############################################################################## # # # This CIF contains the data in a paper accepted for publication in # # Acta Crystallographica Section E. It conforms to the requirements of # # Notes for Authors for Acta Crystallographica Section E, and has been # # peer reviewed under the auspices of the IUCr Commission on Journals. # # # # Full details of the Crystallographic Information File format # # are given in the paper "The Crystallographic Information File (CIF): # # a New Standard Archive File for Crystallography" by S. R. Hall, F. H. # # Allen and I. D. Brown [Acta Cryst. (1991), A47, 655-685]. # # # # The current version of the core CIF dictionary is obtainable from # # ftp://ftp.iucr.org/pub/cif_core.dic. # # # # Software is freely available for graphical display of the structure(s) # # in this CIF. For information consult the CIF software page # # http://www.iucr.org/resources/cif/software. # # # # This file may be used for bona fide research purposes within the # # scientific community so long as proper attribution is given to the journal # # article from which it was obtained. # # # ############################################################################## data_global _audit_creation_method 'APEX2 v2014.5-0' _journal_data_validation_number ? _journal_date_recd_electronic 2015-03-24 _journal_date_accepted 2015-04-06 _journal_name_full 'Acta Crystallographica, Section E' _journal_year 2015 _journal_volume 71 _journal_issue 5 _journal_page_first 466 _journal_page_last 472 _journal_paper_category GO _journal_paper_doi 10.1107/S2056989015006854 _journal_coeditor_code IS5395 _publ_contact_author_name 'Oishi, Takeshi' _publ_contact_author_address ; School of Medicine, Keio University, Hiyoshi 4-1-1, Kohoku-ku, Yokohama 223-8521, Japan ; _publ_contact_author_email oec@keio.jp _publ_contact_author_fax '(81) 45 566 1311' _publ_contact_author_phone '(81) 45 566 1311' _publ_section_title ;\ Crystal structures of (+-)-(1SR,5SR,6SR,7SR,10SR,11SR,\ 13RS,14SR)-13-hydroxy-7-methoxymethoxy-11,15,18,18-\ tetramethyl-3-oxo-2,4-dioxatetracyclo[12.3.1.0^1,5^.0^6,11^]octadec-15-en-10-yl benzoate, its 13-epimer and 13-one derivative ; loop_ _publ_author_name _publ_author_address 'Oishi, Takeshi' ; School of Medicine, Keio University, Hiyoshi 4-1-1, Kohoku-ku, Yokohama 223-8521, Japan ; 'Fukaya, Keisuke' ; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan ; 'Yamaguchi, Yu' ; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan ; 'Sugai, Tomoya' ; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan ; 'Watanabe, Ami' ; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan ; 'Sato, Takaaki' ; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan ; 'Chida, Noritaka' ; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan ; _publ_section_synopsis ; In the title three compounds, the ring conformations of tetracycles are similar; each tetracycle adopts essentially planar, chair, half-chair and chair--chair forms. In the crystals, molecules are linked into similar chains by intermolecular hydrogen bonds. ; data_A _database_code_depnum_ccdc_archive 'CCDC 1057983' _chemical_name_systematic ;\ (+-)-(1SR,5SR,6SR,7SR,10SR,11SR,\ 13RS,14SR)-13-Hydroxy-7-methoxymethoxy-11,15,18,18-\ tetramethyl-3-oxo-2,4-dioxatetracyclo[12.3.1.0^1,5^.0^6,11^]octadec-15-en-10-yl benzoate pentane 0.25-solvate ; _chemical_name_common ? _chemical_formula_moiety 'C29 H38 O8, 0.25(C5 H12)' _chemical_formula_sum 'C30.25 H41 O8' _chemical_formula_iupac 'C29 H38 O8, 0.25C5 H12' _chemical_formula_weight 532.64 _chemical_melting_point 509.2 _space_group_crystal_system triclinic _space_group_name_H-M_alt 'P -1' _space_group_name_Hall '-P 1' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, -y, -z' _cell_length_a 11.3343(5) _cell_length_b 15.4666(7) _cell_length_c 16.4870(8) _cell_angle_alpha 85.1124(14) _cell_angle_beta 78.3773(14) _cell_angle_gamma 78.5231(15) _cell_volume 2771.3(2) _cell_formula_units_Z 4 _cell_measurement_reflns_used 9428 _cell_measurement_theta_min 2.44 _cell_measurement_theta_max 25.01 _cell_measurement_temperature 90.0 _exptl_crystal_description prism _exptl_crystal_colour colorless _exptl_crystal_size_max 0.320 _exptl_crystal_size_mid 0.210 _exptl_crystal_size_min 0.170 _exptl_crystal_density_diffrn 1.277 _exptl_crystal_density_meas ? _exptl_crystal_density_method 'not measured' _exptl_crystal_F_000 1146 _exptl_absorpt_coefficient_mu 0.091 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; (SADABS; Bruker, 2014) ; _exptl_absorpt_correction_T_min 0.97 _exptl_absorpt_correction_T_max 0.98 _exptl_special_details ; M.p. 507.2--509.2 K (not corrected); IR (film) 3502, 2950, 1799, 1717, 1451, 1272, 1098, 1055, 713 cm^-1^; ^1^H NMR (500 MHz, CDCl~3~) \d (p.p.m.) 8.03--8.00 (m, 2H), 7.60--7.55 (m, 1H), 7.48--7.43 (m, 2H), 5.50 (bs, 1H), 4.78 (d, J = 7.2 Hz, 1H), 4.71 (dd, J = 11.3, 4.3 Hz, 1H), 4.58 (d, J = 7.2 Hz, 1H), 4.50 (d, J = 3.7 Hz, 1H), 4.31 (dd, J = 9.0, 2.0 Hz, 1H), 3.56 (ddd, J = 10.7, 10.7, 5.2 Hz, 1H), 3.35 (s, 3H), 2.87 (bd, J = 18.3 Hz, 1H), 2.41--2.30 (m, 2H), 2.11 (s, 1H), 2.08 (dd, J = 10.7, 3.7 Hz, 1H), 1.89 (dddd, J = 12.7, 4.3, 4.0, 4.0 Hz, 1H), 1.77 (s, 3H), 1.72--1.50 (m, 4H), 1.29 (s, 3H), 1.25 (s, 3H), 1.17 (s, 3H); ^13^C NMR (125 MHz, CDCl~3~) \d (p.p.m.) 165.9 (C), 154.1 (C), 136.7 (C), 133.4 (CH), 130.3 (C), 129.7 (CH), 128.6 (CH), 120.9 (CH), 97.8 (CH~2~), 87.1 (C), 80.0 (CH), 78.1 (CH), 75.0 (CH), 67.1 (CH), 60.6 (CH), 55.9 (CH~3~), 47.8 (CH~2~), 46.2 (CH), 42.6 (C), 40.2 (C), 31.9 (CH~2~), 31.2 (CH~2~), 25.9 (CH~3~), 25.1 (CH~3~), 24.7 (CH~2~), 19.8 (CH~3~), 13.6 (CH~3~); LRMS (EI) m/z 514 (M^+^, 4%), 483 (1), 469 (1), 453 (1), 409 (4), 393 (12), 348 (1), 332 (1), 121 (83), 105 (100), 77 (67); HRMS (EI) m/z calcd for C~29~H~38~O~8~^+^ [M]^+^ 514.2567, found 514.2545. ; _diffrn_ambient_temperature 90.0 _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_radiation_monochromator 'multilayered confocal mirror' _diffrn_measurement_device_type 'Bruker D8 Venture' _diffrn_measurement_method '\f and \w scans' _diffrn_detector_area_resol_mean 8.333 _diffrn_reflns_number 50997 _diffrn_reflns_av_R_equivalents 0.0411 _diffrn_reflns_av_sigmaI/netI ? _diffrn_reflns_theta_min 2.21 _diffrn_reflns_theta_max 25.03 _diffrn_reflns_theta_full 25.03 _diffrn_measured_fraction_theta_max 0.993 _diffrn_measured_fraction_theta_full 0.993 _diffrn_reflns_limit_h_min -13 _diffrn_reflns_limit_h_max 13 _diffrn_reflns_limit_k_min -18 _diffrn_reflns_limit_k_max 18 _diffrn_reflns_limit_l_min -19 _diffrn_reflns_limit_l_max 19 _diffrn_standards_number 0 _diffrn_standards_interval_count ? _diffrn_standards_decay_% ? _refine_special_details ; Refinement of F^2^ against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F^2^, conventional R-factors R are based on F, with F set to zero for negative F^2^. The threshold expression of F^2^ > \s(F^2^) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F^2^ are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. Problematic three reflections with |I(obs)-I(calc)|/\sW(I) greater than 10 (1 1 0, 9 9 11 and 5 3 11) have been omitted in the final refinement. ; _reflns_number_total 9735 _reflns_number_gt 7339 _reflns_threshold_expression 'I > 2\s(I)' _refine_ls_structure_factor_coef Fsqd _refine_ls_matrix_type full _refine_ls_R_factor_all 0.0636 _refine_ls_R_factor_gt 0.0400 _refine_ls_wR_factor_gt 0.0869 _refine_ls_wR_factor_ref 0.0989 _refine_ls_goodness_of_fit_ref 1.023 _refine_ls_restrained_S_all 1.023 _refine_ls_number_reflns 9735 _refine_ls_number_parameters 726 _refine_ls_number_restraints 0 _refine_ls_number_constraints ? _refine_ls_hydrogen_treatment constr _refine_ls_weighting_scheme calc _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0390P)^2^+1.4256P] where P=(Fo^2^+2Fc^2^)/3' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary difmap _refine_ls_shift/su_max 0.008 _refine_ls_shift/su_mean 0.001 _refine_diff_density_max 0.272 _refine_diff_density_min -0.235 _refine_ls_extinction_method none _refine_ls_extinction_coef ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _computing_data_collection ; APEX2 (Bruker, 2014) ; _computing_cell_refinement ; SAINT (Bruker, 2014) ; _computing_data_reduction ; SAINT (Bruker, 2014) ; _computing_structure_solution ; SHELXS2013 (Sheldrick, 2008) ; _computing_structure_refinement ; SHELXL2014 (Sheldrick, 2015) ; _computing_molecular_graphics ; Mercury (Macrae et al., 2006) ; _computing_publication_material ; publCif (Westrip, 2010) and PLATON (Spek, 2009) ; loop_ _atom_site_type_symbol _atom_site_label _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_calc_flag _atom_site_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C C1 0.39192(15) 0.71883(11) 0.80546(10) 0.0182(4) Uani d 1 . . C C2 0.29323(15) 0.76771(11) 0.87419(10) 0.0178(4) Uani d 1 . . H H2 0.2366 0.8123 0.8455 0.021 Uiso calc 1 . . C C3 0.33237(15) 0.81694(11) 0.93856(10) 0.0167(4) Uani d 1 . . H H3 0.4227 0.8146 0.9212 0.02 Uiso calc 1 . . C C4 0.31165(16) 0.77206(11) 1.02534(11) 0.0199(4) Uani d 1 . . H H4 0.2234 0.767 1.0428 0.024 Uiso calc 1 . . C C5 0.34803(17) 0.82311(11) 1.08803(11) 0.0228(4) Uani d 1 . . H H5A 0.4373 0.8225 1.0739 0.027 Uiso calc 1 . . H H5B 0.3297 0.7943 1.1439 0.027 Uiso calc 1 . . C C6 0.27850(17) 0.91845(11) 1.08866(11) 0.0231(4) Uani d 1 . . H H6A 0.1893 0.9196 1.1049 0.028 Uiso calc 1 . . H H6B 0.3035 0.9513 1.1293 0.028 Uiso calc 1 . . C C7 0.30713(16) 0.96120(11) 1.00303(10) 0.0192(4) Uani d 1 . . H H7 0.3973 0.9604 0.9885 0.023 Uiso calc 1 . . C C8 0.27009(15) 0.91625(11) 0.93435(10) 0.0169(4) Uani d 1 . . C C9 0.32337(16) 0.96195(11) 0.85154(10) 0.0196(4) Uani d 1 . . H H9B 0.285 1.0253 0.8542 0.024 Uiso calc 1 . . H H9A 0.4116 0.9585 0.8511 0.024 Uiso calc 1 . . C C10 0.31409(16) 0.93271(11) 0.76616(10) 0.0196(4) Uani d 1 . . H H10 0.2326 0.9153 0.7703 0.024 Uiso calc 1 . . C C11 0.41687(15) 0.85809(11) 0.72360(10) 0.0184(4) Uani d 1 . . H H11 0.4345 0.8795 0.6642 0.022 Uiso calc 1 . . C C12 0.53785(16) 0.85012(11) 0.75254(10) 0.0201(4) Uani d 1 . . C C13 0.58295(16) 0.77927(11) 0.79574(11) 0.0211(4) Uani d 1 . . H H13 0.659 0.7782 0.812 0.025 Uiso calc 1 . . C C14 0.52260(15) 0.70092(11) 0.82067(11) 0.0201(4) Uani d 1 . . H H14A 0.522 0.6854 0.8802 0.024 Uiso calc 1 . . H H14B 0.5706 0.6499 0.7888 0.024 Uiso calc 1 . . C C15 0.38464(15) 0.76528(11) 0.72002(10) 0.0191(4) Uani d 1 . . C C16 0.25946(16) 