A) This is a TBLASTN output for SPRAG1L against the green sea urchin Scaffold19893. It is evident that the LVRAG1L-coding region is corrupted by two frameshifts and 4 stop-codons. The ~270-aa N-terminal part of SPRAG1L is missing. Query= SPRAG1L (983 letters) Database: scaffold19893 1 sequences; 12,807 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Scaffold19893 356 e-155 >Scaffold19893 Length = 12807 Score = 356 bits (913), Expect(3) = e-155, Method: Compositional matrix adjust. Identities = 190/389 (48%), Positives = 254/389 (65%), Gaps = 2/389 (0%) Frame = -1 Query: 420 AEKYSFLKSKGDKTFRPPGQLTKRESCYMPGNVRFGLMEGGKCVYHTPEKSLEEFDDHSM 479 AE+Y +LKSKGD + + + C + +++ + T + S F D Sbjct: 7086 AEQYHYLKSKGD--HQVLWTIARHRICQEVLVLA*WMLQR---TFITHQSSPT*FKDRLE 6922 Query: 480 YEPIRINVRSKLTEFA--LPNCIGVAWSYPEAVAKTLEELDENIREGMLKVGLNPDGPSI 537 + + L F+ +GVAWSY AVAKTLEELD I + + + GL D I Sbjct: 6921 LVTMSLI**EDLQRFSSLQSQTVGVAWSYRAAVAKTLEELDSIIEKNIHENGLAED---I 6751 Query: 538 IIDTTLKDGADGMGEIAVHKMKSDTFLPDKAFRASFVVLKCEVKRDDGTRDLVFEEPKPN 597 +I T LKDGADGMG+IAVH+ SDT+LPDKAFRASFVVL E DDG+ ++FEE +PN Sbjct: 6750 VIHTMLKDGADGMGDIAVHRGSSDTYLPDKAFRASFVVLNSEAMADDGSWIILFEEERPN 6571 Query: 598 SVIVNRPLLEAIGDENSASTSAVLMRKMEKERLILQNSIMTIHAGTYTRLHRFTIYNSMI 657 +V VNRP+LEAIGD N STSA L+R +E ER ++Q M I+ + TR H+ IYNSMI Sbjct: 6570 AVQVNRPILEAIGDVNRPSTSAQLLRGIEWERRMMQVKTMKIYTASSTRSHKLRIYNSMI 6391 Query: 658 DEKLARSSGGLQGSGSNFICTLCHATKTSAKTQLGSFKIDRTLTETQQTLTYITTNPDNL 717 DEKL R+ GGLQGSGS ++CTLCHAT+ +AKTQ+G+F IDR+ E Y+ NPD L Sbjct: 6390 DEKLDRADGGLQGSGSRYLCTLCHATRETAKTQIGTFCIDRSFQEISDMGQYLEVNPDKL 6211 Query: 718 TPDELTTEAGGVKRKPLLTSEPKQQLMDATHADIDLGQFFKKIIVREMAGVHKWEASENV 777 + +L +A GV S+P+ +L+DATHADI+L QF KK+I+RE+AGV W+A +V Sbjct: 6210 SSVDLAEQAKGV-------SDPRMKLVDATHADINLSQFLKKLIIREIAGVQMWDAGNDV 6052 Query: 778 KQYIVDAERRLNINVRELLGTAPSLMMPG 806 K+YI DAE+RLN +++ +G AP+LMMPG Sbjct: 6051 KEYIEDAEKRLNDHIQATIGLAPNLMMPG 5965 Score = 160 bits (406), Expect(3) = e-155, Method: Compositional matrix adjust. Identities = 74/120 (61%), Positives = 90/120 (75%), Gaps = 2/120 (1%) Frame = -2 Query: 861 FKKKAVQIGRELLEHFEYVCWPNYLHKIFEHTQEAMLSEDGPGSIGILSSEGSEAANKLF 920 +K AV +G +L+++F YV WP+YLHKI EH QE + GPGSIG LS EGSEAANKLF Sbjct: 5804 YKYTAVNMGMKLIDNFSYVSWPSYLHKIIEHVQEVLEDPQGPGSIGSLSGEGSEAANKLF 