Using Drosophila melanogaster To Identify Chemotherapy Toxicity Genes

Files in this data supplement:

  • Supporting Information: Figures S1-S4, Tables S1-S4, and Supporting Information References (PDF, 476 KB)
  • Figure S1: Density plots of the mean number of offspring produced by the three replicate females from each RIL cross for A) carboplatin, B) gemcitabine, and C) mitomycin C. (PDF, 158 KB)
  • Figure S2: Santa Cruz Genome Browser for the widest combined confidence interval (Table1) for QTLs A) CA, B) CB, C) GA, and D) GB. (PDF, 294 KB)
  • Figure S3: Association scans with carboplatin toxicity for all SNPs in candidate genes listed in Table S2. (PDF, 190 KB)
  • Figure S4: Association scans with gemcitabine toxicity for all SNPs in candidate genes listed in Table S2. (PDF, 138 KB)
  • Table S1: A priori identified Candidate Genes. (PDF, 85 KB)
  • Table S2: Candidate genes associated with QTL peaks of Figure XX and Table 1. (PDF, 113 KB)
  • Table S3: Biallelic SNPs significant after Bonferroni correction from gene-centric association scans. (PDF, 112 KB)
  • Table S4: Biallelic SNPs with p-values less than 0.01 for both gemcitabine toxicity and methotrexate toxicity within the GB1 candidate gene region (see Table S2). (PDF, 114 KB)