PROGRAM !Codes for the estimation of physiological parameters for children (M, male; F, female). INITIAL CONSTANT age = 10 !(year) !Estimation of QC (L/h) CONSTANT y0_QC_M = 79.7195 CONSTANT a_QC_M = 19.2943 CONSTANT b_QC_M = -0.5954 CONSTANT c_QC_M = 0.0501 CONSTANT y0_QC_F = 78.5177 CONSTANT a_QC_F = 6.9146 CONSTANT b_QC_F = 2.6301 CONSTANT c_QC_F = -0.1122 !Estimation of brain blood flow (L/h) CONSTANT y0_QBrain_M = 25.2643 CONSTANT a_QBrain_M = 14.5166 CONSTANT b_QBrain_M = -1.6861 CONSTANT c_QBrain_M = 0.0537 CONSTANT y0_QBrain_F = 24.0103 CONSTANT a_QBrain_F = 12.9428 CONSTANT b_QBrain_F = -1.4845 CONSTANT c_QBrain_F = 0.0462 CONSTANT QFatC = 0.053 !(%QC) |Fractional blood flow to the fats Constant QgonadC = 0.00054 !(%QC) |Fractional blood flow to the goands CONSTANT QHeartC = 0.038 !(%QC) |Fractional blood flow to the heart TABLE QliverC, 1,12/4,5, 6,7,8,9,10,11,12,13,14,15,19.5,19.5,19.5,19.5,19.5,39.9,39.9& ,39.9,39.9,54.9,54.9,54.9/ !(%QC) |Fractional blood flow to the liver !Estimation of plasma volume CONSTANT a_VPlasma_M = 0.8139 CONSTANT b_VPlasma_M = 1.9224 CONSTANT a_Vplasma_F = 0.7988 CONSTANT b_VPlasma_F = 1.9314 TABLE VfatC, 1,3/6, 10, 14,3.68, 6.25, 11.49/ !estimation of fractional Volume of the fat !Estimation of liver volume CONSTANT y0_Liver_M = 157.52 CONSTANT a_Liver_M = 262.02 CONSTANT b_Liver_M = -65.624 CONSTANT c_Liver_M = 7.9052 CONSTANT d_Liver_M = -0.3975 CONSTANT e_Liver_M = 0.0072 CONSTANT y0_Liver_F = 139.65 CONSTANT a_Liver_F = 251.9 CONSTANT b_Liver_F = -59.539 CONSTANT c_Liver_F = 7.0134 CONSTANT d_Liver_F = -0.3396 CONSTANT e_Liver_F = 0.0057 !Estimation of heart volume CONSTANT y0_Heart_M = 20.364 CONSTANT a_Heart_M = 32.213 CONSTANT b_Heart_M = -5.7113 CONSTANT c_Heart_M = 0.5051 CONSTANT d_Heart_M = -0.0132 CONSTANT e_Heart_M = 0 CONSTANT y0_Heart_F = 21.509 CONSTANT a_Heart_F = 28.486 CONSTANT b_Heart_F = -5.5116 CONSTANT c_Heart_F = 0.6539 CONSTANT d_Heart_F = -2.97679E-2 CONSTANT e_Heart_F = 4.246E-4 !Estimation of brain volume CONSTANT a_Brain_M = 10000 CONSTANT b_Brain_M = 0.213 CONSTANT c_Brain_M = 6.030 CONSTANT d_Brain_M = 6.895 CONSTANT a_Brain_F = 10000 CONSTANT b_Brain_F = 0.226 CONSTANT c_Brain_F = 6.521 CONSTANT d_Brain_F = 7.514 !Estimation of gonads volume CONSTANT y0_Gonads_M = 1.78 CONSTANT a_Gonads_M = 1.0584 CONSTANT b_Gonads_M = -0.104 CONSTANT c_Gonads_M = -0.01 CONSTANT d_Gonads_M = 0.0013 CONSTANT y0_Gonads_F = 2.1725 CONSTANT a_Gonads_F = 0.2333 CONSTANT b_Gonads_F = 0.0412 CONSTANT c_Gonads_F = 0.0044 CONSTANT d_Gonads_F = 0 CONSTANT sex = 1 ! 