0.77064(12) 0.69574(11) 0.0225(4) Uani d 1 . . H H16A 0.1941 0.7916 0.7423 0.034 Uiso calc 1 . . H H16B 0.2515 0.712 0.6819 0.034 Uiso calc 1 . . H H16C 0.2529 0.8118 0.6476 0.034 Uiso calc 1 . . C C17 0.47951(17) 0.71477(12) 0.65165(11) 0.0237(4) Uani d 1 . . H H17B 0.4675 0.742 0.5973 0.036 Uiso calc 1 . . H H17C 0.4692 0.6531 0.6547 0.036 Uiso calc 1 . . H H17A 0.5623 0.7171 0.6594 0.036 Uiso calc 1 . . C C18 0.60684(17) 0.92447(12) 0.72667(12) 0.0278(4) Uani d 1 . . H H18A 0.6397 0.9233 0.667 0.042 Uiso calc 1 . . H H18B 0.6745 0.9177 0.7569 0.042 Uiso calc 1 . . H H18C 0.5513 0.9809 0.7392 0.042 Uiso calc 1 . . C C19 0.13055(15) 0.92911(11) 0.94717(11) 0.0214(4) Uani d 1 . . H H19C 0.1076 0.9005 0.9034 0.032 Uiso calc 1 . . H H19A 0.0958 0.9924 0.945 0.032 Uiso calc 1 . . H H19B 0.0988 0.9027 1.0013 0.032 Uiso calc 1 . . O O20 0.22400(11) 0.70057(8) 0.91336(7) 0.0214(3) Uani d 1 . . C C21 0.26240(16) 0.62580(12) 0.87360(11) 0.0216(4) Uani d 1 . . O O22 0.35432(11) 0.63298(7) 0.80929(7) 0.0215(3) Uani d 1 . . O O23 0.22106(12) 0.56013(8) 0.89208(8) 0.0298(3) Uani d 1 . . O O24 0.24272(10) 1.05356(7) 1.00196(7) 0.0201(3) Uani d 1 . . C C25 0.30152(16) 1.11360(11) 1.02153(10) 0.0197(4) Uani d 1 . . O O26 0.39773(11) 1.09511(8) 1.04546(8) 0.0283(3) Uani d 1 . . C C27 0.23598(16) 1.20589(11) 1.01040(10) 0.0194(4) Uani d 1 . . C C28 0.29728(17) 1.27379(12) 1.01677(11) 0.0231(4) Uani d 1 . . H H28 0.3782 1.2602 1.0278 0.028 Uiso calc 1 . . C C29 0.24120(18) 1.36072(12) 1.00719(11) 0.0272(4) Uani d 1 . . H H29 0.2837 1.4068 1.0113 0.033 Uiso calc 1 . . C C30 0.12343(18) 1.38076(12) 0.99168(11) 0.0275(4) Uani d 1 . . H H30 0.0847 1.4407 0.9855 0.033 Uiso calc 1 . . C C31 0.06173(17) 1.31401(12) 0.98513(12) 0.0276(4) Uani d 1 . . H H31 -0.0195 1.3281 0.9748 0.033 Uiso calc 1 . . C C32 0.11788(16) 1.22643(12) 0.99364(11) 0.0226(4) Uani d 1 . . H H32 0.0758 1.1806 0.988 0.027 Uiso calc 1 . . O O33 0.32219(12) 1.00634(8) 0.70805(8) 0.0276(3) Uani d 1 . . H H33 0.2664 1.049 0.7246 0.041 Uiso calc 1 . . O O34 0.38701(11) 0.68492(7) 1.01813(7) 0.0218(3) Uani d 1 . . C C35 0.33439(17) 0.61646(12) 1.06299(11) 0.0248(4) Uani d 1 . . H H35A 0.2477 0.625 1.0568 0.03 Uiso calc 1 . . H H35B 0.3774 0.5597 1.0387 0.03 Uiso calc 1 . . O O36 0.33867(12) 0.61094(8) 1.14683(7) 0.0288(3) Uani d 1 . . C C37 0.4588(2) 0.58010(15) 1.16272(15) 0.0452(6) Uani d 1 . . H H37B 0.5132 0.6193 1.1335 0.068 Uiso calc 1 . . H H37C 0.489 0.5201 1.1432 0.068 Uiso calc 1 . . H H37A 0.457 0.5795 1.2224 0.068 Uiso calc 1 . . C C1' 0.80525(16) 0.74195(11) 0.31038(11) 0.0190(4) Uani d 1 . . C C2' 0.90913(15) 0.67289(11) 0.26359(10) 0.0185(4) Uani d 1 . . H H2' 0.8711 0.6423 0.2274 0.022 Uiso calc 1 . . C C3' 0.98195(15) 0.60049(11) 0.31378(10) 0.0182(4) Uani d 1 . . H H3' 0.9397 0.6052 0.3731 0.022 Uiso calc 1 . . C C4' 1.11310(16) 0.61437(11) 0.30982(11) 0.0225(4) Uani d 1 . . H H4' 1.1551 0.6192 0.2506 0.027 Uiso calc 1 . . C C5' 1.18605(17) 0.53955(12) 0.35504(12) 0.0274(4) Uani d 1 . . H H5'A 1.1505 0.5397 0.415 0.033 Uiso calc 1 . . H H5'B 1.2718 0.5483 0.3478 0.033 Uiso calc 1 . . C C6' 1.18424(17) 0.45122(12) 0.32163(12) 0.0265(4) Uani d 1 . . H H6'A 1.2218 0.4501 0.262 0.032 Uiso calc 1 . . H H6'B 1.2321 0.4028 0.3514 0.032 Uiso calc 1 . . C C7' 1.05332(16) 0.43877(11) 0.33368(11) 0.0216(4) Uani d 1 . . H H7' 1.0172 0.4405 0.3942 0.026 Uiso calc 1 . . C C8' 0.97153(15) 0.50882(11) 0.28678(10) 0.0188(4) Uani d 1 . . C C9' 0.83902(16) 0.49154(11) 0.31629(11) 0.0205(4) Uani d 1 . . H H9'A 0.8245 0.4886 0.3776 0.025 Uiso calc 1 . . H H9'B 0.84 0.4314 0.2995 0.025 Uiso calc 1 . . C C10' 0.72291(15) 0.55088(11) 0.29171(11) 0.0193(4) Uani d 1 . . H H10' 0.7401 0.5667 0.2309 0.023 Uiso calc 1 . . C C11' 0.66133(16) 0.63631(11) 0.33978(10) 0.0189(4) Uani d 1 . . H H11' 0.5715 0.6377 0.3454 0.023 Uiso calc 1 . . C C12' 0.68111(15) 0.62936(11) 0.42879(11) 0.0191(4) Uani d 1 . . C C13' 0.74589(16) 0.68057(11) 0.45440(11) 0.0211(4) Uani d 1 . . H H13' 0.7548 0.6732 0.5108 0.025 Uiso calc 1 . . C C14' 0.80599(16) 0.74896(12) 0.40147(11) 0.0220(4) Uani d 1 . . H H14D 0.8917 0.7418 0.4094 0.026 Uiso calc 1 . . H H14E 0.7625 0.8084 0.4191 0.026 Uiso calc 1 . . C C15' 0.67950(16) 0.72807(11) 0.29790(11) 0.0199(4) Uani d 1 . . C C16' 0.66754(17) 0.73683(12) 0.20653(11) 0.0237(4) Uani d 1 . . H H16D 0.7362 0.6974 0.1743 0.036 Uiso calc 1 . . H H16E 0.6686 0.798 0.1857 0.036 Uiso calc 1 . . H H16F 0.5902 0.7207 0.2012 0.036 Uiso calc 1 . . C C17' 0.57506(16) 0.79806(11) 0.34144(12) 0.0237(4) Uani d 1 . . H H17D 0.5714 0.7911 0.4015 0.036 Uiso calc 1 . . H H17E 0.497 0.7904 0.3288 0.036 Uiso calc 1 . . H H17F 0.5903 0.8572 0.3218 0.036 Uiso calc 1 . . C C18' 0.61846(17) 0.56509(12) 0.48620(11) 0.0264(4) Uani d 1 . . H H18D 0.5294 0.5838 0.4921 0.04 Uiso calc 1 . . H H18E 0.6417 0.5631 0.5406 0.04 Uiso calc 1 . . H H18F 0.6433 0.5063 0.4635 0.04 Uiso calc 1 . . C C19' 1.01302(17) 0.49893(12) 0.19299(11) 0.0237(4) Uani d 1 . . H H19D 1.0253 0.4366 0.1806 0.035 Uiso calc 1 . . H H19E 1.0902 0.5205 0.1742 0.035 Uiso calc 1 . . H H19F 0.9501 0.5335 0.1642 0.035 Uiso calc 1 . . O O20' 0.98878(11) 0.72516(7) 0.20899(7) 0.0218(3) Uani d 1 . . C C21' 0.93856(16) 0.81059(12) 0.21184(11) 0.0219(4) Uani d 1 . . O O22' 0.83303(11) 0.82463(7) 0.26720(7) 0.0230(3) Uani d 1 . . O O23' 0.98135(12) 0.86793(8) 0.17053(8) 0.0291(3) Uani d 1 . . O O24' 1.05092(11) 0.35259(7) 0.30544(7) 0.0232(3) Uani d 1 . . C C25' 1.05285(16) 0.28473(12) 0.36162(11) 0.0230(4) Uani d 1 . . O O26' 1.05309(14) 0.29155(9) 0.43359(8) 0.0366(4) Uani d 1 . . C C27' 1.05285(16) 0.20029(11) 0.32452(11) 0.0226(4) Uani d 1 . . C C28' 1.03407(19) 0.12820(13) 0.37777(13) 0.0328(5) Uani d 1 . . H H28' 1.0236 0.1332 0.4359 0.039 Uiso calc 1 . . C C29' 1.0305(2) 0.04866(13) 0.34638(14) 0.0403(5) Uani d 1 . . H H29' 1.0167 -0.0006 0.3831 0.048 Uiso calc 1 . . C C30' 1.04693(18) 0.04084(13) 0.26221(13) 0.0343(5) Uani d 1 . . H H30' 1.044 -0.0137 0.2409 0.041 Uiso calc 1 . . C C31' 1.06757(16) 0.11189(12) 0.20896(12) 0.0270(4) Uani d 1 . . H H31' 1.0804 0.1059 0.1508 0.032 Uiso calc 1 . . C C32' 1.06975(15) 0.19203(12) 0.23947(11) 0.0231(4) Uani d 1 . . H H32' 1.0828 0.2412 0.2024 0.028 Uiso calc 1 . . O O33' 0.62847(11) 0.49828(8) 0.30885(8) 0.0254(3) Uani d 1 . . H H33' 0.6435 0.4595 0.2736 0.038 Uiso calc 1 . . O O34' 1.09963(11) 0.69699(8) 0.34778(8) 0.0255(3) Uani d 1 . . C C35' 1.1978(2) 0.74151(14) 0.32338(13) 0.0370(5) Uani d 1 . . H H35D 1.2264 0.7375 0.2628 0.044 Uiso calc 1 . . H H35F 1.1685 0.8047 0.335 0.044 Uiso calc 1 . . O O36' 1.29654(12) 0.70912(10) 0.36255(10) 0.0446(4) Uani d 1 . . C C37' 1.2687(2) 0.72296(17) 0.44817(15) 0.0529(7) Uani d 1 . . H H37D 1.3415 0.6998 0.4725 0.079 Uiso calc 1 . . H H37E 1.2021 0.6923 0.4747 0.079 Uiso calc 1 . . H H37F 1.2432 0.7864 0.4569 0.079 Uiso calc 1 . . C C1P 0.2437(5) 0.9991(4) 0.5096(4) 0.0466(14) Uani d 0.5 A -1 H H1PA 0.2192 1.0095 0.569 0.07 Uiso calc 0.5 A -1 H H1PB 0.1943 0.9599 0.4945 0.07 Uiso calc 0.5 A -1 H H1PC 0.2307 1.0555 0.4777 0.07 Uiso calc 0.5 A -1 C C2P 0.3778(6) 0.9566(6) 0.4905(6) 0.0345(17) Uani d 0.5 A -1 H H2PA 0.4002 0.942 0.4314 0.041 Uiso calc 0.5 A -1 H H2PB 0.3906 0.9007 0.5242 0.041 Uiso calc 0.5 A -1 C C3P 0.4624(5) 1.0156(5) 0.5077(5) 0.036(3) Uani d 0.5 A -1 H H3PA 0.4536 1.0696 0.471 0.043 Uiso calc 0.5 A -1 H H3PB 0.4357 1.0338 0.5656 0.043 Uiso calc 0.5 A -1 C C4P 0.5962(7) 0.9719(8) 0.4947(7) 0.044(2) Uani d 0.5 A -1 H H4PA 0.6228 0.9528 0.437 0.053 Uiso calc 0.5 A -1 H H4PB 0.6055 0.9184 0.5322 0.053 Uiso calc 0.5 A -1 C C5P 0.6788(7) 1.0321(6) 0.5108(6) 0.047(2) Uani d 0.5 A -1 H H5PA 0.6741 1.0834 0.4715 0.07 Uiso calc 0.5 A -1 H H5PB 0.7636 0.9998 0.5038 0.07 Uiso calc 0.5 A -1 H H5PC 0.6521 1.0522 0.5675 0.07 Uiso calc 0.5 A -1 loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_12 _atom_site_aniso_U_13 _atom_site_aniso_U_23 C1 0.0196(9) 0.0124(9) 0.0231(9) -0.0029(7) -0.0042(7) -0.0035(7) C2 0.0196(9) 0.0145(9) 0.0193(9) -0.0040(7) -0.0026(7) -0.0005(7) C3 0.0138(9) 0.0148(9) 0.0206(9) -0.0020(7) -0.0009(7) -0.0039(7) C4 0.0203(10) 0.0151(9) 0.0226(10) -0.0024(7) -0.0008(8) -0.0021(7) C5 0.0287(11) 0.0216(10) 0.0192(9) -0.0069(8) -0.0045(8) -0.0011(8) C6 0.0247(10) 0.0228(10) 0.0223(10) -0.0053(8) -0.0021(8) -0.0077(8) C7 0.0174(9) 0.0146(9) 0.0248(10) -0.0008(7) -0.0030(8) -0.0042(7) C8 0.0149(9) 0.0166(9) 0.0186(9) -0.0031(7) -0.0010(7) -0.0029(7) C9 0.0190(9) 0.0154(9) 0.0241(10) -0.0014(7) -0.0038(8) -0.0037(7) C10 0.0195(9) 0.0159(9) 0.0219(9) -0.0012(7) -0.0034(7) 0.0019(7) C11 0.0189(9) 0.0188(9) 0.0163(9) -0.0027(7) -0.0013(7) -0.0010(7) C12 0.0188(9) 0.0220(10) 0.0183(9) -0.0031(7) 0.0001(7) -0.0049(8) C13 0.0153(9) 0.0255(10) 0.0219(9) -0.0019(7) -0.0030(7) -0.0048(8) C14 0.0200(10) 0.0172(9) 0.0211(9) 0.0022(7) -0.0035(8) -0.0035(7) C15 0.0185(9) 0.0194(9) 0.0188(9) -0.0027(7) -0.0025(7) -0.0033(7) C16 0.0255(10) 0.0225(10) 0.0209(9) -0.0042(8) -0.0070(8) -0.0026(8) C17 0.0263(10) 0.0220(10) 0.0220(10) -0.0020(8) -0.0038(8) -0.0044(8) C18 0.0232(10) 0.0267(11) 0.0327(11) -0.0050(8) -0.0034(8) -0.0006(9) C19 0.0178(9) 0.0188(9) 0.0269(10) -0.0013(7) -0.0025(8) -0.0071(8) O20 0.0205(7) 0.0192(7) 0.0249(7) -0.0077(5) 0.0003(5) -0.0052(5) C21 0.0230(10) 0.0206(10) 0.0225(10) -0.0041(8) -0.0071(8) -0.0023(8) O22 0.0245(7) 0.0153(6) 0.0241(7) -0.0046(5) -0.0015(6) -0.0038(5) O23 0.0360(8) 0.0211(7) 0.0353(8) -0.0141(6) -0.0050(6) -0.0013(6) O24 0.0193(6) 0.0147(6) 0.0271(7) -0.0027(5) -0.0042(5) -0.0065(5) C25 0.0187(10) 0.0205(10) 0.0204(9) -0.0044(8) -0.0021(8) -0.0051(7) O26 0.0252(8) 0.0221(7) 0.0403(8) -0.0016(6) -0.0127(6) -0.0069(6) C27 0.0233(10) 0.0180(9) 0.0158(9) -0.0026(7) -0.0012(7) -0.0033(7) C28 0.0240(10) 0.0229(10) 0.0236(10) -0.0040(8) -0.0059(8) -0.0054(8) C29 0.0372(12) 0.0194(10) 0.0271(10) -0.0077(8) -0.0070(9) -0.0044(8) C30 0.0347(12) 0.0173(10) 0.0254(10) 0.0029(8) -0.0011(9) -0.0009(8) C31 0.0184(10) 0.0287(11) 0.0314(11) 0.0018(8) -0.0019(8) 0.0013(9) C32 0.0212(10) 0.0233(10) 0.0233(10) -0.0071(8) -0.0011(8) -0.0018(8) O33 0.0342(8) 0.0182(7) 0.0259(7) 0.0014(6) -0.0026(6) 0.0019(6) O34 0.0255(7) 0.0151(6) 0.0237(7) -0.0036(5) -0.0030(5) 0.0006(5) C35 0.0298(11) 0.0187(10) 0.0274(10) -0.0073(8) -0.0076(8) 0.0029(8) O36 0.0321(8) 0.0298(7) 0.0229(7) -0.0051(6) -0.0048(6) 0.0051(6) C37 0.0452(14) 0.0441(14) 0.0534(15) -0.0124(11) -0.0287(12) 0.0146(11) C1' 0.0211(10) 0.0112(9) 0.0243(10) -0.0038(7) -0.0033(8) 