5625 Query: 921 RKLRNNFSRRGDVLDGLRDILWFHWLYTSPKLVRLRA--VTRGTYTCSRCGAEGHNKKSC 978 R LR + +RRG V DGLRD+LW HWL+TSPKL LRA + R Y CS+CGAEGH+K +C Sbjct: 5624 RHLRKHAARRGVVSDGLRDVLWMHWLFTSPKLQSLRAASLVRRKYHCSKCGAEGHSKTTC 5445 Score = 62.0 bits (149), Expect(3) = e-155, Method: Compositional matrix adjust. Identities = 31/53 (58%), Positives = 36/53 (67%) Frame = -3 Query: 806 GNYARALFKEKNEDVFLELIRNEERKELLRSVLQKFRALRKIYREHHPNKREV 858 GNYARALF NE FL LI N++R+ L+SVL FR LR+IYRE P EV Sbjct: 5968 GNYARALFDAANESTFLGLIPNQDRRSYLQSVLADFRFLRRIYRERKPEAEEV 5810 Score = 55.5 bits (132), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/189 (28%), Positives = 80/189 (42%), Gaps = 5/189 (2%) Frame = -1 Query: 271 TATASLTPTAT---APLPPTATALLTPTATRYRPIVTKDRAPFTRALFSPVLTVPA--RK 325 + T SL T+T A LP T + + T +RP+ +K A TR LF+P + R Sbjct: 8028 SQTKSLASTSTLSEASLPFTEQH--STSTTNFRPVQSKTPAEVTRKLFAPQTELQGLKRV 7855 Query: 326 SPARAKGSLHYVRRDCAKNRARGALDFMTSHSAAKNENETDLWFFGLHNRLRNEEDERAK 385 K LH V RD A+ R + A D +T + E+E D+ FF L ++ +D R K Sbjct: 7854 KVWDVKERLHAVGRDYARKRIKKASDSLTEFCESHKEDEIDVMFFLLEDKFVRSKDYRHK 7675 Query: 386 MVMELWTERKKSTDLSVDDCLAMRVGTLCTKGMYAEKYSFLKSKGDKTFRPPGQLTKRES 445 V R+ LS+ CL + + C + Y + G ES Sbjct: 7674 SV------RRIVYILSLFFCLHL---SFCCNNFRIQNYILICR*G----------IVHES 7552 Query: 446 CYMPGNVRF 454 C +P +F Sbjct: 7551 CVLPVQEQF 7525 B) Prediction of LVRAG2L in combo2, assembled from Scaffold19873 and Scaffold71 FGENESH 2.6 Prediction of potential genes in Strongylocentrotus_purpuratus genomic DNA Seq name: combo2 Length of sequence: 6290 Number of predicted genes 1: in +chain 0, in -chain 1. Number of predicted exons 3: in +chain 0, in -chain 3. Positions of predicted genes and exons: Variant 1 from 1, Score:35.348602 G Str Feature Start End Score ORF Len 1 - PolA 1141 1.86 1 - 1 CDSl 1395 - 2245 21.44 1395 - 2243 849 1 - 2 CDSi 3813 - 4067 12.62 3814 - 4065 252 1 - 3 CDSf 4593 - 4890 7.41 4594 - 4890 297 1 - TSS 5324 -5.00 Predicted protein(s): >FGENESH:[mRNA] 1 3 exon (s) 1395 - 4890 1404 bp, chain - ATGGATGCGTTCTCTGACTTTGATATGATTGTTCTTAAAGCCTCAAAGCAAAATAAAAGA AATATATCAAGGAAAAAAACTCAATTAGATATTAAGATTGGAGAAAGTTACCCTCCAGAA GGGCATTGTTCGATTAAAGATTCAGAAACAGAAGAGCAAGTGAGGATTTTCTGTTTTGGT GGAGCTCGTCGTGGAGAGGATACCTCATGGATCGAATCATCAAACATACTTGAATTTATA