAGGUGGUCG-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UGGCACCG UAACUUCGGG-AGAAGGUGCGC-CG-GC--U-AG-GGUG-AA-GG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UCC-G-U----- A-----AGC-U-C--U-GGCUG-GUCGAAGAUACCAGGCCGCUGCGA-----CUGUUUAU UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAUGGGGUU-AGC-----GCA A------GCG-AAGCUCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCGGC--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAAAU-CGCUGUGAA GAUGCAGUGUAUCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUGUAGCUUUGC ACUGGACUUUGAGCCUGCUUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GCG--UG GAC--------------------------------------------------------- ----------------------------------GCCA--GUUCG--CGUGGAGC--CA- UCCU-UGAAAUA-CCACCCUGGCAUG-CUUGAGGUUCUAA-CUCUG--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUC-GAGGA -CAG-UGUAUGGUGGGCAGUUUGACUGGGGCGGU-CUCCUCCUA-AAGAGUAAC-GGAGG AGUACGAAGGUGCGCUCAGACCGGUCGGAAAUCGGUCGUA-GAGUAU-AAAGGCAAAA-G CGCGCUUGACUG-CGAGACAG-A----CACGUCGAGCAGGUACGAAAGUAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--A-CGU------------------------------------------------ -----UUGAGAU-UUGAGAGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUU-CCGGU-UGUCACGCCAGUGGC-AU--UGCCGGGUAGCUA-U-GUUCGG AAA-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------UGC-CUCAAGA--- --UGAGAUC---------------------------UC--ACU--------GG-G--A-- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUUGA---------------------------- --------U-UCCC-CUGA---AGGGC---CGUC--G-AAGACUACGA-CG-UUGAUAGG CUGGG-UGUGUAAG-CGU-U-------------------------GUGA----------- --GGCGU--U--GAGCU-----AACC----A-GUACUAA-UUGCCC-GU--GAGG-CUUG -ACCAU-- >Ralstonia_eutropha --GGUCAAGC---GA-ACAAGUGCAUGU-GGUGGAUG-CCU-UGGCG-AUC-A--CAGGC GAUGAAGGACGCGGU-AGCCUGCGAAAAGCUUCGGGGAGCUGGCAAACG-AGCUUU-GAU CCGGAGAUGUCCGAAUGGGGAAACCCGGCCCGAAU------------------------- ------------------------------------------------------------ ------------------------------------GGGUCA-------------UCC-C UGACU--------------------------GAAUACAU-A------------------- ---------------GGUCA--GGGAAGCGAACGCGGCGAACUGAAACAUCUAAGUAGCU --GCAGGAACAGAAAUCAA-CCGAGAUUCCCAAAGU-AGU-GGCGAACGAAAUGGG-AAG AGCCUUGU-ACUCUU-----------------------------UAGCA----------- ------------------------------------------------------------ -------------------G-------U-----GUUGUUAG------CAG-AACG--GGA UG-GA-------AAGCC------C-GGCC-GUAGCAGGUGAUAGCCCUGUAUGCGAAAAC -A-GCG-UU---------G-U----GGAACUAGGUGUACGACAAGUAGGGCGGGACACGU GAAAUCCUGUCUGAAGAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCG-UG-AUCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAUCCUGAAACCGCAUGCAUA-CAA-ACAGU-CGGAGCC-------------UC GU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-A----UUCAGUGGCGA---GCUUAA-CCG--------------AUU----- ---------AGG-G-C-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAC--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------AU------------------ ------------------------UAGUCGCUGGGUGUA-GACCCGAAACCAG-AUGAUC UAUCCAUGGCCAGGUUGAAGGUGCG-GUAACAC-GUACUGGAGGACCGA--ACCC-ACUA -ACGUUGAAAAGUUAGGGGAUGAGCUGUGGAUAGGGGUGAAAGGCUAAACAAAUCUGG-A AAUAGCUGGUUCUCUCCGAAAACUAUUUAGGUAGUGCCUCGUG-U--------------- ------------------------------------------------------------ ---------------------GUC-AC-CUUCGGGGGUAGAGC-ACUGUCAUGG--UUGG GG--G-GUC-U-AUUGC-UGAUUA-CCCCGCCAUAGCAAACUCCGAAUACCGA-AGA-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------C---AAU-C-ACGGG-AGA-CAG-ACA--UC-GGGUGCUAACGUCCGG-UG -UCAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--CAAA-U--A U-G-GC-U-AAG--UGGGA-----------AACGAAGUGGGAAGGCUAAAACAGUCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUGAUC-----G AGUCGUCCUGCGCGGAAGAUGUAACGGGGCU--A-AGCCA---UAU--------ACC--G AAG-CUGCGGA--CGC---A--C----AG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------C-AA----------------------------- ---------------------------------UG-U-G-C-GU-GG--UAGGA----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUG-U--C-UUGU-AA-AGG--AUGC-U-GGA-GGUAUC-G--GAAGUGCGAAUGC-U GACAU-GAGUA-GCG-A--UAA-AGGGG-G------------------UGAAAGG----- ----------CCCCCU-CGCC-GUA-AGCCC-AAGGUUUCCU-ACGCAACGUUCAUCGGC GUAGGG------------UGAGUCGGCCC-C-UAA----GGCG-A-GGCAGAG--AUGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CU---GA--U-GGGA-AGC-AGG--U UAA----UAUU-CCU----GCACC-G-UC-G--UAUG-A-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GGAU-C GCGGAA--GG--U-UG-UC-C-GGG--UGU---UGGA----AGU---CC-CGG-U-CC-- -C------UGC------AG-U------G------G---A----G---A----------AG G-C------G---CU-UA-G--G-----C--AAA-U-CCG-GGCGC-GU------AAU-U -CA-A--G-GC-U--G--U-G----GG-G-CGA--GU-GAG------------------- ---------CU-AGG-------------------------------CU-CGC--GAA--G CA-A----UU-GG-AA-G-UG---GUUC-CAAGAAA-A-G-CCUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--UC-A-UAC--GA---GACCGUACCGCAAACCGACACAGGUGGGCG-AGA-UGAGUA -U-UCUAAGG-CG-CU-UGAG-AGAACUCG-GGAGAAGGAACUCGGCAAAU-UGGUACCG UAACUUCGGG-AUAAGGUACGC-CC-UG-GU-AG-CUUGACU-GG-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C U--GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GCC-A-G----- A-----AGG-G-U--G-AAGGG-GUUGCAAUAAAAUGGUGGCUGCGA-----CUGUUUAA UAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGAUUAAAUGAUGGGGU----------GCA A------------GCUCUUGAUUGAAGUCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-G--GCCAC--ACUGUCUCCU-CC-CGA-GACUCAGCGAAGUUGAAGU-GUUUGUGAU GAUGCAAUCUCCCCGCGGCUAGACGGAAAGA-CCCCAUGAACC-UUUACUGUAGCUUUGC AUUGGACUUUGAACCGAUCUGUGUAGGAU-AGGUGGGAG-GC-UU-U-GAA--GCG--UG GAC--------------------------------------------------------- ----------------------------------GCUA--GUUCA--CGUGGAGC--CG- UCCU-UGAAAUA-CCACCCUGGUUUG-UUUGAGGUUCUAA-CCUUG--GC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GUC-GGGGA -CAG-UGCAUGGUAGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGUGUAAC-GGAGG AGUUCGAAGGUACGCUUGGUACGGUCGGACAUCGUACCUA-AAGUGC-AAUGGCAAAA-G CGUGCUUAACUG-CGAGACCG-A----CAAGUCGAGCAGGUGCGAAAGCAGGACAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCUCAUCCUGGGGCUGUAGCCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGAGGUACGUGAGCUGGGUUUAAAACGUCGUGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAAUC-UUGACGGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGUAC CGC-UGGUGUA-CCUGU-UGUCUCGCCAGAGGC-AU--CGCAGGGUAGCUA-U-GUACGG AAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------CGC-CUGAAGA--- --UGAGGAU---------------------------UC--CCU--------GG-A--G-- G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUUGA---------------------------- --------C-CUCC-UUGA---AGGGU---CGUU--C-GAGACCAGGA-CG-UUGAUAGG CUGGG-UGUGGAAG-CGC-A-------------------------GUAA----------- --UGCGU--U--AAGCU-----AACC----A-GUACUAA-UUGCCC-GU--AAGG-CUUG -AUCCU-- >Rhodobacter_sphaeroides ----UCAAGC---GCGAAAAGGGCGUUU-GGUGGAUG-CCU-AGGCA-GCA-A--GAGGC GAUGAAGGACGUGAU-ACCCUGCGUUAAGCCAUGGGGAGCCGGGAA-UA-GGCUUU-GAU CCAUGGAUGUCCGAAUGGGGAAACCCACCUGAUUGUUC------------G-UUGUUGUC CUACCGCUUCGCUACUUGAGGACUCGUCCGAC---------------------------- ----AGUGGCAAGC---------G---CGGGAUCAUCAAUGGGCAAAGACAGGUAUCAUU ACCCU--------------------------GAAUACAU-A------------------- ---------------GGGGUUUUGAAGCGA-ACCCGGGGAACUGAAACAUCUAAGUACCC --GGAGGAAAGGAAAUCAA-CAGAGACUCCGUUAGU-AGU-GGCGAGCGAACGCGG-ACC AGCCGAUC-CU-CGA--------------------------------------------- ------------------------------------------------------------ ---------------------------------AGAGUGAC------UGG-AAUG--CGC UG-GA-------AAGCG------C-AGCG-AUACAGGGUGACAGCCCCGUACAGGAAGCU -C-C-A-C----------A---------GGAC-----AUAUCAAGUAGGGCGGGACACGU GAAAUCCUGUCUGAAGAUCGGGGGACCA--CCCCCGAAGGCUAAGUACUCC-UU-GCUGA CCGAUAGC-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGACGAGGGGAGU GAAACAGUACCUGAAACCGGACGCCUA-CAA-GCAGU-CGGAGGCCCA----------UG UU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CUUCCC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GCUGACGGCGUACCUUUUGUAUAAUGGGUCAA CGACUUGG-U----CUCACGAGCAA---GCUUAA-GCC--------------GGUA---- ---------GGU-G-G-A-GGCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAA--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UC------------------ ------------------------GAGUUCGUGGGAUCA-GACCCGAAACCAG-GUGAUC UAGCCAUGAGCAGGAUGAAGUCAGG-GUAACAC-CUGAUGGAGGUCCGA--ACCA-ACAC -CCGUUGAAAAGGGUCUGGAUGACUUGUGGCUAGGGGUGAAAGGCCAAUCAAACCUGG-A GAUAGCUGGUUCUCCGCGAAAGCUAUUUAGGUAGCGCCUCGGA-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-CUCGGGGGGUAGAGC-ACUGCAUGGA--UG-A UG--G-GGG-C-CCACA-GCCUUA-CUGAGUCUAAGCAAACUCCGAAUACCCG-AGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--U-CCGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAGA-GGGAA----ACA--ACCCUGACCUGC-AGCUAAG--GCCCC--CAAUUC--G U-G-GC-U-AAG--UGGGA-----------AAGCAUGUGGGACGGCCAAAACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAUAGCGUAACAGCUCACUGGUCUAGAUA AGCUGUCCUGCGGCGAAGAUGUAACGGGGCUC-A-AGCCA---CGA--------GCC--G AAG-CUCAGGA--UGC---A--C----A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------UG-U-G-C-GU-GG--UAGCG----GA ---G-CGUU-CCGUGAU-------------------AU-A-GCGCACUGUCUGUU-UG-- AU--CG--C-GACAC---C-------------------------------AAUGC--GC- -UCAAGCAGC---GAAGCGGUAGCGCGCGCAUA--UGCGCAGACAAGGCGCUUUCUGUGA AGCCG-G--G-CCGU-AA-GGCAUCCGG-U-GGA-GAGAUC-G--GAAGCGAGAAUGU-U GACAU-GAGUA-GCG-A--CAA-ACAGG-G------------------UGAGAGA----- ----------CCCUGU-CGCC-GAA-AGUCC-AAGGGUUCCU-GCUUAAAGCUAAUCUGA GCAGGG------------UGAGCCGGCCC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-AGG--U UAA----UAUU-CCU----GGGCC-A-GG-A--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GA-UGU--G-AC--GGAU-C GCAGGU--GU--A-GU-UC-G-GCC-UUAU---CGG-----AUU---GG-CCG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GC-U----GC----UGAG-CG---GUCC-CUGGAAA-U-A-GCCC---U----------- ------------------------------------------------------------ ---------CCA--UC-A-GACCGUACCCUAAACCGACACAGGUGGACU-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACCAC-AUCAAAGGAACUCGGCAAAA-UGCCUCCG UAAGUUCGCG-AGAAGGAGGCC-CC-GU-----------CUU-UG-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CCA-G-A----- G-----------------GCGG-GGGGCACAAACCAGGGGGUGGCGA-----CUGUUUAC UUAAAACACAGGGCUCUGC-GAAGCC--GC---A-A------------GGCGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAAAGGAGAGGU----------GCA A------------GCCUUGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AU-C--UCCCC--GCUGUCUCUG-AU-GUG-GACUCAGCGAAAUUGAACU-GUGUGUCAA GAUGCACACUUCCCGCGGUUAGACGGAAAGA-CCCCAUGAACC-UUUACUAUAGCUUCGC ACUGGCAUCAGGAAUGUGAUGUGCAGGAU-AGGUGGUAG-GCAU--C-GAA--ACG--GG GAC--------------------------------------------------------- ----------------------------------GCCA--GUUCC--CGUGGAGC--CA- ACCU-UGAGAUA-CCACCCUUCGCAU-UCUUGAUGUCUAA-CCGCG--GU--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UACC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-AUC-CGGGA -CCC-UGCGUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCCA-AACAGUAAC-GGAGG CGCGCGAUGGUGGGCUCAGACCGGUCGGAAAUCGGUCGUC-GAGUGC-AAUGGCAGAA-G CCCGCCUGACUG-CAAGACUG-A----CAAGUCGAGCAGAGACGAAAGUCGGCCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--AGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC UGGGGA-UAACAGGCUGAUGAUGCCCAAGAGUCCAUAUCGACGGCAUCGUUUGGCACCUC GAUGUCGGCUCAUCUCAUCCUGGGGCUGGAGCAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGAGGUACGUGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----AGGAGAC-UUGAGAAGAG--UUGCCCCUAGUACGAGAGGACCGGGGUGAACGAAC CAC-UGGUGGA-CCAGU-UGUCGUGCCAACGGC-AG--UGCUGGGUAGCUA-U-GUUCGG ACA-GGAUAACCGCUGAAGGCAUC--U-AAGCGGGAAGCC------CCC-UUCAAAA--- --CAAGGUC---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CU-U--GAGGGC---CGUG--G-AAGACCACCA-CG-UCGAUAGG CCAGA-GGUGUAAG-CGC-A-------------------------GCAA----------- --UGCGU--U--CAGCU-----GACU----G-GUACUAA-UUGCCC-GA--UUGG-CUUG -AUCUG-- >Rhodopirellula_baltica --GGCCAAUC---UA-UUAAGGGCACAU-GGGGGAUG-UCU-UGGCG-UUA-G--AAGG- --AGAAGGGCGUGGA-AGUCUGCGAAAAGCCUGGGGAAGUUGACACACA-AGCGAU-GAU CCCGGGGUUCCCGA---------------------------------------------- ------------------------------------------------------------ ---------------------------------------CC--------------ACAGC ACACU--------------------------GAAUACAU-A------------------- --------------GGUGUGUUUGU-AACA-ACCUGGUGAACUGAAACAUCUAAGUAACC --AGAGGAACAGAAAGAAA-AAUCGAUUCCGUCAGU-AGC-GGCGAGCGAAAUCGG-AAU AGCCCAAA-CCGAGGA-GG-------------------------UUUCCUUCUCGGGG-- -------------------------UUGUAGGACUU-CAA-----U--------AUGGG- --AUUG------------AG-------A-----CGUGUUAG------UGA-AACG--ACU UG-GA-------ACGGU------C-GGCC-ACAGAGGGUGACAGCCCCGUACGCGAAAAU -A-UUG-UC---------U------CACCUUA-GAAGCACCUGAGUAGGUCCAGUCACGU GAAACCUGGACUGAAUCCGCGGGGACCA--UCCCGUAAGGCUAAAUACUCU-CU-AACGA CCGAUAGC-GAACC-AGUAGCGUGAGUGAAUGGUGAGA-AGAAC-CCCUGCUAGGGGAGG -AAUGUGAACCUGAAACCAUGUGCCUA-CAA-GCGGU-CGGAGCACUA----------UU UU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AAUG--------UGUGACGGCGUGCCUUUUGCAUAAUGAUCCGG CGAGUUGU-G----GUAAUCGGC-UU--GGUUAA-GUU--C-U---------G-AC---- -------GGAAC-G-A-A-GCCCAAGGGAAA-CCA------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------U------------------- ------------------------UGGUCGAUUGCUGCA-GACGCGAAACCUGUGUGAUC UACCCAUGGGCAGGUUGAAGCGCGG-GUUAAAC-UGCGUGGAGGACCGA--ACCC-ACUU -AGGUUGAAAACUGAGGGGAUGACCUGUGGGGAGGACUGAAAGUGUAAUCAAACCAGG-A GAUAGCUCGUUCUCUCCGAAAUAUCUUGAGGGAUAGCGUCGAG-U--------------- ------------------------------------------------------------ -------------------AAAUUAGU-GACCGGGGGUAGAGAUACUGAAUCGG-AUG-G GG--G-CCC-U-UCCA--AGGGUA-CCCCACCGAACCAAACUCCGAAUACCGG-UUC-A- C-C--------------------------------------------------------- ------------------------------------------------------------ ---------UU--AC--C-UCGGC-AGU-CAG-UCC--CU-GGGGGAUAAGCUCCAG-GG -UCGAGA-GGGAA----ACA--ACCCAGAUCGCC-UGCUAAG--GUCCC--GAAG-U--A C-U-AC-U-UAG--UCACU-----------AAGGAAGUUGAAGUGCCGUGACAGCUGGGA UGUUGGCUUAG-AAGCAGCCAC-CAUUUAAAAAGUGCGUAACAGCUUACCAGUC-----G AGCAUUUCUGCGCCGAUAAUG-AACGGGAGU--A-AGUAG---UAC--------ACC--G AAG-CAGCGGA--UUC---U--A----GA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUA----------------------------- --------------------------------UCU-A-G-A-GU-GG--UAGGA----GA ---G-CGCC-GAU-GAU-------------------CA-GA------------------- ------------------------------------------------------------ --------------------------------------------------------UACG AGCCG-U--A-CGGU-AA-CGA--GCGG-U-GUCGGGGUCA-U--CGGGUGAUUAUGC-C GGAAU-GAGUA-ACG-A--UAA-AACAG-G------------------UGAGAAU----- ----------CCUGUU-CGCC-GAA-AGCCU-AAGGUUUCCU-GGGGAAGGUAAAUCCGC CCAGGG------------UUAGCCGGUAC-C-UUA----GUCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------AC---GA--U-GGAU-AGA-AGG--U CAA----UAUU-CCU----UCGCC-A-CA-U--GGGU-A-C------------------- ----------------------------------------------------------UU CGA--------------------------------------------------------- ----------------------------------------UG-CGG-GG-AC--GGCG-U CCAGAA--AG--U-GAGCG-GUACG--AA----UAGA-----AA---UG-UCC-G-UA-- -G-------CG------AA-A------A----------C----U---------G----AG G-U------G---UU-GGGG--G----AU--AAAUGACCU-GACAU-AA----G-CC--A -AG-G--U--U-G--A--G------CU-C--GA--GA-GC-------------------- ---------AUCCAA--------------------------------G-UUC--UCGAAG UC-A----UU-GG-AA-G-GA---CGUC-CAAGAAA-A-G-CCGC---U--A-AGU-UA- U----------------------------------------------------------- ----GU-G-CCC--UG-U-GACCGUACU-AAAACUGACACAGGUAGGCG-AGA-UGAGAA -U-UCUAAGG-CG-CU-CGGG-AGAACGGU-GGUUAAGGAACUCUGCAAAA-UGGCCCCG UAAGUUCGCG-AUAAGGGGCGC-CU-CC--G-AC-GGU---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U CA-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GC-U-G--U-UGGAG-GCCACAGAAAAUCGGCUCUAACGA-----CUGUUUAU CAAAAACACAGGUCUCUGC-UAACAC--GC---A-A------------GUGGAU-GU-AU AGAGACUG-ACGCCUGCCCGGUGU-U-GGUAGGUUAAGGAAGACGGUUAGCUC----UUC G-----GAGCGAAGCUGGCGACCGAAGCCCCA-A-UAAACGG-CGGCCCUAACUAUGAGG GUCCUAAGGUAGCGAAGUUCCUUGUCGGG-UAAGUUCCGACCUGCAUGAAAGGCGUAACG AU-U--GGAGC--ACUGUCUCAA-CC-ACC-GACCCGGUGAAAUUGUAGU-UGUGGUGAA GAUGCCACAUACCCGCGGUUAGACGGAAAGA-CCCCGUGAACC-UUUACUGUAGGCUGCU AUUGGGUUGAGAUAUGUCUUGUGUAGGAU-AGCUGGGAG-AC-UU-U-GAA--CUU--UG CAC--------------------------------------------------------- ----------------------------------GCUA--GUGUA--GAGGGAGU--CG- UUGU-UGAAAUA-CCAGCCUGGUCAU-AUUUUAAUUCUAA-CUU-U--GAUC------CC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GG-G-GCA-AAGGA -CAG-UGUCAGUCGGGCAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGUGCAAAGGUACACUCAGCCUGGUCGGCAAUCAGGCGUA-GAGCGU-AAAGGUAGAA-G UGUGCUUGACUG-CGAGACUC-A----UAAGUCGAGCAGGAACGAAAGUUGGCCUU-AGU G-AUCCGGUA-------------------------A---------UCCCG--AAU-GGA- -----------------------------AGGGUUAUCGCUCAUCAGAUAAAAGGUACUC CGGGGA-UAACAGGCUUAUCGCAUCCGAGCGUCCACAGCGGCGAUGCGGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGGUGUAGAAGCUCCCAAGGGUUUGGCUGUUCGCCAA UGAAAGUGGUACGUGAGCUGGGUUCAGACCGUCGUGAGACAGGUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UCGAAUC-UUGAUGGGAU--UCAACUUUAGUACGAGAGGAUUUAGUUGGACGAAG CUC-UGGUGUA-CCAGU-UGUCGCGCUAGCGGC-AC--GGCUGGAUAGCUA-A-CUUCGG AAA-GGAUAAACGCUGAAAGCAUC--U-AAGCGUGAAGCC------CGC-CCAGAGA--- --UAAGGAU---------------------------UC--GUA--------GA-C----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUUA----------------------------- -----------GUC--GAA---AGCCC---CCUG--G-AAGACUACCA-GG-UUGAUAGG UUGGA-CGUGUAAG-UGC-A-------------------------GUAA----------- --UGCAU--U--AAGCA-----AACC----A-AUACUAA-C-GGGC-GA---AAG-UUUG -GCCA--- >Shewanella_oneidensis --GGUUAAGC---GA-CUAAGCGUAUAC-GGUGGAUG-CCU-UGGCA-GUC-A--GAGGC GAUGAAGGACGUAGU-AACUUGCGAAAAGCGUUGGCGAGCUAGUAACAA-GCAUUU-GAG CUAACGAUGUCCGAAUGGGGGAACCCGGCCGCAUA------------------AG----- ---------------C-------------------------------------------- ------------------------------------G-GUCA-------------UCA-U AACGU--------------------------GAAUACAU-A------------------- ---------------GCGUU-AUGAGGCAA-ACGAGGGGAACUGAAACAUCUAAGUACCC --UUAGGAAAAGAAAUCAA-CCGAGAUUCCCCUAGU-AGC-GGCGAGCGAACGGGG-AUU AGCCCU-U-AA-------G-------------------------UCAGA----------- ------------------------------------------------------------ -------------------G-------G-----GGUGUUAG------UGG-AAUG--GUC UG-GA-------AAGUC------C-AGCG-GCACAGGGUGAUAGCCCCGUACACGAAAAC ---UAA-CC---------U-------UUGAUG-AAAAC----GAGUAAGGCGGGACACGU GAUAUCCUGUUUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCUGUGAGGGGAGU GAAAUAGAACCUGAAACCGUAUACGUA-CAA-GCAGU-GGGAGCGGU------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ACUUG-AGAC---------CGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-G----UUUUGUAGCGA---GGUUAA-GCG--------------AAU----- ---------AGC-G-G-A-GCCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU GUU---------------------------------------AAC--------------- -------------------------------------------U-GCGCG---------- ----------------------------------------UU------------------ ------------------------UAGUUGCAAGGCGUA-GACCCGAAACCCG-GUGAUC UAGCCAUGGGCAGGUUGAAGGUUGA-GUAACAU-CAACUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGG-A GAUAUCUGGUUCUCCUCGAAAGCUAUUUAGGUAGCGCCUCGAG-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-CAUUGGGGGUAGAGC-ACUGUUAAGG--CU-A GG--G-GGU-C-AUCCC-GACUUA-CCAACCCUUUGCAAACUCCGAAUACCAA-UGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ -------------CUA-C-UCGGG-AGA-CAG-ACG--GC-GGGUGCUAACGUCCGU-CG -UCAAAA-GGGAA----ACA--ACCCAGACCGUC-AGCUAAG--GUCCC--AAAGUG--U A-U-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCUUAGACAGCUAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCU--A-AACAU---ACC--------ACC--G AAG-CUACGGG--UGC---A--A----UC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUUA----------------------------- -------------------------------GGGU-U-G-C-GC-GG--UAGAG----GA ---G-CGUU-CUGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGGUG-AA-G-GGGU-AA-CCC--ACAC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-ACG-A--UAA-AGGGG-G------------------UGAAAAA----- ----------CCCCCU-CGCC-GAA-AGACC-AAGGGUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UGAGUCGACCC-C-UAA----GGUG-A-GGCCGAA--AGGCG ---------------------------U-A-A---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGA--U UAA----UAUU-UCU----GUACU-U-UU-G--CUAA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GAG-AG-AC--GGAG-A AGGCUA--GG--C-UA-GC-G-CGG--CGU---UGG-----UAGU--CC-GCG-U-UU-- -A------AGG------UG-G------U------A---G----G---U-----G----GG U-G------A---CU-UA-G--G-----C--AAA-U-CCG-GGUCA-CU-----AUAC-A -CU-G--A-GA-G--C--U-G--A-UG-A-CGA--GU-CCC------------------- ---------CA-AG--------------------------------GG-GAU--GAA--G UA-G----UU-GAUGC-CAUG---CUUC-CAGGAAA-A-U-CUUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--GU-U-AGU--AG-G-AAUCGUACCCCAAACCGACACAGGUGGUCG-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACUCG-GCUGAAGGAACUAGGCAAAA-UGGUACCG UAACUUCGGG-AGAAGGUACGC-UC-CU--G-UU-GGUGAUG-AG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UCU-C-U----- A-----AGC-U-G--A-CGGGA-GUCGCAGAUACCAGGUGGCUGCAA-----CUGUUUAU CAAAAACACAGCACUGUGC-AAACUC--GC---A-A------------GAGGAA-GU-AU ACGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAUUGGGUU-AUC-----GCA A------GAG-AAGCUCAUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAC--GCUGUCUCCA-GC-CGA-GACUCAGUGAAGUUGAAAU-UGCGGUGAA GAUGCCGUAUACCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGGC ACUGAACAUUGACCCUACAUGUGUAGGAU-AGGUGGGAG-AC-UU-U-GAA--GUU--GG AAC--------------------------------------------------------- ----------------------------------GCUA--GUUCU--GAUGGAGU--CG- UCCU-UGAAAUA-CCACCCUUGUAGU-GUUGAUGUUCUAA-CUUGG--CC--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-GGU-AAGGA -CAG-UGCCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGCACGAAGGUUGGCUAAGUACGGUCGGACAUCGUACGGU-UAGUGC-AAUGGCAUAA-G CCAGCUUAACUG-CGAGACAG-A----CACGUCGAGCAGGUACGAAAGUAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGUCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAUGA-UUGAGGGGAG--UUGCUCCUAGUACGAGAGGACCGGAGUGAACGAAC CGC-UGGUGUU-CGGGU-UGUCAUGCCAAUGGC-AU--UGCCCGGUAGCUA-U-GUUCGG AAU-CGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCG------AGC-CCCAAGA--- --UGAGUCA---------------------------UC--CCU--------UG-G--A-- C--U-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- -------AG-UCCA-CUAA---AGAGC---CGUU--C-GAGACUAGGA-CG-UUGAUAGG UCAGG-UGUGUAAG-CGU-U-------------------------GUGA----------- --GGCGU--U--GAGCU-----AACU----G-AUACUAA-UGACUC-GA--GAGG-CUUA -ACCAU-- >Sinorhizobium_meliloti --GAUCAAGU---GAAAGAAGGGCAUUU-GGUGGAUG-CCU-UGGCA-UGC-A--CAGGC GAUGAAGGACGUGAU-ACGCUGCGAAAAGCCGUGGGGAGCUGCGAA-UG-AGCUUU-GAU CCAUGGAUCUCCGAAUGGGGCAACCCACCUUAGAUGCUUGGAAAA-UCA----UUUUG-- -GUUGGCAUCUGG--UCCCGAAGCCGUAAGGCUUCGCAAGGCCAGAGGCCGUCGCCGGUU AUCCGGCGUCAAGAAACCAAAGUG-------GUUUCCAAGCAUUGUUGAAAGGUAUCUUA UU-CU--------------------------GAAUACAU-A------------------- ---------------GGG-AUAAGAAGCGA-ACGCAGGGAACUGAAACAUCUAAGUACCU --GCAGGAAAGGACAUCAA-CCGAGACUCCGCAAGU-AGU-GGCGAGCGAACGCGG-ACC AGGCCAGU-GG-CAA------------------------------UG-A----------- ------------------------------------------------------------ -------------------G-------------GAAUAAAG------UGG-AACG--AUC UG-GA-------AAGUU------C-GGCC-GUAGCGGGUGAUAGCCCCGUACACGUAGAA -C-A-C-UC---------A---------U-UG-----UCCUUGAGUAAGGCGGGACACGU GAAAUCCUGUCUGAACAUGGGGAGACCA--CUCUCCAAGCCUAAGUACUCG-UG-CAUGA CCGAUAGC-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCGACAAGGGGAGU GAAAUAGAACCUGAAACCGGAUGCCUA-CAA-ACAGU-CGGAGC---------------- --------------------------------------------------C--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCAAG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUACCUUUUGUAUAAUGGGUCAA CGACUUAG-U----GUGGCAUGCAA---GCUUAA-GCC--------------GGUA---- ---------GGU-G-G-A-GGCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAC--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------CUU------------------ ------------------------UAGUAUGUCGCAUUA-GACCCGAAACCGA-GUGAUC UAGCCAUGAGCAGGUUGAAGGUUGG-GUAACAC-CAACUGGAGGACCGA--ACCC-GCAU -CUGUUGCAAUAGAUUGGGAUGACUUGUGGCUAGGGGUGAAAGGCCAAUCAAACUCGG-A AAUAGCUGGUUCUCCGCGAAAACUAUUUAGGUAGUGCGUCGAC-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-CCUCGGGGGUAGAGC-ACUGGAUGGG--CU-A UG--G-GGA-C-UCACC-GUCUUA-CUGAUCCUAACCAAACUCCGAAUACCGA-GGA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ ----------C--UA--G-UCGGC-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAAA-GGGCA----ACA--ACCCUGACCUCC-AGCUAAG--GUCCC--CAAGUC--A U-G-GC-U-AAG--UGGGA-----------AAGGAUGUGAGGAUCCCAAAACAACCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAACAGCUCACUGGUCUAAAUA AGGGUCUUUGCGCCGAAAAUGUAACGGGGCUG-A-AGCCA---UGC--------ACC--G AAG-CUGAGGA--UAC---G--U----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ---------------------------------GA-C-G-U-GU-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------CC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGGA-U-AC-CCGU-GA-GGG--GUCC-U-GGA-GGUAUC-G--GAAGUGCGAAUGU-U GACAU-GAGUA-ACG-A--UAA-AGAGG-G------------------UGAGAGA----- ----------CCCUCU-CGCC-GAA-AGACC-AAGGGUUCCU-GCUUAAAGUUAAUCUGA GCAGGG------------UUAGCCGGCCC-C-UAA----GACG-A-GGCGGAC--ACGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-ACC-ACG--U UAA----UAUU-CGU----GGGCC-U-GG-U--G-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GU-AGU--G-AC--GGAU-U GCUCAA--CU--U-GU-CC-G-GAC-UUAU---UGG-----AUU---GU-CCG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GC-G----GG----GACG-CG---GUUC-CAGGAAA-U-A-GCUC---C--A-------- ------------------------------------------------------------ ---------CCG--UAUA-GACCGUACCCGAAACCGACACAGGUGGUCA-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAACUAU-GUUGAAGGAACUCGGCAAAU-UGCACGCG UAACUUCGGA-AGAAGCGUGAC-CC-UU-----------UUC-UA-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GUA-G-G----- A-----------------UGGG-GUGGCACAGACCAGGGGGUAGCGA-----CUGUUUAU CAAAAACACAGGGCUCUGC-GAAGUC--GC---A-A------------GACGAC-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGGGGU----------GCA A------------GCUCUGAAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--GCUGUCUCCA-AC-AUA-GACUCAGUGAAAUUGAAUU-CCCCGUGAA GAUGCGGGGUUCCUGCGGUCAGACGGAAAGA-CCCCGUGCACC-UUUACUAUAGCUUUAC ACUGGCAUUCGUGUCGGCAUGUGUAGGAU-AGGUGGUAG-GC-UU-U-GAA--GCG--GG GAC--------------------------------------------------------- ----------------------------------GCCA--GUUCU--CGUGGAGC--CA- UCCUU-GAAAUA-CCACCCUUAUCGU-CAUGGAUGUCUAA-CCGCG--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-CAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUC-CGGGA -CAG-UGUAUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCGA-AAGAGUAAC-GGAGG CGCGCGAUGGUGGGCUCAGAGCGGUCGGAAAUCGCUCGUC-GAGUGC-AAUGGCAUAA-G CCCGCCUGACUG-CGAGACUG-A----CAAGUCGAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCG--CGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUGACCCCCAAGAGUCCAUAUCGACGGGGUUGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-UGU------------------------------------------------ -----AGGAAUA-UUGACAGGAU--CUGUCCCUAGUACGAGAGGACCGGGAUGGACAUAU CUC-UGGUGGA-CCUGU-UGUCCUGCCAAGGGC-AU--AGCAGGGUAGCUA-U-AUAUGG AAG-GGAUAACCGCUGAAGGCAUC--U-AAGCGGGAAACC------CAC-CUGAAAA--- --CGAGUAU---------------------------UC--C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CU-U--GAGAAC---CGUG--G-AAGACGACCA-CG-UUGAUAGG CCGGG-UGUGGAAG-UGC-G-------------------------GCAA----------- --CGCAU--G--AAGCU-----UACC----G-GUACUAA-UCGUUC-GA--UUGG-CUUG -AUCGU-- >Staphylococcus_aureus --GAUUAAGU---U-AUUAAGGGCGCAC-GGUGGAUG-CCU-UGGCA-CUA-G--AAGCC GAUGAAGGACGUUAC-UAACGACGAUAUGCUUUGGGGAGCUGUAAG-UA-AGCUU-UGAU CCAGAGAUUUCCGAAUGGGGAAACCCAGCAUG-AGUU----------------------- ---------------AU------------------------------------------- ---------------------------------GUCAUGUUA-------------UCG-A UAUGU--------------------------GAAUACAU-A------------------- -------------GCAUAUCAGAAGGCACA--CCCGGAGAACUGAAACAUCUUAGUACCC --GGAGGAAGAGAAAGAAA-AUUCGAUUCCCUUAGU-AGCCGGCGAGCGAAACGGGA-AG AGCCCAAA-CCAACAA--GC-----------UU-----------G---CUUGUUGGGG-- -------------------------UUGUAGGACACUCUA-------------------- ----UACGGAGUUACAAAGG--------A---CGACAUUAG------ACG-AAUC--AUC UG-GA-------AAGAU------G-AAUC-AAAGAAGGUAAUAAUCCUGUAGUCGAAAAU -G-UUG-UC---------UCU----CUUGAG---UGGAUCCUGAGUACGACGGAGCACGU GAAAUUCCGUCGGAAUCUGGGAGGACCA--UCUCCUAAGGCUAAAUACUCU-CU-AGUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GAAGGGGAGU GAAAUAGAACCUGAAACCGUGUGCUUA-CAA-GUAGU-CAGAGCCCGU----------UA AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAUGGCGUGCCUUUUGUAGAAUGAACCGG CGAGUUAC-G----AUUUGAUGCAA---GGUUAA-GCA-------------GUAAA---- ---------UGU-G-G-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------UU------------------ ------------------------UAGUAUUUGGUCGUA-GACCCGAAACCAG-GUGAUC UACCCUUGGUCAGGUUGAAGUUCAG-GUAACAC-UGAAUGGAGGACCGA--ACCG-ACUU -ACGUUGAAAAGUGAGCGGAUGAACUGAGGGUAGCGGAGAAAUUCCAAUCGAACCUGG-A GAUAGCUGGUUCUCUCCGAAAUAGCUUUAGGGCUAGCCUCAAG-U--------------- ------------------------------------------------------------ --------------------GAUG-AU-UAUUGGAGGUAGAGC-ACUGUUUGGA--CG-A GG--G-GCC-C-CUCUC-GGGUUA-CCGAAUUCAGACAAACUCCGAAUGCCAAUUA--A- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------U--AA--C-UUGGG-AGU-CAG-AAC--AU-GGGUGAUAAGGUCCGU-GU -UCGAAA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--AAAAUA--U A-U-GU-U-AAG--UGGAA-----------AAGGAUGUGGCGUUGCCCAGACAACUAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAGUGCGUAAUAGCUCACUAGUC-----G AGUGACACUGCGCCGAAAAUGUACCGGGGCU--A-AACAU---AUU--------ACC--G AAG-CUGUGGA--UUG---U--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUU------------------------------ ---------------------------------GG-A-C-A-AU-GG--UAGGA----GA ---G-CGUU-CUAAG-G-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCAU-G--A-UCGU-AA-GGA--CAUG-U-GGA-GCGCUU-A--GAAGUGAGAAUGC-C GGUGU-GAGUA-GCG-A---AA-GACGG-G------------------UGAGAAU----- ----------CCCGUC-CACC-GAU-UGACU-AAGGUUUCCA-GAGGAAGGCUCGUCCGC UCUGGG------------UUAGUCGGGUC-C-UAA----GCUG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGAU-AAC-AGG--U UGA----UAUU-CCU----GUACC-A-CC-U--AUAA-U-C------------------- ----------------------------------------------------GUUUUAAU CGA--------------------------------------------------------- ----------------------------------------UGGGGG-GG-AC--GCAG-U AGGAUA--GG--C-GAAGC-G-UGC--GAU---UGG-----AUU---GC-ACG-U-CU-- -A------AGC------AG-U------A------A---G----G---C-----U----GA G--------U---AU-UA-G--G-----C--AAA-U-CCG-GUA-C-UC----AUUAAGG -CU-G--A-GC-U--G--U-G--A-UG-G-GGA--GA-AGACA----------------- ----------U-UG----------------------------UG--UC-UUC--GA---G UC-G----UU-GAUUU-CACA---CUGC-CGAGAAA-A-G-CCUC---U--A-GAU---- -A---------------------------------------------------------- -G--AA-A-AUA--GG-U-GCCCGUACCGCAAACCGACACAGGUAGUCA-AGA-UGAGAA -U-UCUAAGG-UG-AG-CGAG-CGAACUCU-CGUUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-UC-UU--U-AG-GGU---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U AA-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GC-C-C--A-GAAGA-GCCGCAGUGAAUAGGCCCAAGCGA-----CUGUUUAU CAAAAACACAGGUCUCUGC-UAAACC--GU---A-A------------GGUGAU-GU-AU AGGGGCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGUGGUU-AGC-----UUC U------GCG-AAGCUACGAAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAACG AU-U--UGGGC--ACUGUCUCAA-CG-AGA-GACUCGGUGAAAUCAUAGU-ACCUGUGAA GAUGCAGGUUACCCGCGACAGGACGGAAAGA-CCCCGUGGAGC-UUUACUGUAGCCUGAU AUUGAAAUUCGGCACAGCUUGUACAGGAU-AGGUAGGAG-CC-U--UUGAA--ACG--UG AGC--------------------------------------------------------- ----------------------------------GCUA--GCUUA--CGUGGAGG--CG- CUGG-UGGGAUA-CUACCCUAGCUGU-GUUGGCUUUCUAA-CCCGC--AC--------CA C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GU-G-GUG-GGAGA -CAG-UGUCAGGCGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCUCAAAGGUUCCCUCAGAAUGGUUGGAAAUCAUUCAUA-GAGUGU-AAAGGCAUAA-G GGAGCUUGACUG-CGAGACCU-A----CAAGUCGAGCAGGGUCGAAAGACGGACUU-AGU G-AUCCGGUG-------------------------G---------UUCCG--CAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGCUACCC CGGGGA-UAACAGGCUUAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --UGG--G-CGU------------------------------------------------ -----AGGAAAU-UUGAGAGGAG--CUGUCCUUAGUACGAGAGGACCGGGAUGGACAUAC CUC-UGGUGUA-CCAGU-UGUCGUGCCAACGGC-AU--AGCUGGGUAGCUA-U-GUGUGG ACG-GGAUAAGUGCUGAAAGCAUU--U-AAGCAUGAAGCC------CCC-CUCAAGA--- --UGAGAUU---------------------------UC--CC----------A-A--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUCG----------------------------- ----------GUU----AU--AAGAUC---CCUC--A-UAGAUGAUGA-GG-UUAAUAGG UUCGA-GGUGGAAG-CAU-G-------------------------GUGA----------- --CAUGU--G--GAGCU-----GACG----A-AUACUAA-UCGAUC-GA---AGA-CUUA -AUCAA-- >Streptococcus_pneumoniae --GGUUAAGU---U-AAUAAGGGCGCAC-GGUGGAUG-CCU-UGGCA-CUA-G--GAGCC GACGAAGGACGUGAC-AAACGACGAUAUGCCUUGGGUAGCUGUAAG-UA-AGCGA-UGAU CCAGGGAUUUCCGAAUGGGGGAACCCAACAGG---UA----------------------- ---------------AU------------------------------------------- ----------------------------------ACCUGUUA-------------CCC-A CAUCU--------------------------G-UUAA----------------------- -------------GGAUGUGAGGAGGAAGA--CGCAGUGAACUGAAACAUCUAAGUAGCU --GCAGGAAGAGAAAGCAA-AAGCGAUUGCCUUAGU-AGC-GGCGAGCGAAACGGCA-GG AGGGCAAA-CCGAAGA--GU-----------UU-----------A---CUCUUCGGGG-- -------------------------UUGUAGGACUGCAA--------------------- ----UGUGGACUCA--------------A---AGAUUAUAG------AAG-AAUG--AUU UG-GG-------AAGAU------C-AGCC-AAAGAGAGUAAUAGCCUCGUAUUUAAAAUA -G-UCU-UU---------GUA----CUUAGC---AGUAUCCUGAGUACGGCGGGACACGU GAAAUCCCGUCGGAAUCUGGGAGGACCA--UCUCCCAACCCUAAAUACUCC-CU-AGUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GGAGGGGAGU GAAAUAGAACCUGAAACCGUGUGCCUA-CAA-CAAGU-UCGAGCCCGU----------UA AU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------G------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGAGAGCGUGCCUUUUGUAGAAUGAACCGG CGAGUUAC-G----UUAUGAUGCGA---GGUUAA-GUU-------------GAAGA---- ---------GAC-G-G-A-GCCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCA---------- ---------------------------------------CCU------------------ ------------------------UAGUAUCAUGACGUA-GACCCGAAACCAU-GUGACC UACCCAUGAGCAGGUUGAAGGUGCG-GUAAGAC-GCACUGGAGGACCGA--ACCA-GGGC -ACGUUGAAAAGUGCUUGGAUGACUUGUGGGUAGCGGAGAAAUUCCAAACGAACUUGG-A GAUAGCUGGUUCUCUCCGAAAUAGCUUUAGGGCUAGCGUCGAC-A--------------- ------------------------------------------------------------ ------------------UUAGAG-AU-UCUUGGAGGUAGAGC-ACUGUUUGGG--UG-A GG--G-GUC-C-AUCCC-GGAUUA-CCAAUCUCAGAUAAACUCCGAAUGCCAAUGA--A- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UG--G-UCGGC-AGU-CAG-ACU--GC-GAGUGCUAAGAUCCGU-AG -UCGAAA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--AAAAUA--A U-U-GU-U-AAG--UGGAA-----------AAGGAUGUGGGGUUGCACAGACAACUAGGA UGUUAGCUUAG-AAGCAGCUAUUCAUUCAAAGAGUGCGUAAUAGCUCACUAGUC-----G AGUGACCCUGCGCCGAAAAUGUACCGGGGCUA-A-AACAA---UUU--------ACC--G AAG-CUGUGGA--U-A---C--C----U-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAU----------------------------- ---------------------------------AG-G-U---AU-GG--UAGGA----GA ---G-CGUU-CUAUG-U-------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGUA-U--A-CCGU-GA-GGA--GUGC-U-GGA-ACGCAU-A--GAAGUGAGAAUGC-C GGUAU-GAGUA-GCG-A---AA-GACAG-G------------------UGAGAAU----- ----------CCUGUC-CACC-GUA-AGACU-AAGGUUUCCA-GGGGAAGGCUCGUCCGC CCUGGG------------UUAGUCGGGAC-C-UAA----GGAG-A-GACCGAA--AGGUG ---------------------------U-A-U---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--U-GGAC-AAC-AGG--U UGA----UAUU-CCU----GUACU-A-GA-G--UAUG-U-A------------------- -----------------------------------------------------------G UGA--------------------------------------------------------- ----------------------------------------UG-GAG-GG-AC--GCAG-U AGGCUA--AC--U-AAAGC-A-GAC--GAU---UGGA----AGA---GU-CUG-U-CU-- -A------AGC------AG-U------G------A---G----G---U-----G----U- G-A------A---UU-GA-G--U-----C--AAA-U-GCUUAAUUC-UA----U-AAC-A -UU-G--A-GC-U--G--U-G--A-UG-G-GGA--GC-GAA------------------- ---------GU-UUA-------------------------------GU-AGC--GAA--G UU-A----GU-GACGU-CACA---CUGC-CAAGAAA-A-G-CUUC---U--A-GCG-UU- UA---------------------------------------------------------- -A--CC-A-UAC--UC-U-ACCCGUACCGCAAACCGACACAGGUAGUCG-AGG-CGAGUA -G-CCUCAGG-UG-AG-CGAG-AGAACUCU-CGUUAAGGAACUCGGCAAAA-UGACCCCG UAACUUCGGG-AGAAGGGGUGC-UG-AC--U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------AGUCA-GCCGCAGUGAAUAGGCCCAAGCAA-----CUGUUUAU CAAAAACACAGCUCUCUGC-UAAAUC--GU---A-A------------GAUGAU-GU-AU AGGGGGUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGUGCUU-AGC-----GUA A------GCG-AAGGUAUGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAAUG AU-U--UGGGC--ACUGUCUCAA-CG-AGA-GACUCGGUGAAAUUUUAGU-ACCUGUGAA GAUGCAGGUUACCCGCGACAGGACGGAAAGA-CCCCAUGGAGC-UUUACUGCAGUUUGAU AUUGAGUGUCUGUACCACAUGUACAGGAU-AGGUAGGAG-UC-UA-A-GAG--AUC--GG GAC--------------------------------------------------------- ----------------------------------GCCA--GUUUC--GAAGGAGA--CG- CUGU-UGGGAUA-CUACCCUUGUGUU-AUGGCCACUCUAA-CCCAG--AU--------AG G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CC-U-AUC-GGAGA -CAG-UGUCUGACGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGAAUGGUUGGAAAUCAUUCGCA-GAGUGU-AAAGGUAUAA-G GGAGCUUGACUG-CGAGAGCU-A----CAACUCGAGCAGGGACGAAAGUCGGGCUU-AGU G-AUCCGGUG-------------------------G---------UUCCG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGCUACCC UGGGGA-UAACAGGCUUAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --CGG--G-CGU------------------------------------------------ -----AGGAAAU-UUGAGAGGAU--CUGCUCCUAGUACGAGAGGACCAGAGUGGACUUAC CGC-UGGUGUA-CCAGU-UGUCUUGCCAAAGGC-AU--CGCUGGGUAGCUA-U-GUAGGG AAG-GGAUAAACGCUGAAAGCAUC--U-AAGUGUGAAACC------CAC-CUCAAGA--- --UGAGAUU---------------------------UC--CCA--------UG-A--U-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UAUAU---------------------------- ----------AUCA---GU--AAGAGC---CCUG--A-GAGAUGAUCA-GG-UAGAUAGG UUAGA-AGUGGAAG-UGU-G-------------------------GCGA----------- --CACAU--G--UAGCG-----GACU----A-AUACUAA-UAGCUC-GA---GGA-CUUA -UCCAA-- >Streptomyces_coelicolor --GGCCAAGU---U-UUUAAGGGCGCAC-GGUGGAUG-CCU-UGGCA-CCA-G--GAACC GAUGAAGGACGUGGG-AGGCCACGAUAGGCCCCGGGGAGUCGUCAACCA-GGCUUU-GAU CCGGGGGUGUCCGAAUGGGGAAACCCGGCA-----GU----------------CGUC--- ---------------AU------------------------------------------- ---------------------------------GGGCUGUCA-------------CCC-G CUGCU--------------------------GAACACAU-A------------------- ---------------GGCAGUGUGGAGGGA-ACGCGGGGAAGUGAAACAUCUCAGUACCC --GCAGGAAGAGAAAACAA-CCGUGAUUCCGGGAGU-AGU-GGCGAGCGAAACCGG-AUG AGGCCAAA-CCGUAUACGUGUGA-GACCCG-GCAGGGG------UUGCGUGUGCGGGG-- -------------------------UUGUGGGAUCUCUCUUUUA-CGGUCUGCCGGCCG- --UGAGACGAGUCAGA--AACC-----GU---UGAUGUAGG------CG--AAGG--ACA UGCGA-------AAGGU------C-CGGC-GUAGAGGGUAAGACCCCCGUAGUCGAAACG -U-CAA-CG---------GCU----CG-UUUGAGAGACACCCAAGUAGCACGGGGCCCGA GAAAUCCCGUGUGAAUCUGGCGGGACCA--CCCGCUAAGCCUAAAUAUUCC-CU-GGUGA CCGAUAGC-GGAU--AGUACCGUGAGGGAAUGGUGAAA-AGUAC-CGCGG-GAGCGGAGU GAAAUAGUACCUGAAACCGUGUGCCUA-CAA-GCCGU-GGGAGCGUCG----------GG AUGGAGC-----------------------------------------------UU---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCUCCAUCCU--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CGUGACUGCGUGCCUUUUGAAGAAUGAGCCUG CGAGUUUGCG----GUGUGUUGCGA---GGUUAA-CCC--------------GAGU---- ---------GGG-G-A-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------UUUU----------------- ------------------------UAGUAGCACGCUCAA-GACCCGAAGCGGA-GUGAUC UAGCCAUGGGCAGGUUGAAGCGGCU-GUAAGAG-GUCGUGGAGGACCGA--ACCC-ACCA -GGGUUGAAAACCUGGGGGAUGACCUGUGGUUAGGGGUGAAAGGCCAAUCAAACUCCG-U GAUAGCUGGUUCUCCCCGAAAUGCAUUUAGGUGCAGCGUCGUG-U--------------- ------------------------------------------------------------ --------------------GUUU-CU-UGCCGGAGGUAGAGC-ACUGGAUAGG--CG-A UG--G-GCC-C-UACC--GGGUUA-CUGACCUUAGCCAAACUCCGAAUGCCGG-UA--A- GUG--------------------------------------------------------- ------------------------------------------------------------ ---------AG--AG--C-GCGGC-AGU-GAG-ACU--GU-GGGGGAUAAGCUCCAU-GG -UCGAGA-GGGAA----ACA--GCCCAGAGCAUC-GACUAAG--GCCCC--UAAGCG--U A-C-GC-U-AAG--UGGGA-----------AAGGAUGUGGAGUCGCACAGACAACCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----U AGUGAUUCCGCGCCGACAAUGUAGCGGGGCUC-A-AGCGU---ACC--------GCC--G AAG-UCGUGUC--AUU---G--C----AG-C----------AAU-ACG-G---------- ----C------------------------------------------------------- ------------------------------------------------------------ ---------------------------CAAC----------------------------- ---------G-----CC----G---------GCUG-U-G-A-UG-GG--UAGGG----GA ---G-CGUC-GUGU-GC-------------------CG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGCAG-C--C-GCGG-AA-GCGA-GUUG-U-GGA-CGGUUC-A--CGAGUGAGAAUGC-A GGCAU-GAGUA-GCG-A---UA-CAAAC-G------------------UGAGAAA----- ----------CGUUUG-CGCC-GAU-UGACU-AAGGGUUCCU-GGGUCAAGCUGAUCUGC CCAGGG------------UAAGUCGGGAC-C-UAA----GGCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAU-AAC-CGG--U UGA----UAUU-CCG----GUACC-C-GC-U--GUGA-A-G----C----G--UCAAACA UCGAGCAUCGUGAUGCUAAGGCCGU-GA---AGCCGCC-CUGA---UCUC---------U UCG-----GAGU-UGAGGGGAGUGGUG---GA-GCCGCCGA-ACCAAGCGGUUAGUAGGU G-----AGU-G----------------------------AUG-GGG-UG-AC--GCAG-G AAGGUA--GU--C-CA-UCCC-GGG--CGG---UGGU----UGU---CC-CGG-G-GU-- -A------AGG------GU-G------U------A---G----G---C----------CG G-U------G---UG-UA-G--G-----U--AAA-U-CCG-CACAC-CU----U-GUG-G -CU-G--A-GA-C--C--U-G--A-UG-C-CGA--GC-CG-------------------- ---------AU-UG---------------------------------U-GGU--GAA--G UG-G----AU-GAUCC-UAUG---CUGU-CGAGAAA-A-G-CCUC---U--A-GCG--A- G----------------------------------------------------------- -U--UU-C-AUG--GC-G-GCCCGUACCCUAAACCGACUCAGGUGGUCA-GGU-AGAGAA -U-ACCGAGG-CG-UU-CGGG-UGAACUAU-GGUUAAGGAACUCGGCAAAA-UGCCCCCG UAACUUCGGG-AGAAGGGGGGC-CA-CA--C-CU-GGUGACG-AG-U------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ACU-C-U----- G-----AGC-U-G--G-GGGUG-GCCGCAGAGACCAGCGAGAAGCGA-----CUGUUUAC UAAAAACACAGGUCCGUGC-GAAGCC--GU---A-A------------GGCGAU-GU-AU ACGGACUG-ACGCCUGCCCGGUGC-U-GGAACGUUAAGGGGACCGGUU-AGUCACAUUUC G-GUGUGGCG-AAGCUGAGAACUUAAGCGCCA-G-UAAACGG-CGGUGGUAACUAUAACC AUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCUCG--ACUGUCUCAA-CC-AUA-GGCCCGGUGAAAUUGCACU-ACGAGUAAA GAUGCUCGUUUCGCGCAGCAGGACGGAAAGA-CCCCG-GGACC-UUUACUACAGUUUGAU AUUGGUGUUCGGUUCGGCUUGUGUAGGAU-AGCUGGGAG-AC-UU-U-GAA--GCU--CG CAC--------------------------------------------------------- ----------------------------------GCCA--GUGUG--GGUGGAGU--CG- UCGU-UGAAAUA-CCAGUCUGGUCGU-GCUGGAUGUCUAA-CCUGG--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUC-AGGGA -CAG-UGUCUGAUGGGUAGUUUAACUGGGGCGGU-UGCCUCCUA-AAGAGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGCCUGGUUGGCAAUCAGGUGUU-GAGUGU-AAGUGCACAA-G GGAGCUUGACUG-UGAGACCG-A----CGGGUCGAGCAGGGACGAAAGUCGGGACU-AGU G-AUCCGGCG-------------------------G---------UGGCU--UGU-GGA- -----------------------------AGCGCCGUCGCUCAACGGAUAAAAGGUACCC CGGGGA-UAACAGGCUGAUCUUCCCCAAGAGUCCAUAUCGACGGGAUGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGCUG --UGC--G-CGU------------------------------------------------ -----AGGAGUC-UUGAGAAGGG--CUGUCCCUAGUACGAGAGGACCGGGACGGACGAAC CUC-UGGUGUG-CCAGU-UGUCCUGCCAAGGGC-AU--GGCUGGUUGGCUA-C-GUUCGG GAG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UGC-UUCGAGA--- --UGAGGAC---------------------------UC--CC---------AC-C--C-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUUGA---------------------------- --------G-GGGU----U--AAGGCU---CCCA--G-UAGACGACUG-GG-UUGAUAGG CCGGA-UCUGGAAG-CAC-C-------------------------GUGA----------- --GGUGU--G--GAGGU-----GACC----G-GUACUAA-UAGGCC-GA---GGG-CUUG -UCCUC-- >Symbiobacterium_thermophilum --AAUCAAGC---U-GGAAAGGGCACAC-GGCGGAUG-CCU-GGGCG-CCA-G--GCGCC GAUGAAGGACGUGGC-AAGCUGCGAUAAGCCUCGGGGAGCCGCAAG-CA-GGCGU-AGAU CCGGGGAUCUCCGAAUGGGGCAACCCGGCUGG-CGUA----------------------- ---------------AU------------------------------------------- ---------------------------------GGCCAGUCA-------------CCC-A CAGCU--------------------------GAAUCCAU-A------------------- ---------------GGCUGUGAGGAGGGC-ACCGCCCGAACUGAAACAUCUCAGUAGGG --CGAGGAAAAGAAAUCAA-CCGAGAUUCCCUCAGU-AGC-GGCGAGCGAACGGGGA-GG AGCCUAAA-CCAGUUCCGGC-----------UG-----------AGCCGGGGCUGGGG-- -------------------------UUGCGGGACGCCGAU-------------------- --GAAGCGAUGCUC--------------C---UGAGCCUAG------CUG-AACAG-GUC UG-GA-------AAGGC------C-GGCC-ACAGAAGGUAAUAGCCCUGUAGGCGAAAGG -C-GAA-GG---------ACC----GCUUGG---CGGAUCCCAAGUACCACGGGACACGA GGAAUCCCGUGGGAAUCCGGGGGGACCA--CCCUCCAAGGCUAAAUACGC--CU-GGCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CGCG-GGAGCGGAGU GAAAGAGACCCUGAAACCGUGUGCCUA-CAA-GCAGU-ACGAGCCCCA-----------U A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAAG-------------------GGUGAGUGCGUGCCUAUUGAAGAAUGAACCGG CGAGUUAC-G----GUCACUGGCAU---GGUUAA-GGG--C-C---------UCA----- -------GGCCC-G-G-A-GCCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAG--------------- -------------------------------------------A-GGGCG---------- -----------------------------------------U------------------ -------------------------AGUCAGUGGCUGUA-GACCCGAAACCCG-GUGAUC UAUCCAUGGCCAGGGUGAAGCGGGG-GUAAGAC-CUCGUGGAGGCCCGA--ACCG-GUCA -GUGUUGAAAAACUGUCGGAUGAGCUGUGGAUAGGGGUGAAAAGCCAAACGAACCGGG-A GAUAGCUGGUUCUCCCCGAAAUAGCUUUAGGGCUAGCGUCGGC-A--------------- ------------------------------------------------------------ -------------------GAGAAGCU-UGCUGGAGGUAGAGC-ACUGAUUGGG--CU-A GG--G-GCC-C-UAU---CGGUUA-CCGAACCCAGUCAAACUCCGAAUGCCAG-CA--A- G-U--------------------------------------------------------- ------------------------------------------------------------ ----------A--UG--G-CCGGC-AGU-CAG-ACG--GC-GAGCGCUAAGGUCCGU-CG -UCAAGA-GGGAA----ACA--GCCCAGACCGCC-AGCUAAG--GUCCC--CAAGUC--U C-U-GC-U-AAG--UGGUC-----------AAGGAUGUGGCGUUGUAGAGACAACCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUGAAAGAGUGCGUAACAGCUCACUGGUC-----G AAUGACGCUGCGCCAUAAAUAC-UCGGGGCU--A-AGCAG---AGC--------ACC--G AAG-CUGCGGA--CUG---C--C------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAG----------------------------- ----------------------------------G-G-C-A-GU-GG--UAGGG----GA ---G-CGUU-CCAUG-U-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGUC-G--A-CCGG-AA-GGA--CGGC-U-GGA-GCGCAU-G--GAAGUGAGAAUGC-C GGUAU-GAGUA-GCG-AA--AA-GACAG-G------------------UGAGAAU----- ----------CCUGUC-CACC-GAA-AGCCU-AAGGAUUCCU-GAGCAAGGCUCGUCCGC UCAGGG------------UCAGUCGGGAC-C-UAA----GCCG-A-GGCCGAA--UGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGGA-AAC-AGG--U CGA----CAUU-CCU----GUACC-A-CC-UA-CGGG-U-C------------------- ----------------------------------------------------G-CUUGAC CGA--------------------------------------------------------- ----------------------------------------UG-CGG-GG-AC--GCAG-G AGGCUA--GG--GGGA-CC-C-GGC--CGC---UGGU----UGA---GC-CGG-G-GU-- -A------AGC------GG-G------U------A---G----C---G-----U----GG C-C------C---GG-UA-G--G-----G--AAG-U-CCG-CCGGG-CU----A-AA--C -GU-G--A-GA-C--G--C-G--A-UG-C-CGA--CC-GAA------------------- ---------AUGAA--------------------------------GU-AGG--GAA--G CC-C----CU-GACGC-CACA---CUGC-CGAGAAA-A-G-CCGC---U--A-GGG---- -A---------------------------------------------------------- -G--AC-C-CGG--GG-U-GCCCGUACCGCAAACCGACACAGGUAGGCG-GGG-AGAGAA -U-CCUCAGG-UG-CG-CGGG-AGAACCCU-CGCUAAGGAACUCGGCAAAA-UGCAUCCG UAACUUCGGG-AGAAGGAUGGC-CC-UCG-A-AC-CGUGAGC-GG-AG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A GA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------C---GCC-G-CA---- G-----AGC-G-G--G-GGAGG-GUUGCAGAGGAGAGGCCCAAGCGA-----CUGUUUAC CACAAACACAGGUCAGUGC-UAAGCC--GG---A-A------------GGCGAC-GU-AU ACUGGCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGGGGAAGGGUC-AGGCU---GCA A----GGCCG-AAGCUCUGAACCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAUGGCGUAACG AC-U--UGGGC--ACUGUCUCGG-CG-AGG-GACCCGGUGAAAUUGCAAU-ACCUGUGAA GAUGCAGGUUACCUGCGAUUGGACAGAAAGA-CCCCAUGGAGC-UUUACUGUAGCCUGGC AUUGGAUUUUGGUGGUGCGUGUACAGGAU-AGGUGGGAG-CC-U--GCGAA--GCC--GG GUC--------------------------------------------------------- ----------------------------------GCCA--GAUUC--GGUGGAGG--CG- CCGU-UGGGAUA-CCACCCUCGCAGC-AUCGAAGUUCUAA-CACAG--GC--------CC C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGGAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GG-G-GCC-GUGGA -CCG-UGCCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCCA-AAAGGUAAC-GGAGG CGCCCAAAGGUCCGCUCAGGAUGGUUGGAAAUCAUCCGUG-GAGUGC-AAAGGCAGAA-G CGGGCUUGACUG-CGAGACAG-A----CAGGUCGAGCAGGGUCGAAAGACGGGCUU-AGU G-AUCCGGCG-------------------------G---------UUCCG--GGU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGCUACCC UGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUCGGGCUGAAGUCGGUCCGAAGGGUUCGGCUGUUCGCCGA UUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCAUCG --CAG--G-CGG------------------------------------------------ -----AGGAGAU-UUGACGGGAU--CUGCCCCUAGUACGAGAGGACCGGGGUGGACGGCC CGC-UGGUGUA-CCAGU-UAUCCCGCCAGGGGU-AC--AGCUGGGUAGCCA-U-GGCCGG AAC-GGAUAAGCGCUGAAAGCAUC--U-AAGCGCGAAGCC------GGC-CCGAAGA--- --UGAGAUC---------------------------UC--CCA--------UC-C--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ----------GGGA---GU--AAGGCC---CCUG--G-AAGAUGACCA-GG-UAGAUAGG CCGGG-AGUGGAAG-UGC-C-------------------------GUAA----------- --GGCAU--G--GAGCG-----GACC----G-GUACUAA-UCGGCC-GA---GGG-CUUG -AUUUC-- >Synechococcus_sp. ----UCAAGC---U-ACAAAGGGCUCAC-GGUGGAUA-CCU-AGGCA-CAC-A--GAGGC GAAGAAGGACGUGGU-UACCGACGAUACGCUUUGGGGAGCCGGAAG-CA-GGCAU-UGAU CCAGAGAUUUCCGAAUGGGGCAACCCUAG-AA-ACAA----------------------- ------------------------------------------------------------ -------------------------------------------------------CUU-A CU-----------------------------GAAUCUAU-A------------------- ---------------GGUAAGUAUGAGCGA-ACGCAGUGAACUGAAACAUCUAAGUAGCU --GUAGGAAGAGAAAGAAA-ACUCGAUUCCCUUAGU-AGC-GGCGAGCGAAGCGGGA-AG AGCCCAAA-CCACCGG--U------------UU-----------UU--ACUGGUGGGG-- -------------------------UUGUGGGAGCGCGAU-------------------- -----AUGGAAU-------C--------U---AGCGAGUAG------ACG-AAUC--ACU UA--A-------GAGGU------G-AACC-GUAGAGGGUGAGAGUCCCGUAGUUGAAACU -U-UAA-GG---------A-U----ACUAGC---GUUAUCCCGAGUAGGCCGGAACACGA GAAAUUCCGGUUGAAUCCACGAGGACCA--CCUCGUAAGGCUAAAUACUCC-UG-UGUGA CCGAUAGU-GAA-G-AGUACCGCGAGGGAAAGGUGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAACAUGAAACCGUGAGCUUA-CAA-GCAAU-UAGAGCACGA----------UU A-------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGAUAGUGUGCCUGUUGAAGAAUGAGCCGG CGACUUAU-A----GGGUCUGGC-A---GGUUAA-GGA--G----------AAUAUA--- ---------UCC-G-A-A-GCCAAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------AG------------------ ------------------------UCGUCAGAUUUUAUA-GACCCGAACCCAG-GUGAUC UAACCAUGUCCAGGAUGAAGCUUAGGU-AACAC-UAAGUGGAGGUCCGA--ACCG-ACUU -CUGUUGAAAAAGGAGCGGAUGAGGUGUGGUUAGGGGUGAAAUGCCAAUCGAACCUGG-A GCUAGCUGGUUCUCCUCGAAAUGUGUUUAGGCGCAGCGGUCAU-G--------------- ------------------------------------------------------------ --------------------AUUA-UA-GUCGGGGGGUAAAGC-ACUGAUUCGG--UG-C GG--G-CUG-C-GAGA--GCGGUA-CCAAAUCGAGUCAAACUCAGAAUACCCG-AU--G- A-A--------------------------------------------------------- ------------------------------------------------------------ -------------CAC-A-UGGCC-AGU-AAG-ACG--GU-GGGGGAUAAGCUUCAU-CG -UCAAGA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--CAAGUC--A A-U-AC-U-AAG--UGGCA-----------AAGGAGGUGGGAAUGCAGAGACAACCAGGA GGUUUGCCUAG-AAGCAGCCAU-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGCGUUCCUGCGCCGAAAAUG-AAUGGGACU--A-AGUAU---UGC--------ACC--G AAG-CUGUGGG--CUU-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAUU---------------------------- -------------------------------UAUA-C-A-A-GC-GG--UAGAG----GA ---G-CGUU-CUGUGGU-------------------AG-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGCAU-U--A-GCGA-GA-GCA--GGUG-U-GGA-CGAAGC-A--GAAGUGAGAAUGU-C GGCUU-GAGUA-GCG-A--AAA-CUAGG-G------------------UGAGAAU----- ----------CCCUAG-CCCC-GAA-AUCCU-AAGGAUUCCU-CCGGAAGGCUCGUCCGC GGAGGG------------UUAGUCGGGAC-C-UAA----GGCG-A-GGCCGAC--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGUU-AAC-AGG--U UAA----UAUU-CCU----GUACC-G-AU-U--GUGA-A-U------------------- -----------------------------------------------------------U GUG--------------------------------------------------------- ----------------------------------------CA-GAG-GG-AC--GGAG-A AGGCUA--AG--U-GU-GC-C-GCA--AGU---UGG------UU---AG-CGG-U-UU-- -A------AGU------AU-U------C-----GA---G----G---U------------ ----GAUGAG---GA-A--C--G---GCG--AAA-A-CGU-UCU------------GA-G -CU-G--A-GG-U--G--C-G--A-AU-A-GGA--GU-UAC------------------- ---------UA-CG--------------------------------GU-AAC--GAA--G AC-A----CU-GAUGU-CCAG---CUUC-CAAGAAA-A-G-CUCU---A-ACCACG-UU- -A---------------------------------------------------------- -A--UU-C-AUA--AU-U-GCCCGUACCCUAAACCGACACAGGUAGGAA-GGU-UGAGUA -U-ACCCAGG-GG-CG-CGAG-AUAACUCU-CUCUAAGGAACUCGGCAAAA-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CA-GC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GCUG-GCCGCAGUGAAGAGAUCCAGGCGA-----CUGUUUAC CAAAAACACAGGUUUCCGC-UAAGUC--GA---A-A------------GACGAU-GU-AU GGGAGCUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGGAAGUAGGUC-AGUCU---AUU C----GUAGG-AAGCUCACGACUGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAACG AU-C--UGGAU--GCUGUCUCGG-AG-AGA-GACUCGGCGAAAUAGGAGU-GUCUGUGAA GAUACGGACUACCUGCACCCGGACAGAAAGA-CCCUAUGAAGC-UUUACUAUAGCCUGGU AUUGGGUUCGGGCCCUGAUUGCGCAGGAU-AGGUGGGAG-AC-UA-U-GAU--CUA--CU CCU--------------------------------------------------------- ----------------------------------UGUG--GGGAG--UAGUGAGU--CA- CUGG-UGAGAUA-CCACUCUAUCAGG-GCUAGGAUUCUAA-CUUUG--AG--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UCA-AC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-CCA-AGAGA -CAG-UAUCAGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCGCAAAGGUUCCCUCAGGCUGGUUGGAAAUCAGCCGCA-GAGUGU-AAAGGCAGAA-G GGAGCUUGACUG-CGAGAGCU-A----CAACUCGAGCAGGUACGAAAGUAGGCCUU-AGU G-AUCCGACG-------------------------G---------UUCCG--CGU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGUUACUC UAGGGA-UAACAGGCUGAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAACCUGGGGCGGUAGUACGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCAUAUCCGGUG --CAG--G-CGU------------------------------------------------ -----AAGAACA-UUGAGAGGAG--CCUUCCUUAGUACGAGAGGACCGGGAAGGACGCAC CGC-UGGUGUA-CCAGU-UAUCGUGCCAACGGU-AA-ACGCUGGGUAGCCA-A-GUGCGG -AGUGGAUAACCGCUGAAAGCAUC--U-AAGUGGGAAGCC------CAC-CUCAAGA--- --UGAGUGU---------------------------UC--UCA--------UG-G--A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUUA----------------------------- --------A-UCCA---GU--AAGGUC---ACGG--G-AAGAAGACCC-GU--UGAUAGG UUCUA-GGUGGAAG-UAC-A-------------------------GUAA----------- --UGUAU--G--UAGCC-----GAGG----A-AUACUAA-CAGACC-GA---GGG-CUUG -UCCUU-- >Synechocystis_sp. --GGUCAAGC---U-ACAAAGGGCUAAC-GGUGGAUA-CCU-UGGCA-CAC-A--GAGGC GAAGAAGGACGUGGU-UACCGACGAAACGCUUCGGGGAGCUGGAAA-CA-AGCAU-UGAU CCGGAGGUGUCCGAAUGGGGCAACCCAAGUGA-ACUA----------------------- ------------------------------------------------------------ -------------------------------------------------------CCC-G CU-----------------------------GAAUAAAAUA------------------- ---------------GGCGGGAGAGAGCAA-ACCUAGUGAACUGAAACAUCUUAGUAGCU --AGAGGAAAAGAAAACAA-AAGUGAUUCUCCAAGU-AGC-GGCGAGCGAACGGGGA-AC AGCCUAAA-CCAAUCU--U------------UU-----------CG--AAGAUUGGGG-- -------------------------UCGUGGGACAGCAAC-------------------- -----GUGGACU-------G--------A---GUAGAUUAG------ACG-AAGC--AGC UG--A-------AAACU------G-CACC-AGAGGAGGUGAAAGUCCUGUAGUCGAAAAU -U-GAA-UC---------A-G----CCUAGC---UGUAUCCCGAGUAGGUCGGAGCUCGU GGAAUUCCGAUUGAAUCAGCCGGGACCA--CCCGGUAAGGCUAAAUACUAC-UG-UGUGA CCGAUAGC-GUA-A-AGUACCGCGAGGGAAAGGUGAAA-AGAAC-CCCGUUGAGGGGAGU GAAAUAGAACAUGAAACCGUUAGCCUA-CAA-GCAAU-GGGAGCUCGA----------UU A-------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AGUGACCGUGUGCCUGUUGAAGAAUGAGCCGG CGACUUAC-A----GGUUGUGGC-A---GGUUAA-GGU--G----------UGUUG---- --------CACC-G-A-A-GCCAAAGUGAAA-GCG------------------------- ---------------------------------------------------------AGC CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------U------------------- ------------------------UAGUCACAAUUUGUA-GACCCGAACCCGG-GUGAUC UAACCAUGGCCAGGAUGAAGCUUAG-GUAACAC-UAAGUGGAGGUCCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGAGCUGUGGUUAGGGGUGAAAUGCCAAUCGAACCCGG-A GCUAGCUGGUUCUCCCCGAAAUGUGUUUAGGCGCAGCGGUUGU-A--------------- ------------------------------------------------------------ -------------------AAGUC-AA-CUUGGGGGGUAAAGC-ACUGUUUCGC--UG-C GG--G-CGG-C-GAGA--GCUGUA-CCAAAGUGAGGCAAACUCAGAAUACCCA-AG--A- A-G--------------------------------------------------------- ------------------------------------------------------------ -------------AA--A-CGACC-AGU-AAG-ACG--GU-GGGGGAUAAGCUUCAU-CG -UCGAAA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--CAAAUC--A U-C-AC-U-AAG--UGAGA-----------AAGGAGGUGGGAGUGCAUUGACAACCAGGA GGUUUGCCUAG-AAGCAGCAAU-CCUUAAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGCGCUCCUGCGCCGAAAAUG-AACGGGGCU--A-AGUGA---UGU--------ACC--G AAG-CUGUGGA--CUC---A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAUA----------------------------- ------------------------------------U-G-A-GU-GG--UAGGG----GA ---G-CGUU-CUGUAUA-------------------GG-G-------------------- ------------------------------------------------------------ ---------------------------------------------------------UGA AGCAC-U--A-GCGGCAA-GCA--GGUG-U-GGA-CAGUAC-A--GAAGUGAGAAUGU-C GGCUU-GAGUA-GCG-A--AAA-UAUGG-G------------------UGAGAAU----- ----------CCCAUA-CCCC-GAA-AUCCU-AAGGGUUCCU-CCGGAAGGCUCGUCCGC GGAGGG------------UUAGUCAGGAC-C-UAA----GGCG-A-GGCCGAG--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-CGG--U CAA----UAUU-CCG----GUACU-G-AU-U--AUAG-A-U------------------- -----------------------------------------------------------U GUG--------------------------------------------------------- ----------------------------------------GC-GGG-GG-AC--GGAG-A AGGCUA--GU--G-CA-AC-U-GGA--AGU---UGG------UU---AC-CAG-U-CC-- -A------AGC------AU-U------C-----GA---G----G---C------------ ----GAUGAG---AG-A--C--G---GCG--AAA-A-CGU-CUU------------GA-G -CA-G--A-GG-U--G--U-G--A-UG-G-GGA--GU-CUC------------------- ---------UA-CG--------------------------------GA-GAC--GAA--G UG-C----AU-GAUGU-CAAG---CUUC-CAAGAAA-A-G-CCCG---A-ACCACG-UU- -A---------------------------------------------------------- -A--UU-U-AUA--GU-C-ACCUGUACCCGAAACCGACACAGGUAGGAA-GGU-AGAGAA -U-ACUAAGG-GG-CG-CGAG-GUAACUCU-CUCUAAGGAACUCGGCAAAA-UUACCCCG UAACUUCGGG-AGAAGGGGUGC-CU-CC--A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------UGGAG-GUCGCAGUGAAUAGGCCCAGGCGA-----CUGUUUAC CAAAAACACAGGUCUCCGC-AAAGUC--GU---A-A------------GACGCA-GU-AU GGGGGCUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGGAAGUUGGUC-AGGGA---GUA A----UCCUG-AAGCUAGCGACUGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAACG AU-C--UGGGC--ACUGUCUCGG-AG-AGA-GGCUCGGCGAAAUAGGAUU-GUCUGUGAA GAUACGGACUCCCUGCACCUGGACAGAAAGA-CCCUAUGAAGC-UUUACUGUAGCUUGGA AUUGGGUUCGGGCUUUGCUUGCGCAGGAU-AGGUGGGAG-AC-UA-U-GAA--GUU--GC UCU--------------------------------------------------------- ----------------------------------UGUG--GGAGU--AAUGGAGU--CA- ACGG-UGAGAUA-CCACUCUGGUGAG-GCUAGAAUUCUAA-CUUGU--UC--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-GAG-AAGGA -CAA-UUUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCGCAAAGGUUUCCUCAGGCUGGUUGGAAAUCAGCCGAA-GAGUGU-AAAAGCAGAA-G GAAGCUUGACUG-UGAGACUG-A----CAAGUCAAACAGGGACGAAAGUCGGCUUU-AGU G-AUCCGACG-------------------------G---------CACUG--AGU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGUUACUC UAGGGA-UAACAGGCUGAUCUCCGCCAAGAGUUCACAUCGACGCGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAACCUGGGGCGGUAGUACGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCAUAUCCGGUG --UAG--G-CGU------------------------------------------------ -----AAGAGUA-UUGAGAGGAG--ACUUCCUUAGUACGAGAGGACCGGGAAGUACGCAC CUC-UGGUGUA-CCUGU-UAUCGUGCCAACGGU-AA-ACGCAGGGUAGCCA-A-GUGCGG -AGUGGAUAACCGCUGAAAGCAUC--U-AAGUGGGAAGCC------CAC-CUCAAGA--- --UGAGUAC---------------------------UC--UCA--------UG-G--U-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUUAA---------------------------- ----------GCCA---GU--AAGGUC---ACGG--G-AAGACUACCC-GU--UGAUAGG CUCUA-GAUGGAAG-UCC-A-------------------------GUAA----------- --UGGAU--G--AAGUC-----GAGG----A-GUACUAA-UAGACC-GA---GGG-CUUG -ACCU--- >Thermoanaerobacter_tengcongensis ----UCAAGA---GAGGUAAGGGCGCAU-GGUGGAUG-CCAUAGGCA-CCU-G--GAGCC GAAGAAGGACGCGGC-AAGCGGCGAAACGCCCCGGGGAGCCGCAAG-CA-GGCAG-AGAU CCGGGGAUUUCCGAAUGGGGGAACCCGCUUGG-GGUA----------------------- ---------------AU------------------------------------------- ---------------------------------ACCCAAGCA-------------UCC-G CUGAU--------------------------GAAUCCAU-A------------------- ---------------GUCAGC-GGAGGGGA-ACCGGGCGAACUGAAACAUCUAAGUAGCC --CGAGGAAAAGAAAGCAA-AAGCGAUUCCCUAAGU-AGC-GGCGAGCGAAAGGGGA-GA AGCCCAAA-CCUACC---GC-----------UUAGGCG------G------UAGGGG--- -------------------------UUCGGGCCCACCGA--------------------- -----GAGGUGU-----GUG--------A---GUACUCUAG------GCG-AACGG-ACC UG-GA-------AAGGC------C-GGCC-AAAGAGGGUGAAAGCCCCGUAGCCGAAAGG -G-GAA-AG---------CGC----ACAGGU---GGGUACCAGAGUACCACGGGAUAGGC G--ACCCUGUGGGAAGGAGGGAGGACCA--CCUCCUAAGGCUAAAUACUC--CA-GGUGA CCGAUAGC-GCA-U-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCG-GGAGGGGAGU GAAAUAGAACCUGAAACCAUGUGCCCA-CAA-GCAGU-CAGAGUCCGG----------CA CUCAACCUAGUGUUUACUGGGUGAAUAGAGUAAG--AGGGAUAGAAAGAGG--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AGAAGUAGUUAAG-AGAAGAG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAAGCACUA-AGUUGAGUGCCG-GAUGAUGGCGUACUUUUUGCAGAACGGGCCGG CGAGUUAU-G----GUAGCGAGCGA---GGUUAA-GGG--U-A--------GAGA----- -------UACCC-G-G-A-GCCGAAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAG--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------GG------------------ ------------------------AAGUUCGCUGCCAUA-GACCCGAAACCGU-GCGACC UACCCAUGGCCAGGGUGAAGCCGGA-GUAAGAU-CUGGUGGAGGCCCGA--ACCC-GUUG -GCCGUGAAAAGCCAUGGGAUGAGCUGUGGGUAGCGGUGAAAUGCCAAUCGAGCACGG-A GAUAGCUGGUUCUCCCCGAAAUAGCUUUAGGGCUAGCCUCAGG-G--------------- ------------------------------------------------------------ --------------------UAAA-GC-CUGUGGAGGUAGAGCGACUGACUGGG--CU-A GG--G-GCC---GAGA---GGCUA-CCGAACCCUAUCAAACUCCGAAUGCCAC-AG--G- C-A--------------------------------------------------------- ------------------------------------------------------------ ---------AG--UA--C-CUGGG-AGU-CAG-ACC--AC-GAGUGAUAAGAUCCGU-GG -UCGAGA-GGGGA----ACA--GCCCAGACCUCC-AGCUAAG--GUCCC--GAAGGG--C A-U-GU-U-AAG--UGGGA-----------AAGGAAGUGGGACUUCGAAGACAACCGGGA UGUUGGCUUAG-AAGCAGCCAUACAUUUAAAGAGUGCGUAACAGCUCACCGGUC-----G AGAGGUCCUGCGCCGAAAAUGAAC-GGGGCUC-A-AACAU---GCC--------ACC--G AAG-CUGGGGC--UGC---G--C------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ----------------------------------G-C-G-C-GG-GG--UAGGG----GA ---G-CGUA-CUGCG-C-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGGCU-G--A-GCGU-AA-GCG--GAGC-U-GGA-CUGCGC-A--GUAGAGAGAAUGC-C GGCAU-GAGUA-GCG-A---GA-GUAAG-G------------------UGAGAAA----- ----------CCUUAC-CGCC-GGA-AGCCU-AAGGAUUCCU-GGGGAAGGGUCGUCCAC CCAGGG------------UAAGUCGGGGC-C-UAA----GCCG-A-GGCCGGA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------GC---GA--U-GGGA-AAC-CGG--U AGA----GAAU-CCG----GUACC-A-CC-GA--GGG-C-C------------------- ----------------------------------------------------G-CAUGAG GGA--------------------------------------------------------- ----------------------------------------AG-UGG-GG-AC--GCAG-C GAGGUA--GG--CGGA-GC-G-CGC--GGU---UGGU----AGA---GC-GCG-U-CC-- -A------ACC------AG-A------C------AC--C----G---G-----A----GG G-C------A---CG-UA-G--G-----C--AAA-U-CCG-CGUGC-CG------GC--A -GG-G--G-GC-U--G--G-G--A-AG-G-GGA--GC-C--------------------- ---------GG-AA-----------------------------------GGC--GAA--G CC-G----CU--A-AG-AACG---CUGC-CAAGAAA-A-G-CCGC---U--A-CCG---- -A---------------------------------------------------------- -G--GC-C-UGA--GG-U-GCCCGUACCGCAAACCGACACAGGUAGGCG-AGG-AGAGAA -U-CCACAGG-CG-AG-CGGG-AGAACCCU-CCUUAAGGAACUCGGCAAAA-UGACUCCG UAACUUCGGG-AGAAGGAGUGC-C------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------G-GCCGCAGAGAAGAGGCCCAAGCGA-----CUGUUUAC CAAAAACACAGGUCUCUGC-UAAGCC--GA---A-A------------GGCGAA-GU-AU AGGGGCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGGGGAAGGGU----------GUA G------------GCUCUGAACCGAAGCCCCA-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAAGGCGUAACG AC-U--UGGGC--GCUGUCUCGA-GG-AGG-GGCCCGGCGAAGUUGUAGU-GCUCGUGAA GAUGCGAGCUACCCGCGAUUGGACGGAAAGA-CCCCGUGGAGC-UUUACUGUAGCCUGUC ACUGGACACUGGUAGUCUCUGUACAGGAU-AGGUGGGAG-AC-UG-A-GAA--GGU--GG CGC--------------------------------------------------------- ----------------------------------GCCA--GCGUC--ACUGGAGU--CG- GCGU-UGGGAUA-CCACCCUGAGACU-AGUGGGGUUCUAA-CCUUA--AG--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-CUA-AGGGA -CAA-UGGCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCCCAAAGGUCCCCUCAGCGCGGACGGGAAUCGCGCGAA-GAGUGC-AAAGGCAGAA-G GGGGCUUGACUG-UGAGAGAG-A----CAUCUCGAGCAGGGACGAAAGUCGGGCUU-AGU G-AUCCGGCG-------------------------G---------CAGUG--AGU-GGG- -----------------------------AACGCCGUCGCUCAACGGAUAAAAGCUACCC CGGGGA-UAACAGGCUGAUCUCCCCCAAGAGUCCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGAAGUAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCG --CGG--G-CGC------------------------------------------------ -----AGGAGAC-UUGAGGGGAG--CCAUCCCUAGUACGAGAGGACCGGGAUGGACGAGC CGA-UGGUGUA-CCAGU-UGCACCGCCAGGUGC-AC--AGCUGGGUAGCCA-A-GCUUGG AAG-GGAUAAACGCUGAAAGCAUC--U-AAGCGUGAAGCC------CAC-CCCAAGA--- --UAAGGUC---------------------------UC--CCA--------CC-C----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- -----------GGG---GU--AAGGCA---CCUU--G-UAGAAGACGA-GG-UAGAUAGG CCGGG-GGUGUAAG-AGC-G-------------------------GAAA----------- --CGCUU--U--UAGCU-----GACC----G-GUACUAA-UAAGCC-GA---GGA-CUUG -ACCCU-- >Thermosynechococcus_elongatus --GGUCAAGC---U-ACAAAGAGCCUAC-GGUGGAUA-CCU-AGGCA-CAC-A--GAGGC GAUGAAGGACGUGGA-UACCGACGAUACGCUUCGGGGAGCUGGAAA-CA-AGCUU-UGAU CCGGAGGUCUCCGAAUGGGGCAACCCAGUAAC-UCUA----------------------- ---------------AC------------------------------------------- -------------------------------------------------------GCC-A -------------------------------AUCCAUAA--------------------- ------------------UUAGAGG-GCGA-ACCUGGCGAACUGAAACAUCUUAGUAGCC --AGAGGAAAAGAAAGAAA-ACUCGAUUCCCUUAGU-AGC-GGCGAGCGAAAGGGGA-AC AGCCUAAA-CCAACGG--G------------CU-----------UG--CCCGUUGGGG-- -------------------------UCGUGGGACAGCAAC-------------------- -----AUGGAAU-------U--------G---GGCGGCUAG------ACG-AAGU--AGU GG--A-------AUGCU------A-CACC-AGAGAAGGUGAAAGUCCUGUAGUCGAAAGC -U-UAA-CA---------A-U----CCUAGC---UGUAUCCCGAGUAGUCCGGAGCACGU GGAAUUCCGGAUGAAUCUGCGAGGACCA--CCUCGUAAGGCUAAAUACUCC-UG-UGUGA CCGAUAGC-GCA-U-AGUACCGCGAGGGAAAGGUGAAA-AGAAC-CCCGG-AAGGGGAGU GAAAUAGAGCAUGAAACCGUAGGCUUA-CAA-GCAGU-CGAAGCUCGA----------UU U-------------------------------------------AACG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AGUGACGGCGUGCCUGUUGAAGAAUGAGCCGG CGACUUAU-A----GGUACUGGC-A---GGUUAA-GGC-------------AAAAA---- --------UGCC-G-A-A-GCCAUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------U------------------- ------------------------UUGUCAGUACUUAUA-GACCCGAACCCGG-GUGAUC UAACCAUGGCCAGAAUGAAGCUUGGGU-AACAC-CAAGUGGAGGUUCGC--ACCG-ACCG -AUGUUGAAAAAUCGGCGGAUGAGCUGUGGUUAGGGGUGAAAUGCCAAUCGAACCCGG-A GCUAGCUGGUUCUCCCCGAAAUAUGUUGAGGCAUAGCGGUUGU-G--------------- ------------------------------------------------------------ --------------------AUUA-UA-GCAGGGGGGUAAAGC-ACUGAUUCGG--UG-C GG--G-CUG-C-GAGA--GCGGUA-CCAAAUCGAGUCAAACUCUGAAUACCCU-GUG-U- A-C--------------------------------------------------------- ------------------------------------------------------------ -------------AC--A-CAGCC-AGU-CAG-ACG--GU-GGGGGAUAAGCUUCAU-CG -UCGAGA-GGGAA----ACA--GCCCAGACCACC-AGCUAAG--GUCCC--CAAAUC--A U-C-AC-U-AAG--UGGCA-----------AAGGAGGUGGGGAUGCUCAGACAACCAGGA GGUUUGCCUAG-AAGCAGCCAU-CCUUAAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGCGUUCCUGCGCCGAAAAUG-AACGGGACU--A-AGUGA---UGU--------ACC--G AAG-CUGUGGA--CUU---A--C------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UACG----------------------------- ------------------------------------U-A-A-GU-GG--UAGGG----GA ---G-CGUU-CUGCACU-------------------AG-U-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCAC-U--A-GCGU-AA-GCA--GGUG-U-GGA-CGAAGC-A--GAAGUGAGAAUGC-C GGCUU-GAGUA-GCG-A--AAA-CAUUG-G------------------UGAGAAU----- ----------CCAAUG-CCCC-GAA-ACCCC-AAGGGUUCCU-UCGGAAGGCUCGUCCGC GAAGGG------------UUAGUCGGGAC-C-UAA----GGCG-A-GGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-UGG--U CAA----UAUU-CCA----GUACU-C-AU-C--UUGG-U-U------------------- -----------------------------------------------------------U GUG--------------------------------------------------------- ----------------------------------------CA-GAG-GG-AC--GAAG-A AGGCUA--GA--U-CA-GC-C-GGA--UGU---UGG------UU---AC-CGG-U-UC-- -A------ACU------GU-C------C-----GA---G----G---U------------ ----GUUGAG---GA-G--C--G---GUG--AAA-A-CGC-UCU------------GA-G -CU-G--A-GG-C--A--G-G--A-GU-A-CGA--CC-CAC------------------- ---------UA-CG--------------------------------GU-GGG--GAA--G UG-A----UU-GAUGU-CAUG---CUUC-CAAGAAA-A-G-CUCU---A-AGCACG-UU- -A---------------------------------------------------------- -A--GC-C-A-A--GA-U-ACCCGUACCCGAAACCGACACAGGUGGGGG-GGU-AGAGUA -U-ACCAAGG-GG-CG-CGAG-AUAACUCU-CUCUAAGGAACUCGGCAAAA-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CA-CC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GGUG-GUCGCAGUGAAGAGGCCCAGGCGA-----CUGUUUAC CAAAAACACAGGUCUCCGC-UAAGUC--GU---A-A------------GACGAU-GU-AU GGGGGCUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGGAAGCCGGUC-AGC-----GCA A------GCG-AAGCUGGCGACCGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAAGGCGUAACG AU-C--UGGGC--GCUGUCUCGG-AG-AGA-GGCUCGGCGAAAUAGAAGU-GUCUGUGAA GAUGCGGACUACCUGCACCCGGACAGAAAGA-CCCUAUGAAGC-UUUACUGUAGCCUGGA AUUGGGUUCGGGCUUUGCUUGCGCAGGAU-AGGUGGGAG-AC-GU-U-GAA--GUA--UC CCU--------------------------------------------------------- ----------------------------------UGCG--GGGGA--UAUGGAGU--CG- CCAG-UGAGAUA-CCACUCUGGCAAG-GCUAGAAUUCUAA-CCUUC--UG--------CU G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAGC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CA-G-CGA-AGGAA -CAG-UUUCAGGUGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAUGGUAAC-GGAGG CGCGCAAAGGUUCCCUCAGGCUGGUCGGAAAUCAGCCGUA-GAGUGC-AAAGGCAUAA-G GGAGCUUGACUG-CAAGACCU-A----CAAGUCGAGCAGAGACGAAAGUCGGCCUU-AGU G-AUCCGACG-------------------------G---------UUCCG--CGU-GGA- -----------------------------AGGGCCGUCGCUCAACGGAUAAAAGUUACUC UAGGGA-UAACAGGCUGAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUC GAUGUCGGCUCAUCGCAACCUGGGGCGGUAGUACGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCAUAUCCGGUG --CAG--G-CGU------------------------------------------------ -----AGGAGCA-UUGAGAGGAG--UCCUCCUUAGUACGAGAGGACCGGGAGGAACGCAC CUC-UGGUGUA-CCUGU-UAUCGUGCCAACGGU-AA-ACGCAGGGUAGCCA-U-GUGCGG -AGUGGAUAACCGCUGAAAGCAUC--U-AAGUGGGAAGCC------CAC-CUCAAGA--- --UGAGUGC---------------------------UC--CCA--------UG-G--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUAA----------------------------- ----------GCCA---GU--AAGGUC---ACGG--G-UAGAACACCC-GU--UAAUAGG CUCCC-GAUGGAAG-UCC-A-------------------------GUAA----------- --UGGAU--G--AAGUC-----UAGG----A-GUACUAA-UAGACC-GA---GGG-CUUG -ACCUC-- >Thermotoga_maritima --GGUCAAGG---U-ACUAAGGGCACGC-GGUGGAUG-CCU-UGGCG-GCG-G--GAGGC GAUGAAGGGCGUGGC-AAGCUGCGAUAAGCCCGGGGGAGCCGCAAG-CA-GGCGU-UGAU