0.0000(7) C2' 0.0175(9) 0.0180(9) 0.0209(9) -0.0068(7) -0.0034(7) 0.0008(7) C3' 0.0185(9) 0.0171(9) 0.0181(9) -0.0020(7) -0.0031(7) -0.0003(7) C4' 0.0204(10) 0.0221(10) 0.0261(10) -0.0044(8) -0.0056(8) -0.0031(8) C5' 0.0193(10) 0.0299(11) 0.0341(11) -0.0042(8) -0.0097(8) 0.0017(9) C6' 0.0237(10) 0.0219(10) 0.0318(11) 0.0030(8) -0.0085(8) 0.0011(8) C7' 0.0242(10) 0.0176(9) 0.0224(10) -0.0009(7) -0.0048(8) -0.0031(7) C8' 0.0189(9) 0.0175(9) 0.0199(9) -0.0019(7) -0.0043(7) -0.0022(7) C9' 0.0240(10) 0.0144(9) 0.0238(10) -0.0033(7) -0.0053(8) -0.0034(7) C10' 0.0207(10) 0.0168(9) 0.0221(9) -0.0063(7) -0.0045(8) -0.0030(7) C11' 0.0170(9) 0.0172(9) 0.0231(9) -0.0039(7) -0.0032(7) -0.0038(7) C12' 0.0179(9) 0.0163(9) 0.0214(9) -0.0003(7) -0.0010(7) -0.0039(7) C13' 0.0213(10) 0.0232(10) 0.0181(9) -0.0021(8) -0.0031(8) -0.0043(8) C14' 0.0216(10) 0.0195(10) 0.0260(10) -0.0042(7) -0.0041(8) -0.0067(8) C15' 0.0202(10) 0.0153(9) 0.0245(10) -0.0023(7) -0.0047(8) -0.0042(7) C16' 0.0235(10) 0.0203(10) 0.0271(10) -0.0014(8) -0.0074(8) 0.0002(8) C17' 0.0211(10) 0.0181(10) 0.0319(11) -0.0022(7) -0.0052(8) -0.0039(8) C18' 0.0265(11) 0.0252(10) 0.0263(10) -0.0050(8) -0.0014(8) -0.0033(8) C19' 0.0258(10) 0.0194(10) 0.0243(10) -0.0001(8) -0.0046(8) -0.0029(8) O20' 0.0205(7) 0.0184(7) 0.0248(7) -0.0039(5) -0.0021(5) 0.0033(5) C21' 0.0204(10) 0.0216(10) 0.0260(10) -0.0064(8) -0.0079(8) 0.0007(8) O22' 0.0226(7) 0.0148(6) 0.0303(7) -0.0043(5) -0.0021(6) 0.0009(5) O23' 0.0298(8) 0.0242(7) 0.0345(8) -0.0115(6) -0.0059(6) 0.0067(6) O24' 0.0294(7) 0.0154(6) 0.0235(7) 0.0007(5) -0.0069(5) -0.0016(5) C25' 0.0204(10) 0.0235(10) 0.0255(11) -0.0023(8) -0.0077(8) 0.0011(8) O26' 0.0626(10) 0.0264(8) 0.0268(8) -0.0135(7) -0.0178(7) 0.0013(6) C27' 0.0184(10) 0.0195(10) 0.0301(11) -0.0006(7) -0.0075(8) -0.0021(8) C28' 0.0420(13) 0.0270(11) 0.0291(11) -0.0067(9) -0.0059(9) -0.0012(9) C29' 0.0523(14) 0.0217(11) 0.0457(14) -0.0112(10) -0.0027(11) 0.0000(10) C30' 0.0337(12) 0.0260(11) 0.0440(13) -0.0073(9) -0.0034(10) -0.0121(10) C31' 0.0191(10) 0.0304(11) 0.0315(11) -0.0022(8) -0.0030(8) -0.0115(9) C32' 0.0141(9) 0.0242(10) 0.0305(11) -0.0008(7) -0.0048(8) -0.0029(8) O33' 0.0259(7) 0.0194(7) 0.0340(8) -0.0078(5) -0.0057(6) -0.0095(6) O34' 0.0230(7) 0.0230(7) 0.0334(7) -0.0082(5) -0.0084(6) -0.0017(6) C35' 0.0419(13) 0.0394(13) 0.0365(12) -0.0245(10) -0.0065(10) -0.0009(10) O36' 0.0221(8) 0.0521(10) 0.0644(11) -0.0103(7) -0.0081(7) -0.0220(8) C37' 0.0500(15) 0.0592(16) 0.0602(17) -0.0112(12) -0.0312(13) -0.0112(13) C1P 0.040(3) 0.054(4) 0.045(3) -0.006(3) -0.007(3) -0.007(3) C2P 0.047(5) 0.029(3) 0.026(3) -0.002(4) -0.006(4) -0.005(2) C3P 0.057(9) 0.022(5) 0.021(3) 0.000(6) 0.008(6) -0.008(3) C4P 0.054(7) 0.042(4) 0.031(3) -0.003(5) 0.002(4) -0.004(3) C5P 0.047(6) 0.051(5) 0.040(3) -0.011(5) -0.003(5) 0.008(3) _geom_special_details ; All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_site_symmetry_2 _geom_bond_distance _geom_bond_publ_flag C1 O22 . 1.466(2) ? C1 C14 . 1.519(2) ? C1 C15 . 1.536(2) ? C1 C2 . 1.551(2) ? C2 O20 . 1.455(2) ? C2 C3 . 1.538(2) ? C2 H2 . 1.0 ? C3 C4 . 1.531(2) ? C3 C8 . 1.560(2) ? C3 H3 . 1.0 ? C4 O34 . 1.445(2) ? C4 C5 . 1.517(2) ? C4 H4 . 1.0 ? C5 C6 . 1.527(2) ? C5 H5A . 0.99 ? C5 H5B . 0.99 ? C6 C7 . 1.509(2) ? C6 H6A . 0.99 ? C6 H6B . 0.99 ? C7 O24 . 1.470(2) ? C7 C8 . 1.544(2) ? C7 H7 . 1.0 ? C8 C19 . 1.527(2) ? C8 C9 . 1.550(2) ? C9 C10 . 1.544(2) ? C9 H9B . 0.99 ? C9 H9A . 0.99 ? C10 O33 . 1.429(2) ? C10 C11 . 1.567(2) ? C10 H10 . 1.0 ? C11 C12 . 1.520(2) ? C11 C15 . 1.559(2) ? C11 H11 . 1.0 ? C12 C13 . 1.327(2) ? C12 C18 . 1.502(2) ? C13 C14 . 1.496(2) ? C13 H13 . 0.95 ? C14 H14A . 0.99 ? C14 H14B . 0.99 ? C15 C16 . 1.535(2) ? C15 C17 . 1.538(2) ? C16 H16A . 0.98 ? C16 H16B . 0.98 ? C16 H16C . 0.98 ? C17 H17B . 0.98 ? C17 H17C . 0.98 ? C17 H17A . 0.98 ? C18 H18A . 0.98 ? C18 H18B . 0.98 ? C18 H18C . 0.98 ? C19 H19C . 0.98 ? C19 H19A . 0.98 ? C19 H19B . 0.98 ? O20 C21 . 1.330(2) ? C21 O23 . 1.193(2) ? C21 O22 . 1.343(2) ? O24 C25 . 1.340(2) ? C25 O26 . 1.207(2) ? C25 C27 . 1.487(2) ? C27 C32 . 1.391(2) ? C27 C28 . 1.391(2) ? C28 C29 . 1.379(3) ? C28 H28 . 0.95 ? C29 C30 . 1.379(3) ? C29 H29 . 0.95 ? C30 C31 . 1.380(3) ? C30 H30 . 0.95 ? C31 C32 . 1.386(3) ? C31 H31 . 0.95 ? C32 H32 . 0.95 ? O33 H33 . 0.84 ? O34 C35 . 1.401(2) ? C35 O36 . 1.388(2) ? C35 H35A . 0.99 ? C35 H35B . 0.99 ? O36 C37 . 1.419(2) ? C37 H37B . 0.98 ? C37 H37C . 0.98 ? C37 H37A . 0.98 ? C1' O22' . 1.468(2) ? C1' C14' . 1.517(2) ? C1' C15' . 1.539(2) ? C1' C2' . 1.548(2) ? C2' O20' . 1.455(2) ? C2' C3' . 1.539(2) ? C2' H2' . 1.0 ? C3' C4' . 1.531(2) ? C3' C8' . 1.555(2) ? C3' H3' . 1.0 ? C4' O34' . 1.438(2) ? C4' C5' . 1.516(2) ? C4' H4' . 1.0 ? C5' C6' . 1.521(3) ? C5' H5'A . 0.99 ? C5' H5'B . 0.99 ? C6' C7' . 1.506(3) ? C6' H6'A . 0.99 ? C6' H6'B . 0.99 ? C7' O24' . 1.456(2) ? C7' C8' . 1.542(2) ? C7' H7' . 1.0 ? C8' C19' . 1.534(2) ? C8' C9' . 1.552(2) ? C9' C10' . 1.552(2) ? C9' H9'A . 0.99 ? C9' H9'B . 0.99 ? C10' O33' . 1.440(2) ? C10' C11' . 1.565(2) ? C10' H10' . 1.0 ? C11' C12' . 1.520(2) ? C11' C15' . 1.557(2) ? C11' H11' . 1.0 ? C12' C13' . 1.326(2) ? C12' C18' . 1.496(2) ? C13' C14' . 1.495(2) ? C13' H13' . 0.95 ? C14' H14D . 0.99 ? C14' H14E . 0.99 ? C15' C16' . 1.532(2) ? C15' C17' . 1.539(2) ? C16' H16D . 0.98 ? C16' H16E . 0.98 ? C16' H16F . 0.98 ? C17' H17D . 0.98 ? C17' H17E . 0.98 ? C17' H17F . 0.98 ? C18' H18D . 0.98 ? C18' H18E . 0.98 ? C18' H18F . 0.98 ? C19' H19D . 0.98 ? C19' H19E . 0.98 ? C19' H19F . 0.98 ? O20' C21' . 1.331(2) ? C21' O23' . 1.192(2) ? C21' O22' . 1.342(2) ? O24' C25' . 1.339(2) ? C25' O26' . 1.201(2) ? C25' C27' . 1.489(3) ? C27' C28' . 1.383(3) ? C27' C32' . 1.390(3) ? C28' C29' . 1.385(3) ? C28' H28' . 0.95 ? C29' C30' . 1.375(3) ? C29' H29' . 0.95 ? C30' C31' . 1.374(3) ? C30' H30' . 0.95 ? C31' C32' . 1.383(3) ? C31' H31' . 0.95 ? C32' H32' . 0.95 ? O33' H33' . 0.84 ? O34' C35' . 1.397(2) ? C35' O36' . 1.390(3) ? C35' H35D . 0.99 ? C35' H35F . 0.99 ? O36' C37' . 1.408(3) ? C37' H37D . 0.98 ? C37' H37E . 0.98 ? C37' H37F . 0.98 ? C1P C2P . 1.512(7) ? C1P H1PA . 0.98 ? C1P H1PB . 0.98 ? C1P H1PC . 0.98 ? C2P C3P . 1.527(12) ? C2P H2PA . 0.99 ? C2P H2PB . 0.99 ? C3P C4P . 1.513(9) ? C3P H3PA . 0.99 ? C3P H3PB . 0.99 ? C4P C5P . 1.519(13) ? C4P H4PA . 0.99 ? C4P H4PB . 0.99 ? C5P H5PA . 0.98 ? C5P H5PB . 0.98 ? C5P H5PC . 0.98 ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle _geom_angle_publ_flag O22 C1 C14 . . 106.92(13) ? O22 C1 C15 . . 109.83(13) ? C14 C1 C15 . . 110.95(14) ? O22 C1 C2 . . 101.66(13) ? C14 C1 C2 . . 115.83(14) ? C15 C1 C2 . . 111.06(13) ? O20 C2 C3 . . 111.66(13) ? O20 C2 C1 . . 104.22(12) ? C3 C2 C1 . . 119.74(14) ? O20 C2 H2 . . 106.8 ? C3 C2 H2 . . 106.8 ? C1 C2 H2 . . 106.8 ? C4 C3 C2 . . 112.38(14) ? C4 C3 C8 . . 114.30(13) ? C2 C3 C8 . . 109.19(13) ? C4 C3 H3 . . 106.8 ? C2 C3 H3 . . 106.8 ? C8 C3 H3 . . 106.8 ? O34 C4 C5 . . 110.55(14) ? O34 C4 C3 . . 105.85(13) ? C5 C4 C3 . . 111.33(14) ? O34 C4 H4 . . 109.7 ? C5 C4 H4 . . 109.7 ? C3 C4 H4 . . 109.7 ? C4 C5 C6 . . 110.58(14) ? C4 C5 H5A . . 109.5 ? C6 C5 H5A . . 109.5 ? C4 C5 H5B . . 109.5 ? C6 C5 H5B . . 109.5 ? H5A C5 H5B . . 108.1 ? C7 C6 C5 . . 108.84(14) ? C7 C6 H6A . . 109.9 ? C5 C6 H6A . . 109.9 ? C7 C6 H6B . . 109.9 ? C5 C6 H6B . . 109.9 ? H6A C6 H6B . . 108.3 ? O24 C7 C6 . . 110.10(13) ? O24 C7 C8 . . 106.75(13) ? C6 C7 C8 . . 114.54(14) ? O24 C7 H7 . . 108.4 ? C6 C7 H7 . . 108.4 ? C8 C7 H7 . . 108.4 ? C19 C8 C7 . . 109.82(14) ? C19 C8 C9 . . 111.08(14) ? C7 C8 C9 . . 105.73(13) ? C19 C8 C3 . . 112.58(14) ? C7 C8 C3 . . 106.92(13) ? C9 C8 C3 . . 110.40(13) ? C10 C9 C8 . . 122.76(14) ? C10 C9 H9B . . 106.6 ? C8 C9 H9B . . 106.6 ? C10 C9 H9A . . 106.6 ? C8 C9 H9A . . 106.6 ? H9B C9 H9A . . 106.6 ? O33 C10 C9 . . 108.12(14) ? O33 C10 C11 . . 103.00(13) ? C9 C10 C11 . . 118.56(14) ? O33 C10 H10 . . 108.9 ? C9 C10 H10 . . 108.9 ? C11 C10 H10 . . 108.9 ? C12 C11 C15 . . 110.87(14) ? C12 C11 C10 . . 113.25(14) ? C15 C11 C10 . . 118.18(14) ? C12 C11 H11 . . 104.3 ? C15 C11 H11 . . 104.3 ? C10 C11 H11 . . 104.3 ? C13 C12 C18 . . 121.45(16) ? C13 C12 C11 . . 121.67(16) ? C18 C12 C11 . . 116.82(15) ? C12 C13 C14 . . 124.68(16) ? C12 C13 H13 . . 117.7 ? C14 C13 H13 . . 117.7 ? C13 C14 C1 . . 111.73(14) ? C13 C14 H14A . . 109.3 ? C1 C14 H14A . . 109.3 ? C13 C14 H14B . . 109.3 ? C1 C14 H14B . . 109.3 ? H14A C14 H14B . . 107.9 ? C16 C15 C1 . . 112.74(14) ? C16 C15 C17 . . 105.90(14) ? C1 C15 C17 . . 110.91(14) ? C16 C15 C11 . . 112.53(14) ? C1 C15 C11 . . 106.34(13) ? C17 C15 C11 . . 108.40(14) ? C15 C16 H16A . . 109.5 ? C15 C16 H16B . . 109.5 ? H16A C16 H16B . . 109.5 ? C15 C16 H16C . . 109.5 ? H16A C16 H16C . . 109.5 ? H16B C16 H16C . . 109.5 ? C15 C17 H17B . . 109.5 ? C15 C17 H17C . . 109.5 ? H17B C17 H17C . . 109.5 ? C15 C17 H17A . . 109.5 ? H17B C17 H17A . . 109.5 ? H17C C17 H17A . . 109.5 ? C12 C18 H18A . . 109.5 ? C12 C18 H18B . . 109.5 ? H18A C18 H18B . . 109.5 ? C12 C18 H18C . . 109.5 ? H18A C18 H18C . . 109.5 ? H18B C18 H18C . . 109.5 ? C8 C19 H19C . . 109.5 ? C8 C19 H19A . . 109.5 ? H19C C19 H19A . . 109.5 ? C8 C19 H19B . . 109.5 ? H19C C19 H19B . . 109.5 ? H19A C19 H19B . . 109.5 ? C21 O20 C2 . . 110.60(13) ? O23 C21 O20 . . 124.81(17) ? O23 C21 O22 . . 123.59(16) ? O20 C21 O22 . . 111.60(15) ? C21 O22 C1 . . 111.40(13) ? C25 O24 C7 . . 116.45(13) ? O26 C25 O24 . . 123.80(16) ? O26 C25 C27 . . 123.31(16) ? O24 C25 C27 . . 112.90(15) ? C32 C27 C28 . . 119.41(16) ? C32 C27 C25 . . 122.92(16) ? C28 C27 C25 . . 117.67(16) ? C29 C28 C27 . . 120.35(17) ? C29 C28 H28 . . 119.8 ? C27 C28 H28 . . 119.8 ? C28 C29 C30 . . 120.01(18) ? C28 C29 H29 . . 120.0 ? C30 C29 H29 . . 120.0 ? C29 C30 C31 . . 120.18(17) ? C29 C30 H30 . . 119.9 ? C31 C30 H30 . . 119.9 ? C30 C31 C32 . . 120.23(17) ? C30 C31 H31 . . 119.9 ? C32 C31 H31 . . 119.9 ? C31 C32 C27 . . 119.80(17) ? C31 C32 H32 . . 120.1 ? C27 C32 H32 . . 120.1 ? C10 O33 H33 . . 109.5 ? C35 O34 C4 . . 115.66(13) ? O36 C35 O34 . . 114.13(14) ? O36 C35 H35A . . 108.7 ? O34 C35 H35A . . 108.7 ? O36 C35 H35B . . 108.7 ? O34 C35 H35B . . 108.7 ? H35A C35 H35B . . 107.6 ? C35 O36 C37 . . 112.85(15) ? O36 C37 H37B . . 109.5 ? O36 C37 H37C . . 109.5 ? H37B C37 H37C . . 109.5 ? O36 C37 H37A . . 109.5 ? H37B C37 H37A . . 109.5 ? H37C C37 H37A . . 109.5 ? O22' C1' C14' . . 107.45(13) ? O22' C1' C15' . . 109.95(13) ? C14' C1' C15' . . 111.00(14) ? O22' C1' C2' . . 101.43(13) ? C14' C1' C2' . . 