Hybrid Incompatibility Despite Pleiotropic Constraint in a Sequence-Based Bioenergetic Model of Transcription Factor Binding

Files in this data supplement:

• Supporting Information: Figures S1-S3 and File S1 (PDF, 3 MB)
• Figure S1: Median net F2 hybrid misregulation in relation to population size and the evolutionary rate of the directionally selected trait (DeltaP_opt), for pleiotropic (clear boxes) and two-domain (gray boxes) models. (PDF, 1 MB)
• Figure S2: Median net F2 hybrid misregulation of the positively selected trait under varying selection strengths and mutation-effect sizes in the pleiotropic (clear boxes) and two-domain (gray boxes) models. (PDF, 1 MB)
• Figure S3: Median net F2 hybrid misregulation under varying mutation rates occurring at cis-regulatory sites of separate traits in the pleiotropic (clear boxes) and two-domain (gray boxes) models, with a motif length of 24 bits that results in a lower mutation effect size. (PDF, 1 MB)
• File S1: PDF, 75 KB