Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells

Supplemental material

Files in this Data Supplement:

• Supplemental file 1 -

  Fig. S1 (β8 integrin subcellular localization and primary amino acid sequence), S2 (FRET imaging components), S3 (PTP-PEST and MEF migration), S4 (Integrin-mediated neural cell migration ex vivo), S5 (Neuroblast migration defects), S6 (Inhibition of PTP-PEST catalytic activities and cell migration ex vivo), S7 (Inhibition of Tiam1 and cell migration defects), S8 (β8 integrin and perivascular neural cell migration), and S9 (Cell migration in the RMS); legends to Movies S1 to S4; and supplemental text

  PDF, 4.9M

• Supplemental file 2 -

  Movie S1 (Suppression of Cdc42 activation)

  AVI, 633K

• Supplemental file 3 -

  Movie S2 (β8 integrin and Rac activation)

  AVI, 670K

• Supplemental file 4 -

  Movie S3 (β8 integrin and Cdc42 activation)

  AVI, 2.1M

• Supplemental file 5 -

  Movie S4 (β8 integrin and Rac activation)

  AVI, 3.7M