116.01(14) ? C15' C1' C2' . . 110.45(13) ? O20' C2' C3' . . 111.74(13) ? O20' C2' C1' . . 104.56(13) ? C3' C2' C1' . . 119.08(14) ? O20' C2' H2' . . 106.9 ? C3' C2' H2' . . 106.9 ? C1' C2' H2' . . 106.9 ? C4' C3' C2' . . 112.31(14) ? C4' C3' C8' . . 115.02(14) ? C2' C3' C8' . . 108.62(13) ? C4' C3' H3' . . 106.8 ? C2' C3' H3' . . 106.8 ? C8' C3' H3' . . 106.8 ? O34' C4' C5' . . 111.30(14) ? O34' C4' C3' . . 105.04(13) ? C5' C4' C3' . . 111.67(15) ? O34' C4' H4' . . 109.6 ? C5' C4' H4' . . 109.6 ? C3' C4' H4' . . 109.6 ? C4' C5' C6' . . 110.44(15) ? C4' C5' H5'A . . 109.6 ? C6' C5' H5'A . . 109.6 ? C4' C5' H5'B . . 109.6 ? C6' C5' H5'B . . 109.6 ? H5'A C5' H5'B . . 108.1 ? C7' C6' C5' . . 108.79(15) ? C7' C6' H6'A . . 109.9 ? C5' C6' H6'A . . 109.9 ? C7' C6' H6'B . . 109.9 ? C5' C6' H6'B . . 109.9 ? H6'A C6' H6'B . . 108.3 ? O24' C7' C6' . . 109.24(14) ? O24' C7' C8' . . 107.71(13) ? C6' C7' C8' . . 114.27(15) ? O24' C7' H7' . . 108.5 ? C6' C7' H7' . . 108.5 ? C8' C7' H7' . . 108.5 ? C19' C8' C7' . . 109.93(14) ? C19' C8' C9' . . 111.03(14) ? C7' C8' C9' . . 105.96(14) ? C19' C8' C3' . . 112.37(14) ? C7' C8' C3' . . 106.79(13) ? C9' C8' C3' . . 110.48(14) ? C8' C9' C10' . . 124.69(14) ? C8' C9' H9'A . . 106.2 ? C10' C9' H9'A . . 106.2 ? C8' C9' H9'B . . 106.2 ? C10' C9' H9'B . . 106.2 ? H9'A C9' H9'B . . 106.3 ? O33' C10' C9' . . 106.31(13) ? O33' C10' C11' . . 102.98(13) ? C9' C10' C11' . . 119.59(14) ? O33' C10' H10' . . 109.1 ? C9' C10' H10' . . 109.1 ? C11' C10' H10' . . 109.1 ? C12' C11' C15' . . 110.97(14) ? C12' C11' C10' . . 112.90(14) ? C15' C11' C10' . . 119.20(14) ? C12' C11' H11' . . 104.0 ? C15' C11' H11' . . 104.0 ? C10' C11' H11' . . 104.0 ? C13' C12' C18' . . 122.25(16) ? C13' C12' C11' . . 121.39(16) ? C18' C12' C11' . . 116.29(15) ? C12' C13' C14' . . 125.10(16) ? C12' C13' H13' . . 117.4 ? C14' C13' H13' . . 117.4 ? C13' C14' C1' . . 111.79(14) ? C13' C14' H14D . . 109.3 ? C1' C14' H14D . . 109.3 ? C13' C14' H14E . . 109.3 ? C1' C14' H14E . . 109.3 ? H14D C14' H14E . . 107.9 ? C16' C15' C1' . . 112.57(14) ? C16' C15' C17' . . 105.41(14) ? C1' C15' C17' . . 111.34(14) ? C16' C15' C11' . . 113.16(14) ? C1' C15' C11' . . 106.73(13) ? C17' C15' C11' . . 107.59(14) ? C15' C16' H16D . . 109.5 ? C15' C16' H16E . . 109.5 ? H16D C16' H16E . . 109.5 ? C15' C16' H16F . . 109.5 ? H16D C16' H16F . . 109.5 ? H16E C16' H16F . . 109.5 ? C15' C17' H17D . . 109.5 ? C15' C17' H17E . . 109.5 ? H17D C17' H17E . . 109.5 ? C15' C17' H17F . . 109.5 ? H17D C17' H17F . . 109.5 ? H17E C17' H17F . . 109.5 ? C12' C18' H18D . . 109.5 ? C12' C18' H18E . . 109.5 ? H18D C18' H18E . . 109.5 ? C12' C18' H18F . . 109.5 ? H18D C18' H18F . . 109.5 ? H18E C18' H18F . . 109.5 ? C8' C19' H19D . . 109.5 ? C8' C19' H19E . . 109.5 ? H19D C19' H19E . . 109.5 ? C8' C19' H19F . . 109.5 ? H19D C19' H19F . . 109.5 ? H19E C19' H19F . . 109.5 ? C21' O20' C2' . . 110.28(13) ? O23' C21' O20' . . 124.57(17) ? O23' C21' O22' . . 123.78(16) ? O20' C21' O22' . . 111.64(15) ? C21' O22' C1' . . 111.54(13) ? C25' O24' C7' . . 117.38(13) ? O26' C25' O24' . . 123.87(17) ? O26' C25' C27' . . 124.10(17) ? O24' C25' C27' . . 112.03(15) ? C28' C27' C32' . . 119.59(17) ? C28' C27' C25' . . 117.84(17) ? C32' C27' C25' . . 122.57(16) ? C27' C28' C29' . . 120.05(19) ? C27' C28' H28' . . 120.0 ? C29' C28' H28' . . 120.0 ? C30' C29' C28' . . 120.18(19) ? C30' C29' H29' . . 119.9 ? C28' C29' H29' . . 119.9 ? C31' C30' C29' . . 120.00(19) ? C31' C30' H30' . . 120.0 ? C29' C30' H30' . . 120.0 ? C30' C31' C32' . . 120.44(18) ? C30' C31' H31' . . 119.8 ? C32' C31' H31' . . 119.8 ? C31' C32' C27' . . 119.73(17) ? C31' C32' H32' . . 120.1 ? C27' C32' H32' . . 120.1 ? C10' O33' H33' . . 109.5 ? C35' O34' C4' . . 115.53(14) ? O36' C35' O34' . . 114.07(17) ? O36' C35' H35D . . 108.7 ? O34' C35' H35D . . 108.7 ? O36' C35' H35F . . 108.7 ? O34' C35' H35F . . 108.7 ? H35D C35' H35F . . 107.6 ? C35' O36' C37' . . 112.82(17) ? O36' C37' H37D . . 109.5 ? O36' C37' H37E . . 109.5 ? H37D C37' H37E . . 109.5 ? O36' C37' H37F . . 109.5 ? H37D C37' H37F . . 109.5 ? H37E C37' H37F . . 109.5 ? C2P C1P H1PA . . 109.5 ? C2P C1P H1PB . . 109.5 ? H1PA C1P H1PB . . 109.5 ? C2P C1P H1PC . . 109.5 ? H1PA C1P H1PC . . 109.5 ? H1PB C1P H1PC . . 109.5 ? C1P C2P C3P . . 113.0(6) ? C1P C2P H2PA . . 109.0 ? C3P C2P H2PA . . 109.0 ? C1P C2P H2PB . . 109.0 ? C3P C2P H2PB . . 109.0 ? H2PA C2P H2PB . . 107.8 ? C4P C3P C2P . . 113.9(5) ? C4P C3P H3PA . . 108.8 ? C2P C3P H3PA . . 108.8 ? C4P C3P H3PB . . 108.8 ? C2P C3P H3PB . . 108.8 ? H3PA C3P H3PB . . 107.7 ? C3P C4P C5P . . 113.0(6) ? C3P C4P H4PA . . 109.0 ? C5P C4P H4PA . . 109.0 ? C3P C4P H4PB . . 109.0 ? C5P C4P H4PB . . 109.0 ? H4PA C4P H4PB . . 107.8 ? C4P C5P H5PA . . 109.5 ? C4P C5P H5PB . . 109.5 ? H5PA C5P H5PB . . 109.5 ? C4P C5P H5PC . . 109.5 ? H5PA C5P H5PC . . 109.5 ? H5PB C5P H5PC . . 109.5 ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion _geom_torsion_publ_flag O22 C1 C2 O20 . . . . 6.62(15) ? C14 C1 C2 O20 . . . . -108.85(15) ? C15 C1 C2 O20 . . . . 123.41(14) ? O22 C1 C2 C3 . . . . 132.30(14) ? C14 C1 C2 C3 . . . . 16.8(2) ? C15 C1 C2 C3 . . . . -110.91(17) ? O20 C2 C3 C4 . . . . 11.23(19) ? C1 C2 C3 C4 . . . . -110.86(16) ? O20 C2 C3 C8 . . . . -116.69(14) ? C1 C2 C3 C8 . . . . 121.21(16) ? C2 C3 C4 O34 . . . . 61.23(17) ? C8 C3 C4 O34 . . . . -173.60(13) ? C2 C3 C4 C5 . . . . -178.60(14) ? C8 C3 C4 C5 . . . . -53.42(19) ? O34 C4 C5 C6 . . . . 173.67(14) ? C3 C4 C5 C6 . . . . 56.31(19) ? C4 C5 C6 C7 . . . . -59.01(19) ? C5 C6 C7 O24 . . . . -179.24(13) ? C5 C6 C7 C8 . . . . 60.47(19) ? O24 C7 C8 C19 . . . . -54.43(17) ? C6 C7 C8 C19 . . . . 67.71(18) ? O24 C7 C8 C9 . . . . 65.48(16) ? C6 C7 C8 C9 . . . . -172.38(14) ? O24 C7 C8 C3 . . . . -176.86(13) ? C6 C7 C8 C3 . . . . -54.72(18) ? C4 C3 C8 C19 . . . . -70.39(18) ? C2 C3 C8 C19 . . . . 56.45(18) ? C4 C3 C8 C7 . . . . 50.29(18) ? C2 C3 C8 C7 . . . . 177.14(13) ? C4 C3 C8 C9 . . . . 164.85(14) ? C2 C3 C8 C9 . . . . -68.31(17) ? C19 C8 C9 C10 . . . . -64.8(2) ? C7 C8 C9 C10 . . . . 176.12(14) ? C3 C8 C9 C10 . . . . 60.8(2) ? C8 C9 C10 O33 . . . . 155.68(15) ? C8 C9 C10 C11 . . . . -87.7(2) ? O33 C10 C11 C12 . . . . 95.01(16) ? C9 C10 C11 C12 . . . . -24.3(2) ? O33 C10 C11 C15 . . . . -132.92(15) ? C9 C10 C11 C15 . . . . 107.80(18) ? C15 C11 C12 C13 . . . . -22.0(2) ? C10 C11 C12 C13 . . . . 113.52(18) ? C15 C11 C12 C18 . . . . 155.30(15) ? C10 C11 C12 C18 . . . . -69.16(19) ? C18 C12 C13 C14 . . . . -177.24(16) ? C11 C12 C13 C14 . . . . 0.0(3) ? C12 C13 C14 C1 . . . . -11.1(2) ? O22 C1 C14 C13 . . . . 164.41(13) ? C15 C1 C14 C13 . . . . 44.66(19) ? C2 C1 C14 C13 . . . . -83.13(18) ? O22 C1 C15 C16 . . . . 52.28(18) ? C14 C1 C15 C16 . . . . 170.27(14) ? C2 C1 C15 C16 . . . . -59.38(18) ? O22 C1 C15 C17 . . . . -66.29(17) ? C14 C1 C15 C17 . . . . 51.70(18) ? C2 C1 C15 C17 . . . . -177.95(14) ? O22 C1 C15 C11 . . . . 176.05(12) ? C14 C1 C15 C11 . . . . -65.96(17) ? C2 C1 C15 C11 . . . . 64.39(17) ? C12 C11 C15 C16 . . . . 176.78(14) ? C10 C11 C15 C16 . . . . 43.7(2) ? C12 C11 C15 C1 . . . . 52.87(17) ? C10 C11 C15 C1 . . . . -80.24(17) ? C12 C11 C15 C17 . . . . -66.44(17) ? C10 C11 C15 C17 . . . . 160.45(14) ? C3 C2 O20 C21 . . . . -135.34(14) ? C1 C2 O20 C21 . . . . -4.71(17) ? C2 O20 C21 O23 . . . . -179.45(17) ? C2 O20 C21 O22 . . . . 0.49(18) ? O23 C21 O22 C1 . . . . -175.69(16) ? O20 C21 O22 C1 . . . . 4.37(19) ? C14 C1 O22 C21 . . . . 115.03(15) ? C15 C1 O22 C21 . . . . -124.50(14) ? C2 C1 O22 C21 . . . . -6.83(17) ? C6 C7 O24 C25 . . . . 88.35(17) ? C8 C7 O24 C25 . . . . -146.75(14) ? C7 O24 C25 O26 . . . . -5.8(2) ? C7 O24 C25 C27 . . . . 173.98(13) ? O26 C25 C27 C32 . . . . -171.09(17) ? O24 C25 C27 C32 . . . . 9.1(2) ? O26 C25 C27 C28 . . . . 9.3(3) ? O24 C25 C27 C28 . . . . -170.50(15) ? C32 C27 C28 C29 . . . . 0.5(3) ? C25 C27 C28 C29 . . . . -179.89(16) ? C27 C28 C29 C30 . . . . 0.4(3) ? C28 C29 C30 C31 . . . . -0.5(3) ? C29 C30 C31 C32 . . . . -0.4(3) ? C30 C31 C32 C27 . . . . 1.2(3) ? C28 C27 C32 C31 . . . . -1.3(3) ? C25 C27 C32 C31 . . . . 179.11(16) ? C5 C4 O34 C35 . . . . 99.01(17) ? C3 C4 O34 C35 . . . . -140.30(14) ? C4 O34 C35 O36 . . . . -79.12(18) ? O34 C35 O36 C37 . . . . -71.1(2) ? O22' C1' C2' O20' . . . . 7.02(15) ? C14' C1' C2' O20' . . . . -109.03(15) ? C15' C1' C2' O20' . . . . 123.57(14) ? O22' C1' C2' C3' . . . . 132.64(15) ? C14' C1' C2' C3' . . . . 16.6(2) ? C15' C1' C2' C3' . . . . -110.81(17) ? O20' C2' C3' C4' . . . . 13.44(19) ? C1' C2' C3' C4' . . . . -108.67(17) ? O20' C2' C3' C8' . . . . -114.93(15) ? C1' C2' C3' C8' . . . . 122.97(16) ? C2' C3' C4' O34' . . . . 62.79(17) ? C8' C3' C4' O34' . . . . -172.30(13) ? C2' C3' C4' C5' . . . . -176.44(15) ? C8' C3' C4' C5' . . . . -51.5(2) ? O34' C4' C5' C6' . . . . 172.16(14) ? C3' C4' C5' C6' . . . . 55.1(2) ? C4' C5' C6' C7' . . . . -59.6(2) ? C5' C6' C7' O24' . . . . -177.36(14) ? C5' C6' C7' C8' . . . . 61.9(2) ? O24' C7' C8' C19' . . . . -54.39(18) ? C6' C7' C8' C19' . . . . 67.17(19) ? O24' C7' C8' C9' . . . . 65.65(16) ? C6' C7' C8' C9' . . . . -172.78(14) ? O24' C7' C8' C3' . . . . -176.55(13) ? C6' C7' C8' C3' . . . . -54.99(19) ? C4' C3' C8' C19' . . . . -71.54(18) ? C2' C3' C8' C19' . . . . 55.28(18) ? C4' C3' C8' C7' . . . . 49.07(19) ? C2' C3' C8' C7' . . . . 175.89(14) ? C4' C3' C8' C9' . . . . 163.86(14) ? C2' C3' C8' C9' . . . . -69.33(17) ? C19' C8' C9' C10' . . . . -66.3(2) ? C7' C8' C9' C10' . . . . 174.41(15) ? C3' C8' C9' C10' . . . . 59.1(2) ? C8' C9' C10' O33' . . . . 161.84(15) ? C8' C9' C10' C11' . . . . -82.4(2) ? O33' C10' C11' C12' . . . . 89.06(16) ? C9' C10' C11' C12' . . . . -28.5(2) ? O33' C10' C11' C15' . . . . -138.00(15) ? C9' C10' C11' C15' . . . . 104.46(18) ? C15' C11' C12' C13' . . . . -21.8(2) ? C10' C11' C12' C13' . . . . 115.02(18) ? C15' C11' C12' C18' . . . . 155.27(15) ? C10' C11' C12' C18' . . . . -67.92(19) ? C18' C12' C13' C14' . . . . -177.07(16) ? C11' C12' C13' C14' . . . . -0.2(3) ? C12' C13' C14' C1' . . . . -10.8(2) ? O22' C1' C14' C13' . . . . 164.26(14) ? C15' C1' C14' C13' . . . . 44.01(19) ? C2' C1' C14' C13' . . . . -83.12(18) ? O22' C1' C15' C16' . . . . 51.20(18) ? C14' C1' C15' C16' . . . . 169.96(14) ? C2' C1' C15' C16' . . . . -59.92(18) ? O22' C1' C15' C17' . . . . -66.92(18) ? C14' C1' C15' C17' . . . . 51.83(18) ? C2' C1' C15' C17' . . . . -178.04(14) ? O22' C1' C15' C11' . . . . 175.93(13) ? C14' C1' C15' C11' . . . . -65.31(17) ? C2' C1' C15' C11' . . . . 