GO Term Description P-value FDR q-value Enrichment N B n b Genes GO:0048522 positive regulation of cellular process 2.17E-14 1.34E-10 1.65 16376 3497 548 193 "[CREB5 - camp responsive element binding protein 5, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, TSPAN14 - tetraspanin 14, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), LIFR - leukemia inhibitory factor receptor alpha, RFX3 - regulatory factor x, 3 (influences hla class ii expression), GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, KLF5 - kruppel-like factor 5 (intestinal), CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, MYO10 - myosin x, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, EPS8L1 - eps8-like 1, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADCY8 - adenylate cyclase 8 (brain), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, HES5 - hairy and enhancer of split 5 (drosophila), CAPN3 - calpain 3, (p94), SYT1 - synaptotagmin i, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, UVRAG - uv radiation resistance associated, ACKR3 - atypical chemokine receptor 3, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2, GAS1 - growth arrest-specific 1, PAIP1 - poly(a) binding protein interacting protein 1, PAX6 - paired box 6, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, APC - adenomatous polyposis coli, PIAS1 - protein inhibitor of activated stat, 1, DFNA5 - deafness, autosomal dominant 5, TMEM27 - transmembrane protein 27, CYTL1 - cytokine-like 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, HAS2 - hyaluronan synthase 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, ZEB2 - zinc finger e-box binding homeobox 2, FAM175A - family with sequence similarity 175, member a, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, SULF2 - sulfatase 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), TSPAN31 - tetraspanin 31, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), FBN2 - fibrillin 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, PTX3 - pentraxin 3, long, ANKRD6 - ankyrin repeat domain 6, NOTCH4 - notch 4, CHN2 - chimerin 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FOXP2 - forkhead box p2, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, NID1 - nidogen 1, SMOC1 - sparc related modular calcium binding 1, TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, FNDC5 - fibronectin type iii domain containing 5, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SH3BGRL - sh3 domain binding glutamic acid-rich protein like]" GO:0044767 single-organism developmental process 5.80E-14 2.39E-10 1.61 16376 3683 548 199 "[CREB5 - camp responsive element binding protein 5, MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, LGALS8 - lectin, galactoside-binding, soluble, 8, TSHZ2 - teashirt zinc finger homeobox 2, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, KLF5 - kruppel-like factor 5 (intestinal), APCDD1 - adenomatosis polyposis coli down-regulated 1, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, CPE - carboxypeptidase e, PLXNA2 - plexin a2, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), HES4 - hairy and enhancer of split 4 (drosophila), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, PLCD1 - phospholipase c, delta 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, PPL - periplakin, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, TP53INP2 - tumor protein p53 inducible nuclear protein 2, GPSM2 - g-protein signaling modulator 2, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), COL9A3 - collagen, type ix, alpha 3, RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), BCL10 - b-cell cll/lymphoma 10, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), FREM2 - fras1 related extracellular matrix protein 2, ARID5B - at rich interactive domain 5b (mrf1-like), ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, NRARP - notch-regulated ankyrin repeat protein, ZBTB18 - zinc finger and btb domain containing 18, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, ACKR3 - atypical chemokine receptor 3, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CRYBA1 - crystallin, beta a1, CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RUNX3 - runt-related transcription factor 3, EPHB1 - eph receptor b1, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, FN1 - fibronectin 1, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, DCX - doublecortin, PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, CECR1 - cat eye syndrome chromosome region, candidate 1, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8, ERRFI1 - erbb receptor feedback inhibitor 1, DFNA5 - deafness, autosomal dominant 5, CYTL1 - cytokine-like 1, MSI2 - musashi rna-binding protein 2, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, KIAA1161 - kiaa1161, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, HAS2 - hyaluronan synthase 2, ATL1 - atlastin gtpase 1, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAT4 - fat atypical cadherin 4, CLIP3 - cap-gly domain containing linker protein 3, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, SAT1 - spermidine/spermine n1-acetyltransferase 1, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), SATB1 - satb homeobox 1, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), SHISA3 - shisa family member 3, FBN2 - fibrillin 2, ZFAND5 - zinc finger, an1-type domain 5, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CRB1 - crumbs homolog 1 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, FAM65B - family with sequence similarity 65, member b, SP8 - sp8 transcription factor, FOXP2 - forkhead box p2, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, DUSP1 - dual specificity phosphatase 1, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), MAP7 - microtubule-associated protein 7, SMOC1 - sparc related modular calcium binding 1, CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RBM24 - rna binding motif protein 24, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, SEZ6L - seizure related 6 homolog (mouse)-like, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, TRIM45 - tripartite motif containing 45, TGIF1 - tgfb-induced factor homeobox 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, BCHE - butyrylcholinesterase, PCDH18 - protocadherin 18]" GO:0048518 positive regulation of biological process 1.98E-14 2.45E-10 1.6 16376 3900 548 209 "[CREB5 - camp responsive element binding protein 5, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), LIFR - leukemia inhibitory factor receptor alpha, RFX3 - regulatory factor x, 3 (influences hla class ii expression), GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, KLF5 - kruppel-like factor 5 (intestinal), CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, MYO10 - myosin x, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, EPS8L1 - eps8-like 1, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADCY8 - adenylate cyclase 8 (brain), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, HES5 - hairy and enhancer of split 5 (drosophila), CAPN3 - calpain 3, (p94), SYT1 - synaptotagmin i, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, CTSK - cathepsin k, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, ACKR3 - atypical chemokine receptor 3, UVRAG - uv radiation resistance associated, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), POLR3GL - polymerase (rna) iii (dna directed) polypeptide g (32kd)-like, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), BOC - boc cell adhesion associated, oncogene regulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, PAIP1 - poly(a) binding protein interacting protein 1, PAX6 - paired box 6, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, APC - adenomatous polyposis coli, PIAS1 - protein inhibitor of activated stat, 1, DFNA5 - deafness, autosomal dominant 5, TMEM27 - transmembrane protein 27, CYTL1 - cytokine-like 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, HAS2 - hyaluronan synthase 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAM175A - family with sequence similarity 175, member a, DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, S100A10 - s100 calcium binding protein a10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, TSPAN31 - tetraspanin 31, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), FBN2 - fibrillin 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, PTX3 - pentraxin 3, long, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, NOTCH4 - notch 4, CHN2 - chimerin 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FOXP2 - forkhead box p2, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, IFIH1 - interferon induced with helicase c domain 1, NID1 - nidogen 1, HBP1 - hmg-box transcription factor 1, SMOC1 - sparc related modular calcium binding 1, TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, FNDC5 - fibronectin type iii domain containing 5, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, SH3BGRL - sh3 domain binding glutamic acid-rich protein like]" GO:0032502 developmental process 8.36E-14 2.59E-10 1.57 16376 4082 548 214 "[CREB5 - camp responsive element binding protein 5, A2M - alpha-2-macroglobulin, MEX3C - mex-3 rna binding family member c, TAGLN3 - transgelin 3, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, TSHZ2 - teashirt zinc finger homeobox 2, LGALS8 - lectin, galactoside-binding, soluble, 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, KLF5 - kruppel-like factor 5 (intestinal), APCDD1 - adenomatosis polyposis coli down-regulated 1, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, CPE - carboxypeptidase e, PLXNA2 - plexin a2, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), HES4 - hairy and enhancer of split 4 (drosophila), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, MINPP1 - multiple inositol-polyphosphate phosphatase 1, PLCD1 - phospholipase c, delta 1, BMP7 - bone morphogenetic protein 7, IGSF8 - immunoglobulin superfamily, member 8, ACVR2A - activin a receptor, type iia, PPL - periplakin, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, TP53INP2 - tumor protein p53 inducible nuclear protein 2, GPSM2 - g-protein signaling modulator 2, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), COL9A3 - collagen, type ix, alpha 3, RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), BCL10 - b-cell cll/lymphoma 10, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), FREM2 - fras1 related extracellular matrix protein 2, ARID5B - at rich interactive domain 5b (mrf1-like), ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, NRARP - notch-regulated ankyrin repeat protein, ZBTB18 - zinc finger and btb domain containing 18, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, ACKR3 - atypical chemokine receptor 3, ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CRYBA1 - crystallin, beta a1, CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RUNX3 - runt-related transcription factor 3, EPHB1 - eph receptor b1, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, FN1 - fibronectin 1, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, DCX - doublecortin, PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CECR1 - cat eye syndrome chromosome region, candidate 1, PCDH8 - protocadherin 8, ERRFI1 - erbb receptor feedback inhibitor 1, DFNA5 - deafness, autosomal dominant 5, CYTL1 - cytokine-like 1, MSI2 - musashi rna-binding protein 2, MOBP - myelin-associated oligodendrocyte basic protein, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, KIAA1161 - kiaa1161, PTCH1 - patched 1, RNF103 - ring finger protein 103, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, HAS2 - hyaluronan synthase 2, GPC4 - glypican 4, ATL1 - atlastin gtpase 1, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAT4 - fat atypical cadherin 4, CLIP3 - cap-gly domain containing linker protein 3, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, SAT1 - spermidine/spermine n1-acetyltransferase 1, DACH1 - dachshund homolog 1 (drosophila), CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), SATB1 - satb homeobox 1, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), SHISA3 - shisa family member 3, FBN2 - fibrillin 2, ZFAND5 - zinc finger, an1-type domain 5, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CRB1 - crumbs homolog 1 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, FAM65B - family with sequence similarity 65, member b, SP8 - sp8 transcription factor, FOXP2 - forkhead box p2, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, DUSP1 - dual specificity phosphatase 1, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), PCDHB2 - protocadherin beta 2, MAP7 - microtubule-associated protein 7, LSAMP - limbic system-associated membrane protein, SMOC1 - sparc related modular calcium binding 1, CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RBM24 - rna binding motif protein 24, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, SCRG1 - stimulator of chondrogenesis 1, SEZ6L - seizure related 6 homolog (mouse)-like, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, TRIM45 - tripartite motif containing 45, TGIF1 - tgfb-induced factor homeobox 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, BCHE - butyrylcholinesterase, PCDH18 - protocadherin 18, SH3GL2 - sh3-domain grb2-like 2]" GO:0045595 regulation of cell differentiation 1.14E-12 2.82E-09 2.22 16376 1172 548 87 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, MEX3C - mex-3 rna binding family member c, TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAPN3 - calpain 3, (p94), RUFY3 - run and fyve domain containing 3, PAX6 - paired box 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, BTG1 - b-cell translocation gene 1, anti-proliferative, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, APOLD1 - apolipoprotein l domain containing 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, FYN - fyn oncogene related to src, fgr, yes, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, SMOC1 - sparc related modular calcium binding 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, JUND - jun d proto-oncogene, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, FNDC5 - fibronectin type iii domain containing 5, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ADA - adenosine deaminase, MAP2K6 - mitogen-activated protein kinase kinase 6, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, RBM24 - rna binding motif protein 24, ITPKB - inositol-trisphosphate 3-kinase b, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, INSM1 - insulinoma-associated 1, ZEB2 - zinc finger e-box binding homeobox 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, S100A10 - s100 calcium binding protein a10, BAMBI - bmp and activin membrane-bound inhibitor, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF13 - kruppel-like factor 13, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, FBN2 - fibrillin 2, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0048869 cellular developmental process 5.58E-12 9.87E-09 1.82 16376 2085 548 127 "[CREB5 - camp responsive element binding protein 5, A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, FN1 - fibronectin 1, LGALS8 - lectin, galactoside-binding, soluble, 8, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, RFX3 - regulatory factor x, 3 (influences hla class ii expression), DCX - doublecortin, BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, GAB2 - grb2-associated binding protein 2, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, KLF5 - kruppel-like factor 5 (intestinal), PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, CYTL1 - cytokine-like 1, HES4 - hairy and enhancer of split 4 (drosophila), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), ELF1 - e74-like factor 1 (ets domain transcription factor), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, MSI2 - musashi rna-binding protein 2, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, KIAA1161 - kiaa1161, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADA - adenosine deaminase, GPSM2 - g-protein signaling modulator 2, ATL1 - atlastin gtpase 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), S100A6 - s100 calcium binding protein a6, SOX6 - sry (sex determining region y)-box 6, FAT4 - fat atypical cadherin 4, CLIP3 - cap-gly domain containing linker protein 3, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, KLF6 - kruppel-like factor 6, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), SATB1 - satb homeobox 1, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CRB1 - crumbs homolog 1 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, ARID5B - at rich interactive domain 5b (mrf1-like), CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2 - microtubule-associated protein 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, FAM65B - family with sequence similarity 65, member b, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), OSR2 - odd-skipped related 2 (drosophila), FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, KLF15 - kruppel-like factor 15, SMOC1 - sparc related modular calcium binding 1, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, CD9 - cd9 molecule, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, RBM24 - rna binding motif protein 24, TPP1 - tripeptidyl peptidase i, RUNX3 - runt-related transcription factor 3, TGFBR1 - transforming growth factor, beta receptor 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, EPHA4 - eph receptor a4, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, ANXA1 - annexin a1, BCHE - butyrylcholinesterase, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:0050896 response to stimulus 5.17E-12 1.07E-08 1.38 16376 6026 548 279 "[A2M - alpha-2-macroglobulin, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, REV3L - rev3-like, polymerase (dna directed), zeta, catalytic subunit, CAB39L - calcium binding protein 39-like, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RGR - retinal g protein coupled receptor, LIFR - leukemia inhibitory factor receptor alpha, OS9 - osteosarcoma amplified 9, endoplasmic reticulum lectin, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, NCAM1 - neural cell adhesion molecule 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, KSR1 - kinase suppressor of ras 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, PLOD2 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, CPE - carboxypeptidase e, PLXNA2 - plexin a2, EPS8L1 - eps8-like 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, PLCD1 - phospholipase c, delta 1, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, BMP7 - bone morphogenetic protein 7, STK38L - serine/threonine kinase 38 like, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, ADA - adenosine deaminase, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), AMOTL2 - angiomotin like 2, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), HIST3H2A - histone cluster 3, h2a, RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SLIT1 - slit homolog 1 (drosophila), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, BCL10 - b-cell cll/lymphoma 10, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, GMPR - guanosine monophosphate reductase, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), CAPS - calcyphosine, TTC21B - tetratricopeptide repeat domain 21b, MTTP - microsomal triglyceride transfer protein, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), SYT1 - synaptotagmin i, ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), RAD54B - rad54 homolog b (s. cerevisiae), INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, UVRAG - uv radiation resistance associated, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MICU1 - mitochondrial calcium uptake 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), POLR3GL - polymerase (rna) iii (dna directed) polypeptide g (32kd)-like, CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, GAD1 - glutamate decarboxylase 1 (brain, 67kda), MAPK10 - mitogen-activated protein kinase 10, ACSBG1 - acyl-coa synthetase bubblegum family member 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, AMPH - amphiphysin, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), BOC - boc cell adhesion associated, oncogene regulated, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, SPON2 - spondin 2, extracellular matrix protein, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, FN1 - fibronectin 1, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, GAB2 - grb2-associated binding protein 2, VEZF1 - vascular endothelial zinc finger 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, TP53TG1 - tp53 target 1 (non-protein coding), APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, CYTL1 - cytokine-like 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, DUSP10 - dual specificity phosphatase 10, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, GPC4 - glypican 4, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, GPR162 - g protein-coupled receptor 162, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, SPATA18 - spermatogenesis associated 18, S100A6 - s100 calcium binding protein a6, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, S100A10 - s100 calcium binding protein a10, DAPK1 - death-associated protein kinase 1, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), PTPRD - protein tyrosine phosphatase, receptor type, d, ARHGAP9 - rho gtpase activating protein 9, ZFAND5 - zinc finger, an1-type domain 5, MGST2 - microsomal glutathione s-transferase 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP4 - timp metallopeptidase inhibitor 4, HIST2H2BE - histone cluster 2, h2be, EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, NOVA1 - neuro-oncological ventral antigen 1, CHN2 - chimerin 2, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, ABCB4 - atp-binding cassette, sub-family b (mdr/tap), member 4, CHL1 - cell adhesion molecule l1-like, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, WSB1 - wd repeat and socs box containing 1, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, FOXP2 - forkhead box p2, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, HBP1 - hmg-box transcription factor 1, MAP7 - microtubule-associated protein 7, SMOC1 - sparc related modular calcium binding 1, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, FNDC5 - fibronectin type iii domain containing 5, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SPARCL1 - sparc-like 1 (hevin), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ZFYVE26 - zinc finger, fyve domain containing 26, RASD1 - ras, dexamethasone-induced 1, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, SGK1 - serum/glucocorticoid regulated kinase 1, BCHE - butyrylcholinesterase, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, SH3GL2 - sh3-domain grb2-like 2]" GO:0048856 anatomical structure development 3.37E-11 5.22E-08 1.7 16376 2472 548 141 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, PAX6 - paired box 6, GSN - gelsolin, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), DCX - doublecortin, PBX1 - pre-b-cell leukemia homeobox 1, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, EN1 - engrailed homeobox 1, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, PLP1 - proteolipid protein 1, EGR3 - early growth response 3, PLXNA2 - plexin a2, BIK - bcl2-interacting killer (apoptosis-inducing), CYTL1 - cytokine-like 1, HES4 - hairy and enhancer of split 4 (drosophila), MINPP1 - multiple inositol-polyphosphate phosphatase 1, PLCD1 - phospholipase c, delta 1, MOBP - myelin-associated oligodendrocyte basic protein, MSI2 - musashi rna-binding protein 2, BMP7 - bone morphogenetic protein 7, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, IGSF8 - immunoglobulin superfamily, member 8, KIAA1161 - kiaa1161, RNF103 - ring finger protein 103, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, COL9A3 - collagen, type ix, alpha 3, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAT4 - fat atypical cadherin 4, SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), SATB1 - satb homeobox 1, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ZFAND5 - zinc finger, an1-type domain 5, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CRB1 - crumbs homolog 1 (drosophila), CAPN3 - calpain 3, (p94), TIMP4 - timp metallopeptidase inhibitor 4, FREM2 - fras1 related extracellular matrix protein 2, ARID5B - at rich interactive domain 5b (mrf1-like), ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, FAM65B - family with sequence similarity 65, member b, ZBTB18 - zinc finger and btb domain containing 18, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, NKX6-1 - nk6 homeobox 1, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), PCDHB2 - protocadherin beta 2, OSR2 - odd-skipped related 2 (drosophila), FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, LSAMP - limbic system-associated membrane protein, SMOC1 - sparc related modular calcium binding 1, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), CRYBA1 - crystallin, beta a1, DLL3 - delta-like 3 (drosophila), CCNG1 - cyclin g1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, TPP1 - tripeptidyl peptidase i, RUNX3 - runt-related transcription factor 3, TGFBR1 - transforming growth factor, beta receptor 1, SCRG1 - stimulator of chondrogenesis 1, SEZ6L - seizure related 6 homolog (mouse)-like, TRIM45 - tripartite motif containing 45, EPHB1 - eph receptor b1, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, VCAN - versican, GAS1 - growth arrest-specific 1, PCDH18 - protocadherin 18, SH3GL2 - sh3-domain grb2-like 2]" GO:0050793 regulation of developmental process 5.77E-11 7.94E-08 1.91 16376 1631 548 104 "[MEX3C - mex-3 rna binding family member c, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, FN1 - fibronectin 1, PAX6 - paired box 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, MYO10 - myosin x, APOLD1 - apolipoprotein l domain containing 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SLIT1 - slit homolog 1 (drosophila), SOX6 - sry (sex determining region y)-box 6, S100A10 - s100 calcium binding protein a10, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, FBN2 - fibrillin 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), RUFY3 - run and fyve domain containing 3, CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), FYN - fyn oncogene related to src, fgr, yes, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SMOC1 - sparc related modular calcium binding 1, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, FNDC5 - fibronectin type iii domain containing 5, LRP6 - low density lipoprotein receptor-related protein 6, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, RBM24 - rna binding motif protein 24, ITPKB - inositol-trisphosphate 3-kinase b, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0010628 positive regulation of gene expression 8.75E-11 1.08E-07 2.09 16376 1187 548 83 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CAPN3 - calpain 3, (p94), PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, PLP1 - proteolipid protein 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KAT6B - k(lysine) acetyltransferase 6b, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0045893 "positive regulation of transcription, DNA-templated" 1.24E-10 1.28E-07 2.14 16376 1091 548 78 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CAPN3 - calpain 3, (p94), PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0030154 cell differentiation 1.14E-10 1.29E-07 1.96 16376 1451 548 95 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, LGALS8 - lectin, galactoside-binding, soluble, 8, F11R - f11 receptor, PAX6 - paired box 6, ARID5B - at rich interactive domain 5b (mrf1-like), CTGF - connective tissue growth factor, NOTCH4 - notch 4, BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, GAB2 - grb2-associated binding protein 2, JAG1 - jagged 1, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, EID2B - ep300 interacting inhibitor of differentiation 2b, DFNA5 - deafness, autosomal dominant 5, GADD45G - growth arrest and dna-damage-inducible, gamma, FAM65B - family with sequence similarity 65, member b, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), HES4 - hairy and enhancer of split 4 (drosophila), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, KLF15 - kruppel-like factor 15, SMOC1 - sparc related modular calcium binding 1, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, TP53INP2 - tumor protein p53 inducible nuclear protein 2, GPSM2 - g-protein signaling modulator 2, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, RBM24 - rna binding motif protein 24, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, INSM1 - insulinoma-associated 1, EPHB1 - eph receptor b1, FAT4 - fat atypical cadherin 4, SOX6 - sry (sex determining region y)-box 6, CLIP3 - cap-gly domain containing linker protein 3, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, KLF6 - kruppel-like factor 6, ANXA1 - annexin a1, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, BCHE - butyrylcholinesterase, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0050794 regulation of cellular process 1.65E-10 1.46E-07 1.26 16376 8390 548 353 "[CREB5 - camp responsive element binding protein 5, MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, CAB39L - calcium binding protein 39-like, TSHZ2 - teashirt zinc finger homeobox 2, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RGR - retinal g protein coupled receptor, RFX4 - regulatory factor x, 4 (influences hla class ii expression), LIFR - leukemia inhibitory factor receptor alpha, RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PNRC1 - proline-rich nuclear receptor coactivator 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, NCAM1 - neural cell adhesion molecule 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, KSR1 - kinase suppressor of ras 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, CPE - carboxypeptidase e, PLXNA2 - plexin a2, EPS8L1 - eps8-like 1, PIFO - primary cilia formation, BIK - bcl2-interacting killer (apoptosis-inducing), ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, PLCD1 - phospholipase c, delta 1, DOCK10 - dedicator of cytokinesis 10, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, CCNDBP1 - cyclin d-type binding-protein 1, STK38L - serine/threonine kinase 38 like, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADA - adenosine deaminase, PTBP2 - polypyrimidine tract binding protein 2, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), AMOTL2 - angiomotin like 2, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), CAPS - calcyphosine, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), CAPG - capping protein (actin filament), gelsolin-like, ARID5B - at rich interactive domain 5b (mrf1-like), SYT1 - synaptotagmin i, ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, BEX2 - brain expressed x-linked 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, UVRAG - uv radiation resistance associated, CRIPT - cysteine-rich pdz-binding protein, CCNL1 - cyclin l1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG2 - cyclin g2, CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), BOC - boc cell adhesion associated, oncogene regulated, CRBN - cereblon, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, ZNF846 - zinc finger protein 846, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, PAIP1 - poly(a) binding protein interacting protein 1, FN1 - fibronectin 1, ZNF638 - zinc finger protein 638, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), IGFBPL1 - insulin-like growth factor binding protein-like 1, DCX - doublecortin, STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, DFNA5 - deafness, autosomal dominant 5, TMEM27 - transmembrane protein 27, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, DUSP10 - dual specificity phosphatase 10, C1orf85 - chromosome 1 open reading frame 85, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, SCN3A - sodium channel, voltage-gated, type iii, alpha subunit, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, CLIC6 - chloride intracellular channel 6, FAM107A - family with sequence similarity 107, member a, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, GPC4 - glypican 4, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, GPR162 - g protein-coupled receptor 162, IL31RA - interleukin 31 receptor a, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, TBC1D8 - tbc1 domain family, member 8 (with gram domain), CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, TSPAN31 - tetraspanin 31, SAT1 - spermidine/spermine n1-acetyltransferase 1, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, ZFAND5 - zinc finger, an1-type domain 5, FBN2 - fibrillin 2, KAT7 - k(lysine) acetyltransferase 7, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP2 - timp metallopeptidase inhibitor 2, EPC2 - enhancer of polycomb homolog 2 (drosophila), RUFY3 - run and fyve domain containing 3, PTX3 - pentraxin 