The Rockefeller University Press, doi: 10.1083/jcb.201408025
Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion
Podcast
biosights: November 24, 2014
Dynein helps centrioles stick together
The Rockefeller University Press
biosights{at}rockefeller.edu
Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles. This biosights episode presents the paper by Jones et al. from the November 24, 2014, issue of The Journal of Cell Biology and includes an interview with the paper's senior authors, Viki Allan and Sarah Woolner (University of Manchester, UK). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
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