64.81(17) ? C12' C11' C15' C16' . . . . 176.85(14) ? C10' C11' C15' C16' . . . . 43.1(2) ? C12' C11' C15' C1' . . . . 52.47(17) ? C10' C11' C15' C1' . . . . -81.28(18) ? C12' C11' C15' C17' . . . . -67.12(17) ? C10' C11' C15' C17' . . . . 159.12(14) ? C3' C2' O20' C21' . . . . -136.82(14) ? C1' C2' O20' C21' . . . . -6.71(17) ? C2' O20' C21' O23' . . . . -176.50(16) ? C2' O20' C21' O22' . . . . 3.45(19) ? O23' C21' O22' C1' . . . . -178.39(16) ? O20' C21' O22' C1' . . . . 1.65(19) ? C14' C1' O22' C21' . . . . 116.66(15) ? C15' C1' O22' C21' . . . . -122.43(15) ? C2' C1' O22' C21' . . . . -5.52(17) ? C6' C7' O24' C25' . . . . 91.63(18) ? C8' C7' O24' C25' . . . . -143.73(15) ? C7' O24' C25' O26' . . . . 2.1(3) ? C7' O24' C25' C27' . . . . -178.74(14) ? O26' C25' C27' C28' . . . . 9.8(3) ? O24' C25' C27' C28' . . . . -169.38(16) ? O26' C25' C27' C32' . . . . -170.79(18) ? O24' C25' C27' C32' . . . . 10.0(2) ? C32' C27' C28' C29' . . . . -0.9(3) ? C25' C27' C28' C29' . . . . 178.55(18) ? C27' C28' C29' C30' . . . . 0.7(3) ? C28' C29' C30' C31' . . . . 0.3(3) ? C29' C30' C31' C32' . . . . -1.2(3) ? C30' C31' C32' C27' . . . . 1.0(3) ? C28' C27' C32' C31' . . . . 0.0(3) ? C25' C27' C32' C31' . . . . -179.37(16) ? C5' C4' O34' C35' . . . . 83.68(19) ? C3' C4' O34' C35' . . . . -155.31(15) ? C4' O34' C35' O36' . . . . -79.7(2) ? O34' C35' O36' C37' . . . . -66.5(2) ? C1P C2P C3P C4P . . . . 175.9(6) ? C2P C3P C4P C5P . . . . 179.1(10) ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_site_symmetry_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_publ_flag C14 H14A O34 . 0.99 2.47 3.320(2) 143 yes C14' H14D O34' . 0.99 2.36 3.221(2) 145 yes O33 H33 O22' 2_676 0.84 2.05 2.8563(17) 160 yes O33' H33' O22 2_666 0.84 2.05 2.8839(16) 169 yes C7 H7 O26 2_677 1.00 2.28 3.236(2) 159 yes C4' H4' O36 1_654 1.00 2.40 3.311(2) 151 yes C17' H17F O33 2_676 0.98 2.48 3.431(2) 164 yes C30' H30' O23' 1_545 0.95 2.53 3.453(2) 163 yes C3P H3PB O33 . 0.99 2.49 3.369(9) 149 yes C4P H4PA O33 2_676 0.99 2.41 3.291(12) 148 yes C16' H16D Cg1 2_676 0.98 2.85 3.5315(19) 127 yes _shelx_res_checksum 71931 _iucr_refine_instructions_details ; TITL mo_140916Oishi_0m in P-1 CELL 0.71073 11.33430 15.46660 16.48700 85.1124 78.3773 78.5231 ZERR 4 0.00050 0.00070 0.00080 0.0014 0.0014 0.0015 LATT 1 SFAC C H O UNIT 121 164 32 OMIT 1 1 0 OMIT 9 9 11 OMIT 5 13 11 SHEL 0.84 20 L.S. 4 ACTA 50 BOND $H FMAP 2 PLAN 5 CONF HTAB C14 O34 HTAB C14' O34' EQIV $1 x, y-1, z HTAB O33 O22'_$1 HTAB O33' O22 EQIV $2 -x+1, -y, -z HTAB C7 O26_$2 HTAB C7' O26' EQIV $3 -x+2, -y+1, -z HTAB C4' O36_$3 HTAB C6 O23'_$3 EQIV $4 -x+1, -y+1, -z+1 EQIV $5 x, y+1, z HTAB C17' O33_$5 HTAB C30' O23'_$1 HTAB C30 O23_$1 HTAB C3p O33_$4 HTAB C4p O33_$5 RTAB d2cg C16 C27' C28' C29' C30' C31' C32' RTAB d2cg H16A C27' C28' C29' C30' C31' C32' RTAB d2cg C16' C27_$5 C28_$5 C29_$5 C30_$5 C31_$5 C32_$5 RTAB d2cg H16D C27_$5 C28_$5 C29_$5 C30_$5 C31_$5 C32_$5 MPLA 5 C1 C2 O20 C21 O22 MPLA 4 C14 C13 C12 C11 C15 C1 MPLA 5 C1' C2' O20' C21' O22' MPLA 3 O20' C21' O22' C1' C2' MPLA 4 C14' C13' C12' C11' C15' C1' RTAB dist C2 C10 RTAB dist C2' C10' RTAB dist H2 H10 RTAB dist H2' H10' SIZE 0.170 0.210 0.320 TEMP -183.000 WGHT 0.039000 1.425600 FVAR 0.12049 MOLE 1 C1 1 0.608079 0.281168 0.194538 11.00000 0.01957 0.01237 = 0.02312 -0.00352 -0.00421 -0.00294 C2 1 0.706770 0.232289 0.125814 11.00000 0.01958 0.01454 = 0.01927 -0.00052 -0.00259 -0.00405 AFIX 13 H2 2 0.763355 0.187743 0.154470 11.00000 -1.20000 AFIX 0 C3 1 0.667626 0.183064 0.061445 11.00000 0.01383 0.01482 = 0.02056 -0.00393 -0.00089 -0.00195 AFIX 13 H3 2 0.577311 0.185431 0.078822 11.00000 -1.20000 AFIX 0 C4 1 0.688354 0.227941 -0.025337 11.00000 0.02035 0.01514 = 0.02264 -0.00212 -0.00080 -0.00240 AFIX 13 H4 2 0.776559 0.233008 -0.042847 11.00000 -1.20000 AFIX 0 C5 1 0.651971 0.176888 -0.088030 11.00000 0.02868 0.02156 = 0.01923 -0.00112 -0.00448 -0.00687 AFIX 23 H5A 2 0.670305 0.205664 -0.143919 11.00000 -1.20000 H5B 2 0.562685 0.177493 -0.073898 11.00000 -1.20000 AFIX 0 C6 1 0.721496 0.081550 -0.088662 11.00000 0.02465 0.02280 = 0.02228 -0.00769 -0.00214 -0.00529 AFIX 23 H6A 2 0.696494 0.048704 -0.129340 11.00000 -1.20000 H6B 2 0.810750 0.080426 -0.104926 11.00000 -1.20000 AFIX 0 C7 1 0.692869 0.038796 -0.003026 11.00000 0.01737 0.01460 = 0.02479 -0.00424 -0.00298 -0.00082 AFIX 13 H7 2 0.602654 0.039566 0.011493 11.00000 -1.20000 AFIX 0 C8 1 0.729906 0.083752 0.065655 11.00000 0.01495 0.01664 = 0.01863 -0.00287 -0.00097 -0.00306 C9 1 0.676626 0.038047 0.148465 11.00000 0.01904 0.01541 = 0.02405 -0.00365 -0.00380 -0.00142 AFIX 23 H9B 2 0.588350 0.041514 0.148858 11.00000 -1.20000 H9A 2 0.714994 -0.025264 0.145775 11.00000 -1.20000 AFIX 0 C10 1 0.685906 0.067291 0.233844 11.00000 0.01952 0.01588 = 0.02192 0.00186 -0.00342 -0.00117 AFIX 13 H10 2 0.767379 0.084692 0.229657 11.00000 -1.20000 AFIX 0 C11 1 0.583134 0.141906 0.276402 11.00000 0.01892 0.01881 = 0.01633 -0.00096 -0.00134 -0.00273 AFIX 13 H11 2 0.565464 0.120479 0.335765 11.00000 -1.20000 AFIX 0 C12 1 0.462155 0.149885 0.247456 11.00000 0.01877 0.02198 = 0.01829 -0.00488 0.00015 -0.00310 C13 1 0.417048 0.220725 0.204263 11.00000 0.01534 0.02552 = 0.02191 -0.00482 -0.00297 -0.00186 AFIX 43 H13 2 0.340971 0.221765 0.188005 11.00000 -1.20000 AFIX 0 C14 1 0.477401 0.299081 0.179329 11.00000 0.02004 0.01718 = 0.02111 -0.00346 -0.00352 0.00220 AFIX 23 H14A 2 0.429391 0.350123 0.211209 11.00000 -1.20000 H14B 2 0.478018 0.314637 0.119760 11.00000 -1.20000 AFIX 0 C15 1 0.615361 0.234723 0.279978 11.00000 0.01852 0.01945 = 0.01882 -0.00333 -0.00246 -0.00266 C16 1 0.740544 0.229362 0.304262 11.00000 0.02548 0.02248 = 0.02094 -0.00260 -0.00703 -0.00423 AFIX 137 H16A 2 0.805889 0.208404 0.257714 11.00000 -1.50000 H16B 2 0.747119 0.188222 0.352448 11.00000 -1.50000 H16C 2 0.748537 0.288036 0.318126 11.00000 -1.50000 AFIX 0 C17 1 0.520488 0.285227 0.348345 11.00000 0.02626 0.02202 = 0.02201 -0.00444 -0.00380 -0.00201 AFIX 137 H17B 2 0.532486 0.258030 0.402692 11.00000 -1.50000 H17C 2 0.437686 0.282927 0.340628 11.00000 -1.50000 H17A 2 0.530826 0.346912 0.345288 11.00000 -1.50000 AFIX 0 C18 1 0.393157 0.075529 0.273332 11.00000 0.02317 0.02675 = 0.03274 -0.00056 -0.00342 -0.00505 AFIX 137 H18A 2 0.360266 0.076676 0.333026 11.00000 -1.50000 H18B 2 0.448661 0.019091 0.260768 11.00000 -1.50000 H18C 2 0.325527 0.082304 0.243086 11.00000 -1.50000 AFIX 0 C19 1 0.869453 0.070885 0.052835 11.00000 0.01782 0.01878 = 0.02693 -0.00707 -0.00252 -0.00126 AFIX 137 H19C 2 0.892433 0.099486 0.096611 11.00000 -1.50000 H19A 2 0.901209 0.097295 -0.001318 11.00000 -1.50000 H19B 2 0.904248 0.007620 0.054987 11.00000 -1.50000 AFIX 0 O20 3 0.776001 0.299433 0.086636 11.00000 0.02052 0.01916 = 0.02493 -0.00522 0.00031 -0.00766 C21 1 0.737603 0.374196 0.126399 11.00000 0.02304 0.02065 = 0.02248 -0.00230 -0.00715 -0.00407 O22 3 0.645685 0.367018 0.190706 11.00000 0.02454 0.01526 = 0.02415 -0.00377 -0.00152 -0.00465 O23 3 0.778938 0.439866 0.107921 11.00000 0.03599 0.02108 = 0.03529 -0.00126 -0.00497 -0.01410 O24 3 0.757282 -0.053556 -0.001964 11.00000 0.01932 0.01465 = 0.02707 -0.00647 -0.00425 -0.00268 C25 1 0.698477 -0.113597 -0.021526 11.00000 0.01867 0.02051 = 0.02035 -0.00513 -0.00212 -0.00440 O26 3 0.602265 -0.095111 -0.045461 11.00000 0.02515 0.02208 = 0.04030 -0.00692 -0.01272 -0.00155 C27 1 0.764020 -0.205887 -0.010398 11.00000 0.02327 0.01803 = 0.01582 -0.00329 -0.00120 -0.00259 C28 1 0.702721 -0.273791 -0.016767 11.00000 0.02402 0.02291 = 0.02359 -0.00537 -0.00592 -0.00402 AFIX 43 H28 2 0.621786 -0.260189 -0.027777 11.00000 -1.20000 AFIX 0 C29 1 0.758800 -0.360721 -0.007187 11.00000 0.03724 0.01940 = 0.02711 -0.00441 -0.00701 -0.00774 AFIX 43 H29 2 0.716324 -0.406820 -0.011267 11.00000 -1.20000 AFIX 0 C30 1 0.876568 -0.380764 0.008320 11.00000 0.03468 0.01729 = 0.02540 -0.00092 -0.00114 0.00288 AFIX 43 H30 2 0.915302 -0.440701 0.014509 11.00000 -1.20000 AFIX 0 C31 1 0.938270 -0.314009 0.014868 11.00000 0.01844 0.02875 = 0.03141 0.00127 -0.00194 0.00178 AFIX 43 H31 2 1.019538 -0.328137 0.025245 11.00000 -1.20000 AFIX 0 C32 1 0.882119 -0.226435 0.006363 11.00000 0.02119 0.02334 = 0.02329 -0.00180 -0.00109 -0.00705 AFIX 43 H32 2 0.924173 -0.180565 0.011965 11.00000 -1.20000 AFIX 0 O33 3 0.677814 -0.006338 0.291951 11.00000 0.03423 0.01817 = 0.02590 0.00193 -0.00259 0.00144 AFIX 147 H33 2 0.733619 -0.049021 0.275359 11.00000 -1.50000 AFIX 0 O34 3 0.612988 0.315080 -0.018133 11.00000 0.02547 0.01506 = 0.02375 0.00062 -0.00295 -0.00355 C35 1 0.665606 0.383537 -0.062992 11.00000 0.02985 0.01865 = 0.02740 0.00294 -0.00761 -0.00727 AFIX 23 H35A 2 0.622585 0.440299 -0.038674 11.00000 -1.20000 H35B 2 0.752296 0.375011 -0.056772 11.00000 -1.20000 AFIX 0 O36 3 0.661334 0.389057 -0.146833 11.00000 0.03210 0.02983 = 0.02288 0.00512 -0.00483 -0.00507 C37 1 0.541244 0.419901 -0.162724 11.00000 0.04525 0.04408 = 0.05341 0.01457 -0.02869 -0.01239 AFIX 137 H37B 2 0.486798 0.380688 -0.133477 11.00000 -1.50000 H37C 2 0.542984 0.420470 -0.222436 11.00000 -1.50000 H37A 2 0.510999 0.479852 -0.143237 11.00000 -1.50000 AFIX 0 C1' 1 0.805252 0.741950 0.310379 11.00000 0.02107 0.01123 = 0.02433 -0.00004 -0.00326 -0.00385 C2' 1 0.909130 0.672892 0.263593 11.00000 0.01754 0.01802 = 0.02092 0.00081 -0.00337 -0.00678 AFIX 13 H2' 2 0.871123 0.642251 0.227368 11.00000 -1.20000 AFIX 0 C3' 1 0.981953 0.600490 0.313780 11.00000 0.01853 0.01714 = 0.01813 -0.00032 -0.00311 -0.00202 AFIX 13 H3' 2 0.939680 0.605200 0.373073 11.00000 -1.20000 AFIX 0 C4' 1 1.113101 0.614370 0.309818 11.00000 0.02036 0.02215 = 0.02609 -0.00308 -0.00560 -0.00439 AFIX 13 H4' 2 1.155115 0.619195 0.250598 11.00000 -1.20000 AFIX 0 C5' 1 1.186055 0.539555 0.355043 11.00000 0.01933 0.02988 = 0.03411 0.00173 -0.00971 -0.00420 AFIX 23 H5'A 2 1.150546 0.539666 0.415042 11.00000 -1.20000 H5'B 2 1.271795 0.548331 0.347810 11.00000 -1.20000 AFIX 0 C6' 1 1.184242 0.451218 0.321626 11.00000 0.02370 0.02188 = 0.03180 0.00114 -0.00847 0.00297 AFIX 23 H6'A 2 1.221805 0.450091 0.261972 11.00000 -1.20000 H6'B 2 1.232072 0.402763 0.351442 11.00000 -1.20000 AFIX 0 C7' 1 1.053319 0.438774 0.333675 11.00000 0.02417 0.01758 = 0.02238 -0.00311 -0.00483 -0.00089 AFIX 13 H7' 2 1.017213 0.440485 0.394214 11.00000 -1.20000 AFIX 0 C8' 1 0.971534 0.508818 0.286776 11.00000 0.01893 0.01747 = 0.01991 -0.00218 -0.00428 -0.00186 C9' 1 0.839016 0.491540 0.316293 11.00000 0.02399 0.01441 = 0.02377 -0.00336 -0.00526 -0.00330 AFIX 23 H9'A 2 0.824482 0.488563 0.377637 11.00000 -1.20000 H9'B 2 0.839986 0.431407 0.299521 11.00000 -1.20000 AFIX 0 C10' 1 0.722909 0.550879 0.291705 11.00000 0.02068 0.01679 = 0.02212 -0.00299 -0.00450 -0.00633 AFIX 13 H10' 2 0.740086 0.566721 0.230946 11.00000 -1.20000 AFIX 0 C11' 1 0.661332 0.636311 0.339784 11.00000 0.01704 0.01718 = 0.02308 -0.00384 -0.00316 -0.00389 AFIX 13 H11' 2 0.571480 0.637657 0.345420 11.00000 -1.20000 AFIX 0 C12' 1 0.681111 0.629356 0.428790 11.00000 0.01786 0.01627 = 0.02143 -0.00392 -0.00100 -0.00027 C13' 1 0.745889 0.680571 0.454396 11.00000 0.02128 0.02323 = 0.01811 -0.00433 -0.00310 -0.00207 AFIX 43 H13' 2 0.754797 0.673226 0.510780 11.00000 -1.20000 AFIX 0 C14' 1 0.805991 0.748960 0.401474 11.00000 0.02165 0.01948 = 0.02595 -0.00666 -0.00408 -0.00424 AFIX 23 H14D 2 0.891735 0.741848 0.409425 11.00000 -1.20000 H14E 2 0.762518 0.808395 0.419128 11.00000 -1.20000 AFIX 0 C15' 1 0.679502 0.728069 0.297902 11.00000 0.02022 0.01529 = 0.02452 -0.00424 -0.00468 -0.00235 C16' 1 0.667545 0.736827 0.206535 11.00000 0.02348 0.02032 = 0.02708 0.00015 -0.00745 -0.00140 AFIX 137 H16D 2 0.736238 0.697384 0.174295 11.00000 -1.50000 H16E 2 0.668561 0.797979 0.185660 11.00000 -1.50000 H16F 2 0.590184 0.720724 0.201191 11.00000 -1.50000 AFIX 0 C17' 1 0.575062 0.798055 0.341443 11.00000 0.02111 0.01811 = 0.03192 -0.00392 -0.00515 -0.00225 AFIX 137 H17D 2 0.571421 0.791140 0.401487 11.00000 -1.50000 H17E 2 0.496989 0.790429 0.328805 11.00000 -1.50000 H17F 2 0.590269 0.857164 0.321763 11.00000 -1.50000 AFIX 0 C18' 1 0.618464 0.565086 0.486202 11.00000 0.02650 0.02521 = 0.02634 -0.00331 -0.00141 -0.00498 AFIX 137 H18D 2 0.529435 0.583811 0.492148 11.00000 -1.50000 H18E 2 0.641652 0.563070 0.540569 11.00000 -1.50000 H18F 2 0.643264 0.506275 0.463497 11.00000 -1.50000 AFIX 0 C19' 1 1.013019 0.498933 0.192985 11.00000 0.02583 0.01944 = 0.02428 -0.00294 -0.00461 -0.00014 AFIX 137 H19D 2 1.025281 0.436561 0.180600 11.00000 -1.50000 H19E 2 1.090170 0.520455 0.174238 11.00000 -1.50000 H19F 2 0.950103 0.533469 0.164214 11.00000 -1.50000 AFIX 0 O20' 3 0.988776 0.725155 0.208989 11.00000 0.02052 0.01841 = 0.02485 0.00332 -0.00212 -0.00394 C21' 1 0.938565 0.810588 0.211838 11.00000 0.02039 0.02159 = 0.02595 0.00070 -0.00792 -0.00640 O22' 3 0.833027 0.824628 0.267205 11.00000 0.02259 0.01481 = 0.03027 0.00088 -0.00210 -0.00429 O23' 3 0.981355 0.867927 0.170533 11.00000 0.02982 0.02418 = 0.03449 0.00669 -0.00592 -0.01150 O24' 3 1.050916 0.352590 0.305443 11.00000 0.02944 0.01544 = 0.02346 -0.00163 -0.00692 0.00072 C25' 1 1.052851 0.284734 0.361617 11.00000 0.02036 0.02355 = 0.02551 0.00109 -0.00771 -0.00233 O26' 3 1.053091 0.291553 0.433588 11.00000 0.06256 0.02636 = 0.02678 0.00127 -0.01784 -0.01354 C27' 1 1.052849 0.200287 0.324522 11.00000 0.01835 0.01946 = 0.03013 -0.00208 -0.00749 -0.00063 C28' 1 1.034070 0.128204 0.377772 11.00000 0.04198 0.02703 = 0.02909 -0.00121 -0.00586 -0.00666 AFIX 43 H28' 2 1.023598 0.133216 0.435926 11.00000 -1.20000 AFIX 0 C29' 1 1.030512 0.048662 0.346384 11.00000 0.05229 0.02170 = 0.04573 0.00003 -0.00266 -0.01118 AFIX 43 H29' 2 1.016691 -0.000603 0.383114 11.00000 -1.20000 AFIX 0 C30' 1 1.046933 0.040838 0.262208 11.00000 0.03368 0.02600 = 0.04398 -0.01209 -0.00336 -0.00730 AFIX 43 H30' 2 1.044013 -0.013689 0.240866 11.00000 -1.20000 AFIX 0 C31' 1 1.067565 0.111895 0.208960 11.00000 0.01909 0.03038 = 0.03148 -0.01151 -0.00296 -0.00221 AFIX 43 H31' 2 1.080415 0.105942 0.150803 11.00000 -1.20000 AFIX 0 C32' 1 1.069750 0.192027 0.239473 11.00000 0.01407 0.02420 = 0.03047 -0.00287 -0.00481 -0.00081 AFIX 43 H32' 2 1.082750 0.241220 0.202446 11.00000 -1.20000 AFIX 0 O33' 3 0.628469 0.498280 0.308851 11.00000 0.02585 0.01940 = 0.03401 -0.00955 -0.00566 -0.00783 AFIX 147 H33' 2 0.643496 0.459451 0.273637 11.00000 -1.50000 AFIX 0 O34' 3 1.099628 0.696985 0.347776 11.00000 0.02305 0.02304 = 0.03338 -0.00168 -0.00845 -0.00825 C35' 1 1.197837 0.741508 0.323385 11.00000 0.04188 0.03938 = 0.03645 -0.00095 -0.00646 -0.02446 AFIX 23 H35D 2 1.226427 0.737543 0.262751 11.00000 -1.20000 H35F 2 1.168473 0.804720 0.335008 11.00000 -1.20000 AFIX 0 O36' 3 1.296545 0.709118 0.362551 11.00000 0.02214 0.05213 = 0.06439 -0.02202 -0.00809 -0.01027 C37' 1 1.268734 0.722956 0.448175 11.00000 0.05004 0.05924 = 0.06018 -0.01119 -0.03118 -0.01120 AFIX 137 H37D 2 1.341518 0.699827 0.472478 11.00000 -1.50000 H37E 2 1.202095 0.692314 0.474704 11.00000 -1.50000 H37F 2 1.243235 0.786355 0.456926 11.00000 -1.50000 AFIX 0 PART -1 MOLE 2 C1P 1 0.243697 0.999136 0.509595 10.50000 0.03988 0.05445 = 0.04451 -0.00726 -0.00661 -0.00602 AFIX 137 H1PA 2 0.219151 1.009503 0.568962 10.50000 -1.50000 H1PB 2 0.194315 0.959916 0.494480 10.50000 -1.50000 H1PC 2 0.230714 1.055539 0.477746 10.50000 -1.50000 AFIX 0 C2P 1 0.377808 0.956623 0.490456 10.50000 0.04661 0.02872 = 0.02632 -0.00545 -0.00575 -0.00215 AFIX 23 H2PA 2 0.400212 0.941985 0.431359 10.50000 -1.20000 H2PB 2 0.390634 0.900693 0.524238 10.50000 -1.20000 AFIX 0 C3P 1 0.462368 1.015559 0.507676 10.50000 0.05717 0.02160 = 0.02071 -0.00756 0.00753 -0.00048 AFIX 23 H3PA 2 0.453585 1.069604 0.470955 10.50000 -1.20000 H3PB 2 0.435734 1.033802 0.565649 10.50000 -1.20000 AFIX 0 C4P 1 0.596153 0.971856 0.494721 10.50000 0.05388 0.04170 = 0.03068 -0.00426 0.00225 -0.00254 AFIX 23 H4PA 2 0.622784 0.952797 0.437006 10.50000 -1.20000 H4PB 2 0.605488 0.918427 0.532182 10.50000 -1.20000 AFIX 0 C5P 1 0.678808 1.032125 0.510814 10.50000 0.04687 0.05066 = 0.03954 0.00786 -0.00282 -0.01083 AFIX 137 H5PA 2 0.674143 1.083351 0.471495 10.50000 -1.50000 H5PB 2 0.763552 0.999750 0.503790 10.50000 -1.50000 H5PC 2 0.652062 1.052161 0.567541 10.50000 -1.50000 PART AFIX 0 HKLF 4 REM mo_140916Oishi_0m in P-1 REM R1 = 0.0400 for 7339 Fo > 4sig(Fo) and 0.0636 for all 9735 data REM 726 parameters refined using 0 restraints END WGHT 0.0390 1.3983 REM Highest difference peak 0.272, deepest hole -0.235, 1-sigma level 0.045 Q1 1 0.4176 0.2031 0.2577 11.00000 0.05 0.27 Q2 1 0.9767 0.5554 0.2987 11.00000 0.05 0.26 Q3 1 0.5813 -0.0962 0.0225 11.00000 0.05 0.26 Q4 1 0.9387 0.6352 0.2929 11.00000 0.05 0.25 Q5 1 0.6559 0.2459 0.1675 11.00000 0.05 0.24 ; data_B _database_code_depnum_ccdc_archive 'CCDC 1057984' _chemical_name_systematic ;\ (+-)-(1SR,5SR,6SR,7SR,10SR,11SR,\ 13SR,14SR)-13-Hydroxy-7-methoxymethoxy-11,15,18,18-\ tetramethyl-3-oxo-2,4-dioxatetracyclo[12.3.1.0^1,5^.0^6,11^]octadec-15-en-10-yl benzoate ; _chemical_name_common ? _chemical_formula_moiety 'C29 H38 O8' _chemical_formula_sum 'C29 H38 O8' _chemical_formula_iupac 'C29 H38 O8' _chemical_formula_weight 514.59 _chemical_melting_point 489.2 _space_group_crystal_system monoclinic _space_group_name_H-M_alt 'P 1 21/n 1' _space_group_name_Hall '-P 2yn' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x+1/2, y+1/2, -z+1/2' '-x, -y, -z' 'x-1/2, -y-1/2, z-1/2' _cell_length_a 9.3612(6) _cell_length_b 19.6336(15) _cell_length_c 14.1965(9) _cell_angle_alpha 90 _cell_angle_beta 101.762(2) _cell_angle_gamma 90 _cell_volume 2554.4(3) _cell_formula_units_Z 4 _cell_measurement_reflns_used 4716 _cell_measurement_theta_min 2.40 _cell_measurement_theta_max 23.92 _cell_measurement_temperature 90.0 _exptl_crystal_description prism _exptl_crystal_colour colorless _exptl_crystal_size_max 0.230 _exptl_crystal_size_mid 0.230 _exptl_crystal_size_min 0.140 _exptl_crystal_density_diffrn 1.338 _exptl_crystal_density_meas ? _exptl_crystal_density_method 'not measured' _exptl_crystal_F_000 1104 _exptl_absorpt_coefficient_mu 0.097 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; (SADABS; Bruker, 2014) ; _exptl_absorpt_correction_T_min 0.98 _exptl_absorpt_correction_T_max 0.99 _exptl_special_details ; M.p. 488.2--489.2 K (not corrected); IR (film) 3483, 2940, 1799, 1717, 1274, 1099, 1042, 773 cm^-1^; ^1^H NMR (500 MHz, CDCl~3~, at 333 K) \d (p.p.m.) 8.02 (d, J = 7.7 Hz, 2H), 7.58 (t, J = 7.5 Hz, 1H), 7.46 (t, J = 7.7 Hz, 2H), 5.50 (s, 1H), 4.92 (d, J = 4.3 Hz, 1H), 4.91 (dd J = 11.7, 4.9 Hz, 1H), 4.80 (d, J = 6.9 Hz, 1H), 4.64 (d, J = 6.9 Hz, 1H), 4.31 (d, J = 10.9 Hz, 1H), 3.68 (ddd, J = 10.9, 10.6, 4.9 Hz, 1H), 3.39 (s, 3H), 3.19 (d, J = 16.9 Hz, 1H), 2.42 (dd, J = 10.9, 4.3 Hz, 1H), 2.33 (s, 1H), 2.33--2.27 (m, 1H), 2.26 (d, J = 16.9 Hz, 1H), 2.02 (dd, J = 16.0, 10.9 Hz, 1H), 1.95--1.87 (m, 1H), 1.88 (s, 3H), 1.82 (dddd, J = 13.6, 13.6, 13.6, 4.6 Hz, 1H), 1.72 (d, J = 16.0 Hz, 1H), 1.49--1.40 (m, 1H), 1.46 (s, 1H), 1.41 (s, 3H), 1.20 (s, 3H), 1.18 (s, 3H); ^13^C NMR (125 MHz, CDCl~3~, at 333 K) \d (p.p.m.) 166.3 (C), 154.4 (C), 136.3 (C), 133.4 (CH), 130.4 (C), 129.8 (CH), 128.7 (CH), 122.3 (CH), 97.7 (CH~2~), 88.5 (C), 79.5 (CH), 75.2 (CH), 74.3 (CH), 70.3 (CH), 60.0 (CH), 56.1 (CH~3~), 44.8 (CH~2~), 44.2 (CH), 42.0 (C), 39.0 (C), 32.0 (CH~2~), 30.7 (CH~2~), 28.6 (CH~3~), 25.6 (CH~2~), 22.9 (CH~3~), 20.8 (CH~3~), 16.1 (CH~3~); LRMS (EI) m/z 514 (M^+^, 3%), 483 (1), 469 (1), 453 (1), 409 (2), 393 (6), 348 (1), 332 (2), 121 (78), 105 (100), 77 (59); HRMS (EI) m/z calcd for C~29~H~38~O~8~^+^ [M]^+^ 514.2567, found 514.2560. ; _diffrn_ambient_temperature 90.0 _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_radiation_monochromator 'multilayered confocal mirror' _diffrn_measurement_device_type 'Bruker D8 Venture' _diffrn_measurement_method '\f and \w scans' _diffrn_detector_area_resol_mean 8.333 _diffrn_reflns_number 23252 _diffrn_reflns_av_R_equivalents 0.0579 _diffrn_reflns_av_sigmaI/netI ? _diffrn_reflns_theta_min 2.45 _diffrn_reflns_theta_max 25.03 _diffrn_reflns_theta_full 25.03 _diffrn_measured_fraction_theta_max 0.995 _diffrn_measured_fraction_theta_full 0.995 _diffrn_reflns_limit_h_min -11 _diffrn_reflns_limit_h_max 11 _diffrn_reflns_limit_k_min -23 _diffrn_reflns_limit_k_max 21 _diffrn_reflns_limit_l_min -16 _diffrn_reflns_limit_l_max 16 _diffrn_standards_number 0 _diffrn_standards_interval_count ? _diffrn_standards_decay_% ? _refine_special_details ; Refinement of F^2^ against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F^2^, conventional R-factors R are based on F, with F set to zero for negative F^2^. The threshold expression of F^2^ > \s(F^2^) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F^2^ are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. Problematic one reflection with |I(obs)-I(calc)|/\sW(I) greater than 10 (-1 0 1) has been omitted in the final refinement. ; _reflns_number_total 4480 _reflns_number_gt 3212 _reflns_threshold_expression 