3, long, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, PILRB - paired immunoglobin-like type 2 receptor beta, CHL1 - cell adhesion molecule l1-like, DOCK6 - dedicator of cytokinesis 6, WSB1 - wd repeat and socs box containing 1, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, NID1 - nidogen 1, HBP1 - hmg-box transcription factor 1, SMOC1 - sparc related modular calcium binding 1, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, FNDC5 - fibronectin type iii domain containing 5, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SPARCL1 - sparc-like 1 (hevin), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, RBM24 - rna binding motif protein 24, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, SNCAIP - synuclein, alpha interacting protein, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, BCHE - butyrylcholinesterase, NECAB3 - n-terminal ef-hand calcium binding protein 3, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, SH3GL2 - sh3-domain grb2-like 2]" GO:0051716 cellular response to stimulus 1.60E-10 1.53E-07 1.42 16376 4825 548 230 "[A2M - alpha-2-macroglobulin, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, REV3L - rev3-like, polymerase (dna directed), zeta, catalytic subunit, CAB39L - calcium binding protein 39-like, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RGR - retinal g protein coupled receptor, LIFR - leukemia inhibitory factor receptor alpha, OS9 - osteosarcoma amplified 9, endoplasmic reticulum lectin, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, NCAM1 - neural cell adhesion molecule 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, KSR1 - kinase suppressor of ras 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, EGR3 - early growth response 3, CPE - carboxypeptidase e, PLXNA2 - plexin a2, EPS8L1 - eps8-like 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), DHRS2 - dehydrogenase/reductase (sdr family) member 2, PLCD1 - phospholipase c, delta 1, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, STK38L - serine/threonine kinase 38 like, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), AMOTL2 - angiomotin like 2, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), HIST3H2A - histone cluster 3, h2a, RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, BCL10 - b-cell cll/lymphoma 10, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), CAPS - calcyphosine, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), RAD54B - rad54 homolog b (s. cerevisiae), INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, CTSK - cathepsin k, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, EYA1 - eyes absent homolog 1 (drosophila), UVRAG - uv radiation resistance associated, ACKR3 - atypical chemokine receptor 3, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), BOC - boc cell adhesion associated, oncogene regulated, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, GAB2 - grb2-associated binding protein 2, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, TP53TG1 - tp53 target 1 (non-protein coding), APC - adenomatous polyposis coli, PIAS1 - protein inhibitor of activated stat, 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, CYTL1 - cytokine-like 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, DUSP10 - dual specificity phosphatase 10, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, GPC4 - glypican 4, GPR162 - g protein-coupled receptor 162, IL31RA - interleukin 31 receptor a, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, SPATA18 - spermatogenesis associated 18, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, PTPRD - protein tyrosine phosphatase, receptor type, d, ARHGAP9 - rho gtpase activating protein 9, ZFAND5 - zinc finger, an1-type domain 5, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP2 - timp metallopeptidase inhibitor 2, EPC2 - enhancer of polycomb homolog 2 (drosophila), ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), CHN2 - chimerin 2, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CHL1 - cell adhesion molecule l1-like, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, WSB1 - wd repeat and socs box containing 1, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, HBP1 - hmg-box transcription factor 1, SMOC1 - sparc related modular calcium binding 1, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SPARCL1 - sparc-like 1 (hevin), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ZFYVE26 - zinc finger, fyve domain containing 26, RASD1 - ras, dexamethasone-induced 1, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CXCL2 - chemokine (c-x-c motif) ligand 2, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, SGK1 - serum/glucocorticoid regulated kinase 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0048523 negative regulation of cellular process 2.39E-10 1.97E-07 1.58 16376 3110 548 164 "[BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, TAGLN3 - transgelin 3, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAB39L - calcium binding protein 39-like, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RFX3 - regulatory factor x, 3 (influences hla class ii expression), PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, DACT3 - dishevelled-binding antagonist of beta-catenin 3, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, DFNA5 - deafness, autosomal dominant 5, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), CBX4 - chromobox homolog 4, DHRS2 - dehydrogenase/reductase (sdr family) member 2, FKBP1B - fk506 binding protein 1b, 12.6 kda, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, ADA - adenosine deaminase, PTBP2 - polypyrimidine tract binding protein 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SLIT1 - slit homolog 1 (drosophila), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, CDH5 - cadherin 5, type 2 (vascular endothelium), SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), ADM - adrenomedullin, FBN2 - fibrillin 2, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, CAPN3 - calpain 3, (p94), RUFY3 - run and fyve domain containing 3, PTX3 - pentraxin 3, long, CAPG - capping protein (actin filament), gelsolin-like, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, CHL1 - cell adhesion molecule l1-like, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, CYR61 - cysteine-rich, angiogenic inducer, 61, CRBN - cereblon, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, ANXA1 - annexin a1, KAT6B - k(lysine) acetyltransferase 6b, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, NR1D2 - nuclear receptor subfamily 1, group d, member 2, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0065007 biological regulation 4.02E-10 3.11E-07 1.22 16376 9281 548 380 "[CREB5 - camp responsive element binding protein 5, MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, CAB39L - calcium binding protein 39-like, TSHZ2 - teashirt zinc finger homeobox 2, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RGR - retinal g protein coupled receptor, RFX4 - regulatory factor x, 4 (influences hla class ii expression), LIFR - leukemia inhibitory factor receptor alpha, RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, OS9 - osteosarcoma amplified 9, endoplasmic reticulum lectin, BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, PNRC1 - proline-rich nuclear receptor coactivator 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, SCG3 - secretogranin iii, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, NCAM1 - neural cell adhesion molecule 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, KSR1 - kinase suppressor of ras 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, CPE - carboxypeptidase e, PLXNA2 - plexin a2, EPS8L1 - eps8-like 1, PIFO - primary cilia formation, BIK - bcl2-interacting killer (apoptosis-inducing), ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, PLCD1 - phospholipase c, delta 1, DOCK10 - dedicator of cytokinesis 10, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, CCNDBP1 - cyclin d-type binding-protein 1, STK38L - serine/threonine kinase 38 like, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADA - adenosine deaminase, PTBP2 - polypyrimidine tract binding protein 2, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), AMOTL2 - angiomotin like 2, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HSD17B11 - hydroxysteroid (17-beta) dehydrogenase 11, HES5 - hairy and enhancer of split 5 (drosophila), CAPS - calcyphosine, TTC21B - tetratricopeptide repeat domain 21b, MTTP - microsomal triglyceride transfer protein, CAPN3 - calpain 3, (p94), CAPG - capping protein (actin filament), gelsolin-like, ARID5B - at rich interactive domain 5b (mrf1-like), SYT1 - synaptotagmin i, ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, SERINC5 - serine incorporator 5, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, BEX2 - brain expressed x-linked 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, ACKR3 - atypical chemokine receptor 3, UVRAG - uv radiation resistance associated, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, CRIPT - cysteine-rich pdz-binding protein, CCNL1 - cyclin l1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, MICU1 - mitochondrial calcium uptake 1, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG2 - cyclin g2, POLR3GL - polymerase (rna) iii (dna directed) polypeptide g (32kd)-like, CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, ATP8A1 - atpase, aminophospholipid transporter (aplt), class i, type 8a, member 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, GAD1 - glutamate decarboxylase 1 (brain, 67kda), RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, NIN - ninein (gsk3b interacting protein), EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), BOC - boc cell adhesion associated, oncogene regulated, CRBN - cereblon, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846, GAS1 - growth arrest-specific 1, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, PAIP1 - poly(a) binding protein interacting protein 1, FN1 - fibronectin 1, ZNF638 - zinc finger protein 638, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), IGFBPL1 - insulin-like growth factor binding protein-like 1, DCX - doublecortin, STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, DFNA5 - deafness, autosomal dominant 5, TMEM27 - transmembrane protein 27, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, SLC4A11 - solute carrier family 4, sodium borate transporter, member 11, KDM3A - lysine (k)-specific demethylase 3a, CD200 - cd200 molecule, DUSP10 - dual specificity phosphatase 10, C1orf85 - chromosome 1 open reading frame 85, SLC38A2 - solute carrier family 38, member 2, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, SESN3 - sestrin 3, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, SCN3A - sodium channel, voltage-gated, type iii, alpha subunit, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, CLIC6 - chloride intracellular channel 6, FAM107A - family with sequence similarity 107, member a, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, GPC4 - glypican 4, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, GPR162 - g protein-coupled receptor 162, IL31RA - interleukin 31 receptor a, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, SERINC1 - serine incorporator 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, IGSF11 - immunoglobulin superfamily, member 11, TBC1D8 - tbc1 domain family, member 8 (with gram domain), CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, TSPAN31 - tetraspanin 31, SAT1 - spermidine/spermine n1-acetyltransferase 1, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, ZFAND5 - zinc finger, an1-type domain 5, FBN2 - fibrillin 2, KAT7 - k(lysine) acetyltransferase 7, MGST2 - microsomal glutathione s-transferase 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, COG3 - component of oligomeric golgi complex 3, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP4 - timp metallopeptidase inhibitor 4, EPC2 - enhancer of polycomb homolog 2 (drosophila), RUFY3 - run and fyve domain containing 3, PTX3 - pentraxin 3, long, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), HKDC1 - hexokinase domain containing 1, DPP6 - dipeptidyl-peptidase 6, ANKRD6 - ankyrin repeat domain 6, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, PILRB - paired immunoglobin-like type 2 receptor beta, CHL1 - cell adhesion molecule l1-like, DOCK6 - dedicator of cytokinesis 6, MAOA - monoamine oxidase a, WSB1 - wd repeat and socs box containing 1, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, NID1 - nidogen 1, HBP1 - hmg-box transcription factor 1, MAP7 - microtubule-associated protein 7, SMOC1 - sparc related modular calcium binding 1, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, FNDC5 - fibronectin type iii domain containing 5, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SPARCL1 - sparc-like 1 (hevin), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, RBM24 - rna binding motif protein 24, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, SNCAIP - synuclein, alpha interacting protein, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, BCHE - butyrylcholinesterase, NECAB3 - n-terminal ef-hand calcium binding protein 3, AK3 - adenylate kinase 3, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, SH3GL2 - sh3-domain grb2-like 2]" GO:1902680 positive regulation of RNA biosynthetic process 6.72E-10 4.89E-07 2.06 16376 1131 548 78 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CAPN3 - calpain 3, (p94), PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0050789 regulation of biological process 8.41E-10 5.78E-07 1.23 16376 8851 548 365 "[CREB5 - camp responsive element binding protein 5, MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, CAB39L - calcium binding protein 39-like, TSHZ2 - teashirt zinc finger homeobox 2, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RGR - retinal g protein coupled receptor, RFX4 - regulatory factor x, 4 (influences hla class ii expression), LIFR - leukemia inhibitory factor receptor alpha, RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PNRC1 - proline-rich nuclear receptor coactivator 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, NCAM1 - neural cell adhesion molecule 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, KSR1 - kinase suppressor of ras 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, CPE - carboxypeptidase e, PLXNA2 - plexin a2, EPS8L1 - eps8-like 1, PIFO - primary cilia formation, BIK - bcl2-interacting killer (apoptosis-inducing), ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, PLCD1 - phospholipase c, delta 1, DOCK10 - dedicator of cytokinesis 10, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, CCNDBP1 - cyclin d-type binding-protein 1, STK38L - serine/threonine kinase 38 like, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADA - adenosine deaminase, PTBP2 - polypyrimidine tract binding protein 2, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), AMOTL2 - angiomotin like 2, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), CAPS - calcyphosine, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), CAPG - capping protein (actin filament), gelsolin-like, ARID5B - at rich interactive domain 5b (mrf1-like), SYT1 - synaptotagmin i, ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, SERINC5 - serine incorporator 5, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, BEX2 - brain expressed x-linked 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, ACKR3 - atypical chemokine receptor 3, UVRAG - uv radiation resistance associated, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, CRIPT - cysteine-rich pdz-binding protein, CCNL1 - cyclin l1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG2 - cyclin g2, POLR3GL - polymerase (rna) iii (dna directed) polypeptide g (32kd)-like, CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), BOC - boc cell adhesion associated, oncogene regulated, CRBN - cereblon, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, ZNF846 - zinc finger protein 846, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, PAIP1 - poly(a) binding protein interacting protein 1, FN1 - fibronectin 1, ZNF638 - zinc finger protein 638, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), IGFBPL1 - insulin-like growth factor binding protein-like 1, DCX - doublecortin, STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, DFNA5 - deafness, autosomal dominant 5, TMEM27 - transmembrane protein 27, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, CD200 - cd200 molecule, DUSP10 - dual specificity phosphatase 10, C1orf85 - chromosome 1 open reading frame 85, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, SESN3 - sestrin 3, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, SCN3A - sodium channel, voltage-gated, type iii, alpha subunit, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, CLIC6 - chloride intracellular channel 6, FAM107A - family with sequence similarity 107, member a, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, GPC4 - glypican 4, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, GPR162 - g protein-coupled receptor 162, IL31RA - interleukin 31 receptor a, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, SERINC1 - serine incorporator 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, IGSF11 - immunoglobulin superfamily, member 11, TBC1D8 - tbc1 domain family, member 8 (with gram domain), CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, TSPAN31 - tetraspanin 31, SAT1 - spermidine/spermine n1-acetyltransferase 1, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, ZFAND5 - zinc finger, an1-type domain 5, FBN2 - fibrillin 2, KAT7 - k(lysine) acetyltransferase 7, MGST2 - microsomal glutathione s-transferase 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, COG3 - component of oligomeric golgi complex 3, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP4 - timp metallopeptidase inhibitor 4, EPC2 - enhancer of polycomb homolog 2 (drosophila), RUFY3 - run and fyve domain containing 3, PTX3 - pentraxin 3, long, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), DPP6 - dipeptidyl-peptidase 6, ANKRD6 - ankyrin repeat domain 6, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, PILRB - paired immunoglobin-like type 2 receptor beta, CHL1 - cell adhesion molecule l1-like, DOCK6 - dedicator of cytokinesis 6, WSB1 - wd repeat and socs box containing 1, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, NID1 - nidogen 1, HBP1 - hmg-box transcription factor 1, SMOC1 - sparc related modular calcium binding 1, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, FNDC5 - fibronectin type iii domain containing 5, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SPARCL1 - sparc-like 1 (hevin), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, RBM24 - rna binding motif protein 24, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, SNCAIP - synuclein, alpha interacting protein, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, BCHE - butyrylcholinesterase, NECAB3 - n-terminal ef-hand calcium binding protein 3, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, SH3GL2 - sh3-domain grb2-like 2]" GO:0009653 anatomical structure morphogenesis 1.25E-09 8.13E-07 2.01 16376 1189 548 80 "[HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, FN1 - fibronectin 1, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), GSN - gelsolin, FREM2 - fras1 related extracellular matrix protein 2, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), DCX - doublecortin, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, RPE65 - retinal pigment epithelium-specific protein 65kda, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8, ERRFI1 - erbb receptor feedback inhibitor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, SP8 - sp8 transcription factor, CPE - carboxypeptidase e, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, EYA4 - eyes absent homolog 4 (drosophila), CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ATL1 - atlastin gtpase 1, GPC4 - glypican 4, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, S100A4 - s100 calcium binding protein a4, EPHB1 - eph receptor b1, SPRY2 - sprouty homolog 2 (drosophila), S100A6 - s100 calcium binding protein a6, SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), EPHA4 - eph receptor a4, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, CYR61 - cysteine-rich, angiogenic inducer, 61, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, FBN2 - fibrillin 2, ZFAND5 - zinc finger, an1-type domain 5, GAS1 - growth arrest-specific 1]" GO:0051254 positive regulation of RNA metabolic process 1.56E-09 9.66E-07 2.02 16376 1152 548 78 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CAPN3 - calpain 3, (p94), PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0042127 regulation of cell proliferation 1.83E-09 1.08E-06 1.97 16376 1242 548 82 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, PAX6 - paired box 6, LIFR - leukemia inhibitory factor receptor alpha, CTGF - connective tissue growth factor, PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), BTG1 - b-cell translocation gene 1, anti-proliferative, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, TSPYL5 - tspy-like 5, DFNA5 - deafness, autosomal dominant 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, GPER1 - g protein-coupled estrogen receptor 1, PLCD1 - phospholipase c, delta 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, MORC3 - morc family cw-type zinc finger 3, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, MXI1 - max interactor 1, dimerization protein, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI1 - pellino e3 ubiquitin protein ligase 1, S100A6 - s100 calcium binding protein a6, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, TSPAN31 - tetraspanin 31, CDH5 - cadherin 5, type 2 (vascular endothelium), SAT1 - spermidine/spermine n1-acetyltransferase 1, DACH1 - dachshund homolog 1 (drosophila), KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, ADM - adrenomedullin, ANXA1 - annexin a1, BCHE - butyrylcholinesterase, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:0006357 regulation of transcription from RNA polymerase II promoter 2.59E-09 1.46E-06 1.89 16376 1405 548 89 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TAGLN3 - transgelin 3, TTC21B - tetratricopeptide repeat domain 21b, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, ZBTB18 - zinc finger and btb domain containing 18, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, ZNF641 - zinc finger protein 641, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, AHRR - aryl-hydrocarbon receptor repressor, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, MAML3 - mastermind-like 3 (drosophila), INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, MED18 - mediator complex subunit 18, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:2000026 regulation of multicellular organismal development 3.17E-09 1.71E-06 1.96 16376 1235 548 81 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, CAPN3 - calpain 3, (p94), RUFY3 - run and fyve domain containing 3, PAX6 - paired box 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, BTG1 - b-cell translocation gene 1, anti-proliferative, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, APOLD1 - apolipoprotein l domain containing 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, LRP6 - low density lipoprotein receptor-related protein 6, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, ITPKB - inositol-trisphosphate 3-kinase b, TGFBR1 - transforming growth factor, beta receptor 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, FBN2 - fibrillin 2, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0009893 positive regulation of metabolic process 4.90E-09 2.53E-06 1.65 16376 2263 548 125 "[CREB5 - camp responsive element binding protein 5, PAIP1 - poly(a) binding protein interacting protein 1, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SDCBP - syndecan binding protein (syntenin), PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), EN1 - engrailed homeobox 1, APC - adenomatous polyposis coli, KLF5 - kruppel-like factor 5 (intestinal), PIAS1 - protein inhibitor of activated stat, 1, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, CYTL1 - cytokine-like 1, ELF1 - e74-like factor 1 (ets domain transcription factor), KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, SOX6 - sry (sex determining region y)-box 6, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, NOTCH4 - notch 4, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), PILRB - paired immunoglobin-like type 2 receptor beta, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, UVRAG - uv radiation resistance associated, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, TPP1 - tripeptidyl peptidase i, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, KAT6B - k(lysine) acetyltransferase 6b, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0010604 positive regulation of macromolecule metabolic process 5.32E-09 2.63E-06 1.69 16376 2050 548 116 "[CREB5 - camp responsive element binding protein 5, PAIP1 - poly(a) binding protein interacting protein 1, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), PBX1 - pre-b-cell leukemia homeobox 1, EN1 - engrailed homeobox 1, APC - adenomatous polyposis coli, KLF5 - kruppel-like factor 5 (intestinal), PIAS1 - protein inhibitor of activated stat, 1, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, CYTL1 - cytokine-like 1, ELF1 - e74-like factor 1 (ets domain transcription factor), KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, FAM175A - family with sequence similarity 175, member a, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CAPN3 - calpain 3, (p94), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), PILRB - paired immunoglobin-like type 2 receptor beta, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, TPP1 - tripeptidyl peptidase i, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KAT6B - k(lysine) acetyltransferase 6b, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0010243 response to organonitrogen compound 6.34E-09 2.80E-06 2.38 16376 654 548 52 "[TIMP4 - timp metallopeptidase inhibitor 4, CAB39L - calcium binding protein 39-like, GSN - gelsolin, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, CTGF - connective tissue growth factor, JAG1 - jagged 1, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, EGR1 - early growth response 1, PDGFD - platelet derived growth factor d, ADA - adenosine deaminase, ADCY8 - adenylate cyclase 8 (brain), TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ADCY2 - adenylate cyclase 2 (brain), AKAP7 - a kinase (prka) anchor protein 7, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, ADM - adrenomedullin, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, MGST2 - microsomal glutathione s-transferase 2]" GO:0048519 negative regulation of biological process 5.96E-09 2.84E-06 1.49 16376 3399 548 170 "[A2M - alpha-2-macroglobulin, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, TAGLN3 - transgelin 3, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAB39L - calcium binding protein 39-like, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RFX3 - regulatory factor x, 3 (influences hla class ii expression), PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, DACT3 - dishevelled-binding antagonist of beta-catenin 3, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, DFNA5 - deafness, autosomal dominant 5, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, DHRS2 - dehydrogenase/reductase (sdr family) member 2, FKBP1B - fk506 binding protein 1b, 12.6 kda, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, ADA - adenosine deaminase, PTBP2 - polypyrimidine tract binding protein 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SLIT1 - slit homolog 1 (drosophila), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, CDH5 - cadherin 5, type 2 (vascular endothelium), SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), ADM - adrenomedullin, FBN2 - fibrillin 2, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, CAPN3 - calpain 3, (p94), RUFY3 - run and fyve domain containing 3, PTX3 - pentraxin 3, long, CAPG - capping protein (actin filament), gelsolin-like, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, CHL1 - cell adhesion molecule l1-like, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, TRIM62 - tripartite motif containing 62, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, CYR61 - cysteine-rich, angiogenic inducer, 61, CRBN - cereblon, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, ANXA1 - annexin a1, KAT6B - k(lysine) acetyltransferase 6b, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, NR1D2 - nuclear receptor subfamily 1, group d, member 2, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0010033 response to organic substance 6.34E-09 2.91E-06 1.68 16376 2104 548 118 "[CAB39L - calcium binding protein 39-like, F11R - f11 receptor, RGR - retinal g protein coupled receptor, GSN - gelsolin, LIFR - leukemia inhibitory factor receptor alpha, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, NCAM1 - neural cell adhesion molecule 1, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, MGST2 - microsomal glutathione s-transferase 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP4 - timp metallopeptidase inhibitor 4, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, CTGF - connective tissue growth factor, JAG1 - jagged 1, MAP2 - microtubule-associated protein 2, INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, ACKR3 - atypical chemokine receptor 3, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, KLF15 - kruppel-like factor 15, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, ACSBG1 - acyl-coa synthetase bubblegum family member 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, NR1D2 - nuclear receptor subfamily 1, group d, member 2, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:1901698 response to nitrogen compound 1.00E-08 4.28E-06 2.3 16376 702 548 54 "[IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP4 - timp metallopeptidase inhibitor 4, CAB39L - calcium binding protein 39-like, GSN - gelsolin, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, CTGF - connective tissue growth factor, JAG1 - jagged 1, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, EGR1 - early growth response 1, PDGFD - platelet derived growth factor d, ADA - adenosine deaminase, ADCY8 - adenylate cyclase 8 (brain), TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ADCY2 - adenylate cyclase 2 (brain), AKAP7 - a kinase (prka) anchor protein 7, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, PELI1 - pellino e3 ubiquitin protein ligase 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, ADM - adrenomedullin, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, MGST2 - microsomal glutathione s-transferase 2]" GO:0045935 positive regulation of nucleobase-containing compound metabolic process 1.08E-08 4.48E-06 1.9 16376 1291 548 82 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, FAM175A - family with sequence similarity 175, member a, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0051173 positive regulation of nitrogen compound metabolic process 1.20E-08 4.78E-06 1.88 16376 1316 548 83 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, FAM175A - family with sequence similarity 175, member a, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KAT6B - k(lysine) acetyltransferase 6b, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0010557 positive regulation of macromolecule biosynthetic process 1.65E-08 6.39E-06 1.89 16376 1281 548 81 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, CAPN3 - calpain 3, (p94), PAIP1 - poly(a) binding protein interacting protein 1, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0009719 response to endogenous stimulus 1.71E-08 6.42E-06 1.93 16376 1194 548 77 "[TIMP4 - timp metallopeptidase inhibitor 4, CAB39L - calcium binding protein 39-like, F11R - f11 receptor, GSN - gelsolin, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, CTGF - connective tissue growth factor, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, RPE65 - retinal pigment epithelium-specific protein 65kda, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, JUND - jun d proto-oncogene, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ADA - adenosine deaminase, ADCY8 - adenylate cyclase 8 (brain), TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, ACSBG1 - acyl-coa synthetase bubblegum family member 1, RORB - rar-related orphan receptor b, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, NR1D2 - nuclear receptor subfamily 1, group d, member 2, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, NR4A1 - nuclear receptor subfamily 4, group a, member 1, MGST2 - microsomal glutathione s-transferase 2]" GO:0031325 positive regulation of cellular metabolic process 