TTGAAGGTTGATGATGATAATGCTATAATATCATCCATTATGCCTTGCAAAACCAAGGGT GGGACACTACCCCCATTACAGTCAGCAGCTGTGATTGAATACAACGGGCGTTTCCTTGTA TGGGGAGGACTTGACCTCGCTCATTATGAATGTAGGGATGACTTGATCATATTAGAAAAA ATGGAAGGGACTTCCCAAGGCCGGGCAACACCCTCAACAACTTTTGATGTTACGTATGTA CAGACAAGAAAAAATATGGTACCATCAAGAAGAGGGGCCATCTTGGATGAACAAACAGGG ACAGTACCTCAAGCCAGGACGGGTCACAGCCTCACCCAGCTTGGAAATACAACAAATGCA ATATTGTTTGGCGGTGTAATATATGAAAGACAAGAAAGAGGATTCACACTTCAATGGGAG AAGTCCTGTCAAGATGGTAGGTTTTATGTTCTTGAAATGGAGACGCTTTCATGGAGCCTG ATCAAAGTACCATCAACTCAAGCAAGAGCATATCACTCGGCTAACTGTATTGAAAAAGAT GGAACATTGGTTCTAGTGATTGTGGGTGGACTCACATTTAATAAGGGAAGCAGCATGATG GCGAAAAACCGAGAACCTATTCATGAGGTTCTGGTTTTGACAATGAACCTTGATTTTGTC AATCCAATCCTACAAACAGTAACATTAGAAGCTGGAAGTGCCCAGACATCACCTGTGTAT TTGTCATATCATGCAACATCAGTAGTAGGTAATTCAATATTAGTGTATGGTGGATTTCAA CAAGAAAGCAGTGCAGTGAACCAAAACATTGCTTCAACACGGGTGTATCAACTTGACATT GAAAGTCGGCTCTATTGCCTACTCTCTAAAACTGCTAAACATGCAAAGCACTCAGTATTT GCTACAGCAGGTCATACTCTGATCAATACAAATAATGACTTTGTGTGTATTGGAGGTACC TCAAAACAAATATCAATTTTGTCAGACAGAAACTTTGAAGAAGATAACTGTGACTTAGCA ACATGCCATATTCAGGATGCAGAAGATATTGAAATTGGATGGATCCATTGTGAAGCTCCA CGATGTGGAAAATGGTTTCATGAATTCTGTTTAGGATTAAAGCGCATTCCAGCCAAATAT TACTGTTCGGCATGCAAAAAATAG >LVRAG2L 1 3 exon (s) 1395 - 4890 467 aa, chain - MDAFSDFDMIVLKASKQNKRNISRKKTQLDIKIGESYPPEGHCSIKDSETEEQVRIFCFG GARRGEDTSWIESSNILEFILKVDDDNAIISSIMPCKTKGGTLPPLQSAAVIEYNGRFLV WGGLDLAHYECRDDLIILEKMEGTSQGRATPSTTFDVTYVQTRKNMVPSRRGAILDEQTG TVPQARTGHSLTQLGNTTNAILFGGVIYERQERGFTLQWEKSCQDGRFYVLEMETLSWSL IKVPSTQARAYHSANCIEKDGTLVLVIVGGLTFNKGSSMMAKNREPIHEVLVLTMNLDFV NPILQTVTLEAGSAQTSPVYLSYHATSVVGNSILVYGGFQQESSAVNQNIASTRVYQLDI ESRLYCLLSKTAKHAKHSVFATAGHTLINTNNDFVCIGGTSKQISILSDRNFEEDNCDLA TCHIQDAEDIEIGWIHCEAPRCGKWFHEFCLGLKRIPAKYYCSACKK C) BLASTP-based similarity between the 467-aa LVRAG2 and 499-aa SPRAG2 Query= LVRAG2L 1 3 exon (s) 1395 - 4890 467 aa, chain - Length=467 Sequences producing significant alignments: (Bits) Value Query_149597 SPRAG2L NP_001028184.1 recombination activating ... 