'I > 2\s(I)' _refine_ls_structure_factor_coef Fsqd _refine_ls_matrix_type full _refine_ls_R_factor_all 0.0733 _refine_ls_R_factor_gt 0.0428 _refine_ls_wR_factor_gt 0.0978 _refine_ls_wR_factor_ref 0.1111 _refine_ls_goodness_of_fit_ref 1.020 _refine_ls_restrained_S_all 1.020 _refine_ls_number_reflns 4480 _refine_ls_number_parameters 340 _refine_ls_number_restraints 0 _refine_ls_number_constraints ? _refine_ls_hydrogen_treatment constr _refine_ls_weighting_scheme calc _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0540P)^2^+1.0752P] where P=(Fo^2^+2Fc^2^)/3' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary difmap _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_diff_density_max 0.511 _refine_diff_density_min -0.212 _refine_ls_extinction_method none _refine_ls_extinction_coef ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _computing_data_collection ; APEX2 (Bruker, 2014) ; _computing_cell_refinement ; SAINT (Bruker, 2014) ; _computing_data_reduction ; SAINT (Bruker, 2014) ; _computing_structure_solution ; SHELXS2013 (Sheldrick, 2008) ; _computing_structure_refinement ; SHELXL2014 (Sheldrick, 2015) ; _computing_molecular_graphics ; Mercury (Macrae et al., 2006) ; _computing_publication_material ; publCif (Westrip, 2010) and PLATON (Spek, 2009) ; loop_ _atom_site_type_symbol _atom_site_label _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_calc_flag _atom_site_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C C1 0.7169(2) 0.18654(10) 0.68618(13) 0.0143(4) Uani d 1 . . C C2 0.6544(2) 0.17259(10) 0.77738(14) 0.0136(4) Uani d 1 . . H H2 0.6782 0.2123 0.8195 0.016 Uiso calc 1 . . C C3 0.7047(2) 0.10935(10) 0.83870(13) 0.0131(4) Uani d 1 . . H H3 0.7884 0.0905 0.8158 0.016 Uiso calc 1 . . C C4 0.5888(2) 0.05350(10) 0.82692(14) 0.0157(5) Uani d 1 . . H H4 0.5005 0.0711 0.8454 0.019 Uiso calc 1 . . C C5 0.6453(2) -0.00784(10) 0.88896(14) 0.0181(5) Uani d 1 . . H H5A 0.7279 -0.0275 0.8671 0.022 Uiso calc 1 . . H H5B 0.5695 -0.0422 0.8827 0.022 Uiso calc 1 . . C C6 0.6915(2) 0.01330(11) 0.99391(14) 0.0192(5) Uani d 1 . . H H6A 0.6073 0.0301 1.0169 0.023 Uiso calc 1 . . H H6B 0.7295 -0.026 1.0325 0.023 Uiso calc 1 . . C C7 0.8069(2) 0.06816(10) 1.00523(13) 0.0155(4) Uani d 1 . . H H7 0.8952 0.0491 0.9884 0.019 Uiso calc 1 . . C C8 0.7615(2) 0.13268(10) 0.94372(14) 0.0135(4) Uani d 1 . . C C9 0.9051(2) 0.17425(10) 0.94939(14) 0.0164(5) Uani d 1 . . H H9B 0.9393 0.1848 1.017 0.02 Uiso calc 1 . . H H9A 0.9752 0.1424 0.9326 0.02 Uiso calc 1 . . C C10 0.9238(2) 0.24112(10) 0.89436(14) 0.0166(5) Uani d 1 . . H H10 1.0181 0.259 0.9281 0.02 Uiso calc 1 . . C C11 0.9370(2) 0.24049(10) 0.78491(14) 0.0172(5) Uani d 1 . . H H11 1.0036 0.2782 0.7801 0.021 Uiso calc 1 . . C C12 1.0208(2) 0.17776(11) 0.76571(14) 0.0174(5) Uani d 1 . . C C13 0.9588(2) 0.12865(10) 0.70699(14) 0.0167(5) Uani d 1 . . H H13 1.0156 0.0911 0.6989 0.02 Uiso calc 1 . . C C14 0.8037(2) 0.12964(10) 0.65293(14) 0.0154(4) Uani d 1 . . H H14A 0.7581 0.0864 0.6617 0.018 Uiso calc 1 . . H H14B 0.8021 0.1351 0.5848 0.018 Uiso calc 1 . . C C15 0.8037(2) 0.25338(10) 0.69973(14) 0.0154(5) Uani d 1 . . C C16 0.7084(2) 0.31455(10) 0.71360(14) 0.0191(5) Uani d 1 . . H H16B 0.6447 0.3255 0.6535 0.029 Uiso calc 1 . . H H16C 0.7695 0.353 0.7355 0.029 Uiso calc 1 . . H H16A 0.6512 0.3035 0.7604 0.029 Uiso calc 1 . . C C17 0.8650(2) 0.27030(11) 0.60997(15) 0.0209(5) Uani d 1 . . H H17A 0.9377 0.2373 0.6029 0.031 Uiso calc 1 . . H H17B 0.908 0.3149 0.6168 0.031 Uiso calc 1 . . H H17C 0.7874 0.2693 0.5541 0.031 Uiso calc 1 . . C C18 1.1796(2) 0.17407(12) 0.81421(16) 0.0242(5) Uani d 1 . . H H18B 1.2193 0.1311 0.7998 0.036 Uiso calc 1 . . H H18C 1.1887 0.1783 0.8825 0.036 Uiso calc 1 . . H H18A 1.232 0.2104 0.7912 0.036 Uiso calc 1 . . C C19 0.6461(2) 0.17224(11) 0.98432(14) 0.0176(5) Uani d 1 . . H H19C 0.6149 0.2111 0.9444 0.026 Uiso calc 1 . . H H19A 0.6873 0.1871 1.0485 0.026 Uiso calc 1 . . H H19B 0.5639 0.1432 0.9854 0.026 Uiso calc 1 . . O O20 0.49732(15) 0.17278(7) 0.74303(9) 0.0176(3) Uani d 1 . . C C21 0.4646(2) 0.18489(10) 0.64927(15) 0.0178(5) Uani d 1 . . O O22 0.58327(14) 0.19463(7) 0.61213(9) 0.0170(3) Uani d 1 . . O O23 0.34190(16) 0.18696(8) 0.60281(10) 0.0247(4) Uani d 1 . . O O24 0.84116(15) 0.09012(7) 1.10583(9) 0.0168(3) Uani d 1 . . C C25 0.9381(2) 0.05274(10) 1.16731(14) 0.0154(4) Uani d 1 . . O O26 1.00007(16) 0.00371(7) 1.14311(10) 0.0237(4) Uani d 1 . . C C27 0.9612(2) 0.07873(10) 1.26731(14) 0.0153(4) Uani d 1 . . C C28 0.8754(2) 0.13006(11) 1.29508(14) 0.0194(5) Uani d 1 . . H H28 0.7979 0.1484 1.2508 0.023 Uiso calc 1 . . C C29 0.9062(2) 0.15358(12) 1.38896(15) 0.0252(5) Uani d 1 . . H H29 0.8491 0.1878 1.4077 0.03 Uiso calc 1 . . C C30 1.0214(2) 0.12650(11) 1.45491(15) 0.0231(5) Uani d 1 . . H H30 1.0417 0.1428 1.5178 0.028 Uiso calc 1 . . C C31 1.1063(2) 0.07552(11) 1.42812(15) 0.0227(5) Uani d 1 . . H H31 1.1832 0.0571 1.4728 0.027 Uiso calc 1 . . C C32 1.0765(2) 0.05194(10) 1.33430(14) 0.0187(5) Uani d 1 . . H H32 1.1342 0.0179 1.316 0.022 Uiso calc 1 . . O O33 0.82270(15) 0.29278(7) 0.90665(10) 0.0200(3) Uani d 1 . . H H33 0.8271 0.2993 0.9642 0.03 Uiso calc 1 . . O O34 0.55698(14) 0.03544(7) 0.72690(9) 0.0188(3) Uani d 1 . . C C35 0.4129(2) 0.01081(12) 0.69395(15) 0.0232(5) Uani d 1 . . H H35A 0.3957 -0.0281 0.7322 0.028 Uiso calc 1 . . H H35B 0.343 0.046 0.7007 0.028 Uiso calc 1 . . O O36 0.39527(17) -0.00779(8) 0.59939(11) 0.0289(4) Uani d 1 . . C C37 0.4715(3) -0.06965(12) 0.58715(17) 0.0315(6) Uani d 1 . . H H37C 0.5739 -0.0637 0.6126 0.047 Uiso calc 1 . . H H37A 0.4566 -0.0805 0.5199 0.047 Uiso calc 1 . . H H37B 0.4349 -0.1061 0.6207 0.047 Uiso calc 1 . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_12 _atom_site_aniso_U_13 _atom_site_aniso_U_23 C1 0.0139(11) 0.0176(11) 0.0096(10) 0.0000(9) -0.0017(8) 0.0003(8) C2 0.0092(10) 0.0182(11) 0.0126(10) 0.0005(8) 0.0003(8) -0.0006(8) C3 0.0116(11) 0.0156(10) 0.0126(11) 0.0014(8) 0.0039(8) -0.0003(8) C4 0.0154(11) 0.0203(11) 0.0114(11) -0.0014(9) 0.0026(9) -0.0038(8) C5 0.0187(11) 0.0147(11) 0.0216(12) -0.0040(9) 0.0060(9) -0.0018(9) C6 0.0218(12) 0.0190(11) 0.0174(11) -0.0008(9) 0.0052(9) 0.0041(9) C7 0.0192(11) 0.0184(11) 0.0091(10) 0.0018(9) 0.0030(9) -0.0003(8) C8 0.0132(11) 0.0142(11) 0.0129(11) 0.0003(8) 0.0025(8) -0.0007(8) C9 0.0167(11) 0.0174(11) 0.0133(11) 0.0010(9) -0.0009(9) -0.0013(8) C10 0.0154(11) 0.0171(11) 0.0162(11) -0.0002(9) 0.0010(9) -0.0025(8) C11 0.0153(11) 0.0185(11) 0.0179(11) -0.0039(9) 0.0039(9) -0.0010(9) C12 0.0160(11) 0.0205(11) 0.0170(11) -0.0006(9) 0.0067(9) -0.0004(9) C13 0.0176(11) 0.0178(11) 0.0162(11) 0.0030(9) 0.0071(9) 0.0015(9) C14 0.0200(11) 0.0156(11) 0.0118(11) 0.0001(9) 0.0059(9) -0.0001(8) C15 0.0170(11) 0.0153(11) 0.0141(11) 0.0000(9) 0.0040(9) 0.0005(8) C16 0.0217(12) 0.0188(11) 0.0152(11) 0.0028(9) 0.0003(9) 0.0027(8) C17 0.0248(12) 0.0187(11) 0.0207(12) -0.0029(9) 0.0079(10) 0.0009(9) C18 0.0184(12) 0.0282(13) 0.0263(13) 0.0004(10) 0.0052(10) -0.0049(10) C19 0.0199(12) 0.0188(11) 0.0140(11) 0.0016(9) 0.0032(9) 0.0003(8) O20 0.0137(8) 0.0265(8) 0.0119(8) 0.0036(6) 0.0011(6) 0.0032(6) C21 0.0195(13) 0.0173(11) 0.0167(12) -0.0003(9) 0.0041(10) 0.0018(9) O22 0.0152(8) 0.0225(8) 0.0124(7) 0.0000(6) 0.0007(6) 0.0024(6) O23 0.0157(9) 0.0375(10) 0.0189(8) 0.0007(7) -0.0014(7) 0.0077(7) O24 0.0197(8) 0.0197(8) 0.0101(7) 0.0043(6) 0.0011(6) 0.0004(6) C25 0.0159(11) 0.0149(11) 0.0154(11) -0.0005(9) 0.0033(9) 0.0034(8) O26 0.0295(9) 0.0225(8) 0.0179(8) 0.0102(7) 0.0023(7) -0.0004(6) C27 0.0173(11) 0.0139(10) 0.0152(11) -0.0024(9) 0.0042(9) 0.0024(8) C28 0.0175(12) 0.0242(12) 0.0158(12) 0.0022(9) 0.0021(9) 0.0018(9) C29 0.0241(13) 0.0317(13) 0.0203(13) 0.0071(10) 0.0060(10) -0.0027(10) C30 0.0268(13) 0.0293(13) 0.0135(11) -0.0049(10) 0.0045(10) -0.0027(9) C31 0.0227(12) 0.0235(12) 0.0195(12) -0.0011(10) -0.0010(10) 0.0050(9) C32 0.0221(12) 0.0155(11) 0.0181(11) 0.0006(9) 0.0031(9) 0.0010(9) O33 0.0251(8) 0.0187(8) 0.0162(8) 0.0041(6) 0.0046(7) -0.0028(6) O34 0.0166(8) 0.0248(8) 0.0140(8) -0.0046(6) 0.0004(6) -0.0050(6) C35 0.0183(12) 0.0304(13) 0.0196(12) -0.0042(10) 0.0007(9) -0.0070(9) O36 0.0293(9) 0.0288(9) 0.0249(9) 0.0012(7) -0.0031(7) -0.0049(7) C37 0.0328(14) 0.0255(13) 0.0355(14) -0.0026(11) 0.0056(11) -0.0103(11) _geom_special_details ; All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_site_symmetry_2 _geom_bond_distance _geom_bond_publ_flag C1 O22 . 1.469(2) ? C1 C14 . 1.512(3) ? C1 C15 . 1.535(3) ? C1 C2 . 1.550(3) ? C2 O20 . 1.452(2) ? C2 C3 . 1.534(3) ? C2 H2 . 0.98 ? C3 C4 . 1.528(3) ? C3 C8 . 1.547(3) ? C3 H3 . 0.98 ? C4 O34 . 1.435(2) ? C4 C5 . 1.522(3) ? C4 H4 . 0.98 ? C5 C6 . 1.522(3) ? C5 H5A . 0.97 ? C5 H5B . 0.97 ? C6 C7 . 1.511(3) ? C6 H6A . 0.97 ? C6 H6B . 0.97 ? C7 O24 . 1.464(2) ? C7 C8 . 1.548(3) ? C7 H7 . 0.98 ? C8 C19 . 1.535(3) ? C8 C9 . 1.561(3) ? C9 C10 . 1.556(3) ? C9 H9B . 0.97 ? C9 H9A . 0.97 ? C10 O33 . 1.422(2) ? C10 C11 . 1.584(3) ? C10 H10 . 0.98 ? C11 C12 . 1.515(3) ? C11 C15 . 1.571(3) ? C11 H11 . 0.98 ? C12 C13 . 1.328(3) ? C12 C18 . 1.507(3) ? C13 C14 . 1.498(3) ? C13 H13 . 0.93 ? C14 H14A . 0.97 ? C14 H14B . 0.97 ? C15 C16 . 1.533(3) ? C15 C17 . 1.536(3) ? C16 H16B . 0.96 ? C16 H16C . 0.96 ? C16 H16A . 0.96 ? C17 H17A . 0.96 ? C17 H17B . 0.96 ? C17 H17C . 0.96 ? C18 H18B . 0.96 ? C18 H18C . 0.96 ? C18 H18A . 0.96 ? C19 H19C . 0.96 ? C19 H19A . 0.96 ? C19 H19B . 0.96 ? O20 C21 . 1.325(2) ? C21 O23 . 1.203(2) ? C21 O22 . 1.337(2) ? O24 C25 . 1.342(2) ? C25 O26 . 1.210(2) ? C25 C27 . 1.482(3) ? C27 C32 . 1.389(3) ? C27 C28 . 1.395(3) ? C28 C29 . 1.384(3) ? C28 H28 . 0.93 ? C29 C30 . 1.382(3) ? C29 H29 . 0.93 ? C30 C31 . 1.379(3) ? C30 H30 . 0.93 ? C31 C32 . 1.384(3) ? C31 H31 . 0.93 ? C32 H32 . 0.93 ? O33 H33 . 0.82 ? O34 C35 . 1.419(2) ? C35 O36 . 1.368(2) ? C35 H35A . 0.97 ? C35 H35B . 0.97 ? O36 C37 . 1.437(3) ? C37 H37C . 0.96 ? C37 H37A . 0.96 ? C37 H37B . 0.96 ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle _geom_angle_publ_flag O22 C1 C14 . . 106.84(15) ? O22 C1 C15 . . 110.43(15) ? C14 C1 C15 . . 111.48(16) ? O22 C1 C2 . . 101.84(15) ? C14 C1 C2 . . 116.66(16) ? C15 C1 C2 . . 109.08(15) ? O20 C2 C3 . . 111.43(15) ? O20 C2 C1 . . 104.36(14) ? C3 C2 C1 . . 119.49(16) ? O20 C2 H2 . . 107.0 ? C3 C2 H2 . . 107.0 ? C1 C2 H2 . . 107.0 ? C4 C3 C2 . . 112.93(16) ? C4 C3 C8 . . 114.52(15) ? C2 C3 C8 . . 108.22(16) ? C4 C3 H3 . . 106.9 ? C2 C3 H3 . . 106.9 ? C8 C3 H3 . . 106.9 ? O34 C4 C5 . . 