1 for Male and 2 for Female CONSTANT BW = 54.9 ! (kg) END DYNAMIC ALGORITHM IALG = 2 NSTEPS NSTP = 1 MAXTERVAL MAXT = 1.0e9 MINTERVAL MINT = 1.0e-9 DERIVATIVE If (sex .Eq. 1) Then QC = y0_QC_M+a_QC_M*age+b_QC_M*(age^2)+c_QC_M*(age^3) Qbrain = y0_QBrain_M+a_QBrain_M*age+b_QBrain_M*(age^2)+c_QBrain_M*(age^3) Vliver1 = y0_Liver_M +a_Liver_M*age+b_Liver_M*(age^2)+c_Liver_M*(age^3)+d_Liver_M*(age^4)+e_Liver_M*(age^5) Vliver = Vliver1*0.001 !(L)|Volume of the liver Vheart1 = y0_Heart_M +a_Heart_M*age+b_Heart_M*(age^2)+c_Heart_M*(age^3)+d_Heart_M*(age^4)+e_Heart_M*(age^5) Vheart = Vheart1*0.001 !(L)|Volume of the heart Vbrain1 = a_Brain_M*((age+ b_Brain_M)/(c_Brain_M+ d_Brain_M*age)) Vbrain = VBrain1*0.001 !(L)|Volume of the brain Vgonads1 = y0_Gonads_M +a_Gonads_M*age+b_Gonads_M*(age^2)+c_Gonads_M*(age^3)+d_Gonads_M*(age^4) Vgonad = Vgonads1*0.001 !(L)|Volume of the gonads Vplasmalg = a_VPlasma_M*log10(BW)+b_VPlasma_M Vplasmaa = 10^(Vplasmalg) Vplasma = Vplasmaa*0.001 !(L)|Volume of the plasma Else QC = y0_QC_F+a_QC_F*age+b_QC_F*(age^2)+c_QC_F*(age^3) !(L/h)|Cardiac Output Qbrain = y0_QBrain_F+a_QBrain_F*age+b_QBrain_F*(age^2)+c_QBrain_F*(age^3) !(L/h)|blood flow to the brain Vliver1 = y0_Liver_F +a_Liver_F*age+b_Liver_F*(age^2)+c_Liver_F*(age^3)+d_Liver_F*(age^4)+e_Liver_F*(age^5) !(ml)|Volume of the liver Vliver = Vliver1*0.001 !(L)|Volume of the liver Vheart1 = y0_Heart_F +a_Heart_F*age+b_Heart_F*(age^2)+c_Heart_F*(age^3)+d_Heart_F*(age^4)+e_Heart_F*(age^5) !(ml)|Volume of the heart Vheart = Vheart1*0.001 !(L)|Volume of the heart Vbrain1 = a_Brain_F*((age+ b_Brain_F)/( c_Brain_F+ d_Brain_F*age)) !(ml)|Volume of the brain Vbrain = VBrain1*0.001 !(L)|Volume of the brain Vgonads1 = y0_Gonads_F+a_Gonads_F*age+b_Gonads_F*(age^2)+c_Gonads_F*(age^3)+d_Gonads_F*(age^4) !(ml)|Volume of the gonads Vgonad = Vgonads1*0.001 !(L)|Volume of the gonads Vplasmalg = a_VPlasma_F*log10(BW)+b_VPlasma_F Vplasmaa = 10^(Vplasmalg) Vplasma = Vplasmaa*0.001 !(L)|Volume of the plasma ENDIF Qliver = QliverC(age) !(L/h)|Blood flow to the liver Vfat = VfatC(age) !(L) |Volume of the fat QFat = QFatC*QC !(L/h)|Blood flow to the fat QS = 0.24*QC - QFat-Qheart !(L/h)|Blood flow to the slowly perfused tissues QR = 0.76*QC - QLiver - Qgonad - Qbrain !(L/h)|Blood flow to the rapidly perfused tissues Qgonad = QgonadC*QC !(L/h)|Blood flow to the gonads QHeart = QHeartC*QC !(L/h)|Blood flow to the heart VS = 0.60*BW -VFat-Vheart !(L) |Volume of the slowly perfused tissues VR = 0.33*BW -VLiver-Vplasma -Vgonad-Vbrain !(L) |Volume of the rapidly perfused tissues !!!!!!!!!!!!!!!!!!!!!!!the rest codes are the same as the adult humans and adult and young monkeys!!!!!!!!!!!!!!!!!!!!!!!