CCCGGGAUUCCCGAAUGGGGAAACCUGGGUGGCCGUU----------------------- ---------------GA------------------------------------------- ---------------------------------GGCCACU---------------CGC-C GCC----------------------------G-AAA------------------------ ---------------GG---CGGUG--CGACACCGGGGGAAGUGAAACAUCUCAGUACCC --CGAGGAAAAGAAAUCAA-CCGAGAUUCCCCUAGU-AGC-GGCGAGCGAACGGGGA-GG AGCCCAAA-CCAGCGUGGUGUCA-AAGCCC-GUGGGCG------UUGCCACGCUGGGG-- -------------------------UUGUGGGACACGGCCGGGCGA----GGCCACGGAC UCGCCGGGGAGUUACAAAUC--------C---CUCCUCUAG------CCG-AACC--ACC UG-GG-------AAGGU------G-GGCC-GGAGAGGGUGACAGCCCCGUAGGCGAAAGG -G-GAG-GG---------ACU----CCCUGGGCCGUGCUCCCGAGUACCACGGGACACGU GGAAUCCCGUGGGAAGCUGGGGGGACCA--CCCUCCAAGGCUAAAUACUAC-CC-GCCGU CCGAUAGC-GCACC-AGUACCGUGAGGGAAAGGUGAAA-AGCAC-CCCG-GAAGGGGAGU GAAAGAGGACCUGAAACCGCGUGCCUA-CAA-GAAGU-CGGAGCCCCC------------ ------------------------AUUU-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGACGGCGUGCCUUUUGAUUAAUGAGCCCG CGAGUUGC-C----GUCGGUGGCGA---GGUUAA-GCC--G-----------ACGA---- --------AGGC-G-U-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAC--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------CU------------------- ------------------------CAGUCACCGGCGGCA-GACCCGAAGCCGG-GUGAGC UACCCCUGGGCAGGGUGAAGGUGGG-UUAAAAC-CCACUGGAGGCCCGA--ACCG-GUGG -ACAGUGAAAAGUCCUCGGAUGACCUGGGGGUAGGAGUGAAAAGCUAACCGAACCCGG-U GAUAGCUGGUUCUCCCCGAAAUGCAUUGAGGUGCAGCCUCGGG-C--------------- ------------------------------------------------------------ --------------------GGUC-UG-UGCAGGGGGUAGAGC-ACUGAUGGGG--CU-A GG--G-GG-----GUU----UCCU-CCGAACCCCGUCAAACUCCGAAUCCCUG-CA--C- A-C--------------------------------------------------------- ------------------------------------------------------------ ---------AA--AG--C-CCGGG-AGU-GAG-CCC--GC-GGGGGAUAAGCUCCGC-GG -ACGAGA-GGGGA----ACA--ACCCAGACCGCC-GGCUAAG--GGCCC--GAAGAG--G U-G-GC-U-AAG--UGGUA-----------AAGGAUGUGGAGCGCCUAAGACAGCUGGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAGUGCGUAACAGCUCACCAGCC-----G AGGCGCUCUGCACCGAAAAUGUAACGGGGCUC-A-AGCCA---CCC--------CCC--G AAG-CCGCGGG--UCA---G--U----AC-C---------------UC-C---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCU------------------------------ ---------------GG----A---------GGUA-C-U-G-GC-GG--UAGGG----GA ---G-CUUU-CCGCUGU-------------------AG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGCG-G-AC-CCGC-GA-GGG--CCGC-U-GGA-CGAGGC-G--GAAGUGAGAAUGC-G GGCAU-GAGUACGCG-A---AA-GGAGG-G------------------UGAGAAU----- ----------CCCUCC-CCCC-GUA-AGCCC-AAGGGUACCU-GGGGAAGGUUCGUCCGC CCAGGG------------UUAGCCGGGAC-CCUAA----GGUG-A-ACCCGAA--AGGGG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--A-GGGA-AGC-CGG--U UAA----UAUU-CCG----GCGCC-A-CC-U--GCGG-U-C------------------- ------------------------------------------------------GAUGGU ACG--------------------------------------------------------- ----------------------------------------AG-GGG-UG-AC--GCAG-G AGGGUA--GG--C-GCCGG-G-GGC--AAG---UGG-----CAU---GC-CCC-U-CC-- -A------AGC------GG-U------U------AG-GGC---G--AU-----G----AC G-G------G---CG-UA-G--G-----U--AAA-U-CCG-CGCCC-CG------A---G CCU-G--A-GC-C--G--U-G--A-UG-G-GGA--GG-UCCC------------------ ---------UU-CG-----------------------------G--GG-ACC--AAC--G GC-G----CU-GACCC-CACA---CUGC-CGAGAAA-A-A-CCUC---G--C-GUA-CC- GCUUGA------------------------------------------------------ -G--AC-C-GUA--GG-U-GCCCGUUCCGCAAACCGACACAGGUGGGCG-GGC-UGAGAA -G-GCUCAGG-GG-AG-CGGG-UUAACCCU-CGCCAAGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CG-CG-UU-AG-GGUGAAC-CC-AG-GGGAAGGG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CCC-GGA-AAC---UGG-G-G----- G-----AGC-C-C--G-AGGCG-GUCGCAGUGACAAGGCCCUGGCGA-----CUGUUUAC CAAAAACACAGGUCUCUGC-UAACUC--GA---AAA------------GAGGAA-GU-AU AGGGACUG-ACGCCUGCCCAGUGC-C-GGAAGGUUAAGGGGAGGGGUGAGGCUCCC-CUU GU-GGGAGCG-UAGCUCCGACCCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCAUGAAUGGCGUAACG AC-U--GGGGC--ACUGUCUCGG-CG-GGG-GGCCCGGCGAAAUUUCAGU-CUGGGUGAA GAUGCCCAGUACCCGCGGCUAGACGGAAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGGU AUUGGGCUCUGGUGCAUCGUGUAUAGCAU-AGGUGGGAG-GC-UG-U-GAA--GCC--GC CUC--------------------------------------------------------- ----------------------------------GCCA--GGGGC--GGUGGAGC--CG- CCA-GUGGAAUA-CCACCCUCGGUGC-ACUGGAGUCCUAA-CCUGA--CC--------CU GU---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GAAGA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------G-CA-G-GGU-GGGGA -CAG-UGCCAGGUGGGCAGUUUGACUGGGGCGGU-CACCUCCUA-AAAGGUAAC-GGAGG UGUGCAAAGGUCGGCUCAGGUGGGUUGGAAAUCCACCGCA-GAGUGC-AAGGGCAUAA-G CCGGCCUGACUG-CGAGGCCG-A----CAGGCCGAGCAGGGGGGAAACCCGGCCCU-AGU G-ACCCGGCG-------------------------G---------UCCCG--UGU-GGA- -----------------------------AGGGCCGUCGAUCAACGGAUAAAAGUUACCC CGGGGA-UAACAGGCUGGUCCCGCCCGAGAGUUCACAUCGACGGCGGGGUUCGGCACCUC GAUGUCGGCUCAUCCCAUCCUGGGGCUGAAGCAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGGGGUACGUGAGCUGGGUUCAGACCGUCGUGAGACAGGUCGGUCCCUAUCUGCCG --CGG--G-CGU------------------------------------------------ -----AGGAGGC-UUGAGGGGGG--UCCUCCCUUGUACGAGAGGACCGGGAGGAGGGGGC CUC-UGGUGUA-CCGGC-UGUCGCGCCAGCGGC-AUA-CGCCGGGUAGCUA-C-GCCCCU AAG-CGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCG------CGC-CCCAAGA--- --UUAGGCC---------------------------UC--CCA--------UC-C--C-- G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- --------A-GGGA---GU--AAGGCC---GGUC--C-GAGAAGAGGA-CC-UUGAUAGG CCGGG-GGUGUAAG-CGC-C-------------------------GCAA----------- --G-CGU--U--GAGCC-----CACC----G-GUACUAA-UCGGCC-GA---GGC-CUUG -ACCUC-- >Thermus_thermophilus --GGUCAAGA---U-GGUAAGGGCCCAC-GGUGGAUG-CCU-CGGCA-CCC----GAGCC GAUGAAGGACGUGGC-UACCUGCGAUAAGCCAGGGGGAGCCGGUAG-CG-GGCGU-GGAU CCCUGGAUGUCCGAAUGGGGGAACCCGGCCGGCGGGA----------------------- ---------------A-------------------------------------------- ---------------------------------CGCCGGUCA-------------CCG-C GCU------------------------------UU------------------------- ----------------UGCGCGGGG--GGA-ACCUGGGGAACUGAAACAUCUCAGUACCC --AGAGGAGAGGAAAGAGA-AAUCGACUCCCUGAGU-AGC-GGCGAGCGAAAGGGGA-CC AGCCUAAA-CCGUCCG--GC-----------UU-----------GU--CCGGGCGGGG-- -------------------------UCGUGGGGCCCUCG------------------GA- ----CA-------CCGAAUC--------C---CCAGCCUAG------CCG-AAGC--UGU UG-GG-------AAGCA------G-CGCC-AGAGAGGGUGAAAGCCCCGUAGGCGAAAGG -U-GGG-GG---------GAU----AGGUGA---GGGUACCCGAGUACCCCGUGGUUCGU GGAGCCAUGGGGGAAUCUGGGCGGACCA--CCGCCUAAGGCUAAGUACUC--CG-GGUGA CCGAUAGC-GCACC-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCG-GGAGGGGAGU GAAAUAGAGCCUGAAACCGUGGGCUUA-CAA-GCAGU-CACGGCCCCG----------C- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUUGUGGCGUGCCUAUUGAAGCAUGAGCCGG CGACUCAC-G----GUCGUGGGCGA---GCUUAA-GCC--G-----------UUG----- --------AGGC-G-G-A-GGCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CCG---------------------------------------AAC--------------- -------------------------------------------A-GGGCGCAA--GCGGG CC-G-----------------------------------CACG----------------- ---------CG-G-CCC-GC---AAAGUCCGCGGCCGUG-GACCCGAAACCGG-GCGAGC UAGCCCUGGCCAGGGUGAAGCUGGG-GUGAGAC-CCAGUGGAGGCCCGA--ACCG-GUGG -GGGAUGCAAACCCCUCGGAUGAGCUGGGGCUAGGAGUGAAAAGCUAACCGAGCCCGG-A GAUAGCUGGUUCUCCCCGAAAUGACUUUAGGGUCAGCCUCAGG-C--------------- ------------------------------------------------------------ --------------------GCUG-AC-UGGGGCCUGUAGAGC-ACUGAUAGGG--CU-A GG--G-GGC---CCACCA-GCCUA-CCAAACCCUGUCAAACUCCGAAGGGUCC-CAG-G- U-G--------------------------------------------------------- ------------------------------------------------------------ ----------G--AG--C-CUGGG-AGU-GAG-GGC--GC-GAGCGAUAACGUCCGC-GU -CCGAGCGCGGGA----ACA--ACCGAGACCGCC-AGCUAAG--GCCCC--CAAGUC--U G-G-GC-U-AAG--UGGUA-----------AAGGAUGUGGCGCCGCGAAGACAGCCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUGCGUAAUAGCUCACUGGUC-----G AGUGGCGCCGCGCCGAAAAUGAU-CGGGGCUU-A-AGCCC---AGC--------GCC--G AAG-CUGCGGG--UCU---G--G----GG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAUGA---------------------------- --------------------------------CCC-C-A-G-GC-GG--UAGGG----GA ---G-CGUU-CCCGAUG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGCC-G-AC-CCGC-GA-GGG--CGGC-U-GGA-GGUAAG-G--GAAGUGCGAAUGC-C GGCAU-GAGUA-ACG-A--UAA-AGAGG-G------------------UGAGAAU----- ----------CCCUCU-CGCC-GUA-AGCCC-AAGGGUUCCU-ACGCAAUGGUCGUCAGC GUAGGG------------UUAGGCGGGAC-C-UAA----GGUG-A-AGCCGAA--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA--A-GGGC-AGC-CGG--U UAA----UAUU-CCG----GCCCU-U-CC-C--GCAG-G--------------------- ---------------------------------------------------------UGC GAU--------------------------------------------------------- ----------------------------------------GG-GGG--G-AC--GCUC-U AGGCUA--GG--G-GGACC-G-GAG--CCA---UGGA----CGA---GC-CCG-G-CC-- -A------GAA------GC-G------C----------A----G---G-----G----UG G-G------A---GG-UA-G--G-----C--AAA-U-CCG-CCUCC-CA-----ACAAGC UCU-G--C--G-U--G--G------UG-G-GGA--AG-CCC------------------- ---------GU-ACG-------------------------------GGUGAC--AAC--- CC-C----CC-GAAGC-CAGG---GAGC-CAAGAAA-A-G-CCUC---U--A-AGC-A-- CA-A-------------------------------------------------------- ----CC-U-GCG--GG-A-ACCCGUACCGCAAACCGACACAGGUGGGCG-GGUGCAAGA- -GCACUCAGG-CG-CG-CGGG-AGAACCCU-CGCCAAGGAACUCUGCAAGU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-UC-CC--U-GG-GGU---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GA UG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GC-C-C--C-GGGGA-GCCGCAGUGAACAGGCUCUGGCGA-----CUGUUUAC CAAAAACACAGCUCUCUGC-GAACUC--GU---A-A------------GAGGAG-GU-AU AGGGAGCG-ACGCUUGCCCGGUGC-C-GGAAGGUCAAGGGGAGGGGU----------GCA A------------GCCCCGAACCGAAGCCCCG-G-UGAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAAAGCGUAACG AC-C--GGAGC--GCUGUCUCGG-CG-AGG-GACCCGGUGAAAUUGAACU-GGCCGUGAA GAUGCGGCCUACCCGUGGCAGGACGAAAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGGU GUUGGCUCUUGGUCGCGCCUGCGUAGGAU-AGGUGGGAG-CC-UG-U-GAA--CCC--CC GCC--------------------------------------------------------- ----------------------------------UCCG--GGUGG--GGGGGAGG--CG- CCGG-UGAAAUA-CCACCCUGGCGCG-GCUGGGGGCCUAA-CCC-U--C----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGAU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GG-GGGGA -CAG-CGCUUGGCGGGCAGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG CGCCCAAAGGUCCCCUCAGGCGGGACGGAAAUCCGCCGGA-GAGCGC-AAGGGUAGAA-G GGGGCCUGACUG-CGAGGCCU-G----CAAGCCGAGCAGGGGCGAAAGCCGGGCCU-AGU G-AACCGGUG-------------------------G---------UCCCG--UGU-GGA- -----------------------------AGGGCCAUCGAUCAACGGAUAAAAGUUACCC CGGGGA-UAACAGGCUGAUCUCCCCCGAGCGUCCACAGCGGCGGGGAGGUUUGGCACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGAAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGCACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCUCUAUCCGCCA --CGG--G-CGC------------------------------------------------ -----AGGAGGC-UUGAGGGGGG--CUCUUCCUAGUACGAGAGGACCGGAAGGGACGCAC CUC-UGGUUUC-CCAGC-UGUCCCUCCAGGGGC-AUA-AGCUGGGUAGCCA-U-GUGCGG AAG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------CGC-CCCAAGA--- --UGAGGCC---------------------------UC--CCA--------CG-G--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUCA----------------------------- --------A-GCCG---GU--AAGGAC---CCGG--G-AAGACCACCC-GG-UGGAUGGG CCGGG-GGUGUAAG-CGC-C-------------------------GCGA----------- --GGCGU--U--GAGCC-----GACC----G-GUCCCAA-UCGUCC-GA---GGU-CUUG -ACC---- >Treponema_pallidum --------GC---GA-AUAGUGGUUUAC-GGUGGAUG-UCU-UGGAG-UUG-U--CAGGC GAUGAAGGUCGUGAU-AAGCUGCGAAAAGCCUCGGGGAGGAGCACA-UG-UCCUGU-GAU CCGGGGAUGACCGAAUGGGGUAACCCGACAGGGUAAA-------------G--C------ ------------------------------------------------------------ -----------------------------------CUUGUCA-------------UUGCC UUCCU--------------------------GAAUGAAU-A------------------- ---------------GGGAGGGUAAGGCGAAACUGGGUGAACUGAACCAUCUAAGUAACU --UG-GGAAAAGAAAUCAA-GAGAGAUUCCGAAAGU-AGU-GGCGAGCGAAAUUGG-AGG AGCCUAAA-CC-U-G------------------------------UGUCUAACAGGGG-- -------------------------UUGUAGGGCCGCGCGGG---C--------UUGCG- --UUCGGUGGGUGAAAUAAU-------CC---GGCCUAUAG------CAG-AAAGG-UUU UG-GG-------AAAGC------C-UGAC-AGAGAGGGUGAAAUCCCCGUAUGCGGAAUG -G-GGC-GG---------ACC----UGCUG-GUGCGGUACCUGAGUACGGCGGGACACGA GGAAUCCUGUCGGAAUCUGGGUCGACCA--CGAUCUAAGGCUAAAUACUCG-AC-AACUA CCGAUAGU-GGACA-AGUACCGUGAGGGAAAGAUGAAA-AGAAC-CCCGGUGAGGGGAGU GAAAUAGAACCUGAAACCGUAAACCAA-CAA-GAUGU-UACAGCCUGU----------G- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------A--G----GGUGGUAGCGUGCCUUUUGUAGAAUGAGCCUG CGAGUUAC-G----GUGUGCAGCAA---GGUUAA-GGG--A-U---------AGGA---- -------GUCCU-G-G-A-GCCGGAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAA--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------UGGU----------------- ------------------------GAGUUGUACGUCGUA-GACCCGAAGCCAGGGUGAUC UAGUUAUGAGCAGGUUGAAACAGGG-GUGAAGC-CUUGUGGAGGACCGA--ACUA-UAAU -CUGUUAAAAAAGGUAUGGAUGACUUGUGACUAGGAGUGAAAGGCUAAACAAACCUGG-A GAUAGCUGGUUCUCCCCGAAAUGCCUUUAGGGACAGCCUUAUA-C--------------- ------------------------------------------------------------ ---------------------AAA-AC-UGUCGGAGGUAAAGC-ACUGGAUGGG--CU-A GG--G-GGU-U-UCAU--CGCCUA-CCAAACCCAAUCAAACUCUGAAUGCCGG-CA--G- U-C--------------------------------------------------------- ------------------------------------------------------------ ---------AA--CG--U-GUGGG-AGU-GAG-ACU--GC-GUGCGACAAGGUUCGU-AG -UCGAGA-GGGAA----ACA--GCCCAGACCGUC-AGCUAAG--GUCCC--GAAA-U--A C-C-GCUU-GAG--UGUGA-----------AAUGAAGUGUGGGUACCUGGACAGCCAGGA GGUUGGCUUAG-AAGCAGCCAUUCCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----G AGUACGCAUGCGCAGAUAAUGUAUCGGGGCU--A-AGCGG---UAU--------ACC--G AAG-CUACGGG--UCU---U--G----CA-U---------------U------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUU------------------------------ ---------------------G---------GUGC-A-A-G-GC-GG--UAGGG----GA ---G-CAUU-CCAUGUA-------------------CU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AUGA AGGAA-U-AU-CCGG-GA-GGA--GUUC-U-GGA-GGGGAU-G--GAAGAGAGAAUGC-A GGUAU-AAGUACACG-A--AAA-GGAGG-G------------------UGAGAUU----- ----------CCUUCC-CGCC-GAA-AACCU-AAGGUUUCCU-GGGUGAAGGUCAUCUGC UCAGGG------------UAAGUCGGCCC-C-UAA----GGCG-A-GGACGAG--GGUCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AUC-CGG--U UUA----UAUU-CCG----GAACC-U-CU-U--GCAA-U-U------------------- -----------------------------------------------------------U CGA--------------------------------------------------------- ----------------------------------------UG-GCA-GG-AC--GCGU-G AGGUGAA-GC--C-CG-GC-C-AAA--GAU---UGGU----AGU---UU-UGG-U-CU-- -A------AGU------AU-C------C---GAGC--CG---UU--UU-----A----AG A-G------C---GA-UA-G--G-----C--AAA-U-CCG-UCGUU-CG------A---G -GU-A--A-GG-U--G--C-G--A-GU-G-CGA--CU-GGAG-C---------------- ---------GA-UGA--------------------------G-C--GA-AGG--GAA--G CA-G----GU-GUAGU-CAUG---GCGA-CGGGAAAUA-C-UGUC---U--A-AGG-UU- -A---------------------------------------------------------- -G--GU-U-GCA--AG-A-GACCGUACCGCAAACCGACACAGGUAGGUA-GGA-UGAGUA -A-UCUAAGG-CG-CU-CGAG-AGAACUCG-CGUCAAGGAACUCGGCAAAA-UACACACG UAACCUCGGG-AGAAGUGUGAC-CC-UU--G-C--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UU-U-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GGUGAGG-GUGGCAGAAAGCAGGUCCAGGCGA-----CUGUUUAU CAAAAACAUAGCCAUCUGC-AAAUCA--GU---A-A------------UGAGAC-GU-AU AGGUGGUG-ACACCUGCCCGGUGC-U-GGAAGGUUAAGAGGAGAGGUU-CGUG----GUA A-----CACA-ACGCUUUGAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAUGGUGUAACG ACUC--UGGAC--ACUGUCUCGA-CG-CGA-GACUCGGUGAAAUUUAUGU-ACCGGUAAA GAAGCCGGUUACCCAUAGUUAGACGGAAAGA-CCCCGUGAACC-UUCACCGUAGCUUACU AUUGGAACUUGGUUUACCAUGUGUAGUAU-AGGUGGGAG-AC-AG-A-GAA--GCU--UG GCC--------------------------------------------------------- ----------------------------------GUCA--GGUUA--GGCGGAGU--CA- ACAG-UGAAAUA-CCACCCUUGGUAC-GUCAGGUUUCUAA-CCU-U--UG-----G--CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGGAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-CAA-AGGGA -CCG-UGGUAGGUGGGCGGUUUGACUGGGGCGGU-CGCCUCCUA-AAAGGUAAC-GGAGG UGCGCGAAGGUCUCCUCACACCGGUUGGAAAUCGGUGCGC-GAGUGU-AAAGGCACAA-G GAGGCUUAACUG-CGAGACCG-A----CAGGUCGAGCAGAUACGAAAGUAGGUCUU-AGU G-AUCUGGCG-------------------------G---------UAGCG--UGU-GGA- -----------------------------AGCGCCGUCACUUAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUUUUCCCCAAGAGUUCACAUCGACGGGAAAGUUUGGCACCUC GAUGUCGGCUCAUCGCAUCCUGGGGCUGAAGCAGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGCGGUACGUGAGCUGGGUUCAGAACGUCGCGAGACAGUUCGGUCCCUAUCUGCUA --UGG--G-CGU------------------------------------------------ -----UGGAUAU-GUGAGAGGAG--CUGCUUUUAGUACGAGAGGACCGAAGUGGACGAAC CUC-UGGUGUA-CCAGU-UAUCCUGCCAAGGGU-AC-GUGCUGGGUAGCUA-U-GUUCGG AAG-GGAUAACCGCUGAAGGCAUC--U-AAGUGGGAAGCC------CGC-CUCAAGA--- --UUACAUA---------------------------UC--CCU--------GA-A--G-- G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUGA----------------------------- --------C-CUUC-CUGA---AGACU---CCUU--G-CACACUACAA-GG-UCGAUAGG CUGGA-GGUCUACG-UAC-C-------------------------GUAA----------- --GGUAU--U--AAGCC-----GACC----A-GUACUAAUAAGUCGUGA---GG--CUUG -ACCAU-- >Tropheryma_whipplei --AUUCAAGCUA-C-UUUAAGAGCAAAU-GGUGGAUG-CCU-UGGUA-UCU-G--GAGCC GAAGAAGGACGUAGC-AAUCUGCGAUAAGCCUCGGGAAGCUGAUAAGCG-AGCUUU-GAU CCGAGGAUUUCCGAAUGGGGAAACCUGGUGGGGCGC-----------------AGCA--- ---------------AU----------GCG------------------------------ ---------------------------------ACCCUGUCA-------------CU-CC CGCCU--------------------------GAAUAUAU-A------------------- ---------------GGGCGGGCAGAGGGA-ACGUGGGGAAGUGAAACAUCUCAGUACCC --ACAGGAAGAGAAAGCAA-UAGCGAUUCCGUUAGU-AGU-GGCGAGCGAAACCGG-AAC AGGCCAAA-CCGAUUGAGUGUUA-UAGCCG-GCAGGCG------UUUCUUGAUCGGGG-- -------------------------UAGUGGGAUCCUCUAUGUGGU--UCUGCCGAACC- --ACACGC--GUAGUG--CA--------G---GGGUAUAGG------UG--AAUG--AUU UU-GA-------ACAGU------C-AACC-GAAGAGGGUGAUAGUCCCGUAAUCGAAAUG -C-CCC--G---------GUG----CCGCGAGAGGAUAUCCCAAGUAGCACGGGCCCCGU GAAAUCCCGUGUGAAUCUGUCAAGACCA--CUUGAUAAGCCUAAAUACUAC-CA-GAUAA CCGAUAGU-GGACG-AGUACCGUGAGGGAAAGGUGAAA-AGUAC-CCCGA-GAGGGGAGU GAAAUAGUACCUGAAUCCAUUUGCUUA-CAA-ACCGU-CGGAGCAGUG----------UG CG---------------------ACUUU-----------UGUCGCU-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGUGACGGCGUGCCUUUUGAAGAAUGAGCCUG CGAGUUAGCG----AUGUGUGGCGA---GAUUAA-CCC--------------GUUG---- ---------GGG-G-U-A-GUCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AAU------------------ ------------------------UAGUCGCAUGUCCUA-GACCCGAAGCGAA-GUGAUC UAUCCAUGGCCAGGCUGAAGCGAGG-GUAAGAC-CUCGUGGAGGGCCGA--ACCC-ACUU -AGGUUGAAAACUGAGGGGAUGAGCUGUGGAUCGGGGUGAAAGGCCAAUCAAACUUCG-U UAUAGCUGGUUCUCUCCGAAAUGCAUUUAGGUGCAGCGUUGCG-U--------------- ------------------------------------------------------------ --------------------GUUU-CU-UGCCGGAGGUAGAGCUACUGGAUGGC--CA-A UG--G-GCC-C-UACAA-G-GUUA-CUGACGUCAGCCAAACUCCGAAUGCCGG-UA--A- GUU--------------------------------------------------------- ------------------------------------------------------------ ---------AG--AG--C-GCAGC-AGU-GAG-GCU--GC-GGGGGAUAAGCUUCGU-AG -CCGAGA-GGGAA----ACA--ACCCAGACCACC-GAUUAAG--GUCCC--UAAGUG--U G-U-GC-U-AAG--UGGUA-----------AAGGAUGUGGAGUUGCACAGACAGCCAGGA GGUUGGCUUAG-AAGCAGCCAC-CCUUGAAAGAGUGCGUAAUAGCUCACUGGUC-----A AGUGAUUCUGCGCCGACAAUGUAACGGGGCUA-A-AGCAC---AUC--------ACC--G AAA-UUGUGGC--AUC---G--A----UA-C----------ACAUAGG-UA--------- ----GGCU---------------------------------------------------- ------------------------------------------------------------ ---------------------------UUCGU---------------------------- ------AGUCCA---GC----C---------GUAU-C-G-A-UG-GG--UAGGA----GA ---G-CGUC-GUGU-GG-------------------CG-A-------------------- ------------------------------------------------------------ --------------------------------------------------------AAGA AGCGG-C--G-AUGU-AA-AUCA-GCCG-U-GGA-CGCUAC-A--CGAGUGAGAAUGC-A GGCAU-GAGUA-GCG-A---AA-GGCGG-G------------------UGAAAAA----- ----------CCCGCCCCCCC-GAA-UAACU-AAGGGUUCCA-GGGCCAGGCUAAUCCGC CCUGGG------------UAAGUCGGGAC-C-UAA----GGCG-A-GGCCGAG--AGGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGAC-AAC-GGG--U UGA----UAUU-CCC----GUACC-G-GC-A--AAGA-A-C----C----G--CCCA-UA UUCC--GCGUA---------------------GUUUCG-UUCA---GCAU---------U UUGCU---GUGC-U--UACG--GUAC---------------CCCUUUUACGGUGUGCGGG AUA---AGU-G--------------------------UUCAG-GUG-UG-AC--GCAG-G AAGGUA--GC--C-AA-GC-C-GGG--CGA---UGGU----UGA---CC-CGG-U-GU-- -A------AGU------GU-G------U------A---A----C---C----------CG G-A------G---GG-UA-G--G-----C--AAA-U-CCG-CCCUC-CA----UCUAA-A -GG-GCCA-GG-C--A--C-G--A-CG-C-GUA--GC-GC-------------------- ---------UU-CG---------------------------------G-CGC--GAA--A UU-G----GU-GAUCC-UAUG---CUGA-CUAGAAA-A-G-CAUC---G--A-CAC-AA- ------------------------------------------------------------ -G--GU-U-CUA--GC-U-GCCCGUACCCCAAACCGACUCAGGUGGUUA-GGU-AGAGAA -U-ACCAAGG-GG-AU-CGAG-AGAAUCGU-GGUUAAGGAACUCGGCAAAA-UGCCUCCG UAACUUCGGG-AGAAGGAGGGC-CU--G--A-GG-CGUGACG-AG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UA-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UCU-C-C----- U-----AGC-G-C--U-GCAGG-GUCACAGAAACCAGUGGGGAGCGA-----CUGUUUAU UAAAAACAUAGGUCUGUGC-CAAGUC--GU---A-A------------GACGAC-GU-AU ACAGACUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAGAGGACGGGUC-AGC-----UUU G------GCG-ACGCUCGGAAUUUAAGCCCCG-G-UAAACGG-CGGUGGUAACUAUAACC AUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCA--ACUGUCUCAA-CC-GCG-AACUCGGCGAAAUUGCACU-ACGAGUGAA GAUGCUCGUUACGCGUAGCAGGACGGAAAGA-CCCCG-AGACC-UUUACUAUAGCUUGGU ACUGGUACUUGGUGCGGUUUGUGUAGGAU-AGGUGGGAG-AC-UG-U-GAA--GCG--GG UGC--------------------------------------------------------- ----------------------------------GCCA--GCACU--CGUGGAGU--CG- UUGU-UGAAAUA-CCACUCUGAUCGC-CCCGGGUGUCUAA-CUUAG--AA--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-AAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-UUC-GAGGA -CAA-UGCCUGGUGGGUAGUUUAACUGGGGCGGU-UGCCUCCCA-AAAGGUAAC-GGAGG CGCCCAAAGGUUCCCUCAGCCUGGUCGGUAAUCAGGUGGC-GAGUGU-AAGUGCACAA-G GGAGCUUGACUG-CGAGACUG-A----CGGGUCGAGCAGGGACGAAAGUCGGGACU-AGU G-AUCCGGCA-------------------------G---------UGGCU--UGU-GGA- -----------------------------AGCGCUGUCGCUCAACGGAUAAAAGGUACCU CGGGGA-UAACAGGUUGGUCCCUCCCAAGAGUCCAUAUCGACGGAGGGGUUCGACACCUC GAUGUCGGCUCGUCGCAUCCUGGGGCUGUAGCAGGUCCCAAGGGUUGGGCUGUUCGCCCA UUAAAGCGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGCUA --CGC--G-CGU------------------------------------------------ -----CGGAAAU-UUGAGAGGAG--CUGACCCUAGUACGAGAGGACCGGGUUGGACGAAC CUC-UGGUGUA-CCAGU-UGUCCUGCCAAGGGC-AC--GGCUGGUUUGCUA-C-GUUCGG AAC-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACC------GGC-CUCAAGA--- --UGAGAUU---------------------------UC--CA---------UG-C--C-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUU----------------------------- --------G-GGCG---AG---AGGCU---CCCA--G-UAGAACACUG-GG-UUGAUAGG CUCGA-UGUGUACG-CAG-GGA-----------------------CUAAA---------G -ACCUGU--U--UAGCU-----UACG----A-GUACUAA-UAGGCC-GA---UUG-CUUG -AAACA-- >Vibrio_cholerae --GGUUAAGU---GA-CUAAGCGUACAC-GGUGGAUG-CCU-GGGCA-GUC-A--GAGGC GAUGAAGGACGUACU-AACUUGCGAUAAGCGCAGAUAAGGCAGUAAGAG-CCGUUU-GAG UCUGCGAUUUCCGAAUGGGGAAACCCAACUGCAUA------------------AG----- ---------------C-------------------------------------------- ------------------------------------A-GUUA-------------CUG-U UAACU--------------------------GAAUACAU-A------------------- ---------------GGUUAACAGA-GCAA-ACCGGGGGAACUGAAACAUCUAAGUACCC --CGAGGAGAAGAAAUCAA-CCGAGAUUCCGGUAGU-AGC-GGCGAGCGAACCUGG-AUU AGCCCU-U-AA-------G-------------------------CACUC----------- ------------------------------------------------------------ -------------------G-------G-----UGAAGUAG------GUG-AACA--AGC UG-GA-------AAGCU------U-GGCG-AUACAGGGUGAUAGCCCCGUAACCGACGCU ---UCA-UC---------G-------AGCGUG-AAAUC----GAGUAGGGCGGGACACGU GAUAUCCUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCUGUGAGGGGAGU GAAAUAGAACCUGAAACCGUGUACGUA-CAA-GCAGU-AGGAGCAC-C----------UU C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G----UGG--------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUCAGUGGCAA---GGUUAA-CCG--------------UAU----- ---------AGG-G-G-A-GCCGUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAC--------------- -------------------------------------------U-GGGCG---------- ----------------------------------------CU------------------ ------------------------CAGUCUCUGGAUAUA-GACCCGAAACCGG-GUGAUC UAGCCAUGGGCAGGUUGAAGGUUGA-GUAACAU-CAACUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGACUUGUGGCUAGGGGUGAAAGGCCAAUCAAACUCGG-A GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGGA-C--------------- ------------------------------------------------------------ --------------------GAAU-AC-UACUGGGGGUAGAGC-ACUGUUAAGG--CU-A GG--G-GGU-C-AUCCC-GACUUA-CCAACCCUUUGCAAACUCCGAAUACCAG-UAA-G- U-A--------------------------------------------------------- ------------------------------------------------------------ -------------CUA-U-CCGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGGAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--AAAG-U--A U-U-GC-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCUCAGACAGCUAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUAGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCU--A-AGCAA---UAC--------ACC--G AAG-CUGCGGC--AAU---G--U----CU------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------U-UU----------------------------- --------------------------------AGA-C-A-U-UG-GG--UAGGG----GA ---G-CGUU-CUGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGGUG-A--A-UCGU-AA-GGU--UUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-GAGUA-ACG-A--CAA-AGGGG-G------------------UGAAAAA----- ----------CCUCCU-CGCC-GGA-AGACC-AAGGGUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UGAGUCGACCC-C-UAA----GGUG-A-GGCCGAA--AGGCG ---------------------------U-A-A---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUACU-U-CU-G--ACUA-U-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GGG-GG-AC--GGAG-A AGGCUA--GG--U-GG-GC-C-AGG--CGA---CGG-----UUGU--CC-UGG-U-UC-- -A------AGU------GC-G------U------A---G----G---C-----U----UG A-G------A---GU-UA-G--G-----U--AAA-U-CCG-GCUCU-CU----CUAAG-G -CU-G--A-GA-C--A--C-G--A-CG-U-CGA--GC-UAC------------------- ---------UA-CG--------------------------------GU-AGU--GAA--G UC-A----UU-GAUGC-CAUG---CUUC-CAGGAAA-A-G-CCUC---U--A-AGC-UU- CA---------------------------------------------------------- -G--AU-A-GUC--AG-G-AAUCGUACCCCAAACCGACACAGGUGGUCG-GGU-AGAGAA -U-ACCAAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UGGUACCG UAACUUCGGG-AGAAGGUACGC-UC-UU--G-AU-GGUGAAG-UC-C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UC-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GGA-U-G----- G-----AGC-U-G--A-CGAGA-GUCGCAGAUACCAGGUGGCUGCAA-----CUGUUUAU UAAAAACACAGCACUGUGC-AAAAUC--GC---A-A------------GAUGAC-GU-AU ACGGUGUG-ACGCCUGCCCGGUGC-C-GGAAGGUUAAUUGAUGGGGUU-AGC-----GCA A------GCG-AAGCUCUUGAUCGAAGCCCCG-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAC--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAAAU-CGCUGUGAA GAUGCAGUGUACCCGCGGCUAGACGGAAAGA-CCCCGUGAACC-UUUACUACAGCUUGGC ACUGAACAUUGAACCUACAUGUGUAGGAU-AGGUGGGAG-GC-UA-U-GAA--GAC--GU GAC--------------------------------------------------------- ----------------------------------GCCA--GUUGC--GUUGGAGC--CG- UCCU-UGAAAUA-CCACCCUUGUAUG-UUUGAUGUUCUAA-CUUAG--AC--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-GUU-GAGGA -CAG-UGCCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGCACGAAGGUGGGCUAAUCACGGUUGGACAUCGUGAGGU-UAGUGC-AAUGGCAUAA-G CCCGCUUAACUG-CGAGAAUG-A----CGGUUCGAGCAGGUGCGAAAGCAGGUCAU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGUCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAAGA-UUGAAGGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUU-CGGGU-UGUGUCGCCAGACGC-AU--UGCCCGGUAGCUA-A-GUUCGG AAU-UGAUAAGCGCUGAAAGCAUC--U-AAGCGCGAAGCG------AGC-CCUGAGA--- --UGAGUCU---------------------------UC--CCU--------GA-C--A-- G--U-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- -------AC-UGUC-CUAA---AGGGU---UGUU--C-GAGACUAGAA-CG-UUGAUAGG CAGGG-UGUGUAAG-CGU-U-------------------------GUGA----------- --GGCGU--U--GAGCU-----AACC----U-GUACUAA-UUGCCC-GU--GAGG-CUUA -ACCAU-- >Wolbachia_endosymbiont UAAAUAAAUU-----AUUAAGAGCACUU-GAUGGAUG-CCU-UGGCG-UUA-A--GAGGC GAUGAAGGACGUGGC-AGGCUGCGAUAAGCUGCGGGGAAUUGUCAA-CA-GGUUUU-GAU CCGCAGAUUUCCGAAUGGGGAAACCCAACUAGUUGAGCUA--------------GUUA-- ---------------UU------------------------------------------- -------------------------------------------------------GCA-U GUUA---------------------------G-AUUAA---------------------- ------------------UAUGUAAAGCGA-ACUUGGUGAACUGAAAUAUCUAAGUAGCC --AAAGGAAAAGAAAUCAA-CCGAGAUUCUGUUAGU-AGU-GACGAGCGAAAGCGG-GAA AGGCUAGU-GG-UUU------------------------------AA-G----------- ------------------------------------------------------------ -------------------A-------------AUAAGAAU------UAG-AAUA--CUC UG-GA-------AAGAG------U-AACC-AUAGAAGGUGAUAGUCCUGUAUAGGUAGAA -A-G-U-UU---------U---------UAAA-----UCCUCGAGUAGAGCGGGGCACGU GAAAUCCUGUUUGAACAUGGGGGGACCA--UCCUCCAAGCCUAAAUACUCC-UU-GACGA CCGAUAGU-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCGG-GAGGGGAGU GAAAUAGAAUCUGAAAUCGAGUGCUUA-CAA-ACAGU-UGGAGCUUUA----------UG UU-----------------------UUUG---------CUAUGGGAGCGAU--CUUGUA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCUAAUUUAUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AGUGACAGCGUACCUUUUGCAUAAUGGGUCAG CGAGUUAA-U----CUAUAAAGCAA---GCUUAA-GCC--------------GUUA---- ---------GGU-A-U-A-GGCAUAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-UGGCG---------- ---------------------------------------UUU------------------ ------------------------UAGUUUUAUGGAUUA-GACCCGAAACCAA-GUGAUC UAGUCAUGACCAGAUUGAAGGUGUG-GUAAAAC-ACACUGGAGGAUCGA--ACCA-GUUA -AUGUUGCAACAUUAUUGGAUGAGUUGUGAUUAGGGGUGAAAGGCCAAUCAAACUUGG-A AAUAGCUGGUUCUCCGCGAAAUCUAUUUAGGUAGAGCGUUGUA-U--------------- ------------------------------------------------------------ --------------------GUAU-GU-UGUUGGGGGUAGAGC-ACUUGAUAGA--CU-A GG--G-GGG-C-UCACU-GUCUUA-CCAAAUCUAACUAAACUCCGAAUACCAA-UAA-U- U-GA-------------------------------------------------------- ------------------------------------------------------------ ----------U--UA--U-ACAGC-AGA-CAC-ACU--GC-GGGUGCUAA-GUCCGU-GG -UGGAAA-GGGAA----ACA--GCCCAGAUUACU-AUCUAAG--GUCCC--AAAAUU--A C-A-GC-U-AAG--UGGGG-----------AAGGAAGUAGAAAAACCAUUACAGCUAGGA GGUUGGCUUGG-AAGCAGCUAU-CCUUUAAAGAAAGCGUAACAGCUCACUUGUCUAAAUA AGUUUUUCUGCGCUGAAAAUGUACCGGGGCUA-A-AGCUG---UAU--------ACC--G AAG-AUGUAGG--UAC---U--U----AU-U----------------G-A---------- ----U------------------------------------------------------- ------------------------------------------------------------ ---------------------------UGCA----------------------------- ---------G-----UU--------------AAUA-A-G-U-GC-GG--UAGCG----GA ---G-CGUU-CUGUAAA-------------------UC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGGUA-G--U-UUGU-AA-AAA--CUGC-U-GGA-GAUAUC-A--GAAGUGAGAAUGC-U GACAU-AAGUA-GCG-U--AAA-AGAGU-G------------------UGAAAAA----- ----------CACUCU-CACC-AAA-AAUCU-AAGGGUUCCU-ACGUUAAGUUAAUCUGC GUAGGG------------UUAGUCGGUUC-C-UAA----GGCA-A-GUCCGUAA-AGGAG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UU---GA--U-GGCA-AUC-AGG--U UAA----UAUU-CCU----GAACC-U-CU-U--A-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AG-UGU--G-AC--GGGU-U UUGUA---UU--U-GUAUA-G-GUC-UUAU---UGG-----AUU---GA-CCU-A----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GC-U----UA----AAAA-AA---GCUC-CAGGAAA-U-A-GCAC---U--U-AUAUU-- ------------------------------------------------------------ ----------UA--UG-A-GGCCGUACCGUAAACCGACACUGGUGGAUG-AGU-AGAGUA -U-ACUAAGG-UG--U-UGAA-AGAAUGAU-GUUGAAGGAACUCGGCAAAU-UGUACCUG UAACUUCGGA-AGAAGGGUAAC-CU-GC-----------UUU-UA-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CUA-U-A----- A-----------------GUAG-GUGGCACAAAAUAGGGAGUAGUGA-----CUGUUUAC UAAAAACACAGGACUCUGC-AAACAC--GU---A-A------------GUGGAA-GU-AU AGGGUCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAUAAGAGGGGU----------GUA A------------GCUCUAAAUUGAAGCCCCA-G-UAAACGG-CGGCCGUAACACUGACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCCGCACGAAUGGCGUAACA AU-U--UCUCC--ACUGUCUCCA-AC-AUC-AAUUCAGCGAAAUUGAAUU-CCCCGUGCA GAUGCGGGGUACCCGCGGUUAGACGAAGAGA-CCCCGUGCACC-UUUACUAUAGCUUUAC AUUGGUAUUAAAAAUGUGAUGUGCAGAAU-AGGUGGGAG-AC-UU-U-GAA--GUU--AU GGC--------------------------------------------------------- ----------------------------------GCUA--GCUAU--AAUGGAGU--CA- ACCU-UGAGAUA-CCACCCUUUACAC-UUUUGAUACCUAA-CUAUG--UU--------UC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-A-AAC-UAGGA -CAU-UGUAUGGUGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGAGUAAC-GGAGG CGUGCGAAGGUAAGCUAGAGCUGGUCGGAAAUCAGCUU-GAUAGUAU-AAUGGCAUAA-G CUUGCCUGACUG-CGAGGCUG-A----CAAGCCAAGCAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------A---------UUCUG--UAU-GGA- -----------------------------AGGGUCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUGGUGUUCAAGAGUUCAUAUCGACGACACCGUUUGGCACCUC GAUGUCGACUCAUCACAUCCUGGGGCUGAAGAAGGUCCCAAGGGUUCGGCUGUUCGCCGA UUAAAGUGAUACGUGAGUUGGGUUUAGAACGUCGUGAGACAGUUCGGUUUCUAUCUGCCG --UGG--G-UGA------------------------------------------------ -----AGGAAAU-UUGAGAAGAU--CUGACUCUAGUACGAGAGGACCGAGAUGGAUAUAC CUC-UGGUGUA-CCAGC-UGUUAUGCCAAUAGC-AU--UGCUGGGUAGCUA-U-GUAUAG GUG-GGAUAAUUGCUGAAAGCAUA--U-AAGCAAGAAACC------CUC-UUCAAAA--- ----AGAUU---------------------------UC--CC------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AA-U--UAAGGC---CGUG--G-AAGACUACCA-CG-UUGAUAGG CUAGG-UGUGGAAG-CAU-G-------------------------GUAA----------- --CGUGU--G--GAGCU-----AACU----A-GUACUAA-UAGCCU-GA--UUGA-UUUA -UUUGU-- >Xanthomonas_axonopodis --GGUCAAGC---GA-AUAAGCGCACAC-GGUGGAUG-CCU-AGGCG-GUC-A--GAGGC GAUGAAGGACGUGGU-AGCCUGCGAAAAGUGUCGGGGAGCUGGCAA-CA-AGCUUU-GAU CCGGCAAUAUCCGAAUGGGGAAACCCACUGCU----------------------U----- ---------------CG------------------------------------------- -----------------------------------GC-AGUA------------UCCU-- GCAGU--------------------------GAAUUCAU-A------------------- ---------------GCUGC-UGGAAGCGA-ACCCGGUGAACUGAAAUAUCUAAGUAACC --GGAGGAAAAGAAAUCAA-CCGAGAUUCCCUAAGU-AGU-GACGAGCGAACGGGG-AGC AGCCCU-U-AAGC--------------------------------UGGA----------- ------------------------------------------------------------ -------------------A-------U-----GGCUUUAG------AAA-AACA--AUC UG-GA-------AAGAU------U-GGCC-AUAGAAGGUGAUAGCCCUGUAUUUAAAAGG ---GCC-AC---------U-------CCAGUG-AAGAC----GAGUAGGGCGGGGCACGU GAAACCCUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACCGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGGAGAGGGGAGU GAAAUAGAUCCUGAAACCGUGUGCGUA-CAA-GCAGU-AGGAGC---------------- -----------------------------------------UCG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------CAAG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAC-U----GUUCGUGGCAA---GCUUAA-CCG--------------UAU----- ---------AGG-G-G-A-GGCGAAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AUA--------------- -------------------------------------------A-GGGCG---------- ----------------------------------------CA------------------ ------------------------UAGUCGCGGGCAGUA-GACCCGAAACCGG-GUGAUC UAGUCAUGGCCAGGGUGAAGGUGCC-GUAACAG-GUACUGGAGGCCCGA--ACCC-ACGU -CUGUUGCAAAAGACGGGGAUGAGCUGUGAUUAGGAGUGAAAAGCUAAUCGAACCCGG-A GAUAGCUGGUUCUCCUCGAAAGCUAUUUAGGUAGCGCCUCAUA-U--------------- ------------------------------------------------------------ --------------------GUAU-CC-UCUCGGGGGUAGAGC-ACUGUUAUGG--CU-A GG--G-GGU-C-AUCGC-GACUUA-CCAAACCAUUGCAAACUCCGAAUACCGA-GAC-G- G-A--------------------------------------------------------- ------------------------------------------------------------ ---------C---UG--U-AUGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAAA-GGGAA----ACA--ACCCAGACCCAC-AGCUAAG--GUCCC--AAAUUC--A C-U-GC-U-AAG--UGGAA-----------AACGAUGUGGAAAGGCAUAGACAGCCAGGA GGUUGGCUUAGAA-GCAGCCAC-CCUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGGUCUGCGCGGAAGAUUUAACGGGGCU--A-AGCAG---UGA--------ACC--G AAG-CUUGGGG--UGC---A--U----AA-A---------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CGUG----------------------------- ---------------------U---------UUUA-U-G-C-GC-GG--UAGAG----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCGA AGGUG-G--A-UUGA-GA-AGU--CUGC-U-GGA-GGUAUC-G--GAAGUGCGAAUGC-U GACAU-GAGUA-ACG-A--UAA-UGCGG-G------------------UGAAAAG----- ----------CCCGCA-CGCC-GAA-AGCCC-AAGGUUUCCUUGCGCAACGUUAAUCGAC GCAGGG------------UUAGUCGGUCC-C-UAA----GGCG-A-GGGCGAA--AGCCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AGC-AGG--U UAA----UAUU-CCU----GCACC-U-CG-C--GUGA-G-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------UG-GAG-GG-AC--GGAG-A AGGUUA--GG--U-GU-AC-C-GGG--CGU---UGG-----UUGU--CC-CGG-G-GA-- -A------AGG------CG-G------U------A---G----G---U-----U----UG G-A------U---CU-UU-G--G-----C--AAA-U-CCG-GGA-U-CC----UUUAAGA -CC-G--A-GC-A--C--C-G--A-GA-C--GA--GC-CU-------------------- ---------UU--U---------------------------------U-GGC--GAA--G UC-A----CU-GAUAC-CACG---CUUC-CAGGAAA-A-G-CUCC---U--A-AGC-UU- CA---------------------------------------------------------- -G--CU-C-ACG--A--A-GACCGUACCGUAAACCGACACAGGUGGGUA-GGA-UGAGAA -U-UCUCAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAACA-UGGCACCG UAACUUCGGG-AGAAGGUGCAC-CC-UU--U-UU-GGUGG-C-UC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AU-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GA-GCUA---- U-----AGC-U-G--A-AGAGG-GUCGCAGAAACCAGGCCGCUGCGA-----CUGUUUAU CAAAAACACAGCACUCUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU AGGGUGUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAUUGAUGGGGUC-AGCC----GCA A-----GGCG-AAGCUCUUGAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-A--GCGGC--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAAAU-CGCUGUGAA GAUGCAGCGUUCCCGUGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUUAC ACUGAACGUUGAGUUCGUCUGUGUAGGAU-AGGUGGGAG-GC-UA-U-GAA--ACU--GU GGC--------------------------------------------------------- ----------------------------------GCUA--GCUGC--AGUGGAGC--CA- UCCU-UGAAAUA-CCACCCUGUCGUG-CUUGACGUUCUAA-CCUAG--GU--------CC G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CG-G-AUC-AGGGA -CCG-UGUAUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCUA-AAGAGUAAC-GGAGG AGCACGAAGGUACGCUCAGCGCGGUCGGACAUCGCGCACU-GUGUGC-AAAGGCAUAA-G CGUGCUUGACUG-CAAGAUCG-A----CGGAUCAAGCAGGUACGAAAGUAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--UAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGUAGUCGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCA --UGG--G-CGU------------------------------------------------ -----UGGAAGU-UUGAGAGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAC CUC-UGGUGUU-CCGGU-UGUCACGCCAGUGGC-AU--UGCCGGGUAGCUA-U-GUUCGG AAG-CGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCG------CGC-CUCAAGA--- --UGAGACU---------------------------UC--CC---------GG-G--G-- C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ACAA----------------------------- --------G-CCCC-CUAA---AGGAA---CCAU--G-UAGACUACGU-GG-UUGAUAGG UCAGG-UGUGUAAG-UAC-A-------------------------GCAA----------- --UGUAU--U--GAGCU-----AACU----G-AUACUAA-UGAUCC-GU--GCGG-CUUG -ACCAU-- >Yersinia_pestis --GGUUAAGC---GA-CUAAGCGUACAC-GGUGGAUG-CCU-AGGCA-GUC-A--GAGGC GAUGAAGGGCGUGCU-AAUCUGCGAAAAGCGUCGGUAAGCUGAUAUGAA-GCGUUA-UAA CCGACGAUACCCGAAUGGGGAAACCCAGUGCAAUA------------------CG----- ---------------UU------------------------------------------- -----------------------------------GC-ACUA-------------UCG-U UAGAU--------------------------GAAUACAU-A------------------- ---------------GUCUA-ACGAGGCGA-ACCGGGGGAACUGAAACAUCUAAGUACCC --CGAGGAAAAGAAAUCAA-CCGAGAUUCCCCCAGU-AGC-GGCGAGCGAACGGGG-AGG AGCCCA-G-AGUCUGA-AU-------------------------CAGUU----------- ------------------------------------------------------------ -------------------U-------G-----UGUGUUAG------UGG-AAGC--GUC UG-GA-------AAGUC------G-CACG-GUACAGGGUGAUAGUCCCGUACACCAAAAU ---GCA-CA---------G-------GCUGUG-AACUC-GAUGAGUAGGGCGGGACACGU GACAUCCUGUCUGAAUAUGGGGGGACCA--UCCUCCAAGGCUAAAUACUCC-UG-ACUGA CCGAUAGU-GAACC-AGUACCGUGAGGGAAAGGCGAAA-AGAAC-CCCGGCGAGGGGAGU GAAAUAGAACCUGAAACCGUGUACGUA-CAA-GCAGU-GGGAGCAC-C----------UU C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G----UGG--------UGUGACUGCGUACCUUUUGUAUAAUGGGUCAG CGACUUAU-A----UUUUGUAGCAA---GGUUAA-CCG--------------AAU----- ---------AGG-G-G-A-GCCGUAGGGAAA-CCG------------------------- ---------------------------------------------------------AGU CUU---------------------------------------AAC--------------- -------------------------------------------U-GGGCG---------- ----------------------------------------UC------------------ ------------------------UAGUUGCAAGGUAUA-GACCCGAAACCCG-GUGAUC UAGCCAUGGGCAGGUUGAAGGUUGG-GUAACAC-UAACUGGAGGACCGA--ACCG-ACUA -AUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGG-A GAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUG-A--------------- ------------------------------------------------------------ --------------------ACUC-AU-CUUCGGGGGUAGAGC-ACUGUUUCGG--CU-A GG--G-GGC-C-AUCCC-GGCUUA-CCAAACCGAUGCAAACUCCGAAUACCGA-AGA-A- U-G--------------------------------------------------------- ------------------------------------------------------------ ---------UU--AU--C-ACGGG-AGA-CAC-ACG--GC-GGGUGCUAACGUCCGU-CG -UGAAGA-GGGAA----ACA--ACCCAGACCGCC-AGCUAAG--GUCCC--AAAGUC--A U-G-GU-U-AAG--UGGGA-----------AACGAUGUGGGAAGGCACAGACAGCCAGGA UGUUGGCUUAG-AAGCAGCCAU-CAUUUAAAGAAAGCGUAAUAGCUCACUGGUC-----G AGUCGGCCUGCGCGGAAGAUGUAACGGGGCU--A-AACCA---UGC--------ACC--G AAG-CUGCGGC--AGC---G--A----CA-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAG----------------------------- -------------------------------GUGU-U-G-U-UG-GG--UAGGG----GA ---G-CGUU-CUGUAAG-------------------CC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGGUG-A--C-CUGU-GA-GGG--UUGC-U-GGA-GGUAUC-A--GAAGUGCGAAUGC-U GACAU-AAGUA-ACG-A--UAA-UGCGG-G------------------UGAAAAA----- ----------CCCGCA-CGCC-GGA-AGACC-AAGGGUUCCU-GUCCAACGUUAAUCGGG GCAGGG------------UGAGUCGACCC-C-UAA----GGCG-A-GGCUGAA--AAGCG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-U-GG-U--GUUA-C-U------------------- -----------------------------------------------------------G CGA--------------------------------------------------------- ----------------------------------------AG-GGG-GG-AC--GGAG-A AGGCUA--GG--C-UG-GC-C-GGG--CGA---CGG-----UUGU--CC-CGG-U-UU-- -A------AGC------GU-G------U------A---G----G---G-----G----GA G-U------G---AC-CA-G--G-----U--AAA-U-CCG-GUUGC-UU----AUCAACC -CU-G--A-GG-C--G--U-G--A-UG-A-CGA--UG-CAC------------------- ---------CA-CG--------------------------------GU-GCA--GAA--G CA-G----UU-GAUGC-CAUG---CUUC-CAGGAAA-A-G-CCUC---U--A-AGC-AU- CA---------------------------------------------------------- -G--GU-A-ACA--UU-A-AAUCGUACCCCAAACCGACACAGGUGGUCA-GGU-AGAGAA -U-ACUCAGG-CG-CU-UGAG-AGAACUCG-GGUGAAGGAACUAGGCAAAA-UGGUGCCG UAACUUCGGG-AGAAGGCACGC-UG-GC-GU-UA-GGUGAAA-GG-A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UA-GC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------UCC-U-G----- G-----AGC-U-G--A-AGCCA-GUCGCAGAUACCAGCUGGCUGCAA-----CUGUUUAA UAAAAACACAGCACUGUGC-AAACAC--GA---A-A------------GUGGAC-GU-AU ACGGUGUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAUUGAUGGGGUC-AGCC----GCA A-----GGGG-AAGCUCUUGAUCGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAAUG AU-G--GCCAG--GCUGUCUCCA-CC-CGA-GACUCAGUGAAAUUGAACU-CGCUGUGAA GAUGCAGUGUACCCGCGGCAAGACGGAAAGA-CCCCGUGAACC-UUUACUAUAGCUUGAC ACUGAACAUUGAGCCUUGAUGUGUAGGAU-AGGUGGGAG-GC-CU-U-GAA--GUG--UG GAC--------------------------------------------------------- ----------------------------------GCCA--GUCUG--CAUGGAGC--CA- ACCU-UGAAAUA-CCACCCUUUAAUG-UUUGAUGUUCUAA-CUCGG--CC--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GAUC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-GGU-GAGGA -CAG-UGUCUGGUGGGUAGUUUGACUGGGGCGGU-CUCCUCCCA-AAGAGUAAC-GGAGG AGCACGAAGGUUAGCUAAUCACGGUCGGACAUCGUGAGGU-UAGUGC-AAAGGCAUAA-G CUAGCUUGACUG-CGAGAGUG-A----CGGCUCGAGCAGGUACGAAAGUAGGUCUU-AGU G-AUCCGGUG-------------------------G---------UUCUG--AAU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACUC CGGGGA-UAACAGGCUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGAAGUAGGUCCCAAGGGUAUGGCUGUUCGCCAU UUAAAGUGGUACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----UGGAAGA-UUGAGAGGGG--CUGCUCCUAGUACGAGAGGACCGGAGUGGACGAAU CAC-UGGUGUU-CGGGU-UGUCAUGCCAAUGGC-AU--UGCCCGGUAGCUA-A-AUUCGG AAG-AGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAACU------UGC-CUCGAGA--- --UGAGUCU---------------------------UC--CCU--------GG-G--A-- C--U-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAA----------------------------- -------AG-UCCC-CUGA---AGGAA---CGUU--A-AAGACUAUGA-CG-UUGAUAGG CUGGG-UGUGUAAG-UGC-A-------------------------GCGA----------- --UGUAU--U--GAGCU-----AACC----A-GUACUAA-UGAUCC-GU--GAGG-CUUA -ACCUU-- >Zymomonas_mobilis --------------AGGUAAGAGCAUUU-GGUGGAUG-CCU-AGGCA-UAC-A--CAGGC GAUGAAGGACGUGGC-ACGCUGCGAUAAGCUACGGCGAGAUGUGAG-CA-AUCUUU-GAC CCGUAGAUUUCCGAAUGGGGAAACCCAUCCUCACCAUUU----------------AAU-- -------UUCGAU--AUUG--U-----UC------------------------------- ----UGCAGU-----AUC-----------------GGAGUUAGGUGGGAAGGAUAUUACC AAAGU--------------------------GAAUACAU-A------------------- ---------------GCUUUGGUGAAGCGA-ACCCGGCGAACUGAAACAUCUAAGUACCC --GGAGGAAAAGACAUCAA-CCGAGAUUCCGUUAGU-AGU-GGCGAGCGAACGCGG-AGU AGGCCAGU-AC-CUU------------------------------UG-A----------- ------------------------------------------------------------ -------------------U-------------UGCGUUAG------CAG-AAGU--CUU UG-GA-------AAGAG------A-CACC-AUAGUGGGUGACAGUCCCGUAUGUUAAAAC -A-A-U-AU---------U---------GAAG-----GUCUUGAGUAGGGCGGGGCACGU GAAACCUUGUCUGAACAUGGGGGGACCA--CCCUCCAAGCCUAAAUACUCG-UG-UAUGA CCGAUAGU-GAACA-AGUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCGAUUAGGGGAGU GAAACAGUUCCUGAAACCGAAUGCUUA-CAA-GCAGU-AGGAGGGUCU-----------U U----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CCUGACUGCGUACCUCUUGCAUAAUGGGUCUG UGACUUAA-U----GUAUCAAGCAA---GCUUAA-GCC--------------GAUA---- ---------GGU-G-U-A-GGCGCAGCGAAA-GCG------------------------- ---------------------------------------------------------AGU CUG---------------------------------------AAU--------------- -------------------------------------------A-GGGCG---------- ---------------------------------------AUU------------------ ------------------------UAGUUUGAUGCAUUA-GACCCGAAACCCG-GCGAUC UAGGCAUGGUCAGGAUGAAGGUAAG-GUAACAC-UUACUGGAGGUCCGA--ACCG-AUUA -ACGUUGAAAAGUUAUCGGAUGAACUGUGUUUAGGGGUGAAAGGCCAAUCAAGCCGGG-A AAUAGCUGGUUCUCCGCGAAAACUAUUGAGGUAGUGCCUCAUG-U--------------- ------------------------------------------------------------ --------------------GAUG-AC-CGUUGGGGGUAGAGC-ACUGGAUGGA--UG-C GG--G-GGU-U--UCGC-GACCUA-CCAAAUCUAACCAAACUCCGAAUACCAA-CGA-G- U-U--------------------------------------------------------- ------------------------------------------------------------ ----------U--AA--C-AUGGG-AGA-CAG-ACG--GC-GGGUGCUAAGGUCCGU-CG -UCGAGA-GGGAA----ACA--GCCCUGACCUAC-AGCUAAG--GUCCC--CAAGUC--A U-G-UC-U-AAG--UGGGA-----------AAGCUUGUGAAGACCCCAAAACAACCAGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAAAGCGUAACAGCUCACUGGUCUAAAUA AGGGUCUUUGCGGCGAAGAUGUAACGGGGCUC-A-AGACA---UGC--------ACC--G AAG-CUUAGGA--UUG---U--U----AC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUUA----------------------------- --------------------------------GUA-A-C-A-GU-GG--UAGCG----GA ---G-CGUU-CCGUAAG-------------------CC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGA AGCAG-U--C-UGGU-AA-UGG--ACUG-U-GGA-GGUAUC-G--GAAGUGCGAAUGC-A GACAU-GAGUA-GCG-A--UAA-AUAGG-G------------------UGAGAUG----- ----------CCCUAU-CGCC-GAA-AGUCC-AAGGGUUCCU-GCGCAAGGCUAAUCCGC GCAGGG------------UGAGUCGGCCC-C-UAA----GACG-A-GCCCGAA--GGGGG ---------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA--U-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-U-GG-A--GA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GA-UGU--G-AC--GGAU-C GUGUAA--AU--U-GU-AU-G-UCC-UUAU---CGG-----AUU---GG-ACA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GC-U----CA----UAAG-CG---GUUC-CAGGAAA-U-A-GCCU---C--U-------- ------------------------------------------------------------ ---------CCA--UAUA-GACCGUACCCUAAACCGACACAGGUGGACA-GGU-AGAGUA -U-ACCAAGG-CG-CU-UGAG-AGAAGGGU-GUUGAAGGAACUCGGCAAAU-UGCCUCCG UACCUUCGGA-AGAAGGAGGCC-CU-UA-----------UUA-UA-G------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------CUA-U-U----- C-----------------UAAG-GGGGCACAGGCCAGGGGGUAGCGA-----CUGUUUAG CAAAAACACAGGGCUCUGC-AAAGUC--GGCUUCAA------------GACGAC-GU-AU AGGGCCUG-ACGCCUGCCCGGUGC-U-GGAAGGUUAAGUGGAGGAGU----------GCA A------------GCUCUGAAAUGAAGCCCCA-G-UAAACGG-CGGCCGUAACUAUAACG GUCCUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCACGAAUGGCGUAACG AC-U--UCCCC--ACUGUCUCCA-AC-ACC-UGCUCAGCGAAAUUGAAUU-CUCCGUGAA GAUGCGGAGUACCCGCGGUUAGACGGAAAGA-CCCCGUGCACC-UUUACUGCAGCUUCAG AGUGGCAUUAGGAAAGAACUGUGUAGCAU-AGGUGGGAG-GC-UU-U-GAA--ACU--UG AGC--------------------------------------------------------- ----------------------------------GCCA--GCUUG--AGUGGAGC--CA- UAGG-UGAAAUA-CCACCCUGUUGUU-UUCUGAUGUCUAA-CCUAG--AA--------CC A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UGAAAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------UG-G-UUC-AGGGA -CCC-UCUGUGGCGGGUAGUUUGACUGGGGCGGU-CGCCUCCUA-AAGAGUAAC-GGAGG CGCGCGAUGGUUGGCUCAGGCCGGUUGGAAACCGGCUGCAAGAGUGC-AAUGGCAUAA-G CCAGCCUGACUG-UGAGACUG-A----CAAGUCGAACAGAGACGAAAGUCGGUCAU-AGU G-AUCCGGUG-------------------------G---------UCCCU--CGU-GGA- -----------------------------AGGGCCAUCGCUCAACGGAUAAAAGGUACGC CGGGGA-UAACAGGCUGAUAACCCCCAAGAGCUCAUAUCGACGGGGUUGUUUGGCACCUC GAUGUCGGCUCAUCACAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUUGGCUGUUCGCCAA UUAAAGUGGUACGUGAGCUGGGUUCAGAACGUCGCGAGACAGUUUGGUCCCUAUCUGCCG --UGG--G-CGU------------------------------------------------ -----C-GAUAU-UUGAGAGGAG--UUGCCCUUAGUACGAAAGGACCGGGGUGAACAUGC CUC-UGGUGGA-CCUGU-CGUGGCGCCAGCCGC-GC--AGCAGGGUAGCUA-U-GCAUGG ACG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------UCC-CUCAAGA--- --UAAGAUA---------------------------UC---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------U--CAGAGC---CGUC--G-AAGACUACGA-CG-UUGAUAGG CCAGA-UGUGGAAG-UGU-G-------------------------GUAA----------- --CACAU--G--UAGCU-----AACU----G-GUCCUAA-UUGCUC-UA--UUCA-CGCU --UUUG-- >Aeropyrum_pernix ------------GGCACCUAUGCCGCCC-GGGGGAUG-GCU-CGGCU-CGG-G--CGC-C GAGGAAGGGCGUGGC-AAGCUGCGAUAAGCCCGGGGUAGGCGCAGG-CA-GCCGUC-GAA CCCGGGAUCCCCGAAUGGGACU-UCCC--------------------------------- -------------GCUG------------------------------------------- ----------------------------------------CG-------------GGC-G AAGAGCCCGC-----AGC-------------GCCC------CCGUUUGGG---------- -----------------------GGCGGGA-ACCCCCCGAAAGGAAGCAUCUGAGUAGAG --GGAGGAGAAGAAACCAACA-GGGAUCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAG AGCCCAAA-CCAAUCCCCCACGG--GAG---GACCGUGGG--GGGAUGAGGGGUUG---- ----------------------------CGGCCCUGCGGCUGG--------GGCU----- ------UCGAGCCCCGGCGGGC--CGAC----CCACGGUAG------CCG-AAGUG-GGC UG-GA-------AUGCC------C-CGCC-GUAGAGGGUGAUAGCCCCGUAGGCGAAACC --GUGG-GG---------GCC-----CGUGCCGC--AGGGCAGAGUACCACGGCUU---G GUAUUGCCGUGGGAAGCUGGGAGGAACC-GACUUCCAAGGCUAAAUACGU--CC-CGAGA CCGAUAGC-GAACUAAGUACCGUGAGGGAAAGCUGAAA-AGAAC-CCCGGGAGG-GGGGU GAAA-AGAGCCUGAAACCGGGCGGCGA-CAU-ACGGU-GCGACCCGAAAGGGGUGAAAC- CCCCGAA-----------------------------------GGAAACCCG--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACCGGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG-GAUGG---ACCGGGGUCGCACCGUCCGUCUUGAAACACGGGCCGG GGAGUUCA-C----GGCCGUGGCGA---GCUUAA-GGG--G----------GUCAA---- --------CCCC-G-U-A-GGCGCAGGGAAA-CCGAC--------AGGCCCGC----AGC CGGGG---GCGA--CCCCGGC-G----AGGGG-CGG---------------------GGU CC----------------------------------------UAAUA------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACGGCCGUGA-GACCAGAAACCGG-GCGAUC UAGGCGGGGGCAGGGCGAAGCCGGG-GGAAACC-CCGGUGGAGGCCCGCA-AGGG--UGC UGACGUGCAAAUCGCUCCCCUGACCCCCGUCUAGGGGUGAAAGGCCAAUCUAGCCCGGAA GAUAGCUGGUUCCCGCCGAAGUGGCUCGCAGGCCAGCCCCGCC-G--------------- ------------------------------------------------------------ -------------------GAGGCCGG-GCCGUGGGGUAGAGCUACUGAUUGGG--CG-U GCAGG-GGG-C-GUAAA-GCCCCC-GGCG-CCCAGUCAAACUCCGAACCUGCG-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-GCGGG-AGU-GGGGUUC--CC-CGGGG-UAAGCCCGGG-GG -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--UAAGUG--C C-G-GC-U-AAG--UGCCAA-GCC---A--AAGGGCGUCCCCCGCCUAAGACAGCGGGGA GGUGGGCCUAA-CAGCAGCCAU-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGGCGGGGGGCCCCGAAGAUUGGUCGGGGCUU-A-AGCCG---GCC--------GCC--G AGA-CCCCGGG--C-C---G--C----GG-C---------------UC-C---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAU------------------------------ ---------------GG----A---------GCCG-C-GU--GC-GG--UAGGC----GG ---G-CGUC-GGGG-UG-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGCCG-G--G-CCGC-GA-GGU--CCGG-U-GGA-GCCGCC-C--CGAGCGCGGAUCC-C GGCGG-UAGUA-ACAGC-G-AA-GCGGG-G------------------UGAGAAU----- ----------CCCCGC-CGCCGGAA-AGGGC-AAGGGUUCCC-CGGCAAUGGUCGUCAGC CGGGGG------------UCAGCCGG-UC-C-UAA----CCGG-G-ACCGUAA-CACGGA U--------------------------C-C-C---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AG-GGGA-AAC-GGG--U UAA----CAUU-CCC----GUGCC-G-CG-G--GGGU-A-C--GCUUC--G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AGGCCCCAC-CCC-CG-AC--GCCU-C GGGGUA--GG--C-GGACC-G-GGG--GCCCCCUUAG-GGGGGCG--AC-CCGG--CU-- -A------ACC------UGCC------G------A--------A---G-----G--CCGG G-G------A---GU-G--C--C-----G--UAA-C-GGC-GAGAA-CC--GG----C-C -G--A--AGGG-G--G--G-A--A-U--G---GC-CC-GCC------------------- ----------U-AU--------------------------------GG-CGG---UU--- CC-G----CC-GACCC-C-UG-G-A-CC-CUUGAAA-A-G-GGGG---U--G-GGG-AA- ------------------------------------------------------------ -G--GAUC-CCC--CG-C-GCCCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAGCA -G-CCCAAGG-CGUCU-GGGGGCUAACCCG-GGCCAGGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-GC--G-GU-CCUGGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UCGAA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------C-C----- C-----UGG-G-A--C-CGCAG-GUCGCAGUGCCUAGGGGGGCCUGA-----CUGUUUAA CAAAAACAUAGCUCCCCGC-UAGCCC--GA---A-A------------GGGUGU-GU-AC GGGGGGUG-AGCCCUGGCCACUGG-C-GGUCCGUGAAA-CCGGGG------------UAC A--------------ACCCGG-CGAAGCGCCG-C-UGAAGGC-CGGGAGUAACCCUGACU CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGCGCAUGAACGGGUCAACG AG-G--UCCCC--ACUGUCCUGG-CC-CGG-GGCCCCGUGAACCCCCUGA-GCCGGUGCA CAGUCCGGCAUCCCCCCGCAGGGAGAGAAGA-CCCCGUGGAGC-UUUACCGCAGCCCGGC GUUGGCCCCCGGGCGGGGGUGCGUAGCGU-AGGUGGGAG-CC-GA-U-GAG--CCA--CC CUC--------------------------------------------------------- ----------------------------------UCCG--GGGGG--UGGGGAGG--CG- UCCA-UGAAACA-CCACCCACCCCCG-CCCGGGGGCCUAA-CCC-C--GC--------CC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------C-GGGU- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------G-G-GCG-GGGGA -CAG-CGUCGGGUGGGCGGUUUGGCUGGGGCGGCACGCCCGCGA-AGGGGUAAC-ACGGG CGCCCAAAGGUCGGCUCAGGCGGGUCAGAACUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACCG-GACCCCUGAAA--GCAAGGGGUCCGGCCGGGAAACCGUGGCCU-AGC G-CACGCUCG------------------------UG---------C-CCCC--UC-GGU- ----------------------------GGGGGCCGGGCACGA-CAG--AAAAGUUACCC CGGGGA-UAACAGAGUCGUCGCGGGCGAGAGCCCCCAUCGACCCCGCGGUUUGCUACCUC GAUGUCGGCUCUUCCCAUCCUGGGGGUGCAGCAGCCCCCAAGGGUGGGGCUGCCCGCCCA UUAAAGGGGAACGUGAGCUGGGUUCAGACCGUCGUGAGACAGGUCGGUCUCUACCCGCGG --GGG--G-UGU------------------------------------------------ -----GGGCCGC-CUGAGGGGAAG-GUGCCCUUAGUACGAGAGGAACGGGGCGCCGCGGC CUC-UGGUGUA-CCGGU-UGUCC-UGGU-GGGC-AA--CGCCGGGCAGCUA-A-GCCGUA -GG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CUC-CCCGAAA--- --AGAGGCG---------------------------GC--CGU--------UG-G--G-- C--GCC-G-GC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUAGU---------------------------- --GCCGGCG-UCCA--C-G---AGGGC---UCCC--G-UAGAAGACGG-GG-UUGAUGGG GCGGG-GGUGUGAG-CCC-CGAGAG----G---------------GCUU--A--GCCCUC GAGGGGU--G--UAGCC-----CGCC----G-CUCCCAA-UCGCCC-GA--G--G-CCG- -------- >Archaeoglobus_fulgidus -----------CGGCGAAUAUCCCGGCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GACGAAGGGCGUGCC-AAGCUGCGAAAAGCCCGGGGGAGGCGCAAG-GA-GCCUUA-GAA CCCGGGAUUCCCGAAUGGGAUA-UCCU--------------------------------- -------------GUCC------------------------------------------- ----------------------------------------CU-------------UCG-G GGACGCUCCC-------------------------------UU----------------- -----------------ACG-GGAGCGGGA-ACGCGGGGAAAGGAAACAUCUGUGUACCC --GCAGGAAAAGAAAGCAAAC-GCGAUGCCGUGAGU-AGG-GGCGACCGAAAGCGG-CAC AGCCCAAA-CCGAACAUCCGGGG--GU----AACUCCGGA--UGGAUGUGGUGUUG---- ----------------------------UAGGACCCUGCCU------------------- ------AA--UGC-----CG-------U----GGAACGAAG------CCG-AAGUG-GUC UG-GA-------ACGGC------C-CGCC-GUAGAGGGUGAUAGCCCCGUAGGCGUAAGU -U-CCA-CG---------GUU----ACAAGGCGGGGUAUCCUGAGUACCGUGGGUU---G GAAUUCUCGCGGGAAGCUGGGGGUCAUC-AACCCCCAAGGCUAAAUACGU--CC-CGAGU CCGAUAGC-GCAAUA-GUAGGGUGACCGAAAGCUGAAA-AGAAC-CCCGAGAAGGGGAGU GAAA-AGAGCCUGAAAUCGGCCGGGGA-UAG-UGAGC-AGUGGCUCGAAAGGU-AAUCC- CGGCAAA-----------------------------------GGAAAGUGC--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GAGAGGCGCGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGCCGGGACAU---GCCGGAGUCACUGCGUACGUUCUGAAGAACGGGCCAG GGAGUGUA-C----GGCAGGGGCGA---GGCUAA-GGA--G-U---------GAA----- -------ACUCC-G-A-A-GCCGGAGGGAA-ACCGAC---------AGCCCGC----AGC --------UUAU-------GC-G----AGGGG-CGG---------------------GGU G-----------------------------------------UGCU-------------- ----------------------------------------------CGCC---------- ----------------------------------------UG------------------ ------------------------UAGUCCCUGCCGUAC-GACCCGAAGCCGG-GCGAUC UAGGCGGGGGCAGGGUGAAGCGGUG-CGAAAGC-GCCGUGGAGGCCCGC--AGGG-GUGU UGAUGUGCAAAUCGCUCCUCUGACCCCCGUCUAGGGGUGAAAGUCCAAUCGAGCCCGG-G GAUAGCUGGUUCCCCCCGAGACAUACCGCAGUAUGACCCGUCC-G--------------- ------------------------------------------------------------ -------------------GAGGU-UG-GCGGUGGGGUAGAGC-ACUGAUAGGA-GGA-U CC-GG-GGG-G-UGAC--ACCCUC-GCCC-UCCUGUCAAACUCCGAAUCCACC-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-GGCGG-AGU-CAG-GGG--CA-GGGGG-UAAGCUCCUG-UU -CCGAGA-GGGAG----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--UAAGUG--C C-G-GC-U-AAG--UGUAAA-CGAU--A--AAGGAGGUCCCGGGUCGAAGACAGCGGGGA GGUAGGCUUAG-AAGCAGCCAC-CCUUUAAAGAGUGCGUAACAGCUCACCCGCC-----G AGACUCGGGGCGCCGAAAAUG-GACGGGGCUC-A-AGCCG---GCC--------GCC--G AUA-CCCCGGG--G-C---U--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- ---------------------------------GG-A-GAU-CC-GG--UAGGG----GG ---G-CGUG-CCGA-UG-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGCCU-GA-G-GCGU-AA-GCU--CGGG-U-GGA-GCCGUC-G--GUAACGAAUAUCC-U GGCGG-UAGUA-GCAGC-A-UA-GUCGG-G------------------UGAGAAU----- ----------CCCGAC-CGCC-GGA-AGGGC-AAGGGUUCCA-CGGCAAUGUUCGUCAGC CGUGGG------------UGAGUCGG-UC-C-UAA----GGUG-G-CCCGUAA-CUCGGC G--------------------------C-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GAAAA-GGGA-AGC-CGG--U UAA----UAUU-CCG----GCACC-G-CU-G--C-------------------------- ---------------------------------------------------------CCG CUGCC------------------------------------------------------- ---------------------------------UUUAUGGCA-CCC--G-AC--GCCU-C GGGAUA--GG--C-CGGGC-G-GGA--G-----CUGCC-----A---GC-CCGU--CC-- -A------AGC------GU-C------G------A--------A---G-----C--CCCC G-G------A---GA-U--C--C-----G--UAA-U-GGA-GAGAA-GG--GG----G-U -G--A--AGGC-G--U--G----A-UG-G-C----------------------------- ---------GU-AA----------------------------------------GC---- CG-G----CC-GACUC-C-UG-G-GGCC-CGUGAAA-A-G-GGGG---G--C-A------ ------------------------------------------------------------ ----------GU--UG---GACCGUACCGAGAACCGACACAGGUGCCC-UGGG-UGAGUA -G-CCUAAGG-CGUGG-CGGAA-CAUUCCG-GCCGAGGGAAUUCGGCAAGU-UGGCCCCG UAUCUUUGGU-AGAAGGGGUGC-CU-GC--G-GU-U------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U AG-CA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------G-A--C-CGCAG-GUCGCAGUGACUAGGGGGGAGCGA-----CUGUUUAC UAAAAACACAGGGGGCUGC-AAUCCG--GC---A-A------------CGGUUU-GU-AC AGCCCCUG-AGUCCUGCCCAGUGC-G-GGUACCUGAAA-CCAGGG------------UAC A--------------ACCGGG-CGAAGGGCCC-G-UAAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAAUACCUUGCCGCU-UAAUUGGCGGCUUGCAUGAACGGAUUAACG AC-U--CCCCC--ACUGUCCCCG-GC-CGG-AAGCCGGCGAACCCGACAU-CCCAGUGAA GAGUCUGGGGACCCCCGUUGGGAAGCGAAGA-CCCUGUGGAGC-UUUACUGCAGCCUGCC GUUGCUCCACAGCUGGGGGUGCGCAGGGU-AGGCGGGAG-GCUU--C-GAA--GCC--CC GUC--------------------------------------------------------- ----------------------------------UCCG--GGCGG--GGUGGAGC--CG- UCGA-UGAGACA-CCGCCCACCUCCA-GCUGUGGAGCUAA-CUC-C--C----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GCU--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GG-GAGGA -CAU-CGGUAGGUGGGCAGUUUGGGUGGGGCGCCACUCCCCCGA-AAAGGUAUC-GGGGG AGCCCAAAGGUCGGCUCAGGCGGGUCAGAAAUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACGU-GAACCCGCAAAA--UAAGGGUUCACGAGCCGAAAGGCGGGCCU-AGC G-AACCACCC------------------------UG---------G-CCUU--UU-GGU- ----------------------------GAGGCCGGGUGACGA-CAG--AAAAGCUACCC CAGGGA-UAACAGAGUUGUCCCCGGCGAGAGUACAUAUCGACCCGGGGGCUUGCUACCUC GAUGUCGGCUCUCCCCAUCCUGGCCGUGCAGCAGCGGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGGGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUGCUAUCUAACG --GGG--G-UGU------------------------------------------------ ----CAGGGCGG-CUGAGGGGAAG-GAGGCUCUAGUACGAGAGGAACGAGCCUCCGGCGC CAC-UGGUUUA-CCGGU-UGUCC-GGCA-GGGC-AU--CGCCGGGCAGCUA-C-GCGCCA CGC-GGUUAAAGGCUGAAAGCAUC--U-AAGCCUGAAACC------GCC-CCCGAAA--- --AGAGCCG---------------------------CC--CA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------A---AGGGC---UCCC--G-UAAAAGACGG-GG-UUGAUAGG ACCGG-GGUGUAAG-CGG-CGAGC---------------------UUCG------GC--G -AGCCGU--U--CAGCC-----CGCG----G-UCACUAA-UCGCCC-GC-----G-CCG- -------- >Caldivirga_maquilingensis -------ACCCGUGCCGCGAAGCCGUCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GAGGAAGGGCGUGGC-AAGCGGCGAUAUGCCCGGGGUAGCCGCAGG-CA-GGCGUU-GAU CCCGGGAUCCCCGAAUGGGGCU-UCCU--------------------------------- -------------ACCU------------------------------------------- ----------------------------------------GG------------GCCG-- AAUAGGCUCA-----GGU-------------GCCCCG-U--------------------- ------------------AG-GGGGUGGGA-ACGCGGGGAACGGAAACAUCUUAGUACCC --GCAGGAGGGGAAACCAAAA-GGGACCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GUU AGCCCAAA-CCGAACCCCCAUGG--GGU---AACCGUGGG--GGGAUGUGGUGUUU---- -----------------------------GGGCUUG--GGU------------------- -----------------ACCGC--CGAG----GCAGCCUAG------CCG-AAGUG-GGC UG-GA-------AAGCC------C-CGCC-GUAGAGGGUGAUAGCCCCGUAGGCUAAAGG --UUGC-UG---------GCG-----GAUUCCCAAUGUCCCGGAGUACCACGGCUU---G GUUUUGCCGUGGGAAUACGGGGGCCUCC-AGCCCCUAAGGCUAAGUACGU--CC-CGAGU CCGAUAGC-GAACAA-GUACCGUGAGGGAAAGCUGAAA-AGAAC-CCCGCGAGG-GGUGU GAAA-AGAGCCUGAAACCGGACGGUUA-AAG-GUGCG-GCGGCCCUCAAGGAU-AACCCC ACCUGAA-----------------------------------GGAAACCGG--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUGACCCGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGG----UGGGGUACGG-GGUCGCCGCUUACGUCCAGAAACACGAGCCAG GGAGUUCC-C----AUCUGUGGCGA---GUCUAA-GGG--G----------GUUAA---- --------CCCC-G-G-A-GGCGUAGGGAAA-CCGAA---------GGCCCGC----AGU CGGG----UUAA---CC-GAC-G----AGGGG-CUG---------------------GGU CCG---------------------------------------UUAA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------UAGCCACAGGUGGGA-GACCAGAAACCGA-GCGAUC UAGCCCGGGGUAGGGUGAAGCGGGG-CGAAAGC-CCCGUGGAGGCCCGAU-UGGG-GUUC UGACGUGCAAAUCGUUCCCGUGACCCUGGGCUAGGGGCAAAAGACCAAUCAAGCUCGG-U GAUAGCUGGUUCCCCCCGAAGCAGCUCUUAGGCUGGCCUCCCU-G--------------- ------------------------------------------------------------ -------------------GAGGG-UG-CUCAUGGGGUAGAGC-ACUGAUCCGG--GA-U GCAGG-GGC-C-GAAA--GGCUCC-GGUC-CCGGGUCAAACUCCGAACCCAUG-AG--C- C-C--------------------------------------------------------- ------------------------------------------------------------ -----CAU-UG--AA--G-GGGGG-AGA-CGGGUUC--CC-CGGGGGUAAGCUUGGG-GG -CCGAGA-GGGAA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--AAAGUG--C G-G-GC-U-AAG--UGUCAA-UCUA--G--AAGGGUGUCUCCCACCGAAGACGGCGGGAC CGUAGGCCCAG-CAGCAGCCAU-CGGCUAAGCAACGCGUAACAGCGGACCCGCU-----G AGGUGGGAGGCCCCGAAGACGCACAGGGACUC-A-AGCCC---GCC--------GCC--G AGA-CCCCGGC--C-C---A--C----GG-A---------------UC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUU------------------------------ ----------------G----A---------UCCG-C-GU--GG-GG--UAGGG----GG ---G-CGUC-GCCG-UG-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CGGA AGCCG-G--G-CCGU-GA-GGU--CCGG-U-GGA-CCCGCG-G--UGAAUGAGGAUCC-U GGCGG-UAGUA-GCAGC-G-AA-GAGGG-G------------------UGGGAUA----- ----------CCCCUC-CGCC-GGAAAGGCC-CAGGGUUCCA-UGGUAAUGUUCAUCAGC CAUGGG------------UUAGCCGG-UC-C-UAA----GGUG-G-GGCCUAA-UUGGCA C--------------------------C-C-A---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAC-GGG--U UAA----UAAU-CCC----GUGCC-G-UG-G--GGGU-A-G--G-UUU--G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------GG-CCCCAU-UCC-CG-AC--GUCU-C AGGAUA--GG--G-UGAGU-G-GGG--C-----UGCC------G---CC-CCAU--UU-- -A------ACC------GU-C------G------A--------A---G-----A--CCGG G-G------A---GU-G--C--C-----G--UCA-U-GGC-GAGAA-CC--GG----U-U -G--A--AGAC-G--G--U-A--A-UA-G-CCG-GGC----------------------- ---------CUUGA--------------------------------GC-CCG--GUU--- CA-C----CC-GACUC-C-UG-G-GGCC-CAUGAAA-A-G-GGAA---U--G-GGG-AA- ------------------------------------------------------------ -C--GAGC-CCC--CA-C-GACCGUACCGAGAACCGACACAGGU-CGCCUGGG-UGAGAA -G-CCCAAGG-CGGGU-CGGG-UCACGCCA-GGCUAGGGAACUCGGCAAAU-UAGCCCUG UAACUUCGGG-AUAAAGGGUGC-CC-GC--G-GU-CUGGG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U AA-AA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------C-C----- C------GG-G-A--C-CGUGG-GUCGCAGUGGCAAGGGGGACCUGA-----CUGUUUAA CAAAAACAUAGGUCCCCGC-GAGCCC--GU---A-A------------GGGUUU-GU-AC GGGGGCUG-AAUCCUGGCCACUGG-C-GGUACGUGAAA-CCCGGG------------UUC A--------------ACCGGG-CUAAGCGCCG-C-UGAAGGC-CGGGGGUAACUCUGACC CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGUGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCCAG-CC-UGG-UGCCCGGCGAACCCAC-CU-CCAGGUGCA GAGUCCUGGGACCCCCGACGGGGCGAGAAGA-CCCUGUGGACC-UUUACUGCAGCCCGUC GUUGGGGUGGGGGAGGGGGUGCAUAGUGU-AGGUGGGAG-CGAU----GAA--CCA--UG GUC--------------------------------------------------------- ----------------------------------UCCG--GGCCG--UGGGGAUG--CG- UCAA-UGAAACA-CCACCCAUCUCCU-CCUCUGCCCCUAA-CCC-U--GG--------G- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-UUC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------A-CCC-GGGGA -CAG-CGGCGGGUUGGCAGUUUGGCUGGGGCGGCACACCUCUGA-AAAGAUAUC-AGGGG UGCCCUAAGCUCCGCUCAGGUCGGUCAGAAA----CCGUA-GAGGGU-AAGGCCAAAU-G CGGGGCUGACUG-CCCCCUUGAAC--GCUAGGGGGGCAGGGGGGAAACCCGGGCCU-AGC G-AACGCUCG------------------------UG---------C-CCCC-ACU-GGA- ----------------------------GGGGGCCGGGCAUGU-CGG--AAAAGGUACCC CAGGAG-UAACCGGCUCGUCGCGGGUGAGAGUUCCCAUCGACCCCGCGGUUUGGUACCCA GACGUCGUCUCUUCCCAUCCUGGCGGUGCAGCAGCCGCCAAGGGUGGGGCUGCCCGCCCA UUAAAGGGGAACGUGAGAUGGGUUCAGACCGUCGUGAGACAGGUCGGUCUCUACCUGUCG --GGG--G-UGC------------------------------------------------ -----UGGCCGC-CUGAGGGGAAG-GUGCCCUCAGUACGAGAGGAACGGGGCGCCGCGGC CUC-UAGUCUA-CCGGU-UGUCC-GGCA-GGGC-AG--UGCCGGGCAGCCA-C-GCCGCU -UG-GGGUAACCGCUGAAGGCAUC--U-AAGCGGGAAACC------CGC-CCCUAAA--- --AUAGGCG---------------------------GC--CGC--------CG-C--C-- U-GACC-G-GG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUUA------------------------CCCGG --UUGGGGG-UGGU----U---AGGGC---UCCC--G-UAGAAGACGG-GG-UUGAUGGG GUGGU-GGUGUAUC-CCC-CGAGGG--------------------UUUU-----CCC--G -AGGGGG-----GAGCC-----UGCC----A-CUCCCAA-UCGCCC-GA-----U-G--- -------- >Haloarcula_marismortui ---------GUUGGCUACUAUGCCAGCU-GGUGGAUU-GCU-CGGCU-CAG-G--CGC-U GAUGAAGGACGUGCC-AAGCUGCGAUAAGCCAUGGGGAGCCGCACG-GA-GGCGAA-GAA CCAUGGAUUUCCGAAUGAGAAU-CUCU--------------------------------- -------------CUAA------------------------------------------- ----------------------------------------CA-------------AUU-G CU---------------------------------------------------------- ---------------UCGCG-CAAUGAGGA-ACCCCGAGAACUGAAACAUCUCAGUAUCG --GGAGGAACAGAAAACGCAAUGUGAUGUCGUUAGU-AAC-CGCGAGUGAACGCGA-UAC AGCCCAAA-CCGAAGCCCUCA----------------CGG--GCAAUGUGGUGUCA---- -----------------------------GGGCUACCU---------------------- ------CUCAUC-------AGC----CG----ACCGUCUCG------ACG-AAGUC-UCU UG-GA-------ACAGA------G-CGUG-AUACAGGGUGACAACCCCGUACUCGAG--A -CCAGU-AC---------G-------CUGUGCGGUAGUGCCAGAGUAGCGGGGGUU---G GAUAUCCCUCGCGAAUAACGCAGGCAUC-GACUGCGAAGGCUAAACACAA--CC-UGAGA CCGAUAGU-GAACAA-GUAGUGUGAACGAACGCUGCAA-AGUAC-CCUCAGAAGGGAGGC GAAAUAGAGCAUGAAAUCAGUUGGCGA-UCG-AGCGA-CAGGGCAUACAAGGU-CCCU-- UGACGAA-----------------------------------UGACCGACG--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGCGUCCAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAAGACUCA-CGGGAA--GCCGAUGUUCUGUCGUACGUUUUGAAAAACGAGCCAG GGAGUGUG-U----CUGCAUGGCAA---GUCUAA-CCG--G-A---------GUA----- -------UCCGG-G-G-A-GGCACAGGGAA-ACCGACA--------UGGCCGC----AGG GC-------UUU-----GCCC-G----AGGGC-CGC---------------------CGU CU----------------------------------------UCAA-------------- ---------------------------------------------GGGCG---------- ----------------------------------------GG------------------ ------------------------GAGCCAUGUGGACAC-GACCCGAAUCCGG-ACGAUC UACGCAUGGACAAGAUGAAGCGUGC-CGAAAGG-CACGUGGAAGUCUGUU-AGAG-UUGG UGUCCUACAAUACCCUCUCGUGAUCUAUGUGUAGGGGUGAAAGGCCCAUCGAGUCCGG-C AACAGCUGGUUCCAAUCGAAACAUGUCGAAGCAUGACCUCCGC-C--------------- ------------------------------------------------------------ -------------------GAGGU-AG-UCUGUGAGGUAGAGCGACCGAUUGGU-GUG-U CC-GC-CUC-C-GAGA--GGAGUC-GGCACACCUGUCAAACUCCAAACUUACA-GA--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGUUUG--AC--G-CGGGG-AUU-CCG-GUG--CG-CGGGG-UAAGCCUGUG-UA -CCAGGA-GGGGA----ACA--ACCCAGAGAUA--GGUUAAG--GUCCC--CAAGUG--U G-G-AU-U-AAG--UGUAA-UCCUCU-G--AAGGUGGUCUCGAGCCCUAGACAGCCGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUCUAAGAAAAGCGUAACAGCUUACCGGCC-----G AGGUUUGAGGCGCCCAAAAUG-AUCGGGACUC-A-AAUCC---ACC--------ACC--G AGA-CCUGUCC--GUA---C--C----A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------CUCAUAC--------------------------- ---------------------------------UG-G-UAAUCG-AG--UAGAU----UG ---G-CGCU-CUAAU-UG------------------GA-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGUAG-G--G-GUGA-AA-ACU--CCUA-U-GGA-CCGAUU-A--GUGACGAAAAUCC-U GGCCA-UAGUA-GCAGC-GAUA-GUCGG-G------------------UGAGAAC----- ----------CCCGAC-GGCC-UAA-UGGAU-AAGGGUUCCU-CAGCACUGCUGAUCAGC UGAGGG------------UUAGCCGG-UC-C-UAA----GUCA-U-ACCGCAA-CUCGAC U--------------------------A-U-G---------------------------- ------------------------------------------------------------ ----------------------------------AC---GAAAU-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUGCC-A-CU-A--UGCA----------------------- ----------------------------------------------------------GU GAAA-------------------------------------------------------- --------------------------------------------GU-UG-AC--GCCC-U GGGGUC--GA--U-CACGC-U-GGG--C------AUUC-----G---CC-CAGU--CG-- -A------ACC------GU-C------C------A--------A---C-----U--CCGU G-G------A----A-G--C--C-----G--UAA-U-GGC-AGGAA-GC--GG----A-C -G--A--ACGG-C--G--G-U--A-UA-G-G----------------------------- ---------GA-AA----------------------------------------CG---- UG-A----UU--CAAC-C-UG-G-GGCC-CAUGAAA-A-G-AC----------------- ------------------------------------------------------------ -----GAG-CAU--AG-U-GUCCGUACCGAGAACCGACACAGGUGUCCAUGGC-GGCGAA -A-GCCAAGG-CCUGU-CGGGAGCAACCAA-CGUUAGGGAAUUCGGCAAGU-UAGUCCCG UACCUUCGGA-AGAAGGGAUGC-CU-GC--U-CC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GA-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G--G-AGCAG-GUCGCAGUGACUCGGAAGCUCGGA-----CUGUCUAG UAACAACAUAGGUGACCGC-AAAUCC--GC---A-A------------GGACUC-GU-AC GGUCACUG-AAUCCUGCCCAGUGC-A-GGUAUCUGAAC-ACCUCG------------UAC A--------------AGAGGA-CGAAGGACCU-G-UCAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCA-UCAGUAGCGGCUUGCAUGAAUGGAUUAACC AG-A--GCUUC--ACUGUCCCAA-CG-UUG-GGCCCGGUGAACUGUACAU-UCCAGUGCG GAGUCUGGAGACACCCAGGGGGAAGCGAAGA-CCCUAUGGAGC-UUUACUGCAGGCUGUC GCUGAGACGUGGUCGCCGAUGUGCAGCAU-AGGUAGGAG-ACACUAC-ACA--GGU-ACC CGC--------------------------------------------------------- ----------------------------------GCUA--GCGGGCCACC-GAGU--CA- ACAG-UGAAAUA-CUACCCGUCGGUG-ACUGCGACUCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGGA -CAC-CGAUAGCCGGGCAGUUUGACUGGGGCGGUACGCGCUCGA-AAAGAUAUC-GAGCG CGCCCUAUGGCUAUCUCAGCCGGGACAGAGACCCGGCGAA-GAGUGC-AAGAGCAAAA-G AUAGCUUGACAG-UGUUCUUCCCAAC-G-AGGAACGCUGACGCGAAAGCGUGGUCU-AGC G-AACCAAUU------------------------AG---------C-CUGC--UU-GAU- ----------------------------GCGGGCAAUUGAUGA-CAG--AAAAGCUACCC UAGGGA-UAACAGAGUCGUCACUCGCAAGAGCACAUAUCGACCGAGUGGCUUGCUACCUC GAUGUCGGUUCCCUCCAUCCUGCCCGUGCAGAAGCGGGCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAUGUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGCUGCUAUCUACUG --GGU--G-UGU------------------------------------------------ ----AAUGGUGU-CUGACAAGAAC-GACCGUAUAGUACGAGAGGAACUACGGUUGGUGGC CAC-UGGUGUA-CCGGU-UGUUC-GAGA-GAGC-AC-GUGCCGGGUAGCCA-C-GCCACA -CG-GGGUAAGAGCUGAACGCAUC--U-AAGCUCGAAACC------CAC-UUGGAAA--- --AGAGACA---------------------------CC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CC------------------------------ ------------------G---AGGUC---CCGC--G-UACAAGACGC-GG-UCGAUAGA CUCGG-GGUGUGCG-CGU-CGAG----------------------GUAA-------C--G -AGACGU--U--AAGCC-----CACG----A-GCACUAA-CAGACC-AAA----G-CCAU -CAU---- >Halobacterium_sp. ----------GUGGCUACUGUGCCACCU-GGUGGAUA-GCU-CGGCU-CGG-A--UGC-C GACGAAGGACGUGCC-AAGCUGCGAUAAGCCUGAGGGAGCCGCACG-GA-GGCUAA-GAA CUCAGGAUCUCCUAAUGGGAAU-CCCU--------------------------------- -------------AUAA------------------------------------------- ----------------------------------------CA-------------AUU-G CC---------------------------------------------------------- ---------------UUGCG-CAAUGGGGA-ACGGCCGGAAUUGAAGCAUCUCAGUACGG --CCAGGAAGAGAAAUCGAAU-GAGACGCCGUUAGU-AAU-GGCGAAUGAACGCGG-CAC AGUCCAAA-CCGAAGCCUU------------------CGG--GCAAUGUGGUGUUC---- -----------------------------GGACUGACU---------------------- ------UUCAUC-------GUU----UG----ACCGUUCGU------GUG-AAGUC-UCC UG-AA-------ACGGA------G-CGCG-AUACAGGGUGACAGCCCCGUAUCACGG--A -CCAGU-AC---------G-------ACGUGCGUCAGCUCCAGAGUAGCGGGGGUU---G GAAAUCCCUCGUGAAUGUGGCAGGCAUC-GACUGCCAAGACUAAGUACUC--UC-CGAGA CCGAUAGU-GAACAA-GUAGUGUGAACGAACGCUGAAA-AGCAC-CCCACAAAGGGGGGU GAAAUAGGGCUUGAAAUCAGGUGGCGA-UGG-AGCGA-CGGGGCAUAAAAGGC-CUCU-- CUGGGAA--------------CGACUUG-----------AGUGCAAACUCA--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GGUAGGACCUGA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GAGGAGCCG-------------AUGUUCCGUCGUACGUUUUGAAAAACGAGCCAG GGAGUGUG-C----CUGUUUGACGA---GUCUAA-CCG--G-A---------GUA----- -------UCCGG-G-A-A-GGCGUAGGGAA-ACCAAUA--------UGGCCGC----AGC ---------AUU-------GC-G----AGGGC-CAC---------------------CGU GU----------------------------------------UCAA-------------- ---------------------------------------------GCGCG---------- ----------------------------------------GG------------------ ------------------------GAGUCAAACGGGCAC-GACCCGAAACCCG-GUGAUC UACGCGUGGGCAAGGUGAAGCAUGG-CGAAAGC-CAUGUGGAGGCCUGUU-AGGG-UUGG UGUCUUUCAACACCCUCCCGUGACCUACGUGUAGGGGUGAAAGGCCCAUCGAACCGGG-C AACAGCUGGUUCCAACCGAAACAUGUCGAAGCAUGACCUCUGC-C--------------- ------------------------------------------------------------ -------------------GAGGU-AG-UUCGUGGGGUAGAGCGACCGAUUGGG-GAG-U UC-AA-CUC-C-GAGA--GGAGUU-GUCUCCCCUGUCAAACUCCAAACCUACG-GA--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-CG--AC--G-CAGGG-AAU-CCG-GUG--UG-CGGGG-UAAGCCUGUG-CA -CCGUGA-GGGAG----ACA--ACCCAGAGUUA--GGUUAAG--GUCCC--AAAGUG--C G-A-GC-U-AAG--UGCGA-UU-----G--AAGGUGGUCUCGAGCCCUAGACAGCCGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUCUAAGAAAAGCGUAACAGCUUACCGGCC-----G AGGUUCGAGGCGCCCAAAAUG-AUCGGGGCUC-A-AGUUC---GCC--------ACC--G AGA-CCUAACG--GCA---C--G----GG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UAAC----------------------------- --------------------------------ACC-G-UGAUCC-AG--UAGGU----UG ---G-CAUU-CUGUU-CG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGCUC-G--G-GUGA-GA-ACU--CGAG-U-GGA-CCGAGU-G--GAAAAGAAAAUCC-U GGCCA-UAGUA-GCAGC-GUUA-GUCGG-G------------------UAAGAAU----- ----------CCCGAU-GGCC-GAA-AGAGC-AAGGGUUCCU-CGGCAAUGCUUAUCAGC CGAGGG------------UUAGCCGA-UC-C-UAA----GGCC-C-GUCGUAA-UUCGAG C--------------------------G-G-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---AA-AA-GGGA-AAC-UGG--U UAA----UAUU-CCA----GUGCC-A-CC-G--UACA----------------------- ----------------------------------------------------------UU GAAA-------------------------------------------------------- --------------------------------------------GU-CG-AC--GCCU-C GGAGCA--GC--U-UGAGC-C-GGG--C------AUUC-----G---CC-CGGU--CG-- -A------ACC------GU-C------G------A--------A---G-----U--UCGU G-G------A----A-G--C--C-----G--UAA-U-GGC-AGGAA-GC--GA----A-C -G--A--ACGU-C--G--G-A--A-CA-G-G----------------------------- ---------GA-AA----------------------------------------CU---- CA-A----GU--CAAU-C-UG-G-GGCC-CGUGAAA-A-G-GC----------------- ------------------------------------------------------------ -----GAG-UAC--GG-U-GUUCGUACCGAGAUCCGACACAGGUGCUCU-GGC-AGAGGA -A-GCCAAGG-CCUGU-CGGGAAUAACCGA-CGUUAGGGAAUUCGGCAAGU-UAGUCCCG UAAGUUCGCG-AUAAGGGAUGC-CU-GC--C-UC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G--A-GGCAG-GUCGCAGUGACUCGGAGGCUCCGA-----CUGUCUAA UAACAACAUAGGUGACCGC-AAAUCC--GC---A-A------------GGACGC-GU-AC GGUCACUG-AAUCCUGCCCAGUGC-G-GGUAUCUGAAC-ACCCAG------------UAC A--------------AUGGGG-CGAAGGACCC-G-UUAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCU-UCAGUAGCGGCUUGCAUGAAUGGAUCAACG AG-A--GCCUC--ACUGUCCCAA-CG-UUG-GGCCCGGUGAACUGUACGU-UCCAGUGCG GAGUCUGGAGACCCCCAAGGGGAAGCGAAGA-CCCUAUAGAGC-UUUACUGCAGGCUGUC GCUGGGACACGGUCGCUGAUGUGCAGAGU-AGGUAGGAG-ACGUUAC-ACA--GGU-ACG UGC--------------------------------------------------------- ----------------------------------GCUA--GCACGCCACC-GAGU--CA- CACA-UGAAACA-CUACCCGUCAGUG-ACUGUGACCCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGGA -CAC-CGGUAGCCGGGCAGUUUGACUGGGGCGGUACGCGCUUGA-AAAGAUAUC-GAGCG CGCCCUAAGCCUAUCUCAGCCGAGUCAGAGACUCGGCGAA-GAGUGC-AAGAGCAUAA-G AUAGGCUGACAG-UGUCCUACACAAC-G-AGGGACGCUGACGCGAAAGCGUGGUCU-AGC G-AACCAAUU------------------------AG---------G-CUGC--UU-GAU- ----------------------------GCGGCCAAUUGCUGA-CAG--AAAAGCUACCU UAGGGA-UAACAGAGUCGUCACUCGCAAGAGCACAUAUCGACCGAGUGGCUUGCUACCUC GAUGUCGGUUCCCUCCAUCCUGCCCGUGCAGAAGCGGGCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGGUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGCUGCUAUCUAUUG --GGG--G-UGU------------------------------------------------ ----UUUGGUGC-UUGACAGGAAC-GUUCGUAUAGUACGAGAGGAACUACGAACGGGUGC CAC-UGGUGUA-UCGGU-UGUCC-GAGA-GGGC-AU-GUGCCGAGCAGCUA-C-GCACCA -CG-GGGUAAGAGCUGAAUGCAUC--U-AAGCUCGAAACC------CAC-CUGGAAA--- --AGAAGCA---------------------------CC--A------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CU------------------------------ ------------------G---AGACC---GCUC--G-UAGAAGACGA-GU-UCGAUAGA CUUGG-GGUGUACG-CGU-CGAG----------------------GCAA-------C--G -AGACGU--U--UAGCC-----CGCG----A-GUACUAA-CAGGUC-AAU----G-CCAC -AC----- >Haloferax_volcanii -------CAACUGGCUACUGUGCCAGCU-GGUGGAUA-GCU-CGGCU-CGA-G--AGC-C GAUGACGGACGUGCC-AAGCUGCGAUAAGCCUCAGGGACCCGCAUG-GA-GGGAAA-GAA CUGAGGAUCUCCGAAUGGGAAU-CCCC--------------------------------- -------------ACGC------------------------------------------- ----------------------------------------AA-------------UUG-C C----------------------------------------------------------- ---------------UCGCG-CAAUGGGGA-ACGUUCCGAAUUGAAACAUCUUAGUAGGA --ACAGGAAAAGAAAGCAAUCCGCGAUGUCGUUAGU-AAC-GGCGAGUAAACGCGA-CAC AGUCCAAA-CCGAAGCCUU------------------CGG--GCAAUGUGGUGUAC---- -----------------------------GGACUACCC---------------------- ------AUAACG-------GAC----CU----GGGUCUUAU------GUG-AAGUC-UCC UG-GA-------ACGGA------G-CGUG-AUACAGGGUGAAAACCCCGUAACAUAAGAA -CCAGA--------------------UCCCGGGGUUGUUCCAGAAUAGCGGGGGUU---G GAUAUCCCUCGUGAAUUUCGCAGGCAUC-AACUGCGAAGACUAAACACUC--CU-CGAGA CCGAUAGC-GAACAA-GUAGCGUGAGCGAACGCUGAAA-AGCAC-CCCGAACAGGGCGGU GCAAUAGGGCUUGAAAUCAGUUGGCGA-UAG-AGCGA-CGUGGCAUACAAGGU-CACU-- CGACGAA-----------------------------------AGAACUGGG--A------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAUCCCGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAUGACUCG-AGUGAA--GCCGAUGUUACGUCGUACGUUUUGAAAAACGAACCAU GGAGUGCA-U----CUGACUGGCGA---GUCUAA-GGG--G-U---------GAAC---- --------CCCC-G-G-A-GGCAUAGGGAA-ACCGAUA--------CGGCCGC----AGU C--------UUU------GAC-C----AGGGC-CAC---------------------CGU CU----------------------------------------UCAA-------------- ---------------------------------------------GGGCG---------- ----------------------------------------GG------------------ ------------------------GAGCCAACCGGAUGC-GACCCGAAACCAA-GUGAUC UACGCCGGAGCAGGGCGAAGCGUGG-CGAAAGC-UGCGUGGAGGCCCGUU-AGAG-UUGG UGUCCUACAAUACCCUCUCGUGACUCUGGUGUAGGGGUGAAAGGCCCAUCGAACUUGG-C AACAGCUGGUUCCAACCGAAACAUGUCGAAGCAUGACCUCUGA-U--------------- ------------------------------------------------------------ -------------------GAGAU-AG-UUCGUGAGGUAGAGCGACCGAUUGGG-AAU-C CG-GA-CUC-C-GAGA--GGAGUU-CGCUUCCCUGUCAAACUCCGAACUUACG-AA--C- G-U--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AC--U-CAGGG-AGU-CCG-GUG--UG-CGGGG-UAAGCUUGUG-CA -CCGUGA-GGGAG----ACA--ACCCAGAGCCA--GGUUAAG--GACCC--AAAGUG--U G-G-AU-U-AAG--UGUGA-UU-----G--AAGAUUGUCUCGAGCCCUAAACAGCCGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUCUAAGAAUAGCGUAACAGCUUACCGGCC-----G AGGUUCGAGGCGUCGAAAAUG-AUCGGGACUC-A-AAUCC---ACC--------UCC--G AGA-CCUGGCG--GCG---U--G----UC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAU----------------------------- --------------------------------GAC-A-CGAUUC-CG--UAGGU----UG ---G-CAUA-CUGC-AUG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGCAC-G--G-GUGA-GA-ACU--CGUG-U-GGA-CCGUGC-A--GCAACGAAAAUCA-U GGUCU-CAGUA-GCAGC-GAGA-GUCGG-G------------------UGUGAAC----- ----------CCCGAC-GGCC-UUA-CGCGC-AAGGGUUCCU-CGGCACUGUCAAUCAGC CGAGGG------------UUAGUCGA-UC-C-UAA----GUCU-A-ACCGUAA-UUCGAA U--------------------------U-A-G---------------------------- ------------------------------------------------------------ ----------------------------------AU---GA-AA-GGGA-AAC-UGG--U UAA----UAUU-CCA----GUACC-U-UC-U--UGCA----------------------- ----------------------------------------------------------CC AAAC-------------------------------------------------------- --------------------------------------------GU-CG-AC--GCUU-U AGGAAA--CA--C-CGAGC-G-GGG--C------CUUC-----G---CC-CCGU--CG-- -A------AUC------AC-C------G------A--------A---A-----U--UCGU G-G------A----A-G--C--C-----G--UAA-C-GGC-ACGAA-GC--GA----A-C -G--A--ACGG-U--G--A-G--A-UA-G-G----------------------------- ---------GA-AA----------------------------------------CU---- CG-G----CG--GUAC-C-UA-G-AGCC-CGUGAAA-A-G-AC----------------- ------------------------------------------------------------ -----AAG-CAA--GA-A-GCUCGUACCGAGAUCCGACACAGGUGCGC-UGGC-AGAGCA -A-GCCAAGG-CCUGU-CGGGAUCAACCGA-CGUUAGGGAAUUCGGCAAGU-UAGUCCCG UAAGUUCGCG-AUAAGGGAUGC-CU-GC--U-CU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GA-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------C--G-AGCAG-GUCGCAGUGACUCGGACGCUCCGA-----CUGUCUAG UAACAACAUAGGUGACCGC-AAAUCC--GC---A-A------------GGACUC-GU-AC GGUCACUG-AAUCCUGCCCAGUGC-G-GGUAUCUGAAC-ACCCAU------------UAC A--------------AUGGGA-CGAAGGACCC-G-UCAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCU-UCAGUAGCGGCUUGCAUGAAUGGAUCAACG AG-A--GCGUC--ACUGUCCCAA-CG-UUG-GGCCCGGUGAACAGUACGU-UCCAGUGCG GAGUCUGGAGACCCCCAAGGGGAAGCGAAGA-CCCUAUAGAGC-UUUACUGCAGGCUGUC GCUGAGACGUGGUCGCUAAUGUGCAGCAU-AGGUAGGAG-CCAUUAC-ACA--GGU-ACC CGC--------------------------------------------------------- ----------------------------------GCCA--GCGGGCCACC-GAGG--CA- GCAU-UGAAAUA-CUACCCGUUAGUG-ACUGCGACUCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------UGGC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGGA -CAC-CGGUAGCCGGGCAGUUUGACUGGGGCGGUACGCGCUCGA-AAAGAUAUC-GAGCG CGCCCAAAGAUUUCCUCACGCGAGUCGGGAACUCGUGGAA-GAGCGC-AAGAGCAAAC-G GAAGUCUGACAG-UGACAUUCCCAAC-G-AGUGUCGCUGACGCGAAAGCGUGGUCU-AGC G-AACCUACG------------------------AG---------G-UUCA--UU-CAU- ----------------------------GGGACCCGUAGAUGA-CAG--AAAAGCUACCU UAGGGA-UAACAGAGUCGUCACCGGCAAGAGCACAUAUCGACCCGGUGGCUUGCUACCUC GAUGUCGGUUCCCUCCAUCCUGCCUGUGCAGAAGCAGGCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGGUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGCUGCUAUCUAUUG --GGG--G-UGU------------------------------------------------ ----UAAGGAAC-UUGACGUGAAC-GUUCGUAUAGUACGAGAGGAACUACGAAUGGGUGC CAC-UGGUGUA-CCGGU-UGUCC-GAGA-GGGC-AG-AUGCCGGGCAGCUA-C-GCACCA -CG-GGGUAAGAGCUGAACGCAUC--U-AAGCUCGAAACC------CAC-ACGGAAA--- --AGAAGUU---------------------------CC--A------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CU------------------------------ ------------------G---AGGAC---ACUC--G-UAGAAGACGA-GU-UCGAUAGA CUCGG-GGUGUACG-CAA-CGAG----------------------GUAA-------C--G -AGUUGU--U--AAGCC-----CGCG----A-GCACUAA-CAGUCC-AA-----G-CCAC -AUUC--- >Haloquadratum_walsbyi --------UACUGGCUACUGUACUGGCU-GGUGAAUG-GCU-CGGCU-CGA-G--AGC-C GAUGACGGACGUGCC-AAGCUGCGAAAAGCCUGAGGGAGCCGCACG-GA-GGCUAA-GAA CUCAGGAUCUCCGAAUGGGAAU-CCCC--------------------------------- -------------AUUG------------------------------------------- ----------------------------------------CG-------------AUU-A CGAGGUA----------------------------------------------------- ---------------UCUCG-UAAUCGGGA-ACGCCCCGAAUUGAAACAUCUUAGUAGGG --GCAGGAACAGAAAGCAACC-GCGAUAUCGUUAGU-AAC-CGCGAGUGAACACGA-CAC AGUCCAAA-CCGAAUCCGC------------------AAG--GAAAUGUGGUGUUU---- ----------------------------CGGACCAACA---------------------- ------AUCACG-------GAC----CG----CACGAUACC------GAG-AAAUC-UCC UG-GA-------ACGGA------G-UACG-ACACAGGGUGACAGUCCCGUAUCGUCAUCA -CGCGA--------------------UCCCGCGUUGACUCCAGAGUCGCAAGGGUU---G GCUAUCCCUUGUUAAUUCCGCAGACAUC-AACUGCGAAGACUACACACUC--CU-CGAGA CCGAUAGC-GAACAA-GUAGCGUGAGCGAACGCUGCAA-AGCAC-CCCGAACAGGGCGGU GCAAUAGGGCCUGAACUCAGUCAGUGA-UAG-AACGA-CGAGGCAUACAAGGU-CCCA-- CUCACAA------------------------------CGACCUGAGAGCA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AUCUCACUGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACGAGUG------GGAAGCCGAUGUCGCGUCGUACGUUUUGAAAAACGACCCAG GGAGUGCA-U----CCACCCGGCAA---GUCUAA-CUG--G-U---------CCAC---- --------CCAG-G-A-A-GACGCAGGGAA-ACCGAUA--------UGACCGC----AGU CAUGA---CUAC--UCAUGAC-C----AGGGU-CAC---------------------CGU AC----------------------------------------UUAC-------------- ---------------------------------------------AUGCG---------- ----------------------------------------GG------------------ ------------------------GAGUCGCGUGGAUGC-GACCCGAAACCGA-GUGAUC UACGCGCGGGCAAGGUGAAGCGUGC-CGAAAGG-UGCGUGGAAGCCUGUU-AGGG-AUGG UGUCCUACAAUACCCUCCCGUGACCCACGUGUAGGGGUGAAAGGCCCAUCGAACUCGG-C AACAGCUGGUUCCAGCCGACACAUAUCGAAGUAUGUCCUCAGC-C--------------- ------------------------------------------------------------ -------------------GAGGU-AG-UCUGCGAGGUAGAGCUACCGAUUGGA-UGU-C CC-GC-CUC-C-GAGA--GGAGUC-GGCCAUGCUGUCAAACUCCAAACUUGCA-GA--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AC--G-CUGGGAAUC-CGG-ACU--G--CGGGG-UAAGCCUGUG-GU -CCAUGA-GGGAG----ACA--ACCCAGAGCAG--GGUUAAG--GUCCC--CAAGUG--U G-G-AU-U-AAG--UGCAA-CU-----G--AAGGUUGUCUCGAGCCCUAAACAGCCGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUCUAAGAAAAGCGUAAUAGCUUACCGGCC-----G AGGUUCGAGGCGCCCAAAAUG-AUCGGGGCUC-A-AAUCC---ACC--------ACC--G AGA-CCCUGCA--AUA---C--U----UA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUAU----------------------------- --------------------------------CAA-G-UAACUU-CG--UAGGU-----G ---G-CGUA-CUGA-CCG------------------GA-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGUAC-G--G-GCGA-GA-GCU--CGUA-U-GGA-CCGCUC-A--GUAACGAUAAUCC-U GGUCA-CAGUA-GCAGC-AAUA-GUCGG-G------------------UGUGACC----- ----------CCCGAC-GGCC-UAA-CGAGC-AAGGGUUCCU-CGGCACUGCUAAUCAGC CGAGGG------------UUAGCCGG-UC-C-UAA----GUCU-G-ACCGUAA-UUCGAC U--------------------------C-A-G---------------------------- ------------------------------------------------------------ ----------------------------------AC---AAACA-GGGA-AAC-UGG--U UAA----UAUU-CCA----GUGCC-G-UC-G--UG------------------------- ----------------------------------------------------------UC UUAU-------------------------------------------------------- --------------------------------------------CG--A-AC--GCUU-U CGGAAA--CA--G-UGAAC-G-GGG--C------CAUC-----G---CC-CCGU--CG-- -A------AUC------AU-G------G------A--------A---U-----C--UCGU G-G------A----U-G--C--C-----G--UAA-C-GGC-ACGAA-GC--GG----G-A -G--A--AUCA-U--G--A-G--A-CC-G-C----------------------------- ---------GC-AA----------------------------------------GU---- CA------CU-GGUAC-C-AA-G-AGCC-CGUGAAA-A-A-AC----------------- ------------------------------------------------------------ -------A-CAC--GA-C-GUCCGUACCAAGAUCCGACACAGGUGCUCA-GGC-AGCGAA -A-GCCAUGG-CCCGU-CGGGACCAACCGG-CGUUAGGGAAUUCGGCAAGU-UAGUCCCG UACCUUCGGA-AGAAGGGAUGC-CU-GC--U-CU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U GA-C-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------C--G-AGCAG-GUCGCAGUGACUCGGACGCUCCGA-----CUGUCUAG UAACAACAUAGGUGACCGC-AAAUCC--GC---A-A------------GGACUC-GU-AC GGUCACUG-AAUCCUGCCCAGUGC-A-GGUAUCUGAAC-ACCUCG------------UAC A--------------AGAGGA-CGAAGGACCU-G-UUAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCU-UCAGUAGCGGCUUGCAUGAAUGGAUCAACG AG-A--GCGUC--ACUGUCCCAA-CG-CUG-GACCCGGUGAACUGUACGU-UCCAGUGCG GAGUCUGGAGACCCCCAAGGGGAAGCGAAGA-CCCUAUAGAGC-UUUACUGCAGGCUGUC GCUGAGACAUGGUCGCUGAUGUGCAGCAU-AGGUAGGAG-CCGAUAC-ACA--GGU-AUC CGC--------------------------------------------------------- ----------------------------------GCCA--GCGGAUCACC-GAGG--CA- CUCA-UGAAAUA-CUACCCGUCAGUG-ACUGUGACUCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAAAA -CAC-CGGUAGCCGGGCAGUUUGACUGGGGCGGUACGCGCUCGA-AAAGAUAUC-GAGCG CGCCCAAAGGUCUCCUCACGUGAGUCGGAAACUCACAGAC-GAGCGC-AAGAGCACAC-G GAGGCCUGACAG-UGAUCUUCCCAAC-G-AGGAUCGCUGACGCGAAAGCGUGGUCU-AGC G-AACCAACG------------------------AG---------G-UUCA--GA-GAU- ----------------------------GGGACCCGUUGAUGA-CAG--AAAAGCUACCU UAGGGA-UAACAGAGUCGUCACUCGCAAGAGCACAUAUCGACCGAGUGGCUUGCUACCUC GAUGUCGGUUCCCUCCAUCCUGCCUGUGCAGACGCAGGCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGGUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGCUGCUAUCUAUUG --GGG--G-UGU------------------------------------------------ -----AAGGUAC-UUGCGAGGAAC-GCUCGUAUAGUACGAGAGGAACUACGAGUGGGUGC CAC-UGGUGUA-UCGGU-UGUCC-GACA-GGGC-AG-UUGCCGAGCAGCCA-C-GCACCA -CA-GGGUAAGAGCUGAAUGCAUC--U-AAGCUCGAAACC------UCC-CUCAAAA--- --AGAAGUA---------------------------CC--A------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UGA----------------------------- ----------------------AGGAU---CCUU--C-UAGAAGAGAA-GG-UAGAUAGA CUCGG-GGUGUACG-CAU-CGAG----------------------GCAA-------C--G -AGAUGU--U--GAGCC-----CGCG----A-GCACUAA-CCAUCC-AA-----G-CCAU -AAUC--- >Halorubrum_lacusprofundi ----------------ACUGUGCCAGCU-GGUGAAUG-GCU-CGGCU-CGA-G--AGC-C GAUGAAGGACGUGCC-AAGCUGCGAAAAGCUCAUGGGACCCGCAUG-GA-GGGGAA-GAA CAUGAGAUAUCCGAAUCGGAAU-CCGU--------------------------------- -------------UUAC------------------------------------------- ----------------------------------------AA-------------UUG-C C----------------------------------------------------------- ---------------ACGCG-CAAUAGGGA-ACUCCCUGAAUUGAAACAUCUCAGUAAGG --GAAGGAAAAGAACGCAAUA-GCGAUGUCGUCAGU-AAC-CGCGAGUGAACGCGA-CAC AGCCCAAA-CCGAAGGUCUUC----------------GGA--CCAAUGUGGUGUUC---- -----------------------------GGGUUGACA---------------------- ------AUCAAU-------UCU----CG----ACAUUUCAU------CUG-AAGUC-UCC UG-GA-------AUGGA------G-CGUG-AAACAGGGUGACAACCCCGUAAGAUGA--G -ACAGU-AC---------G-------AA-GGCGUCAAUACCAGAGUAGCAGGGGUC---G GAUAUCCUCUGUGAACGACUCAGGCAUC-CCCUGAGAAGGCUAAACACUC--CU-CGAGA CCGAUAGC-GAACAA-GUAGCGUGAGCGAACGCUGAAA-AGCAC-CCCGAGAAGGGCGGU GCAAUAGGGCCUGAAAUCAGUUGGCGA-UCG-AGCGA-CAGGGCGUACAAGGC-GUCU-- CUUAAAA-----------------------------------CGAGCGAGA--A------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAUUCUCUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAGGAAGAG-AGACGA--GCCGGCGUCGUGUCGUGCGUUUUGAAAAACGACCCAG GGAGUGCA-C----UUGAUUGGCGA---GUCUAA-CCC--G-U---------GAAC---- --------CGGG-G-A-A-GGCGCAGGGAA-ACCGAUA--------CGGCCGC----AGC AC------AUUC-----GUGU-G----AGGGC-CAC---------------------CGU GU----------------------------------------UCAA-------------- ---------------------------------------------GCGCG---------- ----------------------------------------GG------------------ ------------------------GAGUCAAUUGGGUGC-GACCCGAAACCAG-GCGAUC UAUACACAGGCAGGGUGAAGCGUGG-CGAAAGC-CACGUGGAGGCCCGUU-AGAG-UUGG UAUUCUACAAUAUCCUCUCGUGAUCUGUGCAUAGGGGUGAAAGGCCCAUCGAGCCUGG-C AACAGCUGGUUCCAACCGAAACAUGUCGAAGCAUGACCUCAUC-C--------------- ------------------------------------------------------------ -------------------GAGAU-AG-CCCGCGGGGUAGAGCUACCGAUUGGA-UGA-C CC-GC-CUC-C-GAGA--GGAGUC-GGCCAUCCUGUCGAACUCCAAACCCGCA-GG--C- G-U--------------------------------------------------------- ------------------------------------------------------------ -----UGU-AG--AC--G-AUGGG-AGU-CCG-GUG--CG-CGGGG-UAAGCCUGUG-UA -CCGUGA-GGGGA----ACA--ACCCAGAGCCG--GGUUAAG--GUCCC--AAAGUG--U A-G-AU-U-AAG--UGCGA--C-----G--AAGGUGGUCUCAAGCCCUAAACAGCCGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUCUAAGAAAAGCGUAACAGCUUACCGGCC-----G AGGUUUGAGGCGCCCAAAAUG-AUCGGGGCUC-A-AAUCU---ACC--------ACC--G AGA-CCUGGCC--GUG---C--C----CU------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UGACAG--------------------------- ---------------------------------GG-G-CAACCG-CG--UAGGU----UG ---G-CGUU-CUGUU-CG------------------GA-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGCAC-G--G-GUGA-GA-ACU--CGUG-U-GGA-CCGUUC-A--GAAACGACAAUCC-U GGUCA-CAGUA-GCAGC-GAUA-GUCGG-G------------------UGAGAAC----- ----------CUCGAC-GGCC-UGA-AGAGC-AAGGGUUCCU-CGGCACUGCCACUCAGC CGAGGG------------UCAGCCGG-UC-C-UAA----GAUG-C-ACCGUAA-CUCGAC U--------------------------G-C-A---------------------------- ------------------------------------------------------------ ----------------------------------UC---AA-C--GGGA-AAC-UGG--U UAA----GAUU-CCA----GUGCC-A-UC-G--UGCA----------------------- ----------------------------------------------------------GU AAAC-------------------------------------------------------- --------------------------------------------GU-CG-AC--GCCG-U GUGGAA--CG--C-UGAGC-C-GGG--C------UUUC-----G---CC-CGGU--CG-- -A------AUC------GU-G------G------A--------A---A-----C--UCGU G-G------A----A-G--C--C-----G--UCA-C-GGC-ACGAA-GC--GA----G-C -G--A--AACG-C--G--A-G--A-UA-G-C----------------------------- ---------GC-AA----------------------------------------GU---- CA-G----CC-GUA-C-A-UA-G-GGCC-CGUGAAA-A-G-AC----------------- ------------------------------------------------------------ -----AAG-CAC--GA-U-GUCCGUACCAAGAUCCGACACAGGUGCUC-UGGC-AGCGCA -A-GCCAAGG-CCUGU-CGGGA-GAACCGA-CGUUAGGGAAUUCGGCAAGU-UAGUCCCG UACCUUCGGA-AGAAGGGAUGC-CU-GC--U-CU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ CG-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G--G-AGCAG-GUCGCAGUGACUCGGGCGCUCCGA-----CUGUCUAA UAACAACACAGGUGACCGC-AAAUCC--GC---A-A------------GGACUC-GU-AC GGUCACUG-AAUCCUGCCCAGUGC-G-GGUAUCUGAAC-ACCUCG------------UAC A--------------AGAGGA-CGAAGGACCC-G-UCAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCU-UCAGUAGCGGCUUGCAUGAAUGGAUAAACG AG-A--GCGCC--ACUGUCCCAA-CG-UUG-GACCCGGUGAACUGUACGU-UCCAGUGCG GAGUCUGGAGACCCCCAAGGGGAAGCGAAGA-CCCUAUAGAGC-UUUACUGCAGGCUGUC GCUGAGACGUGGUCGCCGAUGUGCAGCAU-AGGUAGGAG-UCAUUAC-ACA--GGU-ACC CGC--------------------------------------------------------- ----------------------------------GCCA--GCGGGCCACC-GAGA--CA- ACAU-UGAAAUA-CUACCCGUCGGUG-ACUGCGACUCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGUA -CAC-CGGUAGCCGGGCAGUUUGACUGGGGCGGUACGCGCUCGA-AAAGAUAUC-GAGCG CGCCCGAAGAUCAUCUCAGCCGGGUCGGAAAUCCGGCGAA-GAGCGC-AAGAGCACAA-G AUGGUCUGACAG-UGUCAUUCCCAAC-G-AGUGACGCUGACGCGAAAGCGUGGUCU-AGC G-AACCUACG------------------------AG---------G-CUCC--GG-AAU- ----------------------------GGGGCCCGUAGAUGA-CAG--AAAAGCUACCU UAGGGA-UAACAGAGUCGUCACCCGCAAGAGCACAUAUCGACCGGGUGGCUUGCUACCUC GAUGUCGGUUCCCUCCAUCCUGCCCGUGCAGAAGCGGGCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGGUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGCUGCUAUCUAUUG --GGG--G-UGU------------------------------------------------ ----CAAGGUAC-UUGACGUGAAC-GAACGUAUAGUACGAGAGGAACUACGUUUGGUCGC CAC-UGGUGUA-CCGGU-UGUGU-GAGA-ACGC-AA--UGCCGGGUAGCCA-C-GCGACA -CG-GGGUAAGAGCUGAACGCAUC--U-AAGCUCGAAACC------CAC-AUGGAAA--- --AGAAGUA---------------------------CC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AU------------------------------ ------------------G---AGGUC---ACUC--G-UAGAAGACGA-GU-UCGAUAGA CUCGG-GAUGUACG-CAC-CGAG----------------------GCAA-------C--G -AGGUGU--U--GAGUC-----CACG----A-GCACUAA-CAGACC-GAA----G-CCAC -AGUC--- >Hyperthermus_butylicus --------UCACGGCACGGACGCCGCCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GACGAAGGGCGCGGC-AAGCGGCGAUAUGCCCGGGGUAGGCGCAGG-CA-GCCGUG-GAA CCCGGGAUCCCCGAAUGGGGCC-UCCC--------------------------------- -------------GCCA------------------------------------------- ----------------------------------------CG-------------GGC-G AAUAGCCCGU-----GGC-------------GCUCGG-G-AAACCGUUAGGG-------- ---------------AGUAC-CGAGUGGGA-ACCCCCCGAACGGAAACAUCUUAGUAGGG --GGAGGAAAAGAAAGCAACA-GCGAUCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAG AGCCCAAA-CCAAUCCUCCGCGG--GAU---AACCGCGGA--GGGAUGAGGGGUUG---- ----------------------------CGGCCCCGCGGCUGG--------GGCU----- ------UCGAGCCCCAGCGGGC--CGAC----CCCGGGUAG------CCG-AAGUG-GGC UG-GA-------AAGCC------C-CGCC-GUAGAGGGUGACAGCCCCGUAGGCUAAACC --CGGG-GG---------GCC-----CGCGCCGC--GGGGCAGAGUACCACGGCUU---G GUUCUGCCGUGGGAAGCUGGGAGUCACC-GACUCCCAAGGCUAAAUACGU--CC-CGAGA CCGAUAGC-GAACUA-GUACCGUGAGGGAACGCUGAAA-AGCAC-CCCGGAAGG-GGGGU GAAA-AGAGCCUGAAACCGGGCGGCUA-AGC-ACGGG-GCGGCCCGAAAGGGAGGAGGCC CCCCGAA-----------------------------------GGAAACCGG--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGCCGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG-GGCGG---ACCGGGGUCGCCCCGUCCGUCUUGAAACACGGGCCGG GGAGUUCA-C----GGCCGUGGCGA---GCCUAA-GGG--G-U---------UCAC---- --------CCCC-G-A-A-GGCGCAGGGAAA-CCGACG--------AGCCCGC----AGC CGGGG---GUUC---CCCGGC-G----AGGGG-CGG---------------------GGU CC----------------------------------------GAAA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACGGCCGUGA-GACCAGAAACCGG-GCGAUC UAGGCGGGGGCAGGGUGAAGCCGGG-CGAAAGC-CCGGUGGAGGCCCGA--AGGG-GUUC UGACGUGCAAUUCGUUCCCCUGACCCCCGUCUAGGGGUGAAAGGCCAAUCUAGCCCGG-U GAUAGCUGGUUCCCGCCGAAGUGCCUCGCAGGGCAGCCCCGCC-G--------------- ------------------------------------------------------------ -------------------GAGGCCGG-GCCGCGGGGUAGAGC-ACUGAUUGGG--GG-U GCAGG-GGG-C-GUAAU-GCCCCC-GGCC-CCCUAUCAAACUCCGAACCCGCG-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-GCGGG-AGU-GGGGCUC--CC-CGGGG-UAAGCCCGGG-GG -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--CAAGGG--C C-G-GC-U-AAG--UGCCAA-CG----A--AAGGGCGUCCUCGGCCUCAGACAGCGGGGA GGUGGGCCUAA-CAGCAGCCAU-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGGCCGAGGGCCCCGAAGAUAUGUCGGGGCUU-A-AGCCG---GCC--------GCC--G AAA-CCCCGGG--GGC---G--G----GC-C---------------GC-U---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUGC----------------------------- ----------------G----G---------CCCG-C-A-U-CC-GG--UAGGC----GG ---G-CGUC-GGGG-CG-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGGCG-G--G-CCGU-GA-GGC--CCGC-U-GGA-GCCGCC-C--CGAGUGCGGAUCC-C GGCGG-UAGUA-ACAGC-G-AA-GAGGG-G------------------UGAGAAU----- ----------CCCCUC-CGCC-GGAAAGGGC-AAGGGUUCCU-CGGCAACGGUCGUCGGC CGAGGG------------UGAGCCGG-CC-C-UAA----CCGG-G-GCCGUAA-CACGGA C--------------------------C-C-C---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AA-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUGCC-G-CG-G--GGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AG-CCCCGC-CUC-CG-AC--GCCU-C CGGGUA--GG--C-CGACC-G-GGG--GCGGCCGAAG-GGCCGCG--AC-CCGG--CU-- -A------ACC------GC-U------G------A--------A---G-----G--CCGG G-G------A---GU-G--C--C-----G--UAA-U-GGC-GAGAA-CC--GG----C-C -G--A--AGGC-G--G--G-A--A-UG-G-GGG-GCC----------------------- ---------GU-UA--------------------------------GG-CCC--CUU--- CG-G----CC-GAUCC-C-GG-G-GGCC-CUUGAAA-A-G-GGGG---C--G-GGG-AA- ------------------------------------------------------------ -C--GAUC-CCC--CG-C-GCCCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAGAA -G-CCCCAGG-CGUCU-GGGGGGCAACCCG-GGCCAGGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CC-GC--G-GU-CUGGGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U AG-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------C-C----- C-----CUG-G-A--C-CGCGG-GUCGCAGUGCCUAGGGGGGCCUGA-----CUGUUUAA UAAAAACAUAGGUCCCCGC-AAGCCC--GA---A-A------------GGGUGU-GU-AC GGGGGCCG-AAUCCUGGCCACUGG-C-GGUCCGUGAAA-CCGGGG------------UUC A--------------ACCCGG-CGAAGCGCCG-C-UGAAGGC-CGGGAGUAACUCUGACU CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGCGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCUGG-CC-CGG-GGCCCCGUGAACCCACGGA-GCCGGUGCA CAGGCCGGCAUCCCCCCGCAGGGCGAGAAGA-CCCCGUGGAGC-UUUACCGCAGCCUGGG GUUGCCCUUCGGGCCUGGGUGCGUAGCGU-AGGUGGGAG-CC-GA-U-GAG--CCA--CC CUC--------------------------------------------------------- ----------------------------------UCCG--GGGGG--UGGGGAGG--CG- CCAA-UGAAACA-CCACCCACCCAGG-CCCGGGGGGCUUA-CCC-C--CG--------G- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------C-GGGAA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------G-C-CGG-GGGGA -CAG-CCCCAGGUGGGCGGUUUGGCUGGGGCGGCACGCCCGCGA-AAAGGUAAC-ACGGG CGCCCAAAGGUCGGCUCAGGCGGGUCAGAGCUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACCG-GACCCCUAAAA--GCAGGGGGUCCGGCCGGGAAACCGCGGCCU-AGC G-AACGCUCG------------------------UG---------C-CCCC-CUC-GGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC CGGGGA-UAACAGAGUCGUCGCGGGCGAGAGCUCCCAUCGACCCCGCGGUUUGCUACAUC GAUGUCGGCUCUUCCCAUCCUGGGGGUGCAGCAGCCCCCAAGGGUGGGGCUGCCCGCCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGACUCUACCCGCGG --GGG--G-UGU------------------------------------------------ -----GGGCCGC-CUGAGGGGAAG-GUGCCCCUAGUACGAGAGGAACGGGGCGCCGCGGC CUC-UAGUGUA-CCGGU-UGUCC-GGCA-GGGC-AG--CGCCGGGUAGCCA-C-GCCGUA -GG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CUC-CCCGAAA--- --AGAGGCG---------------------------GC--CG---------CC-A--G-- C--CCG-G-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCCA----------------------------- --CCCGGGC-UGGC----C---CGGGC---UCCC--G-UAGAAGACGG-GG-UUGAUGGG GCGGG-GGUGUAAG-CCC-CGAGGG----C---------------GUUA--GG-CCC--G -AGGGGU--U--CAGCC-----CGCC----G-CUCCCAA-UCGCCC-GG--A-------- -------- >Ignicoccus_hospitalis --------------CGCGUAAGCCGCCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GACGAAGGGCGUGGC-AAGCUGCGAUAAGCCCGGGGGAGGCGCACG-CA-GCCGUC-GAA CCCGGGAUCCCCGAAUGGGACU-UCCU--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------GG-------------GGC-G AACAGCCCCC-----GGC-------------GCGGGG-A-GAA----------------- ---------------------CCCGCGGGA-ACCCCCCGAACGGAAACAUCUUAGUAGGG --GGAGGAAGAGAAACCACCACGGGAUCCCCCGAGU-AGG-GGCGACCGAAAGGGG-GGU AGCCCAAA-CCAAUUCCCCACGG--GAU---AACCGUGGG--GAGAUGAGGGGUGG---- ----------------------------AUGCCCCGCGGCUCC--------CCC------ ------UCGAGGG-GAGGGGCC--CGAC----CCUCGGUAC------CCG-AACUC-CGG UG-GA-------AC-CG------G-GGCC-GUAGAGGGUGACAGCCCCGUAGGGGAAACC --GAGG-GG---------GGC-----CCUGCCGC--GGGGAUGAGUACCACGGCUU---G GUAUUGCCGUGGGAAGCUGGGUGGCACC-AGCAUCCAAGGCUAAACACGU--CC-CGAGA CCGAUAGC-GAACUAGGUACCGUGAGGGAAAGCUGAAA-AGCAC-CCCUGGCGG-GGGGU GAAA-AGAGCCUGAAACCGGGCGGUCA-CAC-AGGGU-GCGGCCCGCAAGGGAUGAAGC- CCCGGAA-----------------------------------GGAAACCCG--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACCGGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGUGGG----UGCAGACCGG-GGUCGCACCUUUCGUCUUGAAACACGGGCCGG GGAGUGCA-C----GGCCGUGGCGA---GGCUAA-GGG--G-U---------UCA----- -------CCCCC-G-U-A-ACCGCAGGGAAA-CCGACG--------AGCCCGC----AG- GGGC----UCAU--GCCC--C-G----AGGGG-CGG---------------------GGU CC----------------------------------------GCAA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACGGUCGUGC-GACCCGAAACCGG-GCGAUC UAGGCGGGGGCAGGGUGAAGCCGGG-CGAAAGC-CCGGUGGAGGCCCGCA-AGGG--UUC UGACGUGCAAUUCGUUCCCCUGACCUCCGCCUAGGGGUGAAAGGCCAAUCUAGCUCGG-U GAUAGCUGGUUCCCGCCGAAGUGGGUCUAAGCCCAGCGUCCCC-G--------------- ------------------------------------------------------------ -------------------GAGGC-GG-GCCACGGGGUAGAGCUACUGAUGGGA-GGU-G CAGGG-GGG-C-GUAG--GCCCCC-GGCC-UCCCGUCAAACUCCGAACCCGUG-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AA--G-GGGGC-AGU-GGG-GCG--CCCCGGGG-UAAGCCCGGG-GG -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--CAAGUG--C C-G-GC-U-AAG--UGCCAA-CCG---A--AAGGGCGUCUCGGGCCUCAGACAGCGGGGA GGUGGGCCUAA-CAGCAGCCAC-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGGCCCGAGGCCCCGAAGAUUGGUCGGGGCUU-A-AGCCG---GCC--------GCC--G AGA-CCCCGGG--C-C---C--C----CC-U---------------CC-C---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGU------------------------------ ---------------GG----G---------AGGG-G-GU--GC-GG--UAGGC----GG ---G-CGUC-GGGG-CG-------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGGCG-G--G-CCGU-GA-GGU--CCGC-U-GGA-GCCGCU-C--CGAGUGCCGAUCC-C GGCGG-UAGUA-ACAGC-G-AA-GAGGG-G------------------UGAGAAU----- ----------CCCCUC-CGCC-GGAAAGGGC-AAGGGUUCCC-CGGCAACUGUCAUAGGC CGGGGG------------UGAGUCGG-UC-C-UAA----CCCG-C-CUCCCAA-CUGGAG C--------------------------G-C-G---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AA-GGGA-AGC-CGG--U UAA----UAUU-CCG----GCACC-G-CG-G--GGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AG-CCCCAC-CUC-CG-AC--GCCU-C GGGGUA--GG--C-GGACC-G-GGG--C-----UGUC------G---CC-CCGG--CU-- -A------ACC-------C-C------G------A--------A---G-----G--CCCU G-G------A---GG-G--C--C-----G--UAA-C-GGC-GAGAA-GG--GG----C-C -G--A--AGGC-G--G--G-A--A-GG-G-GCC-CCC----------------------- ---------GU-AU--------------------------------GG-GGG--CUU--- CC-G----CC-GAUCC-C-UG-G-GGCC-CAUGAAA-A-G-GGGG---U--G-GGG-AA- ------------------------------------------------------------ -C--GAUC-CCC--CG-C-GCCCGUACCGAGAACCGACGCAGGUGCCCCUGGG-UGAGAA -G-CCCAAGG-CGGCU-GGGGGUUAACCCG-GGCCAGGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-GC--G-GU-CCUGGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C CC-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------C-C----- C-----UGG-G-A--C-CGCAG-GUUGCAGUGCCUAGGGGGGCCUGA-----CUGUUUAA UAAAAACAUAGGUCCCCGC-AAGCCC--GA---A-A------------GGGUGU-GU-AC GGGGGCCG-AAUCCUGGCCACUGG-C-GGUCCGUGAAA-CCGGGG------------UUC A--------------ACCCGG-CGAAGCGCCG-C-UGAAGGC-CGGGAGUAACUCUGACU CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGCGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCCGG-CC-CGG-GGCCCCGUGAACCCCCUGA-GCCGGUGCA CAGUCCGGCAACCCCCCGUAGGGAGAGAAGA-CCCCGUGGAGC-UUUACUGCAGCCCGGC GUUGCCCCCCGGGUGGGGGUGCGUAGCGU-AGGUGGGAG-CC-GG-U-GAA--CCG--GC CCC--------------------------------------------------------- ----------------------------------UCCG--GGGGU--CGGGGAGG--CG- CCCA-UGAAACA-CCACCCACCCUCA-CCCGGGGGGCUUA-CCC-C--G----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GGGAA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------G-C-CCG-GGGGA -CAG-CGCCGGGUGGGCAGUUUGGCUGGGGCGGCACGCCCGCGA-GAGGGUAAC-ACGGG CGCCCUAAGGUCGGCUCAGGCGGGUCAGAAACCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACCG-GACCCCUAAAG--GCAGGGGGUCCGGCCGGGAAACCGCGGCCU-AGC G-AACGCUCG------------------------UG---------U-CCCC-CCU-GGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC CGGGGA-UAACAGAGUCGUCGCGGGCGAGAGCCCACAUCGACCCCGCGGUUUGCUACCUC GAUGUCGGCUUUUCCCAUCCUGGGGGUGCAGCAGCCCCCAAGGGUGGGGCUGCCCGCCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGACUCUACCCACGG --GGG--G-UGU------------------------------------------------ -----CGGCCGC-CUGAGGGGAAG-GUGCCCUCAGUACGAGAGGAACGGGGCGCCCCGGC CUC-UGGUGUA-CCGGU-UGUCC-GGCA-GGGC-AG-A-GCCGGGCAGCUA-C-GCCGGA -AG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CAC-CCCGAAA--- --AGAGGCG---------------------------GC--CAU--------UG-A--G-- G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GC-----------UCCC--G-UAGAAGACGG-GG-UUGAUGGG GCGGG-GGUGUAAG-CCCCGAGGGG--------------------UUUC-----CC---G -AGGGGC--G--AGCCC-----GCCG------CUCCCAA-UCGCCC-GA--GGCCGUUAG C------- >Metallosphaera_sedula -------GCUAGGGACAAGAAGUCGUCC-GGUGGAUG-GCU-CGGCU-CAG-G--GGC-C UAAGAAGGGCGCGGC-AAGCGGCGAAAUGCCCAGGGGAGGCGCACG-CA-GCCUUA-GAU CCUGGGAUCCCCGAAUGGGAAU-UCCU--------------------------------- -------------GCCU------------------------------------------- ----------------------------------------GG-------------AGU-U AACAGCUCCA-----GGC-------------GUCCCG-U--------------------- ------------------AA-GGGACGGGA-ACCCCCCGAACGGAAGCAUCUUAGUAGGG --GGAGGAGGAGAAAUCAAUU-GAGAUUCCCUGAGU-AGG-GGCGACCGAAAGGGG-AAC AGCCCAAA-CCAAAUCCGCUAGU--GAC---GAGCUGGCG--GAGAUGUGGUGUUU---- ----------------------------CUGGCCCUGGGUCAG--------GGG------ --------CAACC-CAGCCUCC--GGUG----UCUGGAUAG------CCG-AAUUC-ACC UG-GA-------AAGGU------G-AGCC-AUAGAGGGUGACAGCCCCGUAGGCGAAAUC --CAGG-CG---------GGA-----GGUGGCCC--AGGGCAGAGUACCAUCCCCU---G GUUUGGGGGUGGGAAGAUGGGAGACACG-UGCUUCCAAGGCUAAAUACUU--CC-UGAGA CCGAUAGC-GAACUCAGUACUGUGAAGGAAAGCUGAAA-AGCAC-CCCGGAAGG-GGAGU GAAA-AGUGCCUGAAACCGGGCGAUUA-CAC-AGGGC-AAGGCCCUGAAGGGCUGACUUC CCCCGAA-----------------------------------GGAAAGGGA--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCAAGUCCUCAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG-GAAUG---ACCAGGGUCUUGCUUUUCGUCUUGAAACACGGGCCGG GGAGGUCA-C----GUCAGUGGCGA---GCCUAA-GGU--G----------GUCAG---- --------CACC-G-A-A-GGCAAAGGGAAA-CCGAG---------GAUCCGC----AAC CCGG----GAAA---CCGGGU-G----AGGGA-UCG---------------------GGU CU----------------------------------------GUCA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------UU------------------ ------------------------GAGUCACUGGCGUGA-AACUAGAAACCGG-GCGAUC UAGACCUGGGCAGGUCGAAGUCGGG-GGAAACC-CCGAUGGAGGACCGAAUAGGG-GUUC UGACGUGCAAUUCGUUCCCUUGACCUGGGUCUAGGGGCAAAAGACCAAUCUAGCCCGG-U GAUAUCUAGUUCCCUCCGAAAUGCGUCCUAGCGCAGCCUCCCU-G--------------- ------------------------------------------------------------ -------------------GAGGU-UG-CUCAUGGGGUAGAGAUACUGAUUGGG--GG-C CU--C-UGA-C-GAAA--GUCAGG-GGAA-CCCAGUCAAACUCCGAACCCAUG-GG--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CAG-AG--AA--G-GGGGG-AGU-GGA-UCA--CC-CGGCG-UAAGGUUGGG-UG -GUAAGA-GGGGA----ACA--ACCCAGACCCG--GGUUAAG--GUCCC--CAAGUA--C U-G-GC-U-AAG--UGCGAA-UCUG--G--AAGGGCGUCCCAUGCCUAAGACAGCGGGAA GGUGGGCCCAG-CAGCAGCCAU-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGGCCUGGGGCCCUGCAGACUAGUCGGGGCUC-A-AGCCA---GUC--------ACC--G AUA-CCCGGGG--GGU---G--G----CG-C---------------UC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUU------------------------------ ----------------G----A---------GUGU-C-A-C-CC-GG--UAGGG----GG ---G-CGCC-GCGG-UG-------------------GG-C-------------------- ------------------------------------------------------------ --------------------------------------------------------GAGA AGGUG-G--G-CCGU-GA-GGU--CCAC-U-GGA-CCCUCC-G--CGGGUGCAGAUCC-C GGCGG-CAGUA-AUAGC-G-AA-GGAGG-G------------------UGAGAAU----- ----------CCCUCC-CGCC-GAA-AGGGC-AAGGGUUUCC-CGGCAAUGUUCGUCAAC CGGGAG------------UUAGCCGG-UC-C-UAA----GGCA-G-GGCCUAA-CUGGUA C--------------------------C-U-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA-AA-GGGA-AAG-GGG--U UAA----UAUU-CCC----CUGCC-A-CG-G--GGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-U----------------------GCGGGGAUC-UCC-UG-AC--GGAU-C GAGGUA--CG--G-GGAGU-G-GGG--C-----CAUC------G---CC-CCAU--CC-- -A------AGU------AC-C------G------A--------A---G-----U--CCCU G-G------A---GA-G--C--C-----G--UAA-U-GGU-GAGAA-GG--GG----A-C -G--A--AGGC-U--C--G-A--U-GG-G-CCU-UCC----------------------- ---------GU-UA--------------------------------GG-AGG--GUU--- CU-C----CG-GAUCC-U-UG-G-UCCC-CAUGAAA-A-G-GGAG---A--U-CCC-AA- ------------------------------------------------------------ -C--GAUC-CUC--CG-U-GACCGUACCCAGAACCGACACUGGUGCCCCUGGG-UGAGAA -G-CCCAAGG-CGUCU-GGGGGGUAACUCA-GGCUAGGGAACUCGGCAAAA-UGGUCCCG UACCUUCGGA-AGAAGGGAUGC-CU-AC--C-AU-UGUAG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UA-CG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ C-----UGC-A-G--U-GGUAG-GUCGCAGUGACCAGGGGGAUCUGA-----CUAUUUAA UAAAAAUAUAGGUCCCCGC-UAGCCC--GA---A-A------------GGGUGU-GA-AC GGGGGCUA-AAUCCUGGCCACUGG-C-GGUCGGUUAAA-CCCGGG------------UCC A--------------ACCGGG-CGAAGCCCCG-C-UGAAGGC-CGGGGGUAACUCUGACC CUCUCAAGGUAGCCAAAUGCCUUGCCGGG-CAAGUUCCGGCGCGCAUGAAUGGAUCAACG UG-A--UCCCC--ACUGUCCCAG-CC-UGG-GGCCCCAUGACCGCCCAGA-GUGGGUUCA CAGUCCCGCAACUCCUCACACCGAGAGAAGA-CCCCGUGGAGC-UUCACCGCAGCCUGGC GCUGGUUCUCGGGCGUUCAUGCGUAGCGU-AGGUGGGAG-GCGU--C-GAA--GUC--GU CCC--------------------------------------------------------- ----------------------------------UUCG--GGGGC--GAUGGAGC--CG- CAAG-UGAAACA-CCACCCAUGAAUG-CUCGGGAACCUAA-CCU---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-CGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AGGGA -CAA-CGUCAGGUGGGCGGUUCGGCUGGGGCGGCACUCCCGCGA-AAAGAUAAC-ACGGG AGCCCAAAGGUCAGCUCAGGCGGUACAGAACGCCGCCGUA-GAGUGC-AAGGGCAAAA-G CUGGCCUGACGA-GACCCUUCAAA--GUACGGGGUCUCGACGCGAAAGCGCGGCCU-AGC G-AACGCUCA------------------------UG---------C-CCCC-ACA-CGU- ----------------------------GGGGGCUGGGCAUGA-CAG--AAAAGUUACCC CGGGGA-UAACAGGGUCGUCGCGGGCGAGAGCUCCCAUCGACCCCGCGGUUUGCUACAUC GAUGUCGGCUCUUCCCACCCUGGAGGUGCAGCUGCCUCCAAGGGUAGGGCUGCCCGCCCG UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGCGAGACAGGUCGGACUCUAAGGGUGA --GGG--G-UGC------------------------------------------------ -----ACGCCGC-CUGAGGGGAAG-GUACUCCUAGUACGAGAGGAACAGGGUAUCGGGGC CUC-UAGUUUG-CCGGU-UGUCC-GAUA-GGGC-AG--CGCCGGGCAGCCA-C-GCCCUA -GG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CUC-CCCGAAA--- --AGAGGCG---------------------------GC--GG---------UG-U----- A--UUG-G-CC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---GCAGCA-UGCG--G-G---AGCCC---UCCC--C-AAGAACAGGG-GG-UUGAUGGG GUGGG-GGUGUAAG-CCU-CGAGGG----C---------------GAAA--G--UCC--G -AGGGGU--U--CAGCC-----UGCC----A-CUCCCAA-UCGGGC-GA--G--U-CCAG -CG--C-- >Methanocaldococcus_jannaschii -------------------AGCCCACCU-GGUGGAUG-GCU-CGGCU-CGGGG--CGC-C GAGGAAGGGCGUGGC-AAGCUGCGAUAAGCCCGGGGGAGGCGCAGG-CA-GCCGUG-GAA CCCGGGAUCCCCGAAUGGGACU-UCCU--------------------------------- -------------GCCC------------------------------------------- ----------------------------------------CA-------------UUU-G GGGCGCUCCC-------------------------------GU----------------- -----------------UAG-GGAGCGGGA-ACGCGGGGAAAAGAAGCAUCCGAGUACCC --GCAGGAAAAGAAACCAACA-GGGAUGCCGGGAGU-AGG-GGCGACCGAAACCGG-CAC AGGGCAAA-CCGAAUCCCUAUCC--GU----AAGGGUAGG--GAGAUGUGGAGUUG---- ----------------------------CAGGGCC----CCC-----------AA----- ------UAUAGAC-----CCCC-----A----C-UGGGAAG------CCG-AAGUC-CCC UG-GA-------AUGGG------G-CGCC-AUAGAGGGUGAAAGCCCCGUAGGCGUAACC -A-GUU-GG---------GGG----UCUGG---GGUGUCCCUGAGUACCGCGCGUU---G GAUAUCGCGCGGGAAGCUGGGAGACAUUAGGCUUCCAACCCUAAAUACGU--CC-CGAGA CCGAUAGC-GAACUA-GUACCGUGAGGGAAAGCUGAAA-AGCAC-CCCUU-GCGGGGGGU GAAA-AGAGCCUGAAACCAGGUGGGUA-CGG-AAUGG-CACGGCCCGAAAGG--UAACCA CCCCGAA-----------------------------------GGAAACUCC--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGGAGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG---UGGCAUGCCGGGGUCGUGCCGUCCGUUUCGAAAAACGGGCCGG GGAGUGUA-C----GGGUGUGGCGA---GCCUAA-GGG--G-U---------UCA----- -------ACCCC-G-G-A-GGCGUAGGGAA-ACCGACA--------UGCCCGC----AAC CC------UUAU-----GGGU-G----AGGGG-CGG---------------------GGU CU----------------------------------------UAAU-------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACACCCGUAC-GACCCGAAACCGG-GCGAUC UAGGCCGGGGUAGGGUGAAGCCCCU-CGCCAGA-GGGGUGGAGGCCCGC--AGGG-GUGU UACCGCGCAAAGUGCUCCUCUGACCCCGGUCUAGGGGUGAAAAGCCAAUCGAGCCCGG-A GAUAGCUGGUUCCCCCCGAAAUAACUCGCAGGUUAGCCGGGGG-U--------------- ------------------------------------------------------------ -------------------UAGGU-AG-AUGGCGGGGUAGAGCCACGGAUAGGG--UG-U UUAGG-GGG-C-GAGA--GCCCUC-GGCA-CCCUGUCAAACUCCGAACCCGUC-AU--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-----AG--C-CCCCG-AGU-GAG-GGC--AU-ACGGG-UAAGCCGUAU-GU -CCGAGA-GGGGA----ACA--ACCCGGACCCG--GGUUAAG--GCCCC--UAAGUG--C C-G-GC-U-AAG--UGUAA-AUGA---G--AAGGGAGUCCCUGGCCUAAGACAGCGGGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUGCGUAACAGCUCACCCGUC-----G AGGUCAGGGGCCCCGAAGAUA-ACGGGGGCU--A-AGCCG---GCC--------GCC--G AGA-CCCGGGG--G-G---G--C----U-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- ---------------------------------AG-C-CAU-CC-GG--UAGGG----GG ---G-CGUC-CCGC-GGG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------AGA AGCUC-G--G-CCGU-GA-GGU--CGGG-U-GGA-CCCCGU-G--GGAACGAGAAUCC-C GGCAG-UAGUA-ACAGC-A-AA-GUGGG-G------------------UGAGAAU----- ----------CCCCAC-CGCC-GAA-GGGGC-CAGGUUUCCA-CAGCAACGGUCGUCAGC UGUGGG------------UUAGCCGG-UC-C-UAA----CCCC-C-GGGGUAA-UUCCCU G--------------------------G-G-G---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AA-GGGA-AGC-GGG--U UAA----UAUU-CCC----GCGCC-A-CC-G--GGGU-A-C--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AGGCC-AGC-UCC-UG-AC--GCUU-C GGGGUA--GG--C-CGACC-A-CCC--C-----CGUC------G---GG-GUGG--CC-- -A------AGC------GC-A------U------A--------A---G-----C--CCGG G-G------A---GU-G--C--C-----G--UAA-U-GGC-GAGAA-CC--GG----G-C -A--A--AAGC-G--U--G-A--U-GG-G-CCC-UCC----------------------- ---------GU-UA--------------------------------GG-AGG--GUU--- CG-G----CU-GAGCC-C-UG-G-AGCC-CGUGAAA-A-G-GGAG---C--U-GGC-AA- ------------------------------------------------------------ -G--GAUC-CCC--GG-U-GACCGUACCCAGAACCGACACAGGUGCCCCUAGG-CGAGUA -U-CCUAAGG-CGUGU-CGGGA-GAAUCCG-GCCCAGGGAAGUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-GC--G-GU-CUUCUC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U AA-GU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------G----- A-----GGG-G-A--C-CGCAG-GUCGCAGUGGCCAGGGGGGUCCGA-----CUGUUUAA UAAAAACACAGGUCUUGGC-UAGCCC--GU---A-A------------GGGUGU-GU-AC CAAGGCCG-ACGCCUGCCCAGUGC-C-GGUACGUGAAA-CCCGGG------------UAC A--------------ACCGGG-CGAAGCGCCG-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCAUGAAUGGCGUAACG AG-A--CCCCC--ACUGUCCCGG-GC-CGG-AACCCGGUGAACCUACCAU-UCCGGUGCA AAGGCCGGAGACCCCCAGUGGGAAGCGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GUUGGGGCAUGGCCGUGGGUGCACAGCGU-AGGUGGGAG-CCGU--C-GAA--GCC--AC CCC--------------------------------------------------------- ----------------------------------UCCG--GGGGU--GGUGGAGG--CG- CCCA-UGGGACA-CCACCCACCCAUG-GCCAUGUCCCUAA-CCC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GUAAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GGGGA -CAC-CGGCAGGUGGGCAGUUUGGCUGGGGCGGCACCCCCCUGA-AAAGGCAUC-AGGGG GGCCCAAAGGUCGGCUCAGGCGGGUCAGAACUCCGCCGUG-GAGUGC-AAGGGCAAAA-G CCGGCCUGACUU-GGUCGGUAAAAGA-GG-CCGACCAAGAGGCGAAAGCCGGGCCU-AGC G-AACCCCUG------------------------UG---------C-CUCA--CC-GAU- ----------------------------GGGGGCCAGGGAUAA-CAG--AAAAGCUACCC CGGGGA-UAACAGAGUUGUCGCGGGCAAGAGCCCAUAUCGACCCCGCGGCUUGCUACAUC GAUGUCGGUUCUUCCCAUCCUGGGCCUGCAGCAGGGCCCAAGGGUGGGGCUGUUCGCCCA UUAAAGGGGAUCGUGAGCUGGGUUUAAACCGUCGUGAGACAGGUUGGUUGCUAUCUGCUG --GGG--G-UGU------------------------------------------------ -----UGGCCGC-CUGAGGGGAAG-GUGGCUCUAGUACGAGAGGAACGAGCCGCCGGCGC CUC-UGGUCUA-CCGGU-UGUCC-GACA-GGGC-AU--UGCCGGGCAGCUA-C-GCGCUA -AG-GGAUAAGGGCUGAAGGCAUC--U-AAGCCCGAAACC------CUC-CCCGAAA--- --AUAGGCG---------------------------GC--CAG--------UC-C--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUCG----------------------------- ----------GGGA--C-G---AGGGC---UCUC--C-UAUAAGAGGA-GG-UUGAUAGG CCGGG-GGUGUAAG-CGC-CGAGG----GC---------------UUU---GC--CC--G -AGGCGU--U--CAGCC-----CGCC----G-GUACUAA-UCGCCC-AA--GG-G-CCCG -GCAG--- >Methanococcoides_burtonii -------ACUCUGGUAAUUAUGCCGUCA-GGUGGAUG-GCU-CGGCU-CAA-G--CGC-U GAUGAAGGACGUGCC-AAGCUGCGAUAAGCUCAGGGUAGGUGCAUG-GA-ACCUAU-GAA CCUGAGAUUUCCUAAUGAGACC-UCUU--------------------------------- -------------AGCA------------------------------------------- ----------------------------------------CA-------------UUU-G UGCUGAUCAG-------------------------------------------------- -----------------UAA-UGAUCGGGA-ACGCCCCGAAUUGAAACAUCUUAGUAGGG --GCAGGAAGAGAAAUCGAA--GAGAUGCCGUUAGU-AAU-GGCGAAUGAACACGG-CAC AGUUCAAA-CUGAAUCCCUCCA---GU----AAUGUGAGG--GAGAUGUGGUGUUA---- ----------------------------UAGGACUUUC----------------U----- ------AAGAUUC-----CUAU--CUU-------UUCUUAG------CUG-AACUU-UUC UG-GA-------ACGUU------A-GACC-AUAGAGUGUGAUAGUCACGUAAGCAAUGAA -A-AGA-GG---------AAU----UG-GA---AAUGUUCCUGAGUAUCGUGUGUU---G GAAAUCACGCGAGAAUUUGGGAGGCACC-AACUUCCAAAACUAAAUACGU--CU-UGAGA CCGAUAGC-GAAAUA-GUAGGGUGACCGAAAACUGAAA-AGUAC-CCCCAAAAGGGAGGU UAAA-AGUGCCUGAAACCUGAUGGUGA-UGG-AGCGA-UAUGGCAUGAAAGGA-UCUUUA GUUCGAA-----------------------------------GGAAUCAAC--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGUUGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGUUC-UAAUG----CCGAUGUCAUAUCAUACGUUUUGAAGAACGGGCCAG GGAGUGUA-A----CUAAGUGGCGAU--GGCUAA-CCU--U----------UUAUC---- ---------UGG-G-A-A-GCCGAAGCGAAA-GCAACA--------UGCGUGC----AAC -CU-----UUAC----GG-GU-G----AGACG-CGG---------------------CGU AU----------------------------------------ACAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCACUAAGUUAC-GACCCGAAGCCGG-GUGAUC UAGGCGUGGGCAGGUUGAAGCGUGG-CGAAAGC-UACGUGGAGGACCGCA-AGCG-GUAU UGAUCUGCAAAUCAUUCGUGUGACCUGCGUCUCGGAGUGAAAGGCUAAUCUAACCCGG-C AUCAGCUGGUUCCUUCCGAAACAUGUCGUAGCAUGACCUAACU-G--------------- ------------------------------------------------------------ -------------------GAGAU-AG-UCGGUGGAGUAGAGC-ACUGAUUGAU-GGC-C CU-GG-GGA-A-GAAA--UUCCUC-AUCC-GUCUGUCAAACUCCGAACCCACC-GU--C- G-U--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AA--G-GUUGGAGUC-CGG-ACU--AC-UGGGG-UAAGCCUGUA-GU -CCGUAA-GGGAG----ACA--ACCCAGCCCGU--GGUUAAG--GUCCC--UAAGUG--U C-G-AC-U-AAG--UGUUA-AUACU--A--AAGGGCGUCCCAAGCCCUAGACAGCUGGAA GGUUAGCUUAG-AAGCAGCUAU-CCUUUAAAGAGUGCGUAACAGCCCACCAGUC-----G AGGUUUGGGGCCCCGAAAAUG-GACGGGGCUC-A-AGUCG---ACC--------ACC--G AUA-CCACGGA--G-U---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ---------------------------------GG-U-AAU-CU-CG--UAGGA----AG ---G-CGUU-GCGUU-UG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------AGA AGCAG-G--G-CUGU-GA-AGU--CCUG-U-GGA-CCGAGC-G--GAAACGAAAAUCC-U GGUAA-UAGUA-GCAGC--AUA-GUUAG-G------------------UGAGAAU----- ----------CCUAAC-CGCC-GAA-GGGGC-UAGGUUUCCU-CGGCAAUGAUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GUUG-U-ACCGUAA-UUCGAG U--------------------------A-C-A---------------------------- ------------------------------------------------------------ ----------------------------------UC---AA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACU-A-UU-C--AACA----------------------- ----------------------------------------------------------AU AAAA-------------------------------------------------------- ---------------------------------------------C-UG-AC--GUUU-U GGGGCA--GG--C-UGAGC-G-GCG--C------UGUC-----G---CG-CCGUU-UA-- -A-------GC------AU-C------U------A--------A---A-----U--CUGU G-G------A---GA-G--C--C-----G--UAA-U-GGC-GAGAA-GC--AG----A-C -G--A--AUAU-G--U--U-A--U-GA-C------------------------------- ---------GA-AA----------------------------------------GU---- CG-G----CU-GCACC-C-CG-G-AACC-CGUGAAA-A-G-GG----------------- ------------------------------------------------------------ -------A-GUU--GA-AUAUCCGUACCGAGAUCUGACACAGGUGCCCCUAGC-UGAAAA -G-GCUAAGG-CGUGU-CGG-AAUAAUUUG-GCUAAGGGAAUUCGGCAAAU-UGGCUCCG UAACUUCGGG-AGAAGGAGUGC-CU-GC--C-GU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AA-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------A--C-GGCAG-GUCGCAGUGACCAGGGAACUCUAA-----CUGUCUAA UAUCAACAUAGGAGAUCGC-AAACCC--GU---A-A------------GGGCUA-GU-AC GAUCUCUG-AAUCCUGCUCAGUGC-A-GGUACCUGAAA-CUUCGG------------UUC A--------------ACGGAA-UGAAGGGCCU-G-UAAACAG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUCAAUG AG-A--GUUCU--ACUGUCCCUA-GC-CAG-AGUCCGGUGAAGCUUACAU-UCUAGUGCA GAGUCUAGAGACCUCUAGGGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GCUGGGUUGUGAUUUUGGAUGUACAGUGU-AGGUAGGAG-ACGU--C-GAA--GCC--GG UGC--------------------------------------------------------- ----------------------------------GCCA--GCAUC--GGUGGAGU--CG- CAAU-UGGGACA-CUACCCUUCCAAA-GUUACGACCCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GUGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGGA -CCC-CGAUAGGUGGGCAGUUUGCCUGGGGCGGGACGCCCUUGA-AAAGAUAUC-AAGGG CGCGCAAUGGUUAACUCAAGUGGGUCGGAAACCUACUGAA-GAGUGC-AAGAGCAUAA-G UUAGCCUGACGU-GAUUCAGCACA--GUAGUGGAUCACGAGACGAAAGUCGGUUCU-AGC G-AACCUUUA------------------------UG---------C-CCGC--UU-GGU- ----------------------------GCGGGCUAAAGAUGA-CAG--AAAAGUUACCC CGGGGA-UAAUUGAGUCGUUGCCGGCAAGAGCACAUAUCGACCCGGCAGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCUGUGCAGCAGCAGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUACUA --GAG--G-UGU------------------------------------------------ -----AUGUGGU-CUGAGGGUAAG-UUGCUUUUAGUACGAGAGGAACAGAGCAACGGCGC CAC-UGGUCGA-UCGGU-UGUCU-GACA-AGGC-AC--UGCCGAGCAGCUA-C-GCGCUA -AG-GAAUAAGAGCUGAAUGCAUC--U-AAGCUCGAAAUC------UAA-CCUAAAA--- --AGAGACC---------------------------AC--U------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------A---AGGGU---UCCG--G-UAAAAGACCG-GA-UCGAUAGG AAUGG-GAUGUAAG-CAC-CAAG----------------------GCAA-------C--G -AGGUGU--U--CAGUC-----CGCA----U-UUACUAA--UAUCCGUG-----C-CUC- -------- >Methanococcus_aeolicus -----CCACA-UAUCUAUUACCCUAUCU-GGGGGAUG-GCU-UGGCU-UGGAA--CGC-C UAUGAAGGACGUGGU-AAGCUGCGAUAAGCUCAUGCGAGGCGCAUA-CA-GCCGUA-GAA CAUGAGAUUUCCGAAUGGGACU-UCCU--------------------------------- -------------GCUC------------------------------------------- ----------------------------------------UU-------------UUG-A GCGAUUCG---------------------------------------------------- -----------------UAA-GAAUCGGGA-ACGCGGGGGAUUGAAGCAUCUUAGUACCC --GCAGGAAGAGAAAUCAAAC-GAGAUUCCGUUAGU-AGA-GGCGAUUGAACACGG-AAC AGGGCAAA-CUGAAUCCCGC-----------AA-----GG--GAGAUGUGGUGUUA---- ----------------------------UAGGAAA----CUC-----------UU----- ------ACG-----------AC--UUAG----GAAAGGAUG------CCG-AAGUU-GUC UG-GA-------AAGGC------A-CAUC-AUAGAGGGUGAUAAUCCCGUAGGUAUAACU -G-ACC-UG---------AGU-----UUGA---GAUUUUCCUGAGUACCGUGCGUU---G GAUAUCGCGCGGGAAUUUGGGAGGCAUC-GACUUCCAACCCUAAAUACGU--UC-CAAGA CCGAUAGU-GCACUA-GUACCGUGAGGGAAAGCUGAAA-AGCAC-CCUUA-ACCGGGUGU GAAA-AGUGCCUGAAACCAGAUAGGUA-UCG-UAUGG-CAUGGCUCCAAAGG--CAACUA UUCCGAA-----------------------------------GGAAUCCAU--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUAAAAUGGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGAA-UAGAG---UCCAGAGUUGUGUCGUCCGUUUCGAAAAACGGGCCGG GGAGUAUA-U----UGUUGUGGCGA---GCCUAA-GAC--C----------UUUAU---- --------GGUC-G-G-A-GGCGUAGGGAAA-CCAACA--------AGUCCGC----AAG -C------UUUU-----G-CU-G----AGGGA-CGG---------------------GGU CU----------------------------------------UAA--------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACAGCGAUAU-GACCCGAAACCGG-GCGAUC UAGGCCAGGGCAAGGUGAAGUCCCU-CAUCAGA-GGGAUGGAGGCCUGC--AGAG-GUGC UGCCGUUCGAAGCGCUCUUCUGACCUUGGUCUAGGGGUGAAAGGCCAAUCGAGCCCGG-A GAUAGCUGGUUCCCCCCGAAGUAACCCUAAGGUUAGCCGGAGG-U--------------- ------------------------------------------------------------ -------------------UAGGU-AG-AUGGCAGGGUAGAGC-ACUGAUAGAG--GG-G UUAGG-GGA-C-GAAA--GUCCUC-GCCU-UUCUGUCAAACUCCGAACCUGUU-AU--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----UGC-----AG--C-CUCUG-AGA-AAG-GGC--AU-ACGGG-UAAGCUGUAU-GU -CCGAGA-CGGGA----AUA--GCCGCGACUCA--GGUUAAG--GUCCC--UAAGUA--C U-G-AU-U-AAG--UGUGA-ACAC---G--AAGGGCGUCCUUGGCCUAAGACAGCAGGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUAAAAGAGUGCGUAACAGCUCACCUGUC-----G AGGUCAGGGGCCCCGAAAAUG-GACGGGGCUA-A-A-UCA---GUU--------ACC--G AGA-CCUGAGG--G-C---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- ---------------------------------GG-U-GAU-CC-GG--UAGGG----GG ---G-CGUU-CUGU-AAG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------AGA AGUUU-G--G-CUGU-GA-AGU--CAAA-U-GGA-CCUUGU-A--GAAAUGAAGAUCC-C GGUAG-UAGUA-ACAGC-ACAA-GUGGA-G------------------UGAGAAU----- ----------CUCCAC-CGCC-GAA-GGGGC-AAGGGUUUCA-CAGCAAUGUUCGUCAGC UGUGAG------------UAAGCCGG-UC-C-UAA----CUUC-C-GAGGUAA-CUCCUU U--------------------------G-G-A---------------------------- ------------------------------------------------------------ ----------------------------------AG---GA-AA-GGGA-GAC-AGG--U UAA----UAUU-CCU----GUGCC-A-UC-U--AAAU-A-C--A-C----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AGGUU-AGU-UUC-UG-AC--GCUU-C AGGGUA--UG--C-UAACU-A-CUC--U-----UGUC------U---GG-GUAG--UC-- -A------AAU------GU-A------U------A--------A---G-----U--CUGG G-G------A---GA-G--U--U-----G--UAA-U-AAC-GAGAA-CC--AG----A-U -G--A--AAGC-A--U--G-A--U-GA-U-CCA-UCC----------------------- ---------UU-UA--------------------------------GG-AUG--GUU--- UG-G----CA-GAUCU-C-UG-G-AGCC-CGUGAAA-A-G-GGAA---C--U-AUC-AU- ------------------------------------------------------------ -G--GAUU-UUA--GA-U-GACCGUACCCAGAACCGACACUGGUGCCCCUAGG-UGAGUA -U-CCUAAGG-CGUAU-CGGAU-GAAUCUA-GUCGAGGGAAGUCGGCAAAA-UGGCUCCG UAACUUCGGG-AGAAGGAGUGC-CA-GU--G-AC-CUUGUC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AG-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G--U-CGCUG-GUCGCAGUGACCAGGGAGGUCCGA-----CUGUUCAA UACAAACACAGGUCUUAGC-UAGUCU--GA---A-A------------AGAUGU-GU-AC UAAGGCCG-ACGCCUGCCCAGUGC-U-GGUACGUGAAC-CCCGGG------------UUC A--------------ACCGGG-CGAAGCGCCA-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUUCCUUGUCGGG-UAAGUUCCGACCUGCAUGAAUGGCGUAACG AG-A--CCUCC--ACUGUCCCCG-AC-UAG-AAUCCGGUGAACCUACCAU-UCCGGUGCA AAGGCCGGAGACUUCCAGUGGGAAGCGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GUUGGGGCAUGAUUGUGGGUGUACAGUGU-AGGUGGGAG-CCAU--C-GAA--ACC--UU CUC--------------------------------------------------------- ----------------------------------GCUA--GGGAA--GGUGGAGG--CG- UCCA-UGGGACA-CCACCCUCCUAUG-AUCAUGUCCCUUA-CCC-A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AGUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-GGGGA -CAC-CGGUAGGUGGGCAGUUUGGCUGGGGCGGUACCCUCCUAA-AAAUGCAUC-AGGAG GGCCCAAAGGUUGGCUCAAGCGGGUCAGGACUCCGCUGUU-GAGUGU-AAGGGCAAAA-G CCAGCCUGACUU-AGUUGUCCACAA--UACGCAACUAAGAGACGAAAGUCGGGCCU-AAC G-AACCCCUG------------------------UG---------C-CUCA--CC-GAU- ----------------------------GGAGGCCAGGGAUGA-CAG--AAAAGCUACCC CGGGGA-UAACAGAGUUGUCGCGGGCAAGAGCCCAUAUCGACCCCGCGGCUUGCUACCUC GAUGUCGGUUUUUCCCAUCCUGGAUCUGCAGCAGGAUCCAAGGGUGGGGCUGUUCGCCCA UUAAAGGGGAUCAUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUGGUUGCUAUCUGCUG --GAA--G-UGU------------------------------------------------ -----UGGCUGU-CUGAGGGAAAG-GUGGUUCUAGUACGAGAGGAACGAGCCGCCGGUGC CUC-UAGUUUA-UCGGU-UGUCC-GACA-GGGC-AU--UGCCGAGCCGCCA-C-GCACCA -AG-GGAUAAGAGCUGAAAGCAUC--U-AAGCUCGAAGUC------CAU-CCUGAAA--- --ACAGACA---------------------------GC--CGU--------CC-U--U-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CUAG----------------------------- ----------GAGG--C-G---AGGGG---UCCC--A-UAGAAGAUGG-GU-UUGAUAGG CUAGG-AAUGUAAG-CAU-CAAGG---------------------UU-UU-----CC--G -AGAUGU--U--UAGUU-----CGCU----A-GUACUAA-CCCCCC-AA--GAGA-UA-- -------- >Methanocorpusculum_labreanum --------------UUCUUAUGCCGGUU-AGUGAAUG-GUU-CGGUU-UGA-G--AGC-U GAUGAAGGGCGUGCC-AAGCAGCGAAAUGCCCCGGGAAGACGCAAG-GA-GUCUGU-GAU CCGGGGAUCCCCUAAUAGGACC-UCCC--------------------------------- -------------CACG------------------------------------------- ----------------------------------------AU-------------UUA-U CGUGAAUCCG-------------------------------------------------- -----------------UAA-GGAUGGGGA-ACCCCCCGAAGUGAAACAUCUCAGUAGGG --GGAGGAAGAGAAAUCAAUU-GAGAUUACGUUAGU-AGA-GGCGAUCGAACCCGU-AAU AGUCUAAA-CUGAAUCCCGCA----------------AGG--GACAUGUAGUGUAU---- ----------------------------GGCCUUC----GUU-----------GU----- ------AGUAUGU-------------GU----U-UAUCUAA------UGA-AAGUA-GCU UG-GA-------AUGGC------U-UACC-UUAGAGGGUGACAGUCCCGUACGUGGUGGU -A-AAC-AC---------AGC-----UUAG---AAGUGUCCUGAGUAGCGCGGGUU---G GAAUUCCCACGUGAAUAUGGGGGUCACC--ACCUCCAAGACUAAAUACUC--CU-CAAAA CCGAUAGC-GAAAUA-GUAGCGUGAGCGAAAACUGAAA-AGUAU-CCCUGAAAAGGAAAU GAAA-AGUGCCUGAAACUAACCGGUGA-UCG-UGUGU-UACGGCGUGCAAGGA-UCUUCC GAUCGAA-----------------------------------AGAACCCGU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGCGGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAUGAGAUU-GGUUG----CCGACGUCGUAACUUACGUUUUGAAGAACGGGCCAA AGAGUGUA-U----UCCGCUGGCGA---GGUUAA-CC---G-----------GAA----- ----------GG-G-C-A-GCCGCAGCGAAA-GCGACA--------AGCGCGU----AG- ---------UUU-------AC-C----UGGCG-CGG---------------------CGU ACU---------------------------------------AAUA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCAACGGGAUAC-GACCUGAAACCUG-GUGAUC UAUGCCUGAGCAGGUUGAAGCGUGC-CGAAAGG-UGCGUGGAGGACCGCA-UGCG-GUAU UGAUAUGCAAAUCAUUCGCGUGACUUGGGUAUAGGAGUGAAAGAUUCAUCGAACCGGG-U GUCAGCUGGUUCCUCUCGAAACAUGUCUAAGCAUGACCUCGAC-C--------------- ------------------------------------------------------------ -------------------GAGAA-UG-AUAGUGAGGUAGAGC-ACCUAUUGGA-AAU-C CC-GG-GGA-A-GAAA--UUCCUC-GCUU-UCCUGUAAAACUCCAAACUCCCU-AU--C- U-U--------------------------------------------------------- ------------------------------------------------------------ -----UGU-AG--AC--G-UCGGGCAGU-CCG-GGC--UA-CGGGG-UAAGCUUGUA-GU -CCGUAA-GGGAG----ACA--ACCCAGACCAU--GGUUAAU--GCCCC--CCAAUG--U A-G-GC-U-AAG--UGUCA-ACACU--G--AAUGAAGUCCUAGGUCAAAGACAACUGGAA GGUGAGCUCAG-AAGCAGCUAU-CCUUUAAAAAGUGCGUAACAGCUUACCAGUC-----A AGAUUUAGGGCGCAGAAAAUG-GACGGGGCUC-A-AGCCU---ACU--------GCA--G AUA-CCAUGGC--GCA---C--G----UU------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUG----------------------------- --------------------------------AAC-G-UGAUCG-AG--UAGAG----AG ---G-CGUC-CUGUA-UG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------UGA AGCAG-G--G-GUGU-AA-GUU--CCUG-U-GGA-CCGUAU-A--GGAAUGAGAAUUU-U GGCAG-UAGUA-GAAGC--AAA-GAAUG-G------------------UGAGAAU----- ----------CCAUUC-CGCC-GAA-GGGGC-UAGGUUUCCU-CGGCAAUGUUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GCUG-C-AUCAUAA-GUUGCA U--------------------------G-C-A---------------------------- ------------------------------------------------------------ ----------------------------------GC---AA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-G-GC-G--UUA------------------------ ----------------------------------------------------------AU -AU--------------------------------------------------------- --------------------------------------------AC-UG-AC--GCAU-C GGGUUA--UG--C-AUAGC-G-GGA--C------CGUC-----G---UC-CCGU--CC-- -A------AUC------GU-A------U------A--------A---A-----C--UCUU G-G------A---GU-A--C--C-----G--UAA-U-GGU-GAGAA-UU--GA----G-U -G--A--AAGC-G--U--G----A-UG-G-C----------------------------- ---------GU-AA----------------------------------------GU---- GU-G----UA-AACAC-C-UG-G-UGCC-CGUGAAA-A-G-GU----------------- ------------------------------------------------------------ -----AA--CGC--AA-U-GUCCGUACCGAGAACCGACACAGGUGCCCCUAGU-UGAAAA -G-ACUCAGG-CGUGU-CGGAAUUAUUUGU-GGUAAGGGAACUCGGCAAAA-UGGCUCCG UACCUUCGGA-ACAAGGAGUGC-CU-GC--C-UA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G UG-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------U--A-GGCAG-GUCGCAGUGACCAGGGAGCUCUAA-----CUGUCUAA CAACAACAUAGCAGACUGC-AACUCC--GU---A-A------------GGACUA-GU-AU AGUCUGUG-AAUCCUGCCCAGUGC-G-GGUAUCUGAAC-ACUGAU------------UAC A--------------AUCGGA-CGAAGGACCC-G-UAAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUUAAUA AG-G--GCUCU--ACUGUCCCUA-CC-GCA-AAUCCGUUGAACCUUUUAU-CCUUGUGCA GAGGCAAGGGACUCCCAUCGGGAAGUGAAGA-CCCCAUGGAGC-UUUACUGCAGCCUGUC GUUGACUUACGGUAUUACAUGCGCAGCGU-AGAUAGUAG-GUGU--U-AAU--GCU--CA UAU--------------------------------------------------------- ----------------------------------UCCG--GUAUG--AGUGGAGC--CA- CAGU-UGAGACA-CUAUCCUUGUUCU-GCUGUAAUUCUCA-CUC---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------UUU--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------G---AGGA -CAU-CGGUAGGUAGGCAGUUUGGGUGGGGCGCCACACCCUCGA-AAAAAUAUC-AAGGG UGCCCUAUGGUCAACUCAUGUGAGUCAGCAACUCACAGGA-GAGUGUCAAGAGCAUAA-G UUGGCUUGACGU-GAUUUCGCAUAGC-A-AGAAAUCACGAGUGGAAACACGGGUCU-AAC G-AACCAAUA------------------------CG---------C-CUUU--UU-GGU- ----------------------------GAGGGCUAUUGACUA-CAG--AAAAGCUACCC UGGGGA-UAACAGAGUCGUCGCCGGCAAGAGCACAUAUCGACCCGGCGGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCUGUGCAGCAGCAGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGGGAUCGUGAGCUGGGUUCAGACCGUCGUGAGACAGGUCGGUUACUAUCUGAUG --GGA--G-UGU------------------------------------------------ -----UCGAAAU-CUGAGAGCAAG-AAUGAAAUAGUACGAGAGGAACUUUCAUUCGUCAC CUC-UGGUGUA-UCGGU-UGUCU-GAUA-AGGC-AG--UGCCGAGCAGCUA-C-GUGGCA -CG-AGAUAAAAACUGAAAGCAUC--U-AAGUUUGAAACU------UCG-CUUGAAA--- --AGAGAUU---------------------------UC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- ------------------U---AGAGC---ACCG--G-UAAAAGACCG-GG-UUAAUAGG CUUGG-GAUGUACG-CAC-GAAG----------------------GUAA-------C--G -ACGUGU--U--UAGUC-----CGCA----A-GUACUAA-C-GCUC-AA----------- -------- >Methanoculleus_marisnigri ------------------UAUGCCUAUC-AGUGGAUG-GCU-CGGUU-CGA-G--UGC-C GAAGAAGGGCGUGCC-AAGCUGCGAUAAGCUCCGGGAAGACGCAUG-GA-GUCUAC-GAU CCGGAGAUUCCCUAAUGAGACU-UCUU--------------------------------- -------------AACA------------------------------------------- ----------------------------------------CU-------------UCG-G UGUUGAUCCG-------------------------------------------------- -----------------UAA-GGAUCGGGA-ACCCCCCGAAUUGAAACAUCUUAGUAGGG --GGAGGAAAAGAAAUCAACC-GAGAUGUCGUUAGU-AGA-GGCGAUCGAACACGA-CAG AGUUCAAA-CUGAAUCCCGCA----------------AGG--GAGAUGUGGUGUAG---- ----------------------------UAAGCCU----ACC-----------AU----- ------CUGGAUG-------------CC----AAGGUCAAA------CGG-AAAUC-CUC UG-GA-------AUGAG------G-UGCC-AAAGAGGGUGAUAGCCCCGUACGUGCAAGC -U-GAG-GU---------GUC-----CUGG---UAGUGUCUUGAGUACCGCGGGUC---G GAAUUCUCGCGGGAAUCUGGGGGUCAUC-AACCUCCAAAACUAAAUACUA--CU-CGAAA CCGAUAGC-GUAUUA-GUAGCGUGAGCGAAGGCUGAAA-AGUAA-CCCUUGAAAGGUGGU UAAA-AGCGCCUGAAACUGAUAGGUGA-UAG-UGAGU-UACGGCGCGAAAGGA-UCUUCC ACGUGAA-----------------------------------GGAACCCGU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGCGGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGGGCG----UGGU-UGCCGGUGUCGUAACGUACGUUUUGAAGAACGGGCCAG AGAGUUUA-U----UCUGUAGGCGAA--GGUUAA-CC---C-A---------AAA----- ----------GG-G-G-A-GCCGAAGGGAA-ACCAACA--------GGUCCGU----AGC -C-------UUC-----GGGC-A----UGGGA-CGG---------------------CGU AUU---------------------------------------AAAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCUGCAGGAUAA-GACCCGAAGCCUA-GCGAUC UAUGCGUGGGCAGGUUGAAGCGUGC-CGAAAGG-CGCGUGGAGGACCGCA-AGCG-GUUU UGAUAUGCAAAUCAUUCGUGUGACCUGCGUAUAGGAGUGAAAGAUUAAUCGAGCUGGG-C AUCCGCUGGUUCCUCUCGAAACAUGCCGUAGCAUGACCUGGCU-G--------------- ------------------------------------------------------------ -------------------GAGAU-AG-ACGGUGAGGUAGAGC-ACUGAUUGGG-GGA-G CU-GG-GGG-A-GAAA--UCCCUC-ACCC-UCCUGUCAAACUCCAAAUUCCCC-GU--C- G-U--------------------------------------------------------- ------------------------------------------------------------ -----CGA-AG--AA--G-GCUGGCAGU-CCG-GAC--UA-CGGGG-UAAGCUUGUA-GU -CCGUAA-GGGAG----ACA--ACCCAGACCGU--GGUUAAU--GUCCC--UCAAUG--U A-G-GC-U-AAG--UGUCA-ACACU--G--AAAGGCGUCCCAGGCCAAAGACAACUGGAA GGUGAGCUCAG-AAGCAGCUAU-CCUUUAAAAAGUGCGUAACAGCUUACCAGUC-----G AGGUUUGGGGCACUGAAAAUG-GACGGGGCUA-A-AGCCU---ACU--------ACA--G AUA-CCACGGA--C-C---A--C----A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------CUUUC----------------------------- --------------------------------GUG-U-GAU-GG-CG--UAGAG----AG ---G-CGUG-CUGCC-UG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------AGA AGCAG-G--G-GCGU-GA-GCU--CCUG-U-GGA-CCGGGU-A--GUAUUGAGAAUUC-U GGCAU-UAGUA-GAAGC--AAA-GUUGG-G------------------UGAGAAU----- ----------CCCAAC-CGCC-GGA-GGGGC-UAGGUUUCCU-CGGCAAUGUUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GAUG-U-GUCGUAA-UUCGAG C--------------------------A-C-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---AA-CA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-A-UU-C--A-------------------------- ---------------------------------------------------------UCC GUAGC------------------------------------------------------- ---------------------------------AGUUUACUG-CCC-UG-AC--GCUU-C GGGAUA--UG--C-CGGGC-A-GGG--U------CGUC-----G---CC-CUGU--CC-- -A------AGC------GU-U------C------A--------A---G-----C--UCGU G-G------A---GU-A--C--C-----G--CCA-U-GGU-GAGAA-GC--GA----G-U -G--A--AGGC-G--U--G----A-UG-G-A----------------------------- ---------GU-AA----------------------------------------UU---- CG-G----CA-AAUUC-C-UG-G-AGCC-CGUGAAA-A-G-GG----------------- ------------------------------------------------------------ -------G-GAU--GA-AUGUCCGUACCGAGAUCUGACACAGGUGCCCCUAGC-UGAAAA -G-GCUAAGG-CGUGU-CGGUU-UAAUCGU-GUUAAGGGAACUCGGCAAAU-UGGCCCCG UAACUUUGGG-AUAAGGGGUGC-CU-GC--C-UG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------C--A-GGCAG-GUCGCAGUGACCAGGGGGCUCUGA-----CUGUCUAA UAACAACAUAGGUGACUGC-AACUCG--GA---A-A------------CGACUA-GU-AU AGUCACUG-AUUCCUGCCCAGUGC-G-AGUAUCUGAAC-ACCGGG------------UUC A--------------ACCGGA-CGAAGGACUC-G-UAAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUUAACG AG-A--GCCCU--ACUGUCCCUA-AC-ACG-AAGCCGUUGAACAUUUUAU-CCUAGUGCA GAGACUAGGGACUCCAGAUGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GCUGUGUUACGGUAUUCCUUGCGCAGCGU-AGAUGGGAG-GCGU--C-GAU--CCA--CC CCU--------------------------------------------------------- ----------------------------------UCCG--GGGGG--UGGGGAGC--CA- ACAA-UGAGACA-CCAUCCUUGGUUU-ACUGUAACACUAA-CUC-A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AAC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CU-GAGGA -CAA-CGAUAGGUAGGCAGUUUGGGUGGGGCGCCACACCCUCGA-AAAAAUAUC-AAGGG UGCCCUAUGGUCAACUCAUGUGAGUCAGAAACUCACAGGA-GAGUGUCAAGAGCAUAA-G UUGGCCUGACGC-GAUUUCGCAUAGC-A-AGAAAUCGCGAGAGGAAACUCGGGUCU-AAC G-AACCAAUG------------------------AG---------C-CUUA--UU-GAU- ----------------------------GAGGGCCAUUGACGA-CAG--AAAAGCUACCC CGGGGA-UAACAGAGUCGUCGCCGGCAAGAGCACAUAUCGACCCGGCGGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCCGUGCAGCAGCGGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGGGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUAUCU --GGA--G-UGU------------------------------------------------ -----AAGGAGU-CUGAAGGUAAG-AUGGAAAUAGUACGAGAGGAACUUUCCGUCGUCGC CUC-UGGUCGA-UCGGU-UGUCC-GACA-GGGC-AG--UGCCGAGCAGCUA-C-GCGAUA -AG-GGAUAAAAGCUGAAAGCAUC--U-AAGCUUGAAACC------UGA-CCCGAAA--- --AGAGACU---------------------------CC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------G---AGGAC---ACGG--G-UAAAAGACCC-GC-UUGAUAGG UCCGG-GAUGUAAG-CAC-GAAG----------------------GCAA-------C--G -ACGUGU--U--CAGUC-----CGCG----G-AUACUAA-C-GUC--------------- -------- >Methanopyrus_kandleri --------CG-GGUCGGCUAAGCCGUCG-GGUGGAUG-CCU-UGGCU-CGG-G--CGC-C GAGGAAGGCCGUGGC-AAGCUGCGAUAAGCCCGGGCGAGGCGCAUG-CA-GCCGUG-GAA