Adaptation of Pandemic H2N2 Influenza A Viruses in Humans

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Text S1 (Full methods summary.)

  Fig. S1 (Maximum likelihood trees of the PB2, PB1, PA, HA, NP, NA, M, and NS segments used in this study.)

  Fig. S2 (Temporal phylogenies of human H2N2 virus gene segments and associated avian H2N2 or human H1N1 sister clades.)

  Fig. S3 (Significant positively selected sites plotted on the crystal structure of the A/Singapore/1/1957(H2N2) virus HA trimer; observed-to-expected CpG ratios in each segment of the human H2N2 isolates and respective background/sister clade.)

  Table S1 (GenBank accession numbers.)

  PDF, 7.1M