430 3e-150 ALIGNMENTS >lcl|Query_149597 SPRAG2L NP_001028184.1 recombination activating protein 2-like [Strongylocentrotus purpuratus] Length=499 Score = 430 bits (1105), Expect = 3e-150, Method: Compositional matrix adjust. Identities = 231/481 (48%), Positives = 315/481 (65%), Gaps = 25/481 (5%) Query 1 MDAFSDFDMIVLK-ASKQNKRNISRKKTQLDIKIGESYPPEGHCSIK-----DSETEEQV 54 M++ DF MI+L+ ASK+ KR ISRKK Q D+K+ E Y EGH ++ E E++ Sbjct 1 MESLDDFGMILLQQASKEGKRKISRKKPQSDLKLNEYYLAEGHFAVMCPVLGAEEPEKKK 60 Query 55 RIFCFGGARRGEDTSWIESSNILEFILKVD-DDNAIISSIMPCKTKGGTLPPLQSAAVIE 113 RIF GGARRG D SW ++ I+E+++++D +D+ ++S++ CKT GG +P LQSAA IE Sbjct 61 RIFSSGGARRGGDNSWGDAGRIIEYVVEMDKNDDVTLASVVSCKTTGGRMPALQSAAAIE 120 Query 114 YNGRFLVWGGLDLAHYECRDDLIILEKMEGTSQGRATPSTTFDVTYVQTRKNMVPSRRGA 173 + RF VWGG DL Y C+DDLIILE EG +G AT + FD+ YV T NMV SRRG Sbjct 121 SDSRFYVWGGFDLMEYRCKDDLIILE--EGRRRG-ATGAPVFDIKYVPTTANMVASRRGN 177 Query 174 ILDEQTGTVPQARTGHSLTQLGNTTNAILFGGVIYERQERGFTLQWEKSCQDGRFYVLEM 233 + Q GTVP ARTGH+LT+LG T A+LFGGV+ + + + F+++WE +C+DG FY+L++ Sbjct 178 TVPVQKGTVPHARTGHTLTRLGETKEALLFGGVMEQEERKSFSVEWELACRDGTFYILDL 237 Query 234 ETLSWSLIKVPS-TQARAYHSANCIEKDGTLVLVIVGGLTFNKGSSMMAKNREPIHEVLV 292 +T W + VPS T AR YH+A C+E + V+ VGG+ +K ++ R PI+EVL+ Sbjct 238 DTFIWRRVPVPSATLARTYHTAECLETVRSFVIAFVGGVMHDKNTT----TRIPINEVLL 293 Query 293 LTMN-LDFVNPILQTVTLEAGSAQTSPVYLSYHATSVVGNSILVYGGFQ-QESSAVNQNI 350 LTMN D +L TVTL + T Y+SYHAT+ V +ILV GGFQ Q SS + + Sbjct 294 LTMNSQDTDTAVLSTVTLASDGPSTPVPYISYHATAQVNYNILVSGGFQLQHSSDIPKTS 353 Query 351 --ASTRVYQLDIESRLYCLLSKTAKHAKHSVFATAGHTLINTNND-FVCIGGTSKQISIL 407 AS+RV+ LDI + Y LL KT + + F TAGH L+ D + +GGTSKQIS+L Sbjct 354 RHASSRVFILDIVGKKYKLLPKTQNNNQ---FGTAGHVLLTLAPDCIISVGGTSKQISML 410 Query 408 SDRNFEEDNCD-LATCHIQDAE-DIEIGWIHCEAPRCGKWFHEFCLGLKRIPAKYYCSAC 465 SDR ++ + CD L +C I +AE +EI W+ CE PRCGKW H +CL L IP Y+C C Sbjct 411 SDRKYKPEKCDLLPSCTIAEAEGTVEIQWVQCETPRCGKWVHVYCLKLNSIPEIYFCPHC 470 Query 466 K 466 K Sbjct 471 K 471 D) DNA sequence of combo2 ; FRAGMENT 2348 -> 1 ;Scaffold19893 ; FRAGMENT 88755 -> 92664 ;Scaffold71 >combo2 TCAGCTTATTGATTTTTAAGGTATCATCGTCATTTTGGTAAATTCAGATATATTGTTTGTATCAAGTTGA CCACTATTGCCCCTGAAAATGATGGATGCATATACAGTAGTCAATAAAAAACAAATAAACAATATACATG TACAGTGTAATAAAGTTTTCATATGATAACATATTTTTATTGCTTATTCTGTACAGCTATTTGAATTTGA AAAGTATGAATCTTGAATTATTATTATAATAGTCTTACCTACATTCGATGTTATGTTTATACTGTATGAC AAATTGTTGAAGCTGAGCATTCAGTATCAGAGATAATGACCAAGCATTTCTGTTATTTCTGTTTTATTTA ACTTTATTACAGCTTTTAATTTGCCTAAAACTTTTAAAAAAAGGTAAAGCCCACCCGAACAGAAAGGTTG