CCCGGGAUCGCCGAAUGGGACC-UCUC--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------GG-------------GCC-G AAAGGUCCCGGCACUCCGGGGGGAAACCCCGGGCCCUCGUGGCCCGGGGGAGU------- --------------ACCCCC-GGAGGGGGA-ACCCGCCGAACUGAAACAUCUUAGUAGGC --GGAGGAAAAGAAAGCAACACGCGAUGCCGUGAGU-AGG-GGCGACCGAAAACGG-CAG AGGGCAAA-CUGAACACCCGCCC--GA----AAGGGCGGG--UGGAUGUGGGGUUG---- ----------------------------CAGGCCCGGGCCGC-----------CU----- ------AUGUGGC-----CGUC--UCCC----CCGGAACGG------CCG-AAGUG-CCC UG-GA-------ACGGG------C-CGCC-GGAGAGGGUGACAGCCCCGUAGGCCGCCGG -G-GGA-CG---------GCC----GCUGG---CCCGGGCCUGAGUACCGUCGGUU---G GAUAUCCGGCGGGAAUCUGGGGGACAUC-GGCCCCCAACCCUAAAUACGU--CC-CGAGU CCGAUAGC-GAACAA-GUACCGUGAGGGAAAGGUGAAA-AGAAC-CCCGG-AAGGGGAGU GAAA-AGAGCCUGAAACCCGACGGCGA-UAG-UCUGC-CGGGGCCCGCAAGGGAUGAAGC CCCCCGAA----------------------------------GGAAACCCC--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUGACGGGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG-GGCCG---ACCGGGGUCCCGGCGUUCGUUUUGAAACACGAGGCGG GGAGUCCG-C----GGCCGCGGCGA---GUCUAA-GGG--G----------UUCAAA--- --------CCCC-G-A-A-GGCGUAGGGAA-ACCGACA--------CGCCCGC----AGC CCGGCC--GUUA-GGCCGGGC-C----AGGGG-CGG---------------------GGU CCU---------------------------------------AAU--------------- -------------------------------------------A-GGGCC---------- ----------------------------------------CG------------------ ------------------------CAGCCGCGGCCGCGG-GACCCGAAACCGG-CCGAUC UAGCCCGGGGCAGGGUGAAGCGGCC-CUAAAGG-GCCGUGGAGGCCCGCU-AGGG-GUGC UGUAGUGCAAAACGCUCCCGUGACCCCGGGCUAGGGGUGAAAGGCCAAUCGAGGCCGG-A GACAGCUGGUUCCCCCCGAAACGGCCCGCAGGUCGGCCCGGCC-G--------------- ------------------------------------------------------------ -------------------GAGGU-AG-GUGGCGGGGUAGAGC-ACUGAUUCCC-CGG-U UA-GG-GGC-C-GAGA--GGCCCC-GCCG-GGGAGUCAAACUCCGAACCCGCC-AC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AA--G-GCCGG-AGUUGGG-GCC--GG-CGG-G-UAA-GCCGCC-GG UCUGAGA-GGGGA----AUA--ACCCAGACCGG--GGUUAAG--GCCCC--AAAGUG--C C-G-GC-U-AAG--UGUUAA-AUAG--A--AAGGGAGUCCCCGGCCGAAGACAGCGGGGA GGUAGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUGCGUAACAGCUCACCCGUC-----G AGGUCGGGGGCCCCGAAAAUG-GACGGGGCUG-A-AGCCG---GCC--------GCC--G AGA-CCCCGGG--GCC---G--C----GG-G---------------CC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAU------------------------------ ----------------G----G---------CCCG-C-GGG-CC-GG--UAGGG----GG ---G-CGCC-CCGG-CG-------------------GC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGCCG-G--G-CCGU-GA-GGU--CCGG-U-GGA-GCCGUC-G--GGGACGAGAAUCC-C GCCGG-UAGUA-GCAGC-A-AA-GCGGG-G------------------UGAGAAU----- ----------CCCCGC-CGCC-GGA-GGGGC-CAGGGUUCCU-CGGCAAUGUUCGUCAGC CGAGGG------------UAAGUCGG-CC-C-UAA----GGCC-G-GCGGUAA-CACCGA C--------------------------C-G-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUACC-G-CG-G--GGGU-A-C--GC-----C--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGGGA----------------------AG-CCCGGC-GGC-CG-AC--GCCU-C GGGGUA--GG--CCGGGCG-G-GGC--U-----GUC-------G---CC-CCGU--CC-- -A------ACC------GG-U------G------A--------A---G-----G--CCGG G-G------A---GU-C--C--C-----G--UAA-U-GGG-GAGAA-CC--GG----C-C -G--A--AGCC-G--G--G-A--A-GG-G-CCG-CCC----------------------- ---------GUUAU--------------------------------GG-GCG--GUC--- CG-G----CC-GAUCC-C-CG-G-GGCC-CGUGAAA-A-G-GCCG---C--C-GGG-AA- ------------------------------------------------------------ -G--GAUC-CCC--CG-C-GACCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAGAA -G-CCUAAGG-CGCGG-CGGGG-UAACCCG-GCCGAGGGAAAUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CC-GC--G-GC-CCUGACC-CC-GA-GGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U CG-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------A-CCU---CGG-G-G----- G-----AGG-G-G--C-CGCGG-GUCGCAGUGACUAGGGGGGGCCGA-----CUGUUUAA UAAAAACAUAGGUCCCGGC-UAGCCC--GA---A-A------------GGGCUG-GU-AC CGGGGCCG-ACGCCUGCCCAGUGC-C-GGUACGUGAAG-CCCGGG------------UAC A--------------ACCGGG-UGAAGCGCCG-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUGCCUUGCCGGU-UAAGUACCGGCUUGCAUGAAUGGCGUAACG AG-C--CCCCC--ACUGUCCCCG-GC-CGG-GACCCGGUGAACCCGCCAU-CCCCGUGCA GAGGCGGGGGACCCCCGGCGGGAAGCGAAGA-CCCCGUGGAGC-UUUACCGCAGCCUGCC GUUGGGGCACGGCUGCGGGUGUAUAGCGU-AGGUGGGAG-CCGU--UACUCAGGGG--CG GCC--------------------------------------------------------- ----------------------------------GCCA--GGCCGU-CCCCGAGG--CG- CCCA-UGGAACA-CCACCCUCCCGCG-GCUGUGCCCCUAA-CCC-G--GG--------CC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-AGAA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------G-G-CCC-GGGGA -CAG-CGGUUGGUGGGCGGUUUGGCUGGGGCGGCACGCCCCCGA-GAAGGCAUC-GGGGG CGCCCAAAGGUCGGCUCAGGCGGGUCAGAAAUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACUG-GGUCCCGCACA--AUAAGGGACCCAGGCGGGAAACCGUGGCCU-AGC G-AACCCCGG------------------------UG---------C-CGCC--CC-GGU- ----------------------------GGCGGCCCGGGAUGA-CAG--AAAAGCUACCC CGGGGA-UAACAGGGUGGUCGCGGGCAAGAGCCCACAUCGACCCCGCGGCUUGCUACCUC GAUGUCGGCUCUCCCCAUCCUGGCGGUGCAGCAGCCGCCAAGGGUGGGGUUGUUCGCCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUCGCUAUCUGCCG --GGG--G-UGU------------------------------------------------ -----UGGCCGC-CUGAGGGGAAG-GACCGCCUAGUACGAGAGGAACGGCGGUCCGCGGC CUC-UGGUGGA-CCGGC-UGUCC-GGCA-GGGC-AA---GCCGGGUAGCUA-C-GCCGUA -UC-CGAUAAGGGCUGAAAGCAUC--C-AGGCCCGAAGCG------GUC-CCCGAAA--- --AUAGGCG---------------------------GC--CGU----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------U-G---AGGCC---UCGG--G-UAAAAGACCC-GG-UUGAUGGG GCGGG-GGUGUAAG-GCC-CAAGGGG--CC---------------GUUG--GGCCCC--G -AGGGCC--U--GAGCC-----CACC----G-CUCCCAA-UCGGCC-GA-----U-GGAC -CCGGC-- >Methanoregula_boonei ------------------UAAACCUACC-AGUGGAUG-GCU-CGGUU-CAA-G--UGC-C GAAGAAGGGCGUGCC-AAGCUGCGAUAAGCUCCGGGUAGACGCAAG-GA-AUCUAU-GAU CCGGAGAUGCCCUAAUAGGACA-UCCU--------------------------------- -------------GACG------------------------------------------- ----------------------------------------CU-------------UUA-U GCGUCUUUCCG------------------------------------------------- -----------------UAA-GGAAAGGGA-ACGCCCCGAAUUGAAACAUCUCAGUAGGG --GCAGGAGAAGAAAUCAACC-GAGAUGUCGUUAGU-AGA-GGCGAUCGAACACGA-CAG AGCUCAAA-CCGAAUCCCGCA----------------AGG--GAGAUGUGGUGUUA---- ----------------------------UAAGCCC----ACC-----------GU----- ------ACGAUGC-------------CG----GAUGUGAAG------CGG-AAGUU-GCC UG-GA-------AGGGC------A-CACU-ACAGAGGGUGAAAGUCCCGUACGCAGAAGC -A-GAC-GG---------UGU-----UAGG---UGGUGUCUUGAGUACCGCGGGUU---G GAAUUCUCGCGGGAAUUCAGGGGUCAUC-AACCCCUAAAGCUAAAUACAC--CU-UGAAA CCGAUAGC-GAAUUA-GUAGCGUGAGCGAAAGCUGAAA-AGUAA-CCCUGAAAAGGUGGU UAAA-AGUGCCUGAAAUUGGUAGGUGA-UCG-CGGGU-UGCGGCAUGAAAGGA-UCUUCC UUAUGAA-----------------------------------GGAACCCGU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGCGGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGGGUAA-GGUUG----CCAGUGUCGCAACGUACGUUUUGAAGAACGGGCCAG AGAGUUUA-U----UCUGUUGGCGAA--GGUUAA-CC---C-----------ACAA---- ---------GGG---G-A-GCCAUAGGGAA-ACCAACA--------AGUCCGU----AGC -A------GCAA-----U-GC-G----UGGGA-CGG---------------------CGU AU----------------------------------------UAAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCAGCAGGAUAA-GACCCGAAGCCGA-GUGAUC UAUGCGUUGGCAGGUUGAAGCGUGA-CGAAAGU-UGCGUGGAGGACCGCA-AGCC-GUAU UGAUAUGCAAAUCAUUGGUGUGACCUACGUAUAGGAGUGAAAGAUUAAUCGAACCCGG-C AUCAGCUGGUUCCUCCCUAAACAUGUCGCAGCAUGACCUAACC-G--------------- ------------------------------------------------------------ -------------------GAGAU-AG-UCGGUGAGGUAGAGC-ACUGAUUGGG-GGA-G CU-GG-GCG-G-GAAA--CUGCUC-ACCC-CCCUGUCAAACUCCAAACUCCCC-GA--C- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CCU-AG--AU--G-GUUGGAAGU-CCG-CAU--UA-CGGGG-UAAGCUUGUA-AU -GCGUAA-GGGAA----ACA--ACCCAGACCGU--GGUUAAU--GUCCC--UCAAUG--U A-G-GC-U-CAG--UGUCA-ACACU--G--AAAUUGGUCCUAGGUCAAAGACAACUGGAA GGUGAGCUCAG-AAGCAGCUAU-CCUUUAAAAAGUGCGUAACAGCUUACCAGUC-----A AGAUUUAGGGCGGUGAAAAUG-GACGGGGCUA-A-AGCCU---ACU--------ACA--G AGA-CCACGGA--G-C---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- ---------------------------------GG-U-GAU-CU-GG--UAGGG----AG ---G-CGCU-CUGCG-UG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------AGA AGCUG-G--G-GCGU-GA-GUU--CCAG-U-GGA-CCGCGU-A--GUGAUGAGAAUUC-U GGCAG-UAGUA-GAAGC--AUA-GUUGG-G------------------UGAGAAU----- ----------CCCAAC-CGCC-GCA-GGGGC-UAGGUUUCCU-CGGCAACGUUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GGUG-C-GUCGUAA-CUCGAA C--------------------------G-U-A---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AU-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-A--U-G--UGG------------------------ ----------------------------------------------------------UU UUAAG------------------------------------------------------- ---------------------------------UCGCA-AGA-CCC-UG-AC--GCUU-U GGGAUA--UG--C-UCAGC-G-GGA--C------UGUC-----A---UC-CCGU--CC-- -A------AGC------AC-A------U------A--------A---A-----C--UGGU G-G------A---GU-A--C--C-----G--UAA-U-GGU-GAGAA-UC--CG----G-U -G--A--AAGU-G--U--G----A-UG-G-G----------------------------- ---------GU-AA----------------------------------------CU---- AA-G----CA-AAUUC-C-UU-G-AGCC-CAUGAAA-A-G-GG----------------- ------------------------------------------------------------ -----AAU-CAC--AU---GUCCGUACCGAGAACCGACACAGGUGCCCCUCGC-UGAAGA -G-GUGUAGG-CGUGU-CGG-AUUUAAUCG-GUUAAGGGAACUCGGCAAAU-UGGCCCCG UAACUUUGGG-AUAAGGGGUGC-CU-GC--C-UG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AG-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------C--A-GGCAG-GUCGCAGUGACCGGGGCGCACUAA-----CUGUCUAA UAACAACAUAGGUGACUGC-AACUCC--GA---A-A------------GGACUA-GU-AU AGUCACUG-AUUCCUGCCCAGUGC-G-AGUAUCUGAAU-ACCGGG------------UUC A--------------ACCGGA-CGAAGGACUC-G-UAAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUUAAUG AG-U--GCGCU--ACUGUCCCUA-AC-ACG-AAUCCGUUGAACCUUUUGU-UCUAGUGCA GAGACUAGAGACUCCUGAUGGGAAGUGAAGA-CCCCGUUGAGC-UUUACUGCAGCCUGUC GUUGAAUUACGAUAAUUCUUGCGCAGUGU-AGAUGGGAG-GCGU--U-AUA--UCC--AU UGC--------------------------------------------------------- ----------------------------------UUUG--GUAAU--GG-GGAGC--CA- AUGA-UGAGACA-CCAUCCUAGUUUU-GUUGUAGUUCUCA-CUC-U-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------A-A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------C-GAGGA -CAC-CGGUAGGUGGGCAGUUUGGGUGGGGCGCCACACCCUCGA-AAAAAUAUC-AAGGG UGCCCCAAGGUCAACUCAUGUGAGUCAGAAACUCACAGAA-GAGUGUCAAGAGCAUAA-G UUGGCCUGACGC-GAUCACGCAUAGC-A-AGUGAUCGCGAGAGGAAACUCGGGUCU-AAC G-AACCAAUA------------------------UA---------G-CCUU--UU-GGU- ----------------------------GAGGCUUAUUGACUA-CAG--AAAAGCUACCA CGGGGA-UAACAGAGUCGUCGCCGGCAAGAGCACAUAUCGACCCGGCGGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCUGUGCAGCAGCAGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGGGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUAUCA --GGA--G-UGU------------------------------------------------ -----UAGAAGU-CUGAAGGUAAG-AAUGAAAUAGUACGAGAGGAACUUUCAUUCGGCGC CUC-UAGUCGA-UCGGU-UGUCU-GACA-AGGC-AG--UGCCGAGCAGCCA-C-GCGCCA -AG-GGAUAAAAGCUGAAAGCAUC--U-AAGCUUGAAACC------CGG-CCUAAAA--- --AGAGACU---------------------------UC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUA----------------------------- ------------------C---AGGAC---AUGG--G-UAAAAGACCC-GU-UUGAUAGG CUUCG-GAUGUACG-CAC-GAAG----------------------GCAA-------C--G -ACGUGU--U--CAGUC-----CGGA----A-GUACUAA-C-GUCC-AA-----A-CA-- -------- >Methanosaeta_thermophila ------------------UAUGCCAGCC-GGGGGAUG-GCU-CGGCU-CGA-G--CGC-U GAUGAAGGGCGUGCC-AAGCUGCGAUAAGCCCCGGCGAGGCGCAGG-GA-GCCUUU-GAA CCGGGGAUGCCCUAAUGGGAAA-UCCC--------------------------------- --------------AGU------------------------------------------- ----------------------------------------UU-------------CAU-G CUGAUCCG---------------------------------------------------- -----------------UAA-GGAUCGGGA-ACGCCCCGGAUUGAAACAUCUUAGUAGGG --GCAGGAGAAGAAAUCAAAACGAGAUGCCGUCAGU-AAC-GGCGAGUGAACGCGG-CAG AGCCCAAA-CCGAAUCCCGAA----------------AGG--GAGAUGUGGUGUGA---- ----------------------------UAAGACCGCU----------------C----- ------AUAACGG--------U--CUGG----CAAGGGAAU------CCG-AAGUG-GCC UG-GA-------ACGGC------C-CGCC-AAAGAGUGUGAUAGCCACGUAGGAGCAACC -A-AGC-CG---------GAU----CCGAG---CGGCGUCUUGAGUACCGUGAGUC---G GAUAUCUCGCGGGAAGUUGGGGGUCACC-AACCUCCAAGGCUAAAUACGU--CU-CGAGA CCGAUAGC-GCAGUA-GUAGGGUGACCUAAAGCUGAAA-AGAAC-CCUGGAUAGGGGUGU GAAA-AGAGCCUGAAAUCGGCUGGCGA-UGG-UGCGU-CACGGCAUGUGAGGA-CCUUCA GGCCGAA-----------------------------------GGAGGUCGU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGCGACAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGCC-UGAUG----CCGGUGUCGUGACUUACGUUUUGAAGAACGGACCAA GGAGUGCA-U----CUGGCUGGCAA---GGUUAA-UCU--C-----------GAAA---- --------GAGA-G-U-A-GCCGAAGCGAAA-GCGACA--------UGCGCGC----AUC ---------GAU-----GAGA-G----AGGCG-CGG---------------------CGU AU----------------------------------------GAAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------CG------------------ ------------------------GAGUCAGCUGGAUGC-GACCCGAAGCCGG-GCGAUC UAGGCGUGGGCAGGUUGAAGCGUGG-CGAAAGC-UGCGUGGAGGACCGCU-AGCG-GUGC UGAUAUGCAAAUCGCUCGCGUGACCUGCGUCUAGGGGUGAAAGUCCAAUCGAGCCCGG-A AAUAGCUGGUUCCUCCCGAAACAUGUCGCAGCAUGACCUGGCC-G--------------- ------------------------------------------------------------ -------------------GAGGC-AG-UCGGCGGAGUAGAGC-ACUGAUUGGG-GAU-C CC-GG-GCG-G-GAAA--CCGCUC-GCUC-UCCUGUCAAACUCCCAACACGCC-GU--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CUU-AG--AU--G-GCCGGAAGU-CCG-GGC--UG-GUGGG-UAAGCUACUA-GU -CCGUGA-GGGAG----ACA--ACCCAGACCGU--GGUUAAG--GUCCC--AAAAUG--U C-G-GC-U-AAG--UGUUA-ACACU--G--AAGGGCGUCCUAGACCUAAGACAACUGGGA GGUUAGCUUAG-AAGCAGCUAC-CCUUUAAAGAGUGCGUAACAGCUCACCAGUC-----G AGGCCUAGGGCCCCGAAAAUG-GACGGGGCU--A-AGCCG---ACU--------ACC--G AUA-CCACGGA--G-C---G--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------GG-C-GAU-CU-GG--UAGGG----AG ---G-CGCC-GCGCG-UG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGCAA-C--U-CCGU-GA-GGA--GUCG-U-GGA-CCACGC-G--GGGACGAAAAUCU-U GGUAG-CAGUA-GCAGC--AAA-GUCGG-G------------------UGAGAAU----- ----------CCCGAC-CGCC-GUA-AGGGC-CAGGGUUCCU-GGGCAACGAUCGUCAGC CCAGGG------------UUAGUCGG-UC-C-UAA----GGUG-U-GCCGUAA-CUCGAG C--------------------------A-C-A---------------------------- ------------------------------------------------------------ ----------------------------------UC---AA-AU-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-U-AC-C--GGCA----------------------- ----------------------------------------------------------CU AAAA-------------------------------------------------------- --------------------------------------------CC--G-AC--GCUU-C CGGAUA--GC--C-UGA-C-A-CCC--G------CGCC-----A---GG-GUGC--UC-- -A------AGC------GC-C------G------A--------A---G-----U--CCGC G-G------A---GA-G--C--C-----G--UCA-U-GGC-GAGAA-AC--GG----A-C -G--A--AUGC-G--U--G----A-UG-A-C----------------------------- ---------GC-AA----------------------------------------GC---- AG-G----CA-AAUUC-C-GG-G-AGCC-CGUGAAA-A-G-GG----------------- ------------------------------------------------------------ -------A-GCC--GG-A-GGCCGUACCGAGAACCAACACUGGUGCCCCGAGC-UAAGAA -G-GCUCAGG-CGUGU-CGGAAGUAAUCCG-GCUAAGGGAAUUCGGCAAAU-UAGCCACG UAACUUCGGG-AUAAGUGGUGC-CU-GC--U-UC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------A-G--A-AGCAG-GUCGCAGUGACGAGGGGGCUCUGA-----CUGUCUAA UAACAACAUAGGUGGUUGC-AGACCC--GA---A-A------------GGGCAA-GU-AC AACCACUG-AAUCCUGCCCAGUGC-G-GGUACCUGAAA-ACCCGG------------UAC A--------------ACGGGA-AGAAGGGCCC-G-UCAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCU-UAAUUGGCGGCUCGCAUGAAUGGAUCAACG AG-A--GCCCC--ACUGUCCCUA-GC-CGG-AACCCGGUGAACCUUACGU-CCCAGUGCA GAGUCUGGGGACCCCUGAUGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGCC GCUGGGUUGUGGUUCUGGAUGUAGAGCAU-AGGUAGGAG-GCGU--C-GAA--ACC--CG GGC--------------------------------------------------------- ----------------------------------GCCA--GCUCG--GGCGGAGC--CA- CCAC-UGGAAUA-CUACCCUUCUGGA-ACUACCACCCUAA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GAAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGGA -CAC-CGGUAGGUGGGCAGUUUGGGUGGGGCGCCACUCCCUAGA-AAAGAUAUC-UAGGG AGCCCUAAGGUCGACUCAGUUGGGUCGGAAACCCAACAAA-GAGUGU-AAAAGCAUAA-G UCGGCCUGACGU-CAUCCCGCAUAGC-A-AAGGAUGACGAGACGAAAGUCGGGUUU-AGC G-AACCUCUC------------------------AG---------C-CCCC--UU-GGU- ----------------------------GGGGGCGUUAGAUGA-CAG--AAAAGCUACCC CGGGGA-UAACAGAGUCGUCACCGGCAAGAGCACAUAUCGACCCGGUGGCUUGCUACCUC GAUGUCGGUUCUCUCCAUCCUGGCCGUGCAGCAGCGGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUGUCA --GGG--G-UGC------------------------------------------------ ----UUCGCGGU-CUGAGGGCAGG-CUGGCUUUAGUACGAGAGGAACAAGCCAGCGGCGC CAC-UGGUCGA-UCGGU-UGUCU-GGCA-AGGC-AC-G-GCCGAGCAGCUA-C-GCGCCA CAG-GGAUAAGGGCUGAAAGCAUC--U-AAGCCCGAAACC------CAA-CCCGAAA--- --AGAGACC---------------------------GC--U------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CCA----------------------------- ----------------------AGGGC---CCUC--G-UAAAAGACGA-GU-UCGAUAGA GUCGG-GGUGUACG-CAC-CAAG----------------------GCAA-------C--G -AGGUGC--U--CAGCC-----CGCG----A-CCACUAA-CCGCC--------------- -------- >Methanosarcina_acetivorans ------------AGGAAUUAUGCUAUCA-GGUGGAUG-GCU-CGGCU-CAA-G--AGC-U UAUGAAGGACGUGCC-AAGCUGCGAUAAGCCCGGGGUAGGUGCAUG-GA-GCCAAU-GAA CCCGGGAUUUCCGAAUGGGACC-UCUC--------------------------------- --------------CG-------------------------------------------- --------------------------------------------------------UA-G UGAUCAU----------------------------------------------------- -----------------UCA-UGAUCGGGA-ACGCUCCGAAUUGAAACAUCUCAGUAGGA --GCGGGAAAAGAAAUCAAUU-GAGAUGCCGUAAGU-AAC-GGCGAGUGAAACCGG-CAC AGUUCAAA-CCGAAUCCCUUC----------------GGG--GACAUGUGGUGUUG---- ----------------------------UAGGGCUGUU----------------C----- ------AAACGUC--------U--GGC-------GGUAAAA------UCG-AACUU-GCC UG-GA-------ACGGC------A-GACC-AUAGAGUGUGACAGUCACUUAGAUGUACGC -C-AAA-AG---------ACC----GG-AA---CAUGUCCCUGAGUACCGUGCGUU---G GAUAUCGUGCGUGAAUCUGGGGGGCACC-AACCUCCAAAACUAAAUACUC--CU-UGAGA CCGAUAGC-GAAAUA-GUAGGGUGACCGAACGCUGAAA-AGUAC-CCCGAGAAGGGAGGU GCAA-AGUGCCUGAAACCUGAUAGUGA-UGG-AACGA-UACGGCAUGAAAGGA-UCUCUG GCAUGAA-----------------------------------GGAAUCAUU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGGAUGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAAUGU-CACUG----CCAGUGUCGUAUCUUACGUUUUGAAGAACGGGCCAG GGAGUGUA-U----CUUGGUGGCAAU--GGCUAA-CCU--U----------UUAUC---- ---------UGG-G-C-A-GCCGAAGCGAAA-GCAACA--------UGUGCGC----AGC -C------UUUU-----G-GC-G----AGGCA-CGA---------------------CGU AU----------------------------------------ACAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCACCGGGGUAC-GACCCGAAGCCGG-GUGAUC UAGGCGUGGGCAGGUUGAAGCGUGG-CGAAAGC-UACGUGGAGGACCGUA-AACG-GUAU UGAUCUGCAAAUCAUUCGUGUGACCUGCGUCUCGUAGUGAAAUGCUAAUCUAACCCGG-C AUCCGCUGGUUCCUUCCGAAACAUGUCGCAGCAUGACCUGACU-U--------------- ------------------------------------------------------------ -------------------GAGAU-CG-UCGGUGGAGUAGAGC-ACUGAUUGGC-GAU-U CC-GG-GGG-A-GAAA--UCCCUC-GCUC-GCUUGUCAAACUCCAAACCCCCC-GU--C- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CCU-AG--AA--A-GUCGGAGUC-CGG-ACU--GC-UGGGG-UAAGCUUGUA-GU -CCGUAA-GGGAG----ACA--ACCCAGCCCGU--GGUUAAG--GUCCC--CAAGUG--U C-G-AC-U-AAG--UGUUA-AUACU--A--AAGGGCGUCCCAAGCCCCAGACAGCUGGAA GGUUAGCUUAG-AAGCAGCUAC-CCUUCAAAGAGUGCGUAACAGCUCACCAGUC-----G AGGUUUGGGGCCCCGAAAAUU-GACGGGGCUC-A-AGUCG---ACC--------ACC--G AUA-CCACGGA--G-U---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------GG-U-AAU-CU-CG--UAGGA----AG ---G-CGUU-GUGU-UCG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------CGA AGCAG-G--G-CUGU-GA-AGU--CCUG-U-GGA-CCGUUC-A--CAAACGAAAAUCC-U GGUAA-UAGUA-GCAGC--AAA-GCAGG-G------------------UGAGACU----- ----------CCCUGC-CGCC-GAA-GGGGC-CAGGUUUCCU-CGGCAAUGUUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GACG-U-ACCGUAA-UUCGAG U--------------------------A-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-A-UU-U--AGC------------------------ ----------------------------------------------------------GU UUAG-------------------------------------------------------- --------------------------------------------UC-UG-AC--GUCU-C AGGGCA--AG--C-CGAGC-G-GCG--U------CGUC-----G---CG-CCGU--CU-- -A------AGC------AGCG------A------A--------C---------C--CCGU G-G------A---GA-G--C--C-----G--UAA-U-GGC-GAGAA-GC--GG----G-C -G--A--AUCU-G--U--A-A--U-GG-C------------------------------- ---------AC-AA-----------------------------------------GU--- CG-G----CU-UCACC-C-CG-G-GACC-CGUGAAA-A-G-GA----------------- ------------------------------------------------------------ -------C-AGCUAAA-U-GUCCGUACCGAGAACUGACACAGGUGCCCCUAGC-UGAAAA -G-GCUAAGG-CGUGU-CGG-AGUAAUUCA-GUUAAGGGAAUUCGGCAAAU-UAGCUCCG UAACUUCGGG-AUAAGGAGUGC-CU-GC--U-GU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G UA-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------A--C-AGCAG-GUCGCAGUGACCAGGGGGCUCUAA-----CUGUCUAA UACCAACAUAGGAGAUUGC-AAACCC--GU---A-A------------GGGCUA-GU-AC AAUCUCUG-AAUCCUGCUCAGUGC-A-GGUACCUGAAA-CCCCGG------------UUC A--------------ACGGGA-AGAAGGGCCU-G-UAAACAG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUCAAUG AG-A--GCCCU--ACUGUCCCUA-AC-UGG-AGUCCGGUGAAGCUUACAU-UCUAGUGCA CAGUCUAGAGACCUCUAGGGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GUUGGGUUGUGGUUCUGGAUGUACAGUGU-AGGUAGGAG-GCAU--C-GAA--GCG--GG UGC--------------------------------------------------------- ----------------------------------GCCA--GCAUU--CGUGGAGC--CG- UCCU-UGGGACA-CUACCCUUCCGGG-ACUACGACCCUAA-CUC-U-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GAGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-GAGGA -CCC-CGAUAGGUGGGCAGUUUGCCUGGGGCGGGACGCCCUUGA-AAAGAUAUC-AAGGG CGCGCAAUGGUUGACUCAAGCGGGUCGGAAACUCGCUGAA-GAGUG-CAAGAGCAUAA-G UCAGCCUGACGU-UAUUCAGCACAGC-A-GUGGAUGACGAGACGAAAGUCGGCUCU-AGC G-AACUUUUG------------------------AG---------C-CUCC--UU-GGU- ----------------------------GGGGGCCAAAAAUGA-CAG--AAAAGUUACCC CGGGGA-UAAUUGAGUCGUUGCCGGCAAGAGUACAUAUCGACCCGGCAGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCCGUGCAGCAGCGGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUACUA --GAG--G-UGC------------------------------------------------ -----CCGAGGU-CUGCGGGUAAG-CUGCUUUUAGUACGAGAGGAACCAAGCAGCGGCGC CAC-UGGUGUA-CCGGU-UGUCC-GACA-GGGC-AU--CGCCGGGCAGCUA-C-GCGCUC -AG-GAAUAAGAGCUGAAUGCAUC--U-AAGCUCGAACUC------UGA-CCUAAA-A-- --AGAGACC---------------------------UC--U------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------A---AGGAU---UCCG--G-UAAAAGACCG-GU-UUGAUAGA AACGG-GAUGUAAG-CAC-CAAG----------------------GCAA-------C--G -AGGUGU--U--CAGUC-----CGCG----U-UUACUAA-CCAUUCGUUCC---U-UUCA -CUU---- >Methanosarcina_barkeri --------------GAAUUAUGCUAUCA-GGUGGAUG-GCU-CGGCU-CAA-G--AGC-U GAUGAAGGACGUGCC-AAGCUGCGAUAAGCCCGGGGUAGGUGCAAG-GA-GCCUAU-GAA CCCGGGAUUUCCGAAUGGGACC-UCUC--------------------------------- --------------CA-------------------------------------------- --------------------------------------------------------UA-G UGAUCAG----------------------------------------------------- -----------------UAA-UGAUCGGGA-ACGCUCCGAAUUGAAACAUCUCAGUAGGA --GCAGGAAAAGAAAUCAACC-GAGAUACCGUGAGU-AAC-GGCGAGUGAAAACGG-CAC AGUUCAAA-CCGAAUCCCUUCA---C-----------AGG--GAAAUGUGGUGUUG---- ----------------------------UAGGGCUGUU----------------C----- ------AAACGUC--------U--GGC-------GGCUAAA------CAG-AACUU-GCC UG-AA-------ACGGC------A-GACC-GUAGAGUGUGACAGUCACGUAUGUGUAAAC -C-AAA-AG---------AUC----GG-AA---CAUGUCCCUGAGUACCGUGCGUU---G GAUAUCGUGCGGGAAUCUGGGGGGCACC-AACCUCCAAAACUAAAUACUA--CU-UGAGA CCGAUAGC-GAAAUA-GUAGGGUGACCGAACGCUGAAA-AGUAC-CCCGAGAAGGGAGGU GCAA-AGUGCCUGAAACCUGAUAGUGA-UGG-AACGA-UACGGCAUUAAAGGA-ACUCUG ACAUGAA-----------------------------------GGAAACAUU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGAAUGCUG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAAUGU-CACUG----CCAGUGUCGUAUCUUACGUUUUGAAGAACGGGCCAG GGAGUUUA-U----CUCAGUGGCAAU--GGCUAA-CCU--U-----------UAUU---- ---------UGG-G-C-A-GCCGAAGCGAAA-GCAACA--------UGUGCGC----AGC UC-------UCC-----GAGC-G----AGGCA-CGA---------------------CGU AU----------------------------------------ACAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCACUGGGGUAA-GACCCGAAGCCGG-GUGAUC UAGGCGUGGGCAGGUUGAAGCGUGG-CGAAAGC-UACGUGGAGGACCGCA-AGCG-GUAU UGAUCUGCAAAUCAUUCGUGUGACCUGCGUCUCGUAGUGAAAUGCUAAUCUAACCCGG-C AUCCGCUGGUUCCUUCCAAAACAUGUCGCAGCAUGACCUGACU-G--------------- ------------------------------------------------------------ -------------------GAGAU-CG-UCGGUGGAGUAGAGC-ACUGAUUGGC-GAU-U CC-GG-GGG-G-GAAA--CUCCUC-GCUC-GCCUGUCAAACUCCAAACCCACC-GU--C- A-U--------------------------------------------------------- ------------------------------------------------------------ -----UGU-AG--AA--A-GUCGGAGUC-CGG-ACU--GC-UGGGG-UAAGCUUGUA-GU -CCGUAA-GGGAG----ACA--ACCCAUCCCGU--GGUUAAG--GUCCC--CAAGUG--U C-G-AC-U-AAG--UGUUA-AUACU--A--AAGGGCGUCCCAAGCCCAAGACAGCUGGAA GGUUAGCUUAG-AAGCAGCUAC-CCUUUAAAGAGUGCGUAACAGCUCACCAGUC-----G AGGUUUGGGGCCCCGAAAAUU-GACGGGGCUC-A-AGUCG---ACC--------ACC--G AUA-CCACGGA--G-U---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------GG-U-AAU-CU-CG--UAGGA----AG ---G-CGUU-GCGUU-CG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------CGA AGCAG-G--G-CUGU-AA-AGU--CCUG-U-GGA-CCGUUC-G--CAAACGAAAAUCC-U GGUAA-UAGUA-GCAGC--AAA-GCAGG-G------------------UGAGAAU----- ----------CCCUGC-CGCC-GAA-GGGGC-CAGGUUUCCU-CGGCAAUGAUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GACG-U-ACCGUAA-CUCGAG U--------------------------A-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-A-UU-U--AGCA----------------------- ----------------------------------------------------------AU CCG--------------------------------------------------------- --------------------------------------------UC-UG-AC--GUCU-C UGGGCA--GA--C-CGAGC-G-GCG--U------CGUC-----G---CG-CCGU--CU-- -A------AGC------AGCG------A------A--------C---------C--CCGU G-G------A---GA-G--C--C-----G--UAA-U-GGC-GAGAA-UC--GG----G-C -G--A--AUCU-G--U--U----A-UG-G-C----------------------------- ---------UA-AA----------------------------------------GU---- CG-G----UC-GCACC-C-CG-G-GACC-CGUGAAA-A-G-GC----------------- ------------------------------------------------------------ -------C-GCU--AA-AUGUCCGUACCAAGAUCUGACACUGGUGCCCCUAGC-UGAAAA -G-GCUAAGG-CGUGU-CGG-AGUACUUCA-GUUAAGGGAAUUCGGCAAAU-UAGCUCCG UAACUUCGGG-AUAAGGAGUGC-CU-GC--U-GU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GA-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------A--C-AGCAG-GUCGCAGUGACCAGGGGGCUCUAA-----CUGUCUAA UACCAACAUAGGAGAUUGC-AAACCC--GU---A-A------------GGGCUA-GU-AC AAUCUCUG-AAUCCUGCUCAGUGC-A-GGUACCUGAAA-CCCCGU------------UUC A--------------ACGGGA-CGAAGGGCCU-G-UAAACAG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUCAAUG AG-A--GCCCU--ACUGUCCCUA-AC-UGG-AAUCCGGUGAAGCUUACAU-UCUAGUGCA CAGUCUAGAGACCUCUAGGGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GCUGGGUUGUGGUUCUGGAUGUACAGAGU-AGGUAGGAG-GCAU--C-GAA--GCG--UA UGC--------------------------------------------------------- ----------------------------------GCCA--GCAUA--CGUGGAGC--CG- CAAU-UGGGACA-CUACCCUUCUGGG-ACUACGACCCUAA-CUC-U-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GAGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-GAGGA -CCC-CGAUAGGUGGGCAGUUUGCCUGGGGCGGGACGCCCUUGA-AAAGAUAUC-AAGGG CGCGCAAUGGUUGACUCAAGCGGGUCGGAAACUCGCUGAA-GAGUGC-AAGAGCAUAA-G UCAGCCUGACGU-UAUUCAGCAUAGC-A-GUGGAUGACGAGACGAAAGUCGGCUCU-AGC G-AACUUUUG------------------------AG---------C-CUCC--UU-GGU- ----------------------------GGGGGCCAAAAAUGA-CAG--AAAAGUUACCC CGGGGA-UAAUUGAGUCGUUGCCGGCAAGAGUACAUAUCGACCCGGCAGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCCGUGCAGCAGCGGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUACUA --GAG--G-UGC------------------------------------------------ -----ACGAGGU-CUGCGGGUAAG-CUGCUUUUAGUACGAGAGGAACCAAGCAGCGGCGC CAC-UGGUGUA-CCGGU-UGUCU-GACA-AGGC-AU--AGCCGGGCAGCUA-C-GCGCCA -AA-GAAUAAGAGCUGAAUGCAUC--U-AAGCUCGAACUC------UCA-CCUAAAA--- --AGAGACC---------------------------UC--A------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------A---AGGAU---UCCG--G-UAGAAGACCG-GU-UUGAUAGA AACGG-GAUGUAAG-CAC-CAAG----------------------GCAA-------C--G -AGGUGU--U--CAGUC-----CGCG----U-UUACUAA-CUAUCCGUU-----C-CUUU -CU----- >Methanosarcina_mazei -----------UAGGAAUUAUGCUAUCA-GGUGGAUG-GCU-CGGCU-CAA-G--AGC-U GACGAAGGACGUGCC-AAGCUGCGAUAAGCCCGGGGUAGGUGCAUG-GA-UCCAAU-GAA CCCGGGAUCUCCGAAUGGGACC-UCUC--------------------------------- --------------CA-------------------------------------------- --------------------------------------------------------UA-G UGAUCAG----------------------------------------------------- -----------------UCA-UGAUCGGGA-ACGCUCCGAAUUGAAACAUCUCAGUAGGA --GCUGGAAAAGAAAUCAAAC-GAGAUGCCGUAAGU-AAC-GGCGAGUGAAACCGG-CAC AGUUCAAA-CCGAAUCCCUUC----------------GGG--GAAAUGUGGUGUUG---- ----------------------------UAGGGCUGUU----------------C----- ------AAAAGUC--------U--CGC-------GGCAAAA------CCA-AACUU-GCC UG-GA-------ACGGC------A-GACC-AUAGAGUGUGACAGUCACGUAGGUGUAAGC -C-AGA-AG---------ACG----GG-AA---CAUGUCCCUGAGUACCGUGCGUC---G GAUAUCGUGCGGGAAUCCGGGGGGCACC-AACCUCCAAAACUAAAUACUC--CU-UGAGA CCGAUAGC-GAAAUA-GUAGGGUGACCGAACGCUGAAA-AGUAC-CCCGAGAAGGGAGGU GCAA-AGUGCCUGAAACCUGAUAGUGA-UGG-AACGA-UACGGCAUGAAAGGA-UCUUUG AUAUGAA-----------------------------------GGAACCACU--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGAGUGUUG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAAUAU-CACUG----CCAGUGUCGUAUCUUACGUUUUGAAGAACGGGCCAG GGAGUGUA-U----CUUGAUGGCAAU--GGCUAA-CCU--U----------UUAAU---- ---------UGG-G-C-A-GCCGAAGCGAAA-GCAACA--------UGUGCGC----AAC -CC-----UUAC----GG-GU-G----AGGCA-CGA---------------------CGU AU----------------------------------------ACAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCAUCGGGGUAC-GACCCGAAGCCGG-GUGAUC UAGGCGUGGGCAGGUUGAAGCGUGG-CGAAAGC-UACGUGGAGGACCGCA-AGCG-GUAU UGAUCUGCAAAUCAUUCGUGUGACCUGCGUCUCGUAGUGAAAUGCUAAUCUAACCCGG-C AUCCGCUGGUUCCUUCCGAAACAUGUCGCAGCAUGACCUGACU-G--------------- ------------------------------------------------------------ -------------------GAGAU-UG-UCGGUGGAGUAGAGC-ACUGAUUGGC-GGU-U CC-GG-GGG-G-GAAA--CCCCUC-GCCC-GCUUGUCAAACUCCAAACCCACU-GU--C- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CAA-AG--AU--A-GUCGGAGUC-CGG-ACU--GC-UGGGG-UAAGCUUGUA-GU -CCGUAA-GGGAG----ACA--ACCCAGCCCGU--GGUUAAG--GUCCC--CAAGUG--U C-G-AC-U-AAG--UGUAA-ACACU--A--AAGGGCGUCCCAAGCCCAAGACAGCUGGAA GGUUAGCUUAG-AAGCAGCUAC-CCUUCAAAGAGUGCGUAACAGCUCACCAGUC-----G AGGUUUGGGGCCCCGAAAAUU-GACGGGGCUC-A-AGUCG---ACC--------ACC--G AUA-CCACGGA--G-U---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUAA----------------------------- ---------------------------------GG-U-AAU-CU-CG--UAGGA----AG ---G-CGUU-GUGU-UCG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------UGA AGCAG-G--G-CUGU-GA-AGU--CCUG-U-GGA-CCGUUC-A--CAAACGAAAAUCC-U GGUAA-UAGUA-GCAGC--AUA-GCAGG-G------------------UGAGAAU----- ----------CCCUGC-CGCC-GAA-GGGGC-CAGGUUUCCU-CGGCAAUGUUCGUCAGC CGAGGG------------UUAGUCGG-UC-C-UAA----GACG-U-ACCGUAA-UUCGAG U--------------------------A-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---AA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-A-UU-U--AGC------------------------ ----------------------------------------------------------AC UGAG-------------------------------------------------------- --------------------------------------------UC-UG-AC--GUCU-C AGGGCA--GG--C-CGAGC-G-GCG--C------CGUC-----G---CG-CCGU--CU-- -A------AGC------AGCG------A------A--------U---------C--CCGU G-G------A---GA-G--C--C-----G--UAA-U-GGC-GAGAA-UC--GG----G-C -G--A--AUCU-G--U--A-A--U-GG-C------------------------------- ---------UU-AA-----------------------------------------GU--- CG-G----CU-GCACC-C-AG-G-GACC-CGUGAAA-A-G-GC----------------- ------------------------------------------------------------ -------A-GCU--AA-AUGUCCGUACCGAGAACUGACACAGGUGCCCCUAGC-UGAAAA -G-GCUAAGG-CGUGU-CGG-AGUACUUCA-GUUAAGGGAAUUCGGCAAAU-UAGCUCCG UAACUUCGGG-AUAAGGAGUGC-CU-GC--U-GU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AA-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------A--C-AGCAG-GUCGCAGUGACCAGGGGGCUCUAA-----CUGUCUAA UACCAACAUAGGAGAUUGC-AAACCC--GU---A-A------------GGGCUA-GU-AC AAUCUCUG-AAUCCUGCUCAGUGC-A-GGUACCUGAAA-CCCCGG------------UUC A--------------ACGGGA-AGAAGGGCCU-G-UAAACAG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAUCAAUG AG-A--GCCCU--ACUGUCCCUA-AC-UGG-AAUCCGGUGAAGCUUACAU-UCUAGUGCA CAGUCUAGAGACCUCUAGGGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GCUGGGUUGUGGUUCUGGAUGUACAGAGU-AGGUAGGAG-GCGU--C-GAA--GCG--UG UGC--------------------------------------------------------- ----------------------------------GCCA--GCAUG--CGUGGAGC--CA- CAAU-UGGGACA-CUACCCUUCUGGG-ACUACGACCCUAA-CUC-U-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GCGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-GAGGA -CCC-CGAUAGGUGGGCAGUUUGCCUGGGGCGGGACGCCCUUGA-AAAGAUAUC-AAGGG CGCGCAAUGGUUGACUCAAGUGGGUCGGAAACUCACUGAA-GAGUGC-AAGAGCAUAA-G UCAGCCUGACGU-UAUUCAGCACAGC-A-GUGGAUGACGAGACGAAAGUCGGUUCU-AGC G-AACUUUUG------------------------AG---------C-CUCC--UU-GGU- ----------------------------GGGGGCCAAAAAUGA-CAG--AAAAGUUACCC CGGGGA-UAAUUGAGUCGUUGCCGGCAAGAGUACAUAUCGACCCGGCAGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCCGUGCAGCAGCGGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUACUA --GAG--G-UGC------------------------------------------------ -----ACAAGGU-CUGCGGGUAAG-CUGCUUUUAGUACGAGAGGAACCAAGCAGCGGCGC CAC-UGGUGUA-CCGGU-UGUCU-GACA-AGGC-AU--CGCCGGGCAGCUA-C-GCGCUA -AG-GAAUAAGAGCUGAAUGCAUC--U-AAGCUCGAAAUC------UGA-CCUAAAAA-- ---GAGACC---------------------------UU--U------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------A---AGGAU---UCCG--G-UAGAAGACCG-GU-UUGAUAGA AACGG-GAUGUAAG-CAC-CAAG----------------------GCAA-------C--G -AGGUGU--U--CAGUC-----CGCG----U-UCACUAA-CUAUCCGUU-----C-C--- -------- >Methanosphaera_stadtmanae ------------------UAUGCCAUCU-GGGGGAUG-GCU-AGGCU-UGAGAUUAAC-U UAUGAAGGUCGUGGC-AAGCUGCGAUAAGCCUGGGCGAGAAGCAUG-CA-UUCAUU-GAA CCUGGGAUUGCCGAAUGAGAUU-CUUA--------------------------------- -------------UUAC------------------------------------------- ----------------------------------------UC-------------UUU-A CCGAGUAAUGAUCCA--------------------------C------------------ --------------ACUUGU-GGAUUGGGA-ACCCACUGAAUUGAAACAUCUUAGUAGGU --GGAGGAAGAGAAAACAAUU-GUGAUGCCGUUAGU-AAC-GUCGAGCGAAAACGG-UAU AGGACAAA-CUGAAUCCCUACUA--GAA---AUUAAUAGG--GAGAUGUGGUGUUG---- ----------------------------AAGAUUCAAAAUAU-----------UU----- ------AUGGUGG-----CCUG--UUAU----U-AUCCUUG------UUU-AAUUAUUGU UG-GA-------AUACU------UUAACC-GUAGAGGGUGAUAGUCCCGUAGACUUUGGG -GUAAU-UU---------GGU----CAUUUUUUUUUGAAUUCGAGUAGCGUUCAUU---G GAAAUUGGGCGUGAAU--GGGAGGCAUC-GACUUCCAAUUCUAAACAUUA--CU-CAAGA CCGAUAGU-GUAUUUAGUACCGCGAGGGAAUGCUGAAA-AGAAC-CCUUU-UAG-GGGGU GAAA-AGUACCUGAAACCAGAUGGUGA-CAG-CCUGG-CAUGGCAUGAAAGGAAUGAUAA UUCAU-----------------GAAUUUC---------UUCUGGCAACACU--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GAAAUUCUUU-G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----U---------CUUUG---ACUAGUGUUGUGUCAUUCGUCUUGAAACACGAGCCAG GGAGUUUG-U----AGUUGUGGCGA---GGCUAA-AAA--G----------CUUAAG--- --------CUUU-G-U-A-GUCGCAGGGAAA-CCGAGU--------AAGACGU----AAC -U------UUUU-------GU-G----UGGUU-CUG---------------------AUU AU----------------------------------------AAA--------------- ---------------------------------------------AUGUC---------- ----------------------------------------A------------------- ------------------------UAGUCACAGCUUUAA-AACCCGAAGCCGG-UCGAUC UAUCCGUGAGCAGGAUGAAAUCGCU-CAUACGA-GUGAUGGAGGUUCGC--AGAG-UUGU UGUUCUGCAAAACACUCUUAUGACUUGCGGUUAGUGGUGAAAGGUCAAUCAAGAUCGG-U GACAGCUGGUUCCUAUCGAAAUAGCUCCAAGGCUAGACUGAUU-G--------------- ------------------------------------------------------------ -------------------GAGAU-AG-CUGGCAAGGUAGAGC-ACUGAUUGAG--UG-U UUAGG-GUG-G-GAAA--CUACUC-GGCA-UUCUGUAAAACUCCAAACUUGCU-AG--C- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AA--G-AUCGG-AUC-GAG-GGG--CG-UGGGG-UAAGCCUGUG-UC -CCGAAA-GAGAA----ACA--ACUCAGACUUU--GGUUAAG--GUCCC--CAAGUG--C C-G-GA-U-UAG--U------U-U---A--AGGGA-GUCAUUAGCCCUAGACAGUGGGGA GGUGGGCUUAG-AAGCAGCCAC-CCUUUAACGAGUUCGUAACAGAUCACCCAUC-----G AGGUUAAUGGCAUCUAAAAUG-GAAGGGGUU--A-AGUCG---GCC--------ACC--G AUA-CCAAUGA--ACA---U--A----UA-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUU------------------------------ ----------------U----G---------UAUA-U-GAU-UU-CG--UAGAU----AG ---G-CGUC-CUGU-UGG------------------AU-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------UGA AGCUG-G--G-GUGU-GA-AUU--CCAG-U-GGA-UCUUGC-A--GGAAUGUGGAUCC-U GGUAG-UAGUA-GCAGC-A-AA-GUAAA-G------------------UGUGAAU----- ----------CUUUAU-CGCC-GAA-GGGGC-UAGGGUUCCU-UGGCAAUGUUCGUCAGC CAAGGG------------UUAGGCGG-UC-C-UAA----GGGU-A-ACGGUAA-UUCCAG U--------------------------U-A-U---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GU-CC-A-AC-A--CAAU-U-U--AC-----A--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGUUU----------------------AUGUU-GGA-UUA----AC--ACUU-C GUGAUA--UG--C-CUUGU-A-AGA--U-----UGUC------G---UC-UUAUU-CA-- -A------AUU------UU-A------G------A--------A---G-----C--UAAG G-G------A---GA-A--C--U-----G--UAA-U-AGU-GAGAA-CU--UG----G-U -G--U--AUUU-A--U--G-A--U-GA-G-UCUCUCG----------------------- ---------UUUUU--------------------------------UU-GAG--AUU--- UG-G----UU-GAUUC-A-UG-G-AGUC-CUUGAAA-A-G-AAAA---U--A-UCC-AU- UUA--------------------------------------------------------- -U--UUGA-UUG--UG-U-UUCCGUACCGAGAUCCGACACAGGUGCCCCUAGU-UUAGUA -G-ACUUAGG-CGUGU-UAGGG-UAAACCA-GCUAAGGGAAUUCGGCAAUU-UAGCUCCG UAACUUUGGG-AUAAGGAGUGC-CA-GC--U-AC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G UG-UA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------G----U-AGCUG-GUCGCAGUGACUAGGGAGGUUCGA-----CUGUUUAA UAAAAACAUAGCUCCCAGC-UAGCCC--GU---A-A------------GGGUGU-GU-AC UGGGGGCG-ACACCUGCCCAGUGC-U-GGCACGUGAAG-CUGGGG------------UUC A--------------ACCUGG-UGAAGCGCCA-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUGCCUUGCCGGA-CAAGUACCGGCCUGCAUGAAUGGUAGAACG AA-A--UCUCC--ACUGUCCCUA-GC-UGG-AACCUAGUGAACCUGCUAU-UCUGGUGCA CAAGCCAGAGACUUCUAUUGGGAAGCGAAGA-CCCCGUAGAGU-UUUACUGCAGUCUGCU AUUGAGGCUUGGUUGCAAGUAUGCAGCGU-AAGUAGGAG-ACUU--C-GAC--GGU--AU GUC--------------------------------------------------------- ----------------------------------GUCA--GGCAU--AUCUGAGU--CA- UUCA-UGAGACA-CUACUUUCUUGUG-ACUGUGUUUCUAA-GCU-A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------UUUUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-UAGGA -CAU-UGGUAGAUGGGCAGUUCGGCUGGGGCGGUACGCGUUUGA-AAAGAUAUC-AAACG CGCCCAAAGGUUGGUUCAAGUGGGACAGAGAUCCACUGUA-GAGUGU-AAGGGCAUAA-G CCAGCCUGACUG-UAUUUCGAACA--GUAAGAAAUUCAGAGGCGAAAGCCGGGCCU-AAC G-AACCUCAA------------------------UG---------U-CCUC-GUC-GAU- ----------------------------GGGGGCUUGAGAUGA-CAG--AAAAACUACCU CGGGGA-UAACUGGGUGGUCGCAGGCAAGAGCCCAUAUCGACCCUGCGGCUUGCUACUUC GAUGUCGGUUCUUUCCAUCCUGGGUGUGCAGCAGCACCCAAGGGUGGGGCUGUUCGCCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUGGUUGCUAUCUAAUA --GAA--G-UGU------------------------------------------------ ----UUUGUUGC-UUGAGCGGAAG-GUGGUUCCAGUACGAGAGGAACGAGCCGUCGGUGU CUC-UGGUCUA-CCAGU-UGUCU-GAUA-AGGC-AU--CGCUGGGCAGCUA-C-GCACUA -UGAUAAUAAAGGCUGAAAGCAUC--U-AAGCCUGAGGUA------UU--CCGUGAAA-- --AUAAGCA---------------------------GC--UU--U--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UU------------------------------ ------------------U---AGGGU---AUGA--G-UAGAAGACUU-GU-UUGAUGGG AUUGG-GAUGUAAG-CUU-CGAG--------------------AUUCUU-UGUUUUC--G -AGUUGU--U--AAGUC-----CGCA----A-UUUCCAA-CACCCGAUU-------UUAA -UACAAU- >Methanospirillum_hungatei --------------UUCUUACGCCUGUC-AGUGGAUG-GCU-CGGUU-CGG-G--UGC-C GACGAAGGGCGUGCC-AAGCUGCGAUAAGCUCCGGGUAGACGCAUG-GA-GUCAUU-GAA CCGGAGAUCCCCGAAUAGGACA-UCCA--------------------------------- -------------GAUG------------------------------------------- ----------------------------------------CA-------------UAA-A GCAUCAUUCCG------------------------------------------------- ---------------CCAUC-GGAAAGGGA-ACGCCCCGAAUUGAAACAUCUUAGUAGGG --GCAGGAGAAGAAACCAACC-GGGAUGUCGUUAGU-AGA-GGCGAUCGAACACGA-CAG AGUUCAAA-CCGAAUCCUUC------------------GG--GAGAUGUGGUGUAU---- ----------------------------GGACCGC----GGC-----------AU----- ------AAGAUUU-------------GC----A-UUCAGAA------CUG-AAGUU-ACC UG-GA-------ACGGU------A-UACC-AGAGAGGGUGACAGUCCCGUAUGUGUAUGC -A-UGC-AG---------ACU-----UUAG---CGGUAUCCUGAGUAGCGUGGGUC---G GAAUUCCCGCGUGAAUGUGGGGGUCAUC-AACCUCCAAAACUAAAUACUC--CC-CGAAA CCGAUAGC-GUAGUA-GUAGCGUGAGCGAAAGCUGAAA-AGCAA-CCCUGGAAAGGUGUU GAAA-AGUGCCUGAAACUGACAGGUUA-UCG-CGUGA-UACGGCACGAAAGGA-UCUUCA AAGCGAA-----------------------------------GGAACGAGU--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGACUCAAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGGGUU----UUGU-UGCCGGUGUCGUAUCGUACGUUUUGAAGAACGGGCCAG AGAGUUUA-U----UCUGUUGGCGA--CGGUUAA-UUU--C-----------UAU----- --------GAAA-G-A-A-GCCAGAGGGAA-ACCAACA--------AGUCCGC----AGC -C------GUAA-----G-GU-C----AGGGA-CGA---------------------CGU ACU---------------------------------------ACC--------------- -------------------------------------------A-GUGCG---------- ----------------------------------------UG------------------ ------------------------GAGUCAGCAGGAUAA-GACCCGAAGCCCG-GCGAUC UAUGCGUGGGCAGGUUGAAGCGUGC-CGAAAGG-UGCGUGGAGGACCGCA-AGCG-GUUU UGAUAUGCAAAUCAUUCGCGUGACCUGCGUAUAGGAGUGAAAGAUUAAUCGAGCCGGG-C AUCAGCUGGUUCCUCUCGAAACAUGCCGUAGCAUGACCUGAUC-U--------------- ------------------------------------------------------------ -------------------GAGAU-CG-ACAGUGAGGUAGAGC-ACUGAUUGGG-GAA-G CU-GG-GGA-A-GAAA--UUCCUC-ACUC-UCCUGUCAAACUCCAAAUUCCCU-GU--C- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CAG-CG--AC--G-AUCGGAAGU-CCG-CAU--UA-CGGGG-UAAGCUUGUA-AU -GCGUAA-GGGAG----ACA--ACCCAGACCGU--GGUUAAU--GUCCC--UCAGUG--C A-G-GC-U-CAG--UGUAA-ACACU--G--AAAGUAGUCCUGGGUCAAAGACAACUGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUUUAAAAAGUGCGUAACAGCUUACCAGUC-----A AGAUUCAGGGCGCUGAAAAUG-GACGGGGCUU-A-AGCCU---GCC--------ACA--G AUA-CCACGGA--C-C---A--U----AC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAUU---------------------------- --------------------------------GUA-U-GAU-GG-CG--UAGAG----AG ---G-CGUC-CUGC-AUG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGCAG-G--G-UUGC-AA-GAU--CCUG-U-GGA-CCGUGC-A--GGAAUGAAAAUUC-U GGCAG-UAGUA-GAAGC-UUAA-GAUUG-G------------------UGAGAAU----- ----------CCAAUC-CGCC-GCA-GGGGC-UAGGUUUCCU-CGACAAUGUUCGUCAGU CGAGGG------------UUAGUCGG-UC-C-UAA----GACG-U-ACCGUAA-UUCGAG U--------------------------A-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAC-AGG--U UAA----UAUU-CCU----GUACC-U-GU-A--UCA------------------------ ----------------------------------------------------------AA CAAU-------------------------------------------------------- --------------------------------------------CC-UG-AC--GCUU-U CGGAUA--GG--C-AUUGC-G-GAG--U------CAUC-----G---CU-CCGU--CU-- -A------AGC------CGGA------U------A--------U---G-----A--AAUU G-G------A---GU-A--C--C-----G--UAA-U-GGU-GAGAA-UU--UU----U-C -A--A--AACG-G--U--G----A-UG-G-G----------------------------- ---------GU-AA-----------------------------------------CA--- AU-G----CU-GAUUC-C-AG-G-AGCC-CGUGAAA-A-G-GG----------------- ------------------------------------------------------------ -------U-GAU--AC-G-GUCCGUACCGAGAACUGACACAGGUGCCCCUCGC-UGAGAA -G-GCGAAGG-CGUGU-CGGGAGUAAAUGU-GUUAAGGGAACUCGGCAAAU-UAGCCCUG UAACUUUGGG-AUAAGGGGUGC-CU-GC--C-CA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------U--G-GGCAG-GUCGCAGUGACAAGAUCGCUCCGA-----CUGUCUAA UAACAACAUAGCAGACUGC-AACUCC--GA---A-A------------GGACUC-GU-AU AGUCUGUG-AUUCCUGCCCAGUGC-G-AGUAUCUGAAC-ACCGGG------------UUC A--------------ACCGGA-CGAAGGACUC-G-UAAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGUCGCU-UAAUUGGCGACUUGCAUGAAUGGAAUAACG AG-A--GCGAU--ACUGUCCCUA-AC-ACA-UACCCGUUGAACCUUUUGU-ACUAGUGCA GAGACUAGUGACUCCUUAUGGGAAGUGAAGA-CCCCGUGGAGC-UUUACUGCAGCCUGUC GUUGGGUUACGGUAUUACCUGCGCAGGGU-AGAUGGGAG-ACGU--C-GAU--CCA--AC CCU--------------------------------------------------------- ----------------------------------UGUG--GGGGU--UGGUUAGU--CA- CCGA-UGAGACA-CCAUCCUGGUUUU-AUUGUAAUUCUAA-CUG-A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------UUUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------U-CAGGA -CAU-CGAUAGGUAGGCAGUUUGGGUGGGGCGCCACACCCUCGA-AAAAAUAUC-AAGGG UGCCCUAAGGUCAACUCAAGCGGGUCAGAAACCCGCUGAA-GAGUGUCAAGAGCAAAA-G UUGGCCUGACGC-GAUUUCGCAUAGC-A-AGAAAUCGCGAGAGGAAACUCGGGUCU-AAC G-AACCAAUA------------------------CG---------C-CCUG--UU-GAU- ----------------------------GAGGGCUAUUGACUA-CAG--AAAAGCUACCC CGGGGA-UAACAGAGUCGUCGCCGGCAAGAGCACAUAUCGACCCGGCGGCUUGCUACCUC GAUGUCGGUUCUUUCCAUCCUGGCUGUGCAGCAGCAGCCAAGGGUGAGGUUGUUCGCCUA UUAAAGGGGAUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGUUACUAUCUAUAA --GGA--G-UGU------------------------------------------------ -----UGGAAGU-CUGAAGGCAAG-AAUGAAAUAGUACGAGAGGAACUUUCAUUCGGCGC CAC-UGGUCUA-CCGGU-UGUCU-GACA-AGGC-AA--CGCCGGGCAGCUA-C-GCGCCA -AG-AGAUAAAAGCUGAAAGCAUC--U-AAGCUUGAAACU------CAG-CCUGAACA-- --AGAGACU---------------------------UC--A------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UG------------------------------ ------------------A---AAGAC---ACGG--G-UAAAAGACCC-GG-UUGAUAGG UUCGG-GAUGUACG-CAC-GAAG----------------------GCAA-------C--G -ACGUGU--U--CAGUC-----CGCG----A-AUACUAA-UCGUCU-UA-----A-UAAC -GUC---- >Methanothermobacter_thermautotrophicus ------------CUUAUUUAUGCCGUCU-GGGGGAUG-GCU-UGGCU-UGAGU--CGC-U GAUGAAGGCCGUGGC-AAGCUGCGAUAAGCCCAGGGGAGGAGCAUG-CA-UCCUUG-GAU CCUGGGAUUGCCGAAUGGGACU-UCCU--------------------------------- -------------GGCC------------------------------------------- ----------------------------------------GU-------------CCC-U GCACUCUGUGCG----GG-------------GGCUGG-U-CACUCCCCUUU-U------- --------------CUUGGG-GGAGGGGGA-ACCCGCUGAACUGAAACAUCUUAGUAGGC --GGAGGAAGAGAAAGCAAUAUGCGAUGCCGUGAGU-AAU-GGCGAAUGAAAGCGG-UGG AGGACAAA-CUGAAUCCAUCAUG--GU----GACGUGGUG--GAGAUGUGGUGUUG---- ----------------------------CGGACCCCCUGCU-------------U----- ------AGGGGUU-----CCAG--GUGU------GGUUGGG------UUG-AACUUGGGC UG-GA-------AUGCC------CGGGCC-GUAGAGGGUUAAAGCCCCGUAGACUUGCUG -U-GCC-UG---------GCC-----CUGCGGGGGUGUUCCUGAGUAGCGUCCAUU---G GAUAUUGGGCGUGAAGCUGGGAGGCAUC-GACUCCUAAUCCUAAACACGU--CU-CAAGU CCGAUAGC-GAACUA-GUACCGUGAGGGAAAGCUGAAA-AGUAC-CCCUGAUAGGGGUGU GAAA-AGUGCCUGAAACCAGGCGGUGA-CAG-CCCGG-CACGGCAUGGAAGGAAUGAGGC UUGCCCUG--------------------------------UAAGAAACCAU--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCAACAUGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAUGUGGGC---UGGCUGAUCAGUGUCGUGUCAUCCGUCUUGAAACACGGGCCAG GGAGUUUA-G---UGGUUGUGGCGA---GACUAA-GAA--G-U-G-------UGU----- ------CGCUUU-G-A-A-GUCGUAGGGAAA-CCGACA--------GGUCCGC----AGC AGC----AUCUGU---GCUGU-G----AGGGA-CGG---------------------GGU CU----------------------------------------UAAUA------------- ---------------------------------------------GGGCC---------- ----------------------------------------UG------------------ ------------------------GAGUCACAGCCCUAA-AACCCGAAGCCGG-UCGAUC UAGCCCUGGGUAGGAUGAAGUCGCU-CUUACGA-GUGAUGGAGGUCCGC--AGGG-GUGU UGUCGUGCGAAACAUUCCUCUAACCUGGGGUUAGUGGUGAAAGGCCAAUCAAGGCCGG-U GACAGCUGGUUCCACCCGAAAUGGCUCGUAGGCCAGCCUGACU-G--------------- ------------------------------------------------------------ -------------------GAGGU-UG-GUGGCGGGGUAGAGC-ACUUAUUGGG--UG-U UUAGG-GGG-A-GAAA--UCCCUC-GGCA-UCCUGUAAAACUCCGAACUCGUC-AC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----UGU-UG--AA--G-GUUGG-AGU-CAG-GGG--CG-CGGGG-UAAGCCUGUG-UC -CCGAGA-GAGGA----ACA--ACUCAGACUGG--GGUUAAG--GUCCC--UAAAUG--C C-G-GC-U-AAG--U------C-U---A--AGGGG-GUCUUUGGCCCUAGACAAUGGGAA GGUGGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUUCGUAACAGAUCACCCAUC-----G AGGUCAAAGGCACCGAAAAUG-GAGGGGAAUU-A-AGCCG---GCU--------ACC--G AUA-CCUCAGA--G-C---A--C----CA-C---------------U------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UUUG----------------------------- ---------------------U---------GUGG-U-GGU-CU-UG--UAGGG----UG ---G-CGUC-CCGU-UGG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------UGA AGUGG-G--G-GCGU-GA-GCU--CCUG-U-GGA-CCCUGC-G--GGAAUGAGGAUCC-U GGUAG-UAGUA-GCAGC-A-AA-GUGAG-G------------------UGAGAAU----- ----------CCUUAC-CGCC-GGA-GGGGC-UAGGGUUCCU-UGGCAAUGUUCGUCAGC CAAGGG------------UUAAUCGG-UC-C-UAA----GGCC-A-UGGGUAA-UGUCCA UG-------------------------U-G-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA-AA-GGGU-AAC-AGG--U UAA----UAUU-CCU----GUACG-G-UC-C--AGGU-A-C--U-U----G--C----G- -----------------------------------------------------------G UGA--------------------------------------------------------- ------CGC-U----------------------GGGUUGGGC-UUC-UG-AC--GCUU-C GGGGUA--GG--C-UGAGC-G-GGA--U-----UUUC------G---UC-CUGUU-UA-- -A-------GG------GU-U------G------A--------A---G-----C--CUGG G-G------A---GA-G--C--C-----G--UAA-U-GGC-GAGAA-CUAUUG----G-U -G--A--AGGC-C--U--G-A--A-UA-G-CCACUCC----------------------- ---------UUGUU--------------------------------GG-GUG--GUU--- CG-G----CU-GUGCC-C-UG-G-AGUC-CUUGAAA-AGG-GAGU---C--C-UU--CU- UG---------------------------------------------------------- -G--GAUC-CUG--GA-U-CGCCGUACCGAGAUCCGACACUGGUGCCCCUAGC-UGAGUA -G-GCUAAGG-CGUGU-UGGGG-UAACCUG-GCUAAGGGAAAUCGGCAAAU-UAGCCCCG UAACUUUGGG-AGAAGGGGUGC-CA-GC--C-AU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G UA-G-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------A--U-GGCUG-GUCGCAGUGACAGGGGGGGCCCGA-----CUGUUUAA UAAAAACAUAGCUCCUAGC-UAGCCC--GU---G-A------------GGGUGU-GU-AC UGGGGGCG-ACACCUGCCCAGUGC-C-GGCACGUGAAG-CCCUGG------------UUC A--------------ACGGGG-UGAAGCGCCG-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUGCCUUGCCGGA-UAAGUACCGGCCUGCAUGAAUGGUUGAACG AG-G--UCCCU--ACUGUCCCUA-GC-CAG-GACCUGGUGAAGCUGCUGU-UCUGGUGCA CAAGCCAGAGACUCCCAGUGGGAAGCGAAGA-CCCCGUAGAGC-UUUACUGCAGUCUGCU GUUGGGGCUUGGUCAUGGGUAUGCAGUGU-AGGUGGGAG-GUGU--C-GAU--GCCA-UG GUC--------------------------------------------------------- ----------------------------------GCCA--GGCCGU-GGUGGAGC--CG- GUCA-UGAGACA-CCACCUUCCUGUG-ACUGUGUCUCUAA-CCC-C--UC--------G- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------UUUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------U-GGG-GGGGA -CAU-CGGUAGAUGGGCAGUUUGGCUGGGGCGGCACGCGCUUGA-AAUGGUAUC-AAGCG CGCCCUAAGGUCGGCUCAGGCGGGACAGAGAUCCGCUGUA-GAGUGU-AAGGGCAUAA-G CCGGCUUGACUG-UGCUCCUACUA--GUAGGGGGUGCAGGUGCGAGAGCAGGGCCU-AGC G-AACCCCAG------------------------AG---------U-CCUC-GUC-GGU- ----------------------------GGGGGCCUGGGAUGA-CAG--AAAAGCUACCU CGGGGA-UAACUGGGUGGUCGCAGGCAAGAGCCCAUAUCGACCCUGCGGCUUGCUACUUC GAUGUCGGUUCUUUCCAUCCUGGGUGUGCAGCAGCACCAAAGGGUGGGGUUGUUCGCCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUGGUUGCUAUCUACUG --GGA--G-UGU------------------------------------------------ ----GUGGUUGC-CUGAGGGGAAG-GUGGUUCCAGUACGAGAGGAACGGACCGUCGGCGC CUC-UGGUUUA-CCGGU-UAUCC-GAGU-GGGU-AU--UGCCGGGCGGCUA-C-GCGCUA -UGAUUAUAAAGGCUGAAGGCAUC--U-AAGCCUGAGGUU------UUC-CCUGAAA--- --AUAGGCG---------------------------GC--UU------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------G---UGGAC--CGCGG--G-UAGAAGACCU-GU-UUGUUGGG GCGGG-GGUGUGAG-CUU-CGAGGCC--UG---------------UUUU--UGGGUC--G -AGUUGU--U--UAGCC-----UGCC----G-UUUCCAA-G-GUUU-UU-----U-GUCC -CU----- >Nanoarchaeum_equitans ----------------CUGACCCCGCCC-GGUGGAUG-CCU-GGGCU-CGG-G--AGC-C GAAGAAGGGCGUGGC-AAGCUGCGAUAAGCCAGGGGGAGGCGCACG-CA-GCCGUU-GAU CCCUGGAUCCCCGAAUGGGACC-UCCU--------------------------------- -------------GCCC------------------------------------------- ----------------------------------------GG-------------GGG-U UAACCCCG-------GGC-------------GCCCCG-A-U------------------- ------------------AA-GGGGCGGGA-ACGCGGGGAAGUGAAACAUCUCAGUACCC --GCAGGAAAAGAAAGAGAAAUUCGAUGGCGGGAGU-AGG-GGCGACCGAAACCGC-CGU AGCCCAAA-CUGAAUCCCGUAG---GGA---AACCUACGG--GAGAUGUGGGGUUG---- ----------------------------UUGGGGGU----GGC--------GGCU----- ------U------------UCC--CUCC----CGCGGGAAC------CCG-AACUC-CGG UG-GA-------AC-CG------G-GGCC-GUAGAGGGUGACAGCCCCGUAGGGGUAACC -GCGGA-GG---------G-------AGUGCCGCCACUUCCAGAGUACCGCGCCUC---G GAUAUGGCGCGGGAAGCUGGGGGACACA-CGCCCCCAAGGCUAAAUACUC--CC-CGAGU CCGAUAGC-GGACUA-GUAGGGUGACCGAAAGGUGAAA-AGAAC-CCGUGGAAG-GGAGU GAA--AGAGCCUGAAACCGGGCGGGGA-UAG-UCAGG-UGGGGCCGG------UUAAGC- CCCCGAA-----------------------------------GGAACCCCC--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACGGGGUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACUUGCUAG---------CC--GGUUCCACCGUACGUUCGGGAGCACGUGCGGG GGAGUGUG-C----CCGAGUGGCGA---GGUUAA-GGG--G----------AUAAA---- --------CCCC-G-A-A-GCCGUAGGGAAA-CCGA---------AGGCCCGC----AGC CC------UUAU-----GGGC-G----AGGGG-CCG---------------------CGU CC----------------------------------------UAU--------------- -------------------------------------------A-CGGGC---------- ----------------------------------------GU------------------ ------------------------AAGUCACUCGGGCAC-GACCAGAAGCCCG-GCGAUC UACCCCGGGGCAGGGUGAAGCGGGG-UU-UUUC-CCCGUGGAGGCCCGAA-GGGG--UGG UG--GC-CUAUCCCCUCCUCUGACCCCGGGGUAGGGGCGAUAUACCAAUCGAGCCGGG-U GAUAGCUGGUUCCCGCCGAAAUGGGCUGCAGUCCAGCCUCGGC-G--------------- ------------------------------------------------------------ -------------------GAGGC-A--CCCUCGGGGUAGAGCGACGGAUUCCC--GU-G GCAAG-GGG-G-UUAA--CCCCAC-CACG-GG-AGUCCAACUCCGAACCCGAG-GG---- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-CCGGG-AGA-CGG-GGG--CG-GCG-GAUAAGCCGCCG-UU -CCGAGA-CGGGA----ACA--ACCGAGACCGG--GGUUAAG--GCCCC--UAAGUG--C C-G-GC-U-AAG--UGG----CUG---G--AAGGGUGUCCGCUCCCUAAGACACCGGGGA UGUGGGACUAG-UAGUGUCCAU-CAUCUAAGGAGUGUGCAACAACUCACCCGGC-----G AGGGAGCGGGCCCCGCAGAU-GGACGGGCCU--A-AGCCG---GCC--------GCC--G AGA-CCCCGGG--C-C---G--G----GG-A---------------UC-C---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAU------------------------------ ---------------GG----A---------UCCC-C-G-U-GC-GG--UAGGC----GG ---G-CGUC-CCGG-UG-------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGGCG-G--G-CCGU-GA-GGU--CCGC-U-GGA-GCCGCC-G--GGAAUGAGAAUCC-C CGCGU-GAGUA-GGAGC-A-AA-GAGGG-G------------------UGAGAAG----- ----------CCCCUC-CGCC-GAAAGGGAA-AAGGGUUCCC-UGGCAAUGACCAUCAGC CAGGGG------------UGAGUCGG-UC-C-UAA----GGCC-G-GCGGUAA-CUCCGC U--------------------------C-G-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAG-GGG--U UAA----UAUU-CCC----CUACC-G-CC-C--GGGU-A-G--G-C----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGCCA----------------------AG-CCCUAC-UCC-CG-AC--GCCU-G GGGCUA--GG--C-CGACC-G-CGG--A-----UUU-------C---CC-GCGG--CC-- -A------ACC------GGGA------U------A--------G---G-----G--CCGG G-G------A---GU-G--C--C-----A--UUA-U-GGC-GAGAA-CC--GG----C-C -A--A--ACCC-G--G--G----A-CG-G-GGC-CCCC---------------------- ---------GU-AU--------------------------------GG-GGG--CUU--- CG-G----CC-GAGCC-C-U--G-GGCC-CAUGAAA-A-G-GGAG---U--A-GGG-AA- ------------------------------------------------------------ -C--GAUC-CCG--GG-C-GACCGUACCGAGAACCGUGACAGGUUCCC-UGGG-UGAGCA -G-CCUAAGG-CG-GU-GGGGUAUAACCUG-GCCGAGGGAAAUCGGCAAAU-UGGCCCCG UAUCUUCGGU-AGAAGGGGUGC-CU-GC--G-GU-CGUGGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U A---A------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------U-C----- C-----UGC-G-A--C-CGCAG-GUCGCAGUGACAAGGGCGGGCCGA-----CUGUUUAC UAAAAACAUAGCCUCCGGC-AAGCCC--GA---A-A------------GGGUGU-GU-AC CGGAGGUG-ACGCCUGCCCAGUGC-C-GGUACCUGAAC-CCCCCG------------UCC A--------------AGGGGG-CUAAGGGCCG-G-UAAACGG-CGGGAGUAACUGUAACU CUCUUAAGGUAGCGUAGUCCCUUGCCGGU-UAAAUGCCGGCUUGC--GAACGGCGUAACG AG-C--UCGCC--ACUGUCCUCG-GC-CAG-GGCCCCCUGAAAACGCCGU-UCCCGUGGA UAGGCGGGAGAGGCCCGGUGGGAAGAGAAGA-CCCCGUGAAGC-UUAACCGCAGCCUGUC GUUGCCCCGUUGUCCCCCACGCUCAGCGU-AGCGGGGAG-CGAU----GAA--CCG--GC CCC--------------------------------------------------------- ----------------------------------UCCG--GGGGU--CGGGGAUG--CG- CCCA-UGAGACA-CCCGCCGUGGGGG-ACAACGGGGCUAA-CCC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-AAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GGGGA -CAG-CGGCAGGUGGGCGGUUUGGCUGGGGCGGCACACCGCCGA-AAAGAUAUC-GGCGG UGCCCAAAGGUCGGCUCAGGCGGGUCAGAAAUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACAC-GGCCCUUUA-----CAAGGGGCCGUGGCGGGAAACCGCGGCCU-AGC G-AACCCCGG------------------------UA---------G-CCCC--CG-UGU- ----------------------------GGGGCUUCGGGACGA-CGG--AAAAGCUACUC CGGGGG-UAACAGCUUGGUCGCGGGCGAAAGUUCCCAUCGACCCCGCGGUUUGAGACCUC GAUGUCGGCUCUUCUCACCCUGGCCGUGCAGCAGCGGCCAAGGGUGGGGGUGUUCACCCA UUAAAGAGGAACGUGAGCUGGGUUUAGUACGCCGCGAGGCAGUGUGGAUUCUAUCUACCG --GGC--C-UGU------------------------------------------------ -----UCGGCGG-CUGAGGGGAAG-GACGGCCUAGUACGAAAGGAACGGCCGUCCGGCGC CUC-UAGUCGA-CGGGG-UGUCC-GUAU-GGGC-AG--CCCCGG-CAGCCA-C-GCGCUA -GG-GGGUAAGGGCUGAAUGCAUC--U-AAGCCCGAACCC------CUC-CCCGAAA--- --AGAGCCG---------------------------CC--GAU----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CCCCC---UCGG--G-UAGAAGACCC-GG-UUGAUGGG GGGGC-GGUGGAAG-CCC-CGAGGGU--U-U--------------CCGA----------- --GGGGC--G---AGCC-----GGCC----C-CUCCCAA-UCGGGG-GG---UGGUCCUG -CG----- >Natronomonas_pharaonis ----------GUGGCUACUGUGCCAUCU-GGUGAAUA-GCU-CGGCU-CAG-G--CGC-C GACGAAGGACGUGUC-AAGCUGCGAUAAGCCUCAGGGAGCCGCACG-AA-GGCAAA-GAA CUGAGGAUCUCCUAAUGGGAAU-CCCC--------------------------------- -------------ACCG------------------------------------------- ----------------------------------------CA-------------AUU-G CUU--------------------------------------------------------- ----------------CGCG-CAAUGGGGA-ACGCCCCGGAUUGAAACAUCUUAGUAGGG --GCAGGAAGAGAAAGCGAAU-GCGAUGUCGUUAGU-AAC-CGCGAGUGAACGCGA-CAC AGUCCAAA-CCGAAGCCUU------------------CGG--GCAAUGUGGUGUUC---- -----------------------------GGACUGACU---------------------- ------CCCAUC-------AGC----AG----AACGUUUCC------GAG-AAGUC-UCC UG-GA-------ACGGA------G-CGCG-AUACAGGGUGACAGCCCCGUAUCGGAA--G -CAAGU-AU---------G-------CUGUGCGUCAGCUCCAGAGUAGCGGGGAUU---G GAAAUUCCUCGUGAAUUCGGCAGACAUC-GUCUGCCAAGACUAAAUACGU--CC-UGAGA CCGAUAGC-GAACAA-GUAGCGUGAGCGAACGCUGAAA-AGCAC-CCCGAGAAGGGAGGU GCAAUAGGGCUUGAAAUCAGAUGGCGA-UCG-AGCGA-CGGGGCACAAAAGGU-CACU-- UGGAAAA-----------------------------------CGACCGAGG--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGAGCCUCCAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UAGGACCCA-AGUGAA--GCCGGUGUUCCGUCGUACGUUUUGAAAAACGAACCAG GGAGUGUA-U----UUGUUUGGCGA---GUCUAA-CCC--G-U---------UCA----- -------UCGGG-G-A-A-GGCGUAGGGAA-ACCGACA--------UGGCCGC----AGC ---------AUU-------GC-C----AGGGC-CGC---------------------CGU GU----------------------------------------UCAA-------------- ---------------------------------------------GCGCG---------- ----------------------------------------GG------------------ ------------------------GAGUCAAACGGAUAC-GACCCGAAACCGG-GUGAUC UAUGCGUGGACAGGACGAAGCGUGG-CGAAAGC-UACGUGGAGGUCCGUU-AGAG-UUGG UGUCCUACAAUACCCUCUCGUGAUCUACGUAUAGGGGUGAAAGGCCCAUCGAACCCGG-A AACAGCUGGUUCCGACCGAAACAUGUCGAAGCAUGACCUCUGC-C--------------- ------------------------------------------------------------ -------------------GAGGU-AG-UCCGUGGGGUAGAGAGACUGAUUGGA-GGC-C CC-GC-CCC-C-GAGA--GGGGUC-GGACCUCCUGUCAAACUCCGAACUCACG-GA--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-GG--AC--G-CAGGG-AGU-CCG-CUG--UG-CGGGG-UAAGCCUGUG-CA -GCAUGA-GGGAG----ACA--ACCCAGAGCUG--GGUUAAG--GUCCC--CAAGUG--U G-G-AC-U-AAG--UGCGA-UU-----G--AAGGUAGUCCCGAGCCCUAGACAGCCGGGA GGUGAGCUUAG-AAGCAGCUAC-CCUCUAAGAAAAGCGUAACAGCUUACCGGCC-----G AGGUUCGGGGCGCCCAAAAUG-AUCGGGGCUC-A-AGUCC---ACC--------ACC--G AGA-CCUAGCG--GCA---C--G----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------CUUAC----------------------------- --------------------------------AGC-G-UGGUUC-CG--UAGGU----CG ---G-CACU-CCGGU-UG------------------GG-U-------------------- ------------------------------------------------------------ ---------------------------------------------------------GGA AGCAC-G--G-ACGA-GA-GUU--CGUG-U-GGA-CCGACU-G--GUGAAGAUAAUCC-U GGUUG-CAGUA-GCAGC-GAUA-GUCGG-G------------------UGUGAAU----- ----------CCUGAC-GGCC-UAA-UGAGC-AAGGGUUCCU-CGGCAAUGUUUGUCAGC CGAGGG------------UUAGCCGG-UC-C-UAA----GACU-C-GUCGUAA-UUCGAG C--------------------------G-A-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA-AGUGGGA-AAC-UGG--U UAA----UAUU-CCA----GUGCC-A-CU-A--UGCA----------------------- ----------------------------------------------------------UU GAAC-------------------------------------------------------- --------------------------------------------GC-CG-AC--GCCU-U GGGGUC--GA--C-CGAAC-C-GGG--C------CUUC-----G---CC-CGGU--CG-- -A------ACU------GU-C------C------A--------A---A-----U--CCGU G-G------A----A-G--C--C-----G--UAA-U-GGC-ACGAA-GC--GG----A-C -G--A--ACGG-C--A--G-G--A-UA-G-C----------------------------- ---------GC-AA----------------------------------------GU---- CG-G----UU--CAAC-C-UG-G-GGCC-CGUGAAA-A-G-GC----------------- ------------------------------------------------------------ -----AAG-CAU--AG-U-GUCCGUACCGAGAUCCGACACAGGUGCUCAUGCC-GGCGAA -A-GGCAAGG-CCUGU-CGGGAUCAACCGA-CGUUAGGGAAUUCGGCAAUC-UGGCCCCG UAAGUUCGCG-AUAAGGGGUGC-CU-GC--C-UC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G GA-AA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G--A-GGCAG-GUCGCAGUGACUCGGACGCUCCGA-----CUGUCUAG UAACAACAUAGGUGACCGC-AAAUCC--GC---A-A------------GGACUC-GU-AC GGUCACUG-AAUCCUGCCCAGUGC-G-GGUAUCUGAAC-ACCUCG------------UAC A--------------AGAGGA-CGAAGGACCC-G-UCAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAGUACCUUGCCGCU-UCAGUAGCGGCUUGCAUGAAUGGAUUAACG AG-A--GCGUC--GCUGUCCCAA-CG-UUG-GGCCCGGUGAACCAUACGU-UCCAGUGCG GAGUCUGGAGACACCCAGGGGGAAGCGAAGA-CCCUAUGGAGC-UUUACUGCAGGCUGUC GCUGGGACAUGGUCGCUGAUGUGCAGGAU-AGGUAGGAG-ACGUUAC-ACA--GGU-GCG UGC--------------------------------------------------------- ----------------------------------GCCA--GCACGUCGCC-GAGU--CA- ACAC-UGAAAUA-CUACCCGUCAGUG-ACUGUGACCCUCA-CUC-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GGGA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGGA -CAC-CGAUAGCCGGGCAGUUUGACUGGGGCGGUACGCGCUCGA-AACAAUAUC-GAGCG CGCCCUAAGUCCAUCUCAGUCGGGUCGGAGACCCGACGAA-GAGUGC-AAGAGCAAAA-G AUGGAUUGACAG-UGUUCUUCCCAAC-G-AGGAACGCUGACGCGAAAGCGUGGUCU-AGC G-AACCGAUG------------------------AG---------C-CUGC--CC-GAU- ----------------------------GCGGGCCAUUGAUGA-CAG--AAAAGCUACCC UAGGGA-UAACAGAGUCGUCACUCGCAAGAGCACAUAUCGACCGAGUGGCUUGCUACCUC GAUGUCGGUUCCCUCCAUCCUGCCCGUGCAGAAGCGGGCAAGGGUGAGGUUGUUCGCCUA UUAAAGGAGGUCGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGCUGCUAUCUACUG --GGU--G-UGU------------------------------------------------ -----CUGACGC-UUGACAGGAAC-AACCGUAUAGUACGAGAGGAACUACGGUUGGGUGC CAC-UGGUUUA-CCGGU-UGUCC-GAGA-GGGC-AC--UGCCGGGCAGCUA-C-GCACCA -CA-GGGUAACGGCUGAAUGCAUC--U-AAGCCGGAAACC------UAC-CUGGAAA--- --AGAAGCG---------------------------UC--G------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CC------------------------------ ------------------G---AGGUC---UCUC--G-UAGAAGACGA-GU-UCGAUAGA CUUGG-GGUGUACG-CGU-CGAG----------------------GCAA-------C--G -AGACGU--U--CAGCC-----CGCG----A-GUACUAA-CAGACC-GAA----G-CCAC -CA----- >Picrophilus_torridus ------AUUGUGUACUGCUAAACUGUCU-GGGGGAUG-GUU-UGGCU-UGA-G--AGC-C GAAGAAGGACGUGCC-AAGCUGCGAAAUGCUCUGGGGAGGCGCAUG-GA-GCCUUA-GAU CCAGAGAUCUCCGAAUGGGACU-UCCU--------------------------------- -------------GAU-------------------------------------------- --------------------------------------------------------UC-- ACUCCG------------------------------------------------------ -----------------UAA-GGAGAGGGC-ACCCCGGGAAUCGAAACAUCCUAGUACCG --GGAGGAAAAGAAAUCAAUC-GAGAUACCGUGAGU-AAA-GGCGAUCGAAAGCGG-UAG AGGGCAAA-CCGAAUCCUACCC---GA----AAGGGCAAG--GAGAUGUGGAGUAU---- ----------------------------GGACUUU----CCC------------C----- ------AA-----------CGC--CUCU----UUUAUCGAU------UCG-A-AUA-AGC UG-GG-------AAGCU------U-AGCC-AUAGAGGGUGAUAGCCCCGUAGAAGAAGAU -A-AAA-AG---------GCC----AUGAGGGGAAGUAUCCUGAGUACCAUGCGUC---G UUAUUCGCGUGGGAAUACGGGUGGCAUG-AACAUCCAACCCUAAAUACAU--CU-CAAGU CCGAUAGC-GAAC-AAGUACCGUGAGGGAAAACUGAAA-AGCAA-CCCGG-AAGGGCUGU GAAA-AGAGCCUGAAACCAGACAGUGA-AAA-CUUUA-UAGGGCACUAAAGGG-GU---- -------------------------------------------GAACC------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GAAAG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GUG---ACCGGUGUCCUAUAGUCCGUGUUGAAGAACGGGCCAG GGAGUUGC-G----ACGGUUGGCAA---GGCUAA-UUC--U-----------UAA----- --------AGAA-G-G-A-GCCGUAGCGAA-AGCGAU---------UACCCGC---ACA- --------GCAA--------U-G--G-AGGGG-UAG---------------------CGU AC----------------------------------------CCAA-------------- ---------------------------------------------GUGCG---------- ----------------------------------------UU------------------ ------------------------UAGUCAGCCGUGGCA-GACCCGAAGCCGC-UCGAUC UACGCCUGAGUAGGUUGAAGCUUAG-CGAAAGC-UAGGUGGAGGACCGA--ACCG-GUUC UGAUGUGCAAAUCGUUCGGAUGACUUGGGUGUAGGGGUUAAAGGCUAAUCUAGAGCGG-C AAUAGCGGGUUCCCCCCGAAACUACCCGCAGGUAGACCUCCAU-G--------------- ------------------------------------------------------------ -------------------GAGAU-UU-CGGAUGAGGUAGAGCGACCGAUUGGC-CGG-U UA-GU-AGU-C-GAAA--GACUGC-GCCG-GCCUAUCAAACUCCGAACUUGUC-CG--A- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--A-UGGGG-UGC-UAG-GGC--AU-AGGGA-UAAGCUUUAU-GC -CCGUGA-AGGGA----ACA--ACCUAGACCUG--GAUUAAG--GCCUC--UAAAUA--C U-G-GC-U-AAG--UGCGAU-C--U--A--AAAAG-GUUUGCGGCCGAAGACAGUGGGGA GGUUGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUGCGUAACAGCUCACUCACC-----G AGGCUACAUGCCUUGAAGAUG-GAAGAGGCUA-A-AGCCA---GUU--------GCC--G AGA-UCCAGGA--C-C---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ---------------------------------GG-U-GAU-GU-GG--UAGGG----GG ---G-CGUG-CUGU-AUG------------------GG-A-------------------- ------------------------------------------------------------ ---------------------------------------------------------CGA AGCUU-C--U-UCGA-GA-GGA--GGAG-U-GGA-CCGUAC-A--GUAUCGCGGAUCC-U GGUAA-AAGUA-GCAGU-CA-A-GAGUG-G------------------UGAGAAU----- ----------CCACUC-CGCC-GAA-AGGGC-AAAGGUUCCU-UGGCAAUGUUCGUCAGC CGAGGG------------UUAGCCGA-UC-C-UAA----GGCC-A-UUCCUAA-CAGGAA A--------------------------U-G-G---------------------------- ------------------------------------------------------------ ----------------------------------UC---GA-AA-GGGA-AGC-UGG--U UAA----UAUU-CCA----GCGCC-U-GA-G--GUGU----------------------- -----------------------------------------------------------U CU---------------------------------------------------------- -----------------------------------GCCAUGC-AUG-UG-A---GCUU-C GGGAUA--GG--A-GGAGC-A-CAC--C------CGUC-----A---GU-GUGU--UG-- -G------UGC------AU-A------U------A--------A---G-----C--AGAU G-G------A---GA-G--U--U-----G--UAA-U-GAC-GUAAA-GU--CU----G-C -G--A--AGAU-G--U--A-U--C-UG-U-CCC-C------------------------- ---------UU-AU-----------------------------------GGG--GAUU-- UC-U----CU-AAUUC-C-UG-G-AGCC-CAUGAAA-A-G-CAUG---C--A-UGG-GUC ------------------------------------------------------------ -----A-A-GCC--CC-A-GAUCGUACCAAGAACCGACACAGGUGCCCCUGGA-UGAGAA -G-UCCAAGG-CGUUU-GGGAA-UAAUGGA-CGCGAGGGAACUCGGCCAAA-UAGCUCCG UAUCUUAGGU-AGAAGGAGUGC-CU-AU--C-CA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G AG-AG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------A--G-GAUAG-GUCGCAGUGGCAAGGGGACCCCGA-----CUGUUUAC CAAAAACACAGAUCACUGC-UAGUCC--GU---A-A------------GGAUGU-GU-AU AGUGGUCG-AAACCUGCCCAGUGC-U-GGUACCUGAAA-GCUCCG------------CUC A--------------AGGAGA-AGAAGGGCCA-G-UAAACGG-CGGGGGUAACUAUGACC CUCUCAAGGUAGCGUAAUACCUAGCCGCU-UAAUUGGCGGCUUGCAUGAA-GGUUCAACG AG-A--GUCCC--ACUGUCCCCG-CG-UUC-AGCCCCGUGAAAUUAAUGU-ACUGGUGCA CAAUCCAGUCUCUCCCACGUGAAAGCGAAGU-CCCCGUGGAGC-UUUACUGCAGCCUGUA GCUGUGACGCGAUUCUCAAUGCGUAGGGU-AGGAAGGAG-CCAU--C-GAA--GUU--CC GGU--------------------------------------------------------- ----------------------------------UGUG--GCCGG--AAUGGAGG--CG- ACGA-UGAAACA-CUUCCCUUUGGGA-GUUGCGUCACUAA-CCU-U-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GCAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-AGGGA -CAA-CUAUUGGUGGGCAGUUUGGGUGGGGCGCCACGCCUCUAA-CAAUCCAAC-AGAGG CCUCCAAAGGUCAGCUCAGGAGGGUCAGAAAUCCUCCGUA-GAGUAU-AAAGGCAAAA-G CUGGCUUGACAG-UGUUCCAGACAA--UAAGGAACGCUGAUGCGAAAGCAGGGCUU-AGC G-AACCACCU------------------------UG--------UCUCCCU-CUU-CAU- ----------------------------GAGGGCAGGUGAUAA-GAG--AGAAGUUACCC CAGGGA-UAACUGAGUUGUCCUCGGCAAGAGUACACAUCGACCCGAGGGUUUGCUACUUC GAUGUCGUCUGUUCCUAUCCUGGCGCUGCAUAAGACGCCAAGGGUGGGGCUGUUCGCCCA UUAAAAGGGAUCCUGAGAUGGGUUCACUACGUCGCGAGACAGUAGGGUUGCUUCUCCGUG --GGA--G-UGC------------------------------------------------ -----UCGAUGC-CUGAAGGGAAG-GAGCCUUUAGUACGAGAGGAACGGGGGUUCGUGGC CUC-UGGUUUA-CCGGU-UGUCC-GACA-GGGCAGU--UGCCGGGUAGCUA-C-GCCAUA CGC-GAAUAAAGGCUGAAAGCAUC--U-AAGCCUGAAGUC------GCC-CCUGAAA--- --AGAGGCA---------------------------UC--GU------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UAU----------------------------- ------------------C---AGGUC---CCUC--C-UAAAAGAGGA-GC-UUGAUAGG ACCGG-GAUGUAAG-UGC-UGAGC---------------------UUUU------GC--G -AGGCAU--U--AAGUC-----CACG----G-UUACUAA-AAGACC-G------------ -------- >Pyrobaculum_calidifontis -------CUCCGCACGGCAAAGCCGCCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GAAGAAGGGCGUGGC-AAGCUGCGAUAAGCCCGGGGUAGCCGCAGG-CA-GGCUUA-GAA CCCGGGAUCCCCGAAUGGGGCU-UCCU--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------GG-------------GCC-G AAUAGGCCCC-----GGC-------------GCCCCG-U--------------------- ------------------AA-GGGGCGGGA-ACGCGGGGAAAGGAAACAUCUUAGUACCC --GCAGGAAGGGAAGCCAACA-GGGACCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAU AGCCCAAA-CCAAAUCCUCGCGG--GAC---AACCGUGGG--GAGAUGUGGGGCUU---- ----------------------------GGGCCCG---GGC------------------- ----------------AACCGC--CGGC----GGGCGGUAG------CCG-AAGUG-GGC UG-GA-------AUGCC------C-CGCC-GUAGAGGGUGAUAGCCCCGUAGGCGAAACC -GCCCG-UG---------GCG-----GAGUCCCGGGGUCCCGGAGUACCUCGGCUU---A GUUUUGCCGGGGGAACGCGCCGGCCACU-GGCCGGCAAGGCUAAGCACGU--CC-CGAGU CCGAUAGC-GCACUA-GUACCGUGAGGGAAAGCUGAAA-AGAAC-CCCGGAAGG-GGGGU GAAA-AGAGCCUGAAACCGGGCGGCUA-CAG-UGGGG-CAGGCCCGAAAGGAU-GCCCCC UCCCGAA-----------------------------------GGAAACCCC--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUGACGGGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGA-GGGGG---UCCAGGGUCUGCCCUUACGUCUAGAAACACGGGCCGG GGAGUUCA-C----GGCCGUGGCGA---GCCUAA-GGG--G-U---------UCAA---- --------CCCC-G-G-A-GGCGUAGGGAAA-CCGAC---------AGCCCGC----AGC GGGG------CA---ACCCGC-G----AGGGG-CGG---------------------GGU CU----------------------------------------UAAA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------UAGUCACGGCCGUGA-GACCAGAAACCGG-GCGAUC UAGCCCUGGGCAGGGUGAAGCGGGG-CGAAAGC-CCCGUGGAGGCCCGA--AGGG-GUUC UGAUGUGCAAAUCGUUCCCAUGACCUGGGGCUAGGGGCAAAAGACCAAUCAAGCCCGG-U GAUAGCUGGUUCCCCCCGAAGCGGGUCUCAGCCCGGCCUCCCC-G--------------- ------------------------------------------------------------ -------------------GAGGC-GG-CCGGCGGGGUAGAGU-ACUGAUCGGG--GG-U GCGGG-AGC-C-GAAA--GGCUCC-GGCC-CCCGGUCAAACUCCGAACCUGCC-AG--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AA--G-GGGGG-AGG-CGG-GGG--CG-GUGGGGUAAGCCUCCG-CU -CCGAGA-CGGGA----ACA--ACCGAGACCGG--GGUUAAG--GCCCC--CAAGUG--C G-G-GC-U-UAG--UGUCAA-UCUA--A--AAGGGCGUCCCCCGCCCAAGACAGCGGGGC CGUGGGCCUAA-CAGCAGCCAU-CGGCUAAGCAACGCGUAACAGCGGACCCGCC-----G AGGCGGGGGGCCCCGAAGAUGUACAGGGACU--A-AGCCC---GCC--------GCC--G AGA-CCCCGGC--C-C---G--C----GG-G---------------CC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUU------------------------------ ----------------G----G---------CCCG-C-GU--GG-GG--UAGGG----GG ---G-CGCG-GCCG-UG-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGCCG-G--G-CCGU-GA-GGU--CCGG-U-GGA-CCCGCG-G--CCGACGAAGAUCC-C GGCGG-UAGUA-GCAGC-G-AA-GAGGG-G------------------UGAGAAG----- ----------CCCCUC-CGCC-GGAAAGGAC-CAGGGUUUCC-UGGCAACUUCAAUAGGC CAGGAG------------UUAGCCGG-UC-C-UAA----GGCG-G-GGCCUAA-UAGGCA