Published December 8, 2014 // JCB vol. 207 no. 5 577-587
The Rockefeller University Press, doi: 10.1083/jcb.201406135

An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion

Files in this Data Supplement:

  • Supplemental Material (PDF)
  • Video 1 -
    E-cadherin–GFP dynamics at cell–cell contacts. Cells stably expressing E-cadherin–GFP were transfected with scramble or Elmo2 siRNA. Cells were visualized by epifluorescence time-lapse microscopy. 1-s exposures captured over 1 h with a 1-min interval. Bar, 5 µm.
  • Video 2 -
    E-cadherin–GFP and LifeAct-RFP dynamics at cell–cell contacts. Cells stably expressing E-cadherin–GFP were transfected with LifeAct-RFP and scramble or Elmo2 siRNA. Cells were visualized by epifluorescence time-lapse microscopy. 1-s exposures captured over 30 min with a 1-min interval. Bar, 5 µm.