1.83E-08 6.65E-06 1.65 16376 2143 548 118 "[CREB5 - camp responsive element binding protein 5, PAIP1 - poly(a) binding protein interacting protein 1, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SDCBP - syndecan binding protein (syntenin), PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), EN1 - engrailed homeobox 1, KLF5 - kruppel-like factor 5 (intestinal), PIAS1 - protein inhibitor of activated stat, 1, GADD45G - growth arrest and dna-damage-inducible, gamma, CYTL1 - cytokine-like 1, ELF1 - e74-like factor 1 (ets domain transcription factor), KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, FAM175A - family with sequence similarity 175, member a, SOX6 - sry (sex determining region y)-box 6, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, CTGF - connective tissue growth factor, NOTCH4 - notch 4, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), PILRB - paired immunoglobin-like type 2 receptor beta, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ACKR3 - atypical chemokine receptor 3, UVRAG - uv radiation resistance associated, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, TPP1 - tripeptidyl peptidase i, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, KAT6B - k(lysine) acetyltransferase 6b, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0070887 cellular response to chemical stimulus 1.99E-08 7.04E-06 1.72 16376 1789 548 103 "[CAB39L - calcium binding protein 39-like, F11R - f11 receptor, RGR - retinal g protein coupled receptor, GSN - gelsolin, LIFR - leukemia inhibitory factor receptor alpha, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, NCAM1 - neural cell adhesion molecule 1, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, DHRS2 - dehydrogenase/reductase (sdr family) member 2, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, CAPN3 - calpain 3, (p94), CTGF - connective tissue growth factor, MAP2 - microtubule-associated protein 2, RPE65 - retinal pigment epithelium-specific protein 65kda, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ACKR3 - atypical chemokine receptor 3, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EPHB1 - eph receptor b1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0060255 regulation of macromolecule metabolic process 3.02E-08 1.04E-05 1.37 16376 4678 548 215 "[CREB5 - camp responsive element binding protein 5, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, TSHZ2 - teashirt zinc finger homeobox 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, ZNF426 - zinc finger protein 426, ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), HES4 - hairy and enhancer of split 4 (drosophila), APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, MXI1 - max interactor 1, dimerization protein, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, EID2B - ep300 interacting inhibitor of differentiation 2b, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, NRARP - notch-regulated ankyrin repeat protein, ZBTB18 - zinc finger and btb domain containing 18, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, EYA1 - eyes absent homolog 1 (drosophila), CCNL1 - cyclin l1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NR4A3 - nuclear receptor subfamily 4, group a, member 3, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, ZNF846 - zinc finger protein 846, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, FN1 - fibronectin 1, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, PAX6 - paired box 6, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, DUSP10 - dual specificity phosphatase 10, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), KAT7 - k(lysine) acetyltransferase 7, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, COG3 - component of oligomeric golgi complex 3, TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), KDM5B - lysine (k)-specific demethylase 5b, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, HBP1 - hmg-box transcription factor 1, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, MORC3 - morc family cw-type zinc finger 3, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, RBM24 - rna binding motif protein 24, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, NECAB3 - n-terminal ef-hand calcium binding protein 3, SH3GL2 - sh3-domain grb2-like 2]" GO:0045597 positive regulation of cell differentiation 3.19E-08 1.07E-05 2.41 16376 570 548 46 "[TIMP2 - timp metallopeptidase inhibitor 2, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PAX6 - paired box 6, JUND - jun d proto-oncogene, FNDC5 - fibronectin type iii domain containing 5, RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, MAP2K6 - mitogen-activated protein kinase kinase 6, BTG1 - b-cell translocation gene 1, anti-proliferative, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, ITPKB - inositol-trisphosphate 3-kinase b, APC - adenomatous polyposis coli, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, INSM1 - insulinoma-associated 1, ZEB2 - zinc finger e-box binding homeobox 2, SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, S100A10 - s100 calcium binding protein a10, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NKX6-1 - nk6 homeobox 1, ADM - adrenomedullin, GPER1 - g protein-coupled estrogen receptor 1, PTPRD - protein tyrosine phosphatase, receptor type, d, FBN2 - fibrillin 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0023051 regulation of signaling 3.39E-08 1.10E-05 1.61 16376 2264 548 122 "[A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RAB8B - rab8b, member ras oncogene family, RFX3 - regulatory factor x, 3 (influences hla class ii expression), SDCBP - syndecan binding protein (syntenin), GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, PIAS1 - protein inhibitor of activated stat, 1, DFNA5 - deafness, autosomal dominant 5, GADD45G - growth arrest and dna-damage-inducible, gamma, TMEM27 - transmembrane protein 27, EPS8L1 - eps8-like 1, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, FBN2 - fibrillin 2, ARHGAP9 - rho gtpase activating protein 9, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, SNCAIP - synuclein, alpha interacting protein, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, SEZ6L - seizure related 6 homolog (mouse)-like, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), CYR61 - cysteine-rich, angiogenic inducer, 61, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0006355 "regulation of transcription, DNA-templated" 3.53E-08 1.12E-05 1.5 16376 3042 548 153 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, BTG1 - b-cell translocation gene 1, anti-proliferative, EN1 - engrailed homeobox 1, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, MXI1 - max interactor 1, dimerization protein, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, EBF1 - early b-cell factor 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, PDE2A - phosphodiesterase 2a, cgmp-stimulated, KLF6 - kruppel-like factor 6, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, SP8 - sp8 transcription factor, ZBTB18 - zinc finger and btb domain containing 18, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, ZNF641 - zinc finger protein 641, CCNL1 - cyclin l1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0031328 positive regulation of cellular biosynthetic process 3.82E-08 1.15E-05 1.83 16376 1373 548 84 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PAIP1 - poly(a) binding protein interacting protein 1, PTX3 - pentraxin 3, long, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KAT6B - k(lysine) acetyltransferase 6b, ADM - adrenomedullin, ANXA1 - annexin a1, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0009891 positive regulation of biosynthetic process 3.75E-08 1.16E-05 1.82 16376 1395 548 85 "[CREB5 - camp responsive element binding protein 5, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PAIP1 - poly(a) binding protein interacting protein 1, PTX3 - pentraxin 3, long, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EBF1 - early b-cell factor 1, ZNF711 - zinc finger protein 711, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, KLF6 - kruppel-like factor 6, KLF13 - kruppel-like factor 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KAT6B - k(lysine) acetyltransferase 6b, ADM - adrenomedullin, ANXA1 - annexin a1, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0010646 regulation of cell communication 4.82E-08 1.42E-05 1.6 16376 2278 548 122 "[A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RAB8B - rab8b, member ras oncogene family, RFX3 - regulatory factor x, 3 (influences hla class ii expression), SDCBP - syndecan binding protein (syntenin), GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, PIAS1 - protein inhibitor of activated stat, 1, DFNA5 - deafness, autosomal dominant 5, GADD45G - growth arrest and dna-damage-inducible, gamma, TMEM27 - transmembrane protein 27, EPS8L1 - eps8-like 1, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, FBN2 - fibrillin 2, ARHGAP9 - rho gtpase activating protein 9, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, SNCAIP - synuclein, alpha interacting protein, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, SEZ6L - seizure related 6 homolog (mouse)-like, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), CYR61 - cysteine-rich, angiogenic inducer, 61, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0009966 regulation of signal transduction 4.96E-08 1.43E-05 1.65 16376 2012 548 111 "[A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, SDCBP - syndecan binding protein (syntenin), GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, PIAS1 - protein inhibitor of activated stat, 1, DFNA5 - deafness, autosomal dominant 5, GADD45G - growth arrest and dna-damage-inducible, gamma, EPS8L1 - eps8-like 1, BIK - bcl2-interacting killer (apoptosis-inducing), ELF1 - e74-like factor 1 (ets domain transcription factor), AKAP13 - a kinase (prka) anchor protein 13, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, FBN2 - fibrillin 2, ARHGAP9 - rho gtpase activating protein 9, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, SEZ6L - seizure related 6 homolog (mouse)-like, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), CYR61 - cysteine-rich, angiogenic inducer, 61, CSPG4 - chondroitin sulfate proteoglycan 4, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0048583 regulation of response to stimulus 5.25E-08 1.48E-05 1.54 16376 2679 548 138 "[A2M - alpha-2-macroglobulin, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, SDCBP - syndecan binding protein (syntenin), STXBP5 - syntaxin binding protein 5 (tomosyn), GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, PIAS1 - protein inhibitor of activated stat, 1, MYO10 - myosin x, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, EPS8L1 - eps8-like 1, TMEM27 - transmembrane protein 27, BIK - bcl2-interacting killer (apoptosis-inducing), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), ELF1 - e74-like factor 1 (ets domain transcription factor), APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, CD200 - cd200 molecule, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SESN3 - sestrin 3, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, SLIT1 - slit homolog 1 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, ARHGAP9 - rho gtpase activating protein 9, FBN2 - fibrillin 2, HES5 - hairy and enhancer of split 5 (drosophila), IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, SEZ6L - seizure related 6 homolog (mouse)-like, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0071310 cellular response to organic substance 6.34E-08 1.71E-05 1.76 16376 1526 548 90 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, CAB39L - calcium binding protein 39-like, F11R - f11 receptor, RGR - retinal g protein coupled receptor, LIFR - leukemia inhibitory factor receptor alpha, CTGF - connective tissue growth factor, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), MAP2 - microtubule-associated protein 2, RPE65 - retinal pigment epithelium-specific protein 65kda, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, HDAC5 - histone deacetylase 5, NCAM1 - neural cell adhesion molecule 1, ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, ACKR3 - atypical chemokine receptor 3, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), FZD7 - frizzled family receptor 7, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, FGD3 - fyve, rhogef and ph domain containing 3, RORB - rar-related orphan receptor b, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, SPRY2 - sprouty homolog 2 (drosophila), TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), DAPK1 - death-associated protein kinase 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0048513 organ development 6.32E-08 1.74E-05 1.98 16376 1013 548 67 "[HES5 - hairy and enhancer of split 5 (drosophila), CAPN3 - calpain 3, (p94), PAX6 - paired box 6, ARID5B - at rich interactive domain 5b (mrf1-like), ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, DCX - doublecortin, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, EGR3 - early growth response 3, FAM65B - family with sequence similarity 65, member b, FOXP2 - forkhead box p2, BIK - bcl2-interacting killer (apoptosis-inducing), EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, PLCD1 - phospholipase c, delta 1, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SMOC1 - sparc related modular calcium binding 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), CCNG1 - cyclin g1, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), COL9A3 - collagen, type ix, alpha 3, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SOX6 - sry (sex determining region y)-box 6, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, VCAN - versican, GAS1 - growth arrest-specific 1, PCDH18 - protocadherin 18]" GO:2001141 regulation of RNA biosynthetic process 7.89E-08 2.04E-05 1.48 16376 3079 548 153 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0051239 regulation of multicellular organismal process 7.79E-08 2.05E-05 1.65 16376 1957 548 108 "[ITM2C - integral membrane protein 2c, PAX6 - paired box 6, RAB8B - rab8b, member ras oncogene family, RFX3 - regulatory factor x, 3 (influences hla class ii expression), STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, ELF1 - e74-like factor 1 (ets domain transcription factor), APOLD1 - apolipoprotein l domain containing 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, SLIT1 - slit homolog 1 (drosophila), SOX6 - sry (sex determining region y)-box 6, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, FBN2 - fibrillin 2, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), RUFY3 - run and fyve domain containing 3, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SMOC1 - sparc related modular calcium binding 1, PROX1 - prospero homeobox 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), POLR3GL - polymerase (rna) iii (dna directed) polypeptide g (32kd)-like, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ITPKB - inositol-trisphosphate 3-kinase b, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, DTX4 - deltex homolog 4 (drosophila), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, ANXA1 - annexin a1, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0051252 regulation of RNA metabolic process 8.71E-08 2.20E-05 1.47 16376 3161 548 156 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0071495 cellular response to endogenous stimulus 9.75E-08 2.41E-05 2.1 16376 813 548 57 "[CAB39L - calcium binding protein 39-like, F11R - f11 receptor, CTGF - connective tissue growth factor, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), RPE65 - retinal pigment epithelium-specific protein 65kda, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ADCY8 - adenylate cyclase 8 (brain), MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, RORB - rar-related orphan receptor b, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0042325 regulation of phosphorylation 1.05E-07 2.46E-05 1.92 16376 1092 548 70 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, PIFO - primary cilia formation, ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, CCNL1 - cyclin l1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, INSM1 - insulinoma-associated 1, EPHB1 - eph receptor b1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, NBR1 - neighbor of brca1 gene 1, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:1901652 response to peptide 1.04E-07 2.47E-05 2.75 16376 370 548 34 "[KLF15 - kruppel-like factor 15, TIMP4 - timp metallopeptidase inhibitor 4, FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, EGR1 - early growth response 1, JAG1 - jagged 1, INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, ADCY8 - adenylate cyclase 8 (brain), TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), ADCY2 - adenylate cyclase 2 (brain), GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, NKX6-1 - nk6 homeobox 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, GPER1 - g protein-coupled estrogen receptor 1, ADM - adrenomedullin, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7]" GO:0051253 negative regulation of RNA metabolic process 1.02E-07 2.49E-05 2.02 16376 919 548 62 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0042221 response to chemical 1.12E-07 2.56E-05 1.52 16376 2687 548 137 "[CAB39L - calcium binding protein 39-like, F11R - f11 receptor, RGR - retinal g protein coupled receptor, GSN - gelsolin, LIFR - leukemia inhibitory factor receptor alpha, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, NCAM1 - neural cell adhesion molecule 1, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), DHRS2 - dehydrogenase/reductase (sdr family) member 2, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SLIT1 - slit homolog 1 (drosophila), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, MGST2 - microsomal glutathione s-transferase 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, MTTP - microsomal triglyceride transfer protein, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), TIMP4 - timp metallopeptidase inhibitor 4, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, SYT1 - synaptotagmin i, CTGF - connective tissue growth factor, JAG1 - jagged 1, MAP2 - microtubule-associated protein 2, ABCB4 - atp-binding cassette, sub-family b (mdr/tap), member 4, INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, ACKR3 - atypical chemokine receptor 3, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, KLF15 - kruppel-like factor 15, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, TPP1 - tripeptidyl peptidase i, GAD1 - glutamate decarboxylase 1 (brain, 67kda), TGFBR1 - transforming growth factor, beta receptor 1, ACSBG1 - acyl-coa synthetase bubblegum family member 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, CYR61 - cysteine-rich, angiogenic inducer, 61, CXCL2 - chemokine (c-x-c motif) ligand 2, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0045944 positive regulation of transcription from RNA polymerase II promoter 1.29E-07 2.90E-05 2.09 16376 799 548 56 "[CREB5 - camp responsive element binding protein 5, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, CYTL1 - cytokine-like 1, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, ATXN1 - ataxin 1, JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, DLL1 - delta-like 1 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), MAML3 - mastermind-like 3 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, SOX6 - sry (sex determining region y)-box 6, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0009967 positive regulation of signal transduction 1.54E-07 3.40E-05 1.95 16376 994 548 65 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), TRPS1 - trichorhinophalangeal syndrome i, CHN2 - chimerin 2, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NRARP - notch-regulated ankyrin repeat protein, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, TRIM62 - tripartite motif containing 62, KIAA1161 - kiaa1161, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, S100A4 - s100 calcium binding protein a4, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, CYR61 - cysteine-rich, angiogenic inducer, 61, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CSPG4 - chondroitin sulfate proteoglycan 4, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1]" GO:0023056 positive regulation of signaling 1.76E-07 3.81E-05 1.92 16376 1041 548 67 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), TRPS1 - trichorhinophalangeal syndrome i, CHN2 - chimerin 2, DKK1 - dickkopf wnt signaling pathway inhibitor 1, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, TRIM62 - tripartite motif containing 62, KIAA1161 - kiaa1161, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, S100A4 - s100 calcium binding protein a4, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, CYR61 - cysteine-rich, angiogenic inducer, 61, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CSPG4 - chondroitin sulfate proteoglycan 4, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1]" GO:0048731 system development 2.06E-07 4.40E-05 2.24 16376 627 548 47 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, TIMP2 - timp metallopeptidase inhibitor 2, LSAMP - limbic system-associated membrane protein, TAGLN3 - transgelin 3, FGF14 - fibroblast growth factor 14, TIMP4 - timp metallopeptidase inhibitor 4, FGFR3 - fibroblast growth factor receptor 3, IGSF8 - immunoglobulin superfamily, member 8, PAX6 - paired box 6, ACVR2A - activin a receptor, type iia, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), PTCH1 - patched 1, RNF103 - ring finger protein 103, DLL3 - delta-like 3 (drosophila), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DCX - doublecortin, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, FZD7 - frizzled family receptor 7, TRPS1 - trichorhinophalangeal syndrome i, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, EN1 - engrailed homeobox 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, ERRFI1 - erbb receptor feedback inhibitor 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), SCRG1 - stimulator of chondrogenesis 1, INTU - inturned planar cell polarity protein, EGR3 - early growth response 3, ZEB2 - zinc finger e-box binding homeobox 2, PLXNA2 - plexin a2, SULF2 - sulfatase 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, EYA1 - eyes absent homolog 1 (drosophila), ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, HES4 - hairy and enhancer of split 4 (drosophila), CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), PCDHB2 - protocadherin beta 2, OSR2 - odd-skipped related 2 (drosophila), ZFAND5 - zinc finger, an1-type domain 5, MOBP - myelin-associated oligodendrocyte basic protein, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2, SH3GL2 - sh3-domain grb2-like 2]" GO:0010647 positive regulation of cell communication 2.09E-07 4.40E-05 1.91 16376 1046 548 67 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), TRPS1 - trichorhinophalangeal syndrome i, CHN2 - chimerin 2, DKK1 - dickkopf wnt signaling pathway inhibitor 1, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, TRIM62 - tripartite motif containing 62, KIAA1161 - kiaa1161, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, S100A4 - s100 calcium binding protein a4, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, CYR61 - cysteine-rich, angiogenic inducer, 61, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CSPG4 - chondroitin sulfate proteoglycan 4, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1]" GO:0007165 signal transduction 2.13E-07 4.40E-05 1.4 16376 3917 548 183 "[A2M - alpha-2-macroglobulin, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, CAB39L - calcium binding protein 39-like, PAX6 - paired box 6, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, F11R - f11 receptor, RGR - retinal g protein coupled receptor, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, LIFR - leukemia inhibitory factor receptor alpha, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, NCAM1 - neural cell adhesion molecule 1, APC - adenomatous polyposis coli, DACT3 - dishevelled-binding antagonist of beta-catenin 3, KLF9 - kruppel-like factor 9, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, PIAS1 - protein inhibitor of activated stat, 1, KSR1 - kinase suppressor of ras 1, RLBP1 - retinaldehyde binding protein 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, MYO10 - myosin x, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, PLXNA2 - plexin a2, CPE - carboxypeptidase e, EPS8L1 - eps8-like 1, CYTL1 - cytokine-like 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, PLCD1 - phospholipase c, delta 1, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, STK38L - serine/threonine kinase 38 like, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), GPC4 - glypican 4, IL31RA - interleukin 31 receptor a, GPR162 - g protein-coupled receptor 162, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), RND3 - rho family gtpase 3, AMOTL2 - angiomotin like 2, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, AKAP7 - a kinase (prka) anchor protein 7, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), S100A6 - s100 calcium binding protein a6, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAT4 - fat atypical cadherin 4, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, ARHGAP9 - rho gtpase activating protein 9, ZFAND5 - zinc finger, an1-type domain 5, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, CAPS - calcyphosine, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TTC21B - tetratricopeptide repeat domain 21b, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CHL1 - cell adhesion molecule l1-like, INSIG2 - insulin induced gene 2, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, RPE65 - retinal pigment epithelium-specific protein 65kda, WSB1 - wd repeat and socs box containing 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, HHAT - hedgehog acyltransferase, CTSK - cathepsin k, DUSP4 - dual specificity phosphatase 4, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, ACKR3 - atypical chemokine receptor 3, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, SMOC1 - sparc related modular calcium binding 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SPARCL1 - sparc-like 1 (hevin), TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, GRIA3 - glutamate receptor, ionotropic, ampa 3, ITPKB - inositol-trisphosphate 3-kinase b, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, DTX4 - deltex homolog 4 (drosophila), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0008284 positive regulation of cell proliferation 2.55E-07 5.18E-05 2.16 16376 692 548 50 "[HES5 - hairy and enhancer of split 5 (drosophila), PAX6 - paired box 6, LIFR - leukemia inhibitory factor receptor alpha, CTGF - connective tissue growth factor, PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), GAB2 - grb2-associated binding protein 2, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ATF3 - activating transcription factor 3, KLF5 - kruppel-like factor 5 (intestinal), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, TSPYL5 - tspy-like 5, EGR3 - early growth response 3, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, EYA1 - eyes absent homolog 1 (drosophila), GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, TSC22D1 - tsc22 domain family, member 1, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, HAS2 - hyaluronan synthase 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, INSM1 - insulinoma-associated 1, S100A6 - s100 calcium binding protein a6, PELI1 - pellino e3 ubiquitin protein ligase 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, TSPAN31 - tetraspanin 31, ADM - adrenomedullin, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:0010468 regulation of gene expression 2.84E-07 5.68E-05 1.39 16376 3879 548 181 "[CREB5 - camp responsive element binding protein 5, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, PAIP1 - poly(a) binding protein interacting protein 1, FN1 - fibronectin 1, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, CD109 - cd109 molecule, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, PLP1 - proteolipid protein 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, COG3 - component of oligomeric golgi complex 3, TTC21B - tetratricopeptide repeat domain 21b, TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, MORC3 - morc family cw-type zinc finger 3, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RBM24 - rna binding motif protein 24, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, ZNF846 - zinc finger protein 846]" GO:0007166 cell surface receptor signaling pathway 2.97E-07 5.84E-05 1.55 16376 2329 548 121 "[CAB39L - calcium binding protein 39-like, F11R - f11 receptor, PAX6 - paired box 6, RGR - retinal g protein coupled receptor, LIFR - leukemia inhibitory factor receptor alpha, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), LPAR6 - lysophosphatidic acid receptor 6, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, NCAM1 - neural cell adhesion molecule 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, APCDD1 - adenomatosis polyposis coli down-regulated 1, PIAS1 - protein inhibitor of activated stat, 1, MYO10 - myosin x, PLP1 - proteolipid protein 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, CPE - carboxypeptidase e, PLXNA2 - plexin a2, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), AKAP13 - a kinase (prka) anchor protein 13, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, GPR162 - g protein-coupled receptor 162, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), AMOTL2 - angiomotin like 2, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), MAML3 - mastermind-like 3 (drosophila), SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, PTPRD - protein tyrosine phosphatase, receptor type, d, ZFAND5 - zinc finger, an1-type domain 5, HES5 - hairy and enhancer of split 5 (drosophila), IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TTC21B - tetratricopeptide repeat domain 21b, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, PILRB - paired immunoglobin-like type 2 receptor beta, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPR18 - g protein-coupled receptor 18, ACKR3 - atypical chemokine receptor 3, NKX6-1 - nk6 homeobox 1, TTBK2 - tau tubulin kinase 2, GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), PDGFD - platelet derived growth factor d, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, GRIA3 - glutamate receptor, ionotropic, ampa 3, ITPKB - inositol-trisphosphate 3-kinase b, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, DTX4 - deltex homolog 4 (drosophila), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR4A1 - nuclear receptor subfamily 4, group a, member 1, SH3GL2 - sh3-domain grb2-like 2]" GO:1902679 negative regulation of RNA biosynthetic process 3.45E-07 6.68E-05 1.99 16376 887 548 59 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), ZEB2 - zinc finger e-box binding homeobox 2, SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0045892 "negative regulation of transcription, DNA-templated" 4.06E-07 7.74E-05 1.99 16376 870 548 58 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), ZEB2 - zinc finger e-box binding homeobox 2, SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0010629 negative regulation of gene expression 4.38E-07 8.22E-05 1.93 16376 958 548 62 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0019222 regulation of metabolic process 4.75E-07 8.78E-05 1.29 16376 5590 548 242 "[CREB5 - camp responsive element binding protein 5, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, TSHZ2 - teashirt zinc finger homeobox 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, PIFO - primary cilia formation, EPS8L1 - eps8-like 1, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, ZNF426 - zinc finger protein 426, ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), HES4 - hairy and enhancer of split 4 (drosophila), APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, GPSM2 - g-protein signaling modulator 2, PTBP2 - polypyrimidine tract binding protein 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), SERINC5 - serine incorporator 5, CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, EID2B - ep300 interacting inhibitor of differentiation 2b, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, EYA1 - eyes absent homolog 1 (drosophila), UVRAG - uv radiation resistance associated, ACKR3 - atypical chemokine receptor 3, CCNL1 - cyclin l1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, ZNF846 - zinc finger protein 846, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, FN1 - fibronectin 1, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, PAX6 - paired box 6, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, SDCBP - syndecan binding protein (syntenin), STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, DUSP10 - dual specificity phosphatase 10, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, SERINC1 - serine incorporator 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, S100A10 - s100 calcium binding protein a10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, KAT7 - k(lysine) acetyltransferase 7, MGST2 - microsomal glutathione s-transferase 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, COG3 - component of oligomeric golgi complex 3, TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, NOTCH4 - notch 4, KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, HBP1 - hmg-box transcription factor 1, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, MORC3 - morc family cw-type zinc finger 3, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, RBM24 - rna binding motif protein 24, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, NECAB3 - n-terminal ef-hand calcium binding protein 3, SH3GL2 - sh3-domain grb2-like 2]" GO:0060284 regulation of cell development 5.63E-07 1.02E-04 2.23 16376 589 548 44 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, CAPN3 - calpain 3, (p94), CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, RUFY3 - run and fyve domain containing 3, PAX6 - paired box 6, LRP6 - low density lipoprotein receptor-related protein 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, BTG1 - b-cell translocation gene 1, anti-proliferative, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, HDAC5 - histone deacetylase 5, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SLIT1 - slit homolog 1 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, S100A10 - s100 calcium binding protein a10, BAMBI - bmp and activin membrane-bound inhibitor, BOC - boc cell adhesion associated, oncogene regulated, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, PTPRD - protein tyrosine phosphatase, receptor type, d, FYN - fyn oncogene related to src, fgr, yes, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0048584 positive regulation of response to stimulus 6.53E-07 1.17E-04 1.74 16376 1374 548 80 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, TSPAN14 - tetraspanin 14, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GAB2 - grb2-associated binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, CTSK - cathepsin k, MYO10 - myosin x, DUSP4 - dual specificity phosphatase 4, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, TRIM62 - tripartite motif containing 62, KIAA1161 - kiaa1161, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, S100A4 - s100 calcium binding protein a4, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), TP53INP1 - tumor protein p53 inducible nuclear protein 1, ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, FAM175A - family with sequence similarity 175, member a, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, BCL10 - b-cell cll/lymphoma 10, SULF2 - sulfatase 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CSPG4 - chondroitin sulfate proteoglycan 4, SH3BGRL - sh3 domain binding glutamic acid-rich protein like, GAS1 - growth arrest-specific 1]" GO:0045934 negative regulation of nucleobase-containing compound metabolic process 7.22E-07 1.28E-04 1.88 16376 1016 548 64 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:2000112 regulation of cellular macromolecule biosynthetic process 8.44E-07 1.47E-04 1.42 16376 3327 548 158 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NECAB3 - n-terminal ef-hand calcium binding protein 3, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0019219 regulation of nucleobase-containing compound metabolic process 8.99E-07 1.55E-04 1.38 16376 3889 548 179 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, EPS8L1 - eps8-like 1, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, SOX6 - sry (sex determining region y)-box 6, MED18 - mediator complex subunit 18, S100A10 - s100 calcium binding protein a10, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, INSIG2 - insulin induced gene 2, DOCK6 - dedicator of cytokinesis 6, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0010605 negative regulation of macromolecule metabolic process 9.56E-07 1.62E-04 1.69 16376 1504 548 85 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, A2M - alpha-2-macroglobulin, TIMP2 - timp metallopeptidase inhibitor 2, TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, KDM5B - lysine (k)-specific demethylase 5b, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GADD45G - growth arrest and dna-damage-inducible, gamma, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, EGR1 - early growth response 1, AHRR - aryl-hydrocarbon receptor repressor, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, KAT6B - k(lysine) acetyltransferase 6b, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, GAS1 - growth arrest-specific 1, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0050678 regulation of epithelial cell proliferation 1.07E-06 1.77E-04 3.08 16376 233 548 24 "[TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, PAX6 - paired box 6, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), EGR3 - early growth response 3, NRARP - notch-regulated ankyrin repeat protein, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, FOXP2 - forkhead box p2, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, EYA1 - eyes absent homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, THBS4 - thrombospondin 4, FZD7 - frizzled family receptor 7, MAP2K5 - mitogen-activated protein kinase kinase 5, OSR2 - odd-skipped related 2 (drosophila), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, APC - adenomatous polyposis coli]" GO:0007167 enzyme linked receptor protein signaling pathway 1.06E-06 1.77E-04 2.06 16376 726 548 50 "[CAB39L - calcium binding protein 39-like, F11R - f11 receptor, ARID5B - at rich interactive domain 5b (mrf1-like), LIFR - leukemia inhibitory factor receptor alpha, CTGF - connective tissue growth factor, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), GAB2 - grb2-associated binding protein 2, TRPS1 - trichorhinophalangeal syndrome i, PILRB - paired immunoglobin-like type 2 receptor beta, RPE65 - retinal pigment epithelium-specific protein 65kda, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, DUSP4 - dual specificity phosphatase 4, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, AKAP13 - a kinase (prka) anchor protein 13, FYN - fyn oncogene related to src, fgr, yes, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, SPRY2 - sprouty homolog 2 (drosophila), EPHB1 - eph receptor b1, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, PTPRD - protein tyrosine phosphatase, receptor type, d, ZFAND5 - zinc finger, an1-type domain 5, NR4A1 - nuclear receptor subfamily 4, group a, member 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0045667 regulation of osteoblast differentiation 1.28E-06 2.08E-04 4.44 16376 101 548 15 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, SMOC1 - sparc related modular calcium binding 1, RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, ACVR2A - activin a receptor, type iia, JUND - jun d proto-oncogene, PTCH1 - patched 1, NBR1 - neighbor of brca1 gene 1, CYR61 - cysteine-rich, angiogenic inducer, 61, TWIST1 - twist basic helix-loop-helix transcription factor 1, FBN2 - fibrillin 2, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, BMP7 - bone morphogenetic protein 7]" GO:0051172 negative regulation of nitrogen compound metabolic process 1.41E-06 2.26E-04 1.85 16376 1036 548 64 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0044763 single-organism cellular process 1.56E-06 2.47E-04 1.19 16376 8522 548 339 "[CREB5 - camp responsive element binding protein 5, MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, REV3L - rev3-like, polymerase (dna directed), zeta, catalytic subunit, CAB39L - calcium binding protein 39-like, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX3 - regulatory factor x, 3 (influences hla class ii expression), PCDHB16 - protocadherin beta 16, OS9 - osteosarcoma amplified 9, endoplasmic reticulum lectin, BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, AASS - aminoadipate-semialdehyde synthase, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, SCG3 - secretogranin iii, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, NCAM1 - neural cell adhesion molecule 1, KLF5 - kruppel-like factor 5 (intestinal), C8orf4 - chromosome 8 open reading frame 4, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, PLOD2 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, EHHADH - enoyl-coa, hydratase/3-hydroxyacyl coa dehydrogenase, PLXNA2 - plexin a2, PIFO - primary cilia formation, BIK - bcl2-interacting killer (apoptosis-inducing), HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, MFSD6 - major facilitator superfamily domain containing 6, MINPP1 - multiple inositol-polyphosphate phosphatase 1, PLCD1 - phospholipase c, delta 1, KAT2B - k(lysine) acetyltransferase 2b, MYO5B - myosin vb, BMP7 - bone morphogenetic protein 7, SERAC1 - serine active site containing 1, CCNDBP1 - cyclin d-type binding-protein 1, ST8SIA5 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 5, GABARAPL1 - gaba(a) receptor-associated protein like 1, ACSS1 - acyl-coa synthetase short-chain family member 1, IGSF8 - immunoglobulin superfamily, member 8, ACVR2A - activin a receptor, type iia, DAAM1 - dishevelled associated activator of morphogenesis 1, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADA - adenosine deaminase, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TP53I3 - tumor protein p53 inducible protein 3, ADCY2 - adenylate cyclase 2 (brain), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), HIST3H2A - histone cluster 3, h2a, COL9A3 - collagen, type ix, alpha 3, RORB - rar-related orphan receptor b, SPRY2 - sprouty homolog 2 (drosophila), SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, GMPR - guanosine monophosphate reductase, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, IDNK - idnk, gluconokinase homolog (e. coli), HSD17B11 - hydroxysteroid (17-beta) dehydrogenase 11, HES5 - hairy and enhancer of split 5 (drosophila), SLC9B1 - solute carrier family 9, subfamily b (nha1, cation proton antiporter 1), member 1, TTC21B - tetratricopeptide repeat domain 21b, MTTP - microsomal triglyceride transfer protein, CAPN3 - calpain 3, (p94), CAPG - capping protein (actin filament), gelsolin-like, FREM2 - fras1 related extracellular matrix protein 2, ARID5B - at rich interactive domain 5b (mrf1-like), SYT1 - synaptotagmin i, CDK19 - cyclin-dependent kinase 19, SERINC5 - serine incorporator 5, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RAD54B - rad54 homolog b (s. cerevisiae), BEX2 - brain expressed x-linked 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, UVRAG - uv radiation resistance associated, ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, CRIPT - cysteine-rich pdz-binding protein, FRMD4B - ferm domain containing 4b, SLC26A11 - solute carrier family 26 (anion exchanger), member 11, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, MICU1 - mitochondrial calcium uptake 1, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), GALNT3 - udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), C9orf72 - chromosome 9 open reading frame 72, CCNG2 - cyclin g2, CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, ATP8A1 - atpase, aminophospholipid transporter (aplt), class i, type 8a, member 1, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, FBXL7 - f-box and leucine-rich repeat protein 7, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, GAD1 - glutamate decarboxylase 1 (brain, 67kda), RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, ACSBG1 - acyl-coa synthetase bubblegum family member 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, NIN - ninein (gsk3b interacting protein), EPHB1 - eph receptor b1, AMPH - amphiphysin, EPHA4 - eph receptor a4, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BAMBI - bmp and activin membrane-bound inhibitor, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, CRBN - cereblon, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, SPON2 - spondin 2, extracellular matrix protein, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SLC7A3 - solute carrier family 7 (cationic amino acid transporter, y+ system), member 3, FN1 - fibronectin 1, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SLC22A18 - solute carrier family 22, member 18, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, STXBP5 - syntaxin binding protein 5 (tomosyn), GAB2 - grb2-associated binding protein 2, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, ZNF521 - zinc finger protein 521, CECR1 - cat eye syndrome chromosome region, candidate 1, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, DFNA5 - deafness, autosomal dominant 5, CYTL1 - cytokine-like 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, SLC4A11 - solute carrier family 4, sodium borate transporter, member 11, DECR1 - 2,4-dienoyl coa reductase 1, mitochondrial, KDM3A - lysine (k)-specific demethylase 3a, DUSP10 - dual specificity phosphatase 10, MSI2 - musashi rna-binding protein 2, SLC38A2 - solute carrier family 38, member 2, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, LRRTM2 - leucine rich repeat transmembrane neuronal 2, SCG2 - secretogranin ii, DNM3 - dynamin 3, FGF14 - fibroblast growth factor 14, SCN3A - sodium channel, voltage-gated, type iii, alpha subunit, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, SLCO1C1 - solute carrier organic anion transporter family, member 1c1, CLIC6 - chloride intracellular channel 6, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, ATL1 - atlastin gtpase 1, GPC4 - glypican 4, RNF144B - ring finger protein 144b, IL31RA - interleukin 31 receptor a, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, SERINC1 - serine incorporator 1, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), S100A6 - s100 calcium binding protein a6, FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, CCDC126 - coiled-coil domain containing 126, CDK17 - cyclin-dependent kinase 17, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), SATB1 - satb homeobox 1, NPTX2 - neuronal pentraxin ii, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ZFAND5 - zinc finger, an1-type domain 5, FBN2 - fibrillin 2, KAT7 - k(lysine) acetyltransferase 7, MGST2 - microsomal glutathione s-transferase 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, COG3 - component of oligomeric golgi complex 3, CRB1 - crumbs homolog 1 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, EPC2 - enhancer of polycomb homolog 2 (drosophila), SLC2A12 - solute carrier family 2 (facilitated glucose transporter), member 12, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, HKDC1 - hexokinase domain containing 1, DPP6 - dipeptidyl-peptidase 6, NOTCH4 - notch 4, NOVA1 - neuro-oncological ventral antigen 1, KDM5B - lysine (k)-specific demethylase 5b, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, ABCB4 - atp-binding cassette, sub-family b (mdr/tap), member 4, CHL1 - cell adhesion molecule l1-like, MAOA - monoamine oxidase a, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FAM65B - family with sequence similarity 65, member b, PCDHB14 - protocadherin beta 14, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, PCDHB10 - protocadherin beta 10, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, PCDHB2 - protocadherin beta 2, DUSP1 - dual specificity phosphatase 1, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), NID1 - nidogen 1, HBP1 - hmg-box transcription factor 1, MAP7 - microtubule-associated protein 7, SMOC1 - sparc related modular calcium binding 1, CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), LRP6 - low density lipoprotein receptor-related protein 6, MORC3 - morc family cw-type zinc finger 3, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, TPPP3 - tubulin polymerization-promoting protein family member 3, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, ZFYVE26 - zinc finger, fyve domain containing 26, RBM24 - rna binding motif protein 24, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, SNCAIP - synuclein, alpha interacting protein, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, GPCPD1 - glycerophosphocholine phosphodiesterase gde1 homolog (s. cerevisiae), ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, NBR1 - neighbor of brca1 gene 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, SPATA13 - spermatogenesis associated 13, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, CCBL2 - cysteine conjugate-beta lyase 2, MGAT4A - mannosyl (alpha-1,3-)-glycoprotein beta-1,4-n-acetylglucosaminyltransferase, isozyme a, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, BCHE - butyrylcholinesterase, NECAB3 - n-terminal ef-hand calcium binding protein 3, AK3 - adenylate kinase 3, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, SH3GL2 - sh3-domain grb2-like 2]" GO:0051171 regulation of nitrogen compound metabolic process 1.60E-06 2.51E-04 1.36 16376 3976 548 181 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, EPS8L1 - eps8-like 1, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, SOX6 - sry (sex determining region y)-box 6, MED18 - mediator complex subunit 18, S100A10 - s100 calcium binding protein a10, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, DOCK6 - dedicator of cytokinesis 6, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, MAP2K6 - mitogen-activated protein kinase kinase 6, ETV1 - ets variant 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0007389 pattern specification process 1.70E-06 2.63E-04 2.52 16376 380 548 32 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HES5 - hairy and enhancer of split 5 (drosophila), CXCR4 - chemokine (c-x-c motif) receptor 4, PAX6 - paired box 6, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, NOTCH4 - notch 4, PBX1 - pre-b-cell leukemia homeobox 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, EN1 - engrailed homeobox 1, APC - adenomatous polyposis coli, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), PCDH8 - protocadherin 8, TGFBR1 - transforming growth factor, beta receptor 1, INTU - inturned planar cell polarity protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, ZEB2 - zinc finger e-box binding homeobox 2, TGIF1 - tgfb-induced factor homeobox 1, PLXNA2 - plexin a2, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), GAS1 - growth arrest-specific 1, BMP7 - bone morphogenetic protein 7]" GO:0043067 regulation of programmed cell death 2.17E-06 3.31E-04 1.76 16376 1208 548 71 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAPN3 - calpain 3, (p94), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, BEX2 - brain expressed x-linked 2, APC - adenomatous polyposis coli, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, BIK - bcl2-interacting killer (apoptosis-inducing), ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), CBX4 - chromobox homolog 4, DHRS2 - dehydrogenase/reductase (sdr family) member 2, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, TSC22D3 - tsc22 domain family, member 3, DUSP1 - dual specificity phosphatase 1, IFIH1 - interferon induced with helicase c domain 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, SPRY2 - sprouty homolog 2 (drosophila), TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, SGK1 - serum/glucocorticoid regulated kinase 1, ADM - adrenomedullin, ANXA1 - annexin a1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:0080090 regulation of primary metabolic process 2.21E-06 3.34E-04 1.3 16376 5041 548 219 "[CREB5 - camp responsive element binding protein 5, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, TSHZ2 - teashirt zinc finger homeobox 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, EPS8L1 - eps8-like 1, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, ZNF426 - zinc finger protein 426, ELF1 - e74-like factor 1 (ets domain transcription factor), HES4 - hairy and enhancer of split 4 (drosophila), APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, DOCK10 - dedicator of cytokinesis 10, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, MXI1 - max interactor 1, dimerization protein, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, EID2B - ep300 interacting inhibitor of differentiation 2b, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, EYA1 - eyes absent homolog 1 (drosophila), CCNL1 - cyclin l1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846, GAS1 - growth arrest-specific 1, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, FN1 - fibronectin 1, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, PAX6 - paired box 6, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, PBX1 - pre-b-cell leukemia homeobox 1, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, DUSP10 - dual specificity phosphatase 10, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, S100A10 - s100 calcium binding protein a10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, KAT7 - k(lysine) acetyltransferase 7, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, HBP1 - hmg-box transcription factor 1, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, NECAB3 - n-terminal ef-hand calcium binding protein 3]" GO:0031323 regulation of cellular metabolic process 2.28E-06 3.40E-04 1.3 16376 5015 548 218 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, TSHZ2 - teashirt zinc finger homeobox 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, PIFO - primary cilia formation, EPS8L1 - eps8-like 1, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), ZNF426 - zinc finger protein 426, ELF1 - e74-like factor 1 (ets domain transcription factor), HES4 - hairy and enhancer of split 4 (drosophila), APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, DOCK10 - dedicator of cytokinesis 10, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, ACVR2A - activin a receptor, type iia, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, MXI1 - max interactor 1, dimerization protein, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, PTBP2 - polypyrimidine tract binding protein 2, ADCY8 - adenylate cyclase 8 (brain), MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), AFAP1L2 - actin filament associated protein 1-like 2, SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, KLF6 - kruppel-like factor 6, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), CTGF - connective tissue growth factor, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, EID2B - ep300 interacting inhibitor of differentiation 2b, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, UVRAG - uv radiation resistance associated, CCNL1 - cyclin l1, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, PAX6 - paired box 6, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, SDCBP - syndecan binding protein (syntenin), PBX1 - pre-b-cell leukemia homeobox 1, ZNF518A - zinc finger protein 518a, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ZNF521 - zinc finger protein 521, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, CYTL1 - cytokine-like 1, CBX4 - chromobox homolog 4, FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, KDM3A - lysine (k)-specific demethylase 3a, C1orf85 - chromosome 1 open reading frame 85, DUSP10 - dual specificity phosphatase 10, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AHRR - aryl-hydrocarbon receptor repressor, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), ARHGAP9 - rho gtpase activating protein 9, KAT7 - k(lysine) acetyltransferase 7, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), KDM5B - lysine (k)-specific demethylase 5b, CHN2 - chimerin 2, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TSPYL5 - tspy-like 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, DUSP1 - dual specificity phosphatase 1, ZNF641 - zinc finger protein 641, ZNF606 - zinc finger protein 606, HBP1 - hmg-box transcription factor 1, TRIM62 - tripartite motif containing 62, IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, KLF13 - kruppel-like factor 13, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, NECAB3 - n-terminal ef-hand calcium binding protein 3, SH3GL2 - sh3-domain grb2-like 2]" GO:0001822 kidney development 2.47E-06 3.65E-04 3.98 16376 120 548 16 "[TGFBR1 - transforming growth factor, beta receptor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PROX1 - prospero homeobox 1, ARID5B - at rich interactive domain 5b (mrf1-like), EGR1 - early growth response 1, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, HAS2 - hyaluronan synthase 2, EYA1 - eyes absent homolog 1 (drosophila), AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), OSR2 - odd-skipped related 2 (drosophila), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, APC - adenomatous polyposis coli, BMP7 - bone morphogenetic protein 7]" GO:0042981 regulation of apoptotic process 2.99E-06 4.35E-04 1.75 16376 1196 548 70 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, ITM2C - integral membrane protein 2c, CAPN3 - calpain 3, (p94), BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, BEX2 - brain expressed x-linked 2, APC - adenomatous polyposis coli, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, BIK - bcl2-interacting killer (apoptosis-inducing), EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, CBX4 - chromobox homolog 4, DHRS2 - dehydrogenase/reductase (sdr family) member 2, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, TSC22D3 - tsc22 domain family, member 3, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, SPRY2 - sprouty homolog 2 (drosophila), TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, SGK1 - serum/glucocorticoid regulated kinase 1, ADM - adrenomedullin, ANXA1 - annexin a1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:1901700 response to oxygen-containing compound 3.46E-06 4.99E-04 1.79 16376 1087 548 65 "[TIMP4 - timp metallopeptidase inhibitor 4, CAB39L - calcium binding protein 39-like, GSN - gelsolin, CTGF - connective tissue growth factor, JAG1 - jagged 1, DKK1 - dickkopf wnt signaling pathway inhibitor 1, INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), GNG2 - guanine nucleotide binding protein (g protein), gamma 2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, NKX6-1 - nk6 homeobox 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAP7 - microtubule-associated protein 7, KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, JUND - jun d proto-oncogene, PTCH1 - patched 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, PDGFD - platelet derived growth factor d, ADA - adenosine deaminase, CD9 - cd9 molecule, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, AKAP7 - a kinase (prka) anchor protein 7, RORB - rar-related orphan receptor b, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI1 - pellino e3 ubiquitin protein ligase 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, ANXA1 - annexin a1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, BCHE - butyrylcholinesterase, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, MGST2 - microsomal glutathione s-transferase 2]" GO:0010556 regulation of macromolecule biosynthetic process 3.65E-06 5.20E-04 1.38 16376 3434 548 159 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, KAT6B - k(lysine) acetyltransferase 6b, NECAB3 - n-terminal ef-hand calcium binding protein 3, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0051094 positive regulation of developmental process 3.85E-06 5.42E-04 1.95 16376 781 548 51 "[TIMP2 - timp metallopeptidase inhibitor 2, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, PAX6 - paired box 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NKX6-1 - nk6 homeobox 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, JUND - jun d proto-oncogene, FNDC5 - fibronectin type iii domain containing 5, CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, MORF4L2 - mortality factor 4 like 2, ADA - adenosine deaminase, MAP2K6 - mitogen-activated protein kinase kinase 6, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, ITPKB - inositol-trisphosphate 3-kinase b, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), INSM1 - insulinoma-associated 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, EPHB1 - eph receptor b1, ZEB2 - zinc finger e-box binding homeobox 2, SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, S100A10 - s100 calcium binding protein a10, BOC - boc cell adhesion associated, oncogene regulated, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, FBN2 - fibrillin 2]" GO:0010941 regulation of cell death 4.57E-06 6.35E-04 1.71 16376 1257 548 72 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAPN3 - calpain 3, (p94), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, BEX2 - brain expressed x-linked 2, APC - adenomatous polyposis coli, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, BIK - bcl2-interacting killer (apoptosis-inducing), EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), CBX4 - chromobox homolog 4, DHRS2 - dehydrogenase/reductase (sdr family) member 2, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, TSC22D3 - tsc22 domain family, member 3, DUSP1 - dual specificity phosphatase 1, IFIH1 - interferon induced with helicase c domain 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, SPRY2 - sprouty homolog 2 (drosophila), TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, SGK1 - serum/glucocorticoid regulated kinase 1, ADM - adrenomedullin, ANXA1 - annexin a1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:0009892 negative regulation of metabolic process 5.04E-06 6.94E-04 1.6 16376 1640 548 88 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, A2M - alpha-2-macroglobulin, TAGLN3 - transgelin 3, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, ARID5B - at rich interactive domain 5b (mrf1-like), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ERRFI1 - erbb receptor feedback inhibitor 1, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GADD45G - growth arrest and dna-damage-inducible, gamma, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, C1orf51 - chromosome 1 open reading frame 51, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, DACH1 - dachshund homolog 1 (drosophila), SATB1 - satb homeobox 1, KAT6B - k(lysine) acetyltransferase 6b, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, GAS1 - growth arrest-specific 1, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0071363 cellular response to growth factor stimulus 5.40E-06 7.35E-04 2.16 16376 539 548 39 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, FGFR3 - fibroblast growth factor receptor 3, F11R - f11 receptor, ACVR2A - activin a receptor, type iia, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), MAP2K5 - mitogen-activated protein kinase kinase 5, ADCY8 - adenylate cyclase 8 (brain), PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, DUSP4 - dual specificity phosphatase 4, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, SPRY2 - sprouty homolog 2 (drosophila), EGR3 - early growth response 3, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, AKAP13 - a kinase (prka) anchor protein 13, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0031324 negative regulation of cellular metabolic process 5.59E-06 7.52E-04 1.63 16376 1524 548 83 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, KDM5B - lysine (k)-specific demethylase 5b, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GADD45G - growth arrest and dna-damage-inducible, gamma, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, OSR2 - odd-skipped related 2 (drosophila), KDM3A - lysine (k)-specific demethylase 3a, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, EGR1 - early growth response 1, AHRR - aryl-hydrocarbon receptor repressor, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, PTBP2 - polypyrimidine tract binding protein 2, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR1D2 - nuclear receptor subfamily 1, group d, member 2, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0051093 negative regulation of developmental process 6.30E-06 8.39E-04 2.08 16376 604 548 42 "[HES5 - hairy and enhancer of split 5 (drosophila), PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, RUFY3 - run and fyve domain containing 3, PAX6 - paired box 6, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), NOTCH4 - notch 4, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, SLIT1 - slit homolog 1 (drosophila), EPHA4 - eph receptor a4, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, THBS4 - thrombospondin 4, NKX6-1 - nk6 homeobox 1, KLF13 - kruppel-like factor 13, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, BMP7 - bone morphogenetic protein 7]" GO:0043408 regulation of MAPK cascade 6.81E-06 8.69E-04 2.19 16376 504 548 37 "[TIMP2 - timp metallopeptidase inhibitor 2, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, SDCBP - syndecan binding protein (syntenin), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, EPHB1 - eph receptor b1, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, CSPG4 - chondroitin sulfate proteoglycan 4, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0008285 negative regulation of cell proliferation 6.60E-06 8.69E-04 2.12 16376 564 548 40 "[TIMP2 - timp metallopeptidase inhibitor 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, PAX6 - paired box 6, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, MORC3 - morc family cw-type zinc finger 3, MXI1 - max interactor 1, dimerization protein, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CD9 - cd9 molecule, BTG1 - b-cell translocation gene 1, anti-proliferative, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, APC - adenomatous polyposis coli, TGFBR1 - transforming growth factor, beta receptor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, RUNX3 - runt-related transcription factor 3, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, INSM1 - insulinoma-associated 1, DFNA5 - deafness, autosomal dominant 5, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PELI1 - pellino e3 ubiquitin protein ligase 1, TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut), CDH5 - cadherin 5, type 2 (vascular endothelium), DACH1 - dachshund homolog 1 (drosophila), KLF13 - kruppel-like factor 13, DHRS2 - dehydrogenase/reductase (sdr family) member 2, GPER1 - g protein-coupled estrogen receptor 1, ADM - adrenomedullin, BCHE - butyrylcholinesterase, F2R - coagulation factor ii (thrombin) receptor, KAT2B - k(lysine) acetyltransferase 2b, GAS1 - growth arrest-specific 1, BMP7 - bone morphogenetic protein 7]" GO:0044707 single-multicellular organism process 6.80E-06 8.76E-04 1.42 16376 2837 548 135 "[MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, FN1 - fibronectin 1, TSHZ2 - teashirt zinc finger homeobox 2, F11R - f11 receptor, PAX6 - paired box 6, RGR - retinal g protein coupled receptor, SLC22A18 - solute carrier family 22, member 18, PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), DKK1 - dickkopf wnt signaling pathway inhibitor 1, SCG3 - secretogranin iii, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, ZNF521 - zinc finger protein 521, CECR1 - cat eye syndrome chromosome region, candidate 1, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, IGDCC3 - immunoglobulin superfamily, dcc subclass, member 3, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, PLXNA2 - plexin a2, MN1 - meningioma (disrupted in balanced translocation) 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, MINPP1 - multiple inositol-polyphosphate phosphatase 1, BMP7 - bone morphogenetic protein 7, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PPL - periplakin, ATXN1 - ataxin 1, PTCH1 - patched 1, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), RORB - rar-related orphan receptor b, COL9A3 - collagen, type ix, alpha 3, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), DACH1 - dachshund homolog 1 (drosophila), ADM - adrenomedullin, SHISA3 - shisa family member 3, ZFAND5 - zinc finger, an1-type domain 5, HES5 - hairy and enhancer of split 5 (drosophila), ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CAPN9 - calpain 9, CHL1 - cell adhesion molecule l1-like, RPE65 - retinal pigment epithelium-specific protein 65kda, DOCK6 - dedicator of cytokinesis 6, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CTSK - cathepsin k, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, INTU - inturned planar cell polarity protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, SP8 - sp8 transcription factor, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), TSC22D3 - tsc22 domain family, member 3, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), CRYBA1 - crystallin, beta a1, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, CD9 - cd9 molecule, MAP2K6 - mitogen-activated protein kinase kinase 6, TPP1 - tripeptidyl peptidase i, RUNX3 - runt-related transcription factor 3, TGFBR1 - transforming growth factor, beta receptor 1, SEZ6L - seizure related 6 homolog (mouse)-like, AMPH - amphiphysin, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, SGK1 - serum/glucocorticoid regulated kinase 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, BCHE - butyrylcholinesterase, AK3 - adenylate kinase 3, VCAN - versican, GAS1 - growth arrest-specific 1]" GO:0031326 regulation of cellular biosynthetic process 6.79E-06 8.84E-04 1.36 16376 3577 548 163 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, ANXA1 - annexin a1, KAT6B - k(lysine) acetyltransferase 6b, NECAB3 - n-terminal ef-hand calcium binding protein 3, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0000122 negative regulation of transcription from RNA polymerase II promoter 7.32E-06 9.24E-04 2.09 16376 587 548 41 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, PTCH1 - patched 1, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, TRPS1 - trichorhinophalangeal syndrome i, NR2F1 - nuclear receptor subfamily 2, group f, member 1, DKK1 - dickkopf wnt signaling pathway inhibitor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, HDAC5 - histone deacetylase 5, CREBRF - creb3 regulatory factor, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, RUNX3 - runt-related transcription factor 3, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), NRARP - notch-regulated ankyrin repeat protein, ZEB2 - zinc finger e-box binding homeobox 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, ZBTB18 - zinc finger and btb domain containing 18, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NKX6-1 - nk6 homeobox 1, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila)]" GO:0032501 multicellular organismal process 7.57E-06 9.46E-04 1.41 16376 2895 548 137 "[MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, FN1 - fibronectin 1, TSHZ2 - teashirt zinc finger homeobox 2, F11R - f11 receptor, PAX6 - paired box 6, RGR - retinal g protein coupled receptor, SLC22A18 - solute carrier family 22, member 18, PBX1 - pre-b-cell leukemia homeobox 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), DKK1 - dickkopf wnt signaling pathway inhibitor 1, SCG3 - secretogranin iii, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, ZNF521 - zinc finger protein 521, CECR1 - cat eye syndrome chromosome region, candidate 1, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, IGDCC3 - immunoglobulin superfamily, dcc subclass, member 3, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, PLXNA2 - plexin a2, MN1 - meningioma (disrupted in balanced translocation) 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, MINPP1 - multiple inositol-polyphosphate phosphatase 1, BMP7 - bone morphogenetic protein 7, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PPL - periplakin, ATXN1 - ataxin 1, PTCH1 - patched 1, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), RORB - rar-related orphan receptor b, COL9A3 - collagen, type ix, alpha 3, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), DACH1 - dachshund homolog 1 (drosophila), ADM - adrenomedullin, SHISA3 - shisa family member 3, ZFAND5 - zinc finger, an1-type domain 5, HES5 - hairy and enhancer of split 5 (drosophila), ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CAPN9 - calpain 9, CHL1 - cell adhesion molecule l1-like, RPE65 - retinal pigment epithelium-specific protein 65kda, DOCK6 - dedicator of cytokinesis 6, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CTSK - cathepsin k, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, INTU - inturned planar cell polarity protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, SP8 - sp8 transcription factor, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, FOXP2 - forkhead box p2, EYA1 - eyes absent homolog 1 (drosophila), TSC22D3 - tsc22 domain family, member 3, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), CRYBA1 - crystallin, beta a1, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, NR2F1 - nuclear receptor subfamily 2, group f, member 1, CD9 - cd9 molecule, MAP2K6 - mitogen-activated protein kinase kinase 6, TPP1 - tripeptidyl peptidase i, RUNX3 - runt-related transcription factor 3, TGFBR1 - transforming growth factor, beta receptor 1, SEZ6L - seizure related 6 homolog (mouse)-like, AMPH - amphiphysin, TGIF1 - tgfb-induced factor homeobox 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, SGK1 - serum/glucocorticoid regulated kinase 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, BCHE - butyrylcholinesterase, AK3 - adenylate kinase 3, VCAN - versican, GAS1 - growth arrest-specific 1]" GO:0048468 cell development 7.74E-06 9.58E-04 2.24 16376 467 548 35 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HES5 - hairy and enhancer of split 5 (drosophila), MAP7 - microtubule-associated protein 7, CRB1 - crumbs homolog 1 (drosophila), CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, PAX6 - paired box 6, GSN - gelsolin, JUND - jun d proto-oncogene, KIAA1161 - kiaa1161, ARID5B - at rich interactive domain 5b (mrf1-like), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2 - microtubule-associated protein 2, CD9 - cd9 molecule, VEZF1 - vascular endothelial zinc finger 1, ETV1 - ets variant 1, EN1 - engrailed homeobox 1, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, RUNX3 - runt-related transcription factor 3, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, INSM1 - insulinoma-associated 1, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, SOX6 - sry (sex determining region y)-box 6, ZBTB18 - zinc finger and btb domain containing 18, SULF2 - sulfatase 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, ADM - adrenomedullin, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, MSI2 - musashi rna-binding protein 2, FZD2 - frizzled family receptor 2]" GO:0030278 regulation of ossification 8.31E-06 1.02E-03 3.32 16376 162 548 18 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, SMOC1 - sparc related modular calcium binding 1, RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, ACVR2A - activin a receptor, type iia, JUND - jun d proto-oncogene, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, NBR1 - neighbor of brca1 gene 1, CYR61 - cysteine-rich, angiogenic inducer, 61, TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, OSR2 - odd-skipped related 2 (drosophila), FBN2 - fibrillin 2, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, BMP7 - bone morphogenetic protein 7]" GO:0043549 regulation of kinase activity 8.60E-06 1.04E-03 1.98 16376 696 548 46 "[PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, ERRFI1 - erbb receptor feedback inhibitor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, EPHA4 - eph receptor a4, PIFO - primary cilia formation, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, AKAP13 - a kinase (prka) anchor protein 13, CCNL1 - cyclin l1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:2000113 negative regulation of cellular macromolecule biosynthetic process 8.81E-06 1.06E-03 1.8 16376 982 548 59 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), ZEB2 - zinc finger e-box binding homeobox 2, SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0009889 regulation of biosynthetic process 8.87E-06 1.06E-03 1.35 16376 3620 548 164 "[CREB5 - camp responsive element binding protein 5, TAGLN3 - transgelin 3, PAIP1 - poly(a) binding protein interacting protein 1, ZNF638 - zinc finger protein 638, TSHZ2 - teashirt zinc finger homeobox 2, PAX6 - paired box 6, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SSBP2 - single-stranded dna binding protein 2, PBX1 - pre-b-cell leukemia homeobox 1, PNRC1 - proline-rich nuclear receptor coactivator 1, TRPS1 - trichorhinophalangeal syndrome i, ZNF518A - zinc finger protein 518a, DKK1 - dickkopf wnt signaling pathway inhibitor 1, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, ZNF521 - zinc finger protein 521, KLF5 - kruppel-like factor 5 (intestinal), KLF9 - kruppel-like factor 9, PIAS1 - protein inhibitor of activated stat, 1, EGR3 - early growth response 3, ZNF548 - zinc finger protein 548, ELAVL2 - elav (embryonic lethal, abnormal vision, drosophila)-like 2 (hu antigen b), CYTL1 - cytokine-like 1, ZNF426 - zinc finger protein 426, HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), CBX4 - chromobox homolog 4, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, TRIM22 - tripartite motif containing 22, TSC22D1 - tsc22 domain family, member 1, C1orf85 - chromosome 1 open reading frame 85, BMP7 - bone morphogenetic protein 7, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, MYCL - v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, IL31RA - interleukin 31 receptor a, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, MAML3 - mastermind-like 3 (drosophila), RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, INSM1 - insulinoma-associated 1, ZBTB24 - zinc finger and btb domain containing 24, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, MED18 - mediator complex subunit 18, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KLF6 - kruppel-like factor 6, ADM - adrenomedullin, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), PAK6 - p21 protein (cdc42/rac)-activated kinase 6, KAT7 - k(lysine) acetyltransferase 7, HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TTC21B - tetratricopeptide repeat domain 21b, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), PTX3 - pentraxin 3, long, ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CTGF - connective tissue growth factor, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), NOTCH4 - notch 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), KDM5B - lysine (k)-specific demethylase 5b, INSIG2 - insulin induced gene 2, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, BAZ2B - bromodomain adjacent to zinc finger domain, 2b, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, BACH2 - btb and cnc homology 1, basic leucine zipper transcription factor 2, EID2B - ep300 interacting inhibitor of differentiation 2b, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, CCNL1 - cyclin l1, ZNF641 - zinc finger protein 641, OSR2 - odd-skipped related 2 (drosophila), F2R - coagulation factor ii (thrombin) receptor, ZNF606 - zinc finger protein 606, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HBP1 - hmg-box transcription factor 1, KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), TRIM62 - tripartite motif containing 62, JUND - jun d proto-oncogene, IRX1 - iroquois homeobox 1, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, RUNX3 - runt-related transcription factor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, ZNF711 - zinc finger protein 711, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, VGLL4 - vestigial like 4 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, KLF13 - kruppel-like factor 13, SGK1 - serum/glucocorticoid regulated kinase 1, ANXA1 - annexin a1, KAT6B - k(lysine) acetyltransferase 6b, NECAB3 - n-terminal ef-hand calcium binding protein 3, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZNF846 - zinc finger protein 846]" GO:0014070 response to organic cyclic compound 1.10E-05 1.29E-03 1.99 16376 660 548 44 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, GSN - gelsolin, JUND - jun d proto-oncogene, PTCH1 - patched 1, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, KLF2 - kruppel-like factor 2 (lung), LRP6 - low density lipoprotein receptor-related protein 6, CTGF - connective tissue growth factor, EGR1 - early growth response 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ADA - adenosine deaminase, EN1 - engrailed homeobox 1, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), TGFBR1 - transforming growth factor, beta receptor 1, AKAP7 - a kinase (prka) anchor protein 7, ACSBG1 - acyl-coa synthetase bubblegum family member 1, RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PELI1 - pellino e3 ubiquitin protein ligase 1, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NKX6-1 - nk6 homeobox 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, ADM - adrenomedullin, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, BCHE - butyrylcholinesterase, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, BMP7 - bone morphogenetic protein 7]" GO:0031399 regulation of protein modification process 1.12E-05 1.29E-03 1.72 16376 1150 548 66 "[HES5 - hairy and enhancer of split 5 (drosophila), CAPN3 - calpain 3, (p94), MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, DUSP4 - dual specificity phosphatase 4, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, CCNL1 - cyclin l1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, KLF15 - kruppel-like factor 15, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, LRP6 - low density lipoprotein receptor-related protein 6, CCNG1 - cyclin g1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0070848 response to growth factor 1.11E-05 1.30E-03 2.1 16376 556 548 39 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, FGFR3 - fibroblast growth factor receptor 3, F11R - f11 receptor, ACVR2A - activin a receptor, type iia, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, HAS2 - hyaluronan synthase 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), MAP2K5 - mitogen-activated protein kinase kinase 5, ADCY8 - adenylate cyclase 8 (brain), PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, DUSP4 - dual specificity phosphatase 4, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, SPRY2 - sprouty homolog 2 (drosophila), EGR3 - early growth response 3, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, AKAP13 - a kinase (prka) anchor protein 13, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0045596 negative regulation of cell differentiation 1.22E-05 1.40E-03 2.19 16376 477 548 35 "[HES5 - hairy and enhancer of split 5 (drosophila), PROX1 - prospero homeobox 1, RUFY3 - run and fyve domain containing 3, FGFR3 - fibroblast growth factor receptor 3, PAX6 - paired box 6, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), DLL1 - delta-like 1 (drosophila), NOTCH4 - notch 4, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, PBX1 - pre-b-cell leukemia homeobox 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, JAG1 - jagged 1, FZD7 - frizzled family receptor 7, DKK1 - dickkopf wnt signaling pathway inhibitor 1, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TGFBR1 - transforming growth factor, beta receptor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, RORB - rar-related orphan receptor b, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, SLIT1 - slit homolog 1 (drosophila), KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, NKX6-1 - nk6 homeobox 1, KLF13 - kruppel-like factor 13, GPER1 - g protein-coupled estrogen receptor 1, BMP7 - bone morphogenetic protein 7]" GO:0001932 regulation of protein phosphorylation 1.23E-05 1.40E-03 1.82 16376 903 548 55 "[HES5 - hairy and enhancer of split 5 (drosophila), MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, DUSP1 - dual specificity phosphatase 1, CCNL1 - cyclin l1, F2R - coagulation factor ii (thrombin) receptor, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, LRP6 - low density lipoprotein receptor-related protein 6, CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0048646 anatomical structure formation involved in morphogenesis 1.38E-05 1.56E-03 1.99 16376 645 548 43 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, FN1 - fibronectin 1, CAPN3 - calpain 3, (p94), PROX1 - prospero homeobox 1, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), DLL3 - delta-like 3 (drosophila), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CCNG1 - cyclin g1, CTGF - connective tissue growth factor, TWIST1 - twist basic helix-loop-helix transcription factor 1, JAG1 - jagged 1, FZD6 - frizzled family receptor 6, DKK1 - dickkopf wnt signaling pathway inhibitor 1, CD9 - cd9 molecule, VEZF1 - vascular endothelial zinc finger 1, KLF5 - kruppel-like factor 5 (intestinal), PCDH8 - protocadherin 8, TGFBR1 - transforming growth factor, beta receptor 1, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, EPHB1 - eph receptor b1, ZEB2 - zinc finger e-box binding homeobox 2, TGIF1 - tgfb-induced factor homeobox 1, PLXNA2 - plexin a2, BCL10 - b-cell cll/lymphoma 10, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, ACKR3 - atypical chemokine receptor 3, SAT1 - spermidine/spermine n1-acetyltransferase 1, TTBK2 - tau tubulin kinase 2, APOLD1 - apolipoprotein l domain containing 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, PLCD1 - phospholipase c, delta 1, CSPG4 - chondroitin sulfate proteoglycan 4, DUSP1 - dual specificity phosphatase 1, FBN2 - fibrillin 2, BMP7 - bone morphogenetic protein 7]" GO:0010942 positive regulation of cell death 1.47E-05 1.64E-03 2.3 16376 402 548 31 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, CTGF - connective tissue growth factor, EGR1 - early growth response 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K6 - mitogen-activated protein kinase kinase 6, BTG1 - b-cell translocation gene 1, anti-proliferative, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, APC - adenomatous polyposis coli, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, GADD45G - growth arrest and dna-damage-inducible, gamma, TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, ANXA1 - annexin a1, ADM - adrenomedullin, DUSP1 - dual specificity phosphatase 1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7]" GO:0009890 negative regulation of biosynthetic process 1.58E-05 1.74E-03 1.72 16376 1093 548 63 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, INSIG2 - insulin induced gene 2, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, GPER1 - g protein-coupled estrogen receptor 1, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0006950 response to stress 1.63E-05 1.79E-03 1.44 16376 2470 548 119 "[BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, FN1 - fibronectin 1, REV3L - rev3-like, polymerase (dna directed), zeta, catalytic subunit, F11R - f11 receptor, PAX6 - paired box 6, OS9 - osteosarcoma amplified 9, endoplasmic reticulum lectin, GAB2 - grb2-associated binding protein 2, VEZF1 - vascular endothelial zinc finger 1, TP53TG1 - tp53 target 1 (non-protein coding), PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, MYO10 - myosin x, PLOD2 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, GADD45G - growth arrest and dna-damage-inducible, gamma, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, FKBP1B - fk506 binding protein 1b, 12.6 kda, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, EGR1 - early growth response 1, HAS2 - hyaluronan synthase 2, ADA - adenosine deaminase, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, HIST3H2A - histone cluster 3, h2a, SPATA18 - spermatogenesis associated 18, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, GMPR - guanosine monophosphate reductase, ADM - adrenomedullin, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, CAPN3 - calpain 3, (p94), EPC2 - enhancer of polycomb homolog 2 (drosophila), HIST2H2BE - histone cluster 2, h2be, PTX3 - pentraxin 3, long, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RAD54B - rad54 homolog b (s. cerevisiae), HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CTSK - cathepsin k, CHD2 - chromodomain helicase dna binding protein 2, DUSP4 - dual specificity phosphatase 4, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, UVRAG - uv radiation resistance associated, EYA1 - eyes absent homolog 1 (drosophila), TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, MICU1 - mitochondrial calcium uptake 1, EYA4 - eyes absent homolog 4 (drosophila), CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), TRIM62 - tripartite motif containing 62, KLF2 - kruppel-like factor 2 (lung), POLR3GL - polymerase (rna) iii (dna directed) polypeptide g (32kd)-like, CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, MORF4L2 - mortality factor 4 like 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, CD9 - cd9 molecule, MAP2K5 - mitogen-activated protein kinase kinase 5, ZFYVE26 - zinc finger, fyve domain containing 26, MAP2K6 - mitogen-activated protein kinase kinase 6, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, TPP1 - tripeptidyl peptidase i, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, PELI1 - pellino e3 ubiquitin protein ligase 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), DTX4 - deltex homolog 4 (drosophila), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, SGK1 - serum/glucocorticoid regulated kinase 1, SPON2 - spondin 2, extracellular matrix protein, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0032989 cellular component morphogenesis 1.65E-05 1.80E-03 2.33 16376 385 548 30 "[MAP7 - microtubule-associated protein 7, TTC21B - tetratricopeptide repeat domain 21b, PROX1 - prospero homeobox 1, FN1 - fibronectin 1, FGFR3 - fibroblast growth factor receptor 3, GSN - gelsolin, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), DCX - doublecortin, NOTCH4 - notch 4, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, FZD6 - frizzled family receptor 6, MAP2 - microtubule-associated protein 2, DKK1 - dickkopf wnt signaling pathway inhibitor 1, ATL1 - atlastin gtpase 1, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, S100A4 - s100 calcium binding protein a4, EPHB1 - eph receptor b1, S100A6 - s100 calcium binding protein a6, SOX6 - sry (sex determining region y)-box 6, EPHA4 - eph receptor a4, SSBP1 - single-stranded dna binding protein 1, mitochondrial, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), FYN - fyn oncogene related to src, fgr, yes, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7]" GO:0010558 negative regulation of macromolecule biosynthetic process 1.76E-05 1.90E-03 1.74 16376 1028 548 60 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0031327 negative regulation of cellular biosynthetic process 1.87E-05 2.00E-03 1.72 16376 1076 548 62 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TAGLN3 - transgelin 3, CAPN3 - calpain 3, (p94), ARID5B - at rich interactive domain 5b (mrf1-like), TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), RFX3 - regulatory factor x, 3 (influences hla class ii expression), TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TRPS1 - trichorhinophalangeal syndrome i, KDM5B - lysine (k)-specific demethylase 5b, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, INSIG2 - insulin induced gene 2, ATF3 - activating transcription factor 3, HDAC5 - histone deacetylase 5, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, PIAS1 - protein inhibitor of activated stat, 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, ZBTB18 - zinc finger and btb domain containing 18, NKX6-1 - nk6 homeobox 1, CBX4 - chromobox homolog 4, TSC22D3 - tsc22 domain family, member 3, OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, EPC1 - enhancer of polycomb homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, MXI1 - max interactor 1, dimerization protein, NR2F1 - nuclear receptor subfamily 2, group f, member 1, C1orf51 - chromosome 1 open reading frame 51, MAP2K5 - mitogen-activated protein kinase kinase 5, RASD1 - ras, dexamethasone-induced 1, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), CREBRF - creb3 regulatory factor, RUNX3 - runt-related transcription factor 3, RORB - rar-related orphan receptor b, INSM1 - insulinoma-associated 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SOX6 - sry (sex determining region y)-box 6, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), KAT6B - k(lysine) acetyltransferase 6b, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0009725 response to hormone 1.98E-05 2.10E-03 1.9 16376 741 548 47 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, TIMP4 - timp metallopeptidase inhibitor 4, FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, JUND - jun d proto-oncogene, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, EGR1 - early growth response 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, INSIG2 - insulin induced gene 2, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, RPE65 - retinal pigment epithelium-specific protein 65kda, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, HDAC5 - histone deacetylase 5, ADCY2 - adenylate cyclase 2 (brain), KLF9 - kruppel-like factor 9, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), ACSBG1 - acyl-coa synthetase bubblegum family member 1, RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EGR3 - early growth response 3, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, NKX6-1 - nk6 homeobox 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, GPER1 - g protein-coupled estrogen receptor 1, ANXA1 - annexin a1, ADM - adrenomedullin, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, BCHE - butyrylcholinesterase, KDM3A - lysine (k)-specific demethylase 3a, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7]" GO:0043434 response to peptide hormone 2.06E-05 2.17E-03 2.38 16376 351 548 28 "[TIMP4 - timp metallopeptidase inhibitor 4, FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, JUND - jun d proto-oncogene, LRP6 - low density lipoprotein receptor-related protein 6, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, EGR1 - early growth response 1, INSIG2 - insulin induced gene 2, RPE65 - retinal pigment epithelium-specific protein 65kda, ADCY8 - adenylate cyclase 8 (brain), TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, HDAC5 - histone deacetylase 5, ADCY2 - adenylate cyclase 2 (brain), GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, NKX6-1 - nk6 homeobox 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, ANXA1 - annexin a1, GPER1 - g protein-coupled estrogen receptor 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7]" GO:0042327 positive regulation of phosphorylation 2.26E-05 2.35E-03 1.9 16376 723 548 46 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, SDCBP - syndecan binding protein (syntenin), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, ACKR3 - atypical chemokine receptor 3, THBS4 - thrombospondin 4, GPER1 - g protein-coupled estrogen receptor 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0048585 negative regulation of response to stimulus 2.84E-05 2.90E-03 1.76 16376 953 548 56 "[A2M - alpha-2-macroglobulin, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, APC - adenomatous polyposis coli, DACT3 - dishevelled-binding antagonist of beta-catenin 3, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, ELF1 - e74-like factor 1 (ets domain transcription factor), GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, CREBRF - creb3 regulatory factor, TGFBR1 - transforming growth factor, beta receptor 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SPRY2 - sprouty homolog 2 (drosophila), SLIT1 - slit homolog 1 (drosophila), TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), SULF2 - sulfatase 2, ANXA1 - annexin a1, FBN2 - fibrillin 2, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0051090 regulation of sequence-specific DNA binding transcription factor activity 2.82E-05 2.91E-03 2.39 16376 338 548 27 "[PROX1 - prospero homeobox 1, CAPN3 - calpain 3, (p94), TRIM62 - tripartite motif containing 62, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, ARID5B - at rich interactive domain 5b (mrf1-like), LRP6 - low density lipoprotein receptor-related protein 6, TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), FZD6 - frizzled family receptor 6, MAP2K5 - mitogen-activated protein kinase kinase 5, HDAC5 - histone deacetylase 5, MAPK10 - mitogen-activated protein kinase 10, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, PELI1 - pellino e3 ubiquitin protein ligase 1, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), FOS - fbj murine osteosarcoma viral oncogene homolog, CYTL1 - cytokine-like 1, NKX6-1 - nk6 homeobox 1, SGK1 - serum/glucocorticoid regulated kinase 1, TRIM22 - tripartite motif containing 22, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7]" GO:0048598 embryonic morphogenesis 3.19E-05 3.24E-03 2.29 16376 379 548 29 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), ACVR2A - activin a receptor, type iia, PAX6 - paired box 6, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, DLL1 - delta-like 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, FZD6 - frizzled family receptor 6, DKK1 - dickkopf wnt signaling pathway inhibitor 1, INSIG2 - insulin induced gene 2, EN1 - engrailed homeobox 1, PCDH8 - protocadherin 8, TGFBR1 - transforming growth factor, beta receptor 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SPRY2 - sprouty homolog 2 (drosophila), SP8 - sp8 transcription factor, EYA1 - eyes absent homolog 1 (drosophila), NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, OSR2 - odd-skipped related 2 (drosophila), FBN2 - fibrillin 2, GAS1 - growth arrest-specific 1, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7]" GO:0032870 cellular response to hormone stimulus 3.28E-05 3.30E-03 2.18 16376 439 548 32 "[FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ADCY8 - adenylate cyclase 8 (brain), RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, KLF9 - kruppel-like factor 9, ADCY2 - adenylate cyclase 2 (brain), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EGR3 - early growth response 3, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), FOSB - fbj murine osteosarcoma viral oncogene homolog b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, NKX6-1 - nk6 homeobox 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, GPER1 - g protein-coupled estrogen receptor 1, ANXA1 - annexin a1, DUSP1 - dual specificity phosphatase 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, KDM3A - lysine (k)-specific demethylase 3a, NR1D2 - nuclear receptor subfamily 1, group d, member 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, KAT2B - k(lysine) acetyltransferase 2b, BMP7 - bone morphogenetic protein 7]" GO:1902531 regulation of intracellular signal transduction 3.32E-05 3.32E-03 1.66 16376 1167 548 65 "[A2M - alpha-2-macroglobulin, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), MAP3K8 - mitogen-activated protein kinase kinase kinase 8, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, APC - adenomatous polyposis coli, DUSP4 - dual specificity phosphatase 4, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EPS8L1 - eps8-like 1, ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CXCR4 - chemokine (c-x-c motif) receptor 4, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, FGFR3 - fibroblast growth factor receptor 3, TRIM62 - tripartite motif containing 62, KIAA1161 - kiaa1161, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, S100A4 - s100 calcium binding protein a4, EPHB1 - eph receptor b1, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, CSPG4 - chondroitin sulfate proteoglycan 4, ARHGAP9 - rho gtpase activating protein 9]" GO:0040012 regulation of locomotion 3.50E-05 3.47E-03 2.04 16376 543 548 37 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PTX3 - pentraxin 3, long, PAX6 - paired box 6, TRIM62 - tripartite motif containing 62, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, SUN2 - sad1 and unc84 domain containing 2, HAS2 - hyaluronan synthase 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, MAP2K5 - mitogen-activated protein kinase kinase 5, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), TP53INP1 - tumor protein p53 inducible nuclear protein 1, SLIT1 - slit homolog 1 (drosophila), PLXNA2 - plexin a2, KLF4 - kruppel-like factor 4 (gut), CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, DACH1 - dachshund homolog 1 (drosophila), SGK1 - serum/glucocorticoid regulated kinase 1, GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DOCK10 - dedicator of cytokinesis 10]" GO:0008593 regulation of Notch signaling pathway 3.63E-05 3.56E-03 5.38 16376 50 548 9 "[HES5 - hairy and enhancer of split 5 (drosophila), EYA1 - eyes absent homolog 1 (drosophila), JAG1 - jagged 1, TSPAN14 - tetraspanin 14, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, BMP7 - bone morphogenetic protein 7, DLL1 - delta-like 1 (drosophila)]" GO:0050679 positive regulation of epithelial cell proliferation 5.52E-05 5.38E-03 3.27 16376 137 548 15 "[SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, EGR3 - early growth response 3, NRARP - notch-regulated ankyrin repeat protein, FOXP2 - forkhead box p2, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, EYA1 - eyes absent homolog 1 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, THBS4 - thrombospondin 4, FZD7 - frizzled family receptor 7, MAP2K5 - mitogen-activated protein kinase kinase 5, OSR2 - odd-skipped related 2 (drosophila), NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1]" GO:0051270 regulation of cellular component movement 5.56E-05 5.38E-03 2.01 16376 534 548 36 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PAX6 - paired box 6, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, SUN2 - sad1 and unc84 domain containing 2, HAS2 - hyaluronan synthase 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, MAP2K5 - mitogen-activated protein kinase kinase 5, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, TP53INP1 - tumor protein p53 inducible nuclear protein 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SLIT1 - slit homolog 1 (drosophila), PLXNA2 - plexin a2, KLF4 - kruppel-like factor 4 (gut), CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, DACH1 - dachshund homolog 1 (drosophila), GPER1 - g protein-coupled estrogen receptor 1, SGK1 - serum/glucocorticoid regulated kinase 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DOCK10 - dedicator of cytokinesis 10]" GO:0051338 regulation of transferase activity 5.78E-05 5.55E-03 1.8 16376 796 548 48 "[PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, SERINC5 - serine incorporator 5, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, ERRFI1 - erbb receptor feedback inhibitor 1, DUSP4 - dual specificity phosphatase 4, SERINC1 - serine incorporator 1, GADD45G - growth arrest and dna-damage-inducible, gamma, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), EPHA4 - eph receptor a4, PIFO - primary cilia formation, KLF4 - kruppel-like factor 4 (gut), GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, AKAP13 - a kinase (prka) anchor protein 13, CCNL1 - cyclin l1, DUSP1 - dual specificity phosphatase 1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, F2R - coagulation factor ii (thrombin) receptor, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0043065 positive regulation of apoptotic process 6.09E-05 5.80E-03 2.24 16376 373 548 28 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, EGR1 - early growth response 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, GADD45G - growth arrest and dna-damage-inducible, gamma, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, ADM - adrenomedullin, AKAP13 - a kinase (prka) anchor protein 13, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7]" GO:0044699 single-organism process 6.17E-05 5.83E-03 1.13 16376 10136 548 382 "[CREB5 - camp responsive element binding protein 5, MEX3C - mex-3 rna binding family member c, A2M - alpha-2-macroglobulin, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, ITM2C - integral membrane protein 2c, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, AKAP9 - a kinase (prka) anchor protein (yotiao) 9, REV3L - rev3-like, polymerase (dna directed), zeta, catalytic subunit, CAB39L - calcium binding protein 39-like, TSHZ2 - teashirt zinc finger homeobox 2, LGALS8 - lectin, galactoside-binding, soluble, 8, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, RGR - retinal g protein coupled receptor, RFX4 - regulatory factor x, 4 (influences hla class ii expression), RFX3 - regulatory factor x, 3 (influences hla class ii expression), PCDHB16 - protocadherin beta 16, OS9 - osteosarcoma amplified 9, endoplasmic reticulum lectin, BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, AASS - aminoadipate-semialdehyde synthase, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, CA14 - carbonic anhydrase xiv, SCG3 - secretogranin iii, EN1 - engrailed homeobox 1, BTG1 - b-cell translocation gene 1, anti-proliferative, NCAM1 - neural cell adhesion molecule 1, KLF5 - kruppel-like factor 5 (intestinal), C8orf4 - chromosome 8 open reading frame 4, KLF9 - kruppel-like factor 9, APCDD1 - adenomatosis polyposis coli down-regulated 1, RLBP1 - retinaldehyde binding protein 1, MYO10 - myosin x, IGDCC3 - immunoglobulin superfamily, dcc subclass, member 3, PLOD2 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, RAB3D - rab3d, member ras oncogene family, PLP1 - proteolipid protein 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EGR3 - early growth response 3, EHHADH - enoyl-coa, hydratase/3-hydroxyacyl coa dehydrogenase, CPE - carboxypeptidase e, PLXNA2 - plexin a2, PIFO - primary cilia formation, BIK - bcl2-interacting killer (apoptosis-inducing), HES4 - hairy and enhancer of split 4 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), APOLD1 - apolipoprotein l domain containing 1, DHRS2 - dehydrogenase/reductase (sdr family) member 2, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, MFSD6 - major facilitator superfamily domain containing 6, MINPP1 - multiple inositol-polyphosphate phosphatase 1, PLCD1 - phospholipase c, delta 1, KAT2B - k(lysine) acetyltransferase 2b, MYO5B - myosin vb, BMP7 - bone morphogenetic protein 7, SERAC1 - serine active site containing 1, CCNDBP1 - cyclin d-type binding-protein 1, ST8SIA5 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 5, GABARAPL1 - gaba(a) receptor-associated protein like 1, ACSS1 - acyl-coa synthetase short-chain family member 1, IGSF8 - immunoglobulin superfamily, member 8, ACVR2A - activin a receptor, type iia, PPL - periplakin, DAAM1 - dishevelled associated activator of morphogenesis 1, DLL1 - delta-like 1 (drosophila), EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, MXI1 - max interactor 1, dimerization protein, FZD6 - frizzled family receptor 6, C1orf51 - chromosome 1 open reading frame 51, TP53INP2 - tumor protein p53 inducible nuclear protein 2, ADA - adenosine deaminase, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), TP53I3 - tumor protein p53 inducible protein 3, ADCY2 - adenylate cyclase 2 (brain), ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), AKAP7 - a kinase (prka) anchor protein 7, HIST3H2A - histone cluster 3, h2a, COL9A3 - collagen, type ix, alpha 3, RORB - rar-related orphan receptor b, EBF1 - early b-cell factor 1, SPRY2 - sprouty homolog 2 (drosophila), SOX6 - sry (sex determining region y)-box 6, SLIT1 - slit homolog 1 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, SLC25A24 - solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, KLF6 - kruppel-like factor 6, GMPR - guanosine monophosphate reductase, ADM - adrenomedullin, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, IDNK - idnk, gluconokinase homolog (e. coli), HSD17B11 - hydroxysteroid (17-beta) dehydrogenase 11, HES5 - hairy and enhancer of split 5 (drosophila), SLC9B1 - solute carrier family 9, subfamily b (nha1, cation proton antiporter 1), member 1, TTC21B - tetratricopeptide repeat domain 21b, MTTP - microsomal triglyceride transfer protein, CAPN3 - calpain 3, (p94), CAPG - capping protein (actin filament), gelsolin-like, FREM2 - fras1 related extracellular matrix protein 2, ARID5B - at rich interactive domain 5b (mrf1-like), SYT1 - synaptotagmin i, ITGB1BP2 - integrin beta 1 binding protein (melusin) 2, CDK19 - cyclin-dependent kinase 19, SERINC5 - serine incorporator 5, CTGF - connective tissue growth factor, SUN2 - sad1 and unc84 domain containing 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), INSIG2 - insulin induced gene 2, RAD54B - rad54 homolog b (s. cerevisiae), BEX2 - brain expressed x-linked 2, RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, HHAT - hedgehog acyltransferase, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, CTSK - cathepsin k, EID2B - ep300 interacting inhibitor of differentiation 2b, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, NRARP - notch-regulated ankyrin repeat protein, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, ZBTB18 - zinc finger and btb domain containing 18, ACKR3 - atypical chemokine receptor 3, UVRAG - uv radiation resistance associated, EYA1 - eyes absent homolog 1 (drosophila), ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, CRIPT - cysteine-rich pdz-binding protein, FRMD4B - ferm domain containing 4b, SLC26A11 - solute carrier family 26 (anion exchanger), member 11, F2R - coagulation factor ii (thrombin) receptor, OSR2 - odd-skipped related 2 (drosophila), FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, KLF15 - kruppel-like factor 15, MICU1 - mitochondrial calcium uptake 1, AGPAT9 - 1-acylglycerol-3-phosphate o-acyltransferase 9, PROX1 - prospero homeobox 1, EYA4 - eyes absent homolog 4 (drosophila), GALNT3 - udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3), JUND - jun d proto-oncogene, KLF2 - kruppel-like factor 2 (lung), CRYBA1 - crystallin, beta a1, C9orf72 - chromosome 9 open reading frame 72, CCNG2 - cyclin g2, CCNG1 - cyclin g1, CORO1B - coronin, actin binding protein, 1b, TWIST1 - twist basic helix-loop-helix transcription factor 1, ATP8A1 - atpase, aminophospholipid transporter (aplt), class i, type 8a, member 1, CD9 - cd9 molecule, NIPAL3 - nipa-like domain containing 3, MAP2K5 - mitogen-activated protein kinase kinase 5, ETV1 - ets variant 1, MAP2K6 - mitogen-activated protein kinase kinase 6, FBXL7 - f-box and leucine-rich repeat protein 7, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ITPKB - inositol-trisphosphate 3-kinase b, GAD1 - glutamate decarboxylase 1 (brain, 67kda), RUNX3 - runt-related transcription factor 3, MAPK10 - mitogen-activated protein kinase 10, ACSBG1 - acyl-coa synthetase bubblegum family member 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, NIN - ninein (gsk3b interacting protein), EPHB1 - eph receptor b1, AMPH - amphiphysin, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, SSBP1 - single-stranded dna binding protein 1, mitochondrial, KLF4 - kruppel-like factor 4 (gut), BOC - boc cell adhesion associated, oncogene regulated, CRBN - cereblon, PLCXD2 - phosphatidylinositol-specific phospholipase c, x domain containing 2, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, SPON2 - spondin 2, extracellular matrix protein, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SLC7A3 - solute carrier family 7 (cationic amino acid transporter, y+ system), member 3, FN1 - fibronectin 1, F11R - f11 receptor, PAX6 - paired box 6, GSN - gelsolin, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, RAB8B - rab8b, member ras oncogene family, SLC22A18 - solute carrier family 22, member 18, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, STXBP5 - syntaxin binding protein 5 (tomosyn), PBX1 - pre-b-cell leukemia homeobox 1, GAB2 - grb2-associated binding protein 2, VEZF1 - vascular endothelial zinc finger 1, PBXIP1 - pre-b-cell leukemia homeobox interacting protein 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, ZNF521 - zinc finger protein 521, CECR1 - cat eye syndrome chromosome region, candidate 1, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, NCALD - neurocalcin delta, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, DFNA5 - deafness, autosomal dominant 5, CYB5R1 - cytochrome b5 reductase 1, MN1 - meningioma (disrupted in balanced translocation) 1, CYTL1 - cytokine-like 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, SLC4A11 - solute carrier family 4, sodium borate transporter, member 11, DECR1 - 2,4-dienoyl coa reductase 1, mitochondrial, KDM3A - lysine (k)-specific demethylase 3a, DUSP10 - dual specificity phosphatase 10, MSI2 - musashi rna-binding protein 2, SLC38A2 - solute carrier family 38, member 2, SCN1A - sodium channel, voltage-gated, type i, alpha subunit, LRRTM2 - leucine rich repeat transmembrane neuronal 2, SCG2 - secretogranin ii, DNM3 - dynamin 3, SCN3A - sodium channel, voltage-gated, type iii, alpha subunit, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, KIAA1161 - kiaa1161, JMY - junction mediating and regulatory protein, p53 cofactor, PTCH1 - patched 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, SLCO1C1 - solute carrier organic anion transporter family, member 1c1, CLIC6 - chloride intracellular channel 6, HAS2 - hyaluronan synthase 2, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, ATL1 - atlastin gtpase 1, GPC4 - glypican 4, CALHM2 - calcium homeostasis modulator 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, RNF144B - ring finger protein 144b, IL31RA - interleukin 31 receptor a, RND3 - rho family gtpase 3, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, SERINC1 - serine incorporator 1, INSM1 - insulinoma-associated 1, S100A4 - s100 calcium binding protein a4, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, S100A6 - s100 calcium binding protein a6, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAM175A - family with sequence similarity 175, member a, FAT4 - fat atypical cadherin 4, CCDC126 - coiled-coil domain containing 126, CDK17 - cyclin-dependent kinase 17, CLIP3 - cap-gly domain containing linker protein 3, S100A10 - s100 calcium binding protein a10, DAPK1 - death-associated protein kinase 1, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, TBC1D8 - tbc1 domain family, member 8 (with gram domain), CDH5 - cadherin 5, type 2 (vascular endothelium), PDE2A - phosphodiesterase 2a, cgmp-stimulated, SAT1 - spermidine/spermine n1-acetyltransferase 1, SATB1 - satb homeobox 1, DACH1 - dachshund homolog 1 (drosophila), CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), NPTX2 - neuronal pentraxin ii, PTPRD - protein tyrosine phosphatase, receptor type, d, JHDM1D - jumonji c domain containing histone demethylase 1 homolog d (s. cerevisiae), SHISA3 - shisa family member 3, ZFAND5 - zinc finger, an1-type domain 5, FBN2 - fibrillin 2, KAT7 - k(lysine) acetyltransferase 7, MGST2 - microsomal glutathione s-transferase 2, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, COG3 - component of oligomeric golgi complex 3, CRB1 - crumbs homolog 1 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, EPC2 - enhancer of polycomb homolog 2 (drosophila), SLC2A12 - solute carrier family 2 (facilitated glucose transporter), member 12, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), HKDC1 - hexokinase domain containing 1, DPP6 - dipeptidyl-peptidase 6, NOTCH4 - notch 4, NOVA1 - neuro-oncological ventral antigen 1, KDM5B - lysine (k)-specific demethylase 5b, MAP2 - microtubule-associated protein 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CAPN9 - calpain 9, ABCB4 - atp-binding cassette, sub-family b (mdr/tap), member 4, CHL1 - cell adhesion molecule l1-like, DOCK6 - dedicator of cytokinesis 6, MAOA - monoamine oxidase a, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ABCA5 - atp-binding cassette, sub-family a (abc1), member 5, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, INTU - inturned planar cell polarity protein, DUSP4 - dual specificity phosphatase 4, CHD2 - chromodomain helicase dna binding protein 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GPR12 - g protein-coupled receptor 12, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, FAM65B - family with sequence similarity 65, member b, FOXP2 - forkhead box p2, SP8 - sp8 transcription factor, PCDHB14 - protocadherin beta 14, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, PCDHB10 - protocadherin beta 10, TSC22D3 - tsc22 domain family, member 3, GPER1 - g protein-coupled estrogen receptor 1, PCDHB2 - protocadherin beta 2, DUSP1 - dual specificity phosphatase 1, NHS - nance-horan syndrome (congenital cataracts and dental anomalies), NID1 - nidogen 1, HBP1 - hmg-box transcription factor 1, MAP7 - microtubule-associated protein 7, SMOC1 - sparc related modular calcium binding 1, CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, CSPG5 - chondroitin sulfate proteoglycan 5 (neuroglycan c), IRX1 - iroquois homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, MORC3 - morc family cw-type zinc finger 3, NEDD9 - neural precursor cell expressed, developmentally down-regulated 9, DLL3 - delta-like 3 (drosophila), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EPC1 - enhancer of polycomb homolog 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, MORF4L2 - mortality factor 4 like 2, TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, PDGFD - platelet derived growth factor d, TPPP3 - tubulin polymerization-promoting protein family member 3, NR2F1 - nuclear receptor subfamily 2, group f, member 1, RASD1 - ras, dexamethasone-induced 1, ZFYVE26 - zinc finger, fyve domain containing 26, ST8SIA1 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1, RBM24 - rna binding motif protein 24, SNCAIP - synuclein, alpha interacting protein, GRIA3 - glutamate receptor, ionotropic, ampa 3, TPP1 - tripeptidyl peptidase i, TGFBR1 - transforming growth factor, beta receptor 1, MARCKS - myristoylated alanine-rich protein kinase c substrate, SEZ6L - seizure related 6 homolog (mouse)-like, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, GPCPD1 - glycerophosphocholine phosphodiesterase gde1 homolog (s. cerevisiae), TRIM45 - tripartite motif containing 45, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, TP53INP1 - tumor protein p53 inducible nuclear protein 1, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, NBR1 - neighbor of brca1 gene 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, SPATA13 - spermatogenesis associated 13, CYR61 - cysteine-rich, angiogenic inducer, 61, CACHD1 - cache domain containing 1, THBS4 - thrombospondin 4, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, CCBL2 - cysteine conjugate-beta lyase 2, MGAT4A - mannosyl (alpha-1,3-)-glycoprotein beta-1,4-n-acetylglucosaminyltransferase, isozyme a, KAT6B - k(lysine) acetyltransferase 6b, SGK1 - serum/glucocorticoid regulated kinase 1, BCHE - butyrylcholinesterase, NECAB3 - n-terminal ef-hand calcium binding protein 3, AK3 - adenylate kinase 3, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, PCDH18 - protocadherin 18, SH3GL2 - sh3-domain grb2-like 2]" GO:0071407 cellular response to organic cyclic compound 6.60E-05 6.19E-03 2.53 16376 260 548 22 "[IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, AKAP7 - a kinase (prka) anchor protein 7, RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, EGR3 - early growth response 3, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, EGR1 - early growth response 1, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NR2F1 - nuclear receptor subfamily 2, group f, member 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, GPER1 - g protein-coupled estrogen receptor 1, ANXA1 - annexin a1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2, KLF5 - kruppel-like factor 5 (intestinal), BMP7 - bone morphogenetic protein 7]" GO:0050680 negative regulation of epithelial cell proliferation 6.86E-05 6.39E-03 3.81 16376 94 548 12 "[TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, PAX6 - paired box 6, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, GAS1 - growth arrest-specific 1, APC - adenomatous polyposis coli]" GO:0001101 response to acid 6.99E-05 6.46E-03 2.52 16376 261 548 22 "[MAP7 - microtubule-associated protein 7, RORB - rar-related orphan receptor b, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), GSN - gelsolin, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), S100A10 - s100 calcium binding protein a10, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, KLF4 - kruppel-like factor 4 (gut), EGR1 - early growth response 1, CTGF - connective tissue growth factor, FZD7 - frizzled family receptor 7, PDGFD - platelet derived growth factor d, DKK1 - dickkopf wnt signaling pathway inhibitor 1, CD9 - cd9 molecule, DUSP1 - dual specificity phosphatase 1, BCHE - butyrylcholinesterase, INSIG2 - insulin induced gene 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1]" GO:0045937 positive regulation of phosphate metabolic process 7.16E-05 6.52E-03 1.79 16376 803 548 48 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, ACVR2A - activin a receptor, type iia, SDCBP - syndecan binding protein (syntenin), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, ACKR3 - atypical chemokine receptor 3, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, ADM - adrenomedullin, GPER1 - g protein-coupled estrogen receptor 1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0019220 regulation of phosphate metabolic process 7.23E-05 6.53E-03 1.51 16376 1685 548 85 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, PIFO - primary cilia formation, EPS8L1 - eps8-like 1, ACKR3 - atypical chemokine receptor 3, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, DUSP1 - dual specificity phosphatase 1, CCNL1 - cyclin l1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, INSM1 - insulinoma-associated 1, EPHB1 - eph receptor b1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, S100A10 - s100 calcium binding protein a10, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, TBC1D8 - tbc1 domain family, member 8 (with gram domain), THBS4 - thrombospondin 4, PDE2A - phosphodiesterase 2a, cgmp-stimulated, ADM - adrenomedullin, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, ARHGAP9 - rho gtpase activating protein 9, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0010562 positive regulation of phosphorus metabolic process 7.16E-05 6.57E-03 1.79 16376 803 548 48 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, ACVR2A - activin a receptor, type iia, SDCBP - syndecan binding protein (syntenin), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, ACKR3 - atypical chemokine receptor 3, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, ADM - adrenomedullin, GPER1 - g protein-coupled estrogen receptor 1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger 7.80E-05 7.00E-03 14.94 16376 8 548 4 "[FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), FZD6 - frizzled family receptor 6, FZD2 - frizzled family receptor 2]" GO:0033993 response to lipid 7.87E-05 7.01E-03 1.9 16376 629 548 40 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, MAP7 - microtubule-associated protein 7, TIMP4 - timp metallopeptidase inhibitor 4, JUND - jun d proto-oncogene, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, CTGF - connective tissue growth factor, EGR1 - early growth response 1, FZD7 - frizzled family receptor 7, NR2F1 - nuclear receptor subfamily 2, group f, member 1, DKK1 - dickkopf wnt signaling pathway inhibitor 1, INSIG2 - insulin induced gene 2, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, TGFBR1 - transforming growth factor, beta receptor 1, ACSBG1 - acyl-coa synthetase bubblegum family member 1, RORB - rar-related orphan receptor b, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PELI1 - pellino e3 ubiquitin protein ligase 1, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), FOSB - fbj murine osteosarcoma viral oncogene homolog b, FOS - fbj murine osteosarcoma viral oncogene homolog, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, ADM - adrenomedullin, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, BCHE - butyrylcholinesterase, F2R - coagulation factor ii (thrombin) receptor, NR4A1 - nuclear receptor subfamily 4, group a, member 1, NR1D2 - nuclear receptor subfamily 1, group d, member 2, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, DUSP10 - dual specificity phosphatase 10, MGST2 - microsomal glutathione s-transferase 2, BMP7 - bone morphogenetic protein 7]" GO:0043068 positive regulation of programmed cell death 8.03E-05 7.11E-03 2.21 16376 379 548 28 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, FGFR3 - fibroblast growth factor receptor 3, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, EGR1 - early growth response 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, GADD45G - growth arrest and dna-damage-inducible, gamma, TP53INP1 - tumor protein p53 inducible nuclear protein 1, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, CYR61 - cysteine-rich, angiogenic inducer, 61, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, ADM - adrenomedullin, AKAP13 - a kinase (prka) anchor protein 13, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7]" GO:0023057 negative regulation of signaling 8.92E-05 7.84E-03 1.76 16376 833 548 49 "[TIMP2 - timp metallopeptidase inhibitor 2, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, APC - adenomatous polyposis coli, DACT3 - dishevelled-binding antagonist of beta-catenin 3, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, ELF1 - e74-like factor 1 (ets domain transcription factor), DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, CREBRF - creb3 regulatory factor, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SPRY2 - sprouty homolog 2 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, BCHE - butyrylcholinesterase, FBN2 - fibrillin 2, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0045859 regulation of protein kinase activity 9.07E-05 7.85E-03 1.87 16376 655 548 41 "[PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, LRP6 - low density lipoprotein receptor-related protein 6, CCNG1 - cyclin g1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, ERRFI1 - erbb receptor feedback inhibitor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, EPHA4 - eph receptor a4, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, AKAP13 - a kinase (prka) anchor protein 13, CCNL1 - cyclin l1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0048729 tissue morphogenesis 9.02E-05 7.86E-03 2.27 16376 342 548 26 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HES5 - hairy and enhancer of split 5 (drosophila), PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, FREM2 - fras1 related extracellular matrix protein 2, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, DLL1 - delta-like 1 (drosophila), NOTCH4 - notch 4, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), PCDH8 - protocadherin 8, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, NRARP - notch-regulated ankyrin repeat protein, SPRY2 - sprouty homolog 2 (drosophila), KLF4 - kruppel-like factor 4 (gut), EYA1 - eyes absent homolog 1 (drosophila), ADM - adrenomedullin, BMP7 - bone morphogenetic protein 7]" GO:0051174 regulation of phosphorus metabolic process 9.43E-05 8.11E-03 1.5 16376 1698 548 85 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, PIFO - primary cilia formation, EPS8L1 - eps8-like 1, ACKR3 - atypical chemokine receptor 3, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, DUSP1 - dual specificity phosphatase 1, CCNL1 - cyclin l1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DOCK10 - dedicator of cytokinesis 10, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, ATXN1 - ataxin 1, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CCNG1 - cyclin g1, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, INSM1 - insulinoma-associated 1, EPHB1 - eph receptor b1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, S100A10 - s100 calcium binding protein a10, CLIP3 - cap-gly domain containing linker protein 3, NBR1 - neighbor of brca1 gene 1, KLF4 - kruppel-like factor 4 (gut), BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, TBC1D8 - tbc1 domain family, member 8 (with gram domain), THBS4 - thrombospondin 4, PDE2A - phosphodiesterase 2a, cgmp-stimulated, ADM - adrenomedullin, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, ARHGAP9 - rho gtpase activating protein 9, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0010648 negative regulation of cell communication 9.74E-05 8.26E-03 1.75 16376 836 548 49 "[TIMP2 - timp metallopeptidase inhibitor 2, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), ANKRD6 - ankyrin repeat domain 6, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, APC - adenomatous polyposis coli, DACT3 - dishevelled-binding antagonist of beta-catenin 3, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NRARP - notch-regulated ankyrin repeat protein, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EYA1 - eyes absent homolog 1 (drosophila), ACKR3 - atypical chemokine receptor 3, ELF1 - e74-like factor 1 (ets domain transcription factor), DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD6 - frizzled family receptor 6, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, CREBRF - creb3 regulatory factor, TGFBR1 - transforming growth factor, beta receptor 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SPRY2 - sprouty homolog 2 (drosophila), PPP1R15A - protein phosphatase 1, regulatory subunit 15a, TGIF1 - tgfb-induced factor homeobox 1, DAPK1 - death-associated protein kinase 1, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), SULF2 - sulfatase 2, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, BCHE - butyrylcholinesterase, FBN2 - fibrillin 2, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:1902533 positive regulation of intracellular signal transduction 9.69E-05 8.28E-03 1.86 16376 657 548 41 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, KIAA1161 - kiaa1161, TRIM62 - tripartite motif containing 62, SDCBP - syndecan binding protein (syntenin), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, DFNA5 - deafness, autosomal dominant 5, S100A4 - s100 calcium binding protein a4, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BCL10 - b-cell cll/lymphoma 10, ACKR3 - atypical chemokine receptor 3, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, GPER1 - g protein-coupled estrogen receptor 1, CSPG4 - chondroitin sulfate proteoglycan 4, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0040011 locomotion 1.03E-04 8.55E-03 1.79 16376 770 548 46 "[SCG2 - secretogranin ii, FN1 - fibronectin 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, F11R - f11 receptor, PAX6 - paired box 6, RGR - retinal g protein coupled receptor, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, ARID5B - at rich interactive domain 5b (mrf1-like), RFX3 - regulatory factor x, 3 (influences hla class ii expression), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, DCX - doublecortin, CTGF - connective tissue growth factor, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, NR2F1 - nuclear receptor subfamily 2, group f, member 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, TGFBR1 - transforming growth factor, beta receptor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, EPHB1 - eph receptor b1, EGR3 - early growth response 3, ZEB2 - zinc finger e-box binding homeobox 2, SLIT1 - slit homolog 1 (drosophila), EPHA4 - eph receptor a4, PLXNA2 - plexin a2, BAMBI - bmp and activin membrane-bound inhibitor, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, ACKR3 - atypical chemokine receptor 3, CXCL2 - chemokine (c-x-c motif) ligand 2, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, CSPG4 - chondroitin sulfate proteoglycan 4, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, VCAN - versican, ZFAND5 - zinc finger, an1-type domain 5, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0016477 cell migration 1.03E-04 8.58E-03 1.9 16376 615 548 39 "[SCG2 - secretogranin ii, FN1 - fibronectin 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, F11R - f11 receptor, PAX6 - paired box 6, ARID5B - at rich interactive domain 5b (mrf1-like), LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, DCX - doublecortin, CTGF - connective tissue growth factor, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, TGFBR1 - transforming growth factor, beta receptor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, EPHB1 - eph receptor b1, EGR3 - early growth response 3, ZEB2 - zinc finger e-box binding homeobox 2, EPHA4 - eph receptor a4, PLXNA2 - plexin a2, BAMBI - bmp and activin membrane-bound inhibitor, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, CXCL2 - chemokine (c-x-c motif) ligand 2, THBS4 - thrombospondin 4, CSPG4 - chondroitin sulfate proteoglycan 4, FYN - fyn oncogene related to src, fgr, yes, VCAN - versican, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZFAND5 - zinc finger, an1-type domain 5]" GO:0003002 regionalization 1.02E-04 8.63E-03 2.59 16376 231 548 20 "[TGFBR1 - transforming growth factor, beta receptor 1, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, INTU - inturned planar cell polarity protein, ACVR2A - activin a receptor, type iia, PAX6 - paired box 6, ZEB2 - zinc finger e-box binding homeobox 2, IRX1 - iroquois homeobox 1, PTCH1 - patched 1, TGIF1 - tgfb-induced factor homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, SP8 - sp8 transcription factor, PLXNA2 - plexin a2, DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), PBX1 - pre-b-cell leukemia homeobox 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, EN1 - engrailed homeobox 1, GAS1 - growth arrest-specific 1, APC - adenomatous polyposis coli, PCDH8 - protocadherin 8]" GO:0051960 regulation of nervous system development 1.07E-04 8.81E-03 2 16376 509 548 34 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, RUFY3 - run and fyve domain containing 3, PAX6 - paired box 6, LRP6 - low density lipoprotein receptor-related protein 6, DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), EPHB1 - eph receptor b1, SLIT1 - slit homolog 1 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, PTPRD - protein tyrosine phosphatase, receptor type, d, FYN - fyn oncogene related to src, fgr, yes, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0045668 negative regulation of osteoblast differentiation 1.11E-04 9.02E-03 6.15 16376 34 548 7 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, TWIST1 - twist basic helix-loop-helix transcription factor 1, RORB - rar-related orphan receptor b, PTCH1 - patched 1, HDAC5 - histone deacetylase 5, NBR1 - neighbor of brca1 gene 1]" GO:0009968 negative regulation of signal transduction 1.11E-04 9.08E-03 1.77 16376 795 548 47 "[TIMP2 - timp metallopeptidase inhibitor 2, SCG2 - secretogranin ii, FGFR3 - fibroblast growth factor receptor 3, ATXN1 - ataxin 1, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), EGR1 - early growth response 1, ANKRD6 - ankyrin repeat domain 6, TWIST1 - twist basic helix-loop-helix transcription factor 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), FZD6 - frizzled family receptor 6, DKK1 - dickkopf wnt signaling pathway inhibitor 1, ADA - adenosine deaminase, MAP2K5 - mitogen-activated protein kinase kinase 5, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, CD109 - cd109 molecule, CREBRF - creb3 regulatory factor, TGFBR1 - transforming growth factor, beta receptor 1, ERRFI1 - erbb receptor feedback inhibitor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NRARP - notch-regulated ankyrin repeat protein, SPRY2 - sprouty homolog 2 (drosophila), TGIF1 - tgfb-induced factor homeobox 1, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, BAMBI - bmp and activin membrane-bound inhibitor, DAPK1 - death-associated protein kinase 1, KLF4 - kruppel-like factor 4 (gut), SULF2 - sulfatase 2, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), ELF1 - e74-like factor 1 (ets domain transcription factor), DUSP1 - dual specificity phosphatase 1, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, FBN2 - fibrillin 2, DUSP10 - dual specificity phosphatase 10, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2, BMP7 - bone morphogenetic protein 7]" GO:0009605 response to external stimulus 1.12E-04 9.09E-03 1.59 16376 1240 548 66 "[IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, TIMP4 - timp metallopeptidase inhibitor 4, HIST2H2BE - histone cluster 2, h2be, PTX3 - pentraxin 3, long, RGR - retinal g protein coupled receptor, GSN - gelsolin, ATP1A2 - atpase, na+/k+ transporting, alpha 2 polypeptide, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), RPE65 - retinal pigment epithelium-specific protein 65kda, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, RLBP1 - retinaldehyde binding protein 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, FOXP2 - forkhead box p2, ACKR3 - atypical chemokine receptor 3, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, IFIH1 - interferon induced with helicase c domain 1, F2R - coagulation factor ii (thrombin) receptor, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, TRIM22 - tripartite motif containing 22, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, JUND - jun d proto-oncogene, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CORO1B - coronin, actin binding protein, 1b, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, ADA - adenosine deaminase, ETV1 - ets variant 1, GPC4 - glypican 4, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, SLIT1 - slit homolog 1 (drosophila), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), BCL10 - b-cell cll/lymphoma 10, NBR1 - neighbor of brca1 gene 1, FOSB - fbj murine osteosarcoma viral oncogene homolog b, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, FOS - fbj murine osteosarcoma viral oncogene homolog, CXCL2 - chemokine (c-x-c motif) ligand 2, CYR61 - cysteine-rich, angiogenic inducer, 61, PDE2A - phosphodiesterase 2a, cgmp-stimulated, SATB1 - satb homeobox 1, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ADM - adrenomedullin, BCHE - butyrylcholinesterase, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide, NR4A1 - nuclear receptor subfamily 4, group a, member 1, MGST2 - microsomal glutathione s-transferase 2]" GO:0097485 neuron projection guidance 1.31E-04 1.05E-02 2.22 16376 350 548 26 "[CXCR4 - chemokine (c-x-c motif) receptor 4, PAX6 - paired box 6, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, ETV1 - ets variant 1, CHL1 - cell adhesion molecule l1-like, NCAM1 - neural cell adhesion molecule 1, RUNX3 - runt-related transcription factor 3, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), MYO10 - myosin x, COL9A3 - collagen, type ix, alpha 3, EPHB1 - eph receptor b1, SLIT1 - slit homolog 1 (drosophila), PLXNA2 - plexin a2, EPHA4 - eph receptor a4, BOC - boc cell adhesion associated, oncogene regulated, ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, SPON2 - spondin 2, extracellular matrix protein, FYN - fyn oncogene related to src, fgr, yes, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0007411 axon guidance 1.31E-04 1.05E-02 2.22 16376 350 548 26 "[CXCR4 - chemokine (c-x-c motif) receptor 4, PAX6 - paired box 6, SDCBP - syndecan binding protein (syntenin), DCX - doublecortin, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, ETV1 - ets variant 1, CHL1 - cell adhesion molecule l1-like, NCAM1 - neural cell adhesion molecule 1, RUNX3 - runt-related transcription factor 3, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), MYO10 - myosin x, COL9A3 - collagen, type ix, alpha 3, EPHB1 - eph receptor b1, SLIT1 - slit homolog 1 (drosophila), PLXNA2 - plexin a2, EPHA4 - eph receptor a4, BOC - boc cell adhesion associated, oncogene regulated, ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, SPON2 - spondin 2, extracellular matrix protein, FYN - fyn oncogene related to src, fgr, yes, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0001656 metanephros development 1.35E-04 1.07E-02 5.98 16376 35 548 7 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, EGR1 - early growth response 1, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, EYA1 - eyes absent homolog 1 (drosophila), OSR2 - odd-skipped related 2 (drosophila), BMP7 - bone morphogenetic protein 7]" GO:0048870 cell motility 1.48E-04 1.17E-02 1.83 16376 670 548 41 "[SCG2 - secretogranin ii, FN1 - fibronectin 1, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, F11R - f11 receptor, PAX6 - paired box 6, JMY - junction mediating and regulatory protein, p53 cofactor, ARID5B - at rich interactive domain 5b (mrf1-like), LRP6 - low density lipoprotein receptor-related protein 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, DCX - doublecortin, CTGF - connective tissue growth factor, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, APC - adenomatous polyposis coli, TGFBR1 - transforming growth factor, beta receptor 1, APCDD1 - adenomatosis polyposis coli down-regulated 1, EPHB1 - eph receptor b1, EGR3 - early growth response 3, ZEB2 - zinc finger e-box binding homeobox 2, EPHA4 - eph receptor a4, PLXNA2 - plexin a2, BAMBI - bmp and activin membrane-bound inhibitor, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, SPATA13 - spermatogenesis associated 13, CYR61 - cysteine-rich, angiogenic inducer, 61, CXCL2 - chemokine (c-x-c motif) ligand 2, THBS4 - thrombospondin 4, CSPG4 - chondroitin sulfate proteoglycan 4, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, VCAN - versican, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZFAND5 - zinc finger, an1-type domain 5]" GO:0080134 regulation of response to stress 1.49E-04 1.17E-02 1.71 16376 874 548 50 "[A2M - alpha-2-macroglobulin, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, CAPN3 - calpain 3, (p94), SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, STXBP5 - syntaxin binding protein 5 (tomosyn), ANKRD6 - ankyrin repeat domain 6, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CD109 - cd109 molecule, APOBEC3G - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3g, PIAS1 - protein inhibitor of activated stat, 1, CTSK - cathepsin k, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, ACKR3 - atypical chemokine receptor 3, EYA1 - eyes absent homolog 1 (drosophila), APOBEC3F - apolipoprotein b mrna editing enzyme, catalytic polypeptide-like 3f, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, IFIH1 - interferon induced with helicase c domain 1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, SESN3 - sestrin 3, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD7 - frizzled family receptor 7, ADA - adenosine deaminase, MAP2K6 - mitogen-activated protein kinase kinase 6, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, CREBRF - creb3 regulatory factor, MAPK10 - mitogen-activated protein kinase 10, EPHB1 - eph receptor b1, PELI1 - pellino e3 ubiquitin protein ligase 1, ZEB2 - zinc finger e-box binding homeobox 2, FAM175A - family with sequence similarity 175, member a, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), NBR1 - neighbor of brca1 gene 1, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, ANXA1 - annexin a1, NR1D2 - nuclear receptor subfamily 1, group d, member 2]" GO:0043069 negative regulation of programmed cell death 1.58E-04 1.23E-02 1.86 16376 628 548 39 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, SCG2 - secretogranin ii, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAPN3 - calpain 3, (p94), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, LRP6 - low density lipoprotein receptor-related protein 6, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, CHL1 - cell adhesion molecule l1-like, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), CBX4 - chromobox homolog 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, DHRS2 - dehydrogenase/reductase (sdr family) member 2, TSC22D3 - tsc22 domain family, member 3, ANXA1 - annexin a1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, GAS1 - growth arrest-specific 1, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7]" GO:0050767 regulation of neurogenesis 1.63E-04 1.26E-02 2.03 16376 457 548 31 "[CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, RUFY3 - run and fyve domain containing 3, FGFR3 - fibroblast growth factor receptor 3, PAX6 - paired box 6, DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), SLIT1 - slit homolog 1 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, GPER1 - g protein-coupled estrogen receptor 1, PTPRD - protein tyrosine phosphatase, receptor type, d, FYN - fyn oncogene related to src, fgr, yes, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0006928 cellular component movement 1.72E-04 1.32E-02 1.59 16376 1186 548 63 "[TTC21B - tetratricopeptide repeat domain 21b, FN1 - fibronectin 1, F11R - f11 receptor, PAX6 - paired box 6, ARID5B - at rich interactive domain 5b (mrf1-like), RFX3 - regulatory factor x, 3 (influences hla class ii expression), SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, DCX - doublecortin, SUN2 - sad1 and unc84 domain containing 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, CHL1 - cell adhesion molecule l1-like, BTG1 - b-cell translocation gene 1, anti-proliferative, NCAM1 - neural cell adhesion molecule 1, APC - adenomatous polyposis coli, APCDD1 - adenomatosis polyposis coli down-regulated 1, MYO10 - myosin x, EGR3 - early growth response 3, PLXNA2 - plexin a2, ST8SIA4 - st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 4, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, IGSF8 - immunoglobulin superfamily, member 8, JMY - junction mediating and regulatory protein, p53 cofactor, LRP6 - low density lipoprotein receptor-related protein 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, NR2F1 - nuclear receptor subfamily 2, group f, member 1, CD9 - cd9 molecule, ETV1 - ets variant 1, TGFBR1 - transforming growth factor, beta receptor 1, RUNX3 - runt-related transcription factor 3, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), COL9A3 - collagen, type ix, alpha 3, EPHB1 - eph receptor b1, ZEB2 - zinc finger e-box binding homeobox 2, SLIT1 - slit homolog 1 (drosophila), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, BOC - boc cell adhesion associated, oncogene regulated, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CXCL2 - chemokine (c-x-c motif) ligand 2, SPATA13 - spermatogenesis associated 13, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, ANXA1 - annexin a1, SPON2 - spondin 2, extracellular matrix protein, CSPG4 - chondroitin sulfate proteoglycan 4, VCAN - versican, ZFAND5 - zinc finger, an1-type domain 5, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0010470 regulation of gastrulation 1.78E-04 1.36E-02 6.9 16376 26 548 6 "[FZD7 - frizzled family receptor 7, DKK1 - dickkopf wnt signaling pathway inhibitor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, OSR2 - odd-skipped related 2 (drosophila), TGIF1 - tgfb-induced factor homeobox 1, KLF4 - kruppel-like factor 4 (gut)]" GO:0007409 axonogenesis 1.84E-04 1.39E-02 3.45 16376 104 548 12 "[DCX - doublecortin, FZD7 - frizzled family receptor 7, CDH11 - cadherin 11, type 2, ob-cadherin (osteoblast), FZD6 - frizzled family receptor 6, MAP2 - microtubule-associated protein 2, FGFR3 - fibroblast growth factor receptor 3, EPHB1 - eph receptor b1, S100A6 - s100 calcium binding protein a6, ATL1 - atlastin gtpase 1, EPHA4 - eph receptor a4, APC - adenomatous polyposis coli, FZD2 - frizzled family receptor 2]" GO:0030855 epithelial cell differentiation 1.94E-04 1.46E-02 2.35 16376 280 548 22 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, HES5 - hairy and enhancer of split 5 (drosophila), KLF15 - kruppel-like factor 15, PROX1 - prospero homeobox 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, INSM1 - insulinoma-associated 1, PAX6 - paired box 6, F11R - f11 receptor, PTCH1 - patched 1, KLF2 - kruppel-like factor 2 (lung), KLF4 - kruppel-like factor 4 (gut), BDH2 - 3-hydroxybutyrate dehydrogenase, type 2, EYA1 - eyes absent homolog 1 (drosophila), JAG1 - jagged 1, ANXA1 - annexin a1, GPSM2 - g-protein signaling modulator 2, TPP1 - tripeptidyl peptidase i, BMP7 - bone morphogenetic protein 7, FZD2 - frizzled family receptor 2]" GO:0043410 positive regulation of MAPK cascade 2.06E-04 1.54E-02 2.2 16376 340 548 25 "[TIMP2 - timp metallopeptidase inhibitor 2, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, SDCBP - syndecan binding protein (syntenin), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, CTGF - connective tissue growth factor, ANKRD6 - ankyrin repeat domain 6, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, MAPK10 - mitogen-activated protein kinase 10, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, ACKR3 - atypical chemokine receptor 3, GPER1 - g protein-coupled estrogen receptor 1, CSPG4 - chondroitin sulfate proteoglycan 4, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0051642 centrosome localization 2.22E-04 1.65E-02 11.95 16376 10 548 4 "[SUN2 - sad1 and unc84 domain containing 2, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, NIN - ninein (gsk3b interacting protein), PLXNA2 - plexin a2]" GO:0001709 cell fate determination 2.31E-04 1.72E-02 5.5 16376 38 548 7 "[NOTCH4 - notch 4, HES5 - hairy and enhancer of split 5 (drosophila), JAG1 - jagged 1, PROX1 - prospero homeobox 1, PAX6 - paired box 6, KLF4 - kruppel-like factor 4 (gut), DLL1 - delta-like 1 (drosophila)]" GO:1901653 cellular response to peptide 2.40E-04 1.77E-02 2.37 16376 265 548 21 "[KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, KLF2 - kruppel-like factor 2 (lung), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), KLF4 - kruppel-like factor 4 (gut), EGR1 - early growth response 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, ADCY8 - adenylate cyclase 8 (brain), RPE65 - retinal pigment epithelium-specific protein 65kda, KAT2B - k(lysine) acetyltransferase 2b, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), ADCY2 - adenylate cyclase 2 (brain)]" GO:0043066 negative regulation of apoptotic process 2.42E-04 1.77E-02 1.83 16376 619 548 38 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, SCG2 - secretogranin ii, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAPN3 - calpain 3, (p94), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, LRP6 - low density lipoprotein receptor-related protein 6, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, CHL1 - cell adhesion molecule l1-like, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, CBX4 - chromobox homolog 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, DHRS2 - dehydrogenase/reductase (sdr family) member 2, TSC22D3 - tsc22 domain family, member 3, ANXA1 - annexin a1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, GAS1 - growth arrest-specific 1, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7]" GO:0060548 negative regulation of cell death 2.54E-04 1.85E-02 1.8 16376 665 548 40 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, IFIT3 - interferon-induced protein with tetratricopeptide repeats 3, SCG2 - secretogranin ii, BNIP3L - bcl2/adenovirus e1b 19kda interacting protein 3-like, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, CAPN3 - calpain 3, (p94), MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, LRP6 - low density lipoprotein receptor-related protein 6, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, EGR1 - early growth response 1, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, CHL1 - cell adhesion molecule l1-like, IL31RA - interleukin 31 receptor a, TGFBR1 - transforming growth factor, beta receptor 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EGR3 - early growth response 3, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), CBX4 - chromobox homolog 4, NR4A3 - nuclear receptor subfamily 4, group a, member 3, DHRS2 - dehydrogenase/reductase (sdr family) member 2, TSC22D3 - tsc22 domain family, member 3, ANXA1 - annexin a1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, GAS1 - growth arrest-specific 1, TSC22D1 - tsc22 domain family, member 1, BMP7 - bone morphogenetic protein 7]" GO:0071901 negative regulation of protein serine/threonine kinase activity 2.62E-04 1.90E-02 3.32 16376 108 548 12 "[DUSP4 - dual specificity phosphatase 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, DUSP1 - dual specificity phosphatase 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), LRP6 - low density lipoprotein receptor-related protein 6, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, APC - adenomatous polyposis coli, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, BMP7 - bone morphogenetic protein 7]" GO:0051246 regulation of protein metabolic process 2.73E-04 1.97E-02 1.44 16376 1829 548 88 "[HES5 - hairy and enhancer of split 5 (drosophila), A2M - alpha-2-macroglobulin, TIMP2 - timp metallopeptidase inhibitor 2, TIMP4 - timp metallopeptidase inhibitor 4, FN1 - fibronectin 1, PAIP1 - poly(a) binding protein interacting protein 1, CAPN3 - calpain 3, (p94), PTX3 - pentraxin 3, long, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), TRPS1 - trichorhinophalangeal syndrome i, DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, DUSP4 - dual specificity phosphatase 4, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, DUSP1 - dual specificity phosphatase 1, CCNL1 - cyclin l1, FYN - fyn oncogene related to src, fgr, yes, F2R - coagulation factor ii (thrombin) receptor, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, KLF15 - kruppel-like factor 15, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), CCNG1 - cyclin g1, AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, IL31RA - interleukin 31 receptor a, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TPP1 - tripeptidyl peptidase i, CREBRF - creb3 regulatory factor, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PELI1 - pellino e3 ubiquitin protein ligase 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PELI2 - pellino e3 ubiquitin protein ligase family member 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, EPHA4 - eph receptor a4, DAPK1 - death-associated protein kinase 1, CLIP3 - cap-gly domain containing linker protein 3, KLF4 - kruppel-like factor 4 (gut), BCL10 - b-cell cll/lymphoma 10, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, NECAB3 - n-terminal ef-hand calcium binding protein 3, NR4A1 - nuclear receptor subfamily 4, group a, member 1, GAS1 - growth arrest-specific 1, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0030334 regulation of cell migration 2.76E-04 1.98E-02 1.97 16376 471 548 31 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, PAX6 - paired box 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, SUN2 - sad1 and unc84 domain containing 2, HAS2 - hyaluronan synthase 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, MAP2K5 - mitogen-activated protein kinase kinase 5, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PLXNA2 - plexin a2, KLF4 - kruppel-like factor 4 (gut), CYR61 - cysteine-rich, angiogenic inducer, 61, SPATA13 - spermatogenesis associated 13, THBS4 - thrombospondin 4, DACH1 - dachshund homolog 1 (drosophila), GPER1 - g protein-coupled estrogen receptor 1, SGK1 - serum/glucocorticoid regulated kinase 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DOCK10 - dedicator of cytokinesis 10]" GO:0007219 Notch signaling pathway 2.85E-04 2.03E-02 3.11 16376 125 548 13 "[HES5 - hairy and enhancer of split 5 (drosophila), MAML3 - mastermind-like 3 (drosophila), HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), DLL3 - delta-like 3 (drosophila), DLL1 - delta-like 1 (drosophila), DTX4 - deltex homolog 4 (drosophila), NOTCH4 - notch 4, TLE4 - transducin-like enhancer of split 4 (e(sp1) homolog, drosophila), TFDP2 - transcription factor dp-2 (e2f dimerization partner 2), JAG1 - jagged 1, KAT2B - k(lysine) acetyltransferase 2b, HDAC5 - histone deacetylase 5]" GO:0060021 palate development 2.97E-04 2.06E-02 4.14 16376 65 548 9 "[TIPARP - tcdd-inducible poly(adp-ribose) polymerase, TGFBR1 - transforming growth factor, beta receptor 1, TWIST1 - twist basic helix-loop-helix transcription factor 1, OSR2 - odd-skipped related 2 (drosophila), INSIG2 - insulin induced gene 2, LRP6 - low density lipoprotein receptor-related protein 6, ARID5B - at rich interactive domain 5b (mrf1-like), GAS1 - growth arrest-specific 1, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide]" GO:0009798 axis specification 2.97E-04 2.07E-02 4.14 16376 65 548 9 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, PAX6 - paired box 6, NRARP - notch-regulated ankyrin repeat protein, PTCH1 - patched 1, CXXC4 - cxxc finger protein 4, APC - adenomatous polyposis coli, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), DLL1 - delta-like 1 (drosophila)]" GO:0001843 neural tube closure 2.97E-04 2.09E-02 4.14 16376 65 548 9 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD6 - frizzled family receptor 6, ADM - adrenomedullin, ZEB2 - zinc finger e-box binding homeobox 2, PTCH1 - patched 1, TGIF1 - tgfb-induced factor homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, BCL10 - b-cell cll/lymphoma 10]" GO:0071417 cellular response to organonitrogen compound 2.95E-04 2.09E-02 2.07 16376 389 548 27 "[KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, PDGFD - platelet derived growth factor d, ADCY8 - adenylate cyclase 8 (brain), RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), ADCY2 - adenylate cyclase 2 (brain), AKAP7 - a kinase (prka) anchor protein 7, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EGR3 - early growth response 3, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b]" GO:2000145 regulation of cell motility 3.04E-04 2.10E-02 1.93 16376 495 548 32 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, PAX6 - paired box 6, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, SUN2 - sad1 and unc84 domain containing 2, HAS2 - hyaluronan synthase 2, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), ENPP2 - ectonucleotide pyrophosphatase/phosphodiesterase 2, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADA - adenosine deaminase, SEMA6A - sema domain, transmembrane domain (tm), and cytoplasmic domain, (semaphorin) 6a, MAP2K5 - mitogen-activated protein kinase kinase 5, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, TP53INP1 - tumor protein p53 inducible nuclear protein 1, PLXNA2 - plexin a2, KLF4 - kruppel-like factor 4 (gut), SPATA13 - spermatogenesis associated 13, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, DACH1 - dachshund homolog 1 (drosophila), GPER1 - g protein-coupled estrogen receptor 1, SGK1 - serum/glucocorticoid regulated kinase 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, DOCK10 - dedicator of cytokinesis 10]" GO:0060606 tube closure 3.33E-04 2.29E-02 4.07 16376 66 548 9 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, TWIST1 - twist basic helix-loop-helix transcription factor 1, FZD6 - frizzled family receptor 6, ADM - adrenomedullin, ZEB2 - zinc finger e-box binding homeobox 2, PTCH1 - patched 1, TGIF1 - tgfb-induced factor homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, BCL10 - b-cell cll/lymphoma 10]" GO:0097150 neuronal stem cell maintenance 3.39E-04 2.31E-02 10.87 16376 11 548 4 "[HES5 - hairy and enhancer of split 5 (drosophila), JAG1 - jagged 1, PROX1 - prospero homeobox 1, DLL1 - delta-like 1 (drosophila)]" GO:0071498 cellular response to fluid shear stress 3.39E-04 2.32E-02 10.87 16376 11 548 4 "[HAS2 - hyaluronan synthase 2, MAP2K5 - mitogen-activated protein kinase kinase 5, KLF2 - kruppel-like factor 2 (lung), KLF4 - kruppel-like factor 4 (gut)]" GO:1901699 cellular response to nitrogen compound 3.50E-04 2.35E-02 2.02 16376 414 548 28 "[IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, KLF15 - kruppel-like factor 15, FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, KLF2 - kruppel-like factor 2 (lung), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, PDGFD - platelet derived growth factor d, ADCY8 - adenylate cyclase 8 (brain), RPE65 - retinal pigment epithelium-specific protein 65kda, HDAC5 - histone deacetylase 5, KLF5 - kruppel-like factor 5 (intestinal), ADCY2 - adenylate cyclase 2 (brain), AKAP7 - a kinase (prka) anchor protein 7, GNG2 - guanine nucleotide binding protein (g protein), gamma 2, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, EGR3 - early growth response 3, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, UCP2 - uncoupling protein 2 (mitochondrial, proton carrier), KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, PDE2A - phosphodiesterase 2a, cgmp-stimulated, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, FYN - fyn oncogene related to src, fgr, yes, KAT2B - k(lysine) acetyltransferase 2b]" GO:0033674 positive regulation of kinase activity 3.48E-04 2.35E-02 1.97 16376 456 548 30 "[PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, EPHA4 - eph receptor a4, PIFO - primary cilia formation, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, F2R - coagulation factor ii (thrombin) receptor, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0022603 regulation of anatomical structure morphogenesis 3.64E-04 2.44E-02 1.77 16376 677 548 40 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, FN1 - fibronectin 1, PROX1 - prospero homeobox 1, RUFY3 - run and fyve domain containing 3, LRP6 - low density lipoprotein receptor-related protein 6, CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), FZD7 - frizzled family receptor 7, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), FZD6 - frizzled family receptor 6, DKK1 - dickkopf wnt signaling pathway inhibitor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, BTG1 - b-cell translocation gene 1, anti-proliferative, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, HDAC5 - histone deacetylase 5, APC - adenomatous polyposis coli, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), MYO10 - myosin x, FGD3 - fyve, rhogef and ph domain containing 3, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, NRARP - notch-regulated ankyrin repeat protein, SLIT1 - slit homolog 1 (drosophila), TGIF1 - tgfb-induced factor homeobox 1, FOXP2 - forkhead box p2, EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, S100A10 - s100 calcium binding protein a10, KLF4 - kruppel-like factor 4 (gut), EYA1 - eyes absent homolog 1 (drosophila), THBS4 - thrombospondin 4, ADM - adrenomedullin, PTPRD - protein tyrosine phosphatase, receptor type, d, FYN - fyn oncogene related to src, fgr, yes, OSR2 - odd-skipped related 2 (drosophila), FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7]" GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 3.69E-04 2.46E-02 1.87 16376 544 548 34 "[FGFR3 - fibroblast growth factor receptor 3, CAB39L - calcium binding protein 39-like, ARID5B - at rich interactive domain 5b (mrf1-like), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), CTGF - connective tissue growth factor, GAB2 - grb2-associated binding protein 2, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, ADCY8 - adenylate cyclase 8 (brain), RPE65 - retinal pigment epithelium-specific protein 65kda, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, IL31RA - interleukin 31 receptor a, ADCY2 - adenylate cyclase 2 (brain), DUSP4 - dual specificity phosphatase 4, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, ATP6V0E2 - atpase, h+ transporting v0 subunit e2, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, SPRY2 - sprouty homolog 2 (drosophila), EPHB1 - eph receptor b1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), EPHA4 - eph receptor a4, SULF2 - sulfatase 2, TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, AKAP13 - a kinase (prka) anchor protein 13, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, FYN - fyn oncogene related to src, fgr, yes, ZFAND5 - zinc finger, an1-type domain 5, NR4A1 - nuclear receptor subfamily 4, group a, member 1, SH3GL2 - sh3-domain grb2-like 2]" GO:0051247 positive regulation of protein metabolic process 3.96E-04 