ATGTGAAGAATTGTTAGAAAAACCAAACAAGCATGAAGCTGAAAATGGAAATATTTATATAACTTATGCA GAAAAGTAATATATCATAAGCTTCATGTATTGGCTTCAGTAATGTAACAAAATAATGCTGCTGATAATGC TTTGATTGCCATTGAAGTTTTTATTATTCAATCGAATTTTCGATGGTCCTACGTCTTTTTCAGGAGTTTA CAATGTGGTATTACATGTAGATCAATCATAGATCGTATCCTCAGTTGTTTCTGTTATTAAAGCAATATCT GTCTGAGGTTGCGCTCTCTGATTGATCTAATACCACATTGTAAACTCTTGAAGAAGACGGGGGATTGTTG AAAATTTAAGTGAATAAACAGCTTCATTAGCAATTAAAGCATTATCAGCTTTATTTTGTGTGTATAATAA TCACAAATAGTTTAGAAAATGCCGTAGAAATAAAATTGTTTTAAAAGAAGCATAGCTCTCAAAATAGCTC TCCTTTCAAAATATATCATGATTTTATTTCTACGGCATTTCCTAAACTATTCTTGATTATTTTATTTCAT ATGCCAAAGCAGACTATTGTATGATCTTCTCGCTCAGTAACTCCATCACCTCTTTTTTTTGTAAAAAGTA ACCCCATACACATAACTAGGTGAAATGTCCCAATTTCTTAACCTTAGGATTATCCTATAACAAATTTTGA TGTTCTCTATTTGGTTCCTATTTATTAGGGTGAACTTATACCTTTACAAAACATGAAATCTCTTGCTGTA AAAGCTAATAAGCTATCGATCCAAAGCAATATACTAAAATCAAATGGCAAGTCTATTTTATGGTGGATAA TGAAAATACAATGTATGAACCATTTCATGGCCAATGACTGTGTTTAATAACATGCCACATCCTCAGATTT TAGTTCTGCTTTTATCATCTAACAATTATGTGGGTAATTTGGATTGGTCATTCATCTCTATGACCTATTT TTTGCATGCCGAACAGTAATATTTGGCTGGAATGCGCTTTAATCCTAAACAGAATTCATGAAACCATTTT CCACATCGTGGAGCTTCACAATGGATCCATCCAATTTCAATATCTTCTGCATCCTGAATATGGCATGTTG CTAAGTCACAGTTATCTTCTTCAAAGTTTCTGTCTGACAAAATTGATATTTGTTTTGAGGTACCTCCAAT ACACACAAAGTCATTATTTGTATTGATCAGAGTATGACCTGCTGTAGCAAATACTGAGTGCTTTGCATGT TTAGCAGTTTTAGAGAGTAGGCAATAGAGCCGACTTTCAATGTCAAGTTGATACACCCGTGTTGAAGCAA TGTTTTGGTTCACTGCACTGCTTTCTTGTTGAAATCCACCATACACTAATATTGAATTACCTACTACTGA TGTTGCATGATATGACAAATACACAGGTGATGTCTGGGCACTTCCAGCTTCTAATGTTACTGTTTGTAGG ATTGGATTGACAAAATCAAGGTTCATTGTCAAAACCAGAACCTCATGAATAGGTTCTCGGTTTTTCGCCA TCATGCTGCTTCCCTTATTAAATGTGAGTCCACCCACAATCACTAGAACCAATGTTCCATCTTTTTCAAT ACAGTTAGCCGAGTGATATGCTCTTGCTTGAGTTGATGGTACTTTGATCAGGCTCCATGAAAGCGTCTCC ATTTCAAGAACATAAAACCTACCATCTTGACAGGACTTCTCCCATTGAAGTGTGAATCCTCTTTCTTGTC TTTCATATATTACACCGCCAAACAATATTGCATTTGTTGTATTTCCAAGCTGGGTGAGGCTGTGACCCGT CCTGGCTGAAAAAAAGAAATTAAAAAAATAACTGCATGCATTTGCACCTTCAGAGGAGTTTATAAGGTTC TGTTTTAATATGTAAGATACATTACATTCAGAAGCTTANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN CTCTTCCACACCCGCGGGCGGCATGTGGAAGGACACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTTTAAA TGTGTTTCATATTTTTATAAGTTCATGTTTACCTTGAGGTACTGTCCCTGTTTGTTCATCCAAGATGGCC CCTCTTCTTGATGGTACCATATTTTTTCTTGTCTGTACATACGTAACATCAAAAGTTGTTGAGGGTGTTG CCCGGCCTTGGGAAGTCCCTTCCATTTTTTCTAATATGATCAAGTCATCCCTACATTCATAATGAGCGAG