Chromatinized Protein Kinase C-θ Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells

Supplemental material

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• Supplemental file 1 -

  Fig. S1 (CSC population upon PKC pathway induction), S2 (Validation of PKC-θ knockdown by PKC-θ siRNA and shRNA), S3 (Knockdown of PKC-θ and chromatin association), S4 (PKC-θ activity inhibition and CD44^high CD24^low CSC formation), S5 (PKC-θ regulation of p65 and p50 activity), S6 (Validation of p50 and p65 protein knockdown), S7 (ChIP-seq comparison), S8 (Validation of PKC-θ ChIP-seq analysis), and S9 (Dual roles for PKC-θ signaling and chromatin regulation) and legends to Tables S1 to S6

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• Supplemental file 2 -

  Tables S1 (MCF-IM-inducible gene expression microarray profile), S2 and S3 (GSEA reports), S4 (PKC-driven inducible genes sensitive to the PKC-θ pathway), S5 (PKC-θ binding regions and gene expression microarray analysis), and S6 (Overrepresented transcription factor motifs)

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