Table 1. Fragments resulting from prediction clustering

Fragment

Start *

End*

Predicted sites

Activity

hA1

–28,992

–28,221

DR4, ER8

No

hA2

–27,545

–27,013

ER7

No

hA3

–25,028

–24,453

ER7(2x)

No

hA4

–24,213

–23,631

ER6

No

hA5

–22,915

–21,663

DR5, ER6, ER7(2x)

No

hA6

–21,183

–19,038

DR4, DR5(2x), ER7

Yes

hA7

–19,275

–18,308

DR3, DR5

No

hA8

–16,569

–15,652

DR3, DR4

Yes

hA9

–15,465

–14,992

DR3

No

hA10

–13,033

–12,501

DR5

No

hA11

–11,707

–11,153

ER8

No

hA12

–10,575

–9,592

DR4, ER6

No

hA13

–6,906

–6,347

DR3

No

Promoter

–1,249

–1

DR3, DR4(2x), DR5, ER6, ER8(2x)

No

*Relative to the ALAS1 transcriptional start site.

†Potential nuclear receptor binding sites within each fragment that fit the selection criteria.

‡Refers to the ability of the fragment to confer drug-mediated activation in reporter gene assays.