2.62E-02 1.61 16376 982 548 53 "[HES5 - hairy and enhancer of split 5 (drosophila), PAIP1 - poly(a) binding protein interacting protein 1, CAPN3 - calpain 3, (p94), MAP3K8 - mitogen-activated protein kinase kinase kinase 8, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, PIAS1 - protein inhibitor of activated stat, 1, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPER1 - g protein-coupled estrogen receptor 1, F2R - coagulation factor ii (thrombin) receptor, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, KLF2 - kruppel-like factor 2 (lung), AHRR - aryl-hydrocarbon receptor repressor, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), CREBRF - creb3 regulatory factor, TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, PELI1 - pellino e3 ubiquitin protein ligase 1, ZEB2 - zinc finger e-box binding homeobox 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), TIPARP - tcdd-inducible poly(adp-ribose) polymerase, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4]" GO:0007050 cell cycle arrest 4.19E-04 2.76E-02 2.99 16376 130 548 13 "[TGFBR1 - transforming growth factor, beta receptor 1, HBP1 - hmg-box transcription factor 1, CAB39L - calcium binding protein 39-like, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), TP53INP1 - tumor protein p53 inducible nuclear protein 1, JMY - junction mediating and regulatory protein, p53 cofactor, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, DUSP1 - dual specificity phosphatase 1, MAP2K6 - mitogen-activated protein kinase kinase 6, KAT2B - k(lysine) acetyltransferase 2b, APC - adenomatous polyposis coli, GAS1 - growth arrest-specific 1]" GO:0065009 regulation of molecular function 4.39E-04 2.86E-02 1.36 16376 2323 548 106 "[A2M - alpha-2-macroglobulin, BNIP2 - bcl2/adenovirus e1b 19kda interacting protein 2, FN1 - fibronectin 1, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, PBX1 - pre-b-cell leukemia homeobox 1, APC - adenomatous polyposis coli, CD109 - cd109 molecule, ERRFI1 - erbb receptor feedback inhibitor 1, GADD45G - growth arrest and dna-damage-inducible, gamma, EPS8L1 - eps8-like 1, PIFO - primary cilia formation, SERPINB1 - serpin peptidase inhibitor, clade b (ovalbumin), member 1, CYTL1 - cytokine-like 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, DOCK10 - dedicator of cytokinesis 10, TRIM22 - tripartite motif containing 22, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, PTCH1 - patched 1, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, FZD6 - frizzled family receptor 6, GPSM2 - g-protein signaling modulator 2, ADCY8 - adenylate cyclase 8 (brain), SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, AKAP7 - a kinase (prka) anchor protein 7, SERINC1 - serine incorporator 1, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, DAPK1 - death-associated protein kinase 1, S100A10 - s100 calcium binding protein a10, BCL10 - b-cell cll/lymphoma 10, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, TBC1D8 - tbc1 domain family, member 8 (with gram domain), ARHGAP9 - rho gtpase activating protein 9, MGST2 - microsomal glutathione s-transferase 2, IFIT2 - interferon-induced protein with tetratricopeptide repeats 2, IFIT1 - interferon-induced protein with tetratricopeptide repeats 1, TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), TIMP4 - timp metallopeptidase inhibitor 4, PTX3 - pentraxin 3, long, ARID5B - at rich interactive domain 5b (mrf1-like), SERINC5 - serine incorporator 5, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, PILRB - paired immunoglobin-like type 2 receptor beta, DOCK6 - dedicator of cytokinesis 6, HDAC5 - histone deacetylase 5, ATF3 - activating transcription factor 3, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, DUSP4 - dual specificity phosphatase 4, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, DUSP1 - dual specificity phosphatase 1, CCNL1 - cyclin l1, F2R - coagulation factor ii (thrombin) receptor, FZD2 - frizzled family receptor 2, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, PROX1 - prospero homeobox 1, TRIM62 - tripartite motif containing 62, LRP6 - low density lipoprotein receptor-related protein 6, CCNG1 - cyclin g1, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), TWIST1 - twist basic helix-loop-helix transcription factor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, TPP1 - tripeptidyl peptidase i, MAPK10 - mitogen-activated protein kinase 10, TGFBR1 - transforming growth factor, beta receptor 1, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, PELI1 - pellino e3 ubiquitin protein ligase 1, EPHA4 - eph receptor a4, SSBP1 - single-stranded dna binding protein 1, mitochondrial, BAMBI - bmp and activin membrane-bound inhibitor, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, SPATA13 - spermatogenesis associated 13, CYR61 - cysteine-rich, angiogenic inducer, 61, CRBN - cereblon, ANXA1 - annexin a1, SGK1 - serum/glucocorticoid regulated kinase 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, NR4A1 - nuclear receptor subfamily 4, group a, member 1, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0038095 Fc-epsilon receptor signaling pathway 4.38E-04 2.87E-02 2.72 16376 165 548 15 "[MAPK10 - mitogen-activated protein kinase 10, FGFR3 - fibroblast growth factor receptor 3, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, BCL10 - b-cell cll/lymphoma 10, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, GAB2 - grb2-associated binding protein 2, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FYN - fyn oncogene related to src, fgr, yes, NR4A1 - nuclear receptor subfamily 4, group a, member 1, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase]" GO:0032268 regulation of cellular protein metabolic process 4.43E-04 2.87E-02 1.48 16376 1451 548 72 "[HES5 - hairy and enhancer of split 5 (drosophila), TIMP2 - timp metallopeptidase inhibitor 2, CAPN3 - calpain 3, (p94), PAIP1 - poly(a) binding protein interacting protein 1, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, CTGF - connective tissue growth factor, TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), DKK1 - dickkopf wnt signaling pathway inhibitor 1, PILRB - paired immunoglobin-like type 2 receptor beta, ATF3 - activating transcription factor 3, APC - adenomatous polyposis coli, ERRFI1 - erbb receptor feedback inhibitor 1, PIAS1 - protein inhibitor of activated stat, 1, DUSP4 - dual specificity phosphatase 4, TSPYL5 - tspy-like 5, GADD45G - growth arrest and dna-damage-inducible, gamma, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, GPER1 - g protein-coupled estrogen receptor 1, AKAP13 - a kinase (prka) anchor protein 13, CCNL1 - cyclin l1, DUSP1 - dual specificity phosphatase 1, F2R - coagulation factor ii (thrombin) receptor, KDM3A - lysine (k)-specific demethylase 3a, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3, KLF15 - kruppel-like factor 15, CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, LRP6 - low density lipoprotein receptor-related protein 6, CCNG1 - cyclin g1, EGR1 - early growth response 1, AHRR - aryl-hydrocarbon receptor repressor, TWIST1 - twist basic helix-loop-helix transcription factor 1, PDGFD - platelet derived growth factor d, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, MAPK10 - mitogen-activated protein kinase 10, INSM1 - insulinoma-associated 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ZEB2 - zinc finger e-box binding homeobox 2, PELI1 - pellino e3 ubiquitin protein ligase 1, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, PPP1R15A - protein phosphatase 1, regulatory subunit 15a, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut), PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0031960 response to corticosteroid 4.51E-04 2.91E-02 2.97 16376 131 548 13 "[ACSBG1 - acyl-coa synthetase bubblegum family member 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, CTGF - connective tissue growth factor, FOSB - fbj murine osteosarcoma viral oncogene homolog b, ALDH3A1 - aldehyde dehydrogenase 3 family, member a1, FOS - fbj murine osteosarcoma viral oncogene homolog, ADM - adrenomedullin, GPER1 - g protein-coupled estrogen receptor 1, ANXA1 - annexin a1, DUSP1 - dual specificity phosphatase 1, BCHE - butyrylcholinesterase, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, BCKDHB - branched chain keto acid dehydrogenase e1, beta polypeptide]" GO:0007224 smoothened signaling pathway 4.55E-04 2.92E-02 4.35 16376 55 548 8 "[BOC - boc cell adhesion associated, oncogene regulated, HES5 - hairy and enhancer of split 5 (drosophila), TTC21B - tetratricopeptide repeat domain 21b, TTBK2 - tau tubulin kinase 2, NKX6-1 - nk6 homeobox 1, PAX6 - paired box 6, PTCH1 - patched 1, HHAT - hedgehog acyltransferase]" GO:0048666 neuron development 4.70E-04 3.00E-02 3.12 16376 115 548 12 "[RUNX3 - runt-related transcription factor 3, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), CRB1 - crumbs homolog 1 (drosophila), RORB - rar-related orphan receptor b, MAP2 - microtubule-associated protein 2, INSM1 - insulinoma-associated 1, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, PAX6 - paired box 6, ETV1 - ets variant 1, EN1 - engrailed homeobox 1, ZBTB18 - zinc finger and btb domain containing 18, FZD2 - frizzled family receptor 2]" GO:2000736 regulation of stem cell differentiation 4.85E-04 3.08E-02 3.56 16376 84 548 10 "[HES5 - hairy and enhancer of split 5 (drosophila), TWIST1 - twist basic helix-loop-helix transcription factor 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), JAG1 - jagged 1, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SOX6 - sry (sex determining region y)-box 6, BAMBI - bmp and activin membrane-bound inhibitor, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, BMP7 - bone morphogenetic protein 7]" GO:0035914 skeletal muscle cell differentiation 5.12E-04 3.23E-02 4.86 16376 43 548 7 "[EGR1 - early growth response 1, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, FOS - fbj murine osteosarcoma viral oncogene homolog, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ATF3 - activating transcription factor 3, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, KLF5 - kruppel-like factor 5 (intestinal)]" GO:0035113 embryonic appendage morphogenesis 5.33E-04 3.33E-02 3.52 16376 85 548 10 "[TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, DKK1 - dickkopf wnt signaling pathway inhibitor 1, OSR2 - odd-skipped related 2 (drosophila), EN1 - engrailed homeobox 1, FBN2 - fibrillin 2, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, SP8 - sp8 transcription factor, BMP7 - bone morphogenetic protein 7]" GO:0030326 embryonic limb morphogenesis 5.33E-04 3.35E-02 3.52 16376 85 548 10 "[TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, DKK1 - dickkopf wnt signaling pathway inhibitor 1, OSR2 - odd-skipped related 2 (drosophila), EN1 - engrailed homeobox 1, FBN2 - fibrillin 2, PTCH1 - patched 1, LRP6 - low density lipoprotein receptor-related protein 6, SP8 - sp8 transcription factor, BMP7 - bone morphogenetic protein 7]" GO:0002009 morphogenesis of an epithelium 5.50E-04 3.40E-02 2.23 16376 282 548 21 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HES5 - hairy and enhancer of split 5 (drosophila), CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, SPRY2 - sprouty homolog 2 (drosophila), NRARP - notch-regulated ankyrin repeat protein, PTCH1 - patched 1, FREM2 - fras1 related extracellular matrix protein 2, LRP6 - low density lipoprotein receptor-related protein 6, DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, NOTCH4 - notch 4, EYA1 - eyes absent homolog 1 (drosophila), PBX1 - pre-b-cell leukemia homeobox 1, NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, JAG1 - jagged 1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), ADM - adrenomedullin, BMP7 - bone morphogenetic protein 7, PCDH8 - protocadherin 8]" GO:0030856 regulation of epithelial cell differentiation 5.57E-04 3.41E-02 3.25 16376 101 548 11 "[ERRFI1 - erbb receptor feedback inhibitor 1, NOTCH4 - notch 4, NKX6-1 - nk6 homeobox 1, APOLD1 - apolipoprotein l domain containing 1, PAX6 - paired box 6, ZEB2 - zinc finger e-box binding homeobox 2, BTG1 - b-cell translocation gene 1, anti-proliferative, MAFF - v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog f, APC - adenomatous polyposis coli, RFX3 - regulatory factor x, 3 (influences hla class ii expression), DLL1 - delta-like 1 (drosophila)]" GO:2001236 regulation of extrinsic apoptotic signaling pathway 5.53E-04 3.41E-02 2.77 16376 151 548 14 "[RUNX3 - runt-related transcription factor 3, TGFBR1 - transforming growth factor, beta receptor 1, SCG2 - secretogranin ii, ITM2C - integral membrane protein 2c, DAPK1 - death-associated protein kinase 1, BCL10 - b-cell cll/lymphoma 10, EYA1 - eyes absent homolog 1 (drosophila), TRPS1 - trichorhinophalangeal syndrome i, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), GPER1 - g protein-coupled estrogen receptor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, FYN - fyn oncogene related to src, fgr, yes, TNFSF10 - tumor necrosis factor (ligand) superfamily, member 10, GAS1 - growth arrest-specific 1]" GO:0023014 signal transduction by phosphorylation 5.48E-04 3.41E-02 2.48 16376 205 548 17 "[TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, SCG2 - secretogranin ii, DUSP4 - dual specificity phosphatase 4, FGF14 - fibroblast growth factor 14, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, ACVR2A - activin a receptor, type iia, FOS - fbj murine osteosarcoma viral oncogene homolog, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, PAK6 - p21 protein (cdc42/rac)-activated kinase 6, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, DUSP10 - dual specificity phosphatase 10]" GO:0001934 positive regulation of protein phosphorylation 5.62E-04 3.43E-02 1.77 16376 624 548 37 "[HES5 - hairy and enhancer of split 5 (drosophila), PROX1 - prospero homeobox 1, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, ACVR2A - activin a receptor, type iia, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, CTGF - connective tissue growth factor, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, PILRB - paired immunoglobin-like type 2 receptor beta, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), ATF3 - activating transcription factor 3, IL31RA - interleukin 31 receptor a, TPP1 - tripeptidyl peptidase i, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, ADCY2 - adenylate cyclase 2 (brain), TGFBR1 - transforming growth factor, beta receptor 1, MAPK10 - mitogen-activated protein kinase 10, CTDSP2 - ctd (carboxy-terminal domain, rna polymerase ii, polypeptide a) small phosphatase 2, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), ZEB2 - zinc finger e-box binding homeobox 2, AFAP1L2 - actin filament associated protein 1-like 2, PELI2 - pellino e3 ubiquitin protein ligase family member 2, EPHA4 - eph receptor a4, CLIP3 - cap-gly domain containing linker protein 3, GNAI2 - guanine nucleotide binding protein (g protein), alpha inhibiting activity polypeptide 2, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, THBS4 - thrombospondin 4, GPER1 - g protein-coupled estrogen receptor 1, CSPG4 - chondroitin sulfate proteoglycan 4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, F2R - coagulation factor ii (thrombin) receptor, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0048641 regulation of skeletal muscle tissue development 5.82E-04 3.53E-02 4.19 16376 57 548 8 "[BOC - boc cell adhesion associated, oncogene regulated, TWIST1 - twist basic helix-loop-helix transcription factor 1, CAPN3 - calpain 3, (p94), DKK1 - dickkopf wnt signaling pathway inhibitor 1, TSC22D3 - tsc22 domain family, member 3, BTG1 - b-cell translocation gene 1, anti-proliferative, NR1D2 - nuclear receptor subfamily 1, group d, member 2, HDAC5 - histone deacetylase 5]" GO:0045995 regulation of embryonic development 6.42E-04 3.86E-02 3.43 16376 87 548 10 "[FZD7 - frizzled family receptor 7, DKK1 - dickkopf wnt signaling pathway inhibitor 1, MAP2K5 - mitogen-activated protein kinase kinase 5, OSR2 - odd-skipped related 2 (drosophila), NRARP - notch-regulated ankyrin repeat protein, TGIF1 - tgfb-induced factor homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, FZD2 - frizzled family receptor 2, BMP7 - bone morphogenetic protein 7, KLF4 - kruppel-like factor 4 (gut)]" GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 6.41E-04 3.87E-02 3.01 16376 119 548 12 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ID3 - inhibitor of dna binding 3, dominant negative helix-loop-helix protein, TWIST1 - twist basic helix-loop-helix transcription factor 1, PBX1 - pre-b-cell leukemia homeobox 1, PROX1 - prospero homeobox 1, FZD6 - frizzled family receptor 6, MAP2K5 - mitogen-activated protein kinase kinase 5, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, PELI1 - pellino e3 ubiquitin protein ligase 1, PTCH1 - patched 1, BMP7 - bone morphogenetic protein 7, KLF4 - kruppel-like factor 4 (gut)]" GO:2000778 positive regulation of interleukin-6 secretion 6.91E-04 4.11E-02 14.94 16376 6 548 3 "[TWIST1 - twist basic helix-loop-helix transcription factor 1, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1]" GO:0001667 ameboidal cell migration 6.91E-04 4.13E-02 2.99 16376 120 548 12 "[TGFBR1 - transforming growth factor, beta receptor 1, CORO1B - coronin, actin binding protein, 1b, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, TWIST1 - twist basic helix-loop-helix transcription factor 1, SCG2 - secretogranin ii, CXCR4 - chemokine (c-x-c motif) receptor 4, EGR3 - early growth response 3, ZEB2 - zinc finger e-box binding homeobox 2, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ZFAND5 - zinc finger, an1-type domain 5, LRP6 - low density lipoprotein receptor-related protein 6, ARID5B - at rich interactive domain 5b (mrf1-like)]" GO:0060325 face morphogenesis 7.00E-04 4.15E-02 5.43 16376 33 548 6 "[TIPARP - tcdd-inducible poly(adp-ribose) polymerase, DKK1 - dickkopf wnt signaling pathway inhibitor 1, CRISPLD2 - cysteine-rich secretory protein lccl domain containing 2, LRP6 - low density lipoprotein receptor-related protein 6, ARID5B - at rich interactive domain 5b (mrf1-like), PDGFRA - platelet-derived growth factor receptor, alpha polypeptide]" GO:0000902 cell morphogenesis 7.21E-04 4.25E-02 2.59 16376 173 548 15 "[TGFBR1 - transforming growth factor, beta receptor 1, MAP7 - microtubule-associated protein 7, FN1 - fibronectin 1, PROX1 - prospero homeobox 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, S100A4 - s100 calcium binding protein a4, SOX6 - sry (sex determining region y)-box 6, LRP6 - low density lipoprotein receptor-related protein 6, KLF2 - kruppel-like factor 2 (lung), NOTCH4 - notch 4, HAS2 - hyaluronan synthase 2, FZD7 - frizzled family receptor 7, DKK1 - dickkopf wnt signaling pathway inhibitor 1, BMP7 - bone morphogenetic protein 7, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase]" GO:0045664 regulation of neuron differentiation 7.24E-04 4.25E-02 2.02 16376 370 548 25 "[HES5 - hairy and enhancer of split 5 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, TIMP2 - timp metallopeptidase inhibitor 2, ITM2C - integral membrane protein 2c, PROX1 - prospero homeobox 1, RUFY3 - run and fyve domain containing 3, PAX6 - paired box 6, DLL1 - delta-like 1 (drosophila), SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, PBX1 - pre-b-cell leukemia homeobox 1, JAG1 - jagged 1, NR2F1 - nuclear receptor subfamily 2, group f, member 1, ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), SLIT1 - slit homolog 1 (drosophila), DNMT3B - dna (cytosine-5-)-methyltransferase 3 beta, TGIF1 - tgfb-induced factor homeobox 1, EPHA4 - eph receptor a4, EYA1 - eyes absent homolog 1 (drosophila), NKX6-1 - nk6 homeobox 1, FKBP1B - fk506 binding protein 1b, 12.6 kda, PTPRD - protein tyrosine phosphatase, receptor type, d, FYN - fyn oncogene related to src, fgr, yes, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0001525 angiogenesis 7.56E-04 4.37E-02 2.34 16376 230 548 18 "[TGFBR1 - transforming growth factor, beta receptor 1, SCG2 - secretogranin ii, FN1 - fibronectin 1, HEY1 - hairy/enhancer-of-split related with yrpw motif 1, HS6ST1 - heparan sulfate 6-o-sulfotransferase 1, EPHB1 - eph receptor b1, CTGF - connective tissue growth factor, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, CYR61 - cysteine-rich, angiogenic inducer, 61, ACKR3 - atypical chemokine receptor 3, SAT1 - spermidine/spermine n1-acetyltransferase 1, JAG1 - jagged 1, APOLD1 - apolipoprotein l domain containing 1, FZD6 - frizzled family receptor 6, PLCD1 - phospholipase c, delta 1, VEZF1 - vascular endothelial zinc finger 1, CSPG4 - chondroitin sulfate proteoglycan 4, KLF5 - kruppel-like factor 5 (intestinal)]" GO:0042326 negative regulation of phosphorylation 7.55E-04 4.39E-02 2.17 16376 289 548 21 "[ERRFI1 - erbb receptor feedback inhibitor 1, DUSP4 - dual specificity phosphatase 4, INSM1 - insulinoma-associated 1, GADD45G - growth arrest and dna-damage-inducible, gamma, CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), ATXN1 - ataxin 1, SPRY2 - sprouty homolog 2 (drosophila), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), LRP6 - low density lipoprotein receptor-related protein 6, MICAL1 - microtubule associated monooxygenase, calponin and lim domain containing 1, KLF4 - kruppel-like factor 4 (gut), TWIST1 - twist basic helix-loop-helix transcription factor 1, DKK1 - dickkopf wnt signaling pathway inhibitor 1, DUSP1 - dual specificity phosphatase 1, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, APC - adenomatous polyposis coli, BMP7 - bone morphogenetic protein 7, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta]" GO:0071900 regulation of protein serine/threonine kinase activity 7.51E-04 4.39E-02 1.98 16376 392 548 26 "[CXCR4 - chemokine (c-x-c motif) receptor 4, PROX1 - prospero homeobox 1, LRP6 - low density lipoprotein receptor-related protein 6, CCNG1 - cyclin g1, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, APC - adenomatous polyposis coli, MAP3K1 - mitogen-activated protein kinase kinase kinase 1, e3 ubiquitin protein ligase, MAPK10 - mitogen-activated protein kinase 10, DUSP4 - dual specificity phosphatase 4, GADD45G - growth arrest and dna-damage-inducible, gamma, SPRY2 - sprouty homolog 2 (drosophila), CDKN1C - cyclin-dependent kinase inhibitor 1c (p57, kip2), CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), ZEB2 - zinc finger e-box binding homeobox 2, EPHA4 - eph receptor a4, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, DUSP1 - dual specificity phosphatase 1, CCNL1 - cyclin l1, KAT2B - k(lysine) acetyltransferase 2b, DUSP10 - dual specificity phosphatase 10, PKIB - protein kinase (camp-dependent, catalytic) inhibitor beta, BMP7 - bone morphogenetic protein 7, MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3]" GO:0010720 positive regulation of cell development 7.91E-04 4.56E-02 2.48 16376 193 548 16 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), CXCR4 - chemokine (c-x-c motif) receptor 4, TGFB1I1 - transforming growth factor beta 1 induced transcript 1, PAX6 - paired box 6, RFX3 - regulatory factor x, 3 (influences hla class ii expression), EPHA4 - eph receptor a4, BAMBI - bmp and activin membrane-bound inhibitor, S100A10 - s100 calcium binding protein a10, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, TWIST1 - twist basic helix-loop-helix transcription factor 1, GCNT2 - glucosaminyl (n-acetyl) transferase 2, i-branching enzyme (i blood group), NKX6-1 - nk6 homeobox 1, GPER1 - g protein-coupled estrogen receptor 1, PTPRD - protein tyrosine phosphatase, receptor type, d, SERPINF1 - serpin peptidase inhibitor, clade f (alpha-2 antiplasmin, pigment epithelium derived factor), member 1]" GO:0060349 bone morphogenesis 8.40E-04 4.73E-02 6.5 16376 23 548 5 "[CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, HAS2 - hyaluronan synthase 2, FGFR3 - fibroblast growth factor receptor 3, OSR2 - odd-skipped related 2 (drosophila), LRP6 - low density lipoprotein receptor-related protein 6]" GO:0009953 dorsal/ventral pattern formation 8.26E-04 4.74E-02 3.98 16376 60 548 8 "[INTU - inturned planar cell polarity protein, PAX6 - paired box 6, EN1 - engrailed homeobox 1, PTCH1 - patched 1, TGIF1 - tgfb-induced factor homeobox 1, GAS1 - growth arrest-specific 1, SP8 - sp8 transcription factor, APC - adenomatous polyposis coli]" GO:0042474 middle ear morphogenesis 8.40E-04 4.75E-02 6.5 16376 23 548 5 "[EYA1 - eyes absent homolog 1 (drosophila), EYA4 - eyes absent homolog 4 (drosophila), INSIG2 - insulin induced gene 2, OSR2 - odd-skipped related 2 (drosophila), GAS1 - growth arrest-specific 1]" GO:0045747 positive regulation of Notch signaling pathway 8.40E-04 4.77E-02 6.5 16376 23 548 5 "[HES5 - hairy and enhancer of split 5 (drosophila), EYA1 - eyes absent homolog 1 (drosophila), JAG1 - jagged 1, TSPAN14 - tetraspanin 14, DLL1 - delta-like 1 (drosophila)]" GO:0002521 leukocyte differentiation 8.36E-04 4.77E-02 2.32 16376 232 548 18 "[ID2 - inhibitor of dna binding 2, dominant negative helix-loop-helix protein, CITED2 - cbp/p300-interacting transactivator, with glu/asp-rich carboxy-terminal domain, 2, LGALS8 - lectin, galactoside-binding, soluble, 8, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), EGR1 - early growth response 1, PDE2A - phosphodiesterase 2a, cgmp-stimulated, GAB2 - grb2-associated binding protein 2, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FZD7 - frizzled family receptor 7, SATB1 - satb homeobox 1, KLF6 - kruppel-like factor 6, DHRS2 - dehydrogenase/reductase (sdr family) member 2, ADA - adenosine deaminase, ANXA1 - annexin a1, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, HDAC5 - histone deacetylase 5, IL31RA - interleukin 31 receptor a, APC - adenomatous polyposis coli]" GO:0030111 regulation of Wnt signaling pathway 8.84E-04 4.95E-02 2.45 16376 195 548 16 "[APCDD1 - adenomatosis polyposis coli down-regulated 1, FGFR3 - fibroblast growth factor receptor 3, NRARP - notch-regulated ankyrin repeat protein, ZEB2 - zinc finger e-box binding homeobox 2, LRP6 - low density lipoprotein receptor-related protein 6, CXXC4 - cxxc finger protein 4, TLE1 - transducin-like enhancer of split 1 (e(sp1) homolog, drosophila), BAMBI - bmp and activin membrane-bound inhibitor, EGR1 - early growth response 1, SULF2 - sulfatase 2, ANKRD6 - ankyrin repeat domain 6, FZD6 - frizzled family receptor 6, DKK1 - dickkopf wnt signaling pathway inhibitor 1, DACT3 - dishevelled-binding antagonist of beta-catenin 3, APC - adenomatous polyposis coli, TCF7L1 - transcription factor 7-like 1 (t-cell specific, hmg-box)]" GO:0032677 regulation of interleukin-8 production 8.90E-04 4.96E-02 4.45 16376 47 548 7 "[ANXA1 - annexin a1, MAP2K5 - mitogen-activated protein kinase kinase 5, F2R - coagulation factor ii (thrombin) receptor, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, AFAP1L2 - actin filament associated protein 1-like 2, BCL10 - b-cell cll/lymphoma 10, KLF4 - kruppel-like factor 4 (gut)]" GO:0001938 positive regulation of endothelial cell proliferation 9.24E-04 5.10E-02 3.92 16376 61 548 8 "[SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, THBS4 - thrombospondin 4, SCG2 - secretogranin ii, PROX1 - prospero homeobox 1, FGFR3 - fibroblast growth factor receptor 3, EGR3 - early growth response 3, NRARP - notch-regulated ankyrin repeat protein, NR4A1 - nuclear receptor subfamily 4, group a, member 1]" GO:0035556 intracellular signal transduction 9.22E-04 5.12E-02 1.46 16376 1389 548 68 "[A2M - alpha-2-macroglobulin, CAPS - calcyphosine, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, GSN - gelsolin, RAB8B - rab8b, member ras oncogene family, SDCBP - syndecan binding protein (syntenin), CTGF - connective tissue growth factor, DCX - doublecortin, GAB2 - grb2-associated binding protein 2, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), CHN2 - chimerin 2, DOCK6 - dedicator of cytokinesis 6, PHLPP1 - ph domain and leucine rich repeat protein phosphatase 1, WSB1 - wd repeat and socs box containing 1, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, KSR1 - kinase suppressor of ras 1, PIAS1 - protein inhibitor of activated stat, 1, DUSP4 - dual specificity phosphatase 4, RAB3D - rab3d, member ras oncogene family, SPSB3 - spla/ryanodine receptor domain and socs box containing 3, NCALD - neurocalcin delta, NFKBIA - nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha, EPS8L1 - eps8-like 1, PLCG2 - phospholipase c, gamma 2 (phosphatidylinositol-specific), FKBP1B - fk506 binding protein 1b, 12.6 kda, AKAP13 - a kinase (prka) anchor protein 13, PLCD1 - phospholipase c, delta 1, DUSP1 - dual specificity phosphatase 1, IFIH1 - interferon induced with helicase c domain 1, FYN - fyn oncogene related to src, fgr, yes, DOCK10 - dedicator of cytokinesis 10, DUSP10 - dual specificity phosphatase 10, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, CXCR4 - chemokine (c-x-c motif) receptor 4, FGFR3 - fibroblast growth factor receptor 3, STK38L - serine/threonine kinase 38 like, JMY - junction mediating and regulatory protein, p53 cofactor, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide, PIK3R1 - phosphoinositide-3-kinase, regulatory subunit 1 (alpha), NFATC4 - nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4, RASD1 - ras, dexamethasone-induced 1, MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, ADCY8 - adenylate cyclase 8 (brain), IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b, RND3 - rho family gtpase 3, AMOTL2 - angiomotin like 2, ADCY2 - adenylate cyclase 2 (brain), MAPK10 - mitogen-activated protein kinase 10, AKAP7 - a kinase (prka) anchor protein 7, CBLB - cbl proto-oncogene b, e3 ubiquitin protein ligase, FGD3 - fyve, rhogef and ph domain containing 3, ARHGEF4 - rho guanine nucleotide exchange factor (gef) 4, CDKN1B - cyclin-dependent kinase inhibitor 1b (p27, kip1), FAT4 - fat atypical cadherin 4, DAPK1 - death-associated protein kinase 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FOS - fbj murine osteosarcoma viral oncogene homolog, PDE2A - phosphodiesterase 2a, cgmp-stimulated, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, PIK3C2B - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta, ADM - adrenomedullin, PRKAR2B - protein kinase, camp-dependent, regulatory, type ii, beta, CSPG4 - chondroitin sulfate proteoglycan 4, NR4A1 - nuclear receptor subfamily 4, group a, member 1, ARHGAP9 - rho gtpase activating protein 9]" GO:0060037 pharyngeal system development 9.50E-04 5.18E-02 8.54 16376 14 548 4 "[TGFBR1 - transforming growth factor, beta receptor 1, EYA1 - eyes absent homolog 1 (drosophila), PTCH1 - patched 1, PLXNA2 - plexin a2]" GO:0033233 regulation of protein sumoylation 9.50E-04 5.20E-02 8.54 16376 14 548 4 "[AHRR - aryl-hydrocarbon receptor repressor, EGR1 - early growth response 1, PIAS1 - protein inhibitor of activated stat, 1, CAPN3 - calpain 3, (p94)]" GO:0008347 glial cell migration 9.50E-04 5.23E-02 8.54 16376 14 548 4 "[APCDD1 - adenomatosis polyposis coli down-regulated 1, CSPG4 - chondroitin sulfate proteoglycan 4, VCAN - versican, EPHA4 - eph receptor a4]" GO:0001944 vasculature development 9.70E-04 5.24E-02 5.12 16376 35 548 6 "[ERRFI1 - erbb receptor feedback inhibitor 1, PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, FZD7 - frizzled family receptor 7, ZFAND5 - zinc finger, an1-type domain 5, FZD2 - frizzled family receptor 2, PDGFRA - platelet-derived growth factor receptor, alpha polypeptide]" GO:0031346 positive regulation of cell projection organization 9.66E-04 5.25E-02 2.52 16376 178 548 15 "[TGFBR1 - transforming growth factor, beta receptor 1, CDC42EP4 - cdc42 effector protein (rho gtpase binding) 4, ROBO2 - roundabout, axon guidance receptor, homolog 2 (drosophila), CBFA2T2 - core-binding factor, runt domain, alpha subunit 2; translocated to, 2, RAB8B - rab8b, member ras oncogene family, EPHA4 - eph receptor a4, EPS8L1 - eps8-like 1, CORO1B - coronin, actin binding protein, 1b, SEMA5A - sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (tm) and short cytoplasmic domain, (semaphorin) 5a, FKBP1B - fk506 binding protein 1b, 12.6 kda, PTPRD - protein tyrosine phosphatase, receptor type, d, FYN - fyn oncogene related to src, fgr, yes, F2RL1 - coagulation factor ii (thrombin) receptor-like 1, APC - adenomatous polyposis coli, BMP7 - bone morphogenetic protein 7]" GO:0000165 MAPK cascade 9.81E-04 5.28E-02 2.61 16376 160 548 14 "[MAPK10 - mitogen-activated protein kinase 10, SCG2 - secretogranin ii, FGF14 - fibroblast growth factor 14, DUSP4 - dual specificity phosphatase 4, FGFR3 - fibroblast growth factor receptor 3, MAP3K8 - mitogen-activated protein kinase kinase kinase 8, FOS - fbj murine osteosarcoma viral oncogene homolog, TNFRSF19 - tumor necrosis factor receptor superfamily, member 19, AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8), MAP2K5 - mitogen-activated protein kinase kinase 5, MAP2K6 - mitogen-activated protein kinase kinase 6, DUSP10 - dual specificity phosphatase 10, IL31RA - interleukin 31 receptor a, ITPKB - inositol-trisphosphate 3-kinase b]"