GTCAAGTCCTCCCCATACAAGGAAACGCCCGTTGTATTCAATCACAGCTGCTGACTGTAATGGGGGTAGT GTCCCACCTGTTGAATAAATTGTAACATCAAGGCGTTATTCATTCATATCAAAAGTCTTAACCTTGTTTG TTTAAATTTGTGTAACTCTTTTGCATGTTTGAAACTGCTAAACTATATAGCCGTTTGTGATGAATTATGA GTATGAAATAACGAAGATGAAATTGAAAGATGGAGTAAGTGCGTGAGAGACTTGAGAAGATTGTTAATAA TGTCTTGCAAAATAACTAATGAAACATACAAATTCCATACTACTAAACATGATTATGAACCTGAATGCTT TTGGAACGGAATGGAATGAGCTGAGAAAAACAGTTCAAACACTAAGCAGAAGAAAATGTGAATGAATAAA GAATGCAAAGTGTGAAAATGATTTATTTCATATCCAACATACTAGCAGTTGGAAATCACCTTGTTTGTAC ATTATTTTACATATACAATCTTCATCTTAATAATAAAAAACAGGCAAAACATCATTCATGTACAATAATT ATAAAAACGGTGCATATATAAAAGCTCTGGAAATTAACTCACCCTTGGTTTTGCAAGGCATAATGGATGA TATTATAGCATTATCATCATCAACCTTCAATATAAATTCAAGTATGTTTGATGATTCGATCCATGAGGTA TCCTCTCCACGACGAGCTCCACCAAAACAGAAAATCCTCACTTGCTCTTCTGTTTCTGAATCTTTAATCG AACAATGCCCTTCTGGAGGGTAACTTTCTCCAATCTTAATATCTAATTGAGTTTTTTTCCTTGATATATT TCTTTTATTTTGCTTTGAGGCTTTAAGAACAATCATATCAAAGTCAGAGAACGCATCCATTTTGCAAGCA TATATGCACATGTGAACTTTAATTGGAGGCTGACAGCGCAATATTGAGTTGTGACAAGTAGATGGTCTCG ATGCCTGTTTTTGCATCAGTCCAAGTGCAGGTAGAGAGTGAGAGACAACAGAGTGCAGAGCTGAGCTGAG CCTGTTTATTTACTTTTTGATAATCCCTGATAAAGTGATAGCCAGTCCAGCTTTACCCCCTGCTCTTGTA TGTCTATCTGCACATGAATTCTCTACATTCCAGGACCAAGTAAAATTTAAACTCCATCAATAATGATTTA AATACATGCATGATGTGTTATATGGGTACATAATTATCTATAGAATAATTGTAATACTTGAATAACATGT CATGGCCAGATTTGCATTTTTTTTCTTTCATTTTTTCCAAATATATATCTGAAATGTTTAGGATTTTTTT AAATGTCCACAGTTAATTCAAACCAGTTACTCTTGTTATATATTACAAACCTTCCACTACATACACTTTA TCACTTTCTACTTCAATAAAATTAGTATTAAAGTGAGGGGGGGGGGTACACCCACAACAAAAATTAATGT GACATAATATCCCAGAATCTAGACCCCAGTTCATGTCACCCTAATATTTAACACATTAAACAAGAACCAC TGACTTGCATAAGGGGGATCGCTGTAGAGTTAGAGAATCATTTTATTATTCATTAAAGATCAAAAGGAAA ATGGAAATGGATAATTTTCATAANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTCACCGCCTATGAACTGGTAGGCCTACGAGGGAGGG GCATGATGTTGTCCAAATATTTATTCAGTTCATGCTTTTTTAAATCATGTTTATCTCCATAAATATCAAT ATTTAAATATCTCTAAATCATAACAAATTCAATGATTGATTTCTCTTAAAATTATTTTCTCTAAAAATTA ATGAAACATTCTTTAAGAGCGCATAATAACAATGCATCAGCAGCTTACACAGGATTTTTCAAGGGGGGGA GGGTTCACTTCATGTTGACAACCCCCCCTCCAAAAAAAAAATCTTCACCACCAATTTAAGGTCAAATAAT ATTGTTAATATTCAAGGGGGCCGGGGGGGTTGGGTATCAAATAAATTTAAGGGGTTGGAACCCCTACCAC CACTGGGTATGTTAATGTGATGCATGCAAATCCTCAAAGAATTAATCAAGCCAAATATAAAACTATCAAA TTGTTAGTTAAGATAAACCAGTTAGAAGAAGTGAGAAAGCTAAAGCATGCATACATGCAG