F
ControlEstradiolFulvestrant
Estradiol + fulvestrant
0.1
1
10
100
m
RNA
le
ve
l
β1
β1B
GREB1
***
E
MC
F-7
SKBR3 BT474
MDA-MB-231
0.1
1
10
100
1B
 m
R
N
A l
ev
el **
***
MCF-7SKBR3 BT474
MDA-MB-231
0.1
1
10
100
1000
1 m
R
N
A l
ev
el
***
***
***
DC
GPI PDCD2L UBA2 WTIP SCGBL ZNF302 ZNF599 ZNF30 ZNF792 GRAMD1A SCN1B HPN FXYD3 LGI4 FXYD1 FXYD7 FXYD5 FAM187B LSR USF2 HAMP
Ginestier
Lu
Richardson 2
TCGA
Zhao
665947 626289 602328 549718 437246 353048 272613 103785 74334 35904
0
9818 85140 93825 108136 112562 124033 1941
11
217967 238304 251818
0.65                                1.8
B
-10 -5 5 10
-2
-1
1
2
3
4
ESR1
SC
N
1B
A
-2
-1
0
1
2
3
4
Log2 m
edi
an-
cent
er
ed i
ntens
ity
ER- ER+