New Positive Ca²⁺-Activated K⁺ Channel Gating Modulators with Selectivity for K_Ca3.1

Data Supplement

Files in this Data Supplement:

• Supplemental Figures -

  Supplemental Figure 1 - Differences in the hydrogen bonding pattern in the crystal structures of SKA-120 and SKA-121

  Supplemental Figure 2 - Representative sweep plots of QPatch NaV1.2 recordings from N1E-115 neuroblastoma and NaV1.5 recordings from HEK-293 cells

  Supplemental Figure 3 - Telemetric blood pressure measurements after i.p. injection of 30 mg/kg SKA-111, SKA-121, or vehicle (Ve)