Gating-Pore Currents Demonstrate Selective and Specific Modulation of Individual Sodium Channel Voltage-Sensors by Biological Toxins

Data Supplement

Files in this Data Supplement:

  • Supplemental Figures -

    Supplemental Figure 1 - No gating pore current (Igp) was generated by WT* Nav1.5 expressed in HEK293 cells

    Supplemental Figure 2 - Gd3+ inhibited inward Igp fluxing through hNav1.5 DI - DIV voltage sensor mutants

    Supplementary Figure 3 - Modification of DIV gating pore currents by ApB was not altered in the presence (A) or absence (B) of TTX

    Supplemental Figure 4 - ProTx-II modulates inward Igp generated by DIV VSD mutations in hNav1.7

    Supplemental Figure 5 - Double Gly-mutations of the 3rd and 4th gating-charge residues in Nav1.5 DI and DII voltage sensors produced outward Igp in HEK293 cells

    Supplemental Figure 6 - Gd3+ inhibited the outward Igp fluxing through hNav1.5 DI (A) and DII (B) voltage sensor mutants

    Supplemental Figure 7 - Effect of the HWTX-IV + ApB mixture on inward Igp generated by hNav1.5 DI voltage sensor mutant (R1G/R2G)