C--------------------------C-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUGCC-G-CG-G--GGGU-A-G--G-UUCU-G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------GG-CCCCGU-CCC-CG-AC--GCCU-C GGGAUA--GG--G-CGGGC-G-GGA--C-----UGCC------G---UC-CCGC--UU-- -A------ACC------GU-C------G------A--------A---G-----G--CCGG G-G------A---GU-G--C--C-----G--UAA-U-GGC-GAGAA-CC--GG----C-C -G--A--AGGC-G--G--G-A--A-UA-G-CCG-GGG----------------------- ---------GU-UU--------------------------------CC-CCG--GUC--- CG-C----CC-GACUC-C-UG-G-GGCC-CGUGAAA-A-G-GGGA---C--G-GGG-AA- ------------------------------------------------------------ -C--GAGC-CCC--CG-C-GCCCGUACCGAGAACCGACGCAGGUGCUCCUGGG-UGAGAA -G-CCCAAGG-CGGCU-CGGG-UGACCCCG-GGCCAGGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAGGGCGCGG-CG-GA--G-GA-UUUAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------U-C----- C-----CGA-G----G-GGCAG-GUCGCAGUGGCAAGGGGGACCUGA-----CUGUUUAA CAAAAACAUAGGUCCCCGC-GAGCCC--GU---A-A------------GGGUGU-GU-AC GGGGGCUG-AAUCCUGGCCACUGG-C-GGUACGUGAAC-CCCGGG------------UAC A--------------ACCGGG-CGAAGCGCCG-C-UGAAGGC-CGGGGGUAACUCUGACC CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGGGCCGGCGUGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCCGG-CC-CGG-GGCCCGGCGAACCCAC-CU-CCAGGUGCA CAGUCCUGGGACCCCCGACGGGGCGAGAAGU-CCCUAUGGAGC-UUCACAGCAGCCUGUC GUUGCGGGGGGGCGGGGGGUGCAGAGCGU-AGGUGGGAG-CGAU----GAA--ACG--GG GUC--------------------------------------------------------- ----------------------------------UCCG--GGCCC--CGUGGAUG--CG- ACCC-UGGAACA-CCACCCACUCUCC-GCCCCUCCGCUUA-CCC-G--CC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-CAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GGC-GGGGA -CAG-CGGCAGGCGGGCUGUUCGGCUGGGGCGGCACACCCCUGA-AAAGAUAUC-GGGGG UGCCCAAAGCUCGGCUCAGGCGGGUCAGAAAUCCGCCGUA-GAGUGU-AAGGGCAAAA-G CCGGGCUGACUG-GGCCCUUGAAC--GCAAGGGGCCCAGGCGGGAAACCGGGGCCU-AGA G-AACGCUCG------------------------UG---------C-CCCC-ACC-AGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC UAGGAA-UAACCGGCUCGUCGCGGGUGAGAGUCCCCAUCGACCCCGCGGUUUGGUACCCA GACGUCGUCUCUUCCCAUCCUGGCGGUGCAGCAGCCGCCAAGGGUGGGGCUGCCCGCCCA UUAAAGGGGAACGUGAGAUGGGUUCAGACCGUCGCGAGACAGGUCGGUCUCUACCUGUCG --GGG--G-CGC------------------------------------------------ -----UGGCCGC-CUGAGGGGAAG-GUGCCCUCAGUACGAGAGGAACGGGGCGCCGCGGC CUC-UAGUGUA-CCGGU-UGUCC-GGCA-GGGC-AC--UGCCGGGCAGCCA-C-GCCGUG -GG-GGAUAACCGCUGAAAGCAUC--U-AAGCGGGAAGCC------CGU--AGAAGA--- --CGGGGUU---------------------------GA--GGG--------GG-G--C-- G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUGU----------------------------- ----------AACC-CCCG---AGGGU---UUCCC-G----------------------- -AGGG----------------------------------------GAGA----------- ------------GCCGG-----CCCC-------UCCCAA-UCGCCC-GA----------- -------- >Pyrococcus_furiosus --------CU-AGGACGCUAAGCCGCCC-GGUGGAUG-GCU-CGGCU-CGGGG--CGC-C GACGAAGGGCGUGGC-AAGCUGCGAUAAGCCCCGGCGAGGCGCAGG-CA-GCCGUC-GAA CCGGGGAUUCCCGAAUGGGACC-UCCC--------------------------------- -------------GCGG------------------------------------------- ----------------------------------------CU-------------UAU-G CCGCACUCCG-------------------------------GGGUUUA------------ ---------------UCCCC-GGAGGGGGA-ACGCGGGGAAUUGAAACAUCUUAGUACCC --GCAGGAAAAGAAAGCAAAA-GCGAUGCCGUGAGU-AGG-GGCGACCGAAAACGG-CAG AGGGCAAA-CUGAACCCCGGGCC--GAC---GAGGUUCGG--GGGAUGUGGGGUUG---- ----------------------------UAGGGCC----CCC-----------GU----- ------AUGAGAC-----CCUC-----G----CGGGUGAAG------CCG-AAGUC-CGC UG-GA-------ACGCG------G-CGCC-GGAGAGGGUGAUAGCCCCGUAGGCGUAAGC -C-CGC-AG---------GGU-----CUCG---GGGGACCCUGAGUACCGUCGGUU---G GAUAUCCGGCGGGAAGCUGGGAGGCAUC-GGCUCCCAACCCUAAAUACGU--CC-CGAGA CCGAUAGC-GAACUA-GUACCGUGAGGGAAAGCUGAAA-AGCAC-CCCGG-GAGGGGGGU GAAA-AGAGCCUGAAACCGGGCGGCGA-UAG-GAGGG-UGCGGCCCGAAAGGAAUGAGCC UCCCCGAA----------------------------------GGAAACCGC--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACGCGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG-AGGGG---ACCGGGGUUGCACCGUCCGUCUUGAAACACGGGGCAG GGAGUUCG-C----GGCCGUGGCGA---GGUUAA-GGG--G----------GUUAAG--- --------CCCC-G-U-A-GCCGCAGGGAA-ACCGACA--------UGCCCGC----AGC CGGGC---UUAU--GCCCGGU-G----AGGGG-CGG---------------------GGU GC----------------------------------------GAAA-------------- ---------------------------------------------GCGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACGGCCGCGA-GACCCGAAACCGG-UCGAUC UAGCCCGGGGCAGGGUGAAGUCCCU-CAACCGA-GGGAUGGAGGCCCGCU-AGGG-GUGC UGAUGUGCAGUUCGCUCCCGUGACCCCGGGCUAGGGGUGAAAGGCCAAUCGAGGCCGG-A GAUAGCUGGUUCCCGCCGAAUCAUCCCGCAGGAUGGCCUCCCC-G--------------- ------------------------------------------------------------ -------------------GAGGU-AG-GCGGUGGGGUAGAGC-ACUGAUUGGA-GGU-G CA-GG-GGG-C-GAAA--GCCCCC-GGCC-UCCUGUCAAACUCCGAACCCACC-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-GGGGG-AGU-AGG-GUG--G--CGGUG-UAA-GCCGUC-CA -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--AAAGUG--C C-G-GC-U-AAG--UGUUA--CUCC--A--AAGGGUGUCCCGGGCCUUAGACAGCGGGGA GGUAGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUGCGUAACAGCUCACCCGUC-----G AGGUCCGGGGCCCCGAAAAUG-GACGGGGCUC-A-AGCCG---GCC--------GCC--G AGA-CCCCGGC--G-C---A--C----GG-A---------------CC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAUU----------------------------- ----------------G----G---------UCCG-U-GAU-CG-GG--UAGGC----GG ---G-CGUG-CCGG-UG-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGCCG-G--G-CCGU-AA-GGU--CCGG-U-GGA-GCCGCC-G--GUAUCGCGGAUCC-U GCCGG-GAGUA-GCAGC-G-UA-GUCGG-G------------------UGAGAAU----- ----------CCCGAC-CGCC-GGA-GGGGC-CAGGGUUCCA-CGGCAAUGGUCGUCAGC CGUGGG------------UUAGUCGG-UC-C-UAA----CCCC-G-CCCGUAA-CUCGGC G--------------------------C-G-G---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AA-GGGA-AAC-GGG--U UUA----UAUU-CCC----GUACC-G-CG-G--GGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AG-CCCGGA-GGG-UG-AC--GCCU-C GGGGUA--GG--C-GGACC-G-GCC--G-----AUG-------A---GG-CCGG--CU-- -A------AGC------GU-A------U------A--------A---G-----C--CCGG G-G------A---GU-G--C--C-----G--UAA-U-GGC-GAGAA-CC--GG----G-U -G--A--AAGC-G--C--G-A--A-UG-G-CCC-CCCC---------------------- ---------GU-UA--------------------------------GG-GGG--GUU--- CC-G----CC-GAUCC-C-UG-G-GGCC-CGUGAAA-A-G-CCCU---C--C-GGG-AA- UUC--------------------------------------------------------- -C--GAUC-CCC--CG-C-GACCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAGAA -G-CCUAAGG-CGUGU-CGGGGGAAACCCG-GCCGAGGGAACUCGGCAAAC-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-GC--G-GG-U------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-UA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------A-C--C-CGCAG-GUCGCAGUGACUAGGGGGGCCCGA-----CUGUUUAA UAAAAACACAGGUCCCAGC-UAGCCC--GA---A-A------------GGGUUU-GU-AC UGGGGCCG-ACGCCUGCCCAGUGC-C-GGUAUGUGAAG-CCCGGG------------UAC A--------------ACCGGG-UGAAGCACCG-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUUCCUUGUCGGU-UAAAUGCCGACCUGCAUGAAUGGCGUAACG AG-G--UCCCC--GCUGUCCCCG-GC-CGG-GGCCCGGCGAAACCUCUG--CCUGGCGCG CAUGCCAGGGACCCCCGGUGGGAAGCGAAGA-CCCCAUGGAGC-UUUACUGCAGCCUGCC GUUGCCACACGGCGGGGGGUGCGCAGCGU-AGGCGGGAG-GCGU--C-GAA--GCC--CG GCC--------------------------------------------------------- ----------------------------------UCCG--GGUCG--GGUGGAGC--CG- UCCA-UGAGACA-CCGCCCACUCCCC-GCUGUGUGGCUAA-CCC-C--C----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-AAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GG-GGGGA -CAG-CGGUAGGUGGGCAGUUUGGCUGGGGCGGCACGCCUCCGA-AAAGGUAUC-GGAGG CGCCCUAAGGUCGGCUCAGGCGGGUCAGGAAUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACUG-GACCCGUAACAG-AGG-CGGGUCCAGCCCCGAAAGGGUGGCCU-AGC G-AACCCCUG------------------------UG---------C-CUCC--CC-GGU- ----------------------------GGGGGCCAGGGAUGA-CAG--AAAAGCUACCC UGGGGA-UAACAGAGUCGUCUCGGGCGAGAGCCCAUAUCGACCCCGAGGCUUGCUACCUC GCUGUCGGCUCUUCCCAUCCUGGCCCUGCAGCAGGGGCCAAGGGUGGGGGUGUUCACCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGAUGCUAUCUACCG --GGG--G-UGU------------------------------------------------ -----UGGCCGC-CUGAGGGGAAG-GUGCCCCUAGUACGAGAGGAACAGGGUGCCGCGGC CUC-UGGUCUA-CCGGU-UGUCC-UCCC-GGGC-AU-C-GCCGGGCAGCUA-C-GCCGCA -GC-CGAUAAGGCCUGAAAGCAUC--U-AAGGCCGAAGCG------GCC-CCCGAAA--- --AUAGGCG---------------------------GC--CGU--------UC-C--C-- U-GGCG-C-UUGGGCCU-GG---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCGA-----------------------CCGGCC CAUUGC-CA-GGGA--C-G---AGGGC---UCGG--G-UAGAAGACCC-GG-UUGAUAGG GCGGG-GAUGUAAG-CGG-GAAGG---------------------GUCAA-----CC--G -ACCCGC--U--UAGUC-----CGCC----G-CCCCUAA-UCGCCC-GA-----G-GUCC -U-GCC-- >Staphylothermus_marinus ----------------CCGACGCCGCCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GAGGAAGGCCGUGGC-AAGCUGCGAUAAGCCCGGGGUAGGCGCAUG-CA-GCCGUU-GAA CCCGGGAUCGCCGAAUGGGACC-UCCU--------------------------------- -------------GCCA------------------------------------------- ----------------------------------------CG-------------GGC-G AAGAGCCCGU-----GGC-------------GUCCGG-G-AAACCGGGAUGGG------- ---------------AGUAC-CGGACGGGA-ACCCCCCGAACGGAAACAUCUUAGUAGGG --GGAGGAGGAGAAACCACCACGGGAUCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAG AGCCCAAA-CCAAUCCUCCACGG--GAU---AACCGUGGA--GGGAUGAGGGGUUG---- ----------------------------AUGGGUCUCCGGCGG--------GGC------ ------UUGAGCCCCAGAGGGC--CUAU----CCACGGUAG------CCG-AAGUG-GCC UG-GA-------AUGGC------C-CGCC-GUAGAGGGUGAAAGCCCCGUAGGCUAAACC --GUGG-AG---------GCC-----CUCGCCGG--AGACCAGAGUACCACGGCUU---G GUUUUGCCGUGGGAAGCCGGGAGGCACC-GGCUUCCAAGGCUAAAUACGU--CC-CGAGA CCGAUAGC-GUACUAAGUACCGUGAGGGAAAGCUGAAA-AGUAC-CCUGGAAAG-GGGGU GAAA-AGAGCCUGAAACCGGGCGGCUA-CAU-ACGGC-GCAGCCUGGAAGAGAUGAGGUC CUCCAAA-----------------------------------GGAAACCGG--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACCCGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGAG-GACUG---AUCAGGGUUGCGCCGUCCGUCUUGAAACACGGGCCGG GGAGUCCA-C----GGCAGUGGCGA---GCCUAA-GGG--G----------GACAAAG-- --------CCCC-G-U-A-GGCGUAGGGAAA-CCGACA--------AGCCCGC----AAC CGGGC---GCAA---GGC-GU-G----AGGGG-CGG---------------------GGU CC----------------------------------------UCAUA------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCACUGCCGUGG-GACCAGAAACCGG-GCGAUC UAGGCGGGGGCAGGGUGAAGCCGGG-GGAAACC-CCGGUGGAGGCCCGCA-AGGG--UUC UGACGUGCAAUUCGUUCCCCUGACCCCCGUCUAGGGGCAAAAGACCAAUCUAGCCCGG-U GAUAGCUGGUUCCCGCCGAAGUGGCUCUCAGGCCAGCCCCGCC-A--------------- ------------------------------------------------------------ -------------------GAGGC-UG-GCUACGGGGUAGAGCUACGGAUUGGG--GG-U GCAGG-GGG-C-GAAA--GCCCCC-GGCC-CCCUAUCCAACUCCGAACCCGUG-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGC-AG--AA--G-GCGGG-AGU-GGGGCUC--CC-CGGGG-UAAGCCCGGG-GG -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--AAAGUG--C C-G-GC-U-AAG--UGCCAA-GCCC--A--AAGGGCGUCCCGCGGCUUAGACAGCGGGGA GGUGGGCCUAA-CAGCAGCCAU-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGCCGCGGGGCCCCGAAGAUUGGUCGGGGCUC-A-AGCCG---GCC--------GCC--G AGA-CCCCGGG--G-C---A--C----GG-C---------------UC-C---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAU------------------------------ ---------------GG----A---------GCCG-U-GAU-CC-GG--UAGGC----GG ---G-CGCC-GGGU-CG-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGCCG-G--G-CCGA-GA-GGU--CCGG-U-GGA-CCCGAU-C--CGGGUGUGGAUCC-C GGCGG-CAGUA-GCAGC-G-AA-GAGGG-G------------------UGGAAAU----- ----------CCCCUC-CGCC-GGAAAGGGC-CAGGGUUCCU-CGGCAACGGUCGUCGGC CGAGGG------------UUAGCCGG-CC-C-UAA----CCCG-G-GCCGUAA-CACGGA C--------------------------C-C-G---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AG-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUGCC-G-CG-G--GGGU-A-G--A-C----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AG-CCCGGC-CUC-CG-AC--GCCU-C CGGAUA--GG--C-GGACC-G-GGG--GCACCCGAAU-GGGUGCG--AC-CCGG--CU-- -A------ACC------GG-U------G------A--------A---G-----G--CCCU G-G------A---GA-A--C--C-----G--UAA-U-GGU-GAGAA-GG--GG----C-C -G--A--AGCC-G--G--G-A--A-UG-G-GAC-CCC----------------------- ---------GU-AU--------------------------------GG-GGU--CUU--- CC-G----CU-GACUC-C-GG-G-GGCC-CAUGAAA-A-G-GGGG---C--C-GGG-AA- ------------------------------------------------------------ -C--GAUC-CCC--CG-C-GUCCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAGUA -G-CCCCAGG-CGUCU-GGGGGAUAACCCG-GGCCAGGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CC-GC--G-GU-CUGGAGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C AA-AA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------A-C----- C-----CUG-G-A--C-CGCGG-GUCGCAGUGCCUAGGGGGGCCUGA-----CUGUUUAA UAAAAACAUAGGUCCCCGC-AAGCCC--GA---A-A------------GGGUGU-GU-AC GGGGGCUG-AAUCCUGGCCACUGG-C-GGUCCGUGAAA-CCGGGG------------UAC A--------------ACCCGG-CGAAGCGCCG-C-UGAAGGC-CGGGAGUAACUCUGACU CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UGAGUUCCGGCGCGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCUGG-CC-CGG-GGCCCCGCGAAUACACGGA-GCCGGUGCA CAGGCCGGCAACCCCCCGCAGGGCGAUAAGA-CCCCGUGGAGC-UUCACCGCAGCCUGGC GUUGGCCUCCGGGCUGCGGCGCGUAGCGU-AGGUGGGAG-CC-AG-U-GAA--CCC--GC CCC--------------------------------------------------------- ----------------------------------UCCG--GGGGC--GGGGGAGG--CG- CCAA-UGAAACA-CCACCCACCGCAG-CCCGGAGGCCUUA-CCC-C--CG--------G- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAGAU ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------C-C-CGG-GGGGA -CAG-CGUCAGGUGGGCGGUUUGGCUGGGGCGGCACGCCCGCGA-AAAGGUAAC-ACGGG CGCCCAAAGGUCGGCUCAGGCGGGUCAGAGCUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCUUGACCG-GACCCCGGAAC--ACAACGGGUCCGGCCGGGAAACCGCGGCCU-AGC G-AACGCUCG------------------------UG---------C-CCCC-CUC-GGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC CGGGGA-UAACAGAGUCGUCGCGGGCGAGAGCUCCCAUCGACCCCGCGGUUUGCUACAUC GAUGUCGGCUCUUCCCAUCCUGGGAGUGCAGCAGCUCCCAAGGGUGGGGCUGCCCGCCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAG-UCGGACUCUACCCGCGG --GGG--G-UGU------------------------------------------------ -----GGGCCGC-CUGAGGGGAAG-GUGCCCUCAGUACGAGAGGAACGGGGCGCCGCGGC CAA-UGGUGUA-CCGGU-UGUCC-GGCA-GGGC-AU-A-GCCGGGCAGCCA-C-GCCGUA -GG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CUC-CCCGAAA--- --AGAGGCG---------------------------GC--CG---------UC-C--G-- C-CGAA-G-GG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUUU----------------------------- --CCUCUUC-GGCG--G-G---AGGGC---UCCC--G-UAGAAGACGG-GG-UUGAUGGG GCGGG-GGUGUAAG-CCC-CGAGGGA--GC---------------AUUG--UCUCCC--A -AGGGGU--U--UAGCC-----CGCC----G-CUCCCAA-AAGCCC-GA--C--G-CCGC -A------ >Sulfolobus_acidocaldarius ---------------GCCGAAGCCUCCC-GGUGGAUG-GCU-CGGCU-CGG-G--CAC-C GAAGAAGGGCGCGGC-AAGCAGCGAAAUGCUCGGGUGAGGCGCAAG-CA-GCCGUU-GAC CCCGAGGUCCCCUAAUGGGAUA-UCCU--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------GG-------------UUU-C CGGCGCUCCC-----GGU-------------UUAUAA-C--------------------- ------------------UG-GGAGUGGGA-ACCCCCCGAACGGAAACAUCUUAGUAGGG --GGAGGAAAAGAAAUCAAUU-GAGAUCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAC AGCCCAAA-CUAAACCUGCCGAU--GAU---AAGUCGGUG--GGGAUGUGGUGUUA---- ----------------------------C-GACCUCUAGCCUG--------AGGU----- ------UCGACCU-CGGCUUUC--CUAA----CCUAUCUAG------CCG-AACUC-CCC UG-GA-------ACGGG------G-GGCC-AUAGAGGGUGAAAGCCCCGUAGGCUAAAGA --UAGG-UG---------GAA-----AGUGGCUA--GAGGUAGAGUACCAUCCCCU---G GUUUGGGGGUGGGAAGUUAGGGGACACG-UGCCUCUAAGGCUAAAUAUGU--CC-CGAGA CCGAUAGC-AAACUAAGUACCGUGAGGGAAAGCUGAAA-AGAAC-CCCGGAAGGGGGAGU GCAA-AGAGCCUGAAACCGGGUGGUUA-UAC-AGGGU-GUGGCUCGAAAGAAGUGAACCC UUCCGAA-----------------------------------GGAAAGGGG--C------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCAAGCCCUUAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGAA-GGGCGA--UCGG-GGUCACGCCUUUCGUCUUGAAACACGGGCCGG GGAGUUCA-C----AUCAGUGGCGA---GCUUAA-GGA--G----------AUUAU---- --------CUCC-G-A-A-GGCAUAGGGAAA-CCAAG---------UGCCCGC----AGC CUAG----UUU----CUAGGC-G----AGGGG-CAG---------------------GGU CU----------------------------------------GUCA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------UG------------------ ------------------------AAGCCACUGAUGUGA-GGCUAGAAACCGG-GCGAUC UAGUCCGGGGCAGGCUGAAGGUGGG-GGAAACC-CCACUGGAGGGCCGAAUAGGG-GUUC UGACGUGCAAUUCGUUCCCUUGACCUCGGACUAGGGGCAAAAGACCAAUCUAGCCCGG-U GAUAGCUAGUUCCCCCCGAAAUGCGUCCUAGCGCAGCCUCCCU-A--------------- ------------------------------------------------------------ -------------------AAGGC-AG-CUCGCGGGGUAGAGUGACAGAUCGGG--GG-C UC--C-AGG-C-GAAA--GCCUGG-GGCU-UCCGGUCUAACUCCGAACCCACG-AG--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGA-AG--AA--G-GGGGG-AGU-GGG-UCA--CU-CGGCG-UAAGGUUGGG-UG -GCAAAA-GGGGA----ACA--ACCCAGACCUG--GGUUAAG--GCCCC--AAAGUC--C C-G-GC-U-AAG--UGCCAA-CG----A--AAAGGCGUCUCCAGCCUUAGACAGCGGGAA GGUGGGCCCAG-CAGCAGCCAU-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGGCUGGAGGCCCUAAAGAUUGGUCGGGGCUC-A-AGCCG---GGC--------GCC--G AGA-CCCAGGA--GGG---G--G----U--C---------------UC-U---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ACU------------------------------ ---------------AG----A---------G-AU-C-C-U-CU-GG--UAGGG----GG ---G-CGCU-GUGA-UG-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGGUG-G--G-UCGU-GA-GAU--CCAC-U-GGA-CCCGUC-A--CAGGUGCAGAUCC-C GGCGG-UAGUA-ACAGC-G-AA-GGGGG-G------------------UGAGAAU----- ----------CCCCCU-CGCC-GGA-AGGGC-AAGGGUUUCC-CGGCAACGUUCGUCAGC CGGGAG------------UUAGCCGG-UC-C-UAA----GGUA-G-GGCCUAA-UAGGUA C--------------------------C-U-A---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAG-GGG--U UAA----CAUU-CCC----CUGCC-U-CC-C--GGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G UAA--------------------------------------------------------- ------CGC-A----------------------AG-CCAGAC-UCC-UG-AC--GGAU-U GGGGUA--GG--G-AGAGU-A-GGA--C-----CACC------G---UC-CUAC--CC-- -A------AGC------AC-U------C------A--------A---G-----C--CCUU G-G------A---GA-G--C--C-----G--UAA-C-GGU-GAGAA-GA--GG----G-C -G--A--AGGU-G--U--G-A--U-GG-G-CCU-UCC----------------------- ---------GU-UA--------------------------------GG-AGG--GUU--- CU-C----CU-GAUCC-C-UA-G-UCCC-CAUGAAA-A-G-GGAG---U--C-UGG-AA- ------------------------------------------------------------ -C--GAUC-CCG--GG-A-GACCGUACCUAGAACCGACACUGGUGCCCCUGGG-UGAGAA -G-CCCAAGG-CGUCU-GAGGGGUAACCCA-GGCUAGGGAACUCGGCAAAU-UAGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-AU--C-GU-GGUUU-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AC-A-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ A-----AGC-C-A--C-GAUAG-GUCGCAGUGACCAGAGGGACCUGA-----CUGUUUAA UAAAAACAUAGGUCCCCGC-UAGCCC--GA---A-A------------GGGUGU-GU-AC GGGGGCUA-AAUCCUGGCCACUGG-U-GGUUGGUUAAA-UCCGGG------------UUC A--------------ACCGGG-CGAAGCCCCA-C-CGAAGGC-CGGGGGUAACUCUGACC CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGCGCAUGAAUGGAUCAACG CG-G--UCCCU--ACUGUCCCAG-CC-UGG-GGCCUCGUGAACGCCCUGA-GCCGGUGCA CAGUCCGGCAUCUCCCUACACCGAGAGAAGA-CCCCGUGGAGC-UUCACCGCAGCCUGGC GUUGUCCCUCGGGCGUUUAUGCGUAGAGU-AGGUGGGAG-GGGU--C-GAA--CCU--GU CCU--------------------------------------------------------- ----------------------------------UUCG--GGGGC--AGGGGACC--CG- AAAG-UGAAACA-CCACCCAUGGACG-CUCGAGGGACUAA-CCU-C--UC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-AAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GAG-AGGAA -CAA-CGUCAGGUGGGCGGUUCGGCUGGGGCGGCACUCCCGCGA-AAAGAUAAC-ACGGG AGCCCAAAGGUCGGCUCAGGCGGUACAGAACGCCGCCGUA-GAGCGC-AAGGGCAAAA-G CCGGCCUGACGU-GACCCUUCCAA--GUACGGGGUCACGACGCGAAAGCGGGGCCU-AGC G-AACGCUCG------------------------UG---------C-CCCC-ACA-CGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC CGGGGA-UAACAGGGUCGUCGCGGGCGAGAGCUCACAUCGACCCCGCGGUUUGCUACAUC GAUGUCGGCUCUUCCCACCCUGGAGGUGCAGCUGCCUCCAAGGGUAGGGCUGCCCGCCCG UUAAAGGGGAGCGUGAGCUGGGUUUAGACCGUCGCGAGACAGGUCGGACUCUAAGGGUAG --GGA--G-UGC------------------------------------------------ -----GGACCGC-UUGAGGGGAAG-GAACCCCUAGUACGAGAGGAACAGGGUUCCGGGGC CUC-CAGUUUA-CCGGU-UGUCC-GGUA-GGGC-AA--UGCCGGGCAGCCG-C-GCCCUG -AG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CUC-CCCUAAA--- --AGAGGCG---------------------------GU--CA---------GG-C----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUUA----------------------------- -----------GCC--G-G---GGCCU---UCCC--C-UAGAAGAGGG-GG-UUGAUGGG GUGGG-GAUGUAAG-CUC-CAAGGU----U---------------GUAA--G--ACC--G -AGGAGU--U--UAGUC-----CGCC----A-CUCCCAA-UCAGGC-UC--C-CC-CC-- -------- >Sulfolobus_tokodaii --------CCAGGGG-CUGACGCCACCC-GGUGGAUG-GCU-CGGCU-UGG-G--CGC-C GAAGAAGGGCGCGGC-AAGCUGCGAAAUGCCCGGGUUAGGCGCAAG-CA-GCCGUU-GAC CCCGGGAUCCCCGAAUGGGAUA-UCCU--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------GG-------------UUA-C CGGCGCUCCC-----AGC-------------UCCUGC-A--------------------- ------------------UG-GGAGCGGGA-ACCCCCCGAACGGAAACAUCUUAGUAGGG --GGAGGAAAAGAAAUCAAAUCGAGAUCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAG AGCCCAAA-CCAAACCUGCCGGU--GAU---AAGCCGGUG--GGGAUGUGGUGUUA---- ----------------------------UUGGCCUCUGGCCUG--------GGGU----- ------UCGACCC-CAACCUCC--CUAG----CCCUCUGAG------CCG-AACUC-CCC UG-GA-------AUGGG------G-GGCC-AUAGAGGGUGAUAGCCCCGUAGGCGAAGGA ---GGG-UG---------GGA-----GGUGGCCA--GAGGCAGAGUACCAUCCCCU---G GUUUGGGGGUGGGAAGUUGGGGGACACG-UGCCUCCAAGGCUAAAUACGU--CC-CAAGA CCGAUAGC-GAACUUAGUACCGUGAGGGAAAGCUGAAA-AGAAC-CCCGGAAGGGGGAGU GAAA-AGAGCCUGAAACCGGGUGGUUA-CAG-AGGGC-AGGGCUCGAAAGGGGUGAGUCC ACCCGAA-----------------------------------GGAAAGGGC--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GUGAAGCCCGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGG----UGGAUGACCGGGGUCCUGCCUUUCGUCUUGAAACACGGGCCGG GGAGUUCA-C----GCCAGUGGCGA---GCUUAA-GGG--G----------GUUAA---- --------CCCC-G-A-A-AGCGUAGGGAAA-CCGAG---------CGCCCGC----AAC CCGG----GAAA---CCGGGU-G----AGGGG-CGA---------------------GGU CC----------------------------------------GUCA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------UG------------------ ------------------------GAGUCACUGGCGUGA-GGCUAGAAACCAG-GCGAUC UAGUCCGGGGCAGGCCGAAGUCGGG-GGAAACC-CCGAUGGAGGGCCGAAUAGGG-GUUC UGACGUGCAAUUCGUUCCCCUGACCCCGGACUAGGGGCAAAAGACCAAUCUAGCCUGG-U GAUAGCUAGUUCCUCCCGAAAUGCGUCUUAGCGCAGCCUCCCU-G--------------- ------------------------------------------------------------ -------------------GAGGU-CG-CCCGCGGGGUAGAGUGACAGAUCGGG--GG-U UC--C-AGA-C-GAAA--GUCUGG-GGCU-CCCGGUCUAACUCCGAACCCACG-GG--C- A-C--------------------------------------------------------- ------------------------------------------------------------ -----CGA-AG--AA--G-GGGGG-AGU-GGG-UCA--CC-CGGCG-UAAGGUUGGG-UG -GCAAAA-GGGGA----ACA--ACCCAGACUCG--GGUUAAG--GCCCC--UAAGUG--C C-G-GC-U-AAG--UGCCAA-UC----A--AAAGGCGUCCCCAGCCUUAGACAGCGGGAA GGUGGGCCCAG-CAGCAGCCAU-CCUCUAAGGAGUGCGUAACAGCUCACCCGCC-----G AGGCUGGGGGCCCUGAAGAUUGGUCGGGGCUC-A-AGCCG---GCC--------GCC--G AGA-CCCGAGG--GGU---A--G----GU-C---------------CC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ACU------------------------------ ----------------G----G---------GACC-U-A-C-UC-GG--UAGGG----AG ---G-CGCU-GCGG-UA-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CAGA AGGUG-G--G-CCGA-AA-GGU--CCAC-U-GGA-CCUACC-G--CAGGUGCAGAUCC-C GGCGG-CAGUA-GCAGC-G-AG-UAGGG-G------------------UGAGAAU----- ----------CCCCCA-CGCC-GGA-AGGGC-CAGGGUUUCC-CGGCAAUGGUCGUCAGC CGGGAG------------UUAGCCGG-UC-C-UAA----GGCG-G-GGCCUAA-CUGGUA C--------------------------C-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAG-GGG--U UAA----UAUU-CCC----CUGCC-U-CC-C--GGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AG-CCCGGC-UUC-UG-AC--GGAU-C GGGCUA--GG--G-GGAGC-G-GGG--C-----CACC------G---CC-CCGC--CC-- -A------AGC------GC-U------U------A--------A---G-----C--CCCU G-G------A---GA-A--C--C-----G--UAA-U-GGU-GAGAA-GG--GG----G-C -G--A--AGGC-G--U--G-A--U-GG-G-CCU-GCC----------------------- ---------GU-UA--------------------------------GG-CGG--GUU--- CC-C----CU-GAUGC-C-UG-G-UCCC-CAUGAAA-A-G-GAAG---C--C-GGG-AA- ------------------------------------------------------------ -C--GAUC-CCG--GG-A-GACCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAGAA -G-CCCAAGG-CGUCU-GGGGGGUAACCCA-GGCUAGGGAACUCGGCAAAU-UAGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-AU--C-AU-GGUCG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UA-AA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ C-----GGC-C-A--U-GAUAG-GUCGCAGUGACAAGGGGGACCUGA-----CUGUUUAA UAAAAACAUAGGUCCCCGC-UAGCCC--GU---A-A------------GGGUGA-GU-AC GGGGGCUA-AAUCCUGGCCACUGG-C-GGUUGGUGAAA-CCCGGG------------UAC A--------------ACCGGG-CGAAGCCCCG-C-UGAAGGC-CGGGGGUAACUCUGACC CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGCGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCCAG-CC-UGG-GGCCCCGCGAACGCCCUGA-GCCGGUGCA CAGUCCGGCACCCCCCUACACCGAGAGAAGA-CCCCGUGGAGC-UUCACCGCAGCCUGGC GUUGUCCUCCGGGCGCUCAUGCGUAGAGU-AGGUGGGAG-GGGU--C-GAA--GCC--GC UCC--------------------------------------------------------- ----------------------------------UUCG--GGGGC--GGUGGACC--CG- AAAG-UGAAACA-CCACCCAUGAGUG-CUCGGAGGACUAA-CCU-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-AAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GGGGA -CAU-CGUCAGGUGGGCGGUUCGGCUGGGGCGGCACUCCCGCGA-AAAGAUAAC-ACGGG AGCCCAAAGGUCGGCUCAGGCGGUACAGAACGCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACGG-GACCCUCCAAA--GUACGGGGUCCCGACGCGAAAGCGGGGCCU-AGC G-AACGCUCG------------------------UG---------C-CCCC-ACA-CGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC CGGGGA-UAACAGGGUCGUCGCGGGCGAGAGCUCACAUCGACCCCGCGGUUUGCUACAUC GAUGUCGGCUCUUCCCACCCUGGGGGUGCAGCUGCCCCCAAGGGUAGGGCUGCCCGCCCG UUAAUGGGGAGCGUGAGCUGGGUUUAGACCGUCGCGAGACAGGUCGGACUCUAAGGGUAG --GGG--G-UGC------------------------------------------------ -----UGGCCGC-CUGCGGGGAAG-GUACCCCUAGUACGAGAGGAACAGGGUGCCGGGGC CUC-CAGUUUA-CCGGU-UGUCC-GGUA-GGGC-AG--CGCCGGGCAGCCG-C-GCCCUG -AG-GGGUAACCGCUGAAAGCAUC--U-AAGCGGGAACCC------CUC-CCCUAAA--- --AGAGGCG---------------------------GC--CA---------GG-C--C-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCAA----------------------------- ----------GGCC--G-G---GGGCC---UCCC--C-CAGAAGAGGG-GU-UUGAUGGG GUGGG-GGUGUAAG-CCC-CAAGGG--------------------UUUU-----CCC--G -AGGGGU--U--UAGCC-----CGCC----A-CUCCCAA-UAG-GC-CC--C-UC-CCUU -GG----- >Thermococcus_kodakarensis ------CCGG-UGGCAACUAAGCCGCCU-GGUGGAUG-GCU-CGGCU-CGGGG--CGC-C GACGAAGGGCGUGGC-AAGCUGCGAUAAGCCCCGGCGAGGCGCAGG-CA-GCCGUC-GAA CCGGGGAUGCCCGAAUGGGACC-UCCC--------------------------------- -------------GCGG------------------------------------------- ----------------------------------------CU-------------UUU-G CCGCACUCCC-------------------------------AG----------------- -----------------UCG-GGAGGGGGA-ACGCGGGGAAUUGAAACAUCUUAGUACCC --GCAGGAAAAGAAAGCAAAA-GCGAUGCCGUUAGU-AGG-GGCGACCGAAAGCGG-CAC AGGGCAAA-CUGAACCCCGGGCC--GA----AAGGUUCGG--GGGAUGUGGUGUUG---- ----------------------------UAGGGCC----CGC-----------GG----- ------AGGAGCC-------CU-----G----GGGGCGAAG------CCG-AAGUC-CGC UG-GA-------ACGCG------G-CGCC-GGAGAGGGUGAAAGCCCCGUAGGCGUAAGC -C-CCC-GA---------GCU----CCUGC---GGUGUCCCUGAGUACCGUCGGUC---G GAUAUCCGGCGGGAAGCUGGGAGGCAUC-GGCUCCCAACCCUAAAUACGU--CC-CGAGA CCGAUAGC-GAACUA-GUACCGUGAGGGAAAGCUGAAA-AGCAC-CCCGG-GAGGGGGGU GAAA-AGAGCCUGAAACCAGGCGGCGA-UAG-GAGGG-UGCGGCCCGAAAGGGUUGACCC UCCCCGAA----------------------------------GGAAACACG--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACCGUGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG---AGGU-GACCGGGGUUGCACCGUCCGUCUUGGAUCACGGGGCAG GGAGUUCA-C----CCGAGCGGCGA---GGUUAA-GGG--G----------GUCAA---- --------CCCC-G-A-A-GCCGCAGGGAAA-CCGAC--------AGGUCCGC----AGC CC------GUAA-----GGGC-G----AGGGA-CGG---------------------GGU GU----------------------------------------GAAA-------------- ---------------------------------------------GCGCC---------- ----------------------------------------CG------------------ ------------------------GAGUCGCUCGGGUGA-GACCCGAAGCCGG-UCGAUC UAGCCCGGGGCAGGGUGAAGUCCCU-CAACAGA-GGGAUGGAGGCCCGCU-AGGG-GUGC UGACGUGCAAUUCGCUCCCGUGACCCCGGGCUAGGGGUGAAAGGCCAAUCGAGGCCGG-C GAUAGCUGGUUCCCGCCGAAUUAUCCCCCAGGAUAGCCCGGCC-G--------------- ------------------------------------------------------------ -------------------GAGGU-AG-GCAGUGGGGUAGAGC-ACUGAUUGGG--GG-U UUAGG-GGG-C-GAAA--GCCUCC-GGCU-CCCUGUCAAACUCCGAACCCACU-GC--C- G-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-GCCGG-AGU-AGG-GGG--G--CGGUG-UAA-GCCGUC-AC -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--AAAGUG--C C-G-GC-U-AAG--UGUUA--CUCC--A--AAGGGUGUCCCUGGCCUUAGACAGCGGGGA GGUAGGCUUAG-AAGCAGCCAU-CCUUUAAAGAGUGCGUAACAGCUCACCCGUC-----G AGGUCAGGGGCCCCGAAAAU-GGACGGGGCUU-A-AGCCG---GCC--------GCC--G AGA-CCCCGGC--G-C---A--C----GG-A---------------CC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAUU----------------------------- ----------------G----G---------UCCG-U-GAU-CG-GG--UAGGC----GG ---G-CGUG-CCGA-UG-------------------GG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CGGA AGCCG-G--G-CCGU-GA-GGU--CCGG-U-GGA-CCCGUC-G--GUAUUGCGGAUCC-U GCCGG-GAGUA-GCAGC-A-UA-GCCGG-G------------------UGAGAAU----- ----------CCCGGC-CGCC-GUA-GGGGC-CAGGGUUCCA-CGGCAAUGUUCGUCAGC CGUGGG------------UUAGUCGG-UC-C-UAA----CCCG-A-CCCGUAA-CUCGGC G--------------------------U-C-G---------------------------- ------------------------------------------------------------ ----------------------------------GG---GA-AA-GGGA-AAC-GGG--U UUA----UAUU-CCC----GUACC-G-CG-G--UGGU-A-G--G-U----G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-A----------------------AG-CCCGAG-GGG-UG-AC--GCCU-C GGGGUA--GG--C-GGACC-G-GUC--C-----ACA-------A---GG-CCGG--CU-- -A------AGC------GU-A------U------A--------A---G-----C--CCGG G-G------A---GU-G--C--C-----G--UAA-U-GGC-GAGAA-CC--GG----G-U -G--A--AAGC-G--C--G-A--A-UG-G-CCU-CCC----------------------- ---------GU-AA--------------------------------GG-GGG--GUU--- CC-G----CC-GAUCC-C-UG-G-GGCC-CGUGAAA-A-G-CCCC---U--C-GGG-AA- ------------------------------------------------------------ -C--GAUC-CAC--CG-C-GACCGUACCGAGAACCGACACUGGUGCCCCUGGG-UGAGAA -G-CCUAAGG-CGUGU-CGGGGGAAACCCA-GCCGAGGGAACUCGGCAAAU-UGGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-GC--G-GG-U------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G UG-UA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------A-C--C-CGCAG-GUCGCAGUGACUAGGGGGGCCCGA-----CUGUUUAG UAAAAACACAGGUCCCAGC-UAGCCC--GA---A-A------------GGGUUU-GU-AC UGGGGCCG-ACGCCUGCCCAGUGC-C-GGUAUGUGAAG-CCCGGG------------UAC A--------------ACCGGG-UGAAGCACCG-G-UAAACGG-CGGGGGUAACUAUAACC CUCUUAAGGUAGCGAAAUUCCUUGUCGGU-UAAAUGCCGACCUGCAUGAAUGGCGUAACG AG-G--UCCCC--ACUGUCCCCG-GC-UGG-GGCCCGGCGAAACCUCUG--CCAGGCGCA UAUGCCUGGGACCUCCGGUGGGAAGCGAAGA-CCCCAUGGAGC-UUUACUGCAGCCUGCC GUUGCCGUACGGCGGGGGGUGCGCAGCGU-AGGCGGGAG-GCGU--C-GAA--GCC--CG CCC--------------------------------------------------------- ----------------------------------UCCG--GGGCG--GGUGGAGC--CG- CCCA-UGAGACA-CCGCCCACCCUCU-GCCGUACGGCUAA-CCC-G--C----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-GAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GC-GGGGA -CAG-CGGUAGGUGGGCAGUUUGGCUGGGGCGGCACACCCUCGA-AAAGGUAUC-GAGGG UGCCCUAAGGUCGGCUCAGGCGGGUCAGGAAUCCGCCGUA-GAGUGC-AAGGGCAAAA-G CCGGCCUGACUG-GACCCGUAACAGA-GG-CGGGUCCAGCCGCGAAAGCGUGGCCU-AGC G-AACCCCUG------------------------UG---------C-CUCC--CC-GGU- ----------------------------GGGGGCCAGGGAUGA-CAG--AAAAGCUACCC UGGGGA-UAACAGAGUCGUCUCGGGCGAGAGCCCAUAUCGACCCCGAGGCUUGCUACCUC GCUGUCGGCUCUUCCCAUCCUGGCCCUGCAGCAGGGGCCAAGGGUGGGGGUGUUCACCCA UUAAAGGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUCGGAUGCUAUCUACCG --GAG--G-UGU------------------------------------------------ -----UGGCCGC-CUGAGGGGAAG-GCUCCCCCAGUACGAGAGGAACAGGGAGCCGCGGC CUC-UGGUCUA-CCGGU-UGUCC-UACA-GGGC-AU-A-GCCGGGCAGCUA-C-GCCGCA -GC-CGAUAAGGCCUGAAAGCAUC--U-AAGGCCGAAGCG------GCC-CCCGAAA--- --ACAGGCG---------------------------GC--CAC--------UC-C--U-- G-GGCG-U-U-GGGCCU-GG---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCGA-----------------------CCGGUC CGUUGC-CC-AGGA--C-G---AGGGC---CCGG--G-AAGAAGACCC-GG-UUGAUGGG GCGGG-GAUGUAAG-CGG-GAAGG---------------------GAAA------CC--G -ACCCGU--U--CAGUC-----UGCC----G-CUCCCAA-CAGCCC-GA--G-UG-CUAC -CGGGC-- >Thermofilum_pendens ---------------CGCUAAGCCACCC-GGUGGAUG-GCU-CGGCU-CGG-G--CGC-C GAGGAAGGCCGUGGC-AAGCGGCGAUACGCCCCGGGGAGCCGCAUG-CA-GGCUUC-GAU CCGGGGAUCGCCGAAUGGGACC-UCCU--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------UG-------------GGU-C AACCCAC--------GGC-------------GCUCGG-G-AAACCCGCAAGGG------- --------------GAGUAC-CGAGCGGGA-ACCCCCCCAACGGAAACAUCUUAGUAGGG --GGAGGAGAAGAAACCAAUU-GGGAUCCCCUGAGU-AGG-GGCGACCGAAAGGGG-GAG AGCCCAAA-CCGAACGUCCAUGC--GAA---GAGCAUGGA--CGGAUGUGGGGUUG---- ----------------------------CAGGGCCCCGCGUCC----------------- -------------------CCC--CUAG----CCCGGAUAG------CCG-AAGUC-GGC UG-GA-------AAGCC------G-CGCC-GUAGAGGGUGACAGCCCCGUAGGCUAAAUC --CGGG-UG---------GGG-----GAUGGCGGGUGUCCCUGAGUACCACGGCUU---G GUUUUGCCGUGGGAAGCUGGGGGGCACC-GACCUCCAAGGCUAAAUACGU--CC-CGAGA CCGAUAGC-GAACUAAGUACCGUGAGGGAAAGCUGAAA-AGCAC-CCCGGAAGG-GGGGU GAAA-AGAGCCUGAAACCGGGUGGCGA-CAG-GUGGC-GCGGCCCGAAAGGGUAGAUCCU CCCCGAA-----------------------------------GGAAACCCG--G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCGACCGGGGAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----UACGAGGGG-AGGGG---ACCGGGGUCGCGCCUUACGUCUAGAAACACGGGCCGG GGAGUUCA-C----GGCUGUGGCGA---GCCUAA-GGG--G-U---------UCAAG--- --------CCCC-G-A-A-GGCGUAGGGAAA-CCGACA--------AGCCCGU----AGC CAGCC---GCAU--GGCUGGU-G----UGGGG-CGG---------------------GGU CU----------------------------------------GAAA-------------- ---------------------------------------------GGGCC---------- ----------------------------------------CG------------------ ------------------------UAGUCACAGCCGUGA-GACCAGAAACCGA-GCGAUC UAGGCCGGGGCAGGGUGAAGCCCGG-CGAAAGC-CGGGUGGAGGCCCGA--AGGG-GUUC UGACGUGCAAUUCGUUCCCAUGACCUCGGCCUAGGGGCAAAAGACCAAUCAAGCUCGG-U GAUAGCUGGUUCCCCCCGAAGCGGAUCCCAGUCCGGCCCGCCC-U--------------- ------------------------------------------------------------ -------------------GAGGU-UG-CCGGUUGGGUAGGGC-ACUGAUUGGG--AG-U CCGGG-GAC-C-GAAA--GGUCCC-AGCU-CCCUUUCAAACCCCGAACCGACC-GG--C- A-C--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-GGCGG-AGA-CGG-GUU-CUG-GCGGA-UAAGCCGCCA-GG -CCGAGA-GGGGA----ACA--ACCCAGACCGG--GGUUAAG--GCCCC--CAAGUG--C C-G-GC-UAAAG--UGUCAAGCCA---G--AAGGGUGUCCCCCGCCUUAGACAGCGGGGC CGUAGGCUUAG-AAGCAGCCAU-CGGCUAAGAAGUGCGUAACAGCUUACCCGCC-----G AGGCGGGGGGCCCCGAAGAUU-ACCGGGACU--A-AGCCG---GCC--------GCC--G AGA-CCCCGGG--G-C---A--C----CC-C---------------GC------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUU------------------------------ ----------------G----C---------GGGG-U-GAU-CC-GG--UAGGG----GG ---G-CGUC-CAGG-UG-------------------GA-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UGGA AGCCG-G--G-CCGU-GA-GGU--CCGG-U-GGA-UCCGCC-U--GGAAUGAAAAUCC-C GGCGG-UAGUA-AGAGC-GCAA-GAGGG-G------------------UGAGAAU----- ----------CCCCUC-CGCC-GAA-AGGGC-AAGGGUUCCU-CAGCAACGGUCGUCGGC UGAGGG------------UUAGCCGG-UC-C-UAA----GGCG-G-CCCUUAA-CCGGUG ---------------------------C-C-G---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AAG-GGG--U UAA----UAUU-CCC----CUGCC-G-U--G--GGGU-A-C--G-CUUU-G--C----G- -----------------------------------------------------------G CAA--------------------------------------------------------- ------CGC-G----------------------AG-CCCCGC-UCC-UG-AC--GCCU-C GGGAUA--GG--G-GGAGU-G-GGA--C-----UGCC------G---UC-CCAU--CC-- -A------AGC------GC-U------G------A--------A---G-----C--CCGC U-G------A---GU-G--C--C-----G--UCA-U-GGC-GAGAA-GC--GG----G-U -G--A--AGGC-G--C--G-A--U-GG-G-CCC-GCC----------------------- ---------GU-UA--------------------------------GG-CGG--GUU--- CC-C----CC-GACUC-C-UG-G-GGCC-CGUGAAA-A-G-GGAG---C--G-GGG-AA- ------------------------------------------------------------ -G--GAGC-CCC---A-C-GCCCGUACCGAGAACCGACACAGGUGCCCCUGGG-UGAAAA -G-CCCAAGG-CGUGG-CGGGGU-AACCCA-GGCUAGGGAACUCGGCAAAU-UAGCCCCG UAACUUCGGG-AGAAGGGGUGC-CU-GC--G-GU-CUUGGGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C AU-AC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------C-C----- C-----UGG-G-A--C-CGCAG-GUCGCAGUGACAAGGGGGACCCGA-----CUGUUUAA UAAAAACAUAGGUCCCCGC-GAGCCC--GA---A-A------------GGGUGA-GU-AC GGGGGCUG-AAUCCUGGCCACUGG-C-GGUACGUGAAA-CCCGGG------------UAC A--------------ACCGGG-CGAAGCGCCG-C-CGAAGGC-CGGGAGUAACUCUGACU CUCUUAAGGUAGCCAAAUGCCUUGCCGGG-UAAGUUCCGGCGCGCAUGAAUGGAUCAACG AG-G--UCCCC--ACUGUCCCAG-CC-UGG-GACCCGCUGAACCCGC-AA-CCAGGUGCA GAGUCCUGGGAGUCCCGGUGGGGCGAGAAGA-CCCCGUGGAGC-UUCACAGCAGCCUGGC GUUGAGACACGGCUGCGGGUGCGUAGCGU-AGGCGGGAG-CGAU----GAA--CCU--GG CCC--------------------------------------------------------- ----------------------------------UCCG--GGGUC--AGGGGAUG--CG- GCCA-UGAAACA-CCGCUCACCUGCG-GCUGUGUCCCUAA-CCC-C--GG--------G- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-UUU-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------C-CCG-GGGGA -CAG-CGCCAGGUGGGCUGUUCGGCUGGGGCGGCACACCCCUGA-GAAGGUAUC-AGGGG UGCCCAAAGCUCGGCUCAGGCGGGUCAGAACUCCGCCGUA-GAGGGC-AAGGCCAAAA-G CCGGGCUGACUG-CGCCCUUAAAC--GCGUGGGGCGCAGGCGGGAAACCGGGGCCU-AGC G-AACGCUCG------------------------UG---------C-CCCC-UUC-GGU- ----------------------------GGGGGCCGGGCAUGA-CAG--AAAAGUUACCC CGGGAG-UAACCGGCUCGUCGCGGGCGAGAGUUCACAUCGACCCCGCGGUUUGGUACCCA GACGUCGUCUCUUCCUAGCUUGGCCCUGCAGCAGGGGCCAAGAGUGGGGCUGCUCGCCCA UUAAAAGGGAACGUGAGAUGGGUUUAGACCGUCGCGAGACAGGUCGGACUCUACCUGCCG --GGA--C-CGU------------------------------------------------ -----UGGCCGC-CUGAGGGGAUG-GUCCGCACAGUACGAGAGGAACUGCGGGCCGUGGC CUC-UAGUGUA-CCGGU-UGUCC-GGCA-GGGC-AC--UGCCGGGCAGCCA-C-GCCGCA -AG-GGGUAACCGCUGAAGGCAUC--U-AAGCGGGAAACC------CAC-CCCGAGA--- --CGAGGCG---------------------------GC--CGCU-------CC-C--G-- A--UCC-G-UUGCUCCC-G----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCGA------------------------CGGGG GCUUUGGGU-CGGGA-C-G---AGGGC---ACCC--G-UAGAAGACGG-GG-UUGAUGGG GUGGC-GGUGUAUG-CGC-CGAGGG---------------------UU------UCC--G -AGGCGC-----GAGCC-----GGCC----A-CUCCCAA-UAGCCC-GA--G--G-C--- -------- >Thermoplasma_volcanium -----------GCUCUGCUAAUCUGCCU-AGAGGAUG-GCU-UGGUU-CGG-G--CGC-C GAAGAAGGACGUGCC-AAGCUGCGAUAUGCCUUGGGGAGGCGCAUG-GA-GCCAUA-GAU CCAAGGAUUUCCGAAUGGGACU-UCCU--------------------------------- -------------GCCG------------------------------------------- ----------------------------------------UA-------------AGG-C ACUCCG------------------------------------------------------ -----------------AAA-GGAGAGGGA-ACCCGGGGAAUUGAAACAUCUUAGUACCC --GGAGGAAAAGAAAUCAAUC-GAGAUACCGUUAGU-AAA-GGCGAUCGAAAGCGG-UAA AAGGCAAA-CCGAAUAGCCCUUC--GA----AAGAAGGGA--AAGAUGUGGAGUUU---- ----------------------------GGUCUUU----CUC------------U----- ------AA-----------UGC--CUCC----UGAAGCGAG------AUG-A-AUC-UUC UG-GA-------AAGAA------G-AGCC-AAAGAAGGUGAUAGCCCUGUAAUCGAAGCU -U-CAG-AA---------GCU----AUAAGGGGAAGUAACCAGAGUACCAUGCGUC---G UUUUUCGCGUGGGAAUGUGGGUGGCACU-AACAUCCAACCUUAAAUACGU--CC-CGAAU CCGAUAGC-GAACUAAGUACCGUGAGGGAAAGCUGAAA-AGUAA-CCCGA-AAGGGUGGU GAAA-AGAGCCUGAAACUAGGCAGAGA-UAA-CCUUG-UAGGGCAGUAAAGAG-GU---- -------------------------------------------GAUACCGU--U------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------A--A-------C------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AACG----G---UGGAUCGC---UGUCCUAUUGUCCGUGUUGAAGAACGGGCCAG GGAGUUCU-G----ACGGGUGGCAA---GGUUAA-UCC--U-----------UAA----- --------AGGA-G-A-A-GCCGUAGCGAAA-GCGAU---------UACCCGC---ACA- --------GCAA--------U-G--G-AGGGG-UAG---------------------CGU GG----------------------------------------UAA--------------- ---------------------------------------------ACGCG---------- ----------------------------------------UU------------------ ------------------------UAGUCACUCGUGAGA-GACCCGAAGCCGG-UCGAUC UACACCUGAGUAGGUUGAAGCUCAG-UGAAAGC-UGGGUGGAGGACCGA--ACCU-AUUC UGAUGUGCAAAUCGUUUGGAUGACUUGGGUGUAGGGGUUAAAGGCCAAUCUAGGCCGG-C AAUAGCGGGUUCCCCCCGAUACUACCCGCAGGUAGACCUCGAC-G--------------- ------------------------------------------------------------ -------------------GAGAU-UC-UCGACGAGGUAGAGCGACCGAUUGGU-UGG-U UA-GC-AGU-C-GAAA--GGCUGC-GCCG-ACUUGUCAAACUCCGAACUUGCC-GA--G- A-U--------------------------------------------------------- ------------------------------------------------------------ -----CGU-AG--AU--G-UCGGG-UGC-UAG-GGG--GC-AGGGA-UAAGCUUUGC-UU -CCGUGA-UGGAA----ACA--ACCAAGACGAG--GGUUAAG--GUCCC--UAAAUU--C U-G-GU-U-AAG--UGCA---C--U--A--AAUAG-GUUUGUGGCCAAAGACAGCGGGGA GGUAGGCUUAG-AAGCAGCCAC-CCUUUAAAGAGUGCGUAACAGCUCACUCGCC-----G AGGUCACAUGCCUAGAAGAUG-GAAGGGGCUA-A-AACCA---GAU--------ACC--G AGA-CCUUCGA--G-C---A--C----C-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GAAA----------------------------- ---------------------------------GG-U-GAU-CU-GG--UAGGG----GG ---G-CGUG-CCAU-GUG------------------GG-C-------------------- ------------------------------------------------------------ ---------------------------------------------------------AGA AGUUU-C--U-UCGA-GA-GGA--GGAA-U-GGA-CCGCAU-G--GUAUCGCGGAUCC-U GGUAA-AAGUA-GCAGA-GA-A-GAACC-G------------------UGAGAAU----- ----------CGGUUC-CGCC-GAA-AGGGCUAAGGGUUCCU-UGGCAAUGUUCGUCAGC CGAGGG------------UUAGUCGA-UC-C-UAA----GGUC-A-UACCUAA-CAGGAU A--------------------------U-G-A---------------------------- ------------------------------------------------------------ ----------------------------------CC---GA-AA-GGGA-AGC-CGG--U UAA----UAUU-CCG----GCACA-C-UG-A--GCGU----------------------- -----------------------------------------------------------U UU---------------------------------------------------------- -----------------------------------GCCAUGU-GUG-AG-AA--GGUU-C GAGGUA--GG--A-GCGGU-A-CGG--G------UGCC-----A---AC-GUAU--UU-- -C------UGC------CU-A------U------A--------A---G-----C--GGAU G-G------A---GA-G--U--C-----G--UAA-U-GAC-GAGAA-GU--UC----G-U -G--A--AAGG-G--U--G-G--A-AG-C-UCC-C------------------------- ---------GU-UU-----------------------------------GGG--AGUC-- GC-U----UC-GAUCC-U-UG-G-AUCC-CAUGAAA-A-U-CAUA---C--A-UGG-GUC ------------------------------------------------------------ -----A-A-ACU--CA-G-UAUCGUACCAAGAACCGACACAGGUGCCCCUAGG-UGAGAA -G-CCUAAGG-CGUUU-UGGGA-UAAUGGA-CGCGAGGGAAAUCGGCAAAA-UAGCUCCG UAUCUUCGGU-AUAAGGAGUGC-CU-AU--U-CC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G CG-AU------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------G--G-AAUAG-GUCGCAGUGGCGAAGGGACUCCGA-----CUGUUUAC CACAAACACAGAUCGCUGC-UAGUCC--GU---A-A------------GGAUGU-GU-AU AGCGGUUG-AAACCUGCCCAGUGC-U-GGUACCUGAAA-GCCCCG------------CAC A--------------AGGGGA-AGAAGGGCCA-G-UAAACGG-CGGGGGUAACUAUGACC CUCUUAAGGUAGCGUAAUACCUAGCCGCU-UAAUUGGCGGCUUGCAUGAA-GGUUCAACG UG-G--GUCCC--ACUGUCCCCG-CG-UUC-AGCCCAGUGAAAUUGA-UGUACUGGUGCA CAAUCCAGUCUCUCCCACGUGAAAGCGAAGU-CCCCGUGGAGC-UUUACUGCAGCCUGUA GCUGUGAUGCGAUCCUGAAUGCGUAGCGU-AGGAAGGAG-CCGU--C-GAA--GCU--UC GGU--------------------------------------------------------- ----------------------------------UUUG--GCCGA--AGUGGAGG--CG- CCAA-UGAAACA-CUUCCCUUUCGGG-AUUGCGUCACUAA-CCU-C-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GUUA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G-AGGGA -CAA-CUAUUGGUGGGCAGUUUGGGUGGGGCGCCACGCCCCUAA-CAAUGUAAC-AGGGG CCCCCAAAGGUCAGCUCAGGAGGGUCAGAAAUCCUCCGUA-GAGUGU-AAAAGCAAAA-G CUGGCUUGACUG-UGUUGCAGACAAC-U-AGCAACGCAGAUGCGAAAGCAGGGUUU-AGC G-AACCACCC------------------------AG---------UUCCUC-CUU-AGU- ----------------------------GGGGGCGGGUGAUAA-GAG--AGAAGUUACCC CAGGGA-UAACUGAGUCGUCCUCGGCAAGAGUACACAUCGACCCGAGGGUUUGCUACUUC GAUGUCGUCUGUUCCUAUCCUGGUGCUGCAUAAGGUGCCAAGGGUGGGGCUGUUCGCCCA UUAAAAGGGAUCCUGAGAUGGGUUCACUACGUCGCGAGACAGUAGGGUUGCUUCUCCGUG --GGA--G-UGC------------------------------------------------ -----UCGAUGU-CUGAGGGGAAG-GGGCCUUUAGUACGAGAGGAACAAGGGCUCGUGAC CUC-UAGUUUA-CCGGU-UGUCC-GGCA-GGGC-AU--CGCCGGGUAGCCA-C-GUCAUA CGC-GGAUAAGAGCUGAAGGCAUC--U-AAGCUCGAAGCC------GCC-CCCGAAA--- --AUAGACA---------------------------UC--GU------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CAU----------------------------- ------------------U---AGGCC---GCCU--C-UAAAAGAGAG-GU-UUGAUAGG GCCGG-GAUGUAAG-GAU-CGAGC---------------------UUUU------GC--G -AGAUUU--U--AAGUC-----CACG----G-CUACUAA-A-GGCC-GA-----A-AGCA -CAAUC-- >Adineta_vaga -----------------UAAUUCUGUAC-GGUGGAUC-ACU-CGGCU-CGU-U--AUU-C GAUGAAGAGCGCAGC-AAAGUGCGAGAAAGCAAUGCGAAUUGCAGG-AC-ACA-U-UGAG CAUGAAUAACUCGAACGCAUCU-AGC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AGCCGCUGAACUUAAGCAUAUUAAUAAGC --AAAGGAAAAGAAAUCAACUGAGAUUGCCUUA-GU-AAU-GGCGAAUGAACCGGCAAA- AGCUCAUUGCUGAAGCGUGUU-A--------GAUUUACUUCUGACAUGCAUUGUAG---- ----------------------------CAUUUGGGG--------UAACUACUGUAUGGU GCCUGUUCGUGUGAGUUCCUUU--GAUCAG--GGCUUUAAC-CA---UAG-AAGGU-GCU AG-U--------CCUA-------U-AAUC-ACGAAUAGUUCUGUGCC-GUA--------- -----------------------C-AUUGUCUACCUUUC---GAGUAGCGUAGUUU---G AGAUUGCUACGCCAACGUGGGACGUAAACUUGUUCCAAAGCUAAAUAUUAU-AA-CGAGA CCGAUAGC-GAA-CAAGUACCGUGAGGGAAAGUUGAAA-AGCAC-UCUGAAGAGAG-AGU UAAAUAGUACGUAAAACCGUACAGAAG---A-AAACG-AAUGGCCGCAUUCAU------- -------CAGAUUACU--UUGGAUUCAAUUCGAU--UUCUAUAUGAUGGUA--AUACAUG UUGAUUUGGAACUUCAACAGUCCAUUGAUAUGUUCUUGCCUAGAAUCGGAUGCAUUUUCA AAGUAUUAACUGAACCUGGAUCUAUAACAUUACAGCUAGUCGAAUCAGUCUAUUUUGGUA GCGACUUUUAGUCGUGUUAAAAAUAUGACUUGCAUAAAUAACAAAUUCGACUUG---GCG UUAUAGGUAAAC-UGACGUGUUCUUUGAUUUCAGUACUUUCGAGUACGGCACGCCAUGAG CAUUGUUUGUGU-UACAUGAGUAACUAAUAUCUAAACAA-------UAUUAG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -UUUUAUUCAUUGUCAAUGCC--------------------------------------- ---------------------------------UAAUGUUUUGUGGCUGUCAAUGAAAUC GGCAAGUCAACAGGAGUUUUGAAUGCCGAGUUAUUCGACCCGUCUUGAAACACGGUCUAA GGAGUUCACUG---CAUGUGCAAGA---GUUCGG-CUG--U-----------AUGAAA-- --------AGCC-U-U-G-CUCGUAAUGAAA-GUAAAG-------AACA----------- ------UUCUUG------------------------CAA------------------UGU UUGA-AGU--GUGAUUU---CU----------GUCAUCUGGUGCAA--------A--U-- C--A--U----GA----C--A----A--U--G--A--ACGCAACACUGACA---GGUUCU A--U-U----G----CC----------------------GCUGG---------------- ------CAAAG-AGCUUAGU-AA-GAGUAUAUGCAAUGA-GACCCGAAAGAUG-GUGAAC UUAACGUGUGUAGAAUGAAGCCAGG-GGAAACC-CUGGUGGAAGUUCGU--AGCGGUUCU -GACGUGCAAAUCGAUCGUCAAACAUGCGUUAAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCGUCCGAAGUUUCCCUCAGGAUAGCUGGCAU-U--------------- --------------------------------------------------CAAU--UUU- ---CAC-------------------AGUUAUAUCCGGUAAAGCGAAUGUUUAGAGGCA-U UG--G-GCG-U--AAA--AUACGCUCAACCUAUUGACAAACUUUAAAUGGGUA-UG--A- A---GUU-CAUUUU---UC-UACUUC-------------------AUUG-A-G--AAU-- -GAA-C--------------------------------------------------AGCG -AAU----G-U--GA--G-UGCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGCUG-UUGGA----UGC--ACAAAACGUCA--AGAUAAA--GAGCC--AGAUGG--U CUC-GC-U-CAU--C-AGA-UACC--AUA-AAAGGUGUUGGUCGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGUUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCGACUAGUCCUAAAAAUG-GAUGGCGCUC-G-AGCGA---GCC--------UCU--U AUA-CUUGACU--GUU---A--C----GA-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------ACAACAAGCCAUUAACGGACAUCAU---------------- -------------------------------GUCG-U-A-A-CA-A--GUAGGA---CGG ---U-UGAU-AUGG-UU-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UCGA AGGCUAA--C-ACGU-GA-GUG--UGGC-U-UGA-GCAGUC-A--UAUGUACAGAUCU-U AGUGG-UAGUA-GCA-A--CU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GACGUGGAG-AAAGGUUCCA-UGUGAACAGCUAUUGGA CAUGGG------------UCAGUCAG-UC-C-UAA----GAUGCG--CUCGAA--AGAGG ---------------------------G-U-U-CCGAAC---GAG-GAA----------- ----------------UAUCUAUAUUCAUAUCAUA------------------------- ---UUU-----A-UAU-U--CCAUC------AAAUC---GA-AA-GGGA-AAC-AAG--U UAA----UAUU-CUU----GUACU-A-AGUG--UCGG-A-GAU--U----G--U------ ---------------------------------------------------------UUG AUUU----------------------------------------------------CGUG ---UCAAAC-AUA-U-G--UGGUAACAC-A----A-ACAAGC-UCAA-A-UA-CAUCA-C AAGU----GGUCC-UG-GA-A-AGAG------UUUUCUC-------UUC-UUU---GU-- -U------ACU------UCAU-----CA------G--------AC--G-----A--CCCU G-G------A---AU-C--A--G-----U--UCAAC-UGG--AGAU-AG--GG----U-U -C-A---AAUG-A--A--G-G--U-AA-A-GAG-UAGCC--------------------- ---------GU-UC-----------------------------UU-GC-UAC--UU---C CU-CGGUGCA----UC-A--UUUGUGAUCCUUGAAA-A-UUUGAGCGAG--AUA------ -----------------------------UUCA--------------------------- -A--UUUC-GCA--CU-U-AUCUGUACUCUAAACCGCAUCAGGUCUCCA-AGG-UGAAAA -G-CCUCUAG-UCAAU-UAGA-ACAAGGUA-GCACAAGGGAAGUCGGCAAAAUCGAUCGG CAACUUCGGG-AUAACGAUUGGCUC-UA--A-GU-GCUAGGG-UG-UU-CGGG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CUUGA---U--GAU----AAAGCAGU---A--G--ACUUGCUAUUGGAG CUGAGCUUUC-------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------GG AUGCAGCAAUGUG----------------UCUGAUCGUUCGGACU-AG--UGGCUUGUCU U-GCUGUG-------------------GAA-----UCGU-----UUUGCU------ACGG -U-AUGC----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGUUCG--------------------------- ---------------CUUG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------CGG-G--UCGUAUUA--------------C-UUC---GGACAUCGU--- UUAA--UAG-C-AAAC-UUAGAACUCGCUGCGUCUAGGGGAAUCCGA-----CUGUCUAA UUAAAACAGAGCUUUGCGAUUGGCCG--GAAAAC-U------------UGGUGU-UG-AC GCAAAGUG-AUUUCUGCCCAGUGCUC-UGAAUGUUAAC-GUGAA-------------GAA A---------------UUCAA-AUAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUCUGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUG-UC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGACUUCAAUGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAAUCUGUC UUCGUAAAGAGACUUGAAAAGUGUAGCGU-AGAUGGGAG--------------------- ------------------------------------------------------------ ----------------------------------UGGC-------------AACA--CG- UCAA-UGAAACA-CCAUUAUUUUCAUUGUUUCUUUACUUA-CUU-G--GUUA--UA--CA GA---------------------GAU-U-GG-AUUUU--------------ACAU----- CC------AGU-G-U--U-U-GAG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------UGACAAACGUCGAUACUUG ------------------------------------------------------------ ---------------------------------------------UA------------- ----U--CAA----------------------------CGU------------------- ----------------GAU--CU-----------------------GC-UUCAA-GGAA- --AG-AGACAGGUGGGGAGUUUGGCUGGGGCGGUACAUCUAUCA-AAUGUUAAC-GUAGG UGUCCAAAAGUUGACUCAGUGCGGACAGAAACCACACAUU-GAGUAA-AAGGGCAUAA-G UCAGCUUGAUUU-AGAUUUUC-A---GUACGAAUACAGACGGAGAAAUCCGGGCCU-AUC G-AUCCUUUU-------------------------G--A------UUUAAC-GAG-UU-- ----------------------------UUUUGCAAGAGGUGA-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGCGAAGCAGACUUCGCAAAGUGUUGGAUUGUUCACCCA CCAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACA- --UUGGAUUUU------------------------------------------------- ------GUCAUU-GAUAUAGGAA--UCGUACUUAGUACGAGAGGAACCGUACGUUCGGAC AUU-UGGUUUACGUAUU-UGUUC-GAAA-GGAC-AA--UGAUGCGAAGCUA-CCAUCCGA --C-GGCUUACAACUGAACGCCUC--U-AAGUUGGAAUCC------GAU-CUA--GA--- ---CUCAAU---------------------------GA--UUUUUU-----GG-C--A-- C--AUU-G-GUUG----------------------------------------------- ---------------------------------------UC--GUCAGCAC--------- ------------AU---UUAUAUAUGUUCAAACUGUUGAUCAAGUGAACAUAUGAAUGAA GCUACCGUAUUGUUGCCUCGUCAUAAUCGAAAU--------------------------- -------GAGAUUGUGAUUGCAACGAUGCA------------------------------ -----------UUUUUAGUCGAAA------------------------------------ CAA--------------------------------------------------------- ------------------------------------------------------------ CACUAAUGG-CUAG--------AAUC----GAUU--G-UAAACGACUU-UC-UUCAGUAA CAGAGUAACGUACA-CGUGAGAGCAA--C-C--------------GCCAC--AUUGC--G -AUCCGC--U--GA---------------------------------------------- -------- >Aedes_albopictus -------------------ACCCUAGGC-AGGGGAUC-ACU-CGGCU-CGU-G--GAU-C GAUGAAGACCGCAGC-UAAAUGCGCGUCAGA-AUGUGAACUGCAGGACA-CA--U--GAA CACCGACACGUUGAACGCAUAU-UUAUC-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AGUAGGCCUCAAAUAA-UGUGUGACU-ACCCCCUAAAUUUAAGCAUAUUAAUAAGG --GGAGGAAAAGAAACUAACAAGGAUUCCCUGA-GU-AGC-UGCGAGCGAAACGGGAAG- AGCUCAGCACGCAGGGGCGAUG-CACUGGUGUAU--CUG--CCCGGUUCCGUGUAC---- ----------------------------UGGAGAGUU----------------------- ------------CGUUAUCUGCGUA--ACC--GGUCGCUGG------UUC-AAGUUCAAC UA-GA-------AUGUGGCUUUUA-CUCCCAGAGAGGGUGAUAGGCCCGUAGAGCGGCGC -AC-CGAUG---------G------UAGAAGAUCUUUCCAUGGAGUCGUGUUGCUU---G AUAGUGCAGCACAAAG-UGGGAGGUAAACUCCUUCUAAAGCUAAAUAUCAC-CA-CGAGA CCGAUAGC-GAA-CAAGUACCGUGAG-GAAAGUUGAAA-AGCAC-UCUGAAUAGAG-AGU CAAAAAGUACGUGAAACUGCCUAGGGCU--C-AAGCC-CGUUGAACUCGAUUAUCCGAGC GGAGACAUUCACC-----UG----CGGUUG-GCC--GGC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G ACG-GCA----C-GGCCGCAGGGCACUUGUCUCUCGCACUAGCCAAGAG-------GAC- ----ACUGCGAU-CCAUUACGAAAC--------AGCUUU-------CGCGCAAGCGCAAG GUCGCCCGACA--AC--------------------------------------------- --UG-C-------------------------CCCCUGGUGCUGGUUGC------UUGCC- -CCACAGUAGCGACGCUCAG--UUCU-----GA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AGGCCUG--- UGCC------------------------------------GCGAGGUG------GGGCUU A-CUGCACGU-GGUGUUCUAGCAGUCG-----------G---------------GCGCGU GAUGG-A--UUCCCCCGG---------ACACCGG--GUGGU----------------CUU -CCCGUAAG------G--------------G----G------------------------ --------------------------------------------------------CCAC C------GGACUGUCGAUCGGCAG------------------------------------ ------------------------------------------UGA--------AA-GAA- ----UCGAGGU-----------------ACCUUCGGGACCCGUCUUGAAACACGGACCAA GAAGUCUA-U----CUUGCGCGCGA---GCCAAU-GGUC-G-U--CC-----UCC----- ----GGAGCACC-A-A-A-GGCGCAGAAAAC-AUAACUUGA-------GU---------- -------UGU--------------------GC-------------------------GGG AUUACGGG--C-GCG---G--C----------U---------CUC--------------- -----------------U--G----C--U--C--G---UCCCUCCAUCCC-----CGGGU GU-U-G-UAAUC--GGC-AUGCGGCUACCGGGACCAAGGCUUCAC--GGCCCCCGGCACC GUGC--CACAA-C-AUA-CC-GU-GAGUGUGCAGGAUGU-GACCCGAAAGAUG-GUGAAC UAUGCCUGAUCAGGUUGAAGUCAGG-GGAAACC-CUGAUGGAGGACCGA--AGCAGUUCU -GACGUGCAAAUCGAUUGUCAGAAUUGGGCAUAGGGGCGAAAGACCAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGAGC-A--------------- -------------------------------CG-------------CAACGUUU--CGAA UC-CU--------------------AUUCUUAUCUGGUAAAGCGAAUGAUUAGAGGCC-U UA--GGUUC-G--AAA--UGAUCU-UAACCUAUUCUCAAACUAUAAAUGGGUA-CG--U- A---CCA-UAGCAU---UC-UUG-CAU------------------GAUG-C-U----G-- -UUG-CAAACGUUGGUAAACGCCGGGCCGUCCCCUGUCAGGGCGUGCCACGGCGU-AGAA -GAU---AUCU--GU--G-UGCUU-AGU-GGG-CCAA-GU-UUUGG-UAAGCAGAAC-UG -GUGCUG-UGGGA----UGA--ACCAAACGUAA--UGUUACG--GCGCC--UAAAUAA-A C-G-AC-G-CAUC-AUAGA-UACC--AUG-AAAGGUGUUGAUUGCUACAGACAGCAGGAC GGUGGACAUGG-AAGUUGUCAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAGCAAUUAGCCCUUAAAAUG-GAUGGCGCUU-A-AGUCG---UUU--------GCC--U AUA-CAUUACC--GUG---G--C----GCACA-------------AGU-G---------- ----GGGCA--------------------------------------------------- ------------------------------------------------------------ ----------------------CGCCUCGAGCGCGUC----------------------- -----UGCCC-----UU--GAG---------G-CG-C-C-A-CG-A--GUAGGA----GG ---G-UCUG-GUGG-UGU------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGUGCCU--G-GCGU-AA-GCC--GACA-U-GGA-GCCGCC-A--CUAGCACAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCGA-A------------------UGAGAUC----- ----------UUGGAU-GACU-GAAGUGGAG-GAGGGUUUCG-UGUCAACAGCAGUUGAA CACGAG------------UUAGCCAA-UC-C-UAA----GCUCUA--UGGGAA--ACCU- ------------------------GAUAUA-U---------------------AUUAAGC AUUUAACCAAAUACAACAACGUAUACCAGCGUGUUGAUGCAACCGAUACGAUAUAUAUUG AAU-----------------------------GAGC---GA-AA-GGGA-AUC-CGG--U UAC----AAUU-CCG----GAGCC-U-GU-U--GGGU-A-UAC--G----UUUG----CA UU-G--GCGUC--------CC------------------------------------AUA CCGGCAAC-----------------------------GGU-------AGCGC---C-UUU ------GUA-A--UC-A--UGGCAACAU-G--AAUCCUUUUC-UUCG-A-GA-AGCCA-A CAAG----AGAUA-UC-GG-A-AGAG------UUCUCUU-------UUC-UGU---UU-- -U------ACA------GU-C------A------C--------A---CUA---G--CCAU G-G------A---AG-U--C--U-----U--UCA-U-AGA-GAGAU-AU--GG----U-U -G-GA--CAGG-C--U--G-G--U-AG-A-GCA-UGGUA-U------------------- ---------UAAA----------------------------U-U--GC-UGU--GU---C GA-UA-UUCU----CU-U--C-U-UGGACCUUGAAA-A-UCGAAGACUG--GGG------ --------------------------CACGCAA--------------------------- -A--CU-C-CCA--AC-A-GCUUGUACC-GAAUCCGCAGCAGGUCUCCA-AGG-UUUAGA -G-UCUCUAG-UC-GA-UAGA-UUAAUGUA-GGUAAGGGAAGUCGGCAAAU-UAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UG--A-AG-ACUGGGA-UG-ACUCG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GGCUAUA---CC-C-U----C-C-C-GG---G--G---------------- ------U---U-CGC-C-GC-GG--GUGC---C-GGC-CCGC-CU---C-GCGC--G--- ------------------------------------------------------------ -----------------------------------------------------------G GUG--------CCU-C--GG-UC-C-------------------C-CG---GGGU-C-C- ---------------------------------------------G-G-G------GUU- -U-GCCUCAAC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCGGUC---C--G--G-GC---CGUU-UCGU-G ----UGG--U-GU---UCGC---------------------------------------- ------------------------------------------------------------ -------------------------------GC---ACCG--C---CGG--CG-GUC--- -GCC-GG-G-G--C-C--GC-----UG---------------CAG---UCA-U-CAA--- UAAA--CAG-U-CAAU-UCAGAACUGGCACGG-CUGAGGGAAUCCGA-----CUGUCUAA UUAAAACAAAGCAUUGUGA-UGGCCU--CA---A-A------------AGGUGU-UG-AC ACAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAC-GUGAA-------------GAA A---------------UUCAA-GCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--UCUGUCCCUA-UC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGAAACACUAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCCGGC AUUGUAAGGCGAUAUAAGAGGUGCAGAAU-AGGUGGGAG-CC-G--G------GGU---- ---A-------------------------------------------------------- ------------------------------AAACAUUACC-------UCC-CCGG--CA- CCAA-UGAGAUA-CCACCACUCUUACUGUUGCCUUACUUA-CAU-G--AUCA--GG--UG GA-----------------------A-C--A-AGUGCCAA-------GGUUAUUGCAAC- -CU--CCUGGCA--U--A-A--GGUUUCUUGUUCAGCGUUCAGUCAUGUCGUCAUUCCUG GCCACAAGGCAGAAGACCGAGCCUGCGGUCAUCGCGUCCGUUGCGCGGCUCCCGGGUGUG CGUUCCGGCCGGGUGCGUUCGCGGCUGCCCCAGUAGGAUCCCG----------------- -----------------------------------------------------UCCGGU- --------------------------------------------------UUGGGUUCGC GUGCGGGCCACGGCCGCAGUUUUGCUCAACUU---UCACACCGUACGC------------ ----C--GAU---G------------------ACAGU-AAGACAUC-------------- ----------------UGG--AU-------------------ACU-CC-AAGUC-AUGGA -CAG-UGCCAGGUGCGGAGUUUGACUGGGGCGGUACAUCUCCAA-AACAAUAAC-GGAGG UGUCCAAAGGUCAGCUCAGUGUGGACAGAAACCACACGCU-GAGCAU-AAGGACAAAA-G CUGGCUUGAUCU-CGAUGUUC-A---GUACAUAUUGAGACAGCGAAAGCUAGGCCU-CAC G-AUCCUUUU-------------------------G--G------UUUAAA-GAG-UU-- ----------------------------UUUAGCAAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCCGCCAAGCGUUCAUAGCGACGUGGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAAAAUUCACAAAGCGUAGGAUUGUUCACCCU UUCAAG-GGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --GUG--UGC------------------------------------------GAACGAAC ACGAACGCUAUC-UUAACGGAAA--UGCUGUGCAGUACGAGAGGAACCACAGCUUCGAAC CAA-UGGCUCA-AUACCUAGUUC-GACC-GGAC-UU--UGGUAUAACGCUA-C-GUUCGU --U-GGAUUAUGCCUGAACGCCUC--U-AAGGUCGUAACC------AAA-CCG--AG--- ----CUGAU---------------------------AG--UGUCUCC----UU-A--U-- A--GGUCG-UCGGCGAUCAUGUGGCAAAAAACCUACAAGACCUGCUAGCGUGAUCUCACG UUGGCAUCUUAUUGCAUGCACGCAGACAAAGCCCCCGCGCGCGCACCAUACAGCAAGUAU CUAAGAUACUGGAACGCUGGUGGCGCUGCUCAGCAUCA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AUAU AUGAUUUCG-AUAC----CUGAGACC----CCCU--A-CAAACGAUAG-GU--UUACAGG CUGGGAGUUGCGAG-UUGCAGAGAGG--U----------------GUAC---AUUUC--G -AUCCUC------AG---------UC------G--UU----------UC--UGUUGUCGA CGGGUCUA >Anolis_carolinensis --------------------CUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-AUGUGAAUUGCAGGACA-CA-UU--GAU CAUCGACACUUCGAACGCACUU-GCGGCCCCGGG-UUCC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------CGC-C UGUCUGAGCGUCGC---------------------------------------------- ----UCGCGACCUCAGAUCA-GACGUGGCG-ACCCGCUGAAUUUAAGCAUAUUAGUCAGC --GGAGGAAAAGAAACUAACCAGGAUUCCCUCA-GU-AAC-GGCGAGUGAACAGGGAAG- AGCCCAGCGCCGAAUCCCCGU--CCCGCG-GC-GGGGCGCGGGAAAUGUGGCGUAC---- ----------------------------GGAAGACCC----------------------- ------------CCUCCCCGGC--GCCGCUCCCUCGGGGGG------CCC-AAGUCCUUC UG-A--------UCGAGGCA---C-AGCCCGCGGACGGUGUGAGGCCGGUAGCGGCCC-C -CG-GCGCG---------U----C-GGGACCGGGUCUUCUCGGAGUCGGGUUGCUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGU-CGA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGCCCGCGCAGUCCGCC CGG----AGGAUUCAAC-CCGGCGGGC---CGUCGUCGGCCGCGCCGGGCG---C---GC GGAUCCCCCCCCCGCCCCGGACCCACC--------------------------------- ------------------------------------------------------------ -----------------------------------------UCGGGGAAGGGGUUCCCGG GAGGGGACCGCC-GCCCGGGCGG-AGCCGGCCCCCGUCGGGCGCAUUUCCGCCGG-GGCG GUGCGCCGCGAC-CGGCUCCGGGUCGGCCGGGAAGGCCCC-----GGUUCG----GGCAG GUGGCCCG---------------------------------------------------- -------------------------------------------CCGCCCUC--GCCCG-- ---------GCGG----------------------------------------------- ------------------------------------------------------------ CGGGUGUUACAG-CCCC---------CGGGCCUCAG-----C-C-AUCG----------- -----------CC-GCAUCCCGGGGCCGAGGGA--GA-AG--ACCGCCGCCGCGCCC--- UCCCCC---------CGCC-GGCCCCCCGUCC--------C------------------- -------------UCCCCC-UCGCGGG-----------GGCGGGCGGCGCGGG--GG--- ---------CCUCCGCGC---------GGGGGA--CGGGCCCCCCCG-CUC------CCG -GCGCGACUGUC------------------------------------------------ ----------------------------------------------------------AA CCGGGGCGGACUGCCCUCAGU-GCGCCCCGA-------CCGCGUCGCGCCGCCGGGC--- -----------------------------------------GGGGAGGCGCCACG-CCGG GCGCCCGGGGUCCGCGGCGACGUCGGCCCCCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CACGCGCGCGA---GUCGG--AGG--C-UGA------GCGCGAA-- --------AGCC---CCGCGGCGCAAUGAAG-GUGAGG--------GCCGG-C------- -------GCG----------------C-GCCG-GC-CGA------------------GGU GGGAUCCCGUGUC-C---G--C----------C-G------CCG--A------------- --------------------G----C--G--G--G----------GGGCGCACCACCGGC CCGUCUC---G---CCC----------------------GCCCC-------------G-- --UC--G-GGGAGGUGGAGC-GU-GAGCGCGCGUGCUAG-GACCCGAAAGAUG-GUGAAC UAUGCCCGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCGUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- ----------------------------CGUC------------------CGUC--CGU- ---CGC-------------------AGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCCU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--GCCGCCC-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUCGAUCUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCCAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCGACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUCGCGG--G--C---------------------------------- ------------------------------------------------------------ -------------GAUGCGGG--------------------------------------- ------------------------------------------------------------ CCGCGGGGGC-----UA----G---------GCCG-C-G-A-CG-A--GUAGGA----GG ---GCCGCC-GCGG-UGG------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCCUAG--G-GCGC-GG-GCC--CGGG-U-GGA-GCCGCC-G--CGGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UAA----GAGAUA--GGCGAG--CGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUC-----G-CCC-U--CGG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---GCGG-C-GGA--G----A--C----GG -G-C---------------G---C----------------------------------CG CGA--------------------------------------------------------- ---GGCGUC-CAG-U-G--CGGUAACGC-G----A-CCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUC---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCCU G-G------A---AC-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GCGC-C--U--U-G--G-AA-A-GCG-UCGCG-G------------------- ---------UU-CC-----------------------------G--GC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-CGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UAGA-ACAACGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UG--A-GG-GCUGGGC-CG-GU-CGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCUGGGGCG-C--GAA---GC-G-G-GG---C--UG-G-GCGC-GC-GCC- -GC-G-G---C-CGG-A-GG-AG-GCG--------------------------------- -----------------CCCGCUCCCCCCCGUGCGCCCCGCGUG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------CCGGGGGGC-----GCGGCGGCG ACUCUGGACGCGCGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGCGGC--- ----------------------------CGGGCCCUCCCCCC------------------ ------------------------------------------UCGGCGGGGGACGGGUCG GG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CC-G--GCGUCCC---------------G-CCU---CGG-C-CGGCGC CUAG--CAG-C-CGAC-UUAGAACUGGCGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCG-CG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC CCUGUGAAGAGACAUGAGAGGCGUAGAAU-AAGUGGGAGGCC-C---------------- ------------------------------------------------------------ ----------------------------------GCCCG------------UCGGGCCG- CCGG-UG-AAUA-CCACUACUCUGAUCGUUUUUUCACUUA-CCC-G--GUGA--GG--CG GG---------------------GGG-G-CG-AGCCC--------------CGAG----- --------GGG-C-U--C-U-CG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CUUCUGGCU- ------------------------------------------------------------ --------------------------------------------GCAA------------ ----G---CG-C-CCG-----------------------GCG------------------ -CGG--G-C-----C-GGG--CGC------------------GAC-CC-GCUCC-GGGGA -CAG-CGUCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AAGCGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGCG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUACGAAUACAGACCGUGAAAGCGGGG-CU-CAC G-AUCCUUCU-------------------------G--AC-----UUUUUG-G-G-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-GGC-------------------------------------------------- ------GUCGUU-GCGCUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGGGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------CCC-CUAAAGG--- GA--ACGAU---------------------------AC--C-GCAGC----GC-C--G-- A--GGA-G-CCUC----------------------------------------------- ------------------------------------------------------------ ------------GG--UGGGCC-CGGAUA---------------------GC-------- ------------------------------------------------------------ ----CGGGCCGG--CC-CU-----------------C----------------------- ------------------------------------------------------CCGGGG GCCGGCCCCGGUG-----CG-GAGAG---CCGU--C-C-GUC---UCG-GG--AGCGGAG CGCGGCCGGAAGGG--GGCCG--CC-U-C-UCGCC-CGUAGC-G-CAACGC--A-CGUUC GCGGG-G-AA-C-CC-GGCG-CUAAAU---CAUUC-G-UAGACGACCU-GA-UUCUGGGU CGGGG-UUUCGUACGUAGCAGAGCAGCU-----------------CCCUCGCUGCGA--- --UCUAU--U--GAAAGUCAGCCCUCG---A--CAC-AA-GC------------------ -------- >Arabidopsis_thaliana -------------AAAACGACUCUCGGC-AACGGAUA-UCU-CGGCU-CUC-G--CAU-C GAUGAAGAACGUAGC-GAAAUGCGAUACUUG-GUGUGAAUUGCAGAAUC-CCG-U-GAAC CAUCGAGUCUUUGAACGCAAGU-UGCGCCCCAAGCCUUC---------------U----- ----------GGCCGAG------------------GGCA--------------------- -------------------------------------------------------CGU-C UGCCUGGGUGUCAC---------------------------------------------- ----AAGCGACCCCAGGUCA-GGCGGGAUU-ACCCGCUGAGUUUAAGCAUAUCAAUAAGC --GGAGGAAAAGAAACUAACAAGGAUUCCCUUA-GU-AAC-GGCGAGCGAACCGGGAAG- AGCCCAGCUUGAAAAUCGGA-CGUC-------UUCGGCGUUCGAAUUGUAGUCUGG---- ----------------------------AGAAGCGUC----------------------- ------------C------UCA--GCGACG----GACCGGG------CCU-AAGUU-CCC UG-GA-------AAGGG------G-CGCC-AGAGAGGGUGAGAGCC-CGUCGUGCCCGG- -AC-CC-UG---------UCGCAC-CACGAGGCGCUGUCUACGAGUCGGGUUGUUU---G GGAAUGCAGCCCCAAU-CGGGCGGUAAAUUCCGUCCAAGGCUAAAUACGGG-CG-AGAGA CCGAUAGC-GAA-CAAGUACCGCGAGGUAAAGAUGAAA-AGGAC-UUUGAAAAGAG-AGU CAAAGAGUGCUUGAAAUUGUCGGGAGG---G-AAGCG-GAUGGGGGCCGGCGAUGCGUCC UGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------UCGGAUGCGGAACGGAGCAAUCC-------GGU- ----CCGCCGAU-CGAUUCGGG------------------------------------GC GUGGACCGACG--CG--------------------------------------------- --G-------------------------------AUUACGGUGGCGGC------CUAA-- ---------GC---CCGGGC--UUUU-----GAU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ACGCUUG--- UG--------------------------------------GAGACGUC--------GCUG CCGUGAUCGU-GGUCUG-CAGCA---------------C---------------GCGCCU AACGG-C--GUGCCUCGG---------CAUCAGC--GUGCU----------------CCG -GGCG------------------------------------------------------- -----------------------------------------------------------U C------GGCCUGUGGGCU----------------------------------------- ------------------------------------------------------------ ----------------------------CCCCAUUCGACCCGUCUUGAAACACGGACCAA GGAGUCUG-A----CAUGUGUGCGA---GUCAAC-GGG--U----------GAGUAA--- --------ACCC-G-U-AAGGCGCAAGGAAG-CUGAUU---------------------- ---------------------------------------------------------GGC GGGAUCC-----------------------------------UCGC-------------- --------------------------------------GGGUGCACCGCC----GACCGA CC-U-U----G---AUC----------------------UUCU----------------- --GA--GAAGG-GUUCGAGUG-U-GAGCAUGCCUGUCGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGCGGGGUAAAGCCAGA-GGAAACU-CUGGUGGAAGCCCGC--AGCGAUACU -GACGUGCAAAUCGUUCGUCUGACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGAGC-U--------------- -------------------------------CG------------------GAC--G--- ---CG--------------------AGUUCUAUCGGGUAAAGCCAAUGAUUAGAGGCA-U UGG-G-GGC-G--CAA--CGCC-U-CGACCUAUUCUCAAACUUUAAAUAGGUA-GG--A- C---GUG-UCGGCU---GC-UUUGUU-------------------GAGC-C-G----U-- -C-A-C--------------------------------------------------ACGG -AAU---CG-A--GA--G-CUCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGGAAGCCG--GGUUACG--GUGCC--CAACUG--C G-C-GC-U-AAC--CUAGA-ACCC--ACA-AAGGGUGUUGGUCGAUUAAGACAGCAGGAC GGUGGUCAUGG-AAGUCGAAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCCGAAAAUG-GAUGGCGCUU-A-AGCGC-----G--------ACC--U AUA-CCCGGCC--GUC---G--G----GG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AAGAGCCAG-------------------------- -------------------------------GCCU-C-G-A-UG-A--GUAGGA----GG ---G-CGCG-GCGG-UC-------------------GC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GCAA AACCUAG--G-GCGC-GAGGC------G-C-GGA-GCGGCC-G--UCGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GGCC-GAAGAGGGG-AAAGGUUCCA-UGUGAACGGCACUUGCA CAUGGG------------UUAGUCGA-UC-C-UAA----GAGUCG--GGGGAA--ACCC- ---------------------------G-U-C--UGA-----UAG-CGC----------- ---------------------------UUAA----------------------------- -----------------G--C-G-A------ACUUC---GA-AA-GGGG-AUC-CGG--U UAA----AAUU-CCG----GAACC-G-GGAC--GUGG-C-G------------------- -----------------------------------------------------------G UU---------------------------------------------------------- --------------G-A--CGGCAACGU-U----A-GGGAGU-CCGG-A-GAC-GUCG-G CGGG----GGCCU-CG-GG-A-AGAG------UUAUCUU-------UUC-UGU---UU-- -A------ACA------GC-C------U------G--------C---C----CA--CCCU G-G------A---AA-C--G--G-----C--UCA-G-CCG-GAGGU-AG--GG----U-- -C-CA--GCGG-C--U--G-G--A-AG-A-GCA-CCGCA--------------------- ---------CG-UC-----------------------------G-CGU-GGU--GU---C CG-GUGCGCC----CC-C--G-G-GCGCCCUUGAAA-A-UCCGGAGGAC--CGAGUGC-- ------------------------------------------------------------ -C--GCUC-ACG--CC-C-GGUCGUACUCAUAACCGCAUCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-UC-GA-UGGA-ACAAUGUA-GGCAAGGGAAGUCGGCAAAA-UGGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-UG--A-GG-GCUGGGC-UC-GG-GGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------UCCCAGUUC-C--GAA----C-C-C-GU---C--G--G-C-U--GU-CAG- -C--G-G---A-CUG-C-U--CG--AG-C-U-G-C------------------------- ------------------------------------------------------------ -----------------------------------------------------------U UC-C----------------------------------GCGG-CG-AG---AG-C-G-G- G-UC-GCC-GGCU-GC-C------G-G---CCG--G-G------GGAC-G------ACU- -G-GGAACG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCUCU---------------------------- ---------------CUCG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------G--G-A--GCU--U----------------U-CCC---CGG-G-CGU--- CGAA--CAG-U-CAGC-UCAGAACUGGUACGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUUGCGA-UGGUCC--CU---G-C------------GGAUGC-UA-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUG-UC-UAC-UAUCCAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCCGAC UUUGUGAAAUGACUUGAGAGGUGUAGGAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UUCG----------------G--CG- CAAG-UGAAAUA-CCACUACUUUUAACGUUAUUUUACUUA-CUC-C--GUGA--AU--CG GA-----------------------G-GCCG-GGGU----------------ACA----- ---------AC-C-C--C-UG-U------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUUUGGUC- ------------------------------------------------------------ --------------------------------------------CCAA------------ ----G--GCU---C--G---C-----------------UUCG------------------ ------G-------C-GGG--UC-------------------GAU-CC-GGGCG-GAGGA -CAU-UGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AAAGAUAAC-GCAGG UGUCCUAAGAUGAGCUCAACGAGAACAGAAAUCUCGUGUG-GAACAA-AAGGGUAAAA-G CUCGUUUGAUUC-UGAUUUUC-A---GUACGAAUACGAACCGUGAAAGCGUGGCCU-AUC G-AUCCUUUA-------------------------G--A------C-UUCG-GAA-UU-- ----------------------------UGAAGCUAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUUCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGUGUUGGAUUGUUCACCCA CCAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG--C-C-------------------------------------------------- ------CGCGUC-GCGAUAGUAA--UUCAACCUAGUACGAGAGGAACCGUUGAUUCGCAC AAU-UGGUCAUCGCGCU-UGGUU-GAAA-AGCC-AG--UGGCGCGAAGCUA-CCGUGCGC --U-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------GGG-CUA--GA--- -A--GCGAC---------------------------GC--AUGCG------CC-C--G-- C--CGC-C-CGAU----------------------------------------------- ------------------------------------------------------------ ------------UG--CCGACCCUCAGUA---------------------GG--A--G-- -C------------------------UUA--------------------------G-G-- C--UCC-AA--AGGCACGUGUCGUUGGCUAA-----------------GU-CCGU--U-C --GGC--------------GGAACG--------------------G----U--CG--UU- C-GGAC------------------------------------------------------ ---------CGC--CUUGAAUUAUAAUUACC----------------------------- ACCGAGCGG-CGGG-----UA-GAAUC---CUUU--G-CAGACGACUU-AA-AUACGCGA CGGGGUAUUGUAAG-UGGCAGAGUGG--C-C--------------UUGCU--GCCAC--G -AUCCAC--U--GAGAUUCAG-CCCUU---U-GU-CGCU-AAGAUU-CG--A-------- -------- >Caenorhabditis_briggsae -----------------CUAGCUUCAGC-GAUGGAUC-GGU-UGCAU-CGA-G--UAU-C GAUGAAGAACGCAGC-UUGCUGCGUUACUUA-CCACGAAUUGCAG-ACG-CU--U-AGAG UGGUGAAAUUUCGAACGCANAG-CACCGACUGGG--UC----------------U----- -----------CCAGUC------------------GGUA--------------------- -------------------------------------------------------CGU-C UGGUUCAGGGUUGU---------------------------------------------- ----UAUCAACCUGAACUCA-GUCGUGAUU-ACCCGCUGAACUUAAGCAUAUCAUUUAGC --GGAGGAAAAGAAACUAAAAAGGAUUCCCUUA-GU-AAC-GGCGAGUGAAACGGGAUG- AGCCCAGCGCCGAAUCGAUCAG-CCUAUG-GU----UGCUUCGAAAUGUGGCGUAU---- ----------------------------AGGUGUAGU----------------------- ------------C-----UUCC--AGCAGU--GUCGUGAGU------CCG-AAGUCCUUA CG-A--------UUGAGGCCA--U-AGACCAGAGAGGGUGCGAGUCCCGUCCUGGAUUGC -GA-UGCUG---------U----U-GGUUCGAUUGCUCCUUGGAGUCGGGUUGCUU---G AAAGUGCAGCCUAAAG-UGGGUGAUAAACUUCAUCUAAGGCUAAAUAUUGA-CU-CGAUU GCGAUAGC-GAA-CAAGUACCGUGAGGGAAAGUUGCAA-AGGAC-UUUGAAGAGAG-AGU UCAAGAGAACGUGAAAUCGCUGGAGUG---G-AA-CC-GGAGACAGUUGAUGUUGCUUGG --------AGACA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGUU-------UGG- ----UGGCUGGU-CGCUUAGUUGU--------------------------------GAUC GUCGCCGGAUG--UC--------------------------------------------- --GU-UUCCUA---UGCU----------ACGCCGACGGCGUUGGUCGCUCGUUCUGGCC- -CGAUAGUG---UUGCCCAG--CUCG-----CAA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAGUCGG--- UGUC------------------------------------U------------------- ---------------UGUUAUCGGUCG-------UU--G---------------GUUCGU GGUGG-C--UAG------------------------------------------------ ---CGUUUA------G--------------U----U------------------------ --------------------------------------------------------ACGC U------AGUGUGUGUGACGUCGG------------------------------------ ------------------------------------------UGU--------GA-AAG- ----UCGACG------------------ACGUUUCCGACCCGUCUUGAAACACGGAUUGC GGAGUGCU-U----GUCUACUGCGA---GUCAAA-GGG--U----------GUUAAA--- --------ACCU-U-G-C-GGCGAAAUGAAA-GUGAAG--------GUCAG-U------- ------CUUGA-----------------AUUG-GC-CGA------------------CGU GGGA-UCG--G-U-G---C--U----------C---------CUCG-------------- -----------------G--A----G--U--G--C---UGC-GCACCACG----GCCCUG UG-CGU----G---UCA----------------------CUU------------------ --GU--GACUGUG-CAGAGG-UU-GAGCAGUUGGCAAAC-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGCAGGAUGAAGCCAGA-GGAAACU-CUGGUGGAAGUCCGU--AUCGGUUCU -GACGUGCAAAUCGAUCGAUAGACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCUUCCGAAGUUUCCCUCAGGAUAGCUGGAUC-U--------------- -------------------------------------------------CC-G---GC-- -------------------------AGUUAUAUUCGGUAAAGCUAAUGAUUAGAGGCC-U UGG-G-GAC-G--UAA--UGUCCU-CAACCUAUUCUCAAACUUUCAAUGGAUA-UG--A- A---GUU-GCAGUU---UC-UUUAGU-------------------GAAC-U-G----U-- -C-A-A--------------------------------------------------CGUG -AAU----G-C--GA--G-GUCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGCUG-UGGGA----UGA--ACCAAACGUGG--AGUUAAG--GUGCC--UAACUU--C U-C-GC-U-CAU--G-AGA-CCCC--AUA-AAAGGUGUUGGUUGAUAUUGACAGCAGGAC GGUGGCCAUGG-AAGUCGGUAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUU-A-AGCGA---GAG--------ACC--U AUA-CUCCGCC--GUU---G--C----GG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AUGUGC-------------------------GU-U GUCUAGC-GC-----CA----G---------GCCG-U-A-A-CG-A--GUAGGA----AG ---GUCGUG-GCGG-UU-------------------GC-U-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGGCUAU--GAGCGU-GG-GCU--CGGC-U-GGA-GCUUCC-G--UCAGUGCAGAUCG-U AAUGG-UAGUA-GCA-A--AU-AUUCAA-G------------------UUCGAUC----- ----------CUUGAA-GACU-GAAGUGGAG-AAGGGUUCCA-CGUGAACAGUAGUUGGA UGUGGG------------UCAGUCGA-UC-C-UAA----GGUACU--GGCGAA--CGCC- ---------------------------U-UGUAUCAUCGG--UGG-CG------------ ------------------AAAAGCUUGCUUU----------------------------- -----------U--GG-UC-C-CCG-----UUUGUC---GA-AA-GGGA-AUA-GGG--U UAA----UAUU-CCC----UAACU-G-AGAU--GCAA-A-GAU--U----G--U----G- ----------------------------------------------------------UU CUU------------------------------------------------------CGG ----AGCAC-AAG-C-G--CGGUAACGC-A----U-UCGAAC-UUGG-U-UA--GUCGC- UCAA----AGA-C-CG-AGCU-AGAG------UUUUCUU-------CUC-UAG---UU-- -A------AGG------AA-C------G------G--------A---C-----U--CCCU G-G------A---AU-U--G--G-----U--UCA-G-CCA-GAGAU-GG--GG----AC- -G-UU--GUUU-C--C----G--A-AA-A-GCA-CCGCG-G------------------- ---------UU-UC-----------------------------U--GU-GGU--GU---C UC-GUG-CUC----UU-U--G-AACGGCCCUUAAAA-C-ACCAAGGGAG--GCU------ -----------------------------AUUA--------------------------- -A--UU-U-GCA--CU-C-AAUCGUACCGAUAUCCGCAUUAGGUCUCCA-AGG-UGAACA -G-CCUCUAG-UC-GA-UAGA-AUAAUGUA-GGUAAGGGAAGUCGGCAAAC-UAGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-CA--G-UG-GUUGGAA-CG-AU-UGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------CCAGUUG---G--U-U----G-A-U-G----C--U-UG-U-CC-GG-CGC- -U--A-U---U-CUG-U-C--UG--CU-U-G-A-UG------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UC-UCG----------------------------GG-CUGAU-GG-CG---GA-C-U-A- GUGAUAGU-GCUU-GC-UU-----G-----U-G--G-A-------C-G-C------UUU- CU-GGUGU---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GUGCUA---G--G-------------------- ----------------AC------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CUC-GGU-U----- -C------U-A--G-U--AUC--C----------------U-GAU---CGC-U-CAU--- CUAA-ACAA-C-CGUA-CUGGAACCGGUACGGACUCAGGGAAUCCGA-----CUGUCUAA UUAAAACAGAGGUGACAGA-UGGUCC--UU---G-C------------GGACGC-UG-AC UGUCACUG-AUUUCUGCCCAGUGCUC-UGAAUGUUAAA-UCGUA-------------GUA A---------------UUCGA-GUAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUU-UAAUUGUUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCU--ACUGUCCCUA-AC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAAAAAUAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC AUUGUGAAGAGUCAUGAGAGGUGUAGCAU-AGGUGGGAG-AC------------------ ------------------------------------------------------------ ----------------------------------UUCG---------------GU--CG- CCGG-UGAAAUA-CCACCACUUUCAUCGACUCUUUACUUA-UUC-G--GUUA--AA---A GA-----------------------G-A-AU-UGGCU--------------UCAC----- --------GGC-C-U--U-U-UU------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UCGAAGCA- ------------------------------------------------------------ --------------------------------------------UUAA------------ ----GCGGAG---C--C---AU----------------UUUA------------------ ------U-G-----G-CAC--CGU------------------GAC-UC-UCCUC-GAAGA -CAG-UGUCAAGCGGGGAGUUUGACUGGGGCGGUACAUCUAUCA-AAUCGUAAC-GUAGG UGUCCUAAGGCGAGCUCAGAGAGGACGGAAACCUCUCGUA-GAGCAA-AAGGGCAAAA-G CUUGCUUGAUCU-UGACUUUC-A---GUACGAGUACAGACCGCGAAAGCGUGGCCU-AUC G-AUCCUUUU-------------------------A--AU-----C-CUGA-UUG-UU-- ----------------------------UCAGGUAAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUCCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGCGAAGCAGAAUUCGCCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --UUGA-CUU-------------------------------------------------- ------GUUAUU-GCGAAAGUAA--UCCUGCUUAGUACGAGAGGAACAGCGGGUUCAAAC AUU-UGGUUCAUAGACU-UGAUC-GACA-GAUC-AA--UGGUCUGAAGCUA-CCAUUUGA --G-AGAUUAUAACUGAACGCCUC--U-AAGUUAGAAUCU------CGC-CUUGUCA--- --AGGCGAA---------------------------AA--UUUCUUG----CU-U--C-- C--CGG-U-GUC------------------------------------------------ ---------------------------------------GG-GAGGCAUCU--------- ------CUA---UC--UC------------------------------------------ ---------------------------GUG---------------------G---C-A-- A--CAC-GA--GAGCUUAUGCCCUA-UG-U-----AUGGCCUUGG---CU-UCGU--A-G -UGAA-CUC----------UGCGAA--------------------G----C--UUGCCAA C-GCCA------------------------------------------------------ ---------------------------------------GAUCACUCUGGUUCA------ -AUGUCGGG-GCGC-----UA-AAUC----ACUU--G-CAUACGACUUGGU-CUCUUGGU CAAGGUGUUGUAUU-CAGUAGAGCAGUCC-U--------------CUUAU--ACUGC--G -AUCUGU--U--GAGACU-AU-C-CUU---U-GA-UUGA--------------------- -------- >Caenorhabditis_elegans -----------------CUAGCUUCAGC-GAUGGAUC-GGU-UGCAU-CGA-G--UAU-C GAUGAAGAACGCAGC-UUGCUGCGUUACUUA-CCACGAAUUGCAG-ACG-CU--U-AGAG UGGUGAAAUUUCGAACGCAUAG-CACCAACUGGG--CC----------------U----- -----------CCAGUU------------------GGUA--------------------- -------------------------------------------------------CGU-C UGGUUCAGGGUUGU---------------------------------------------- ----UCUCAACCUGAACUCA-GUCGUGAUU-ACCCGCUGAACUUAAGCAUAUCAUUUAGC --GGAGGAAAAGAAACUAAAAAGGAUUCCCUUA-GU-AAC-GGCGAGUGAAACGGGAAG- AGCCCAGCGCCGAAUCGAUCAG-UCUUUG-GC----UGCUUCGAAAUGUGGCGUAU---- ----------------------------AGGUGUAAG----------------------- ------------U-----UUCC--AGCAGU--GUCGUAUGU------CCG-AAGUCCUUA CG-A--------UUGAGGCCA--U-AAACCAGAGAGGGUGCGAGCCCCGUUCUGGAUAGC -GG-CACUG---------U----U-GGUUCGCUUGCUCCUUGGAGUCGGGUUGCUU---G AAAGUGCAGCCUAAAG-UGGGUGAUAAACUUCAUCUAAGGCUAAAUAUCGA-CU-CGAUU GCGAUAGC-GAA-CAAGUACCGUGAGGGAAAGUUGCAA-AGGAC-UUUGAAGAGAG-AGU UCAAGAGAACGUGAAAUCGCUGGAGUG---G-AA-CC-GGAGACAGUUGAUGUUGCUUGG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AGACAAGCU-------UGG- ----UGACUGGU-CGCUUAGUUGU--------------------------------GAUC GUUGCCGGGUG--UC--------------------------------------------- --GU-UUCCUA---UGCU----------ACGCCGACGGCGUUGGCUGCUCGUUCUAGCC- -CGACAGUG---UUGCCCAU--CUCG-----CAA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAGAAGG--- UGUC------------------------------------U------------------- ---------------UGCUGGCGGUAG-------UG--G---------------GUUCGU GGCGG-C--UAG------------------------------------------------ ---CGUUUA------G--------------U----U------------------------ --------------------------------------------------------ACGC U------AGUGUGUGUGACGUCGG------------------------------------ ------------------------------------------UGU--------GA-AAG- ----UCGACG------------------ACGUUUCCGACCCGUCUUGAAACACGGAUUGC GGAGUGCU-U----GUCUACUGCGA---GUCAAA-GGG--U----------GUUAAA--- --------ACCU-U-G-C-GGCGAAAUGAAA-GUAAAG--------GUCAG-U--C---- --------UCG-----------------AAUUGGC-CGA------------------CGU GGGA-UCU--G-U-G---U--U----------C---------UUCG-------------- -----------------G--A----G--U--G--C---AGC-GCACCACG----GCCCUG UG-CGU----G---UCA----------------------CUU------------------ --GU--GACUGUG-CAGAGG-UU-GAGCAGUUGGCAAAC-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGCAGGAUGAAGCCAGA-GGAAACU-CUGGUGGAAGUCCGU--AUCGGUUCU -GACGUGCAAAUCGAUCGAUAGACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCUUCCGAAGUUUCCCUCAGGAUAGCUGGAUC-U--------------- -------------------------------------------------CA-G---GC-- -------------------------AGUUAUAUUCGGUAAAGCUAAUGAUUAGAGGCC-U UGG-G-GAC-G--UAA--UGUCCU-CAACCUAUUCUCAAACUUUCAAUGGAUA-UG--A- A---GUU-GCAGUU---UC-UUUAGU-------------------GAAC-U-G----U-- -C-A-A--------------------------------------------------CGUG -AAU----G-C--GA--G-GUCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGCUG-UGGGA----UGA--ACCAAACGUGG--AGUUAAG--GUGCC--UAACUU--C U-C-GC-U-CAU--G-AGA-CCCC--AUA-AAAGGUGUUGGUUGAUAUUGACAGCAGGAC GGUGGCCAUGG-AAGUCGGUAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUU-A-AGCGA---GAG--------ACC--U AUA-CUCCGCC--GUU---G--C----GA-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AUGUGCGUUGUCUAGCGCCAG------------------- -------------------------------GUCG-U-A-A-CG-A--GUAGGA----AG ---GUCGUG-GCGG-UU-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGGCUAU--GAGCGU-AG-GCU--CGGC-U-GGA-GCUUCC-G--UCAGUGCAGAUCG-U AAUGG-UAGUA-GCA-A--AU-AUUCAA-G------------------UUCGAUC----- ----------CUUGAA-GACU-GAAGUGGAG-AAGGGUUCCA-CGUGAACAGUAGUUGGA UGUGGG------------UCAGUCGA-UC-C-UAA----GGUACU--GGCGAA--CGCC- ---------------------------U-UGUAUCAUCGG--UGG-CG------------ ------------------AAAAGCUUGCUUU----------------------------- -----U-----A-GUC-C--C-C-G-----CUUGUC---GA-AA-GGGA-AUA-GGG--U UAA----UAUU-CCC----UAACU-G-AGAU--GCAA-A-GAU--U----G--U----GU UC--------------------------------------------------------UU CGGA-------------------------------------------------------- ------GCA-CAA-G-CG-CGGUAACGC-A----U-UCGAAC-UUGG-U-UA--GUCG-C UCAA----AG-AC-CG-AGCU-AGAG------UUUUCUU-------CUC-UAG---UU-- -A------AGG------AA-C------G------G--------A---C-----U--CCCU G-G------A---AU-U--G--G-----U--UCA-G-CCA-GAGAU-GG--GG----AC- -G-UU--GUUU-C--C--G----A-AA-A-GCA-CCGCG--------------------- ---------GU-UU-----------------------------C-UGU-GGU--GU---C UC-GUG-CUC----UU-U--G-AACGGCCCUUAAAA-C-ACCAAGGGAGG-CUA------ -----------------------------UUAA--------------------------- -U--UUGC-ACU--CA-A---UCGUACCGAUAUCCGCAUUAGGUCUCCA-AGG-UGAACA -G-CCUCUAG-UC-GA-UAGA-AUAAUGUA-GGUAAGGGAAGUCGGCAAAC-UAGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-CA--G-UG-GUUGGAA-CG-GU-UGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------CCAGUUG---G--U-U----G-A-U-G----C--U-UG-U-CC-GG-CGC- -A--G-U---U-CUG-U-C--UG--CU-U-G-A-UAC-UU-------------------- ------------------------------------------------------------ -----------------------------------------------------------U CG-G-----------------------G-U--U-GAUGGCGGACU-AG---UG-AUU-G- U-GC-UUG-CUUGCGG-AC-----GCU---UUC--U-G------GUGUGU------GCU- -U-GGACCU--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CGGU----------------------------- ---------------UCUA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------G-U--AUC--C----------------U-GAU---CGC-U-CAU--- CUAA-ACAA-C-CGUA-CUGGAACCGGUACGGACUCAGGGAAUCCGA-----CUGUCUAA UUAAAACAGAGGUGACAGA-UGGUCC--UU---G-C------------GGACGU-UG-AC UGUCACUG-AUUUCUGCCCAGUGCUC-UGAAUGUUAAA-UCGUA-------------GUA A---------------UUCGA-GUAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUU-UAAUUGUUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCU--ACUGUCCCUA-AC-UAC-UUUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAAAAAUAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC AUUGUGAAGAGUCAUGAGAGGUGUAGCAU-AGGUGGGAG-U------------------- ------------------------------------------------------------ ---------------------------------CUUCG----------------G-ACG- ACAG-UGAAAUA-CCACCACUUUCAUCGACUCUUUACUUA-UUC-G--GUUA--AA---A GA-----------------------G-A-AU-UGGCU--------------UCAC----- --------GGC-C-U--U-U-UU------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UCGAAGCA- ------------------------------------------------------------ --------------------------------------------UUAA------------ ----G-CGGA---G--C---CA----------------UUUU------------------ ------A-U-----G-GCA--CC-----------------GUGAC-UC-UCCUC-GAAGA -CAG-UGUCAAGCGGGGAGUUUGACUGGGGCGGUACAUCUAUCA-AAUCGUAAC-GUAGG UGUCCUAAGGCGAGCUCAGAGAGGACGGAAACCUCUCGUA-GAGCAA-AAGGGCAAAA-G CUUGCUUGAUCU-UGACUUUC-A---GUACGAGUACAGACCGCGAAAGCGUGGCCU-AUC G-AUCCUUUU-------------------------A--AU-----C-CUGA-UUG-UU-- ----------------------------UCAGGUAAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUCCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGCGAAGCAGAAUUCGCCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --UUGA-CUU-------------------------------------------------- ------GUUAUU-GCGAAAGUAA--UCCUGCUUAGUACGAGAGGAACAGCGGGUUCAAAC AUU-UGGUUCAUAGACU-UGAUC-GACA-GAUC-AA--UGGUCUGAAGCUA-CCAUUUGA --G-AGAUUAUAACUGAACGCCUC--U-AAGUUAGAAUCU------CGC-CUUGUCA--- --AGGCGAA---------------------------AA--UUUCUUG----CU-U--C-- C--CGG-U-GUC------------------------------------------------ ---------------------------------------GG-GAGGCAUCU--------- ------CUA---UC--UC------------------------------------------ ---------------------------GUG---------------------G---C-A-- A--CAC-GA--GAGCUUAUGCCCUA-UGUAU-----------------GG-CCUU--G-G -CGUCGUAGU-GAAUUC--UGCGAC---------GCUUG------C----C--AA--CG- C-CAGA------------------------------------------------------ ----------------------------------------UCACUCUGGUUC-------- -AAUGUCGG-GGCG----CUA-AAUC----ACUU--G-CAUACGACUUGGU-CUCUUGGU CAAGGUGUUGUAUU-CAGUAGAGCAGUCC-U--------------UUUAU--ACUGC--G -AUCUGU--U--GAGACU-AU-C-CUU---U-GA-UUGA-GU-UUU-UU--G-------- -------- >Cryptosporidium_hominis ------AACA---CCUAACACUUUAAGU-AAUGGAUG-UCU-UGGUU-CUC-A--UAA-C GAUGAAGGACGCAGC-AAAGUGCGAUAAGCA-AUGUGAACUGCAUAAUU-CUA-U-GAAC AAUCAGAUCUCUCAACGCAAAU-GGCAGUAAUUUUAUAU---------------U----- -----------------------------------ACUA--------------------- -------------------------------------------------------UAU-U UAUAUCAGUGUCUAUUGACUACUUCAUAUAA-----------------------UAUAAU GUUUAAAAGACCUGAUAUUA-AGUAAGAUU-ACCCACUGAACUUAAGCAUAUUAUUAAGU --GGAGGAAAAGAAACUAACUAGGAUUUCCUUA-GU-AAC-UGCGAGUGAACAGGAAAG- AGCUCAACAUGAAAAUCAAUAAUAA--UUAUAUUUUAUUAUUGACUUGUAGUAUCU---- ----------------------------AGAAGUAAU----------------------- ------------G------CCA--GUGAAU----UAAUAAA------AUU-AAGUG-UUU UG-GA-------AUAAA------C-CACC-AUAGAGGGUGAAAGUCCCGUCUAUAUUUU- -AUUUUUAA---------UUCACA-UACGGUUUACUAUCAAAGAGUCAUAUUCCUU---G GGAAUGGAGUAUAAAA-UGGGUGGUAAUUUUCAUCCAAAGCUAAAUAUUGA-UG-AGAAA CCGAUAGC-AAA-CAAGUACCGUGAGGGAAAGAUGAAA-AGAAC-UUUGAAAAGAG-AGU UAAAA-GUACCUGAAAUUACUUAAAGG---G-AAGCA-AAUAAAACCUAACAUU------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------UAAAAAGGUAAAUUCUU----------UUA GAAUUGUUAUAGUUUUA----AUAUUUAAAUAUAAGAAAUGA-AUGAGGGAAUGUAUAAA CAUUCAAAG-------------------AAU-------AAUAAU--UUUUAAUAUAUUAU UAUA-----------UU---------AUUGUUAUUCUAAGAUAUUGGU--AUAAAAUAG- ----G------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUUUAUCUGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CAUGUGUGCAA---GUAUAU-AAG--U-A--------AUUAAA--- --------ACUU-A-U-A-UGCAUAAUGAAA-GUGACA---------------------- ---------------------------------------------------------AUU GGGAUUU---U-U-U---U-----------------------UAAAAGA----------- --------------------------------------AAAUGCACCAAU----GACCGA CA-U-UA---A---UUUCAU-------------------UUUUU---------------- -GAA--UUAAA-GUUUGAGU-AU-GAGCAUAAAUGUUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGUAGGGUGAAGCCAGG-GGAAACU-CUGGUGGAAGCUCGC--AGCGAUACU -GACGUGCAAAUCGUUCGUCAAACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGAGU-U--------------- ------------------------------UAU------------U-----UUUAAUU-U -------------------------AGUUUUGUCAGGUAGAGAUAAUGAUUAGAGGCA-U CU--GGGAC-A--UGU--UGUCCU-AGACCUAUUCUCAAACUUCGAAUAGGCA-AG--U- A---CUA-AUAAUU---AC-UUAAU--------------------GAAU-U-A----U-- -U-A-G--------------------------------------------------AAUU -AAU----A-U--UA--A-CUCUU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-AGGGA----UGC--UCCUAACGUUU--AGUUAAG--GUGCC--UAAAUG--U A-U-GC-U-CAU--C-AGA-UACC--AUA-AAAGGUGUUGGUUCAUUUAAACAGCAGGAC GGUGGUCAUGG-AAGUCGAAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUGAACCAGCCCUGAAAAUG-GAUGGCGCUG-A-AGCAU---AUU--------ACC--G AUA-CUAAACC--AUU---A--U----UU-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------UAAUUAUAU-------------------------- -------------------------------AAAA-U-A-A-UG-U--GUAGGA----GG ---G-CGUA-AAAG-UU-------------------GU-U-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGUAUAA--G-AUGU-AA-AUC--UAUA-U-GGA-ACGGCU-U--UUAGUGCGGAUCU-U GGUGG-UAGUA-GCA-A--UU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GACGUGGAG-CAGGGUUCCA-UGAGAACAGUAUUUGGA CAUGGG------------UUAGUCGG-UC-C-UAA----GUGAGA--GGUUAA--CACC- ---------------------------A-A-U--AAAAU---AAA-UUA-UU-------- ---------------------------UUUU----------------------------- -----A-----U--AU-U--U-A-U-----ACUCAC---AA-AA-GGGA-AUC-AGG--U UGA----UAUU-CCU----GAACC-A-GAAU--AUGG-A-UAUUU--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------AU-A--UGGUAACAU-A----A-AAGAAC-UCUA-A-AA-CACAA-G UAUA----AAUCC-CG-AA-U-AGCG------UUAUCUU------UUGC-UAU---UU-- -A------ACA------AU-C------U------A--------U---U-----A--CCAU G-G------A---AU-U--A--G-----U--UCA-G-CUA-GAGAA-AU--GG----U-- -U-AU--AUGA-U--U--G-G--A-AU-A-GAA-UUCUC--------------------- ---------UU-UG-----------------------------U-GGA-AUU--UU---C -G-GUGCAUU----UA-U--A-A-UUGUCCUUGAAA-A-UUAGAGGGAU--AGA------ -----------------------------UUUA--------------------------- -U--UUUC-AUA--UC-U-GGCCGUACCGAUAACCGCAUCAGGUCUCCA-AGG-UUAACA -G-CCUCUGG-UC-AA-UAGA-UUAAUGUA-GAUAAGGGAAGUCGGCAAAA-UAGAUCCG UAACUUCGGGGAAAAGGAUUGGCUC-UA--A-GG-GUUGAGU-AU-AUAGAC-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------CCAUCAAUU-A--U-U----A-U-A-UU---A--A--G-C-U--GU---U- -U--U-U---U-UG----A--CU--UU-A-U-A-AU------------------------ ------------------------------------------------------------ -----------------------------------------------------------C UU-U------------------------------------AU--U-GG---A----U-U- A-UU--UU-GAAU-UU-A------A-A---A-C--G-G-------CAA-A------AUA- -U-AUAAU---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UA------------------------------ ---------------AU-G----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------G--AUU--CA---------------U-CUA---UAU-A-CAU--- UGAA--CAA-C-UAAC-UUAGAACUGGAGCGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAUAGCAUUGCGA-UGGCCA-GAA---A-A------------UGGUGU-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-ACAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAACCCACAG--CCAAGGGAA CGGGCUUGGAAUAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC UUUGUGAAAUGGCUUAGAAGGUGUAGCAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UACG----------------G--CG- AUCU-UGAAAUA-CCACUACUUUUAAUGUCAUUUUACUUA-UUC-C--GUU--------- ----------------------------------AU----------------AUU----- ---------G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AGCC- ------------------------------------------------------------ --------------------------------------------UCA------------- --------------------------------------UU-------------------- ------------------G--CU-------------------GAU-CU-UCGCG-GAAGA -CAU-AGUCAGAUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AAAGGUAAC-GCAGG UGUCCUAAGGUAAGCUCAAUGAGAACAGAAAUCUCAUGUA-GACCAA-AAGGGGAAAA-G CUUACUUGAUUU-UGAUUUUC-A---GUACGAAUACAAACUGUGAAAGCAUGGCUU-UUC AGUACGAAUA-CAAACUGUGAAAGCAUGGCCUAUCGAUCCUUUA-GAUCUGUGAAAAU-- ----------------------------UACAGCUAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUUCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGGGAUGCAGAAGUCCCAAAGUGUCGGAUUGUUCACCCG CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-AUA-------------------------------------------------- -----UGAUAUU-GCGACAGUAA--UCUAACUUAGUACGAGAGGAACAGUUAGGUCACAU AAU-UGGUUAAUACAGC-UAGUU-GAAA-AGCU-AG--UGCUGUGAAGCUA-CCAUGUGU --U-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------AUA-CUG--AAU-- --AUGCAAU---------------------------GU--UAUUCAC----CA-A--U-- U--UUA-A-UGUU----------------------------------------------- ------------------------------------------------------------ ------------AC--AUGUAAACAAAUA----------------------G--G----- -U------------------------UAUUU------------------------U-U-- U--AAC-CC--UACUUCAUA-CUAAGGUAUC-----------------AA-CGCUUAU-U --ACG--------------UUAUA------------------------------------ --CUAA------------------------------------------------------ ------------------AAAAAUAAUUUCA----------------------------- AAUAUUAAA-AUUG-----AU-ACAUC---CUCU--G-UAUACGACUU-UG---AUGCAU CCAGGUAUUGUAAG-UACGAGAGUAA--G-C--------------UUUGU--CUUAC--G -AUCUAC--U--GAGAUU-CA-UCCUG---UG-U-UCU--AAAGUG-UG--U-AUUUUUG GA------ >Cyanidioschyzon_merolae -----------AAUCUACAGCUCCUGGC-GGUGGAUA-UCU-AGGCU-CUC-G--CAG-C GAUGAAGAACGCAGC-AAAGCGCGAUAGUUG-GUGCGAUUUGCAGGUUU-C-G-U-GAAU CAUCGAGUCUUUGAACGCAAGU-GGCGCUCGCGGGUUCG--------------------- -----------CUCGCG------------------AGCA--------------------- -------------------------------------------------------UGC-C UGUUUGAGUGUCAGCAACCUUGCUCCUCCGC--------------------GGCGGGCGC GGGUGCGUGACCUCAAAUCA-GGCAAGAUG-ACCCGCUGAAUUUAAGCAUAUCACUAAGC --GGAGGAGAAGAAAAUAACCAUGAUUCCCCUA-GU-AGC-GGCGAGCGAAGCGGGAGG- AGCUCACGCUGGGAACCGGG-CGCC-------UCGCGCGUCCGGGUUGUAGCCUUG---- ----------------------------CGAGACGGC----------------------- ------------G------CCA--GUGCCG----CGCCGGA------CCC-AAGUC-GCU UG-GA-------AGAGC------G-CAUCCGGAGAGGGUGAAAGUCCCGUCGGUGGUCC- -GGAGGGCG---------GUGCGC-AGCGGGCCGCGCUCUACGAGUCGGGUUGUUU---G GGAAUGCAGCCCCAAG-UGGGUGGUAAACUUCACCUAAGGCUAAAUACCGG-CG-AGAGA CCGAUAGC-GAA-CAAGUACCGUGAGGGAAAGAUGAAA-AGCAC-UUUGAAAAGAG-GGU GAAAA-GCGCUUGAAACCGCCAGGAGG---G-AAGCG-AAGGGAGUCGAUGCCGC----- -------------------------------GCC--GGG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GCCGCGCG-----CCGCAGCUGCAAGACGCCAUCC-------GGC- ----GCCGCCAG-GCAACUGGCAGC--------AGCGGG-------CGCGCGCCCGGCCU GCGGGUCCGCG--UC--------------------------------------------- --GG-CUCGCG-----------------G--CGCA--GGAGCGGCUGC------UGG--- --CAAGGUAGCCGGCC-CG---GUCG-----CC--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GGGUCUG--- GCGC------------------------------------UAUAGGC------------C AGCGGAGCCG-GCUGUG-CGGCGGGC---------------------------------- CGGGG-CG-ACGCCUCGG---------CAACGGG--GCGCG----------------ACG -CGGG-------------------------C----G------------------------ --------------------------------------------------------CCAU G------G---------------------------------------------------- ------------------------------------------------------------ ----------------------------CUCUCUCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-C----CGCGCAAGCGA---GUAUUC-GGG--C----------G-GCAA--- --------CCCC-G-A-G-UGCGCAACGAAA-GUGGAG--------GGCGC--------- -------GCCCA--------------G-CGCG-CC-CGA------------------GCU GGGAUCGG--C-G-----------------------------GCGGA------------- --------------------G----C-GC--C--G---CCGUGCACCAGC----GGCCGG CC-A-U----G---AAC----------------------UUGC----------------- -AGU--GAACG-GCCCGCGCG-G-GAGCCUGCGCGGUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGUAGGGCGAAGCCAGA-GGAAACUUCUGGUGGAGGCUCGU--AGCGAUUCU -GACGUGCAAAUCGAUCGUCGAACUUGGGUAUAGGGGCGAAAGACUCAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCCGGAGC-A--------------- -------------------------------GG------------------CG---G--- ---UCC-------------------AGUUUUACCGGGUAAAGCGAAUGACUCGAGGCC-U CGG-G-GGA-G--CGC--AUCCCU-CGACCUAGUCUCAAACUCUAAAUCGGUA-AG--G- A---GCG-CGCGCU---GC-UUUGGU-------------------GAGCGC-G----C-- -G-C-G---------------------------------------------------GAC -AAU---GG-A--CU--G-CUCCG-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGC--UCCGAAAGCGG--CGUUAAG--GUGCC--GAGUGG--C A-C-GC-U-CAU--GCAGA-CCCC--ACA-AAAGGUGUUGAUGCAUUUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGCAC-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUGCCUCAGCCCUGAAAAUG-GAUGGCGCUC-C-AGCGU---GCA--------ACC--G ACA-CGCCGCC--ACC---G--G----CG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GAGCGGU-U-------------------------- -------------------------------GCGC-C-G-G-UG-U--GUAGGA----GG ---G-CGUG-GGGC-CC-------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CCGA AGCGCCG--G-GCGC-GA-GCC--UGCG-U-GGA-ACGGGC-C--CCAGUGCGGAUCU-U GGUGG-GAGUA-GCA-A--AU-AUUCAA-G------------------UGCGAUC----- ----------CUUGAA-GGCC-GAAGGGGAG-AAGGGUUCCA-UGUGAACCGCGAUGGGA CAUGGG------------UGAGUCGG-UC-C-UAA----GGGGCA--GGCCAA--CGCC- ---------------------------G-A-U-GCGA-----GUG-GCG-C--------- ---------------------------GUGA----------------------------- --------------GC-GC-C-G-C------AC-CC---GA-AA-GGGA-AUC-GGG--U UAA----CAUU-CCC----GAACC-G-GGCG--ACGG-A-G------------------- -----------------------------------------------------------G UA---------------------------------------------------------- --------------C-G--CGGCGACGC-C----C-AGGAGC-CUGG-G-GAC-GCCG-G CGCG----AGUCC-CG-GC-G-AGCG------UUGUCUG-------UGC-UUG---UU-- -G------ACU------GC-C------U------G--------A---C-----G--CCCU G-G------A---AG-C--A--G-----C--UGA-C-CUG-GAGAU-AG--GG----C-- -C-GA--CUGG-C--A--G-G--C-AG-A-GCC-CUGCA--------------------- ---------AG-UG-----------------------------C--GC-GGG--GU---C CG-GUGCGCU----CG-C--G-A-CGGCCCGUGAAA-A-CCCAGGGGAC--GGAUUUC-- ------------------------------------------------------------ -C--UCUC-GUG--CC-C-GGCCGUACCCAUAACCGCAUCCGGUCUCCA-AGG-UGAGCA -G-CCUCUGG-CC-CA-UAGA-ACAAUGUA-GAUAAGGGAAGUCGGCAAAA-UGGAUCCG UAACCUCGGG-AAAAGGAUUGGCUC-UA--A-GG-GUUGGGC--C-GG-GGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------CGCCCGG---C--G-C----G-C-G-GC---C--G--C-C-U--G--CGG- -C--G-C---C-UGC-G-C--CU--AG-C-G-A--------------------------- ------------------------------------------------------------ -----------------------------------------------------------G CG-A----------------------------------UCG--CG-GG---GC-G-C-G- G-GC-GCU-GCGG--G-U------G-----U-G--C-G------CG-C-G------GC-- -G-GGAGCG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGCGCG---A----------------------- ----------------GCC----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------C--G-C--G----U----------------G-CCG---CCG-G-CGG--- CGAA--CAA-C-CGAC-UUAGAACUGGUACGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAUAGCAUUGCGA-UGGUCG--GA---A-A------------CGAUGC-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUCAACG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCCGAC UCUGUGAAACGAGUUAGGAGGUGUAGCAU-AAGUGGGAG-CC-G--C------------- ------------------------------------------------------------ -----------------------------------UCGC--------------GG--CG- AUCC-UGAAAUA-CCACUACUCCUAGUCUUGUUUUACUUA-CUC-C--AUGA--GG--CA GA-----------------------G-A-CG-GGCG----------------AAA----- ---------GC-C-C--U-G--C------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCAAAAG- ------------------------------------------------------------ --------------------------------------------CCAC------------ ----G---CC---G--G---C-----------------GCCG------------------ ------C-------C--GG--CC--------------------AU-CU-GCGUG-GAGGA -CAA-GGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGCUA-AACGAUAAC-GCAGA UGUCCUAAGGUGAGCUCAAUGAGAACGGAAAUCUCAUGUG-GAACAA-AAGGGUAAAA-G CUCACUUGAUUU-GGAUUUUC-A---GUACGAAUACAAACUGUGAAAGCAUGGCCU-AUC G-AUCCUUUG-------------------------G--AC-----G-UUCG-AAG-UU-- ----------------------------UGAAGCCAGAGGUGU-CAG-AAAAAGUUACCA CAGGGAAUAACUGGCUUGUGGCAGCCAAGCGUUCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGUGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG--CGUC------------------------------------------------- ------GUUGUC-GCGAUAGUAA--UCCAGCUUAGUACGAGAGGAACCGCUGGUUCAGAU ACU-UGGC-UCAGCACU-UGGCU-GAAC-AGCC-AG--UGGUGCGACGCUA-CCAUCUGU --C-GGAUUAUGGCUGAACGCCUC--U-AAGCCAGAAUCC------GUG-CUA--GA--- -A--GCGAC---------------------------GA--UACCUUU----CU-C--G-- C--CCG-G-ACCG----------------------------------------------- ------------------------------------------------------------ ------------CU--UCGAGCCGGUCUA----------------------G--G--G-- -C--G--------G------------CGCGC------------------------G-CCG CC-GCC-CC--AGGGCCAUAGAGCACGGCGU------------------C-GGGU--GCU -GCGC-GUC----------GAAGC-------------------GC-----G--CG--CGG C-GCCC------------------------------------------------------ ---------CGC--CGCAGAGCGCCAUUGCA----------------------------- CGGCACGGG-CGGG-----AC-AAAUC---GCCU--G-UAGACGACUU-GA-AUG-GGAA CGCAGGGAUGUACG-CAUCUGAGUAG--C-C--------------UUGCU--GCUAC--G -AAAUGC--U--GAGUCU-UA-GCUGC---UG-U-UCCG-GGAUUU-GU---GAGCAGC- -------- >Danio_rerio -----------------CAACUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAACUA-AUGUGAAUUGCAGGACA-CA--U-CGAU CAUCGACACUUCGAACGCACUU-UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCCA--------------------- -------------------------------------------------------CGC-C UGUCUGAGCGUCGCUUUC------------------------------------------ ----UUACGACCUCAGAUCA-GACGAGACA-ACCCGCUGAAUUUAAGCAUAUUACUAAGC --GGAGGAAAAGAAACUAACCAGGAUUCCCUCA-GU-AGC-GGCGAGCGAAGAGGGAAG- AGCCCAGCGCCGAAUCCCCGC--CCCGUG-CCAGGGGCGAGGGAAAUGUGGCGUAC---- ----------------------------GGAAGAUCG----------------------- ------------CU-CUCUCUC--GGCGCG--GGCCGGGGG------UCU-AAGUCCUUC UG-A--------UGGAGGCU---U-AGCCCGUGGACGGUGUGAGGCCGGUAACGGCCCC- -CG-CCCCG---------C----C-GGGGUACGGUCUUCCCGGAGUCGGGUUGUUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGU-CGA-CAAGUACCGUGAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAACAGGGCGUGAAACCGUUGAGAGG---U-AAACG-GGUGGGGUCCGCACGGUCCGCC CGG----AGGAUUCAAC-CCGGCGGGGCUG-GUC--GGCCCGU-CCGGUG-----CGCUC GGAUCCCCC--------C------------------------------------------ -------------------------------CCUCUCGG--------------------- ---------------------------------------------------------GGG AGGGGGACCGGC-GCCCGGACGGAGCUCGGCCGCCGCCGGGCGCACUUCCUCCGUCGGCG GUGCGCCGCGAC-CGGCUCCGGUUCGGCUUGGAAGGGUU-------CGGGGGC---GAAG GUGGCUCGCGGCUCCG-------------------------------------------- --GC-CUCGAGCUUUACAGCGCCCCCCCGCCCCGACUUCGCCGCUUGCUACCCGGGGCCG CGGGCAGUGUCCUCCGCGCC--UUCU-----CUC-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CGGCCCC--- UCUC------------------------------------UCGGGGG-------GGGCUC GGAGGGACGG-G------------------------------------------------ ---------GCCCCUCGC---------UCCCGGCGCGUGCG----------------UCG -ACCGG------------------------------------------------------ ----------------------------------------------------------AA C------GGACUGUCCUCAGUCCGUUUCCGA-------CCGCGCCGUGCCGCCCAGGGCG GG----------GACA-GGCC---------------CAC--GUCC--------AA-AAGG GCGCCCGAGGUCCGCGGUGAUGCCGGCCACCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CGCGCGCGCGA---GUCAGA-GGGUGC----------CCUCGA--- --------GCCC-C-C-ACGGCGCAAUGAAG-GUGAAG--------GCCGG-C------- -------GCGC-----------------GCCG-GC-CCA------------------GGU GGGAUCCCCCCGC-C---C--C----------G---------GCG--------------- -------------------------------G--G---GGGCGCACCACC----GGCCCG UC-U-C----G---UCC---------------------GCUCU----------------- --GU--CGGGGAGGUGGAGC-UA-GAGCGCGUGCGAUGG-UACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGCCCGC--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- -------------------------------CG------------------CCA------ ---CGC-------------------AGUUUUAUCCGGUAAAGCGAAUGACUAGAGGCC-U UGG-G-GCC-G--AAA--CGACCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCUU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--GACGCCC-AGU-GGG-CCU--UU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUC---G--A---CGG-C----------------------------- ------------------------------------------------------------ ----------------------------------------------------------AG AAGGAGCCCCCCCCUCCGGGGGGGGAAAGGGUAA-------------------------- -------------------------------GCCU-C-G-A-CG-A--GUAGGA----GG ---GCCGCC-GCGG-UG-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CGGA AGCCUAG--G-GCGU-GG-GCC--CGGG-U-GGA-GCCGCC-G--CGGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAGC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UAA----GGGAUG--GGCGAA--CGCC- ---------------------------G-U-U--CGGAA---GGGAGG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUC-----G-CCC-C--CGG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAACC-C-GGA---GUGGCG-GAG--A----C--G----GG CG--------------------------------------------------------CC GCGA-----------------------------------------------------GGC ------GCC-CAG-U-G--CGGUGACGC-A----A-ACGAAC-CCGG-A-GA-AGCCG-G CGGG----AGCCC-CG-GG-A-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCCU G-G------A---AU-G--G--G-----U--UCG-C-CCC-GAGAG-AG--GG----G-- -C-CC--GCGC-C--C--U-G--G-AA-A-GCG-CCGCG--------------------- ---------GU-UC-----------------------------C-GGC-GGC--GU---C CG-GUGAGCU----CU-C--G-U-CGGCCCUUGAAA-A-UCCGGGGGAGAAGGUGUAA-- ------------------------------------------------------------ -G--UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CGUGU-UGGA-ACAAGGCA-GAUAAGGGAAGUCGGCAAGU-CAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGC-CG-GU-CGG-------- ------------------------------------------------------------ -------------------------------------GCUGAGGUGCGAAGCGGGGCUGG GCCCGCGCCGCGGCUGGGGGA---------------------GCGGCCGCCCCGCGGCGC CCCCUCUCGUUCCCGUCU-C-CG-GAGCAC-GUC-GU--GC--G--G-C-CC-CUACCC- -C--CCGUCGC-CCG-C-C--UC-UUG-C-U-C-GCG-UCCG-UCCG-GUCGCC--CCCG CC---------------------------------------------------------- -----------------------------------------------------------U UC-G--GGUGGGGG-A--GGCCG-G--G-C--G-GCUCGUGG-GCUCG---GGGU-G-G- G-UGUUGC-GGGU-AG-GGGGGGUG-U---CCG--CUG------CGGCGC------GCC- -GAGGGUCG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGGCCUGCGGGGGGGGAUGCGCUG CGGUGUGCGGCGGCGACUCUGGACGUGCGCCGGGCCCUUCUCGCGGAUCUCCCCAGCUAC GGCCCGCGUCGGGACCUCCGUCUGGCGUCUUCU---C--C-------------------- --------------UCUCGG---------------------------------------- ------------------------------------------------------------ ----------------------------------------------GGGGAGGGCAC--- -GGG--C-G-G--GCG--GCCUCCC---CGGCGCGGCGCCU-CGG---CCG-G-CGC--- CUAG--CAG-C-UGGC-UUAGAACUGGUGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCC-GUG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UGC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC ACUGUGAAGAGACAUGAGGGGUGUAGAAU-AAGUGGGAG-GC-C--C------------- ------------------------------------------------------------ --------------------UGGGGCCCUCGGGCCCAGC----------GGGCGC--CG- CCGG-UGAAAUA-CCACUACUCUUAUCGUUUCCUCACUUA-CCC-G--GUUG--GGCAGG GA-----------------------G-G-CG-AGCCC------------CCGGCGG---- ---------GC-U-C--C-U-GC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCUGGCG- ------------------------------------------------------------ --------------------------------------------UCAAG---------CG CCUCG--GGG---CCCA---U-----------------CGCG------------------ ---G--U-C-----CCGGG--CGC------------------GAC-CU-GCCCC-GGGGA -CAG-UGGCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AACGGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGCG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUAUGAGUACGGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--GC-----U-UUUU-GGG-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGU-C-CGU------------------------------------------------ ------GUUGUU-GCAAUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGCGUGUGCU-UGGCU-GAGG-AGCC-AC--UGGUGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------CGC-CUAAACG--- UA--ACGAU---------------------------AC--CGCAG------CG-C--C-- G--CGG-G-GCUU----------------------------------------------- ------------------------------------------------------------ ------------CG-AUUGGCCUGGGAUA---------------------GC--C--GG- -C--C---------------------GGGGU------------------------U-C-- G--CCC-UC--GGUC-GGUGCGGAGAGCCAG------------------C-CGUG--A-C --GGGACCG----------GGGCGC--------------------G---GC--CGAACG- A-GCGCCGC--------------------------------------------------- ---------CCC-UCUUCCGGUACGCACCGCAUGUUU----------------------- GUGGGGAAC-CCGG---UGCU-AAAUG---ACUC--G-UAGACGACCU-GA-UUCUGGGU CAGGGUUUCGUGCG-UGGCAGAGCAG--C-U-CCAUCGCUGCG-AUCCAU--UGAAA-GU CAGCCCU--CGAUCCAAGUUU-UGU------CGGCCUGA-GGUGCA-AG---GGGCCUUU -AGGU--- >Dictyostelium_discoideum ---------------------CAUAAAC-GGUGAAUA-CCU-CGACU-CCU-A--AAU-C GAUGAAGACCGUAGC-AAACUGCGAUAAUUC-ACUUGAAUUGCAGCCUA-CU--G-GGAU AGUUGAAAUGUUGAACGCACAU-GAUGACAUCGGUCCUU---------------U----C G-----G---AUUAGGU------------------GUUA--------------------- -------------------------------------------------------UAC-U UGGGUGAGAGUGGUC--------------------------------------------- --CUGAUUCCGCCUCACCUU-UGUAAGAUU-ACCCGCUGAACUUAAGCAUAUCAGUAAGC --GGAGGAAAAGAAACUAACUAGGAUUCCGUCA-GU-AAC-GGCGAGUGAAGACGGAAUA GCCCAAGGUUCAAACCUGGAUCUCUUCGAGGUUAGGUGAUGUGACCUAUGGACUGA---- ----------------------------UGGAGCCCG----------------------- ------------C-------UG---UUGUG--ACU------------GCU-AAUUCCGUU UG-GA-------AUUUC------G-AGUC-GUAGAAGGUGAUAACCCUGUUCGCAGUAUC -ACAAC-AG--UUGGACUUU------GCCA--UUAGCUCCACGAGUAGGAAUGUCU---G AAAUUGCAUUCUGAA--UGGGUGAUAAGAUUCAUCCAAGGCUAAAUAUAUGUUA-GGAGA UCGAUAGC-AUA-CAAGUACCGUGAGGGAAAGGUGAAA-AGAAC-UUUGAAAAAAG-GUU UAAAA-GUAUUUGACACCGUUUAUGUG---G-AAGCG-UUUACUUGGACCCCGAUUAAUG ACGUC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUUUAGCUCUA-AUUCUUAGGUGGCCAAAGU AGAGUGUUACGUG---------C---UGAUCAAAAGG----------------UAACGGA CAUUUGAUUCAUU-GGUU---AUCGACGAGGAAGGUACUCU-----AAAUCGGCCAGUU- ACUA--------------A-CGGGUGAGA-UC---------UGAUGUUU-AUAAAAUG-- -GGGGAUGAG-GCU-UAUCGGCUU--------GCUGGUGGC-----UCGCUCUCAAUAAU GGAUAUUG--GGUUUCAUC--------------------------------------AAG -AGUGCAAAAUGGUGGCAAUUCACUAUUAGUGGUUAUUAAUUUUGUUUGCGUGGCUUGGC CUUGUCUACAGGUUAUC--UUC---GGAUGGCU-----UG----UAGCUUUGUUG-AACG CGUGGGCUUAAUGUUGUGAUUCUA-------------GUAGCGUUACCAUAUCGU----- ------------------------------------UAGAGUGGG--------------- ----------UU----------------CAAUAAAUGUCCCGUCUUGAAACACGGAUCAA GGAGGCCG-U----UUUGUGUGCGA---GUGUAA-GAG--U----------AAUUAA--- --------AACU-C-U-GACGCGUAUUGAAA-GAAAGAA--------------------- ---------------------------------------------------------UAC UCCAAAAGAUCG--U---A--A----------C---------UACG-------------- -----------------G--U----U--A--C--C---UUCUGUAAGGAG---UGCCCGA AUCA-UGA--G-AACUC----------------------UGUU----------------- --UC--GAAAGGAUUUGCGG-UU-GAGCACCUAGAAUGG-GACCCGAAAGGUU-GUGAAC UAUGCCUGAGGAAGGCGAAGUCAGG-GGAAACU-CUGAUGGAGGCUUGU--CGCAAUGCU -GACGUGCAAAUCGCUUGUCUAACUUGGGUAUAGGGGCGAAAGACUAAUCGAACAACC-U AGUAGCUGGUUCCUUCCGAAGUUUCCCUCAGGAUAGCUGGAGC-A--------------- -------------------------------GU------------------AUU------ ---CU--------------------AGUUCCAUCUUGUAAAGACAAUGAUUAGCAGUU-U CGG-G-GGC-G--UAA--UGCUCU-CAGCUGAUUCUCAAACUCUGAACGGGUG-GG-UAU C---AUU-UUAAUU--CAC-UUAAUU-GGAUUUUAAAAUUAAAUUGCAC-AUG----U-- -G-C-A--------------------------------------------------AUGA -AAAA--UA-G--GA--G-CUCUU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-UGGGU----UGA--ACCAAAUAUUG--GGAUAAG--ACGUC--UAAC-A--U U-C-AC-U-AA----UAGA-UACC--ACA-AAAGGUGUUAGUUCAUUAAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGUAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----A AAUGGACUAGCCCUGAAAAUG-GAUGACGCUAGC-AGUGG---AUG--------GUC--G AUG-CCCAAUC--GUU---A--A---AAG-A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AGUGAUAA-------------------------- ------------------------------UACUU-U-UAA-CG-U--GUAGGA----AG ---G-CGUG-AAGG-UA-------------------AC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGCUU-G--A-AUGU-GA-AUU--CGAG-U-GGA-GUUGUC-U--UUAGUGCAGAUCU-U GAUGG-UAGUA-GCA-A--AU-AUUCAA-A----------------AGAAUUUAC----- ----------UUUGAA-GGCC-GAAGUGGGG-AAGGGUUCCA-UAACAAUGGAAUUCACU UAUGGG------------UGAGUCGA-UC-C-UAA----GGUUUG--GGUUAA--CUCU- ---CUCUAAUAAGGUUACUAGGUCAUUG-GAU--CGA-----AAG-UGAAG--------- ---------------------------GUGGC---------------------------- ------UUUAAC--ACUA--G-UGACUUUAUAGGCC---GA-AA-GGGA-AGC-GGG--U UAA----AAUU-CCU----GCACC-AUCGA---AUGG-G-A------------------- -----------------------------------------------------------U AU---------------------------------------------------------- --------------U-A--GGGUAACCG-A----U-CGUAAU-CCGG---GAC-AUCA-A UUGG----CGGUC-GA-GG-A-AGAG------UUAUCUU-------UUC-UUG---UU-- -A------ACA----UUGU-C------U------U--------G---G----GG--UCCU CCG------A---AU-C--A--G-----G--UCA-A-CUG-GAGACGAG--GA----U-- -U-CA--UCGCACAAU--G-G--A-AG-A-GCA-CAGUC--------------------- ---------CU-UU-----------------------------G-GAU-UGG--GUC--U CG-CAUC-CG----CU-A--A-A-UGGUCCUUGAAA-A--CCGGAUUAU--GGUAUUU-- ------------------------------------------------------------ -A--AUCCUAUU-UGG-U-GUUCGUACCAAUAACCACAUCAGGUCUCCA-AGG-UGAAUA -G-CCUCUGG-UC-AAAUGUA-UUAAUGUA-GAUAAGGGAAGUCGGCAAAA-CCGAUCUG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-AG-GCUGG---UG-GA-GUG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GACAUAUU--G--GAG----U-U-U-GC---U--A--U-U-U--GU---U- -U--UUU---A-CUU-U-U--AG---G-A-U-G-G------------------------- ------------------------------------------------------------ -----------------------------------------------------------G CA-A----------------------------------CUGU-UU-UG---A--A-G-G- U-UU-AAG-AUGG--G-U------G-G---UAA--U-U------CUUUCC------AAU- -G-UGAGG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCUUGC--------------------------- ----------------UCGU---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------U--C-U--GCU--U----------------U---A---CG-----AU--- U-AA--CAG-C-UAAU-UUAGAACUGUGACGAUCACCGGGAAUCCAA-----CUGUUUAA UUAAAACAAAGCAUUGCGA-UAAGCU--UA---A-A------------AGCUUU-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAG A---------------UUCAA-CCUAGCACGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUCAAUG AG-A--UUCCC--ACUGUCCCUA-AC-UAC-UAUACAGCGAAACCACUG--CAAGGGGAA CGGGCCUUGCAAAAACAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGAU AUUGCAUAGUGACCUAAAAGGUGUAGAAU-AGGUGGGAG-G------------------- ------------------------------------------------------------ ----------------------------------GGCAAC--------------C--CG- ACGG-UGAAAUA-CCACCCCUUUUGGCGUUACUUUGCUAACUUG-G-AAUAACAGUACCU CA-------UAAUUCAUUUUAUGAUG-G-UUUUGGU---------------GAAUA---- AGCGGAUCAAC-CACGGG-U-GA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAUCUGUGC- ------------------------------------------------------------ --------------------------------------------AAAUU----------- ----G--GGC-A-ACUG---A-----------------UUUGU------------AUAGC AAAGUAG--UCCCUC-UGGUCCCG-----------------UA-UUAUGUCGAC-CAAGA ACAG-UUUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUUUGUUA-AAAGAUAAC-GCAAG UGUCCAAAGGCAGGCUCAGUGAGAACAGAAAUCUCACGUA-GAGUAA-AAGGGCAAAA-G CCUGCUUGAUUC-UGAUUUUC-A---GUACUAAUCGGAACUGGGAAACCAGGGCCU-AUC G-AUCCUUUA--------------------------------------UG--UG-----C -UUA--AAU-CU-----------------UAAGCCUAGAGGUGUCAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGCUCAUAGCGACGCUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCUUAUCAUUGUGAAGCAGAAUUCACAAAGUGUUGGAUUGUUCACCCA CUAACAAGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --UUG--U-CAA------------------------------------------------ ----UUGUUUGC-GUAAUAGUAG--CAUGAUUUAGUACGAGAGGAACUGUCAUGCCGGAU CAC-UGGUCUG-UAGGU-UUAUUUGACAAAAUA-GU--GACCUGCCGCUAC-C--AUC-C GUU-GGAUAAUGGCUGAACGCCUC--U-AAGUCAGAAUCC------AUU-CUAGAAA--- ---CGCAAA---------------------------CC--AAAUG-------CUUUAGAG UGUGAAU----------------------------------------------------- ------------------------------------------------------------ ------------------------GUUG--UAGG-UAACAUUA----------------- ----GG--U--U---G--U--------U-----------GGUGG---------------- --------G-GGAC--C-ACUUU--CAAC-UUUAAACCAUAUGAU--------------- -UAA-UCGC--U-G--UUACACU----------GCAGU--------------------UU ----C--CUUCCGGU-UAUUG--------------------------------------- -----------------------UGG--UGGGUGGCUAAAUU-----------CUAAUUU AUAUCCUCGUUCCGCUCAA--CUCUUC---GAUU--G-UAGACGA-CU-AU-CAAAUGAA CUAGGUGCUGUAAG-CUU---------------------------CCGAG---------- -UAGCGU--U--CAGUU-----ACGA----G-GGGUUGAGGCUUUU-CCAUUAGUUCUUU -------- >Drosophila_melanogaster ------------------AACUCUAAGC-GGUGGAUC-ACU-CGGCU-CAU-G--GGU-C GAUGAAGAACGCAGC-AAACUGUGCGUCAUC-GUGUGAACUGCAGGACA-CA--U--GAA CAUCGACAUUUUGAACGCAUAU-CGCAGUCCAUGC-UG----------------U----- -----------GCUUGG------------------ACUA--------------------- -------------------------------------------------------CAU-A UGGUUGAGGGUUGUAUUAU----------------------------------------- ----AUACAACCUCAACUCA-UAUGGGACU-ACCCCCUGAAUUUAAGCAUAUUAAUUAGG --GGAGGAAAAGAAACUAACAAGGAUUUUCUUA-GU-AGC-GGCGAGCGAAAAGAAAAC- AGUUCAGCACUAAGUCACUU----UGUCUAUAUGGCAAAUGUGAGAUGCAGUGUA----- ----------------------------UGGAGCGUC----------------------- ------------AAUAUUCU-AGUAUGAGA--AAUUAACGA------UUU-AAGUCCUUC UU-AA-------AUGAGGCC--AUUUACCCAUAGAGGGUGCCAGGCCCGUAUAACGUUAA -UGAUUAC-----------------UAGAUGAUGUUUCCAAAGAGUCGUGUUGCUU---G AUAGUGCAGCACUAA-GUGGGUGGUAAACUCCAUCUAAAACUAAAUAUAA--CCAUGAGA CCGAUAGU-AAA-CAAGUACCGUGAGGGAAAGUUGAAA-AGAAC-UCUGAAUAGAGAGUU AAACA-GUACGUGAAACUGCUUAGAGGU--U-AAGCC-CGAUGAACCUGAAUAUCCGUUA UGGAAAAU---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------UCAUCAUUAAAAUUGUAAUAUUUAAAUAAUAUUAUGAGA AUAGUGUGCAUUUUUUCCAUAUAAGGACAUUGUAAUCUAUUAGCAUAUACCAAAUUUAUC AUAAAAUAUAACUUAUAGUUUAUUCCAAUUAAAUUGCUUGC------------------- ------------------------------------------------------------ ------A-------UUUUA--ACACAGAAUA-------AA----UGU-UAUUAAU----- ------UUGAU------------AAAGUGCUGAUAGAU-UU-----AUAUGAUU------ ACAGUGCGU----UAAUUUUUCGG-AAUUAUAUAAUGGCAUAAUUAUCA--U-U-GAUUU UUGUGUUUAUUAU---------------AUGCACUUGUAUGA---UUAACAAUGCGAAAG AUUC-------------AGGAU-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ACCUUCGGGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CAUAUGUGCAA---GUUAUU-GGGA-UA-----------UAAA--- ---------CCUAA-U---AGCGUAAUUAAC-UUGACU-AAU------------------ -----------------------------AAUGGG----------------------AUU A------GUUUUUUAGCUA-----------------------UUUA-------------- -------UAGCUAAUUAA---------------------------CACAA-UCCCGGGGC GUUCUA-UAUAGUUAUGUAUAAU-GUAU----------AUUUA--UAUUAUUUAUGCCUC UAACUGGAACGUA-C-----CUU-GAGCAUAUAUGCUGU-GACCCGAAAGAUG-GUGAAC UAUACUUGAUCAGGUUGAAGUCAGG-GGAAACC-CUGAUGGAAGACCG---AAACAGUUC UGACGUGCAAAUCGAUUGUCAGAAUUGAGUAUAGGGGCGAAAGACCAAUCGAACCAUC-U AGUAGCUGGUUCCUUCCGAAGUUUCCCUCAGGAUAGCUGGUGCAUUUUAAUAUU------ ---------------------AUAU----------------------------------- -------------------AAAAU-AAUCUUAUCUGGUAAAGCGAAUGAUUAGAGGCC-U UAG-G-GUC---GAAA--CGAUCU-UAACCUAUUCUCAAACUUUAAAUGGGUAAGA--A- CCUUAACUUUCUUGAUAUGAAG-A-UC---A---A-G-G--------------------- ------------------------------------------------------------ -UUAUGAUAUA--AA--U-GUCCC-AGU-GGG-CCA--CUUUUGGU--AAGCAGAAC-UG -GCGCUG-UGGGA----UGA--ACCAAACGUAA--UGUUACG--UGCCC--AAAUUA--A C-A-AC-U-CAU--GCAGA-UACC--AUG-AAAGGCGUUGGUUGCUUAAAACAGCAGGAC GGUGAUCAUGG-AAGUCGAAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAGCAACUAGCCCUUAAAAUG-GAUGGCGCUU-A-AGUUG---UAU--------ACC--U AUA-CAUUACC--GCU---A--A---AGU-A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------GAUGAUUUAUAUUACUUG------UGAUAUAAAUUUUG--------- ------------------------------AAACU-U-U-A-GU-GA-GUAGGA----AG ---G-UACA-AUGGUAU-------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGUGUUU--G-GCGU-AA-GCC--UGCA-U-GGA-GCUGCC-A--UUGGUACAGAUCU-U GGUGGAUAGUA-GCA-A--AU-AAUCGA-A------------------UGAGAGC----- ----------CUUGGA-GGACUGAAGUGGAG-AAGGGUUUCG-UGUGAACAGUGGUUGAU CACGAG------------UUAGUCGG-UC-C-UAA----GUUCAA--GGCGAA--AGCGA -AAAUUUUCAAGUAAAACAUAAUUU--U-G-A---------------------------- ------------------------------------------------------------ ----------------------------------AC---GA-AA-GGGA-AUA-CGG--U UCC----AAUU-CCG----UAACC-U-GUUG--AGUA-U-CCGUUUGUUAUUAAA----- ---------------------------------------------------UAUGGGCCU CGUGCU------------------------------------------------------ ----------------------CAUCCUGGCAACAGGAACGA-CCAUAAAGAA-GCC--G UCGAG---AG--AUAUCGG-A-AGAG------UUUUCUU--U-----UC-UGUU--UU-- -A----U-AGC------CG--------U------A--------C---U--------ACCA UGG------A---AG-UC-UUUC-----G-CAGA-G-AGA-UAUGGUAGAUGG----G-- -C-U---A-GA-A--G--AGC-AU--G-----A-CAU------AU-A------------- -----------C-U--------------------------------GUU-----GU---G UC------GAUAUUUU-CUCC-U-CGGACCUUGAAA-A-UUUAUGGUGG--GGACA-CG- ------------------------------------------------------------ -CAAACUU-CUC-AAC-A-GGCCGUACCAAUAUCCGCAGCUGGUCUCCA-AGG-UGAAGA -G-UCUCUAG-UC-GA-UAGA-AUAAUGUA-GGUAAGGGAAGUCGGCAAAU-UAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UGA-AGAU-UGAGAUA-GUCG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GCC---------------------UUGA---UU-G-G----G -A-A-AC---AAUA-ACAU-G--GUUUAU--G--U-GC--U-CGU-U-C--UG--GGUAA AUA------GAG-UUUC-U-AGCA------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-A--UGUUAGUUACUUGUUCCCCGGAUAGUUUAGUUACGUAGCCAAU-----U-G--- U-G--GAA------C-U-U------U---------------------------------- ------------------------------------------------------------ --------------------------------------------CUUGCUA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAAUUUU--- -UAAGAAUACUAUUUGGGUUAAACCAAUUAGUUCUUAUUAAUUAUAACGAUUAUCAAU-- U-AA--CAA-U-CAAU-UCAGAACUGGCACGGACUUGGGGAAUCCGA-----CUGUCUAA UUAAAACAAAGCAUUGUGA-UGGCCC--UA---G-C------------GGGUGU-UG-AC ACAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-GUAAGCGCGG-G-UCAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCU--ACUGUCCCUA-UC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGAAUAAUUAGCGGGGAAAGAAGA-CCCUUUUGAGC-UUGACUCUAAUCUGGC AGUGUAAGGAGACAUAAGAGGUGUAGAAU-AAGUGGGAG---------AUA-------UU AGA--------------------------------------------------------- ----------------------------------CCUC--GGUUU--GGUAUCGU--CA- A----UGAAAUA-CCACUACUCUUAUUGUUUCCUUACUUA-CUUGA--UUAAAUGGAACG UGUAUCAUUUCCUA--GC--C--AUU-AUAC--GGAUAU--AUUUAUUAUAUCUUAUGGU AU------UGG-G-U--UUU-GAU--GCAAGCUUCUUGAUCAAAGUAUCACGAGUUUGUU AUAUAA-UCGCAAACAAAUUCUUUAAUAAAACGAUG------------------------ ------------------------------------------------------------ -----------------------------------------------------CAUUUA- ------------------------------------------------------------ -UGU----------------A--UUU---U--UGAUUUGAAA-A---------------- -----UUUGGU-AUAACUCC--A--AU-UACUC-----A-GGU--AU------------- -------------------------------------------GAUCC--AAUUCAAGGA -CAU-UGCCAGGUAGGGAGUUUGACUGGGGCGGUACAUCUCUCA-AAUAAUAAC-GGAGG UGUCCCAAGGCCAGCUCAGUGCGGACAGAAACCACACAUA-GAGCAA-AAGGGCAAAU-G CUGACUUGAUCU-CGGUGUUC-A---GUACACACAGGGACAGCAAAAGCUCGGCCU-AUC G-AUCCUUUUG------------------------G---------UUUAA--AG--AGU- ----------------------------UUUUAACAAGAGGUGUCAG--AAAAGUUACCA UAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAAAAUUCACCAAGCGUUGGAUUGUUCACCCA UGCAAG-GGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUA --AUG--A-CA------------------------------------------------- -----AAACGUUGUUGCGACAGCAUUCCUGCGUAGUACGAGAGGAACCCGCAGGUACGGA CCA-AUGGCACAAUACUUGUUCGAGCGAACAGU-GG--UAUGACGCUACGU-C------C GUU-GGAUUAUGCCUGAACGCCUC--U-AAGGUCGUAUCC------GUG-CUGGAC---- --UGCAAUG---------------------------AU--AAAUAAGGGGCAAUUUGCAU UGUAUGG----------------------------------------------------- -------CUUCUAAACCAUUUAAAGUUUAUAAUUUACUUUAUA-----------AACGAC AAUGGAUGUGAUGCCAAUGUAAUUUGUAACAUAGUAAAUUGGGAGGAUCUUCGAUCACCU G-AUGCCGCGCUAGUUACAUAUAAAAGCAUUAUU-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ UAAUACAAUGACAAAGCCU--AGAAUC---AAUU--G-UAAACGACUU-UU-GUAACAGG CAAGGUGUUGUAAG-UGG---UUGAGCAG-CU-------------GCCA---UACU-GCG -AUCCAC--U--GAAGC-----UU--------AUCCUUU---GCUU-G-----AU-GAUU --CGA--- >Eremothecium_gossypii ----------------AAAACUUUCAAC-AACGGAUC-UCU-UGGUU-CUC-G--CAU-C GAUGAAGAACGCAGC-GAAUUGCGAUAAGUA-UUGUGAAUUGCAGAUUU-UCG-U-GAAU CAUCGAAUCUUUGAACGCACAU-UGCGUCCUCUGGUAUU--------------------- -----------CCAGGG------------------GGCA--------------------- -------------------------------------------------------UGC-C UGUUUGAGCGUCAU---------------------------------------------- ----GUUUGACCUCAAAUCA-GGUAGGAUU-ACCCGCUGAACUUAAGCAUAUCAAUAAGC --GGAGGAAAAGAAACCAACCGGGAUUGCCUUA-GU-AAC-GGCGAGUGAAGCGGCAAA- AGCUCAAAUUUGAAAUCUGG-CGCC-------UUCGGCGUCCGAGUUGUAAUUUGA---- ----------------------------AGAAAGUAC----------------------- ------------C------UUG--GUUGCU--A-GUCCCUG------UCU-AUGUU-CCU UG-GA-------ACAGG------A-CGUC-AUAGAGGGUGAGAAUCCCGUCUGGCGGGG- -GU-GC-UA---------GUGCCA-UCUAAGGUUCUUUCGACGAGUCGAGUUGUUU---G GGAAUGCAGCUCUAAG-UGGGUGGUAAAUUCCAUCUAAAGCUAAAUAUUGG-CG-AGAGA CCGAUAGC-GAA-CAAGUACAGUGAUGGAAAGAUGAAA-AGAAC-UUUGAAAAGAG-AGU GAAAAAGUACGUGAAAUUGUUGAAAGG---G-AAGGG-CAUUUGAUCAGACAUGGUGUUU ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------UGCGGCCCUCGCUCCUUGUGGGUG GGGUC-------A-CCGCAG--UUCA-----CU--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GGGCCAG--- CAUCAG---------UU-----------------------UUGGUGGCA-GCAGAAACCC UUAGGAAUGU-GACUUU------------------------------------------- ----------CUCUUCGG---------AG----GAAGUGUU----------------A-U -AGCCUAAGGUUAUAC--------------U----G------------------------ --------------------------------------------------------CCAA CC----GGGACUGAGGACUGC-GGCUUC---------------------GGCCAAGGAUG C----------------------------------------UGGC--------AU-AAUG G---------------------------UUAAAUGCCGCCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CGUCUAUGCGA---GUGUUU-GGG--U-----------GUAAA--- --------ACCC-G-U-A-CGCGUAAUGAAA-GUGAACGUA------------------- ---------------------------------------------------------GGU GAGG-GCC--U-C-----------------------------UUUA-------------- -------------------------------G--A---GGU-GCAUCAUC----GACCGA UC-C-U----G---AUG----------------------UCUU----------------- --CG--GAUGG-AUUUGAGU-AA-GAGCAUAGCUGUUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAAUAGGGUGAAGCCAGA-GGAAACU-CUGGUGGAGGCUCGU--AGCGGUUCU -GACGUGCAAAUCGAUCGUCGAAUUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCUGCCGAAGUUUCCCUCAGGAUAGCAGAAGC-U--------------- --------------------------------------------------CGUA--UC-- -------------------------AGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUA-C CG--G-GGUUG--AAA--UGACCU-UGACCUAUUCUCAAACUUUAAAUAUGUA-AG--A- A---GUC-CUUGUU---GC-UUAAUU-------------------GAAC-G-U----G-- -G-A-C--------------------------------------------------AUAU -GAA---UGAA--GA--G-CUUUU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGAACGUGG--AGUUAAG--GUGCC--AGAAUA--C A-C-GC-U-CAU--C-AGA-CACC--ACA-AAAGGUGUUAGUUCAUCUAGACAGCCGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCGGCC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUC-A-AGCGU---GUU--------ACC--U AUA-CUCCACC--GUC---A--G----GG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AAAUAUGAC-------------------------- -------------------------------GCCC-U-G-A-CG-A--GUAGGC----AG ---G-CGUG-GAGG-UCA------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------ACGA AGCCUAG--G-CUGU-AA-AGC--UGGG-U-CGA-ACGGCC-U--CUAGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GAAGUGGGG-AAAGGUUCCA-CGUCAACAGCAGUUGGA CGUGGG------------UUAGUCGA-UC-C-UAA----GAGAUG--GGGAAG--CUCC- ---------------------------G-U-U--UCAAA---GGC-CUG-A--------- ---------------------------UUU------------------------------ -----------UC-CA-G--G-C-C-----ACCAUC---GA-AA-GGGA-AUC-CGG--U UAA----UAUU-CCG----GAACC-U-GGAU--AUGG-A-UUCUU--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------C-A--CGGCAACGU-A----A-CUGAGU-GUGG-A-GA-CGUCG-G CGUG----AGCCC-UG-GG-A-GGAG------UUAUCUU-------UUC-UUC---UU-- -A------ACA------GC-U------U------A--------U---C-----A--CCCC G-G------A---AU-U--G--G-----U--UUA-U-CCG-GAGAU-GG--GG----U-C -U-U---AUGG-C--U--G-G--A-AG-A-GCC-CAGCA--------------------- ---------UC-UA-----------------------------U--GC-UGG--GU---C CG-GUGCGCU----UA-C--G-A-CGGCCCUUGAAA-A-UCCACAGGAA--GGA------ -----------------------------AUAG--------------------------- -U--UUUC-AUG--CC-A-GGUCGUACUGAUAACCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUAG-UU-GA-UAGA-AUAAUGUA-GAUAAGGGAAGUCGGCAAAA-UAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-AUCGGGU-AG-UG-AGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCCUUGG---U--CAGA---C-G-C-GG---C-----A-A-G--UG-UGC- -U--U-G---U-GGU-C-U--GU--CC-U-C-G-GGG-G--------------------- ------------------------------------------------------------ -----------------------------------------------------------C UU-G------------------------------CU-CCUGG-GG-AC---GG-A-C-U- G-CU-UGC-GUGCUCU--------G-U---C-G--UAG------AC-G-G------CCU- -U-GGUA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GACCA---------------------------- ---------------UCUCU---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------G-G--UCG--U----------------CGCUU---GCU-A-CAA--- UUAA--CGA-U-CAAC-UUAGAACUGGUACGGACAAGGGGAAUCUGA-----CUGUCUAA UUAAAACAUAGCAUUGCGA-UGGUCA--GA---AAG------------UGAUGU-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC AUUGUGAAGAGACAUAGAGGGUGUAGAAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UUCG----------------G--CG- CCAG-UGAAAUA-CCACUACCUUUAUAGUUUCUUUACUUA-UUC-A--AUUA--AG--CG GA-----------------------G-C--U-GGAAU--------------UCAU----- --------UUU-C-C--ACC--UU------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CUAGCAU ------------------------------------------------------------ --------------------------------------------UUAA------------ ----A--GUC---C------------------------UAUAC----------------- ----------------GGG--CU-------------------GAU-CC-GGGUU-GAAGA -CAU-UGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AACGAUAAC-GCAGA UGUCCUAAGGGGGACUCAUGGAGAACAGAAAUCUCCAGUA-GAACAA-AAGGGUAAAA-G UCCCCUUGAUUU-UGAUUUUC-A---GUGUGAAUACAAACCAUGAAAGUGUGGCCU-AUC G-AUCCUUUA-------------------------G--U------UCCUCG-GAG-UU-- ----------------------------UGAGGCUAGAGGUGC-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUC GAUGUCGGCUCUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG--AAU-------------------------------------------------- ------GUUAUC-GCAAUAGUAA--UUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAU AAU-UGGUUUUUGCGGC-UGUCC-GACC-GGGC-AU--UGCCGCGAAGCUA-CCAUCCGC --U-GGAUUAUGGCUGAACGCCUC--U-AAGUCAGAAUCC------AUG-CUA--GA--- --ACGCGAU---------------------------GA--UUC-UUUUU--CU----C-- G--CAC-A-UUA------------------------------------------------ ---------------------------------------UA-GAUGGAUAC--------- ---GAAUAA---GGU-G------------------------------------------- --------------------------CUUUU----------------------------- -----------------------AGCAU-C--GCUGAACCAUAGCAG-GC-CGGC--A-A CUGGU--GUU-CAGAC---GGAAAG---------GUCU--G--GGC----G--CG--UG- C-CGGC------------------------------------------------------ --------------------------------------GGAUUGCAAUGUCA-------- -UACUGCGC-GAGA----GUA-AAUC----AUUU--G-UACACGACUU-AG-AUGUACAA CAGGGUAUUGUAAG-CAGUAGAGUAG--C-C--------------UUGUU---G----UU AC------G-AUCUGC--U--GAGAUU--AAG-C-CUU-C-GU-UGUC-U--GAU-UU-- GU------ >Gallus_gallus -----------------CAACUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-AUGUGAAUUGCAGGACA-CA--U-UGAU CAUCGACACUUCGAACGCACU--UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------CGC-C UGCCUGAGCGUCGCUUUCCCGUUUC----------------------------------- -CGUUCGCGACCUCAGGUCA-GACGUGGCG-ACCCCUUUAAUUUAAGCAUAUUAGUCAGC --GGAGGAAAAGAAACUACCUAGGAUUCCCUCA-GU-AAC-GGCGAGUGAAGAGGGAAG- AGCCCAGCGCCGAAUCCCCGC--CCCGCG-GU-GGGGCGCGGGAGGUGUGGCGUAC---- ----------------------------GGAAGCCCC----------------------- ------------CAUCCCCGGC--GCCGCU--CUCGGGGGG------CCC-AAGUCCUUC UG-A--------UCGAGGCC---C-AGCCCGCGGACGGUGUGAGGCCGGUAGCGGCCCCC -CG-GCGCG---------C----C-GGGCCCGGGGCUUCUCGGAGUCGGGUUGCUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGC-CAA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGUCCGCGCAGUCGGCC CGG----AGGAUUCAAC-CCGGCGGGCCAAGGUC--GGCCGGCGCGGGCG-----CCGUC GGAUCCCCG--------C--------------CUCCGCCUCCCCUCC------------- -------------------GUCCCU---CCCCUUCGCCGGGGCGG----GGCGGG--CCC AG------------------------G-----------------GGGGGCGGGC---GGG CCGGGGACCGCC-GCCCGGCCGGCGUCCGGCCCCCGUCGGGCGCAUUUCCUCCGC-GGCG GUGCGCCGCGAC-CGGCUCCGGGACGGCUGGGAAGGGCU-------GCCGGCG--GGCAG GUGGCCCGGCGCCGCGCGAG---------------------------------------- CGGCCGCCGGGUGUUAUAGCCGCCG--GGCCCGGAUCGU--CGCCGAAUCCCGGGGCCGA GGGAGAGGACCGCCGCCGCGCCCUCCCCCG-GAGGGGGCGGCCCCCCGGAGGGCCCCCCG CGG---------------CCGGACCGGCGUCGGGCCGGCC-GCGCC-----------GCG CGCGCGUCCGCGCCGC-------------------------------CG----------- -----------CC-GUACGCCGC--------------------C---GCUCGCUCUC--- UCUCCG---------UUCC-CCGCCCCGGGUCCGUC----CCGGGGC---GCGGGGGCGG G-GGGGGUCG-GGUGUC-CGGCGCGCG-----GCUG--GGC-----GCGGCGCCGCGCGU GUGGC-GC-GCGCAUCCA---------GCCCGGCGCGGGCGAGGCCG-CGGGGGGCGCCG GGGGGGAACCUUCCCC--C-U-UCUGUUCGG----GCCGCCUCCGUUCCCGCG------- -------GGGGCGGC-CCGUUCGGGGGACGGGCCCGCCGGCCCCCGGCGCCGCUGUCCGA CCGGGGCGGACUGCGCUCAGU-GCGCCCCGA-------CCGCGCGGCGCCGCCGG--GCC GG----------GCUC-GGGC---------------CA------C--------GC-CAGG GCGCCCGGGGUCCGCGGCGACGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-G----CACGCGCGCGA---GUCGGC-GGC--UC---------GCGCGAA-- --------AGCC-C-G-C-GGCGCAAUGAAG-GUGAGG--------GCCGG-C------- -------GCGC-----------------GCCG-GC-UGA------------------GGU GGGAUCCCGGGGC-G---G-CA----------G---------GCCG-------------- -----------------G--A----A--G--G--CCCCGGGCGCACCACC----GGCCCG UC-U-C----G---CCC----------------------GCCUC---------------- --GC--CGGGGAGGUGGAGC-AU-GAGCGCGCGUGCUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCCGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- -------------------------------CG-----------------GGGC--GG-- --C----------------GGUGC-AGUUUUACCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUCAAUGGGUA-AG--A- C---GCC-CGGCUC---GC-UGGCGUG------------------GAGC-C-G----G-- -G-C-C--------------------------------------------------GUGG -AAU----G-C--GA--G-CGCUC-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-GCCC--AGA-AAAGGUGUUGGUUGAUCUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAC-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CAG--------GCC--C AUA-CCCGGCC--GUC---G--C-CGGCGGU----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GCGGAGCCGC------------------------- ----------------------GGGGGCUACGCCG-C-G-A-CG-A--GUAGGA----GG ---GCCGCU-GCGGUGC-------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UGGA AGCCUGG--G-GCGC-GG-GCC--CGGG-U-GGA-GCCGCC-G--CAGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--CU-AUUCAA-A------------------CGAGAGC----- ----------UUUGAA-GGCC-GAAGUGGAG-CAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUUGG-UC-C-UAA----GCGAUA--GGCGAG--CGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUAGCCUCC----------------------------- ---GUU-----G--CCCU--CAG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUCCG-GGGC-GGCGG-A-G----A---CG--G----G- ----------------------------------------------------------CG CCGC-----------------------------------------------------GAG ----GCGCC-CAG-U-G--CGGUAACGC-A----A-GCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------C------G--------G---G----CG--CCCU G-G------A---AC-G--G--G-----U--UCG-C-CCC-GAGAG-AG--GG----G-- -C-CC--GCGC-C--U--U-G--G-AA-A-GCG-UCGCG--------------------- ---------GU-UC-----------------------------C-GGC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCGUGAAA-A-UCCGGGGGAG--AGGGUGU-- ------------------------------------------------------------ -AAAUCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UGGA-CCAAUGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGU-CG-GU-CGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCUGGGGCG-C--GAA---GC-G-G-GG---C--U--G-G-GC-GCGCGC- -C--GCG---G-CUG-G-A--CG-AGG-C-G-CCGCC-CGCC-CCCG-CCCCCCCUUUCC CC---------------------------------------------------------- ----------------------------GCUCCCGCUCGCCGGGGCGCCGGGGGGGGGGG UC-A--GCGGGCGG-CGCGGCGG-C--G-G--C-GACUCUGGACG-CG---CGCC-G-G- G-CCCUUC-CCGU-GGAU------C-GCCCCAG--CUG------CGGCGG------GCG- -C-CGCUCG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CCCCCC---U--C--C--U-UGC-C-------- -------------CCUCCGCCCCCCCGCUCCCGGCGCCCCUCCCGUCGGCCGUCGUCCCG GCCGCCCCCCGUCCCGAGCGCCCUCCCCGCGAGGGCGCGAGGGGCGGCGGCGGCGGCCGC GGGCGCGGCGGCGGCGGGGGGGGGCCCGCCGGCGGCGCCGGGCGGGGCGGUCCCGGG--- -CGG--G-G-G--G-G--GUCUCCGGGCCGGCGCCCCGCCU-CGG---CCG-G-CGC--- CUAG--CAG-C-CGGC-UUAGAACUGGUGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCG-CG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UCUCCAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC GCUGUGAAGAGACAUGAGAGGUGUAGAAU-AAGUGGGAGGCC-C--C------------- ------------------------------------------------------------ --------------GCGGUCGCGCGACCCGCGCCGCGGC------------CCGG-CCG- CCGG-UGAAAUA-CCACUACUCUGAUCGUUUUUUCACUUA-CCC-G--GUGA--GG--CG GG---------------------GGG-G-CG-AGCCC--------------CGAG----- --------GGG-C-U--CUC-GC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCUGGCG- ------------------------------------------------------------ --------------------------------------------CCAA------------ ----G--CGC---CCGG---C-----------------G-CG------------------ ---C--G-C-----C-GGG--CGC------------------GAC-CC-GCUCC-GGGGA -CAG-CGUCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AAGCGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGCCAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUACGAAUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--AC-----U-UUUU-GGG-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-UGU-------------------------------------------------- ------GUUGUU-GCGCUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AC--UGGAGCGAGGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------CCC-CUAAACG--- UA--GCGAU---------------------------AC--CGCAG------CG-C--C-- G--AGG-CGCCUC----------------------------------------------- ------------------------------------------------------------ ------------GG--UGGGCUCGCGAUA---------------------GC-CG--G-- -C--C---GCCG----C-CC-CC-C-UCGGGC-GGGCGGUCGGUGCGGAGCG--CC-GCU C--GU--GGUCGGG----------ACCGGAG------------------CG----C--GG ACAGAUGUGGCGCCGC------CUC--UCCCCCGCCGCGUACCGCAUGUU-CGUGGGGAA CCCGGUG-----CU-AAAUC---AUUC--G-UAGACGA---CCU-GA-UUCUGGGUCGGG GU---UUCGUA---CGUA--G-CAGAGCA-G-C----UCCCUCGCUGC---GAUCUAU-- UGAGAGUCAGC--C---CUCGA-CACA--AGCUU--U-UGUCGGAGCG-CG-GAGCGCGC GCGCGCGCGCGCGUGGCGGCGCCCCGGCGCGG----------GGCCGGG---UCCGGCGG GCCAGUCGGUCGGCUCCCCG--CGCC----G-CUCCGUUUG-U-UC-CU---GGG--UUC GUUCGU-- >Guillardia_theta -------------UUCCUAGCCCCCAAU-GGUGGAUA-UCU-UGGCU-CCU-G--UAU-C GAUGACGAACGCAGC-AGCGCGCGAUAGGUG-UUGUGAUCCGCAAAACU-AUAUU-UGAU CAUCGAGUCUUCGAACGCAAAC-GGCACGCUCCUCACCA---------------U----C C-----GG-UGGAGUAG------------------CGUG--------------------- -------------------------------------------------------CGC-C CGUCUGAGCAUC------------------------------------------------ GUUUACACGGUCUCAGGUCG-GGCGGGAAU-ACCCGUCGAACUUAAGCAUAUCAAUAGAC --GGAGGAAAAGAAACUAACCAGGAUUCCCUUA-GU-AGC-GGCGAGCGAAUCGGGAUCA GCUCAAGAUUUUAAUCGGCAGUGGUUCCUAUGAUCCACCGCUGAGAUGUAGUCCUA---- ----------------------------AGUGGCGCA----------------------- ------------C------UCG--GGAGAA----GUGGUAU------AUU-AAGUC-UUU