Parameter start values used for the initialization of the combined Bayesian-PBPK approach
parameter start values;;
;;
parameter;start value;unit
Intestinal permeability;0;cm/min
Intestinal transit time;240;min
Gastric emptying time;16.95;min
Luminal clearance factor;0.01;µM/min
kcat OATP1B1 (factor);503.7;-
kcat MRP2 (factor);2242.63;-
Measurement error;0.75;-
Lipophilicity (logP);56.06;%
Unbound protein fraction;223;µM
Km OATP1B1;11.5;µM
Lag Time of enterohepatic circulation;193.25;min