Pharmacological Inhibition and Genetic Knockdown of Exchange Protein Directly Activated by cAMP 1 Reduce Pancreatic Cancer Metastasis In Vivo

Data Supplement

Files in this Data Supplement:

• Supplemental Figures -

  Supplementary Figure 1 - EPAC1 and EPAC2 expression in MIA PaCa-2

  Supplementary Figure 2 - EPAC1 knockdown decreases invasion and migration of MIA PaCa-2

  Supplementary Figure 3 - Effects of utilized compounds on viability of MIA PaCa-2

  Supplementary Figure 4 - Luciferase activity in MIA PaCa-2 and MIA PaCa-2-Epac1-KD cells

  Supplementary Figure 5 - Inhibition or suppression of EPAC1 decreases the level of surface integrin beta-1

  Supplementary Figure 6 - PKC inhibition negates 007-AM's impact on MIA PaCa-2's migration and trafficking of integrin beta-1