SMILES,Compound_ID,"EC50, nM","%inhibition in vivo 25 mg/kg b.i.d., p.o."
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(F)C=C5F)CC4)C=C3F)=O)NC6=CC=NC=C6,1,29±8,90.2±9.5
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(F)C(F)=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,2,17±1,87.4±14.9
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(Cl)C=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,3,9.9 ± 6.0,93.7±4.0
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(C(F)(F)F)C=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,4,92 ±8,96.8±1.8
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=CC=C5Cl)CC4)C=C3F)=O)NC6=CC=NC=C6,5,36 ±24,71.5±46.0
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(Cl)C(Cl)=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,6,12±2,N/D
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(Cl)C=C5Cl)CC4)C=C3F)=O)NC6=CC=NC=C6,7,2.2±1.2,N/D
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(C(F)(F)F)C=N5)CC4)C=C3F)=O)NC6=CC=NC=C6,8,2.7±0.3,N/D
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC(Cl)=CC(Cl)=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,9,1.9 ±0.9,99.8±0.2
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=C(C)C=CC(Cl)=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,10,1.6 ±1.3,99.9±0.4
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=CC(Cl)=C5Cl)CC4)C=C3F)=O)NC6=CC=NC=C6,11,2.0 ±1.3,98.7±2.0
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=CC=C(F)C(Cl)=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,12,4.4 ±2.7,98.6±1.4
O=C([C@@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(N4CCN(C5=C(OC)C=CC(Cl)=C5)CC4)C=C3F)=O)NC6=CC=NC=C6,13,17±9,80.3±9.6