UG-GA-------ACAAA------G-CGCC-AUAGAGGGUGAUAGCCCCGUCUGUGUAUA- -CCAAGUCGUCUGAGCCUCUCCCU-GCCGAUGCGCCACUCGUGAGUCGGGUUGCUU---G GGAGUGCAGCCUAAAU-AGGGUGGUAUACUUCAUCCAAAGCUAAAUAUGGA-CA-GGAGA CCGAUAGC-GAA-CAAGUACCGCGAGGGAAAGAUGAAA-AGAAC-UUUGGAAAGAG-AGU GAAAUAGUGCUUGAAACCAUUGGGGGG---A-AAGCG-AAUGGAGCUUCCGUAAUAUCGA AGGAUCUCGAG-------CCAG--CGCUUUGGUU--GGA----UCUGGUG-----U---- -AAUGACUU--------CG-------------AUGAUGCGUCCGUGA------------- -------------------GUUUUU---UCCCUUCUCGUGCGUGC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GUUGA--------ACACA ACGAAAGAAUUCACU-GGCUUCUUCCUCCG-UGUGAG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GCAGAAGCUU UGA--GCUGG-AGUCUUUC--C---------------------------------UUUUU GUUGUUGU-UGGAAUCGA---------CACAGAA--GGGCU----------------CUU -C-GUGAGAGUUUCGA--U-U-UUUGUUUCUC---CACCUCUCCCUUUU----------- ----------------------------------------------------UUUUCCAA A-------------------------------------------------------GGUU GG----------UGGA-GGUC---------------CAAAGAUUG--------GC-AAUG GACGUAGGGG------------------CUUCCUUCGACCCGUCUUGAAACACGGACCAA GGAGUCCG-G----UAUGAGCGCGA---GUGCUC-GGG--A---------AAGUUAC--- --------ACCC-A-U-G-CGCGUAGCGAAA-GCAAUG--------ACUGG-AAUC---- --------UGUU---------CAUCGA-GAAC-GC-UGAUAGACAUUUCCCUCGUUACGA GAGAUCUCUAGAG-U--CU--U----------U---------CAAUCU-UCUCCUUGAAU AGGUAGGUUCUUAAGGUGAGAAAUUUGGCUAAGCUCCAUAUUGCAUCAUC----GUCCAA CC-UAUCU--G---CCC----------------------UUAG----------------- --GGUCGAUUG-GCUUGUGA-UU-GAGCGCUCAUACUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGCAGGAUGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGA--AGGCGUUCU -GACGUGCAAAUCGAUGCUCAGACUUGGGUAUAGGGGCGAAAGACCAAUCGAACCGUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGAGC-U--------------- ---------------------------------------------------GUA--G--- ---C---------------------AGUCUUAUCCGGUAAAGCGAAUGAUUAGAGGAA-U CGGAGAGUC-C--AAA--CUCUUU--GACCUAUUCUCAAACUUUAAACAGGUA-AG--G- A---AGU-UGUGUU---GC-UUAGAU-------------------GAACACAG----C-- -U-G-G--------------------------------------------------AC-G -AUG----G-U--UA--G-CUCUU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGAGAGUGG--UGUUAAG--GCGCC--CAACUA--C G-C-GC-U-CAU--U-AGA-UCCC--AGG-AAAGGUGUAGGUGCGUAUGGACAGCAGGAC GGUGGUCAUGG-AGGUCGACAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AACGCAUCAGCCCUGAAAAUG-GAUGGCGCUC-A-AGCGC---GUG--------GCC--G AUA-CACCACC--GCC---G--G----CG-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ACAGAAUUU------------------------- -------------------------------GCUC-C-G-G-UG-U--GUAGGA----GG ---G-CGUC-GUGC-CU-------------------UU-G-------------------- ------------------------------------------------------------ ------------------------------------------------------CGUCGA AGCCUUU--G-GCGU-GA-GCC--UUGG-UGGAG-CAGGCU----CGAGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AA-AUUCAA-G------------------CGAGAAU----- ----------CUUGAG-GACU-GGAGUGGAG-AAGGUUUCCA-UGCAAACUGUGUUUGAG CAUGGG------------UGAGUCGA-UC-C-UAA----GAGAAU--GGGUAA--UUCC- ---------------------------G-U-U--AGA----GUUG-UGC----------- --------------------------UUCG------------------------------ -----------G--GCAU-GU-U-C-------CAUC---GA-AA-GGGA-AAC-GGG--U UAA----UAUU-CCC----GUACC-A-UGAU--GCGG-A-G------------------- -----------------------------------------------------------U UU---------------------------------------------------------- --------------A-A-GCGGCAACGC-A----A-ACGAUC-UUGG-G-GAC-AUCG-G UGUG----GACAC-UG-GA-G-AGAG------UACUCUU-------UUC-UAA---UU-- -A------ACA------GC-A------C------C--------A---U----CA-ACCAU G-G------A---AU-C--A--G-----G--UUG-U-CUG-GAGA--AG-UGG----U-- -G-GU--GUGU-C--U--G-G--A-AG-A-GCG-GUGC---------------------- ---------CU-UC-----------------------------G-CGC-AUC--GU---C UG-GUUAGUU----CA-U--A-A-CGAUCCUUGAAA-A-CCCGAGGGAG--AAAAUCU-- -----------------------------------------------------------G AC--UCCC-GCG--CA-U-GGUCGUACCCAGAACCGCAUCAGGUCUCCA-AGG-UGAGUA -G-CCUCGAG-UC-GG-UAGA-CGAAGGUA-AGUAAGGGAAGUCGGCAAAA-UGGAUCCG UAACUUCGGG-ACAAGGAUUGGCUC-UA--A-GG-GUUGAGCAUC-GU-CGC-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ACGUUUCCU-G--C-GG---U-U-C-UU---G--A--G-C-GC-GU---G- -U--UCG---A-GAGAC-U--CG-AUG-C-U-C-UCG-AGUC-UCUC-CUCGGC--UCAU ------------------------------------------------------------ -----------------------------------------------------------A CC-A--UGCUUCUU-U--GCAGG-A--G-G--C-UAUAGAG--AG-AU---AUAG-G-A- G-UU-CUC-GGAU--C-U------UCC---UCU--U-C-------C----------ACU- -G-AGAACC--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AUCUGA---A--C-------------------- ----------------UAU----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------G--G-U--GCA--C----------------G--AU---UGU-G-AAU--- AAAA--CAA-C-CAGC-UUAGAACUGGUACGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAUAGCAUUGCGA-UGGCCG-GAA---A-U------------CGGUGU-UG-AC GCAAUGUG-AAUUCUGCCCAGUGCUC-UGAAUGUUAAU-GUGAA-------------GAA A---------------UUCAA-GGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CU-UAC-CAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGAAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGCUUUGACUCUAGUCUGGU UUUGUGGAAUGAGUCGAGAGGUGUAGCAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UUCG----------------G--CA- ACAG-UGAAAUA-CCACUACUCUUGGUCUUUUUCCACUCA-CCC-C--GUUA--GU-CCG GA-----------------------G-G-CG-GCCU-------CGGUUGUUUACCU---- --------AGG-C-U--C-U-CC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------UUUAUUGUU- ------------------------------------------------------------ -------------------------------UGUGUAAUCUGGGAGAAC----------- ----A--UCU---C--C---C----------------UCUCG------------------ ---G--G-A-----A-GUU--UCU----------------CCUAC-CG-GUACG-GAGGA -CAU-AACCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGCUA-AAAGAUAAC-GCAGG UGUCCUAAGAUGAGCUCAGUGAGAACAGCAAUCUCAUGUG-GAGUAG-AAGGGCAAAA-G CUCAUUUGAUUU-GGAUUUUC-A---GUACGAAUACAAACUGUGAAAGCAUGGCCU-AUC G-AUCCUUUA------------------------CG--A------C-UUCG-AAG-UA-- ----------------------------UGAAGCUAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCGAGCGUUCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACAAAGCGUUGGAUUGUUCACCCA CUGACAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG-AC-AG------------------------------------------------- ------GUCGUC-GUGAUAGUAA--UUCAGCUCAGUACGAGAGGAACCGUUGAUUCAGAU AAU-UGGUCUUGGCACU-UGGCU-GAGA-AGCU-AU--CGGUGCGGAGCUA-CCAUCUGU --C-GGAUUAUGGCUGAACGCCUC--U-AAGCCAGAAGCC------UUG-CUA--GA--- -A--ACGAC---------------------------GA-UAGACAAU----CU-C--U-- C--CUG-G-UUUC----------------------------------------------- ------------------------------------------------------------ ----------GAUG--U--GAUAUCCACA---------------------GG--G--C-- --------------------------AUA------------------------------- G--UGU-AA--GAGC-AAUG--GG--GGUAA-----------------AC-CCUU--U-U --GCU--------------CU-UGU--------------------G----C--CG--AA- U-GUAC------------------------------------------------------ ---------CCG--UGUCAAUCAGAGUAACGGUGAGC----------------------- GUGG-GAGUGAGUG-----AU-GACUC---GUU---G-UGUAUAUCUU-ACUUCUUUUCG UUAAGAAUGGAGAG--GACACAUCGU--G-U--------------UUUCA--GUAUA--U -CUCUAC--G--AGGAUA----A-AC----G-GG-AGGG-UACAAAGGGGUUGCUUUUUC CCUUU--- >Homo_sapiens -----------------CGACUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-AUGUGAAUUGCAGGACA-CA--U-UGAU CAUCGACACUUCGAACGCACU--UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------CGC-C UGUCUGAGCGUCGCUU-------------------------------------------- -----CGCGACCUCAGAUCA-GACGUGGCG-ACCCGCUGAAUUUAAGCAUAUUAGUCAGC --GGAGGAGAAGAAACUAACCAGGAUUCCCUCA-GU-AAC-GGCGAGUGAACAGGGAAG- AGCCCAGCGCCGAAUCCCCGC--CCCGCG-GC-GGGGCGCGGGACAUGUGGCGUAC---- ----------------------------GGAAGACCC----------------------- ------------GCUCCCCGGC--GCCGCU--CGUGGGGGG------CCC-AAGUCCUUC UG-A--------UCGAGGCC---C-AGCCCGUGGACGGUGUGAGGCCGGUAGCGGCCC-C -CG-GCGCG---------C----C-GGGCCCGGGUCUUCCCGGAGUCGGGUUGCUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGU-CAA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGUCCGCGCAGUCCGCC CGG----AGGAUUCAAC-CCGGCGGCG---GGUC--CGGCCGUGUCGGCGG---CCCGGC GGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCUCCACCCGCCCUCCCUUCCCCCGCC-- -------------------GCCCCUCCUCCUCCUCCCCGGAGG-G----GGCGGG--CUC CG----------GCGGGUGCGGG---GGUGGGCGGGCGGGGCCGGGGGUGGGGU---CGG CGGGGGACCGUC-CCCCGACCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGC-GGCG GUGCGCCGCGAC-CGGCUCCGGGACGGCUGGGAAGGCCC-------GGCGG----GGAAG GUGGCUCGGGGGGCCCCGUC---------------------------------------- CGUCCGUCCGUCCGUCCUC---------------CUCCUC-CCCCGUCUCC--GCCCC-- ---------CCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGCG-GGUCGGGGCGGCGGCGG CGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAA-ACCCC-----------CCC CGAGUGUUACAGCCCCC---------CCGGCAGCAG-----C-A-CUCG----------- -----------CC-GAAUCCCGGGGCCGAGGGAGCGA-GA--CCCGUCGCCGCGCUC--- UCCCCC---------CUCC-CGGCGCCCACCC--------CCGC------GGGGAAUCCC CCGCGAGGGG-GGUCUCCC-CCGCGGG-----------GGC-----GCGCCGG--CG--- ---------UCUCCUCGU---------GGGGGGGCCGGGCCACCCCU-CCC------ACG -GCGCGACCGCUCUCCCAC-C-CCUCCUCCC------------------CGCG------- -------CC-----C-CCGCCCCGGCGACGGGGGGGG---UGCCGCGCGCGGGUCGGGGG GCGGGGCGGACUGUCCCCAGU-GCGCCCCGG-------GCGGGUCGCGCCGUCGGGCCCG GGGG--AGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGGGGACGGCGGA-GCGA GCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CACGUGCGCGA---GUCGG--GGG--C-U-C------GCACGAA-- --------AGCC-G-CCGUGGCGCAAUGAAG-GUGAAG--------GCCGG-C------- -------GCGCU--------------C-GCCG-GC-CGA------------------GGU GGGAUCCCGAGGC-C---U--C----------U-C------CAGUCC------------- --------------------G----C--C--G--A----------GGGCGCACCACCGGC CCGUCUC---G---CCC----------------------GCCGC-------------G-- --CC--G-GGGAGGUGGAGC-AC-GAGCGCACGUGUUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U-CUCGCAGA------ ---------------------CCCGACGCACC------------------CCCG--CCA- ---CGC-------------------AGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCGU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--G-UGCCU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUCGCCG--G--CAGU-CGAGAGNGGACGGGA-GCGG---------C GGGGGCGGCGCGCGCNCGC--------GCGCGUGUGGUGUGCGUCGGAGGGCGGCGGCGG CGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCUCC UCCCGCCCACGCCCCGCUCCCCGCCCCCGGA-------------------------GC-C CCGCGGACGC-----UA----C---------GCCG-C-G-A-CG-A--GUAGGA----GG ---GCCGCU-GCGG-UGA------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCCUAG--G-GCGC-GG-GCC--CGGG-U-GGA-GCCGCC-G--CAGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UGA----GAGAUG--GGCGAG--CGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUU-----G-CCC-U--CGG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---GUGG-C-GGA--G----A--U----GG -G-C---------------G---C----------------------------------CG CGA--------------------------------------------------------- ---GGCGUC-CAG-U-G--CGGUAACGC-G----A-CCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCCU G-G------A---AU-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GUGC-C--U--U-G--G-AA-A-GCG-UCGCG-G------------------- ---------UU-CC-----------------------------G--GC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UGGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGU-CG-GU-CGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCUGGGGCG-C--GAA---GC-G-G-GG---C--UG-G-GCGC-GC-GCC- -GC-G-G---C-UGG-A-CG-AG-GCG-C-C-G-CCG-CCCCCCCCA-CGCCCGGGGCAC CCCCCUCGCGGCCCUCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCG CGCCCUCUCUCUCUCUCUCUCCCCCGCUCCCCGUCCUCCCCC----------------CU CCCCG----------------------------GGGGAGCGCCGCGUGGGGGCGGCGGCG GGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGC-CGCGGGGCCCCGGCGGC GGGGGCACG--GUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCG ACUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGC CGCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGC GCGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCG GGGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCU CCUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCG-GA--GGGG--C-C-G-CGGGCCG-G -UCCCCC--CCG----CCGG---------------------------------------- ------------------------------------------------------------ --------------------------------GU--CCGC-CCC--CGG-GGC-CGC--- -GGU-UC-CGC-GC-G--GCGCCUC---------------G-CCU---CGG-C-CGGCGC CUAG--CAG-C-CGAC-UUAGAACUGGUGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCG-CG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCCAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC ACGGUGAAGAGACAUGAGAGGUGUAGAAU-AAGUGGGAGGCC-C---------------- ----CCGGCGCCCCCCCGGUGUCCCCGCGAGGG--------------------------- --------------GCCCGGGGCGGGGUCCGCCGGCCCU------------GCGGGCCG- CCGG-UGAAAUA-CCACUACUCUGAUCGUUUUUUCACUGA-CCC-G--GUGA--GG--CG GG---------------------GGG-G-CG-AGCCC--------------CGAG----- --------GGG-C-U--C-U-CG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CUUCUGGCG- ------------------------------------------------------------ --------------------------------------------CCAA------------ ----G---CG-C-CCGG---CC---------------GCGCG------------------ -CCG--G-C-----C-GGG--CGC------------------GAC-CC-GCUCC-GGGGA -CAG-UGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AACGGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUACGAAUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--AC-----CUUUUG-G-G-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-UGU-------------------------------------------------- ------GUUGUU-GCCAUGGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGGGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------CGC-CCAGGCG--- GA--ACGAU---------------------------AC--G-GCAGC----GC-C--G-- C--GGA-G-CCUC----------------------------------------------- ------------------------------------------------------------ ------------GG--UUGGCCUCGGAUA---------------------GC-CG--G-- -U--CC--------------------CCCG---------C---CUG--U--C-CCCGC-- CGG-CGGGCCGC--CC-CC-----------------CC-CCUC--C-A--CGCGCCC--- -------CGCGCGC-----G--CG--GGAGGGCGCG-UGC--CCCGCCG-CGCGCCGGGA CCGGGGUCCGGUG-----CG-GAGUG---CCCU--U-C-GUC---CUG-GG-AAACGGGG CGCGGCCGGAGAGG-CGGCCG-CCC-C-C-UCGCC-CGUCAC-G-CACCGN--A-CGUUC GUGGG-G-AA-C-CU-GGCG-CUAAAC---CAUUC-G-UAGACGACCU-GC-UUCUGGGU CGGGG-UUUCGUACGUAGCAGAGCAGCU-----------------CCCUCGCUGCGA--- --UCUAU--U--GAAAGUCAGCCCUCG---A--CAC-AA-GGGUUUGUC----------- -------- >Latimeria_chalumnae --------------UGACAACACUUAGC-AGUGGAUC-ACU-CAGCU-CGU-G--CGU-C GAUGAAGAACUCAGC-UAGCUGCGAGAAUUA-GUGCGAAUUGCAGGACA-CG--U-UGAU CAUCAACACUUCAAACGCACCU-UCCGGCCCCGGGUUAC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------UGC-C UGUCUGAGGAUCAUUU-------------------------------------------- ----UAAUCAACUCAGAUCA-GACGUGACA-ACCCACUGAAUUUAAGCAUAUUACUAAGC --GGAGGAAAAGAAACUAACCAGGAUUCCCUCA-GU-AAC-GGCGAGUGAAGAGGGAAG- AGCCCAGCGCCGAAUCCCCGC-UCGUCUG-GC--GGGCGCGGGAAAUGUGGCGUAC---- A---------------------------GAAGACCCA----------------------- ------------CCUCCCCGGC--GCCGCU-----CGGGGG------CCC-AAGUCCUUC UG-A--------UUGAGGCU---U-AGCCCACGGACGGUGCGAGGCCGGUAGCGGCCC-- -CGGGCGCG---------C----C-GGGACCGGGUCUUCUCGGAGUCGGGUUGUUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGU-CGA-CAAGUACCGU-AGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUGAGAGG---U-AAACG-GGUGGGGUCCGCGCAGUCCGCC CGG----AGGAUUCAAC-UCGGCGUGCC---GUG-CCGGCCGCCCCGGUG------UGGC GGAUCCCCU--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ CGCGGGAACGCC--CCCGUCGGCGUGCGGGCCCCCGCCGGGUGCAUUUCCUCCGC-GGUG GUGCGCCGCGAC-CGGCUCCGGGUCGCCUGGGAUGGCUGC-----GGGCGGA---GGUAG CUGGCCU----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CUC CGGAGAUCAGUGUCUGC---------CCCCCUGCCG-----CAC-CUCG----------- -----------GC-GUCUCCCGGGGCCGUGGAA-----GAUGACCGCCGCCGCGCCC--- UCCUCUC-------CCCCC---------------------UCGGGGG------------- ------------------------------------------------------------ -----------------------------CUGAGACAGGGGCCCCCG-CUG------CCG -GCGCGACUGUC------------------------------------------------ ----------------------------------------------------------GA AUGGGGCGGACUGUCCUCAGU-GCGCGCCGG-------ACGCGUCUCGCCGCCCGGCCGG GAGGCUCUCUA---------------------------------------------UCGG GCGCCAGGGGUCUGCGGCGAUGUCGGUUUCCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CACGUGCGCGA---GUCGAA-GGG--C---------AGAGCGAA-- --------ACCC-C---AUGGCGCAAUGAAA-GUGAGG--------GCCGG-C------- -------GCGG-----------------GCCG-GC-UGA------------------GGU GGGAUCCCCACGC-CCCGU----------------------------------------- --------------------G----C--G--G--G---GGGCGCACCACC----AGCCCG UC-U-C----A---CCC----------------------GCAGC-------------G-- --UC--G-GGGAGGUGGAGC-AU-GAGCGUGCGUGAUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGUGC-U--------------- --------------------------------------------------CGAG--CGA- --ACGC-------------------AGUUUUAUCUGGUAAAGCGAAUGACUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCUU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--G-UGCCU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUGUG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUC---G------CGGGCGA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------CCGGGGCCACGA----------------------- -------------------------UGGCUAUCCCGC-G-A-CG-A--GUAGGA----GG ---GCCGCC-GCGG-UGA------------------GC-A-------------------- ------------------------------------------------------------ --------------------------------------------------------CUGA AGCCUAG--G-GCGC-GG-GCC--CGGG-U-GGA-GCUGCC-G--CGGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UAA----GAGAUG--GGCGAA--CGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUC-----G-CCC-U--CAG-C------CGAUC---GA-AA-GGGA-GUU-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---AUGG-C-GGA--G---AG--G----GG ----------------------------------------------------------CG CCGCU----------------------------------------------------GUU ---GGCGUC-CAG-U-G--CGCCAACGC-A----A-ACGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCCU G-G------A---AU-G--G--G-----U--UUG-C-ACC-GAGAG-AG--GG----G-- -C-CC--GCGC-C--C--U-G--G-AA-A-GCG-UCGCG-G------------------- ---------UU-CC-----------------------------G--GC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AAG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UAGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGC-CAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGU-CG-GU-CGG-------- ------------------------------------------------------------ -------------------------------------GCCGGGGUGCGAAGCGGUGCUGG GUACGC------------------------------------------------------ ---------GCCGCGGCU-G--G-----AC-G-A-GG---C-----G------CCGCCU- ------------CCG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------GGCGGCG-------GCGACUCUGGACG-CG---AGCC-G--- GACCCUUC-CUGU-GGAUC-------GCCUCAG--CUG------CGGCGC------GCGC GG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GC----------------------- -------------CCCCCGG---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------G-GCUG--GCGUCUCG----------------CCU---CGG-C-CGGCGC CUAG--CAG-C-UGAC-UUAGAACUGGUGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCG-CG---G-U------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC ACUGUGAAGAGACAUGAGAGGUGUAGGAU-AAGUGGGAGGCCUCGGC------------- ------------------------------------------------------------ ---------------------------------------------------------CG- CCGG-UGAAAUA-CCACUACUCUUAUCGUUUUUUCACUUA-CCC-G--GUGA--GG--CG GG---------------------GGG-G-CG-AGUCC--------------CGAG----- --------GGG-C-U--CUC-GA------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCUGGUG- ------------------------------------------------------------ --------------------------------------------ACAAG---------CG -------------CCCG--------------------GUUCG------------------ ------G-------UCGGG--UGC------------------GAC-CC-GCUCC-GGGGA -CAG-UGGCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AACCGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUAUGAGUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--AC-----UUUUUG-G-G-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-UGU-------------------------------------------------- ------GUUGUU-GCAAUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGUGCGAAGCUA-CCAUCUGU --A-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------UCC-CUAAACG--- UA--ACAAUUAAUAGCCUGUUUAGCUCCACCCUUUGAU--UGUAGCA----CU-A--G-- U--AGG-A-CAUU----------------------------------------------- ------------------------------------------------------------ -------UU---GA-ACAAUUUCAUCAUA------------------------------- ------------------------------------------------------------ ---CCUUACCUGGUC--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------UCGCUU------------------------ ------------------------------UUUU--G-AAACCUCAGAAAUCCUAAAAU- GGGGG-UUUGUCCCAGGGGUGCAACAGGUACUGCAUUGCACUACCAUGUGGGAGAUCAGG GCUCAAUCCCUGUUGUGGAUCUCCCACA-GGCAACUAACACCAAGACACAUUACAAAGGC AAUGCU-C >Leishmania_major -------------------ACGUGUCGC-GAUGGAUG-ACU-UGGCUUCCU-A--UUU-C GUUGAAGAACGCAGU-AAAGUGCGAUAAGUG-GUAUCAAUUGCAGAAUC-AU--U-CAAU UACCGAAUCUUUGAACGCAAAC-GGCGCAUGGGAGAAGC---------------UCUAUU G-----UGUCAUCCCCG------------------UGCA--------------------- -------------------------------------------------------UGC-C AUAUUCUCAGUGUCGA-------------------------------------------- --GUUUACAGACCUGAGUGU-GGCAGGACU-ACCCGCCGAACUUAAGCAUAUUACUCAGC --GGAGGAAAAGAAAACAACCGUGAUUCUCUCA-GUGAGC-GGCGAGCGAAGAGGGAACG AACUCGUUGCCGAAUCGGGUCU-UACAAG--------GCCUUGAGUUGUGGCACAA--AU AUCAU---------UUCGUGGUUGGUGCAGGAGUGGC----------------------- ---------GAAAUUCAAGCGC--AAAGCA--AACCCGUUG------CUG-AAU------ -A-CAACCCUUCAUGUGAGUAUUG-AGCC-AAAGAAGGUGUUAGCCCAUUG--------A GCCAU-AAACCUGAGCG-CCUCAU-GAA---CUGUAUUAAGCGAGUAGCACUGUUU---G GGAAUGCAGUGUCAAGUUGGCAGGUAUUUGUCUGCCAAAGUUAAAUACAGAGUAGGAAGA CCGAUAGC-GAA-CAAGUAGCGUGAGCGAAAGUUUGAAAAGCAC-UUUGGAAAGAG-AGU GAAAUAGAACCUGAAGUCGUGACAAAGA--C-AAUGG-AAGUACCUCCAUUUC------- --AA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------CGGCCAGAAC-----C-----AG----------- -----------C-----------------------------------CCUACUGCAU--- UAUCCU---------GUCG-GGGGUCAAAAUC--------CGGCGGGCA-ACGAAGU-GC --AAGAAUCU-UGGGUCUUGGUGAA--------AUG--AGC--------------GG--- ---------AGUAUUUGA---------GCUGUGCACGGCGCAAGCCG-C--------ACG CACUGG------------U-U-UCUUCUCCGU---GAU-GCUCCAUGUUGG--------- -------------------------CGAUGGAAAUGG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGCCCCCACCCGUCUUGAAACACGGACCAA GGAGUCAA-ACAGACGCGCAAGGGA---GGAGAUAUGG--U----------UGCCAG--- --------UACU-U-C-U-CUCGUACUGAAA-GGGAGAUGCAAAA-UGC----------- ------AUCU-----------------------------------------------GUG GUGUGCAC--A-C-----------------------------GUCAAA------------ -------------------------------U--C---CGUUUGAUUU------GCCCAA CA-C-C----G---ACC----------------------GGCC----------------- --CU--CCGUG-GGUUGCGU-UG-GAGUGUGCCUGUUUG-GACCCGAAAGGUG-GUGAAC UAUGCCUGAACAAGGUGAAGCCCGG-GGAAACC-CAGGUGGAGGCCUGU--AGCGAUGCU -GACGUGCAAAUCGCUCGUAUGAUUUGGGUAUCGGAGCGAAAGACUCAUCGAACCACC-U AGUAGCUGGUUCACAUCGAAGUUUCCCUCAGGAUAGCUGGUGC-U--------------- -------------------------------AG------------------UAGA----- -------------------------AGUAUUGUGCGGUAAAGCAAAUGAUUAGAGGCA-U UG--GUGUU-C--UUA--GAAUAU-CGACCUAUUCUCAAACUUUAAAUGUGCA-AA-CA- A---ACC-GUGCCU-UAGC--CAACU-------------------GCAA-G-G----C-- -CGG-A--------------------------------------------------AAGA -AAAG--AA-UUAGA--GGCACCA-AGU-GGG-CCU--UC-UUCGG-UAAGCGGAGC-AG -GCGAUG-CGGAA----UGA--ACCG--CUUAG--GGAUAUGUGGCGUCAAAACUUA--U G-G-GC-U-CAU-UCUCGA-UACG--UGAAAAGGGUGUUGGUGGAUAUGGACAGUUGGAC GGUGGCCAUGG-AAGUCGGCAU-CCGCUAAGGAGUGUGUAACAACUCACCAACC-----G AAUCCACCGGCCCCGAAAAUG-GAUGACGCUU-A-AGCCC-AAUUA--GUGAUUGCC--C AUU-AUUCCUUUGGUA---A--G----GG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------GGAAACAACUCUUGGAGAAAGUGUA------------------- -------------------------------GCCC-U-U-C-CG-A-UGUAGAUG---UG ---G-CCUG-GAGG-UU-------------------AG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------ACGA AGCUUAU--G-GCGU-GA-GCC--UAAGAU-GGA-CCGGCC-U--CUAGUGCAGAUCU-U GGUUG-GCGUA-GCA-A--AG-AUCUAA-C------------------GGAGAUAUACUC AACAUGCAACGUUGGA-UACU-GGAGCGGGG-AAGGAUUUCG-UGCCAACGGCACUCGUA CACGAGUUGUUCGGAAACUGAGCACA-AC-G-UUAUAUCGUUUUGUUAGGAAA--GUGA- -------------------------AGG-UGUGUCGGCGG--CAG-CUG-CU-------- ---------------CUCGGGUAGCUGUUCGA---------------------------- ---CUG-----G--CCAUAAC-UGA---AAAGGGGC---AA-CA-GAGA-ACCUGGG--A UUA----UAUU-CCAAAAAGAAAU-U-GCAU--GUGGGU--------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------A-G--UGGUAAUGCGA----A-ACACUUGCCAG-G-UAA-CAAA-U CAAU----CCUCC-CC-CG-G-UGAG------CUUUCUU-------UUC-ACC---AU-- -A-AUCC-ACAUCUCCGGC-UUUGCUGG------G--------G---C-UUGGGC-CUUU U-U------A---CU-U--C-UC-----GCGUUG-U-UCG-GAGCG-GG--GG----C-U -C-A---A-GA-U--U--G-A--A-AA-AUGCA-GCUCU--------------------- ---------CC-CU-----------------------------A-CGU-ACU--GU---C AUUGUU-GUG----AG-U----U-CUGCGCAU-UAA-A-GCAAAAAC-C--UGG------ -----------------------------GGUG--------------------------- -U--CCCA-ACU--GC-A-GACCGUACUCAUCACCGCAUCAGGUCCCCA-AGC-AUAGAA -U-GCUCUGG-UA-CA-UAGA-GAAAGGUACACUCAGGGAAGUCGGCAAAA-UAGAUGCG UAAGUUCGCA-AGAAGCAUUGGCUC-UG--A-GG-GCAAAGU-CA-GA-GA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAACCGGAAGGCC-A--GUGU---C-C-U-CU---C--G--C-A-U--GC-AGC- -C--G-U---U-CUU-C-AGAUG--UUGU-U-U-UGG-CGCU-C---------------- ------------------------------------------------------------ -----------------------------------------------------------G CC-GCC----------------------------UU-AGCAC-GC-UG---AU-A-G-C- G-AC-UGUACUGU-CGUCU-----G-U---GAA--G-G------CUACCUUCCCGAGGCG UC-GUAACC--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CGGCGUCUCACUCUGGCACGGGC---CGGU-CUU--- ---------------GGC------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGG--UU-C----- -A------C-G--CUC--GUCUUGU---------------G-CCG---CGU-C-CCA--- CAAA--UUG-C-CAAC-UCAGAACUGCUUACGGC--GGGGAAUCCAA-----CUGUAUAA UUAAAACAUAGGUUUGUGA-UG--CAU-CC---AAG------------UGGUGUAUA-UC GCAAACUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAC-GUGAC-------------GAG A---------------UUCAC-CGACGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCUUC-CAAUUAGAGACGCGCAUGAAUGGAUUAAUG AG-A--UUCCC--UCUGUCCCGA-GU-UAC-UAUCUAGCGAAACGACAG--UCAAGGGAA CGGACUUGAAGGGCUAAGCGGGGAAAGAAGA-CCCUGUUGAGU-UUGACUCCAGUCUGGC UCUGUGCGGCGACAUCUGAGGUGUAGUAU-AGGUGGAAG-CG------------------ ------------------------------------------------------------ ----------------------------------CA-----------------AG--CG- CAAA-UGAAAUA-CCACCACUCGGAACGUUGCUUCACUUA-UCG-A--AUGA-AGA--GA CC-----------------------A-A-UG-GGUUAAGCG------UAGUCUUC----G -GG--CUAUGCAC-CGUC-U--A------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGUUUGGGAGUAAUUUUAUGGCG- GUAACCCCGUCCCCACGGGAAAGGGUGGUGUGCUUUUUCUGCGUGCGUCUUCACGGGCGU CGCGCGGGCCCCGCUCUUUUUUAUUGCGUUUCCUUCGGGGGGCGUGAC-UCGUGGGUACC CAACC--GUG---CUGU---AAA-CUGAACCA------ACGG-----G---AUUGCC--- U--C--G-------U-GCA--GU---------------UCCGGAGUCU-UGUUU-CGAGA -CAUCUGCCAGAUGGGGAGUUUGGCUGGGGCGGCAUAUCUGUUA-CACGACAAC-GCAGG UGUCCUAAGGCGAGCUCAGUGGGAACAGAAAUCUCACGUA-GAACAC-AAGCGUAAAA-G CUUGCUUGAUUAACGAUUUCC-A---GUACGAAUCGAGACUGCGAAAGCAAGGCC--AGC G-AUCCUUUG----------------------CGAA--G------AAUAGG-AAAUAU-- ---------------------GAACAAAUCAUACCAGAGGUGU-CAG--AAUAAUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAACCUAGCGCCGCAGAAGACGCUAAGGGUUGGAUUGUUCACCCA CUGACAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUGGUGAGAUUGUGAA- --AGG--GAUCUCGC--------------------------------------------- -----AGGUAUC-GUGAGGGAAGU-AUUGGGGUAGUACGAGAGGAACUCCCAUGCCGUGC CUC-UAGUUUCUGGGGU-UUGUCGAAC--GGCA-AG--UGCCCCGAAGCCA---UCGCAC GGU-GGUUCUCGGCUGAACGCCUC--U-AAGCCAGAAGCC------AAU-CCCAAGA--- --CCAGAUG---------------------------CC--CACCUCCCAUGCCGUGCCUC UAGUU-UCU--------------------------------------------------- ---------------------------------------GG-GGUUUGUCG--------- ------AAC---GG--CAAGUGCCCCGAA---------------------GCC-A--U-- -C--G--------C------------ACGGU------GG---UUCUCGGC-UGA-A-C-- G--CCUCUA--AGCCAGAAGCCAAUCCC-A-----AGACCAGAU----GC-CCAC--U-C --AUCGAAUC-GCCAC---CUACAA--------GACUGG-A--GC-----U--UG--CUC C-CUCGA----------------------------------------------------- ---------AGG--CGCCAAGUAUAUUCAUG------------AUCACA----------- ----------AGAC---AG---UCCCU---CUCC--A-AACGAGAGAA-CA-UGCAUGGG CUGGC-AUGAGCGGCAUGCUUCACUUCGGUGGGGCU----CGAGGGGCA---UUUAC--G UCCCGAG--G--CGCUG-----AACCU--UGAGGCCUGA-AAUUUC-AU--GCU-CAG-G GACAC--- >Monodelphis_domestica ------------------AACUCUUAGCGGGUGGAUCUACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-AUGUGAAUUGCAGGACACCA--U-UGAU CAUCGACACUUCGAACGCACU--UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------CGC-C UGUCUGAGCGUCGCU--------------------------------------------- -----UGCGACCUCAGAUCA-GACGUGGCG-ACCCGCUGAAUUUAAGCAUAUUAGUCAGC GAGAGAGAAAAGAAACUAACCAGGAUUCCCUCA-GU-AAC-GGCGAGUGAACAGGGAAG- AGCCCAGCGCCGAAUCCCCGC--CCCGCG-GU-GGGGCGCGGGCCAUGUGGCGUAC---- ----------------------------GGAAGACCC----------------------- ------------ACUCCCCGGU--GCCGCUCUCGGUGGGGG------CCC-AAGUCCUUC UG-A--------UCGAGGCA---C-AGCCCGUGGACGGUGUGAGGCCGGUAGCGGCCC-C -CG-GCGCG---------C----CGGGGACCGGGUCUUCUCGGAGUCGGGUUGCUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGUCCAA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAACUUUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUGAGAGG---U-AAACGAGGUGGGGUCCGCGCAGUCCGCC CGG----AGGAUUCAAC-CCGGCGGUCCCU-GGC--CGGCCGUGCCGGUGGUUUCCGGCG AGAUCUUUCCCGCCCCUCGUUCUUCCCGACCCCUCCACC--------------------- ----------------------------ACGUCGCCCCGCGAGGG--GCGGCGGGC---- -----------------------------------GAGGGCCGGGGAGUGAGGU-GCCCG CGGGGGACCGCCCCCCCGGACGGAGCCCGGCCGCCGCCGGGCGCAUUUCCACCGA-GGCG GUGCGCCGCGAC-CGUCUCCGGGACGGCUGGGAAGGCCGGGCUUUUCCCUG----GGCAG GUGGCUCGGGGGUGGCGGGGGCCAGAGGGGGCCCGGGUCGCCGUGUGGGGUGGCGGGGUC GGUCGGUCCGCCGGCCGGC---------------CUCGUCUUCCCCUCGGC--GCCCG-- ---------CCUCUCGUGGGUCCUCC---------------------------------- -----GCCGUCGCAGC-----------------------------------------CCC CGAGUGUUAUAGCCCC----------CCGGCAGUAG-----C-U-CUCG----------- -----------CCAGCAUCCCGGGGUCGAGGAA---A-GAUGACCGCCGCCGCGGCUU-- UCCCCCGCCGGAGCCCCUC-CGCCGCCCGUCG--------CCGCC--------------- -------------CCUCGC-GGGUGGG-----------GGCGGGU-GCGCCGG--UGCGG G--------CCCGGGUUC---------CCGGGGGACGGGCCGCCCCU-CCC------CCG -GCGCGACUGCUCUCCCC------------------------------------------ --------------------------------------------------------GAAA CCGGGGCGGACUGUCCUCAGU-GCGCCCCGA-------CCGCGUCGCGCCGCCGGGCUCG GGGA---------------CCGCUGCUCUCGUCGCA--------------------CGAG GCGCCCGGGGUCAGCGGCGAUGUCGGCCCCCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CACGCGCGCGA---GUCAG--GGG--C-UCC------GCACGAA-- --------AGCC-ACCCGUGGCGCAAUGAAG-GAUGAA-------GGCCCG--------- -------GCGCC--------------C-GCCG-GC-CGA------------------GGU GGGAUCCCGAGGC-C---U--CGGUCCUUCUUC-C------CGUCCU------------- --------------------G----C--C--G--A----------GGGCGCACCACCGGC CCGUCUC---G---CCC----------------------GCCCC-------------G-- --CC--G-GGGAGGUGGAGC-AU-GAGCGUGUGUGUUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U-CUCGCAGUGGUCGU CCGGUCGGAGCGGGGGAGCGCCCCCCUCCCUCGGGGGGCGGGGGUU----CCCC--UGG- ---CAC-------CCGCCGCCACGCAGUUUUAUCCGGUCAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCUU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--G-UGCCU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUCGCUGGCA-AUGGGCAAAAGCAGGAACAGAAACGUGUUGUUUCCC GAGAACGGAUUCCGCGCGC----------------------------------------- -----------GGGAGGAAGG--------------------------------------- -------------------------CGCGAACUC----------------------AC-U CCUCGGGGGC-----UA-------------GGCCG-C-G-A-CG-A--GUAGGA----GG ---GCCGCC-GCGG-UGG------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UGGA AGCCUAG--G-GCGU-GG-GCC--CGGG-U-GGA-GCCGCC-G--CGGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UGA----GAGAUA--GGCGAG--CGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUU-----G-CCC-U--CGG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---GUGG-C-GGA--G----A--C----GG -G-C---------------G---C----------------------------------CG UGA--------------------------------------------------------- ---GGCGUC-CAG-U-G--CGGUAACGC-G----A-CCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---GC---CG--CCCU G-G------A---AU-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GCGC-C--U--U-G--G-AA-A-GCG-UCGCG-G------------------- ---------UU-CC-----------------------------G--GC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UGGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGU-CGGUC-GGG-----CUG GGGCGCGA-AGCGGGGCUGGGCGCGCGCCGCGGCUGGACGAGGCGCCGCCGCUCCCCCUC CCGGCGCUCUCCCGCCGGACGCCUCCCCGCGGCCCCCCCGCCCGCUCCCCGCCGGGUUCC CUU---------CCCCGCGGC---------------------UCCCCUGGCCUCCCCCCC UCCCACGCCUCCCCGCCG-GC-CAAA--CC-G-C-GG---CGGUG-GCGGGCGGG----- -GG-GGGA--CGGGG---GG-GGCGCGCGGGGGGUCG-----------GGGGCGCGGGUC CCGCCCGCGUCUCCCCUCCCUCCCGCCCCCCCUCGCUCCUCUCCCACCCUCCCCACCGCG ------------------------------------------------------------ ---------------------------GCGGUGGGGGGGCAGGGGGGGGGAUCGGCGCCA GGGGGUUCCAAGUCGCGGGGUCGGC--CCGGCGGGGGUUGGUCGGUGCGGUCGGGGUCCG GGGUUCGGG--------CCCGGCGGGUGCCCGGGAA-CCGGGGGUC-GGCGGCGGCGGCG ACUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGC CGGGCCCGGGGAGCC---CGGGGGCGGGCCUGCUCGGCCCGCCGGCC------------- ------------------------------------------UCGGGGGGGUCUGCCCUG GGGCGC-------------------------GCGCGGCUCCCCGCCCGCGGCCCCCCUC- ----------------CGGGGGGUGUCGGCGGCGGGG-UGGGU--C-C-G-CGCGCCCCG GGUGCCCCUCCGGCCGCGGG---------------------------------------- ----------------------------------------------AUCUG--------- -----------------------------UG-GCGGCCCUCCCCCCCCGGGUGCCCCCCC GGGCCUCGGUC-CCCGCGGCGUCCC---------------G-CCU---CGG-C-CGGCGC CUAG--CAG-C-UGAC-UUAGAACUGGUGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-GGGCCCG-CG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUCUUAAUUAGUGACGCGCAUGAAUGGAUGAACG AA-GAUUCCCC--ACUGUCCCUA-CC-UACUUAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCCUGUUGAGC-UUGACUCUAGUCUGGC ACGGUGAAGAGACAUGAGAGGUGUAGAAUAAAGUGGGAGGCC-C--C------------- ----CCAGGUGCCCCCCGGGGCCCCGCCCCCGGGCUCCCCCGCGAGGAGGAUCCCCCGGG UCGGCGGGCCCCCCCCCGGGGUCGGCGAGCCGGCCUUCC------------GGGC--CG- CCGG-UGAAAUACCCACUACUCUGAUCGUUUUUUCACUGA-CCC-G--GUGA--GG--CG GG---------------------GGGAG-CG-AGCCC--------------CGAG----- --------GGG-C-U--C-U-CG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CUUCUGGCG- ------------------------------------------------------------ --------------------------------------------CCAAG----------- --------CG-C-CCGG---CC---------------GCACGG----------------- -CGC--G-------CCGGG--CGC------------------GAC-CC-GCUCC-GGGGA -CAG-UGUCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCACAACCGUAACGGCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUAUGAAUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--AC-----CUUUGG-G-G-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-GGG-------------------------------------------------- ------GUUGUC-GCCAUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUUAUGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGGGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUCCGU-AAGUCAGAAUCC------CCC-CUAAGCG--- UG--ACGAU---------------------------AC--C-GCAGC----GC-C--G-- A--GGA-G-CCUC----------------------------------------------- ------------------------------------------------------------ ------------GG--UGGGCCACGGAUA---------------------GC-CG--G-- -G---------------------------------------------------------- ----CUGCCCGUGCUCCCUCCCUCUGUUUC------------------------------ -------------------GGCGGG-----------------------GGGGCCUCGGGG GCCGGGGCCCGGU-----GCGGAGGG---CCGU-UCGC-GCC-------GGGGGCUGGAG AGCGGCCGCGAAGGGGGGCCGCCUCUCAC-CCGGAGCGCAGC----------GCAUGUUC GUGGG-G----CACCUGGUG-CUAAAU---CAUUC-G-UAGACGACCU-GC-UUCUGGGU CGGGG-UUUCGUGCGUAGCAGAGCAGCU-----------------CCCUCGCUGCGA--- --UCUAU--U--GAAAGUCAGCCCUUG------ACACAA-GCUUUUGUC----------- -------- >Mus_musculus ------------------GACUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-AUGUGAAUUGCAGGACA-CA--U-UGAU CAUCGACACUUCGAACGCACU--UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------CGC-C UGUCUGAGCGUCGCUUG------------------------------------------- -----CGCGACCUCAGAUCA-GACGUGGCG-ACCCGCUGAAUUUAANCAUAUUAGUCAGC --GGAGGAAAAGAAACUAACCAGGAUUCCCUCA-GU-AAC-GGCGAGUGAACAGGGAAG- AGCCCAGCGCCGAAUCCCCGC--CGCGCG-UC-GCGGCGUGGGAAAUGUGGCGUAC---- ----------------------------GGAAGACCC----------------------- ------------ACUCCCCGGC--GCCGCU--CGUGGGGGG------CCC-AAGUCCUUC UG-A--------UCGAGGCC---C-AGCCCGUGGACGGUGUGAGGCCGGUAGCGGCCC-C -CG-GCGCG---------C----C-GGGCUCGGGUCUUCCCGGAGUCGGGUUGCUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGU-CAA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGUCCGCGCAGUCCGCC CGG----AGGAUUCAAC-CCGGCGGCGCGC-GUC--CGGCCGUGCCGGUGG--UCCCGGC GGAUCUUUCCCGCUCCCCGUUCCUCCCGACCCCUCCACCCGCGCGUCGUUCCCCUCUU-- --------C---------CUCCCCGCGUCCGGCGCUCCGGC--------GGCGGG--CGC GG--------GGGGUGGUGUGGUGGUGGCGCGCGGGCGGGGCCGGGGGUGGGGU---CGG CGGGGGACCGCC-CCCCGGCCGGCGACCGGCCGCCGCCGGGCGCACUUCCACCGU-GGCG GUGCGCCGCGAC-CGGCUCCGGGACGGCCGGGAAGGCCC-------GGUGG----GGAAG GUGGCUCGGGGGGGGCGGCG---------------------------------------- CGUC-------------------------------UCAGGGC-----------GCGCCGA ACC--------------------------------------------------------- ---------------------------------------A-CCUCA-----------CCC CGAGUGUUACAGCCCU----------CCGGCCGCAG-----C-U-UUCG----------- -----------CC-GAAUCCCGGGGCCGAGGAAGCCA-GAUACCCGUCGCCGCGCUC--- UCCCUC---------UCCC-CCCGUCCGCCUC--------CCGG---------------- ----------------------GC------------------------------GGGCGU GGGGGUGG-G----------------------GGCCGGGCCGCCCCU-CCC------ACG -GCGCGACCGCUCUCCCAC-C-CCCCUCCGUC---G---CCUC---UCUCG--------- ---------------------------------------------GGGCCCGGUG-GGGG GCGGGGCGGACUGUCCCCAGU-GCGCCCCGG------GCGUCGUCGCGCCGUCGGGUCCC GGGGGGACCGUCGGU----------CACGCGUCUCCCGACGA-----------AG-CCGA GCGCACGGGGUCGGCGGCGAUGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CGCGUGCGCGA---GUCAGG-GGC--U-C--------GUCCGAA-- --------AGCC-G-CCGUGGCGCAAUGAAG-GUGAAG--------GGCCC--------- -------CGCCC--------------G-GGGG-CC-CGA------------------GGU GGGAUCCCGAGGC-C---U--C----------U-C------CAGUCC------------- --------------------G----C--C--G--A---GGGCGCACCACC----GGCCCG UC-U-C----G---CCC----------------------GCCGC-------------G-- --CC--G-GGGAGGUGGAGC-AC-GAGCGUACGCGUUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U---CUCGCU------ ---------------------CUUUUUUUUUNC-----------------CGAC--GUA- ---CGC-------------------AGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCGU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--G-UGCCU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUCGCCGGCA-GUCGGAACGGAACGGGACGGGA-GCGG--------- CCGCGGGUGCUCGUCU----CUUG------------------------------------ ----------------------GGGUCUGGGGGGCGUGGCGGGGGCCCGUCCCCCGCCUC CCCUCCGCGCGCCGGGUUUCGCCCCCGCGGCGUCGG----------------------GC -CCCGCGGACGC-----UA----C---------GCCG-C-G-A-CG--GUAGGA----GG ---GCCGCU-GCGG-UGA------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCCUAG--G-GCGC-GG-GCC--CGGG-U-GGA-GCCGCC-G--CAGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UGA----GAGAUG--GGCGAG--UGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUU-----G-CCC-U--CGG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---GUGG-C-GGA--G----A--U----GG -G-C-------------------------------------------------------G CCG------------------------------------------------------CGA ---GGCGUC-CAG-U-G--CGGUAACGC-G----A-CCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCCU G-G------A---AU-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GUGC-C--U--U-G--G-AA-A-GCG-UCGCG-G------------------- ---------UU-CC-----------------------------G--GC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGGCAU-GU-UGGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGU-CGGUC-GGG-------- ---------CUGGGGCGCGAAGCGGGGCUGGGCGCGCGCCGCGGCUGGACGAGGCGCCGC CGCCCUCUCCCACGUCCGGGGAGACCCCCCGUCCUUUCCGCCCGGGCCCGCCCUCCCCUC UUCCCCGCGGGGCCCCGUCGU---------------------CCCCCGCGUCGUCGCCAC CUCUCUUCCCCCCCUCCU-U--C-UU---C-C-C-GU---CGGGG--G-GCGG-GU-CGG --G--G-G---U-CGG-C-G--CG-CGG-CGC-G-GGC-UCCGGGGCG-GCGGGUCC--A ACCCC------------------------------------------------------- -----GCGGGGGUUCCGGAGCGGGAGGAACCAGCGGGCCCCCGGUGGGGCGGGGGGCCCG GACAC-U--CGGGGGGG-CC-GGCGGCG--GCG--GCGACUCUGGACG-CG---AGCC-G -G-G-CCCUUC-CCGU-GGAU------C-GCCUCAG--CUG------CGGCGG------G CG--U-CGCGG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CCGCUCCCGGGGAGCCCGG-CG--GGUG--C-C-G-GC-GCG GG--UCCCCU--CCC-CGCGGGGCCUCGCUCCACCCCCCCAUCGCCUCUCCCGAGGUGCG UGGCGGGGGCGGGCGGGCGUCCCGCGCGUGUGGGGGGAACCUCCGCGUCGG--------- -----------------------------UG--UUCC-CCC--GCC-GGG-UCCGCC--- --CC-CCG--G-GCCGCGGUUUUC----CGCGCGGCGCCUCGCCU---CGG-C-CGGCGC CUAG--CAG-C-CGAC-UUAGAACUGGUGCGGACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCG-CG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCCAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC ACGGUGAAGAGACAUGAGAGGUGUAGAAU-AAGUGGGAGGCC-C--C------------- ---------CGGCGCCCGGCCCCGUCCUCGCGU--------------------------- --------------CGGGGUCGGGGCACGCCGGCCUCGC------------GGGC--CG- CCGG-UGAAAUA-CCACUACUCUCAUCGUUUUUUCACUGA-CCC-G--GUGA--GG--CG GG---------------------GGG-G-CG-AGCCC--------------CGAG----- --------GGG-C-U--CUC-GC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCUGGCG- ------------------------------------------------------------ --------------------------------------------CCAAG----------- ---CG--UCC-G-UCCCG---CG----------------CGUG----------------- ----C--G-G-----GCGGG--CGC-----------------GAC-CC-GCUCC-GGGGA -CAG-UGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AACGGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUACGAAUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--AC-----CUUUUG-G-G-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-UGU-------------------------------------------------- ------GUUGUU-GCCAUGGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGGGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------CGC-CCA--G---- ----GCGGA---------------------------AC--GA--U------AC-G--G-- C--AGC-G-CCGA----------------------------------------------- ------------------------------------------------------------ ------------AG----------------------------------------G--A-- -G--C--CUCG------G---U-UGGC--C-CCGGA-UAGC-CGGGUCCCCGUCCGU--- -------------CC-CCGC--U-C--GGC--------------GGGGU---CC-----C --CG--CGUCGUCCC----CGC--GGCGGCGCGGGGUCUCCCCCCGC-CGGGCGUCG-GG ACCG-GGGUC-CGGU--G-CGGA-GA-GCC-GU--U-CGUCUUGGGAAACGGGGUG-CGG CCGGAAAG--G-G-GGCCG--CCCUC--U-CGCCCG--U--CACGUUGAA-CGCA--C-G U-UC---GUGU-GGAACCUGGCGCU-AAACCAUU--CGUAGACGACCU-GC-UUCUGGGU CGGGG-UUUCGUACGUAGCAGAGCAGCUCCCUCGCU---------GCGA----------- --UCUAU--U--GAAAG----UCAGCC--CUCGACACAA-GGGUUU-GUCUCUGC-GGGC --UUUC-- >Oryza_sativa -------------CACACGACUCUCGGC-AACGGAUA-UCU-CGGCU-CUC-G--CAU-C GAUGAAGAACGUAGC-GAAAUGCGAUACCUG-GUGUGAAUUGCAGAAUC-CCG-U-GAAC CAUCGAGUCUUUGAACGCAAGU-UGCGCCCGAGGCCAUC---------------C----- ----------GGCCGAG------------------GGCA--------------------- -------------------------------------------------------CGC-C UGCCUGGGCGUCAC---------------------------------------------- ------GCGACCCCAGGUCA-GGCGGGACU-ACCCGCUGAGUUUAAGCAUAUAAAUAAGC --GGAGGAGAAGAAACUUACGAGGAUUCCCCUA-GU-AAC-GGCGAGCGAACCGGGAGA- UGCCCAGCUUGAGAAUCGGG-CGGC-------CGCGCCGUCCGAAUUGUAGUCUGG---- ----------------------------AGAGGCGUC----------------------- ------------C------UCA--GCGACG----GACCGGG------CCC-AAGUC-CCC UG-GA-------AAGGG------G-CGCC-UGGGAGGGUGAGAGCCCCGUCCGGCCCGG- -AC-CC-UG---------UCGCCC-CACGAGGCGCCGUCAACGAGUCGGGUUGUUU---G GGAAUGCAGCCCAAAU-CGGGCGGUAAACUCCGUCCAAGGCUAAAUACAGG-CG-AGAGA CCGAUAGC-GAA-CAAGUACCGCGAGGGAAAGAUGAAA-AGGAC-UUUGAAAAGAG-AGU CAAAGAGUGCUUGAAAUUGCCGGGAGG---G-AAGCG-GAUGGGGGCCGGCGAUGCGCCC CGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------C-CGUAUGCGGAACGGCUUCGGCUGGUC-------CGC--------CGA UCGGCUCGGGG------------------------------------------------- ----CGUGGACUGUUGU------------------------------------------- ------------------------------------------------------------ ---------------CGGCCGCGCCGGCGGCC------AA-AGCC--------------- CGGG-GGCUCCGCGCCC---------CCGGCAGCCG-----U-C-GUCG----------- -----------GC-GCAGCC----------------G-GUCACCGC----GCGCCUC--- UG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------G--------- ------------------------------------------------------------ ---------------------CGCGCCCCUC------GGGGCGCUGCGCCGCAACGGCCU G----------------------------------------------------------- -----CGGGCU-----------------CCCCAUCCGACCCGUCUUGAAACACGGACCAA GGAGUCUG-A----CAUGCGUGCGA---GUCGAC-GGG--U----------UCUGAA--- --------ACCU-G-G-GAUGCGCAAGGAAG-CUGACG---------------------- ---------------------------------------------------------AGC GGGAGGCC--C-------------------------------UCAC-------------- ----------------------------------G---GGCCGCACCGCU----GGCCGA CC-C-U----G---AUC----------------------UUCU----------------- --GU--GAAGG-GUUCGAGUU-G-GAGCACGCCUGUCGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGCGGGGCGAAGCCAGA-GGAAACU-CUGGUGGAGGCUCGA--AGCGAUACU -GACGUGCAAAUCGUUCGUCUGACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGAGC-C--------------- -------------------------------CA-------------------UU--A--- ---CG--------------------AGUUCUAUCGGGUAAAGCCAAUGAUUAGAGGCA-U CGG-G-GGC-G--CAA--CGCCCU-CGACCUAUUCUCAAACUUUAAAUAGGUA-GG--A- C---GGC-GCGGCU---GC-UCCGGU-------------------GAGC-C-G----C-- -G-C-C--------------------------------------------------ACGG -AAU---CG-G--GA--G-CUCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGGAAGCCU--GGUUACG--GUGCC--GAACUG--C G-C-GC-U-AAC--CUAGA-ACCC--ACA-AAGGGUGUUGGUCGAUUAAGACAGCAGGAC GGUGGUCAUGG-AAGUCGAAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCCGAAAAUG-GAUGGCGCUG-A-AGCGC---GCG--------ACC--C ACA-CCAGGCC--AUC---U--G----GG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GAGCGCCAU-------------------------- -------------------------------GCCC-C-G-A-UG-A--GUAGGA----GG ---G-CGCG-GCGG-CC-------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------GCAA AACCCGG--G-GCGC-GA-GCC--CGGG-C-GGA-GCGGCC-G--UCGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GGCC-GAAGAGGAG-AAAGGUUCCA-UGUGAACGGCACUUGCA CAUGGG------------UAAGCCGA-UC-C-UAA----GGGACG--GGGUAA--CCCC- ---------------------------G-G-C--AGA-----GAG-CGC-G--------- ---------------------------ACCA----------------------------- -----------C--GC-G--C-G-U------GCCCC---GA-AA-GGGA-AUC-GGG--U UAA----GAUUUCCC----GAGCC-G-GGAC--GUGG-C-G------------------- -----------------------------------------------------------G UU---------------------------------------------------------- --------------G-A--CGGCGACGU-U----A-GGAAGU-CCGG-A-GAC-GCCG-G CGGG----GGCCU-CG-GG-A-AGAG------UUAUCUU-------UUC-UGC---UU-- -A------ACG------GC-C------C------G--------C---C----AA--CCCU G-G------A---AA-C--G--G-----U--UCA-G-CCG-GAGGU-AG--GG----U-- -C-CA--GCGG-C--C--G-G--A-AG-A-GCA-CCGCA--------------------- ---------CG-UC-----------------------------G-CGC-GGU--GU---C CG-GUGCGCC----CC-C--G-G-CGGCCCUUGAAA-A-UCCGGAGGAC--CGAGUAC-- ------------------------------------------------------------ -C--GUCC-ACG--CC-C-GGUCGUACUCAUAACCGCAUCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CC-AA-UGGA-ACAAUGUA-GGCAAGGGAAGUCGGCAAAA-CGGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-UG--A-GG-GCUGGGC-UC-GG-GGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------UCCCGGCCC-C--GAA----C-C-C-GU---C--G--G-C-U--GC-CGG- -C--G-G---A-CUG-C-U--CG--AG-C-U-G-C------------------------- ------------------------------------------------------------ -----------------------------------------------------------U CG-C----------------------------------GCGG-CG-AG---AG-C-G-G- G-CC-GCC-GCGU-GC-C------G-G---CCG--G-G------GGACGG------ACC- -G-GGAACG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCCCC---------------------------- ---------------CUCG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------G--G-G--GCC--U----------------U-CCC---CGG-G-CGU--- CGAA--CAG-C-CGAC-UCAGAACUGGUACGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUUGCGA-UGGUCC--UC---G-CGGAUGCUGACGCAAGUGAUUC-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUG-UC-UAC-UAUCCAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCCGAC UUUGUGAAAUGACUUGAGAGGUGUAGGAU-AAGUGGGAG-CC------------------ ------------------------------------------------------------ ----------------------------------CUCG---------------GG--CG- CAAG-UGAAAUA-CCACUACUUUUAACGUUAUUUUACUUA-UUC-C--GUGA--GU--CG GA-----------------------A-G-CG-GGGC----------------CUG----- ---------GC-C-C--C-U--C------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CUUUUGGCU- ------------------------------------------------------------ --------------------------------------------CUAA------------ ----G--GCC---C--G---AG----------------UCCC------------------ ------U-------C-GGG--CC-------------------GAU-CC-GGGCG-GAAGA -CAU-UGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AAAGAUAAC-GCAGG UGUCCUAAGAUGAGCUCAACGAGAACAGAAAUCUCGUGUG-GAACAA-AAGGGUAAAA-G CUCGUUUGAUUC-UGAUUUCC-A---GUACGAAUACGAACCGUGAAAGCGUGGCCU-AUC G-AUCCUUUA-------------------------G--AC-----C-UUCG-GAG-UU-- ----------------------------UGAAGCUAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUUCAUAGCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGUGUUGGAUUGUUCACCCA CCAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG--A-C-------------------------------------------------- ------CGUGCC-GCGAUAGUAA--UUCAACCUAGUACGAGAGGAACCGUUGAUUCACAC AAU-UGGUCAUCGCGCU-UGGUU-GAAA-AGCC-AG--UGGCGCGAAGCUA-CCGUGUGC --C-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------AAG-CUA--GCA-- -A--GCGGC---------------------------GC--CUGCG------CC-C--G-- C--CGC-C-CGCC----------------------------------------------- ------------------------------------------------------------ ----------------CCGACCCACGUUA---------------------GG--G--G-- -C--UA---------------GGGGCGCA--------------------------A-G-- C--CCCCAA--GGGCCCGUGCCACCGGCCAA-----------------GC-CGGC--C-C --GGC--------------CGACGC--------------------G----C--CG--CG- GCCGGC------------------------------------------------------ ---------CGC--CUCGAAGCUCCCUUCCC----------------------------- AACGGGCGG-CGGG-----CU-GAAUC---CUUU--G-CAGACGACUU-AA-AUACGCGA CGGGGCAUUGUAAG-UGGCAGAGUGG--C-C--------------UUGCU--GCCAC--G -AUCCAC--U--GAGAUCCAG--CCCC--GC-GU-CGCA-CGGAUU-CG--UCCCUCCCC CCUCUC-- >Pan_troglodytes -----------------UGACUUUUAGC-GGUGGAUC-ACU-UGGCU-CCU-G--CGU-U GAUGAAGAAUGCAGC-UAGCUGUGAGAAUUA-AUGUGAAUUGCAGGACA-CA--U-UGAU CAUCGACACUUCGAACGCACU--UGCGGCCCGGGUUCC----------------U----- -----------CCCAGG------------------GCUA--------------------- -------------------------------------------------------UGC-C UGUCUGAGCUUUCCUU-------------------------------------------- ----GCGUGACAUCAGAUCA-GACGUGGUG-AUCCAUUGAAUUUAAGCGUAUUAGUGAGC --GGAGGAAAAGAGACCAACCAGGAUUCCCUUA-GU-AAC-AGUGAGUGAAGAGGGAAG- AGCCCAGUGCUGAAUCCCUGC--CUUGUG-GU-GGGGUGUGGGAAAUGUUGCAUAU---- ----------------------------GGAAGGCCC----------------------- ------------UGUCCCCGGC--ACCGCU--GGUGGGUGG------CCC-AAGUCC--- UG-A--------UCUAGGCC---A-AGACUGUUGGUGGUGUGAGGCUGGUAGCCACCCC- -UG-GCGCG---------C----U-GGGCCCGGGUCUUCCUGGAGUUGGGUUGCUU---G GGAAUGCAGACCAAAG-GGGGUGGUAAAC---AUCUAAGACUAAAUACUGA-CA-CGAGA GCGAUAGU-CAA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGUCCGCGCAGUCCGCC CGG----AGGAUUCAAC-CCGGCGGCG---GGUC--CGGCCGUGUCGGCGG---CCCGGC GGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCUCCACCCGCCCUCCCUUCCCCCCGC-- ------------------CGCCCCUCCUCCUCCUCCCCGGAGG-G----GGCGGG--CUC CG----------GCGGGUGCGGG---GGUGGGCGGGCGGGGCCGGGGGUGGGGU---CGG CGGGGGACCGUC-CCCCGACCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGC-GGCG GUGCGCCGCGAC-CGGCUCCGGGACGGCUGGGAAGGCCC-------GGCGG----GGAAG GUGGCUCGGGGGGCCCCGUC---------------------------------------- CGUCCUCC------UCC------------------UCCCC-CCCCGUCUCC--GCCCC-- ---------CCGGCCCCGCGUCCUCCCCCGGGAGGGCGCGCG-GGUCGGGGCGGUGGCGG C---GGCGGCGGCGGUGGCGGCGGUGGCGGCGGGACCGAA-ACCCC-----------CCC CGAGUGUUACAGCCCC----------CCGGCAGCAG-----C-A-CUCG----------- -----------CC-GAAUCCCGGGGCCGAGGGAGCGA-GA--CCCGUCGCCGCGCUC--- UCCCCC---------CUCC-CGGCGCCCACCC--------CCGCG-----GGGAUAUCCU CCGCGAGGGG-GGUCUCCC-CCGCGGG-----------GGC-----GCGCCGG------- ------CG-UCUCCUCGU---------GGGGGGGCCGGGCCACCCCU-CCC------ACG -GCGCGACCGCUCUCCCAC-C-CCUCCUCCCC---GCAACCCC----------------- --------------C-CUCUCCCGGCGACGGGGAGGG-----CCGCGCGCGGGUCGGGGG GCGGGGCGGACUGUCCCCAGU-GCGCCCCGG-------GCGGGUCGCGCCGUCGGGCCCG --GGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGGGGACGGCGGAGCCGA GCGCACGGGGUCGGCGGCGAUGUCGGCCACCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CACGUGCGCGA---GUCGGG-GGC--U-C-G------CACGAA--- --------AGCC-G-CCGUGGCGCAAUGAAG-GUGAAG--------GCCGG-C------- -------GCGCU--------------C-GCCG-GC-CGA------------------GGU GGGAUCCGAGGCC-UCU-CC-A----------G---------UCCGCC------------ -------------------------------G--A---GGGCGCACCACC----GGCCCG UC-U-C----G---CCC----------------------GCCG----------------- -CGC--CGGGGAGGUGGAGC-AC-GAGCGCACGUGUUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGC-AAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- -------------------------------CU------------C-----GCA--GA-- --CCC-GACGCACACCCCCCCACGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCGU-------------------GGAG-C-C----G-- -G-G-G---------------------------------------------------UGG -AAU----G-C--GA--G-UGCCU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC-CG A-C-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUC---G--CC---GG-C------AGUCGAGA-GUGG---------- ----ACGGGAG----CGGC----------------------------------------- ------------------------------------------------------------ ----------------------------GGG-------------------------GGCG GCGCGGGCGUGUGCGCG----C---GCGCGUGUGUGC-G-UGUG-U--GUCGGA----GG ---GCGGCG-GCGG-UGG------------CGGCGGGGGU-GGGGUCCUCCCCCUCCCCC ACGCCGCCUCCCCUCCUCCCACCCACCACCGCCGCCGCCACCCCCGCUCCCCGC-CCCCG GAGCCCCGCGGACGCUACGCCGCGACGAGUAGGAGGGCCGCUGCGGUGAGC----CUUGA AGCCUAG--G-GCGC-GG-GCC--CGGG-U-GGA-GCCGCC-G--CAGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UGA----GAGAUG--GGCGAG--CGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUU-----G--CCCU--CGG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---GUGG-C-GGA--G----A--U----GG -G-C-------------------------------------------------------G CCGC-----------------------------------------------------GAG ----GCGUC-CAG-U-G--CGGUAACGC-G----A-CCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCCC-CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCCU G-G------A---AU-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GUGC-C--U--U-G--G-AA-A-GCG-UCGCG--------------------- ---------GU-UC-----------------------------C-GGC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGGCAU-GU-UGGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGUAUUGGCUG-UA--A-GG-GCUGGGUCGGUUG-GGC-------- ---------------------------------------------UGGGUGCAUGCCACC ACUGGAAGAGGCCCUGCAGCGCCCCCAUGCCCCAGGGAUGCCUGUCGUGGCCCUCCUCUG CCCCAACCCGCGUGCUGCUCG---------------------CUCCCUCCCCUGCCCCCU CUCUCCCUGUCCUCCCCCUC-UCUG----G-A-G-GU---G--GC-G-U-GU-GG-GGGC AGA-GGG---G-UGG-CGGU-GG-CCA-UAC-G-GCCCCGGUGGCAGGG-CAUG--AUCU CC--------------------------------------------------CGUGAGGG GGGGCUGGUGGUGGUGGUGACUCUGGACCCGAGCCGGGCCCUUCCCAUGGAUUGCCCCAG UUGU--GGCCGCCCAUG-GGGAGCCCAG-U--G-GGUGCUGG-CG-UGUCCUGUC-U-U- G-CUCCGU-GCUG-UCAU------GCG---UUU--CAG------CG-CGG------GCA- -G-GGAGUG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AUUGGGUGUCGGUGGGUGGUGGGCGGG GUGGUUCAUUCCCCCACCUCCCCCGCGGCCCCAU-CU--GUCU--CGU-G-UC-CCCC-C -CUCCGUGGAGG----UGGC---------------------------------------- ------------------------------------------------------------ --------------------------------GG--GCCA-CGG--GCU-GGUCCCC--- -ACC-AC-CGGGGC-G--GCGGUUC-------CGUGCAGCG-CCU---UGG-C-CGGUGC UUAG--CAGUCGACUU-AUAGAACUGGUGUGCACCAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCU-CG---G-G------------GGGUGU-U---- GCAAAGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-AUGAA-------------GAA A---------------UUCAA-UGAAGUAUGG-G-UAAAUGG-CAGAAGUAACUAUGGCU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAACUAAUGACGUGCAUGAAUGGAUGAAUG AG-A--UUCCCACUGUCCCUACCUACUUAC-UAUCCAGUGAAACCACAG--CCAAGGGAA UGGGGUUGGUGGAAUCACUGGGGAAAGAAGA-ACCUGUUGAGC-UUGACUGUAGUCUGGC AUGGUGAAGAGACAUGAGAGGUGUAGAAU-AAGUGGGAGGUC-C--C------------- ----------------CGGUGCCCCCUAUCCCU--------------------------- --------------GUGAGGGGGUGGGGUGGGGUCCUGU------------GGGC--UG- CCCA-UGGAAUA-CUACUACUAUGAUCAUUUUUUCACUGA-CCU-G--AUGA--GG-CAG GG-----------------------G-G-UG-AGCCC--------------CAAGA---- ---------GG-C-U--C-U-CC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CUUCUGGCG- ------------------------------------------------------------ --------------------------------------------CUAAG----------- ----U--GCCCAGA-UG---CA----------------UGCU------------------ ---G--G-C-----C-GGG--UGU-----------------UGAC-CC-AUUCC-GAGGA -CAG-UGCCAGGUGGGGAGUUUGACUGGGGCAGUACACCUGUCG-AACAGUAAU-ACAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCUUGUG-GAGCAG-AAGGACAAAA-G CUCGCUUGAUCG-UGAUUUUC-A---GUGCGAACACAGAC--UGAAAGCCGGGCUUUGAC G-AUCAUU-------------------------------------C-UGAC-GU--UU-- ----------------------------UUAAGCAGGAGCUGU-CAG--AGAAGUUACCA CGGGGA-UAACUGGCUCGUUGUGGCCAAGCGUUCAUAGGGAUGUUGCUUUUUGAUCCUUU GAUGUUGGUUCUUCCUAUCAUUGUGAAGUAGAAUUCACCAAGCAUUGGAUUGUUCACCCA CUAAUGGGGCAUGUGAGCUGGAUUUAGACCUUCGUGAGACAGGUUAGUUUUACCCUCCGU -GAUG--UGU-------------------------------------------------- ------GUUGUU-GCCAUGGUAA--UCCUGCUCAGCAUGAGAGGAACCACAGGUUCAGAC A------UGU----GCU-UGGUU-GAGG-AGCC-AA--UGGGGUGAAGCUA-CAGUCUGU --U-GGAUUGUGACUGAACGCCUC--U-AAGUCAGAAUCCCGCCCAAGA-GGAAGGA-UA CA--GCAGC---------------------------GC-CGUGGAGC----CU-U--G-- G--UUG-G-CCUU----------------------------------------------- ------------------------------------------------------------ ------------GG--CUGGCCUUGGCUA---------------------GCC-G--GUU -CC-C--CGC---C----C--------CCGC------UG---GUGGGCUG-CCU-C-GC- C--CUGGGU--GGGG-UGUGCCCC--ACCAU-----------------GUGCCAG--GAC --UGCGUCC----------GGUGC--AGAGUGCCCUUCUUCCUGGGAAGGGUGUGGCAGA AAAGGCGGC--------------------------------------------------- ---------CUC--CUUGCCUGUCAC-GCAACACACG-------------------UUCG UGGGGAACCUGGUG-----CU-AAACC---AUUG--G-UAGACGACCU-GC-UUCCGGGU UGGAGUUUCAUAAG-UAGCAGGGCAG--C-U--------------CCCUU--GCUGU--G -AUCUAU--U--GAAAGUCAG-CCCU----U-GA-CACA--AGGGU-UUGUC-------- -------- >Picea_glauca -------------GAAAUGACUCUCGGC-AACGGAUA-UCU-CGGCU-CUU-G--UCA-C GAUGAAGAACGUAGC-GAAAUGCGAUACUUA-GUGUGAAUUGCAGAAUC-CCG-U-GAAU CAUCGAGUUUUUGAACGCAAUU-UGCGCCCGAGGCCUC---------------------- ----------GGUCGAG------------------GGCA--------------------- -------------------------------------------------------CGU-C UGUCUGGGCGUCGCAU-------------------------------------------- ----AUGCGACCCCAGCUCA-GGUGAGAAC-ACUCGUUGAGUUUAAGCAUAUAAUUAAGU --GGAGGAAAAGAAACUUACAAGGAUUCCCCUA-UU-AAC-GACGAGUGAAGUGGGAAG- AGCCUAGCAUGAAAAUUGGGUG--------GCAGCGUCACCUAAAUUGUAGUUUGU---- ----------------------------AGAAGCAUC----------------------- ------------C------UUA--GCGAUG----GACCGGG------CCC-AAGUC-CCC UA-GA-------AGGGU------G-CGCC-UAAGAGGGUGAUAGCCCCAUUAGGUCGGG- ------------ACCCUGCCACAC-CAUGAGGCGUUGUCAGCGAGUUAGGUUGUUU---G GGAAUGUAGCCCUAAU-CGGGUGAAAAUUUUUGUCCAAGGCUAAAUAUGGG-UG-AGAGA CUGAUAGA-AAA-CAAGUACCGUGAGGGAAAUAUGAAA-AGGGA-UUUGAAAAGAG-AGU UAAAGAAUGCUUGAAAUUUUCGAGAGG---G-AAGCA-AGUGGAAGCUGGCGAUGUGUCU CGG--------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------U------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CAGAUGCAGAACAAAUCAAGUUGGUCCGC---CGCUGGACUCAAGGU GUGAACCAGCACAAGUCGU----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------UGCAUAGACACAAG-----CGC---------------- ----------------------------------------------AGGUGGAGUACUU- CCUAUUG-------GUUUU----------------CCAUUUUGGCGGUU----------- -GAGGAAUGA----------------------------AGCAU---GCGC---------- ---------------------------CCUUGGGGCAGGCCACUGUGCACCU-------- -GCACGCUCGUAGUGUUGGUU--------------------------------------- ------------------------------------------------------------ ----GGCGGGCU------------------------------------------------ ------------------------------------------------------------ ----------------------------UUCCAUUCAACCUUUCUUGAAACACGGACCAA GGAGUCUA-A----CAUGUGUGUGA---GUCGGU-GGG--U----------UUGUAA--- --------ACCU-G-C-GAGGUGUAAUGAAG-CUUACG---------------------- ---------------------------------------------------------GGA GAGAACCCCUCUC----------------------------------------------- ----------------------------CAUG------GGGUGCAUUUCU----GACUGA CC-U-UGA--G----------------------------CUUGU---------------- --AC--GAAGG-GUUCAAGU-GC-GAGCACACCUGUUGG-GACUCGAAAGAUG-GUGAAC UAUGCCUGAGUAGGGUGAAGCCAGA-GGAAACU-CUGGUGGAUUCCCGU--AGCAAUACU -GACGUGAAAAUCGUUCAUUUGACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAUCUGGUUUCCUCUGAAGUUUCCCUCAGGAUAGUUGGAGC-U--------------- ------------------------------------------------------------ ---CACG-UGCG-------------AGUUUUAUCGGGUAAAGCAAAUGAUUAGAGGCA-U UGG-U-GGU-G--UAA--CGCCCU-UGACCUAUUCUCAAACUUUAAAUAGGUA-AG--AC AAU-----GCAGAU---GC-UCCAUU-------------------GAGC-C-G----U-- -G-C-C--------------------------------------------------AUGA -AAU---GG-A--GA--G-CUCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UA -GCGAUG-CAGGA----UGA--ACCGAAAUUUG--AAUUACG--GUGCC--AAACUG--C A-C-GC-U-AAC--CUAGA-UCCC--ACA-AAGGGUGUUGGUUGAUUAAGAUAGCAGAAU GAUGGUCAUGG-AAGUCAAAAU-CUGCUAAGGGGUGUGUAACAAAUCACCUGCC-----G AAUCAUCUAGCCCCAAAAAUG-GAUGGCGUUG-A-AGCGC---ACA--------ACC--U AUA-CUCGACC--AUU---G--G---AGA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AAUUGCCAG-------------------------- -------------------------------GCUU-U-G-A-UG-A--GUAUGA----GG A----CAUA-GGGG-UC-------------------AU-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GAGA AACAUUG--G-GCAU-GA-GCC--UGGG-U-GGA-CCGAUC-C--CCGAUGCAGAUCU-U GGUGG-UAGUA-GAA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-AAACUGGAG-AAAGGUUCCA-UGUGAACAACACUUGGA CAUGGG------------UUAGUCGA-UC-C-UUA----GAGAUG--GGGAAG--CCCU- ---------------------------G-UAU--CAAGG---GUG-----CA-------- ---------------------------CUCU----------------------------- -----------G--------CAC------GAACAUC---GA-AA-GGGA-AUU-GGG--U UAA----UAUU-CUC----GAACC---GGAA-CAUGG-----------CGACAG------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------A--CGAAAAUGU-----UA-GGAAAU-CCAU-A-GAC-GUCG-U CGGG----GGCCC-CG-GG-A-AGAG------UUAUCUU-------UUC-UUU---UU-- -A----U-AGC----UUGC-C-------------------------------CA--CCCU G-A------A---AU-C--A--G-----C--GCA-A-CCA-GAGAU-AG--GG----U-- -C-CA--ACAG-C--U--G-G--A-AG-A-GAA-UCGUA-CA------------------ ------------UC-----------------------------U-UGU-GGU--GU---C UG-GUGUGCC----CU-C--G-G-UGGCCCUUGAAA-A-UUUGGAGGAC--CGAGUAC-- ------------------------------------------------------------ -C--AUCC-AUG--CC-C-AGUCUUACUCAUAACCACAUUAGGUAUCCA-AGG-UGAAAA -G-ACUCUGG-UC-AA-UAGA-ACAAUGUA-GGUAAGGGAAGAUGGAAAAA-CGGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-UG--A-GG-GCUAGGC-CU-AG-AGG-----UCU GCA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------UCCUCAACC---------------C-GU------G--G---GCUGU-UGA- -UA-G-------------U---------C-U----------------------------- ------------------------------------------------------------ -----------------------------------------------------------U CCCAA------------------------GCUGCUAUCGUGG-UGAGGGCGGGAA----- G-UC-----AUGU-----------G-----UUGAUUGG-----GCUACUG------ACA- -U-AGAAUGUC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CUCUCGCG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------GGGGCUUUUC-----------------CCU---------AGGAAA UGAA--CAG-U-CGAC-UCAAAACUGGUACAAACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUUGUGA-UGGUCC--CU---G-C------------AGAUGC-UG-AC GCAAUGUG-AUUUCUGCCUAGUUCUC-UAAAUUUCAAA-UUGAA-------------GAA A---------------UUUAA-CCAAGCGCGG-G-UAAACGU-CGGAAGUAACUAUGACU GUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGAUGUGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUAUCCCUA-UA-UAC-UAUCUAGCGAAACCACAA--CCAAGGGAA UGGGCUUGGCAGAAUCAGCGGGGACAGAAGA-CCCUAUUGAGC-UUGACUCUAGUCUGAC UUUGUGAAAUGAAUUGAGAGGUGUAGAAU-AAGUGGAAGUCGUU---------------- ------------------------------------------------------------ ----------------------------------UUCGG------------------UG- CAAG-UGAAAUA-CCACUACUUUUAAUGUUAUUUUACUUA-UUC---UGUGC--GG--UG GA-----------------------G-A-CG-GGGCA----------------------- -------UUGC-C----CCU---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AUUUUUUUCC- ------------------------------------------------------------ --------------------------------------------UUAA------------ ----G--------------ACAC--AU-----------UUUGA----------------- --------------C-GAG---------------------UUGAU-CC-GGGUG-AAAGA -UAG-UGUCAGCUGGGGAGUUUGGCUAGGGCAACACCUAUGUUA-AAAGAUAAU-GCGAG UGUCCUAAAAUGAGCUCAAGGAGAACAAAAAUCUCGUGUG-GAACAA-AAGGGUAAAA-G CUCAUUUGCUUU-UGAUUUUC-A---GUACGAAUACAAACCGUGAAAGCGUGGCCU-AUC G-AUCCUUUA-------------------------GA-AU-------UUUA-GAA-UU-- ----------------------------UGAAGCUAGAGAUGU-CAG--AAAAUUUACCA CAGGGA-UAACUAGCUUAUGGUAGCCAAGCGUUCAUAGCGACGUUUCUUUUUUAUCCUUC GAUGUUGGCUCUUCCUAUCAUUGUGAAGCAAAAUUCACCAAGUGUUGGAUUGUUCACCCA CCAAUAGGGAACGUGAGUUGGGUUUAGACCGUCAUGAGACAGGUUAGUUUUACCCUACUG --AUGA------------------------------------------------------ ----ACCAUGCC-ACAAUAGUAA--UUCAACUUAGUACGAGAGGAACCGUUGAUUCAGAC AAU-UGGUCAUCGCGCU-UGGUU-GAAA-AGCC-AA--UGGCGCAAAGCUA-CCAUGUGU --C-AGAUUAUGAAUCAAUGCCUC--U-CAGUCAAAAUCC------ACG-CUA------- -GAAGCGAU---------------------------GC-UUGUCACUC---CU------- ---CGACUAUAUC----------------------------------------------- ------------------------------------------------------------ ----------------UUGACCUGCAGUA---------------------GG--GGUGUC ACUUCG---------------------------------------------------GAA C--CCCCAG--GGGCUCGUGUCACUUGCGAA-UCUCAGCCAGGAAGCAUCUCGGU----- -------------------CGAGGCAUA-------------------------------- ------------------------------------------------------------ --------------UUUGAAGUUCAAUUUCA----------------------------- AAUGGUUGUUGAGAA-------GAAUC---CUUU--G-UAGAUGAAUU-AA-ACACAGGA UGGGGUAUUAUAAG-UGGCAGAGUGG--C-C--------------UUACU--UCCAC--G -AUCCAC--U--GAGAUUCAC-CCCUU-CAUCACCUCGA--------UUCAG-------- -------- >Plasmodium_falciparum -------------UAGCACAGUCUUAAC-GAUGGAUG-UCU-UGGUU-CCU-A--CAG-C GAUGAAGGCCGCAGC-AAAAUGCGAUACGCA-AUGAAAAUUGCAGUGAC-U-G-U-GAAU CAUCAGAAUGCUGAAUGUAAAC-UACACCAAUUCCUUCG--------------------- -------G-GGAAUAGU------------------GGUA--------------------- -------------------------------------------------------CUC-C UACAGAAAA--------------------------------------------------- ---UGUUUGAUUUGAUGUUA-GGAGGGCAA-AUCCGCCGAAUUUAAGCAUAUAAUUAAGC --GGAAGAAAAGAAAAUAACUAUGAUUCCUUUA-GU-AAC-GGCGAGUGAACAAGGACCA GCUCAAACGGUUAAUCCUUCGUUUGGUGCAAACCUUUCGACGGAAUUGUCGUUGAA---- -----------------------------UUAUUCC------------------------ ------------A------UGA--AUGCCU--UUAAUUUGA------GCA-AAGUG-AGC AG-GA-------AUGCU------U-CCCC-AUAGAGGGUGAAAGGCCCAUAGUUCUUUU- -UAAUUU-----------AUUCAU-UGGAAU-UUUUCAUGCCGAGUCGUGUUCUUU---G AGAUUGGAGCACUAAUACGUGUGAUACAUUUCACAUAAAGCUAAAUAUGUG-UA-GGAGA CCGAUAGC-AAA-CAAGUACCGUGAGGGAAAGAUGAAAUAGUAC-UCAGGAAUGAGCAAU UAAAUAGUACCUGAAAUCGUUAAGAUG---G-AACGG-AUUAAGAGAGAAAACAAG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------UA AAGAGGG----------------------------------------------------- --------------------------------------GA-AUUUUUA--------AUUU UUUUUGUUAUAAUUCUC--UUCUUUAUUAAAAGAAA-----C-A-UCAGUGAUUAAUUUA AUUUCAAUAA-AG-CAAUCCCC------UGAAAUUCAAAAUUUC--UUUUAAUUUUCUU- UUCACU---------UUCU-CCCCGCA--CUA--------AUGUG-----GGGAAAACU- ---------G-GCUUUAUUUCUUCA--------AUU--A--------------------- ----------UUUUUUUU---------GCUG--------------------------AGG AAUUUUAAAAUUAUUUGAAUU-UUUCUUCUU----AUAAUUUAAGUUGUUUCU------- -------AUAUAGUA-CU--U--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UCUUAACCCACUCGUCUUGAAACACGGACCAA GGAGUCUA-G----CAAAUGUGCAA---GUGUAU-AUG--A-U-U--CUUUAAACAUUUC UCUU--UUUAAU-A-U-A-CGCAUAAUUAAU-GUAAU---------AUGU---------- -------UUCU-------------------UU-AU----------------------UGU AGA--UUU--G-U-G---U--G----------GUGUUUAAU-UUUU--------A--U-- U--A--A----AU----C--C----C--C--A--C---UUU--GCAUACA-----UCCGG UA-A------G----CA----------------------AUUA----------------- --UG---C-UU-UAUUGAGUA-C-GAGCAUAUUUGGUAG-GACCCGAGAGGCU-UUGAAC UAAGCGUGAUGAGAUUGAAGUCAGA-CGAAAGU-CUGAUGGAGGAUCGA--GUUGAUACU -GACGUGCAAAUCGUUCAUUUCAAUCACGUUUAGGGGCGAAAGACUAAUCGAAAAGCC-U AUUAGCUGGUUAUUUUCGAAAGAUCUCUCAGGAUCGCUGGAGU-U--------------- -------------------------------G-----------------AAUUA--AUA- ----UA--------------------AUUUUACCAGGUAGAGAUAAUGAUUAGAGGAA-U CA--G-GGA-A--AUCG-UUUUCCUUGACCUAUUCUCAAACUCCCAAUAGGUA-AA--AA ----GGG-CGAAAU---AACUCAACUU----------------G-UAUU-U-C---AC-- -U-CAU--------------------------------------------------AUUA AAUAA---A-A--UA--A-CUCCA-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-AGGGA----UGC--UCCUAACGCUU--GGAUAAG--GUGCC--UAAAUA--U U-C-GC-U-CAU--G-AGA-UCCC--AUA-AAAGGUGUUGGUUCAUAAUGACAGUAGGAC GGUGGUCAUGG-AAGUCGAAAU-CCGCUAAGGAGUGUGUAACAACUCACCUACC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUA-A-AGCGG---AUU--------ACC--G AUA-CCAAGCC--AUA---A--A----AA-G------------AACAG-A---------- ----AAAAA--------------------------------------------------- ------------------------------------------------------------ -------------------------UUUAUUU---------------------------- -----UUUUU-----UUAGAAU---------CUUU-U-U-A-UG-A--GUAGAA----AA ---U-CGUG-GGGU-UU-------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------UUGA AGCGAAA--U-ACGU-GA-GUU--UUCG-U-GGA-ACAUCUCC--CUAGUGCAGAUCU-U GGUGG-AAGUA-GCA-A--CU-AUUCAAAA------------------UGAGAAC----- ----------UUUGAA-GACU-GAAGUGGAG-AAGGGUUUCU-UGUCAACUGUGAUUGAA CAAGAG------------UUAGCCGC-UC-C-UAA----GGGAUA--GCUGAA--AAGU- ---------------------------G-U-U--UAAAA---GGG-GGU----------- ---------------------------UCC------------------------------ --------------UU-C--C-C-C------GUCUC---AA-AA-GGGA-AAC-AGG--U UGA----UAUU-CCU----GUGCCAA-UAGU--AU-U-A-U----G----A--G------ -----------------------------------------------------------U UU---------------------------------------------------------- -------CU-U--AG-A--UGGUAACAUAUAUAUAAAUGAAC-UCCU-U-UAC-AUAG-G CUUU----ACACU-CG-GG-G-UGCG------UUUUCUU-------UGC-ACU---UU-- -A------CCU------UU--------A------U--------A---ACAA--A--CCUU G-G------A---AU-C--A--A-----U--UUA-C-UUG-GAGAA-GA--GG----U-- -U-CG--UU-G-A--A-CUCAAUUCAA-A-AAA-UUUCU-UGAACGGGGUUUUCGGAUUC AGUUCAUUUUAUUUUUUGUUUUGUAGCAAUAGUAAUUCGUUUUUAUGA-AUU--AU---C CG-AAGUGGU----AA-G--G-A-CUAUCCUUGAAA-A-AAGGAGGGAA--CGGCUUUG- ------UAA---ACUUGGUUUCUUCUGAUUCCAUUUUGCUUUGCUAUACUC----UUA-- -A--UA-C-UUG--UA-U-GAGCGUACCAACAACCGCAUCAGGUCUCCA-AGG-UUAACA -G-CCUCUGG-UUAAA-UAGA-AAAAAGUA-GGUAAGGGAAGUCGGCAAAAAUAGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-UG--A-GG-ACAUUAG-AA-AA-GAG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AAGAAAA---A--A-A----G-A-G-GG---U--C--G-A-A--AA-UAA- -A--A-U---U-GCA-G-U--CU--UA-U-U-U-GCU-UUUC------------------ ------------------------------------------------------------ -----------------------------------------------------------U UU-C-----------------------G-A--U-UU-GCUUG-UA-A----UC-U-G-C- U-UU-UUC-UUUU-UC-U------U-C---U-U--U-C-------U-U-U------UUU- -U-CUC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------CCCCUCUUUUCGCCUUCACUUUAU---------------------------- ---------------UGUA----------------------------------------- ------------------------------------------------------------ -----------------------------------------------------AU----- -UUU--AUU-A--C-UUUA---------------------A-UUU---GAU-A-CC---- UAUA--AUG-U-UAAC-UCAGAACUGAAACGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAUAGCAUUGUGAAAAGCCA--CA---A-C------------UGGUAU-UA-AC ACAAUGUG-AUUUCUGCCCAGUGCUU-UGAAUGUCAAC-UUGAU-------------GAA A---------------UUCAA-UCAAGCGCAG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUA-CU-UGC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAAAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUUACUCUAGUCUGGC UUUGUGAAACGACUUAAGAGGUGUAGCAU-AAGUGGGAG-UA-G--A------AAC-UG- ------------------------------------------------------------ ---------------------------------AAAUA------U--GUU-UUUA--CG- ACAG-UGAAAUA-CCACUACUUUUAAAGUUGUUUUACUUA-UCC-AUUUAUA--GG--GA AA-----------------UAUAUUA-U--G-CUUUAUCC-----------UUCG----- -GG--A---A--G-G--C-A--UUCUGAUAUUAUU------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------UGAAUUUUUAA ------------------------------------------------------------ ------------------------------------------------------------ ----G--AAA---C--U---UGU---------------UUC------------------- U--U--A-------U-UUU--UCUCC----------------CAU-UU-C-UAU-GGAGA -CAU-AGCCAGGUGGGGAGUUUGACUGGGGCGGUACAUCUGUUA-AAUAUUAAC-GCAGA UGUCCAAAGACAAGCUCAAAGAGAACAGAAAUCUCUUGUA-GACUAA-AAGGGGAAAA-G CUUGUUUGAUUU-CUAUUUUC-A---GAACAAGUAGAAAACGUGAAAGCGUGGCCU-AUC G-AUCCUUUA-------------------------U--A------UUUGCA-AAA-UG-A CGUAAAUUACUUACUACUG---------UGCAUAUAGAGGUGU-CUG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCUGCCAAGCGCUCCUAGCGACGUAGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGGGACGCAGAAGUCUCAAAGUGUCGGAUUGUUCACCCG CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGAAU-U------------------------------UUAUUAUAUUUUUUAUAUAU ACAUAUAGUAUU-GUGACAGUAA--UCCAACUUGGUACGAGAGGAUUAGUUGGUUCAGAC AAU-UGGUACA-GCAAU-UGGUU-GACA-AACC-AG--UGUUGCGAACGUAA--GUCUGU --U-GGAUAAUGGCUGAACGCCUC--UUAAGCCAGAAACC------AUG-CUG--AU--- -UAAACAAU---------------------------AC--UAUUUC----GUU-C--U-- U--UUU-U-GUUUC---------------------------------------------- ------------------------------------------------------------ ------------CU--UUUUU------------------------------A--C--U-- --------------------------GCUAA----------------------------- U--GU-----------------AAAAGA-GAAA-UUAUAUAU------G---------UA ---CCUU------UU--UU-----------------U---------------G------- GUACAUAA---A----------UAA-----UCCUAUCAC----CUUUUUCGUGAGCUGUG AGCUGUGAGCUAGGCAAUAGUUCUUUA--------------------------------A CAACAAAAA-AGAA----UUG-CACA----AACU--G-UAGACGACUU-UU---UUGCCU CAGGGUGCUGUAAA-CAUGAAAGUAA--A-CU-------------UUGU---UUUAC--G -AUCUGU--U--GAGGCUUAU-C-CC----UAGU-GGUA-A--AGU-GU--UU------- -------- >Protopterus_aethiopicus ----------------NNNNNNNNNNNN-NNNNNNNN-NNN-NNNNN-NNN-N--NNN-N NNNNNNNNNNNNNNN-NNNNNNNNNNNNNNN-NNNNNNNNNNNNNNN-------N-NNNN NNNNNNNNNNNNNNNNNNNNNN-NNNNNNNNNNNNNNNN--------------------- -----------NNNNNN------------------NNNN--------------------- -------------------------------------------------------NNN-N NNNNNNNNNNNNNNN--------------------------------------------- ------NNNNNNNNNNNNNN-NNNNNNNNN-NNNNNNNNNNNNNNNNNNNNNNNNNNNNN --NGNGGAAAAUAAACUAACCAGGAUUCCCUCU-GU-AAU-GGUGAGUGAAGAGGGAAU- AGCCCAGCACCAAAUCCCUGC-CUGGGCG-AUGGGUGAAGGGGAAAUGUGGCAUAU---- ----------------------------GGAAGUUUG----------------------- ------------UCUCCCCGGU--GCCGCC-----CAGGGG------CCC-AAGACCUUG UG-A--------UCGAGGCU---C-AGCCCGCGGAUGGUGCGAGGCCGGUGGCGGCCCC- -UG-GCAAG---------U----C-AGGGACAGGUCUCCCCGGAGUCGGGUUGUUU---G UGAACGCAGCCCAAAG-UGGGUGGUAAACUCCAUCUAAGGCUAAACACUGG-CA-UGAGA CCGAUAGC-GGA-CAAAUACCAUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAAGUGUUCAGAGG---U-AAAUG-GGUGGGGUCUGCGUGGUCCAUC CGG----AGGAUUCAAC-AUGGCGGGU---GCGC--UGGCCGGACGGAUGA--------- ------------------------------------------------------------ ------------------GGGGGUUCCCCUCCACAUCCGGGGUUG--------------- ------------------------------------------------------------ -GGGGGACUGUC-CCCUAGCAUG---CUGGCCGCCGUCAGGUGUAUUUCCUCUGU-GGUC GUGCACCGC-ANNCAGCUCCGGGUCAGCUGGGAAGGCCA-------UGC------GGAAG GUGGCUC----------------------------------------------------- ------------------------------------------------------------ ---------CCCUCAUCGU----------------------------------------- ---------------------------------------------------------AGG AGAGUGUUACAGCCUG-----------UAGCAUCAG-----C-C-CUCG----------- -----------CC-GUGCCCGGGGUCAUGGG-----A-GAUGACCACUGCCGCACCCAC- UCCCGC--------CCUCU---------------------CGGUGGG------------- ----GGCUGG-GGGCUA------------------------------------------- ---------------------------------------------------------CCG -GUGGGACUGUU------------------------------------------------ ----------------------------------------------------------GA CUGGGCUGGACUGCCCUCAAU-GCGGCCUGACUGCAUCCUGCACCAUGCCGGUGGGCUCA CC------------------------------------------------------UCGG GUUCCCGGGGU----------GAUGGUGACCCACCCGUCCCAUCUUGAAACACGGACCAA GGAGUCUA-A----UAGGUGCGUGA---GUCUGA-GGG--U----------GGGCAGG-- --------AGAC-U-CCACGGCACAAUAAAA-GUGAGA--------GCUGG-U------- -------GCAU-----------------GCCG-GC-UGA------------------GGU GGGAUCCCCCGCC-CUG-C----------------------------------------- --------------------A----C--G--G--G---GGGUGCACCGCC----AGCCCG UC-U-C----A---CCC----------------------GUCCC---------------- --GU--CUGGGAGUUGGAGC-AU-GAGCGCACCUGGUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGGUGAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCAGUCCU -GACAUGCAAAUCAGUCAUCCGACCUGAGUAUUGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCACCAAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- -------------------------------CG------------------GUG--GA-- ---CGC-------------------AGUUAUAUCUGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-G-C-G--AAA--CAAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGACUC---GC-UGGCUU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GUGG -AAU----G-C--GA--G-CACCC-AGU-GAG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUCGCCGG-CGCUGGG--------AGCCGAGG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGGCUAGG------------------------ ---------------------C--------------C-GCGCCG-A--GUAGGA----GG ---GCCGCC-GCGG-UGGCA---------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CUGA AGCCCAG--G-GCGA-GG-GCC--CGGG-U-GGA-GCCACC-G--CGGGUGCAGAUCU-U GGUGG-UAGUA-ACA-A--AU-AUUCAC-A------------------CGAGAGC----- ----------UAUGUA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUUGG-UC-C-UGA----GAGAUA--GGU---------- ----------------------------------------------GA------------ ------------------GGCGAUGGCCUCC----------------------------- ---AUC-----A-UCC-U--UGG-C------UGAUU---GA-AA-GGGA-GUC-GGG--U GCA----GAUC--------------C-AGG---GUAG-C-AUU--G-------------- -A-C------------------------------------------------------UG UUGC--------------------------CU-------------------------CAC ---AUCAUC-CAG-U-G--UGGUGAUGC-A----A-AUGAUC-CCAC-A-GGA-GCUG-G CUGG----GGCCC-AU-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -A------AAG------GA-C------A------G--------G---G----CG--CCCU G-G------A---AU-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GCGC-C--C--U-G--G-AA-A-GCG-UCGCG--------------------- ---------GU-UC-----------------------------C-GGC-GGC--GU---C AG-GUGAGCU----CU-C--G-C-CGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAG------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UAGA-ACAAUGUA-GGUAAGGGAAGUCGACAAGC-CAGAUCCG UAACUUUGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGUCAG-UU-GGG-------- ------------------------------------------------------------ --------------------------------------CUUGGUCAUGAAGCUGGGCUGG GUGCAUGCCACAGCUGGACAAAGCGCCAGGGUUGACCCCAGGGUCGUCACCCUCUCGCCU CACUCCCCCCACCCGGCG---------------G-GG---CCUGG-G------GGAUGG- -CA-GCAACUG-UGG-----------------------------------------AUCA CC---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------CG------------ G----------------------------------CUG------UGGCGA------GCAC UG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AUCCUGA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----CC-----------ACAGUCCCG---------------CAG---UGU-C-UGGCAG CUAG--CAG-C-UGAC-UUAGAACUGGUGCAGACUGGGGGAAUCCGA-----CUGUUUAA UU-----AAAGCAUUGCGA-AGGCCG--AG---A-C------------AGGUGU-UG-AU AAGAUGUG-AUUUCUGCCCAGUGCAC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGACGUACGG-G-UAAAUGG-CGGGAGUAAUUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAAUGGGGAAAGAAGA-CCCUGUUGAGU-UUG------------- ---GUGAAGAGACAUGAGAGGUGUAGAAU-AAGUGGGAGGCCUCAGC------------- ------------------------------------------------------------ ---------------------------------------------------------UG- CUGG-UGAACUA-CCACUACUCUUAUCGUUUUUUCACUUA-CCC-G--GUGA--GG--CA GG---------------------GGG-G-CG-AGCCC--------------CACCG---- --------GGG-C-U--CUC-GC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCUGGCU- ------------------------------------------------------------ --------------------------------------------CCAAG---------CG -------------CCCG---------------------GGCG------------------ --------U-----CCGGG--CGC------------------GAC-CC-GCUCC-GGGGA -CAG-UGUCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AAGAGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUAUGAAUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--GC-----U-UUUU-GGG-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-UGU-------------------------------------------------- ------GUUGUU-GCGAUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGUGCGAAGCUA-CCAUCUGU --G-GGAUUAUGANNNNNNNNNNN--N-NNNNNNNNNNNN------NNN----------- ------------------------------------NN--NNNNNNN----NN-N--N-- N--NNN-N-NNNN----------------------------------------------- ------------------------------------------------------------ ------------NN--NNNNNNNNNNNNN------------------------------- ------------------------------------------------------------ ---NNNNNNNNNNNN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------NNNNNN------------------------ ----NNNNN-NNNN-----NN-NNNN----NNNN--N-NNNNNNNNNN-NN-NNNNNNNN NNNNNNNNNNNNNN-NNNNNNNNNNN--N-N--------------NNNNN--NNNNN--N -NNNNNN--N--NNNNNNNNN-N-NN----NNNN-NNNN-N--NNN-NN--NNNN-NNNN ---NNNNN >Rattus_norvegicus -----------------CGACUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-AUGUGAAUUGCAGGACA-CA--U-UGAU CAUCGACACUUCGAACGCACU--UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCUA--------------------- -------------------------------------------------------CGC-C UGUCUGAGCGUCGCU--------------------------------------------- -----CGCGACCUCAGAUCA-GACGUGGCG-ACCCGCUGAAUUUAAGCAUAUUAGUCAGC --GGAGGAAAAGAAACUAACCAGGAUUCCCUCA-GU-AAC-GGCGAGUGAACAGGGAAG- AGCCCAGCGCCGAAUCCCCGC--CGCGCG-CC-GCGGCGCGGGAAAUGUGGCGUAC---- ----------------------------GGAAGACCC----------------------- ------------ACUCCCCGGC--GCCGCU--CGUGGGGGG------CCC-AAGUCCUUC UG-A--------UCGAGGCC---C-AGCCCGUGGACGGUGUGAGGCCGGUAGCGGCC--C -CG-GCGCG---------C----C-GGGCCCGGGUCUUCCCGGAGUCGGGUUGCUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGC-CAA-CAAGUACCGUAAGGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGUCCGCGCAGUCCGCC CGG----AGGAUUCAAC-CCGGCGGCGCGC-GCC--GGC--CGGCCGGUGG--UCCCGGC GGAUCUUUCCCGCUCCCCGUUCCUCCCGACCCCUCCACCCGCGCGUCUCUCUCCCCCCUC CCCGCGUCCCGCCGUCGCCGUCCCCGCUCCUCCC-UCCGGGGGGGUGUCGGCGGGCGCUC CGGCGGCGGGCGCGGGGUGUGGUGGGGGCGCGCGGGCGGGGCCGGGGGUGGGGU---CGG CGGGGGACCGCC--CCCGGUCGGCGACCGGCCGCCGCCGGGCGCACUUCCACCGU-GGCG GUGCGCCGCGAC-CGGCUCCGGGACGGCUGGGAAGGCCC-------GGCGG----GGAAG GUGGCUCGGGGGGGGCGGC----------------------------------------- -----G-----------------------------UCACC-C-GUGG------GCGCCG- ------------------------------------------------------------ --------------------------------------GA-CCACCCC--------GCCC CGAGUGUUACAGCCCC----------CCGGCAGCAG-----C-G-CUCG----------- -----------CC-GAAUCCCGGGGCCGAGGGAGCCG-GAUACCCGUCGCCGCGCUCUC- CCCCCGG-------CCUCU-CCCCUCCCGCCCCUCC----CCGUGGGGUGGCGGAAAGG- ---------G-GGGCGG------------------------------------------- ---------U-------C---------GCGGGGGCCGGGCCGCCCCU-CCC------ACG -GCGCGACCGCUCUCCCACC--CCCC---------GUCGCCUCCGUCGUCC--------- -----------------CUCUCGGGGGUCCG-------------GGGG----CCCGGGGG GCGGGGCGGACUGUCCCCAGU-GCGCCCCGG------GCGUCGUCGCGCCGUCGGGCCCG GGGGGGCCGUCGUCACGCGCUCUCCCUCCCCUU-CUCGGGGUGGGGGGGAGCGAAGCCGA GCGCACGGGGUCGGCGGCGAUGUCGGCUACCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CGCGUGCGCGA---GUCAG--GGG--C-U-C------GUCCGAA-- --------AGCC-G-CCGUGGCGCAAUGAAG-GUGAAG-------GGCCCC-G------- ------UUCCCG--------------G-GGGC-CC-CGA------------------GGU GGGAUCCCGAGGC-C---U--C----------U-C------CAGUCC------------- --------------------G----C--C--G--A---GGGCGCACCACC----GGCCCG UC-U-C----G---CCC----------------------GCCGC-------------G-- --CC--G-GGGAGGUGGAGC-AC-GAGCGUACGCGUUAG-GACCCGAAAGAUG-GUGAAC UAUGCUUGGGCAGGGCGAAG-CAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- ---------------------------CUCGCA------------A-----CGC--GUU- ---CGC-------UCGACAACCCGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--CGAUCU-CAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCGU-------------------GGAG-C-C----G-- -G-G-C--------------------------------------------------GU-G -GAU----G-C--GA--G-UGCCU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC--CGAUGC--C GAC-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUC---G--C---CGG-C-----------AGU-CGGA---------- ----ACGGGAC----GGGA----------------------------------------- ------------------------------------------------------------ ----------------------------GCG-------------------------GC-C GCGGGCGCGC-----GA----C---CCCGGGGGCC-G-G-G-CG-G-CGUCGGC-UUCGG CCGGCCGCCGCCCG-UCCACCCCCGGGGCUCCCCCCGCGGCGUCGGG------------- ---------------------------------------------------CCC------ ------CGCGGAGCCUACGCCGCGACGAGUAGGAGGGCCGCUGCGGUGAGC----CUUGA AGCCUAG--G-GCGC-GG-GCC--CGGG-U-GGA-GCCGCC-G--CAGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UGA----GAGAUG--GGCGAG--UGCC- ---------------------------G-U-U-CCGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCC----------------------------- ---GUU-----G-CCC-U--CAG-C------CGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAAUC-C-GGA---GUGG-C-GGA--G----A--U----GG -G-C-------------------------------------------------------G CCGC-----------------------------------------------------GAG ---GCGUCC-AGU-G-C--CGGUAACGC-G----A-CCGAUC-CCGG-A-GAA-GCCG-G CGGG----AGCC--CG-GG-G-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C------A------G--------G---G----CG--CCUU G-G------A---AU-G--G--G-----U--UCGCC-CCG--AGAG-AG--GG----G-- -C-CC--GUGC-C--U--U-G--G-AA-A-GCG-UCGCA-G------------------- ---------UU-CC-----------------------------G--GC-GGC--GU---C CG-GUGAGCU----CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ ----UCUC-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAAC- -G-CCUCUGGCAU-GU-UGGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGC-CGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGU-CGGUC-GGG-----CUG GGGCGCGAAGGCGGGGCUGGGCGCGCGCCGCGGCUGGACGAGGCGCCGCCGCCCCCCUCC CACGUCCGGGGAGACCCCCUCCUUUCCGCCCGGGCCCGCCCUCCCCUCUCCCCGCGGGGC CCCGCCGUCCCCCGCGUCGUC---------------------GCCGUGGUCCCCUCCUCC CUCCCUUCUUCCCCGUCC-GC-GGG----G-G-G-GA---C--G--GGGCGG-GUGCGG- -GG-GGG---C-GCG-C-G--CGCGCG-C-G-G-CCC-AGGGGCGGC-GGGUCC--AACC CC---------------------------------------------------------- -----GCGCGGGCCGGAGCGGGGGGAACCCGCGGGCCCCCGGUGGGGGGGGGCCCGGACA CC-C--GGGGGGGA-CC-GGCGGCG--GCG--GCGACUCUGGACG-CG---AGCC-G-G- G-CCCUUC-CCGU-GGAU------C-GCCCCAG--CUG------CGGCGG------GCG- -U-CGCGG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CC GCUCCCGGGGAGCCCGGCGGGUCGCCCGGCGGGGUUUUCCUCCGGCCUCGUCCUCCCCCU UCCCCCUCCGCGGGGUCGGGGGUUCCCGGGGUUC-GG--GGUU--C-U-C-CU-CCGC-G -CGGCGG--UUC--CCCCGC---------------------------------------- ------------------------------------------------------------ --------------------------------CGGGUGCG-CCC--CCC-GGG-CGC--- -GGUUUC-CCG--C-G--GCCGCCC---------------G-CCU---CGG-C-CGGCGC CUAG--CAG-C-CGAC-UUAGAACUGGUGCGGACUAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCCG-CG---G-C------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-AGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCCAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGGC ACGGUGAAGAGACAUGAGAGGUGUAGAAU-AAGUGGGAGGCC-C--C------------- ------CGGCGCCCCCCCGUUCCCCGCGAGGGG--------------------------- --------------UCGGGGCGGGGUCCGCCGGCCUCGC------------GGGC--CG- CCGG-UGAAAUA-CCACUACUCUCAUCGUUUUUUCACUGA-CCC-G--GUGA--GG--CG GG---------------------GGG-G-CG-AGCCC--------------CGAG----- --------GGG-C-U--CUC-GC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------UUCUGGCG- ------------------------------------------------------------ --------------------------------------------CCGAA----------- ----C--GCG---UCCG---C----------------GCGCG------------------ ---C--G-G-----GCGGG--CGC------------------GAC-CC-GCUCC-GGGGA -CAG-UGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AACGGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUACGAAUACAGACCGUGAAAGCGGGGCCU-CAC G-AUCCUUCU-------------------------G--AC-----CUUUUG-G-G-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-UGU-------------------------------------------------- ------GUUGUU-GCCAUGGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGGGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------GCC-CAAGCGG--- -A--ACGAU---------------------------AC--GGCAGCG----CC-G--A-- A--GGA-G-CCUC----------------------------------------------- ------------------------------------------------------------ ------------GG--UUGGCCCCGGAUA---------------------GC-CG--G-- -CU-CC--------------------CCGU---------------------C---C-G-- U--CCCCGU--CCGG-CGGGUCCCCGCCUCG-----------------UCGCCCC--C-C C-GGG--------------UGCGGG------G----C--GG--GU-C-CCCC--GC--CG GGCGUCGGGACCGGG-GUCCGGUGC-GGAG--AGCCAUUC-GUCCCGG-GAAACGG-GGU -GC-GGCCGGAAAGGGGGCCGCCCUC-UCGCCCGUCAC--GCUU----AA-CGCA-C-G- ---UUCGUGUGG-AACU--U--GGCGCUAAACCAUUCGUAGACGACCU-GC-UUCUGGGU CGGGGUUUCGUACG-UAGCAGAGCAG--C-U--------------CCCUC--GCUGC--G -AUCUAU--U--GAAAGUCAG-C-CC----UCGA-CACA-A--GGG-UU-UGU------- -------- >Saccharomyces_cerevisiae -----------------AAACUUUCAAC-AACGGAUC-UCU-UGGUU-CUC-G--CAU-C GAUGAAGAACGCAGC-GAAAUGCGAUACGUA-AUGUGAAUUGCAGAAUU-CCG-U-GAAU CAUCGAAUCUUUGAACGCACAU-UGCGCCCCUUGGUAUU--------------------- -----------CCAGGG------------------GGCA--------------------- -------------------------------------------------------UGC-C UGUUUGAGCGUCAUU--------------------------------------------- ---UGUUUGACCUCAAAUCA-GGUAGGAGU-ACCCGCUGAACUUAAGCAUAUCAAUAAGC --GGAGGAAAAGAAACCAACCGGGAUUGCCUUA-GU-AAC-GGCGAGUGAAGCGGCAAA- AGCUCAAAUUUGAAAUCUGG-UACC-------UUCGGUGCCCGAGUUGUAAUUUGG---- ----------------------------AGAGGGCAA----------------------- ------------C------UUU--GGGGCC--G-UUCCUUG------UCU-AUGUU-CCU UG-GA-------ACAGG------A-CGUC-AUAGAGGGUGAGAAUCCCGUGUGGCGAGG- -AG-UG-CG---------GUUCUU-UGUAAAGUGCCUUCGAAGAGUCGAGUUGUUU---G GGAAUGCAGCUCUAAG-UGGGUGGUAAAUUCCAUCUAAAGCUAAAUAUUGG-CG-AGAGA CCGAUAGC-GAA-CAAGUACAGUGAUGGAAAGAUGAAA-AGAAC-UUUGAAAAGAG-AGU GAAAAAGUACGUGAAAUUGUUGAAAGG---G-AAGGG-CAUUUGAUCAGACAUGGUGUUU ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----UGUGC----CCUCUGCUCCUUG---------------------------------- ---UGGGUAG-GG-GAAUCUCG----------------CAU------------------- ---------------UUCACUGGGCCAGCAUCAGUU----UUGGUGGCAGGAUAAAUCC- AUAGGAAUGUAGCU-UGCCUCG--------------------------------GUAAGU AU-UAUA--GCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACGU-AAGUCAAG GAUGCUGGCAUAAUGG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUAUAUGCCGCCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CGUCUAUGCGA---GUGUUU-GGG--U-----------GUAAA--- --------ACCC-A-U-A-CGCGUAAUGAAA-GUGAACGUA------------------- ---------------------------------------------------------GGU UGGG-GCC--U-C-----------------------------GCAA-------------- -------------------------------G--A---GGU-GCACAAUC----GACCGA UC-C-U----G---AUG----------------------UCUU----------------- --CG--GAUGG-AUUUGAGU-AA-GAGCAUAGCUGUUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAAUAGGGUGAAGCCAGA-GGAAACU-CUGGUGGAGGCUCGU--AGCGGUUCU -GACGUGCAAAUCGAUCGUCGAAUUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCUGCCGAAGUUUCCCUCAGGAUAGCAGAAGC-U--------------- --------------------------------------------------CGUA--UC-- -------------------------AGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUU-C CG--G-GGUCG--AAA--UGACCU-UGACCUAUUCUCAAACUUUAAAUAUGUA-AG--A- A---GUC-CUUGUU---AC-UUAAUU-------------------GAAC-G-U----G-- -G-A-C--------------------------------------------------AUUU -GAA---UGAA--GA--G-CUUUU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGAACGUAG--AGUUAAG--GUGCC--GGAAUA--C A-C-GC-U-CAU--C-AGA-CACC--ACA-AAAGGUGUUAGUUCAUCUAGACAGCCGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCGGCC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUC-A-AGCGU---GUU--------ACC--U AUA-CUCUACC--GUC---A--G----GG-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------UGAUAUGAU-------------------------- -------------------------------GCCC-U-G-A-CG-A--GUAGGC----AG ---G-CGUG-GAGG-UCA------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------ACGA AGCCUAG--A-CCGU-AA-GGU--CGGG-U-CGA-ACGGCC-U--CUAGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GAAGUGGGG-AAAGGUUCCA-CGUCAACAGCAGUUGGA CGUGGG------------UUAGUCGA-UC-C-UAA----GAGAUG--GGGAAG--CUCC- ---------------------------G-U-U--UCAAA---GGC-CUG-AU-------- ---------------------------UUU------------------------------ -----A-----UG-CA-G--G-C-C-----ACCAUC---GA-AA-GGGA-AUC-CGG--U UAA----GAUU-CCG----GAACC-U-GGAU--AUGG-A-UUCUU--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------C-A--CGGUAACGU-A----A-CUGAAU-GUGG-A-GA-CGUCG-G CGCG----AGCCC-UG-GG-A-GGAG------UUAUCUU-------UUC-UUC---UU-- -A------ACA------GC-U------U------A--------U---C-----A--CCCC G-G------A---AU-U--G--G-----U--UUA-U-CCG-GAGAU-GG--GG----U-C -U-U---AUGG-C--U--G-G--A-AG-A-GGC-CAGCA--------------------- ---------CC-UU-----------------------------U--GC-UGG--CU---C CG-GUGCGCU----UG-U--G-A-CGGCCCGUGAAA-A-UCCACAGGAA--GGA------ -----------------------------AUAG--------------------------- -U--UUUC-AUG--CC-A-GGUCGUACUGAUAACCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUAG-UU-GA-UAGA-AUAAUGUA-GAUAAGGGAAGUCGGCAAAA-UAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GUCGGGU-AG-UG-AGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCCUUGG---U--CAGA---C-G-C-AG---C-----G-G-G--CG-UGC- -U--U-G---U-GGA-C-U--GC--UU-G-G-U-GGG-G--------------------- ------------------------------------------------------------ -----------------------------------------------------------C UU-G------------------------------CU-CUGCU-AG-GC---GG-A-C-U- A-CU-UGC-GUGC-CU-U------G-U---U-G--UAG------AC-G-G------CCU- -U-GGUA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGUCU---------------------------- ---------------CUUGU---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------A--G-A--CCG--U----------------CGCUU---GCU-A-CAA--- UUAA--CGA-U-CAAC-UUAGAACUGGUACGGACAAGGGGAAUCUGA-----CUGUCUAA UUAAAACAUAGCAUUGCGA-UGGUCA--GA---AAG------------UGAUGU-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC AUUGUGAAGAGACAUAGAGGGUGUAGAAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UUCG----------------G--CG- CCAG-UGAAAUA-CCACUACCUUUAUAGUUUCUUUACUUA-UUC-A--AUGA--AG--CG GA-----------------------G-C--U-GGAAU--------------UCAU----- --------UUU-C-C--ACG--UU------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CUAGCAU ------------------------------------------------------------ --------------------------------------------UCAA------------ ----G--GUC---C--C---------------------AUUC------------------ --------------G-GGG--CU-------------------GAU-CC-GGGUU-GAAGA -CAU-UGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AACGAUAAC-GCAGA UGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUA-GAACAA-AAGGGUAAAA-G CCCCCUUGAUUU-UGAUUUUC-A---GUGUGAAUACAAACCAUGAAAGUGUGGCCU-AUC G-AUCCUUUA-------------------------G--U------CCCUCG-GAA-UU-- ----------------------------UGAGGCUAGAGGUGC-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUC GAUGUCGGCUCUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG--AAU-------------------------------------------------- ------GUUACC-GCAAUAGUAA--UUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAU AAU-UGGUUUUUGCGGC-UGUCU-GAUC-AGGC-AU--UGCCGCGAAGCUA-CCAUCCGC --U-GGAUUAUGGCUGAACGCCUC--U-AAGUCAGAAUCC------AUG-CUA--GA--- --ACGCGGU---------------------------GA--UUUCUUUG---CU-C--C-- A--CAC-A-AUA------------------------------------------------ ---------------------------------------UA-GAUGGAUAC--------- ---GAAUAA---GG--CGUC---------------------------------------- --------------------------CUUGU----------------------------- -----------------------GGCGU-C--GCUGAACCAUAGCAG-GC-UAGC--A-A CGGUG-CACU-UGGC----GGAAAG---------GCCUU-G--GGU----G--CU--UG- C-UGGC------------------------------------------------------ --------------------------------------GAAUUGCAAUGUCA-------- -UUUUGCGU-GGGG----AUA-AAUC----AUUU--G-UAUACGACUU-AG-AUGUACAA CGGGGUAUUGUAAG-CAGUAGAGUAG--C-C--------------UUGUU--GUUAC--G -AUCUGC--U--GAGAUUAAG-C-CUU---U-GU-UGUC-U--GAU-UU--GU------- -------- >Schizosaccharomyces_pombe -----------------AAACUUUCAGC-AACGGAUC-UCU-UGGGU-CUC-G--CAU-C GAUGAAGAACGCAGC-GAAAUGCGAUACGUA-AUGUGAAUUGCAGAAUU-CCG-U-GAAU CAUCGAAUCUUUGAACGCACAU-UGCGCCUUUGGGUUCU--------------------- -----------ACCAAA------------------GGCA--------------------- -------------------------------------------------------UGC-C UGUUUGAGUGUCAUU--------------------------------------------- ----AUUUGACCUCAAAUCA-GGUAGGACU-ACGCGCUGAACUUAAGCAUAUCAAUAAGC --GCAGGAAAAGAAAAUAACCAUGAUUCCCUCA-GU-AAC-GGCGAGUGAAGCGGGAAA- AGCUCAAAUUUGAAAUCUGG-CAAC-AUUUCUUUUGUUGUCCGAGUUGUAAUUUCA---- ----------------------------AGAAGCUGC----------------------- ------------U------UUG--AGUGUA--GACGAUCGG------UCU-AAGUU-CCU UG-GA-------ACAGG------A-CGUC-AGAGAGGGUGAGAACCCCGUCUUUGGUCG- -AU-UGGAU---------AUGCCA-UAUAAAGCGCUUUCGAAGAGUCGAGUUGUUU---G GGAAUGCAGCUCUAAA-UGGGUGGUAAAUUUCAUCUAAAGCUAAAUAUUGG-CG-AGAGA CCGAUAGC-GAA-CAAGUAGAGUGAUCGAAAGAUGAAA-AGAAC-UUUGAAAAGAG-AGU UAAAUAGUACGUGAAAUUGCUGAAAGG---G-AAGCA-UUGGAAAUCAGUCUUACCUGGG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------UGAGAUCAGUAGUCUCUUCGCGAGACUAUG-----C-A-CUCUGAACCUGUGGU AGGUCAGCAU-CA-GUUUUCGGGGGCGGAAAAAG-------------------------- ---------------------------------------------------------AAU AAGGGAAGGUGGCUUUCCGGGUUCUG------CCUG--G----------------GGAGU GUUUAUAGCCCUUGUUGUAAUACGUCCACUGGGGACUGAGGACUGCGGCUUCGUGCCAAG GAUGCUGACAUAAUGG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------UUUUCAAUGGCCCGUCUUGAAACACGGACCAA GGAGUCUA-G----CAUCUAUGCGA---GUGUUU-GGG--U----------GAUGAAA-- --------ACCC-A-U-C-CGCGAAAUGAAA-GUGAAUGCA------------------- ---------------------------------------------------------GGU GGGA-ACG--C-C-----------------------------CUUGU------------- -------------------------------G--G---CGU-GCACCAUC----GACCGA CC-C-G----G---AAG-UU-------------------UGUC--------------A-- -AUG--GAAGG-GUUUGAGU-AA-GAGCAUAGCUGUUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAAUAGGGUGAAGCCAGA-GGAAACU-CUGGUGGAGGCUCGU--AGAGAUUCU -GACGUGCAAAUCGAUCUUCAAAUUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCUGCCGAAGUUUCCCUCAGGAUAGCAGAAAC-U--------------- --------------------------------------------------CAGA--UC-- -------------------------AGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUC-U UG--G-GGAAG--GAA--UUUCCU-CAACCUAUUCUCAAACUUUAAAUAUGUA-AG--A- C---GCC-CUUGUC---GC-UUAAUU-------------------GGAC-G-U----G-- -G-G-C--------------------------------------------------CAUC -GAA---UG-A--GA--G-UUUCU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGAACGUGA--GGUUAAG--GUGCC--GGAAUG--U A-C-GC-U-CAU--C-AGA-CACC--AGA-AAAGGUGUUAGUUCAUCUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUU-A-AGCGU---ACU--------ACC--C AUA-CCUCACC--GUC---U--G----GG-U----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------UAGCUUUGAGAA----------------------- -------------------------------GCUC-A-G-A-CG-A--GUAGGC----AG ---G-CGUG-GAGG-UUU------------------GU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------ACGA AGCCUUG--G-GCGU-GA-GCC--UGGG-U-CGA-ACAGCC-U--CUAGUGCAGAUCU-U GGUGG-AAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GAAGUGGGG-AAAGGUUCCA-UGUGAACAGCAGUUGGA CAUGGG------------UUAGUCGA-UC-C-UAA----GAGAUA--GGGAAG--CUCC- ---------------------------G-UAU--GAAAGU--UGC-ACG-A--------- ---------------------------UUUU----------------------------- -----------U--CG-U--G-CCU-----CCUAUC---GA-AA-GGGA-AUC-CGG--U UAA----UAUU-CCG----GAACC-A-GAAG--GUGG-A-AUCAA--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------C-A--CGGCAACGU-A----A-AUGAAG-UUGG-A-GA-CGUCG-G CGGG----AGCCC-UG-GG-A-AGAG------UUCUCUU-------UUC-UUU---UU-- -A------ACA------AA-C------C------A--------U---UGAACUA--CCCU G-A------A---AU-C--G--G-----U--UUA-U-CCG-GAGCU-AG--GG----U-A -U-G---GUGU-U--U--G-G--A-AG-A-GUU-CAGCG--------------------- ---------CC-UCA----------------------------U--GC-UGA--AU---C CG-GUGCGCU----CU-C--G-A-CGGCCCUUGAAA-A-UCCAACGGAA--GAA------ ------UGGACC-----------------UUCG------------------GGUCCUUG- -U--UUUC-ACA--UC-U-GGUCGUACUCAUAACCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUAG-UU-GA-UAGA-ACAAUGUA-GAUAAGGGAAGUCGGCAAAA-UGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GUUGGGU-AC-GU-UGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCCUUGG--AA--CCUGAA-CGG-U-U----G--C--U-G-G--A--CUG- -A--G-C---GUGGA-C-C--GA--UG-U-C-U-UUU-CUCG-CCU-------------- ------------------------------------------------------------ -----------------------------------------------------------U UC-G-----------------GG-G--U-G--A-GA-AGGGA-UG-UU---GG-A-C-C- U-GC-UUG-GACC-UU-G------G-C---G-G--CCGGG----AA-G-U------CCU- -U-GGUC----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGGCUU---U--U--C--U---C-C-------- --------------UUCUC----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------G-G----- -GGA--UUA-U--G-C--UCU--UA---------------C-UGG---CGU-A-CGU--- UUAA--CAA-C-CAAC-UUAGAACUGGUACGGACAAGGGGAAUCUGA-----CUGUCUAA UUAAAACAUAGCAUUGCGA-UGGCCA--GA---AAG------------UGGUGU-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAACUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAAACCACAG--CCUGGGGAA CGGGCCAGGCAAAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC AUUGUGAAGAGACAUAGAGGGUGUAGGAU-AAGUGGGAG-UA-U--G------U------ ------------------------------------------------------------ ----------------------------------UUCG-----------G-CAUA--CG- CCGG-UGAAAUA-CCACUACCUUUAUCGUUUCUUUACUUA-AUC-A--AUGA--AG--CG GA-----------------------A-U-UG-GGAU---------------UUAU----- ---------UU-C-C--C-AUAUU------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CUAGCG- ------------------------------------------------------------ --------------------------------------------UUAA------------ ----A--GUU---U-----------------------CUUCGC----------------- ----------------GAA--CU-------------------GAU-CC-GCGUU-GAUGA -CAU-UGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AAAGAUAAC-GCAGG UGUCCUAAGGGGGACUCAUCGAGAACAGAAAUCUCGAGUA-GAAUAA-AAGGGUAAAA-G UCCCCUUGAUUU-UGAUUUUC-A---GUGUGAAUACAAACCAUGAAAGUGUGGCCU-AUC G-AUCCUUUG-------------------------U--U------CCCUCG-AAA-UU-- ----------------------------UGAGGACAGAGGUGC-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUUCAUAGCGACGUUGCUUUUUGAUUCUUC GAUGUCGGCUCUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG-AAGU-------------------------------------------------- ------GUCGUC-GCAAUGGUAA--UUCAACUUAGUACGAGAGGAACCGUUGAUUCAGAU CAU-UGGUAUUUGCGGC-UGCCU-GACA-AGGC-AA--UGCCGCGGAGCUAUC-AUCUGC --C-GGAUAACGGCUGAACGCCUC--U-AAGCCAGAAUCC------GUG-CCA--GA--- --AAGCGAC---------------------------GA--UUUUUUG----GU-C--C-- G--CAU-G-AUU------------------------------------------------ ---------------------------------------UA-UAUGUAUAA--------- ---AAAUA----GA--GGUAG------------------------------G--A----- --------------------------CUUGU----------------------------- ---UC-----------------CUACUC-U--CCUGUAUCGUAGAAG-AU-GGGC--G-A UGGUU-GAUG-AAAC----GGAAGU---------GUUUU-A--UUG----A--CU--UG- U-CCAU------------------------------------------------------ -------------------------------------GAAAUUCCAUUGAAA-------- -UCUUGUGC-GGAA----UCG-AAUC----CAUU--G-CAUACGACUU-UA-AUGUGGAA CGGGGUAUUGUAAG-CAGUAGAGUAG--C-C--------------UUGUU--GUUAC--G -AUCUGC--U--GAGAUUAAG-C-CUU---U-GU-------------------------- -------- >Tetrahymena_thermophila --------------AGAAAAUUUUCAAC-GGUGGAUA-UCU-AGGUU-CCC-G--UGA-C GAUGAAGAACGCAGC-GAAAUGCGAUACGCA-AUGCGAAUUGCAGAACC---G-C-GAGU CAUCAGAUCUUUGAACGCAAGU-GGUGGAGGUG---------------------U----- ----------AAAAACC------------------UUCA--------------------- -------------------------------------------------------UGU-U UGUUUCAGUGUGGA---------------------------------------------- -----ACUACACCUGAAACA-AGCAAGAUU-ACCCGCUGAACUUAAGCAUAUCAGUAAGC --GGAGGAAAAGAAACUAACUAGGAUAGCCCCA-GU-AAU-GGCGAAUGAACAGGCUAA- AGCUCAAAGUGAAAAUCUGAAG-UG-----GUCAACACAACAGAAUUGUAAUCUAA---- ----------------------------AGGGUCAAC----------------------- ------------C------UGA--AACUAA---GCUCCUCU------CAU-AAGUU-CCU UG-GA-------ACAGG------A-CGUC-AAAGAGGGUGACAACCCCGUAGUCGGAGA- -GGAAGGCU---------GGUG----UAAGGGAGAUUUCAAAGAGUCGGGUUGUUU---G GGAUUGCAGCCCUAAG-UGGGAGAUAAACUUCUUCUAAAGCUAAAUAUACA-CG-GGAGA CCGAUAGC-GAA-CAAGUACUGCGAAGGAAAGAUGAAA-AGAAC-UUUGAAAAGAG-GGC UAAA-AG-ACUUGAAACCGUUGAGAAG---G-AAGCU-GUAGAAGAGCAAUAAACUGGAC GGC--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GCAUAAGGGGG-A-A-GUACUAAUCACUGCA GAGUCGAUAC-G---UAAAAGGUCGAUGAGUAAGGAA--A------UGGUACAGAACUU- GC-------------UACG-CCGGUCAGAAGA-------------------CAAAAUG-- -----------GGU-UCAGAUUGAAGGAGUCACCUG--AGA-----UCG--GGCAGCAAU GCAGA----U-CAAAAGGAAAACUUCAAA-CUGGACUGAGGGG-----CCU------AAG GGCG-----AUUUUGUC------------------AAAAUGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CUUCUACUGACCCGUCUUGAAACACGGACCAA GGAGUCUA-U----CAAUUAAGCGA---GUGAUA-GGG--U----------GGAAAA--- --------ACCC-G-U-C-CGCGAAACGAAA-GUGAGUACAA------------------ ---------------------------------------------------------GGU GCCAAGCC----------------------------------GCAA-------------- --------------------------------------GGUAGCAGCAUC----ACCCGA CC-U-U----G---AGU-C--------------------UCC------------------ -GAC--GAAGG-GUUCGAGG-AA-GAGCUUAAUUGUUAG-GACCCGAAAGAUG-GUGAAC UACGCUUGAAUAGGGUGAAGCCAGG-GGAAACU-CUGGUGGAAGCUCGU--AGCGAUACU -GACGUGCAAAUCGUUCGUCAAAUUUGAGUGUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCUCUCAGGAUAGCAAGAGC-A--------------- -------------------------------------------------AGUAC--GC-- -------------------------AGUUUUAUUAGGUAAAGCGAAUGAUUAGAGGAC-U CG--GGGUU-C--CAA--GAAUCU-CGACCUAUUCUCAAACUUUAAAUUGGUA-AG--A- G---CCGCGGAGUUU--AC-UUAAAU-------------------GAAC-U-C----U-- -C-G-G--------------------------------------------------GAAG -AAU---GC-A--GU--G-CUCUU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-AGGGA----UGA--ACCUAACGUUG--AGAUAAG--GCGCC--CAAAUG--C A-C-GC-U-CAU--C-AGA-UACC--ACA-AAAGGUGUUGGUUCAUACGGACAGCAGGAC GGUGGCUAUGG-AAGUUAGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUG-A-AGCGU---GUU--------GCC--G AUA-CUCAACC--AUC---A--G----AG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AAAUGCGAG-------------------------- -------------------------------GCUU-U-G-A-UG-A--GUAGGA----GG ---G-CGUG-AUCG-UU-------------------GC-C-------------------- ------------------------------------------------------------ --------------------------------------------------------UAGA AGUAUUG--G-GCGU-GA-GCC--UAUA-U-GGA-GCAGCG-A--UUAGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACC-GAAGUGGAG-AAGGGUUCCA-UGAGAACAGCAAUUGUU CAUGGG------------UUACUCGA-UC-C-UAA----GACAUA--GGUUAA--CUCC- ---------------------------U-U-G--CAAUACA-AGA-AGA-CA-------- ---------------------------UU------------------------------- -----C-----G--UU-U--U-C-G------UUGUC---AA-AA-GGGA-AUG-AGG--U UAA----UAUU-CCU----CAAGC-U-GGAC--GUGGUA-UA------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------GA-G--CGGUAACGC-A----A-AGAAAC-CCGG-A-GA-CGUCA-G CAGG----UGUCA-CU-GG-A-AGAG------UUAUCUU-------UUC-UUU---UU-- -A------ACA------UA-C------U------A--------U---G-----G--CCAU G-A------A---AU-U--G--G-----A--UUA-U-CCA-GAGAU-AUC-GG----C-U -G-U---AUGU-A--U--G-G--C-AG-A-GCA-GCUCA--------------------- ---------CC-CU-----------------------------A-AGA-GCU--GU---C AG-UUGCGCA----CC-U--G-A-UGACCCUUGAAA-A-UCUGGGGGAG--AC------- -----------------------------AUA---------------------------- -A--UUUC-ACG--CC-A-GUUCGUACCCAUAACCGCAUCAGGUCUCCA-AGG-UUAGCA -G-CCUCUGG-UC-CA-UAGA-ACAAUGUA-GAUAAGGGAAGUCGGCAAAU-UGGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UG--A-GG-AUCGGGU-AU-AA-AG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GCUUUGU---A--A-U----G-A-UAUCCAAG--C--U-U-G--UU-UGU- -U--A-G---U-GUG--------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G CA-A--------------------------------------------------C-A-U- G-CU-GAU-AGAC-UU-G------C-GAACGAU--GAA-------U-U-U------GCA- -A-GGUA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGU------------------------------ ---------------UUCG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------G--CCG-------------------U-CUU---UAU-A-CAA--- UUAA--CGA-U-CAAC-UCAGAACUGAAGCGGACAAAGGUAAUCCGA-----CUGUUUAA UAAAAACAAAGCAUUGUGA-CGGCCU--CA---A-C------------AGGUGA-UG-AC ACAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAC-------------GCA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAAUG AG-A--UUACC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAACCCACAG--CUAAGGGAA CGGGCUUAGAAUAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUAAC UUUGUGAAAUGGCACGUGGGGUAUAGCCU-AGGUGGGAG-A------------------- ------------------------------------------------------------ ----------------------------------GCAA----------------U--CG- AUCC-UGUAAAA-CCACUACCCACGUAGUCAUUUUGCUUA-UUU-C--GUGA--AG--AA AA-----------------------G-A--C-UGGU---------------GCAA----- ---------AC-C-A--G-U--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CUAAAG- ------------------------------------------------------------ --------------------------------------------UUAA------------ ----G--GUC---A--U---------------------UU-A------------------ --------------U-UGA--CU-------------------GAU-UU-UUGCG-AAAGA -CAU-GGUUAGGGGGGGAGUUUGUCUGGGGCGGAAUGCCUGUUA-AACCAUAAC-GCAGG CGUCCUAAGUGUAGCUCAGUGAGAACGGAAAUCUCACGUA-GAACAA-AAGGGUAAAA-G CUACAUUGAUUU-UGAUUUUC-A---GUAGGAAUACAAACCGCGAAAGCGUGGCCU-AUC G-AUCCUUUA-------------------------A--C------U-UUAC-AAG-UU-- ----------------------------UUAAGCUAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGAGUUCAUAUCGACGUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACAACGUGUCGGAUUGUUCACCCG CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGAAA-C-------------------------------------------------- ------GAUGUU-GCGACAGUAA--UUUAAGUUAGUACGAGAGGAACACUUAAAUCAGAU AAU-UGGUAAAUACGGU-UGUCU-GAAA-AGAC-AA--UGCCGUGAAGCUA-CCAUCUGU --U-GGAUUAUGACUGAAGGCCUC--U-AAGUCAGAAUCC------AUG-CUG--GA--- --AAGCAAU---------------------------GU--CUAA-------GU-G-UG-- A--UGA-U-AAAC----------------------------------------------- ------------------------------------------------------------ ---------------------GAAAAAAA---------------------AU--A--A-A -A-------------------------AUUA--------------------------A-- G--UUCGA---AAGGUAGAG---------------------------------------- ----C-GGGGAAGAGC---GAAAAA--------GCUUGA-C--CUU-------------- ------------AACUGCUAAU---CGUAA--------UUCCA----------------- ------------------------------------------------------------ AAUUAUCAU-CUAC-----GU-AAAUC---UUUU--G-UAGACGACUU-AA--CAUGGAA C-GGGUAUUGUAAG-CAUGAGAGUAG--A-A--------------UU--U--CCUAC--G -AUCUGC--U--GAGAUUCAG-C-CC------GUCUCCU-UA-GAU-UU--AUCU----- -------- >Thalassiosira_pseudonana --------CU---AUUACAACUUUCAGC-AAUGGAUG-UCU-UGGAU-CCC-A--CAA-C GAUGAAGAACGCAGC-GAAAUGCGAUACGUA-AUGCGAAUUGCAGGACC-UCG-U-GAAU CAUCAAACUUUUGAACGCACAU-UGCGCUUUUGGGUAA----------------U----- ----------GCCCAAG------------------AGCA--------------------- -------------------------------------------------------UGC-U UAUCUGAGUGUCCC---------------------------------------------- --------------------------GAAU-ACCCGCUGAAUUUAAGCAUAUUAAUAAGC --GGAGGAAAAGAAACUAACAAGGAUUCCCCUA-GU-AAC-GGCGAGUGAAGCGGGAAG- AGCUCACCAUGUGAAUCUAUGUAAC--CCUUCGGGGUGCAUCGAAUUGUGGUCUGG---- ----------------------------AGAAGUACU----------------------- ------------G------UCG--GCCGUG----GUUCCGG------GCC-AAGUC-UCU UG-GA-------AAAGA------G-CAGC-UGAGAGGGUGAAACUCCCGUUCUUGCCUG- -GAAACAUU---------GUGCCU-UGGCAUAUGCUUUCUAUGAGUCGAGUUGCUU---G GGAUUGCAGCUCAAAU-UUGGUGGUAAAUUCCAUCUAAAGCUAAAUAUUGG-UG-GGAUA CCGAUAGU-GCA-CAAGUACCGUGAGGGAAAGAUGCAA-AGAAC-UUUGAAAAGAG-AGU UAAAGAGUACCUGAAAUUGUUGAAAGG---G-AAGCG-AAGGAAACCAGUGCC-----AA CG--UUG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------UGUCAUACUUUC- UCUGCCG-------CUU-------------------------G--------CGGUA---- --GGGAC----GCUGUGGCGCUACAUGGGUCAGCAU--C---------------GGCUUU GUG--------CUUGGGUCAAACGUUCAGUUGGUAGGC--GGCU----CC-------UCG GA-GUUAG-----UG---CCU-UCUGUUCAU---------GUCCUGGGU----------- ------------------------------------------------------------ ------CGGGCUGAGGUCAGUCACUAUGU---------GCUCGUGAUGCUGACG------ --------------------------------------AAAUGG---------------- ----------------------------UUUUCUUUACCCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CAUAUGUGCGA---GUACAA-AGG--U----------GGCAA---- --------ACCU-G-C-G-UGCGCAAUGAAA-GUAACA---------------------- -------GU------------------------------------------------GGU UGGAUCCC----------------------------------UCCG-------------- --------------------------------------GGGUGCACAAUC----CGCCGG CC-A-A----U---AUC-C--------------------UUCG----------------- -GGA--GAAAG-GUCUGAGU-GU-GAGCAUACAUGUUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGAGUAGGGCGAAGCCAGG-GGAAACU-CUGGUGGAGGCUCGU--AGUGAUUCU -GACGUGCAAAUCGAUCAUCAAAUUUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAAUUUCCCUCAGGAUAGCUGCAA--U--------------- ---------------------------------------------------UA---AU-C -------------------------AAUUUUAUCAGGUAAAGCGAAUGAUUAGAGGUU-C CG--GGGGC-G--UAA--UGCCCU-CGGCCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---CCC-AGGGUU---GC-UUAAUU-------------------GAAC-C-C----U-- -G-G-C--------------------------------------------------GUCG -AAU----G-A--AG--G-UUGCU-AGU-GGG-CCA--CA-CCGGG-UAAGCUGGUU-UG -GCGAUG-CGGGA----UGA--UCCGAACGUUU--AGUUAAA--GUGCC--AAAGUA--U U-C-GC-U-CAC--CUAGA-UCCC--ACA-AAAGGUGUUGGUUCAUUUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUG-A-AGCGA---AUC--------ACU--U AUA-CUAAACC--ACC---A--G----GC-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AAGUGCCAA-------------------------- -------------------------------GGCC-U-G-G-UG-A--GUAGGA----GG ---G-CGUG-AAGG-UU-------------------GU-U-------------------- ------------------------------------------------------------ --------------------------------------------------------GUGC AGCUUAU--A-CCGU-GA-GGU--UAAG-U-GAA-ACGGCC-U--UUAGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GAAGUGGGG-AAAGGUUCCA-CGUGAACAGCAAUUGGA CGUGGG------------UUAGUCGA-UC-C-UAA----GAGAUA--GGAGAA--AUCC- ---------------------------G-U-U--UCAAA---GUGAGUG-UUC------- ---------------------------UUCG----------------------------- ---GUU-----C--GC-U--C-C-G-----CCUAUC---GA-AA-GGGA-AUC-UGG--U UAA----UAUU-CCA----GAACC-A-GGAC--GUGG-A-UAUU---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------GA-G--UGGUAACAC-A----A-GCAAAG-CCGG-G-UA-CGAUG-G CGGG----AGCCC-UG-AG-G-AGAG------UUCUCUC-------UUC-UUC---UU-- -A------ACA------AG-C----ACA------C--------U---A-----A--CCCU G-G------A---AU-C--G--G-----A--UUG-A-CCG-GAGAU-AG--GG----U-- -U-G---GAGU-C--U-UG-G--G-AA-AGGUG-GA-UA--------------------- ---------GU-UUU----------------------------U--GU--CU--GCU--U CG-GUGCGCU----CU-C--G-U-UGUCCCUUGAAA-C-CCCGGUGGCG--UGA------ -----------------------------CUUA--------------------------- -U--UCGC-ACC--CC-U-GGUCGUACUGAUAACCGCAUCAGGUCUCCA-AGG-UUAGCA -G-CCUCUAG-UU-GA-UAGA-AUAAUGUA-GGUAAGGGAAGUCGGCAAAA-UAGAUCCG UAACUUCGGG-AAAAGGAUUGGCUC-UG--A-GG-GUUGGGC-CU-GG-GGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------UCCCUCG---U--U-U----G-A-U-GU---U--G--C-G-A--GG-AC-- -U--A-G---G-AGA-G-A--CU--GG-C------------------------------- ------------------------------------------------------------ -----------------------------------------------------------U CAC--------------------------------------G-CU-GG---AC-U-U-U- C-CA-G-G-UCU--UC-C------U-U---C-G--G-A-------C-G-G------CGG- -G-GGGA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UGUG----------------------------- ---------------CUUG----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------C-A--CUU-------------------U-CCC---CAGUG-CG---- UAGAA-CAA-C-CAGC-UCAGAACUGGAGCGGACAAGGGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUUGCGA-CGGCCG--GA---G-A------------CGGUGU-UG-AC GCAAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GGA A---------------UUCAA-CCAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAAUG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUCUAGCGAACCCACAG--CCAAGGGAA CGGGCUUGGAAUAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCCGAC GUUGUGAAAUGACUUAUGAGGUGUAGAAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UUCG----------------G--CG- CACA-UGAAAUA-CCACUACUCGUAAUGUUGUUUUACUUA-UCA-U--GUGA--CG--UA GC-----------------------A-C--C-CAGCCGUCU----------UCAC----G -GG--C--GCC-U-G--G-U--U------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------CUAGAU- ------------------------------------------------------------ --------------------------------------------UUAA------------ ----G--UCA---A------------------------CUUGU----------------- ----------------UUG--GC-------------------GAG-CU-ACGCA-UGAGA -CAA-CGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AACAAUAAC-ACAGG UGUCCUAAGGUCAGCUCAAUGAGAACAGAAAUCUCAUGUA-GAACAA-AAGGGUAAAA-G CUGACUUGAUUU-UGAUUUUC-A---GUACGAAUACAAACCGGGAAACCGUGGCCU-AUC G-AUCCUUUC-------------------------A--G------UUUUUA-GAA-UU-- ----------------------------UGAAGUGAGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGCCAAGCGUUCAUAGCGACGUUGCUUUUUGAUUCUUC GAUGUCGGCUCUUCCUAUCAUUGUGUCGCAGAAGUCACCAAGUGUAGGAUUGUUCACCCA CUAACAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUGA-A-U-------------------------------------------------- -----UGUUGUC-CCGACAGUAA--UCCAACUUAGUACGAGAGGAACCGUUGGUUCAGAU AUU-UGGUA-AUGCGGU-UGGCU-GAAC-AGCC-AA--UGCUGCAAAGCUA-CCAUCUGU --A-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC------AUG-CUG--GC--- --A-GGGAU---------------------------GA--UAACCCC----CU-U--G-- A--CCA-C-UGUU----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------ACCUG-A--GUA -GC-A--AUA---G----U-------CACGU------A-----UCAACAC-CA-----CC CC-CU------------------------------------------------------- --GGU-AGC----------GCUGUAC-------------------A----CUAAA--GU- A-CAAGCUU-----GC-CGAAA---CACAA--------UUUCC----------------- ------------------------------------------------------------ AAUGAUGGU-CAAG-----UC-AAAUC---CUUU--G-UAGACGACUU-AA-UUAAGGAA CGUGGUACUGUAAG-CAUGAGAGUAG--C-C--------------UCUGU--GCUAC--G -AUCUGC--U--GAGGUUCUG-C-CUC--------------------------------- -------- >Trypanosoma_brucei ------------------AACGUGUCGC-GAUGGAUG-ACU-UGGCUUCCU-A--UUU-C GUUGAAGAACGCAGC-AAAGUGCGAUAAGUG-GUAUCAAUUGCAGAAUC-AU--U-UCAU UGCCCAAUCUUUGAACGCAAAC-GGCGCAUGGGAGAAGC---------------UCUCUC G-----AGCCAUCCCCG------------------UGCA--------------------- -------------------------------------------------------UGC-C ACAUUUCUCAGUGUCGAA------------------------------------------ -----UUCAGACCUGAGUGU-GGCAGGACC-ACCCGCUAAACUUAAGCAUAUUACUCAGC --GGAGGAAAAGAAAACAACCGUGAUUCUCUCA-GUCAGC-GGCGAGCGAAGAGGGAUUC AACUCGUUGCCGAAUCGGGUCU-UACAUG--------ACCUCGAACUGUGGCACCA--UU UUUGUGGCCGUUCUUAUAGGGCUGGUGCAGGCGUGGC----------------------- ---------GGAAUUCAAUUGC--AAAGCA--AACCCGUUG------CUG-AAC-ACAUU UA-CAACCCUUCAUGUGAGUAUUG-AGCC-AAAGAAGGUGUCAGCCCAUUACAUUCCUUA GCCACGGAGCCUACGCG-CCUCCU-CAUGUUCGGU-CCAAGAGAGUAGCACUGUUU---G GGAAUGCAGUGUCAAGCCGGCAGGUAUUUGUCUGCCAAGGUUAAAUAUAGAGUAGGAAGA CCGAUAGC-GAA-CAAGUAGCGUGAGCGAAAGUUUGAAAAGUAC-UUUGGAAAGAG-AGU GACAUAGAACCUGAAAUCGUGACAACGA--C-AAUGG-AAGUACCUUCAUUUCUUUUUU- -UUA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------CGGCCAGACCCAACC------UCGCCGCGCAAUU- U-------------------CCUUCCGGGGCUCAACAUCCGGGUUUUC----ACU----- -----GUGCG-GGUUUCUCUUUUGAGG--UCA--UG--GGG----------UGCGUGAGU GGG------CGGAA---UAAA-GGGUCGGUGUG-----------------UUGUG--U-- -GUGGGUUUUUCUCUCAC----UCUCUUCCUC---C----UUCCCUGUCCGUG------- -----------CGUCUCGACGCUGGCGAUGGAAAUGG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GGUGCCCCCACCCGUCUUGAAACACGGACCAA GGAGUCAA-A----CAGACGCGCAA-GGGAGGAGUAUG--U---------AUGUGAGA-- --------ACUCUU-U-U-CUCGUACUGAAA-GGGAGGUGUGAUU-UUA----------- ------CACC-----------------------------------------------CGU GGCGUGCG--C-A-A---U-----------------------UUCUC------------- -------------------------------U--U---UUUUGUGUUUUU----GCCCAA CG-C-C----G---GCC-G--------------------GCCC----------------- -CCC--GUGGG-CUGCGCGC----GAGUGUGCCUGUUUG-GACCCGAAAGGUG-GUGAAC UAUGCCUGAACAAGGUGAAGCCCGG-GGAAACC-CCGGUGGAGGCCUGU--AGCGAUGCU -GACGUGCAAAUCGCUCGUACGAUUUGGGUAUCGGAGCGAAAGACUCAUCGAACCACC-U AGUAGCUGGUUCACGUCGAAGUUUCCCUCAGGAUAGCUGGUGC-U--------------- -------------------------------UG---------------UCUUUA--A--- ----GA-------------------AGUAUUGUGCGGUAAAGCAAAUGAUUAGAGGCA-U UG--GUGUU-C--UUG--UAAUAU-CGACCUAUUCUCAAACUUUAAAUGUGCA-AA-CA- A---CCC-AGCCUU---AG-UUAUUU-------------------UAAC-AAGGCUUUUG GGUA-C-------------------------------------------------AUAAG -AAU---UG-A--G---G-CACCA-AGU-GGG-CCU--UC-UUCGG-UAAGCGGAGC-AG -GCGAUG-CGGAA----UGA--ACCG--CUUAG--GGAUAUGUGGCGUCAAAACUUG--U G-G-GC-U-CAU-UCUCGA-UACG--UGAAAAGGGUGUUGGUGGAUAGGGACAGUUGGAC GGUGGCCAUGG-AAGUCGGCAU-CCGCUAAGGAGUGUGUAACAACUCACCAACC-----G AAUCCACCGGCCCCGAAAAUG-GAUGACGCUU-A-AGCCCCAUGUGCGUGAUUGCCCAUU AUUCCUUUGGU--GAG---G--G---CGG-C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------UAUAUUUCUUUGUGAGAAAGUGUA-------------------------- -------------------------------GCCC-U-C-C-CG-A-UGUAGACG---UG ---G-CGUG-GGGG-UG-------------------AG-G-------------------- ------------------------------------------------------------ --------------------------------------------------------ACGA AGCCGAU--G-GCGC-GA-GCC-UCGGA-U-GGA-CCCGCC-U--CUAGUGCAGAUCU-U GGUUG-GCGUA-GCA-A--AG-AUCUAA-CGGAAUAUUUUUUCUUAAAUGC-AAC----- ----------GUUGGA-UACU-GGAGCGGGG-AAGGAUUUCG-UGCCAACGGCACUCGUA CACGAG------------UUGUUCGG-UCAC-UGA----G-CACA--ACGUUA--CACC- ---------------------------G-UUU--UGUUAG--GAA-AGU----------- --------------------------GAAGGU---------------------------- -----G-----G--UCGG--C-GCA----CUUCUCCCUUUU-UU-GGGG-UUU-GUGUGU UUUACCGGCUUAUCU----GAAAA-G-GGGC-AACAG-AGAACC---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------ACUG--UGGAAAUGCGA---AACACUUGC-CAGG-U-GAC--CCA-U CCAU----CCUCC-CA-CG-G-UGAG------CUUUCUU-------UUC-ACC---AU-- -AAUCCACAUCU-CCGGCC-UUG-CUGG------G--------G---C-UUGGGC-CUCU C-G------ACUUCU-C--G--C-----G--UUA-C-UCG-GAGCG-GG--GG----C-U -C-A---A-GA-U--U--G-A--A-AA-AUGCA-GCUCA--------------------- ---------CC-CU-----------------------------A-CGU-ACU--GU---C CU-UUG-UUG----UG-A--G-UUCGGCGCAU-UAA-A-GCAAAAAC-C--UGGGGUG-- ------------------------------------------------------------ -U--CCCA-ACU--GC-A-GACCGUACUCAUCACCGCAUCAGGUCCCCA-AGC-AUCGAA -U-GCUCUGG-UA-CA-UAGA-GAAAGGUACACUCAGGGAAGUCGGCAAAA-UAGAUGCG UAAGUUCGCA-AGAAGCAUUGGCUC-UG--A-GG-GCAAAGU-GG-GGGUC--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------CACAGGAGGG---------------------CCAGUGUCCUUUCGUGCG CGGCCGUUUUCUGCGUUU-U--GUUGUUUU-GGC-GUUCGC--G--C-C-UUAGC-ACA- -UACG-C---G-GCG-A-C--CG--UU-U-U-G-CUC-GGAA-C---------------- ------------------------------------------------------------ -----------------------------------------------------------G UG-A--------------------------AGG-CU-ACCCU-CC-CG---AG-C-C-G- UAUCUACUAACCU-CC-UU---CUG-G---U-G--U-GU------U-G-U------UUU- -U-ACGUC---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------UCACUC---C----------------------- ---------------CGCGC---------------------------------------- ------------------------------------------------------------ ----------------------------------------------------AGGUG--- -UUU--U-C-G--C-U--UCCUUUU---------------U-UGGUUGCGC-A-CCU--- ACAAA-UUG-C-CAAC-UCAGAACUGCUUACGGC--GGGGAAUCCAA-----CUGUAUAA UUAAAACAUAGGUUUGUGA-UG--CAU-CC---AAG------------UGGUGUAUG-UC GCAAACUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAC-GUGAC-------------GAG A---------------UUCAC-CGACGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCUUC-CAAUUAGAGACGCGCAUGAAUGGAUUAAUG AG-A--UUCCC--UCUGUCCCGA-GU-UAC-UAUCUAGCGAAACGACAG--UCAAGGGAA CGGACUUGAAGGGCUAAGCGGGGAAAGAAGA-CCCUGUUGAGU-UUGACUCCAGUCUGGC UCUGUGCGGCGACUUUGGAGGUGUAGUAU-AGGUGGAAG-CG------------------ ------------------------------------------------------------ ----------------------------------CA-----------------AG--CU- CAAA-UGAAAUA-CCACCACUCGGAACGUUGCUUCACUUA-UCG-A--AUGA-AGAGACC AAUGGUUGUUUUGCGCAGUCUUCGGG-C-UGUGCGCCGUCUAGGCUGGGCAUAAU----- -UG--U--GGU-G-U--U-U--C------------------------------------- ------------------------------------------------------------ ---------------------------------------UUUCACCGCCACGGGAGGGGU GUUGGUUUUUUAUCCUUCUCUCCGUUUCUCCUUUUCUCUCUUUCUCCCUUUUUUUGGGC- ------------------------------------------------------------ -------------------------------GUUUGAGGGUUGGUGAC----------CC GUGGG--CGC---CCAG---CCGUGCGGAACU------UCUG-----CGCCAAC--G--- G--G--G-------U-GGGAACU---UUUCGUUUCUUCUCCGGAGUCU-UGUUU-CGAGA -CAUCUGCCAGAUGGGGAGUUUGGCUGGGGCGGCAUAUCUGUUA-CACGACAAC-GCAGG UGUCCUAAGGCGAGCUCAGUGGGAACAGAAAUCUCACGUG-GAACAC-AAGCGUAAAU-G CUUGCUUGAUUAACGAUUUCC-A---GUACGAAUCGAGACUGCGAAAGCAAGGCC--AGC G-AUCCUUUG-----------------------CGA--A------GAACAG-GAA-AU-- -------------------AUGAACAAAUCAUACCAGAGGUGU-CAG--AAUAAUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAACCUAGCGCCGCAGAAGACGCUAAGGGUUGGAUUGUUCACCCA CUGACAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUGGUUUUACCCUACUU GGCUG-GAGAUUGCGAGUAAAAGAUUAUCCGCGCAAAGCGGAGUGAGAUUGUGAAGGGAU CUCGCAGGCAUC-GUGAGGGAAG--UAUGGGGUAGUACGAGAGGAACUCCCAUGCCGUGC CUC-UGGUUUCUGGAGU-UUGUC-GAAG-GGCA-AG--UGCUCCGACGCUA-UCGCACGG --U-GGUUCUCGGCUGAACGCCUC--U-AAGCCAGAAACC------AGU-CCCAAGA--- -C--CGGGU---------------------------GC--CCGUU------CU-C--GAA U--CGC-CACUU------------------------------------------------ ---------------------------------------CU-CUUAUCUGG--------- ------UGG---GC--UCUGCCCGCCCUU---------------------GUC-G--G-- -C--G---------------------CCCA---------------------------GUA C--CUUCAU--UUUCACAAGAUCUUUUG-UC-----------------CC-UCUC--C-A --AAC------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAGAGUAC-----------AU GCAUGGGCU-GGCA------U-GAGCG---GCAC--GCUCCACGACCG-UG-GGGCUCGA -GGGGCACUUUACG-UCCCGAGGCGC-------------------UGAAC---CUU---G -AUGCUU--GG-AAUUUCAUG-C-UCA--GGGACUUUU---------------------- -------- >Xenopus_laevis --------------UCGCGACUCUUAGC-GGUGGAUC-ACU-CGGCU-CGU-G--CGU-C GAUGAAGAACGCAGC-UAGCUGCGAGAAUUA-GUGUGAAUUGCAGGACA-CA--U-UGAU CAUCGACACUUCGAACGCACCU-UGCGGCCCCGGGUUCC---------------U----- -----------CCCGGG------------------GCCA--------------------- -------------------------------------------------------CGC-C UGUCUGAGGGUCGCUC-------------------------------------------- ----CUCAGACCUCAGAUCA-GACGCGGCG-ACCCGCUGAAUUUAAGCAUAUUACUAAGC --GGAGGAAAAGAAACUAACCAGGAUUCCCCCA-GU-AAC-GGCGAGUGAAGAGGGAAG- AGCCCAGCGCCGAAUCCCGCGCCCG--------CCGGGCGCGGGACGUGUGGCGUA-CGG G---------------------------AGACCGGAC----------------------- ------------C-CCC--CCG--GCGCGG---CUCGGGGG------CCC-AAGU--CCU UCUGA-------UCGAGGCCC--A-GCCC-GCGGACGGUGUUAGGCCGGUGGGCGG---- -CCCCC-GG---------CGCGGC-GGGACCCGGUCUCCUCGGAGUCGGGUUGUUU---G GGAAUGCAGCCCAAAG-CGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGG-CA-CGAGA CCGAUAGC-GGA-CAAGUACCGU-AAGGAAAGUUGAAA-AGAAC-UUUGAAGAGAG-AGU UCAAGAGGGCGUGAAACCGUUAAGAGG---U-AAACG-GGUGGGGCCGUGCGGUCCGCCC GG-----AGGAUUCAAC-CCGGCGG------GUC--AGCGC-------------CGCCGG GACCGGGC---------------------------------------------------- --------------------------------CACUCGGCGG------------------ ------------ACCCCCCCGCCGGCCCCCUCCCCUCGCCGGGAGGGCGGUCGC---GCG GGGGGGA------CGCGGCCC----GGGCGCCCGGCGCCGCG---UUUCCUCCGCGGCGG UGCGCGCGCCGG-CUCCGGGCCGCGUGGGAAGGCCCAGG-------GGUUCAG-GGGAAG GUG-------GCCGGCCGCC---------------------------------------- CCCGCGCGCGGCUACAGCCCCCCCCCAGCAGCAGCACUCGCCGUCGCCCGGGGCCGAGGG AGACG----------------------------------CCGGCCUCCGCGG-------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------UCC-- UCCUCCC-------CGGAGCGCGUCCCGCCGCUCCCCCCC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GGGGGGGCGGCGCGCGGGGCGGGGAAGGGGGAA------------------ --GGGGC------------CCCCCGCUCCCG------GCGCGGCUGUCAACCGGGGCGGA CUGCCCCCAGUGCGCCCCGUCCGCGCCGCGCCG----CCGAGGCGGGAGGGCCGCCGGGA GCCGCCAGGGUCCGCGGCGAUGUCGGUGUCCCACCCGACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----CGCGCGCGCGA---GUCGGA-GGGACU--------CUGCGCGAA-- --------ACCC-U-G-U-GGCGCAAUGAAG-GUGAGGGCCGGGGCGCCCCGGC---UGA GGUGGG-------------------AUCCCGCCGCCCCUCCCUCCGCCCCCCC----GGG GGCGGGGGGGGGGCGCCG------------------------GCGGG------------- ------------------------------------------CCACCACC----GGCCCG UC-U-C----G---CCC-G-------------------CCCCG----------------- --UC--GGGGG-GUGGGCGU---GAGCGCGCGCGAUUAG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGGCAGGC-GAAGCCAGA-GGAAACU-CUGGUGGAGGUCCGU--AGCGGUCCU -GACGUGCAAAUCGGUCGUCCGACCUGG-UAUAGGGGCGAAAGACGAAUCGAACCAUC-U AGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAUAGCUGGCGC-U--------------- -------------------------------GU------------------CCG--U--- ---CGC-------------------AGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUC-U UGG-G-GCC-G--AAA--UCGAUCUCAACCUAUUCUCAAACUUUAAAUGGGUA-AG--A- A---GCC-CGGCUC---GC-UGGCUU-------------------GGAG-C-C----G-- -G-G-G-------------------------------------------------CGUGG -AAU----GC-GGCA-CG--CCAU-AGU-GGG-CCA--CU-UUUGG-UAAGCAGAAC-UG -GCGCUG-CGGGA----UGA--ACCGAACGCCG--GGUUAAG--GCGCC---CGAUGCCG A-C-GC-U-CAU--C-AGA-CCCC--AGA-AAAGGUGUUGGUUGAUAUAGACAGCAGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUAACAACUCACCUGCC-----G AAUCAACUAGCCCUGAAAAUG-GAUGGCGCUG-G-AGCGU---CGG--------GCC--C AUA-CCCGGCC--GUC---G--C----CGGCG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------CUGG--GUCAGUCCGCGGG---------------------- --------------------------GGCUAGGCC-G-CGACUG-A--GUAGGA----GG ---GCCCCG-GCGG-UGG------------------GC-G-------------------- ------------------------------------------------------------ --------------------------------------------------------CGGA AGCGCGC--G--CGA-GG-GCC--CGGG-U-GGA-GCCGCC-G--CGGGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------CGAGAAC----- ----------UUUGAA-GGCC-GAAGUGGAG-AAGGGUUCCA-UGUGAACAGCAGUUGAA CAUGGG------------UCAGUCGG-UC-C-UAA----GAGAUG--GGCGAG--CGCC- ---------------------------G-U-U-CGGAAG---GGA-CG------------ ------------------GGCGAUGGCCUCCGU--------------------------- -----C-----G-CCC-U--C-G-G-----CCGAUC---GA-AA-GGGA-GUC-GGG--U UCA----GAUC-CCC----GAACC-C-GGA---GUGG-C--------------------- -----------------------------------GGAGACGGGCGCCCGCGGCCCCCCC CGACGCCUCGCGGCGGCGGGGGGGCGGGGGCG---------------------------- ----------UCCAGUG--CGGCGACGC-G----A-CCGAUC-CCGG-A-GAA--GCC-G GGGG----AGCCC-GG-GAGA-AGAG------UUCUCUU-------UUC-UUU---GU-- -G------AAG------GG-C-----AG------G--------G---C----CG--CCCU G-A------A----U-G--G--G-----U--UCG-C-CCC-GAGAG-AG--GG----G-C -C-C---GCGCCG--U-UG-G--A-A--A-GCG-UCGC---------------------- ---------GG-UU-----------------------------CCGGC-GGC--GU---C CG-GUGAGCUU---CU-C--G-C-UGGCCCUUGAAA-A-UCCGGGGGAG--AGG------ -----------------------------GUGUAAA------------------------ -U--CUCU-GCG--CC-G-GGCCGUACCCAUAUCCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUGG-CAUGU-UAGA-ACAAUGUA-GGUAAGGGAAGUCGGCAAGU-CAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UA--A-GG-GCUGGGUCGG-UC-GGG-------- ------------------------------------------------------------ --------------------------------------CUGGGGCGCGAAGCGGGGCUGG GCCGC------------------------------------------------------- ---------GCCGCGGC--U--GGA---CG-A-A-GG---C--G--C-C-C-----CCG- -U-GG-C---GCUCUUU----CC--CU-C-CUCCCGCCCC-------------------- ------------------------------------------------------------ -----------------------------------------------------------C CUCU----------------------------------CUCU-CC-GG---CC-C-C-C- CCUCGCGG-GGGG-CC-GC-----G-GGGGC-GG-GGG-------GGCG--------CGG -G-GGGCC---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GGGAGCGCCCGGCGGCGGCGACUC UGGACGCGCGCCGGGCCCUUCCUGUGGAUCGCCCCAGCUGCGGCGCGCGCCUCUCCCCCG CGCCGUCCCCCUCCUGCGCCUCCCCCCGUCAGGGGACGGGGCGCGGCGCGGGGCG----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GCCGG--- -GGCGGG-----------CCCGGCC---------------U-CGG---CCG-G-CGC--- CUAG--CAG-C-UGAC-UUAGAACUGGUGCGGACA--GGGAAUCCGA-----CUGUUUAA UUAAAACAAAGCAUCGCGA-AGGCCC--GA---GGC------------GGGUGU-UG-AC GCGAUGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-UGAAGCGCGG-G-UAAACGG-CGGGAGUAACUAUGACU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUGAACG AG-A--UUCCC--ACUGUCCCUA-CC-UAC-UAUCUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCGGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUCUGCA ACUGUGAAGAGACAUGAGAGGUGUAGGAU-AAGUGGGAGGCCCCCGCGC-------UCGU CGCAAAGG---------------------------------------------------- ----------------------------------GGCG----------------C--CG- CCGG-UGAAAUA-CCACUACUCUUAUCGUUUUUUCACUUA-CCC-G--GUGA--GG--CG GG-----------------------G-G-CG-AGCC--------------CCGAG----- --------GGG-C-U--C-UCGCU------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------UCUGGAC- ------------------------------------------------------------ --------------------------------------------CCAA------------ ----G--CGC---C------------------------GGCCC----CCGCGCC------ ------G---------GGC--GC-------------------GAC-CC-GCUCC-GAGGA -CAG-UGGCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCA-AACCGUAAC-GCAGG UGUCCUAAGGCGAGCUCAGGGAGCACAGAAACCUCCCGUG-GAGCAG-AAGGGCAAAA-G CUCGCUUGAUCU-UGAUUUUC-A---GUAUGAAUACAGACCGUGAAACGCGGGGCCUCAC G-AUCCUUCU-------------------------G--A------CUUUUU-GGG-UU-- ----------------------------UUAAGCAGGAGGUGU-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG-AUGU-------------------------------------------------- ------GUUGUC-GCAAUAGUAA--UCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC AUU-UGGUGUAUGUGCU-UGGCU-GAGG-AGCC-AA--UGGGGCGAAGCUA-CCAUCUGU --G-GGAUUAUGACUGAACGCCUC--U-AAGUCAGAAUCC---CCCCUA-AACGUGA--- -----CGAU---------------------------AC--CGCAGCG----CC-G--C-- G--GAG-C-CUC------------------------------------------------ ---------------------------------------GG-UCGGCCUCG--------- ----GAUUA---GC--CGGCGCCCCCCCCG---------------------GGGGGCGCC GGCGGGCAGAGCC-------------GCUCGCCU-------------------------- -----------CGGGACCGGAGCGCGGAC------------------------------- -------------------GAAAGGGG-----GCCGCC-UCUCUCC---CG--GAG---- CGCACC------------------------------------------------------ ----------------------------------------GCACGUUCGUG--------- -GGGAACCU-GGUG-----CUAAAUC----AUUC--G-UAGACGACCU-GA-UUCUGGGU CAGGGUUUCGUGCG-UAGCAGAGCAGCUACC--------------UCGCU--GC-----G -AUCUAU--U--GAAAGUCAU-CCCUU---G-GC-C-A-AGC------------------ -------- >Yarrowia_lipolytica ----------------AUAACUAUCAAC-AACGGAUC-UCU-UGGCU-CUC-A--CAU-C GAUGAAGAACGCAGC-GAACCGCGAUAUUUU-UUGUGACUUGCAGAU-----G-U-GAAU CAUC-AAUCUUUGAACGCACAU-UGCGCGGUAUGGCAUU--------------------- -----------CCGUAC------------------CGCA--------------------- -------------------------------------------------------CGG-A UGGAGGAGCGUGUU---------------------------------------------- -------UUCACCUCCUUCA-UCCGAGAUU-ACCCGCUGAACUUAAGCAUAUCAAUAAGC --GGAGGAAAAGAAACCAACAGGGAUUGCCUCA-GU-AAC-GGCGAGUGAAGCGGCAAA- AGCUCAAAUUUGAAACCC---------------------UCGGGAUUGUAAUUUGA---- ----------------------------AGAUUUGGC----------------------- ------------A------UUG--GAG------AAAGCUAA------CCC-AAGUU-GCU UG-GA-------AUAGU------A-CGUC-AUAGAGGGUGACAACCCCGUCUGGCUAAC- -C-----GU---------UCUCCA-UGUAUUGCCUUAUCAAAGAGUCGAGUUGUUU---G GGAAUGCAGCUCAAAG-UGGGUGGUAAACUCCAUCUAAAGCUAAAUACUGG-UG-AGAGA CCGAUAGC-GAA-CAAGUACUGUGAAGGAAAGGUGAAA-AGAAC-UUUGAAAAGAG-AGU GAAAUAGUAUGUGAAAUUGUUGAUAGG---G-AAG-G-AAAUGAGUGGAGAG------UG G---CCG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---AGGUUUCAGCCGC-------------------------C-C-CUCGUGGGCGGUGUA CUGC-------------------------------------------------------- --------------------CGACGCCGAGUCAU-----------------CGAUAGC-- --GAGACGAG-GGU-UA-------------CAAAUG--GGA-----GCGCCUU------U CGGG--CG-UUCUCCCCU-AACCCUCCACACU----------------------GCCACC GACGAC---AUAAUCC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ACCCAUUUCACCCGUCUUGAAACACGGACCAA GGAGUCUA-A----UGGAUAUGUGA---GUGUUA-GGG--U-----------GGCAA--- --------ACCC-C-A-G-CGCGCAAUGAAA-GUGAAUG--------------------- ---------------------------------------------------------GAU UC----------------------------------------GUUC-------------- --------------------------------------------AGAAUC----GACCGA AC-U-U----G---AUU-----------------------AUU----------------- --AU--GACAG-UUUUGAGU-AA---ACACAUCCAUUGG-GACCCGAAAGAUG-GUGAAC UAUGCCUGGAUAGGGUGAAGUCAGA-GGAAACU-CUGAUGGAGGCUCGU--AGCGGUUCU -GACGUGCAAAUCGAUCGUAGGAUCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUC-U AGUAGCUGGUUCCUGCCGAAGUUUCCCUCAGGAUAGCAGAAGC-U--------------- --------------------------------------------------CAUA--UC-- -------------------------AGUUUUAUGAGGUAAAGCGAAUGAUUAGAAGUA-U UGG-G-GGC-G--AAA--UGCCCU-CGGCUUAUUCUCAAACUUUAAAUAUGUA-AG--A- A---GCC-UUGGUU---AC-UUAAUC-------------------GAAC-C-G----U-- -G-G-C--------------------------------------------------UACG -AAU----GAA--GA--G-CUUCU-AGU-GGG-CCA--UU-UUUGG-UAAGCAGAAC-UG -GCGAUG-CGGGA----UGA--ACCGAACGUGG--AGUUAAG--GUGCC--GGAAUA--C A-C-GC-U-CAU--C-AGA-CACC--ACA-AAAGGUGUUAGUUUAUCUAGACAGCCGGAC GGUGGCCAUGG-AAGUCGGAAU-CCGCUAAGGAGUGUGUCACAACUCACCGGCC-----G AAUGAACUAGCCCUGAAAAUG-GAUGGCGCUU-A-AGCGU---GUU--------ACC--U AUA-CUCUACC--GAG---A--G----GA-G----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------G-U-------------------------- -------------------------------UUCC-U-C-U-CG-A--GUAGGC----AG ---G-CGUG-GGGG-UUG------------------UU-G-------------------- ------------------------------------------------------------ --------------------------------------------------------AG-A AGCGUUG--G-CCGA-GA-AGC--UGCG-U-CGA-ACGGCC-C--CUAGUGCAGAUCU-U GGUGG-UAGUA-GCA-A--AU-AUUCAA-A------------------UGAGAAC----- ----------UUUGAA-GACU-GAAGUGGGG-AAAGGUUCCG-UGUGAACAGCAGUUGGA CACGGG------------UAAGUCGA-UC-C-UAA----GGGGUG--GCAUAA--CUG-- -----------------------------------UCGC---GUA-CGG-C--------- ---------------------------CCGA----------------------------- -----------UA-AG-G--G-C-C-----UUCUCC---AA-AA-GGGA-AGC-CGG--U UGA----AAUU-CCG----GCACU-U-GGAU--GUGG-A-UUCUC--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------C-A--CGGCAACGU-A----A-CUGAAU-GUGG-G-GA-CGGUG-G CACA----AGUCU-UG-GA-A-GGAG------UUAUCUU-------UUC-UUU---UU-- -A------ACGG-----AG-U------C------A--------A---C-----A--CCCU G-G------A---AU-U--A--G-----U--UUG-U-CUA-GAGAU-AG--GG----U-A -U-C---GU-U-C--C--G-G--A-AG-A-GGG-GGGCA--------------------- ---------GC-UU-----------------------------U--GU-CCC--CU---C CG-AUGCACU----UG-U--G-A-CGCCCCUUGAAA-A-CCCGCAGGAA--GGA------ -----------------------------AUAG--------------------------- -U--UUUC-ACG--CC-A-AGUCGUACUGAUAACCGCAGCAGGUCUCCA-AGG-UGAACA -G-CCUCUAG-UU-GA-UAGA-AUAAUGUA-GAUAAGGGAAGUCGGCAAAA-UAGAUCCG UAACUUCGGG-AUAAGGAUUGGCUC-UG--G-GG-GUUG-GU-GG--A-UGG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AA-G-C-GU---G-----G-G-A--GA-CCC- -C--A-A---G-GGA-C-U--GG--CA-G-C-U-GG------------------------ ------------------------------------------------------------ -----------------------------------------------------------G ---------------------------------------------------CA-A-C-U- G-GC-AGC-CGGA-CC-C------G-C---G-G--CAG------AC-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------A------------------------------- ----------------CUGC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------G--UCGC-U----------------C-CGU----CC-A-CAU--- -CAU--CAA-C-CGCC-CCAGAACUGGUACGGACAAGGGGAAUCUGA-----CUGUCUAA UUAAAACAUAGCUUUGCGA-UGGUUG--UA---AAA------------CAAUGU-UG-AC GCAAAGUG-AUUUCUGCCCAGUGCUC-UGAAUGUCAAA-GUGAA-------------GAA A---------------UUCAA-CCAAGCGCGCGGGUAAACGG-CGGGAGUAACUAUG-CU CUCUUAAGGUAGCCAAAUGCCUCGUCAUC-UAAUUAGUGACGCGCAUGAAUGGAUUAACG AG-A--UUCCC--ACUGUCCCUA-UC-UAC-UAUGUAGCGAAACCACAG--CCAAGGGAA CGGGCUUGGCAGAAUCAGCGGGGAAAGAAGA-CCCUGUUGAGC-UUGACUCUAGUUUGAC AUUGUGAAGAGACAUAGGGGGUGUAGAAU-AAGUGGGAG-C------------------- ------------------------------------------------------------ ----------------------------------UUCG----------------G--CG- CCGG-UGAAAUA-CCACUACCCUUAUCGUUUCUUUACUUA-------------------- -----------------------------------UU--------------UAGU----- --------AAG-U-G--GAA--GU------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GGUUUAA ------------------------------------------------------------ --------------------------------------------CAAC------------ ----C--AUU---U--U---------------------CUAGC----------------- ----------------AUU--CC-------------------UUU-CC-AGGCU-GAAGA -CAU-UGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUA-AAAGAUAAC-GCAGA UGUCCUAAGGGGGACUCAAUGAGAACAGAAAUCUCAUGUA-GAACAA-AAGGGUAAAA-G UCCCCUUGAUUU-UGAUUUUC-A---GUGUGAAUACAAACCAUGAAAGUGUGGCCU-AUC G-AUCCUUUA-------------------------G--U------UGUUCG-GAG-UU-- ----------------------------UGAACCUAGAGGUGC-CAG--AAAAGUUACCA CAGGGA-UAACUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUCCUUC GAUGUCGGCUCUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCA CUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUG --AUG-GA-C-------------------------------------------------- -------UUGUU-GCAAUAGUAA--UUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAU AAU-UGGUGUUUGCUGC-UGUCU-GACC-AGGC-AA--UGCAGCGAAGC-A-CCACCCGC --U-GGGUUAUGGCCGAACGCCUC--C-AAGUCAGAACCC------AUG-CCA--GA--- --AGGGAAG---------------------------AA--U------C------------ ---------AGG------------------------------------------------ ---------------------------------------GG-GAAGGAGGG--------- ---AUAUGA---AG--AAGU---------------------------------------- --------------------------ACCGC----------------------------- -----------------------AGUAC-C--GGAGGGGGAGGGGGG-GU-GGAU--A-A GGAAA-C-------C-------GC--------------------CC----G--CC--CC- C-CCCC------------------------------------------------------ --------------------------------------GACUGGAAAGACCC-------- -ACCCUUGU-GA----------AAUC----CAUU--G-UAGACGACUU-UA-GUAUGCGA CGAGGUAUUGUAAG-UA--GUAGAGUAGC-C--------------UUGUU--GUUAC--G -AUCUAU--U--GAGAUUAAG--CCUU---U-GUUGUUU-AGAUUC-GA----------- --------