110.78(16) ? O34 C4 C3 . . 106.57(15) ? C5 C4 C3 . . 110.44(16) ? O34 C4 H4 . . 109.7 ? C5 C4 H4 . . 109.7 ? C3 C4 H4 . . 109.7 ? C4 C5 C6 . . 110.28(17) ? C4 C5 H5A . . 109.6 ? C6 C5 H5A . . 109.6 ? C4 C5 H5B . . 109.6 ? C6 C5 H5B . . 109.6 ? H5A C5 H5B . . 108.1 ? C7 C6 C5 . . 110.65(16) ? C7 C6 H6A . . 109.5 ? C5 C6 H6A . . 109.5 ? C7 C6 H6B . . 109.5 ? C5 C6 H6B . . 109.5 ? H6A C6 H6B . . 108.1 ? O24 C7 C6 . . 108.86(15) ? O24 C7 C8 . . 106.83(15) ? C6 C7 C8 . . 114.51(17) ? O24 C7 H7 . . 108.8 ? C6 C7 H7 . . 108.8 ? C8 C7 H7 . . 108.8 ? C19 C8 C3 . . 112.46(16) ? C19 C8 C7 . . 109.62(16) ? C3 C8 C7 . . 107.59(15) ? C19 C8 C9 . . 112.39(16) ? C3 C8 C9 . . 109.13(15) ? C7 C8 C9 . . 105.30(16) ? C10 C9 C8 . . 126.80(17) ? C10 C9 H9B . . 105.6 ? C8 C9 H9B . . 105.6 ? C10 C9 H9A . . 105.6 ? C8 C9 H9A . . 105.6 ? H9B C9 H9A . . 106.1 ? O33 C10 C9 . . 113.25(16) ? O33 C10 C11 . . 108.23(15) ? C9 C10 C11 . . 121.68(16) ? O33 C10 H10 . . 103.9 ? C9 C10 H10 . . 103.9 ? C11 C10 H10 . . 103.9 ? C12 C11 C15 . . 110.59(16) ? C12 C11 C10 . . 109.26(16) ? C15 C11 C10 . . 123.08(16) ? C12 C11 H11 . . 104.0 ? C15 C11 H11 . . 104.0 ? C10 C11 H11 . . 104.0 ? C13 C12 C18 . . 121.05(19) ? C13 C12 C11 . . 121.81(19) ? C18 C12 C11 . . 117.12(18) ? C12 C13 C14 . . 124.47(19) ? C12 C13 H13 . . 117.8 ? C14 C13 H13 . . 117.8 ? C13 C14 C1 . . 112.09(16) ? C13 C14 H14A . . 109.2 ? C1 C14 H14A . . 109.2 ? C13 C14 H14B . . 109.2 ? C1 C14 H14B . . 109.2 ? H14A C14 H14B . . 107.9 ? C16 C15 C1 . . 112.24(16) ? C16 C15 C17 . . 105.23(16) ? C1 C15 C17 . . 111.01(16) ? C16 C15 C11 . . 114.78(16) ? C1 C15 C11 . . 106.00(16) ? C17 C15 C11 . . 107.56(16) ? C15 C16 H16B . . 109.5 ? C15 C16 H16C . . 109.5 ? H16B C16 H16C . . 109.5 ? C15 C16 H16A . . 109.5 ? H16B C16 H16A . . 109.5 ? H16C C16 H16A . . 109.5 ? C15 C17 H17A . . 109.5 ? C15 C17 H17B . . 109.5 ? H17A C17 H17B . . 109.5 ? C15 C17 H17C . . 109.5 ? H17A C17 H17C . . 109.5 ? H17B C17 H17C . . 109.5 ? C12 C18 H18B . . 109.5 ? C12 C18 H18C . . 109.5 ? H18B C18 H18C . . 109.5 ? C12 C18 H18A . . 109.5 ? H18B C18 H18A . . 109.5 ? H18C C18 H18A . . 109.5 ? C8 C19 H19C . . 109.5 ? C8 C19 H19A . . 109.5 ? H19C C19 H19A . . 109.5 ? C8 C19 H19B . . 109.5 ? H19C C19 H19B . . 109.5 ? H19A C19 H19B . . 109.5 ? C21 O20 C2 . . 110.43(15) ? O23 C21 O20 . . 123.82(19) ? O23 C21 O22 . . 123.79(18) ? O20 C21 O22 . . 112.39(18) ? C21 O22 C1 . . 110.93(15) ? C25 O24 C7 . . 117.26(15) ? O26 C25 O24 . . 123.40(18) ? O26 C25 C27 . . 124.13(18) ? O24 C25 C27 . . 112.46(17) ? C32 C27 C28 . . 119.50(18) ? C32 C27 C25 . . 117.84(18) ? C28 C27 C25 . . 122.63(18) ? C29 C28 C27 . . 119.61(19) ? C29 C28 H28 . . 120.2 ? C27 C28 H28 . . 120.2 ? C30 C29 C28 . . 120.3(2) ? C30 C29 H29 . . 119.8 ? C28 C29 H29 . . 119.8 ? C31 C30 C29 . . 120.4(2) ? C31 C30 H30 . . 119.8 ? C29 C30 H30 . . 119.8 ? C30 C31 C32 . . 119.6(2) ? C30 C31 H31 . . 120.2 ? C32 C31 H31 . . 120.2 ? C31 C32 C27 . . 120.6(2) ? C31 C32 H32 . . 119.7 ? C27 C32 H32 . . 119.7 ? C10 O33 H33 . . 109.5 ? C35 O34 C4 . . 113.70(14) ? O36 C35 O34 . . 109.31(16) ? O36 C35 H35A . . 109.8 ? O34 C35 H35A . . 109.8 ? O36 C35 H35B . . 109.8 ? O34 C35 H35B . . 109.8 ? H35A C35 H35B . . 108.3 ? C35 O36 C37 . . 112.38(17) ? O36 C37 H37C . . 109.5 ? O36 C37 H37A . . 109.5 ? H37C C37 H37A . . 109.5 ? O36 C37 H37B . . 109.5 ? H37C C37 H37B . . 109.5 ? H37A C37 H37B . . 109.5 ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion _geom_torsion_publ_flag O22 C1 C2 O20 . . . . 1.49(18) ? C14 C1 C2 O20 . . . . -114.39(18) ? C15 C1 C2 O20 . . . . 118.23(16) ? O22 C1 C2 C3 . . . . 126.81(17) ? C14 C1 C2 C3 . . . . 10.9(3) ? C15 C1 C2 C3 . . . . -116.45(19) ? O20 C2 C3 C4 . . . . 15.6(2) ? C1 C2 C3 C4 . . . . -106.25(19) ? O20 C2 C3 C8 . . . . -112.22(17) ? C1 C2 C3 C8 . . . . 125.90(18) ? C2 C3 C4 O34 . . . . 59.3(2) ? C8 C3 C4 O34 . . . . -176.20(15) ? C2 C3 C4 C5 . . . . 179.71(16) ? C8 C3 C4 C5 . . . . -55.8(2) ? O34 C4 C5 C6 . . . . 174.93(15) ? C3 C4 C5 C6 . . . . 57.1(2) ? C4 C5 C6 C7 . . . . -57.8(2) ? C5 C6 C7 O24 . . . . 176.31(15) ? C5 C6 C7 C8 . . . . 56.8(2) ? C4 C3 C8 C19 . . . . -69.6(2) ? C2 C3 C8 C19 . . . . 57.3(2) ? C4 C3 C8 C7 . . . . 51.2(2) ? C2 C3 C8 C7 . . . . 178.13(15) ? C4 C3 C8 C9 . . . . 164.96(16) ? C2 C3 C8 C9 . . . . -68.11(19) ? O24 C7 C8 C19 . . . . -49.8(2) ? C6 C7 C8 C19 . . . . 70.8(2) ? O24 C7 C8 C3 . . . . -172.37(14) ? C6 C7 C8 C3 . . . . -51.8(2) ? O24 C7 C8 C9 . . . . 71.32(18) ? C6 C7 C8 C9 . . . . -168.07(16) ? C19 C8 C9 C10 . . . . -65.5(2) ? C3 C8 C9 C10 . . . . 60.0(2) ? C7 C8 C9 C10 . . . . 175.21(18) ? C8 C9 C10 O33 . . . . 52.8(3) ? C8 C9 C10 C11 . . . . -78.9(3) ? O33 C10 C11 C12 . . . . -169.30(16) ? C9 C10 C11 C12 . . . . -35.5(2) ? O33 C10 C11 C15 . . . . -37.1(2) ? C9 C10 C11 C15 . . . . 96.7(2) ? C15 C11 C12 C13 . . . . -23.7(3) ? C10 C11 C12 C13 . . . . 114.8(2) ? C15 C11 C12 C18 . . . . 154.73(17) ? C10 C11 C12 C18 . . . . -66.8(2) ? C18 C12 C13 C14 . . . . -177.43(18) ? C11 C12 C13 C14 . . . . 1.0(3) ? C12 C13 C14 C1 . . . . -10.5(3) ? O22 C1 C14 C13 . . . . 164.37(15) ? C15 C1 C14 C13 . . . . 43.6(2) ? C2 C1 C14 C13 . . . . -82.6(2) ? O22 C1 C15 C16 . . . . 50.0(2) ? C14 C1 C15 C16 . . . . 168.56(16) ? C2 C1 C15 C16 . . . . -61.2(2) ? O22 C1 C15 C17 . . . . -67.5(2) ? C14 C1 C15 C17 . . . . 51.1(2) ? C2 C1 C15 C17 . . . . -178.64(16) ? O22 C1 C15 C11 . . . . 176.00(14) ? C14 C1 C15 C11 . . . . -65.40(19) ? C2 C1 C15 C11 . . . . 64.86(19) ? C12 C11 C15 C16 . . . . 178.07(16) ? C10 C11 C15 C16 . . . . 46.4(3) ? C12 C11 C15 C1 . . . . 53.6(2) ? C10 C11 C15 C1 . . . . -78.1(2) ? C12 C11 C15 C17 . . . . -65.2(2) ? C10 C11 C15 C17 . . . . 163.09(17) ? C3 C2 O20 C21 . . . . -130.71(17) ? C1 C2 O20 C21 . . . . -0.4(2) ? C2 O20 C21 O23 . . . . 179.11(19) ? C2 O20 C21 O22 . . . . -1.0(2) ? O23 C21 O22 C1 . . . . -178.01(19) ? O20 C21 O22 C1 . . . . 2.1(2) ? C14 C1 O22 C21 . . . . 120.70(17) ? C15 C1 O22 C21 . . . . -117.90(17) ? C2 C1 O22 C21 . . . . -2.14(19) ? C6 C7 O24 C25 . . . . 83.5(2) ? C8 C7 O24 C25 . . . . -152.31(16) ? C7 O24 C25 O26 . . . . 2.0(3) ? C7 O24 C25 C27 . . . . -178.54(15) ? O26 C25 C27 C32 . . . . 10.3(3) ? O24 C25 C27 C32 . . . . -169.09(17) ? O26 C25 C27 C28 . . . . -171.9(2) ? O24 C25 C27 C28 . . . . 8.7(3) ? C32 C27 C28 C29 . . . . 0.0(3) ? C25 C27 C28 C29 . . . . -177.76(19) ? C27 C28 C29 C30 . . . . 0.1(3) ? C28 C29 C30 C31 . . . . -0.4(3) ? C29 C30 C31 C32 . . . . 0.6(3) ? C30 C31 C32 C27 . . . . -0.6(3) ? C28 C27 C32 C31 . . . . 0.3(3) ? C25 C27 C32 C31 . . . . 178.12(18) ? C5 C4 O34 C35 . . . . 88.2(2) ? C3 C4 O34 C35 . . . . -151.61(17) ? C4 O34 C35 O36 . . . . -177.35(16) ? O34 C35 O36 C37 . . . . 72.7(2) ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_site_symmetry_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_publ_flag C2 H2 O33 . 0.98 2.27 3.200(2) 157 yes C14 H14A O34 . 0.97 2.47 3.293(2) 142 yes O33 H33 O23 4_666 0.82 1.96 2.7823(19) 179 yes C7 H7 O26 3_757 0.98 2.50 3.353(2) 145 yes C16 H16A Cg2 4_454 0.98 2.93 3.594(2) 128 yes _shelx_res_checksum 15137 _iucr_refine_instructions_details ; TITL mo_141219Oishi_0ma in P2(1)/n CELL 0.71073 9.3612 19.6336 14.1965 90.000 101.762 90.000 ZERR 4 0.0006 0.0015 0.0009 0.000 0.002 0.000 LATT 1 SYMM 0.5-X, 0.5+Y, 0.5-Z SFAC C H O UNIT 116 152 32 OMIT -1 0 1 L.S. 4 ACTA 50 SHEL 20 0.84 BOND $H FMAP 2 PLAN 5 CONF HTAB C14 O34 HTAB C2 O33 EQIV $7 x+1/2, -y+1/2, z+1/2 EQIV $8 -x+2, -y, -z+2 EQIV $9 x-1/2, -y+1/2, z-1/2 HTAB O33 O23_$7 HTAB C7 O26_$8 HTAB C5 O26_$8 RTAB d2cg C16 C27_$9 C28_$9 C29_$9 C30_$9 C31_$9 C32_$9 RTAB d2cg H16A C27_$9 C28_$9 C29_$9 C30_$9 C31_$9 C32_$9 MPLA 5 C1 C2 O20 C21 O22 MPLA 4 C2 O20 C21 O22 C1 MPLA 4 C1 C2 O20 C21 O22 MPLA 4 C14 C13 C12 C11 C15 C1 SIZE 0.140 0.230 0.230 TEMP 23.000 WGHT 0.054000 1.075200 FVAR 0.13796 MOLE 1 C1 1 0.716911 0.186539 0.686185 11.00000 0.01386 0.01763 = 0.00958 0.00031 -0.00173 0.00003 C2 1 0.654386 0.172594 0.777379 11.00000 0.00923 0.01822 = 0.01262 -0.00055 0.00030 0.00049 AFIX 13 H2 2 0.678195 0.212282 0.819520 11.00000 -1.20000 AFIX 0 C3 1 0.704711 0.109347 0.838696 11.00000 0.01158 0.01559 = 0.01261 -0.00028 0.00388 0.00141 AFIX 13 H3 2 0.788405 0.090507 0.815780 11.00000 -1.20000 AFIX 0 C4 1 0.588781 0.053497 0.826915 11.00000 0.01537 0.02035 = 0.01145 -0.00382 0.00265 -0.00135 AFIX 13 H4 2 0.500490 0.071104 0.845441 11.00000 -1.20000 AFIX 0 C5 1 0.645307 -0.007844 0.888956 11.00000 0.01875 0.01466 = 0.02157 -0.00181 0.00597 -0.00400 AFIX 23 H5A 2 0.727941 -0.027482 0.867121 11.00000 -1.20000 H5B 2 0.569454 -0.042182 0.882715 11.00000 -1.20000 AFIX 0 C6 1 0.691473 0.013299 0.993914 11.00000 0.02178 0.01905 = 0.01738 0.00412 0.00517 -0.00082 AFIX 23 H6A 2 0.607313 0.030114 1.016895 11.00000 -1.20000 H6B 2 0.729496 -0.025955 1.032475 11.00000 -1.20000 AFIX 0 C7 1 0.806944 0.068159 1.005231 11.00000 0.01917 0.01840 = 0.00910 -0.00031 0.00300 0.00179 AFIX 13 H7 2 0.895227 0.049127 0.988384 11.00000 -1.20000 AFIX 0 C8 1 0.761492 0.132681 0.943724 11.00000 0.01322 0.01417 = 0.01291 -0.00074 0.00251 0.00032 C9 1 0.905146 0.174248 0.949388 11.00000 0.01666 0.01742 = 0.01334 -0.00125 -0.00094 0.00096 AFIX 23 H9B 2 0.939321 0.184763 1.016993 11.00000 -1.20000 H9A 2 0.975188 0.142437 0.932565 11.00000 -1.20000 AFIX 0 C10 1 0.923783 0.241121 0.894358 11.00000 0.01544 0.01705 = 0.01622 -0.00246 0.00101 -0.00024 AFIX 13 H10 2 1.018102 0.259045 0.928094 11.00000 -1.20000 AFIX 0 C11 1 0.936958 0.240487 0.784906 11.00000 0.01533 0.01850 = 0.01792 -0.00104 0.00389 -0.00388 AFIX 13 H11 2 1.003626 0.278213 0.780053 11.00000 -1.20000 AFIX 0 C12 1 1.020806 0.177756 0.765708 11.00000 0.01600 0.02050 = 0.01699 -0.00043 0.00670 -0.00062 C13 1 0.958826 0.128651 0.706992 11.00000 0.01760 0.01782 = 0.01619 0.00147 0.00706 0.00304 AFIX 43 H13 2 1.015617 0.091081 0.698887 11.00000 -1.20000 AFIX 0 C14 1 0.803704 0.129641 0.652928 11.00000 0.01997 0.01557 = 0.01182 -0.00007 0.00588 0.00011 AFIX 23 H14A 2 0.758134 0.086366 0.661678 11.00000 -1.20000 H14B 2 0.802086 0.135141 0.584817 11.00000 -1.20000 AFIX 0 C15 1 0.803744 0.253381 0.699725 11.00000 0.01703 0.01526 = 0.01413 0.00054 0.00402 -0.00005 C16 1 0.708373 0.314550 0.713596 11.00000 0.02174 0.01879 = 0.01523 0.00275 0.00026 0.00281 AFIX 137 H16B 2 0.644715 0.325483 0.653509 11.00000 -1.50000 H16C 2 0.769512 0.352996 0.735521 11.00000 -1.50000 H16A 2 0.651166 0.303477 0.760445 11.00000 -1.50000 AFIX 0 C17 1 0.864951 0.270297 0.609966 11.00000 0.02480 0.01866 = 0.02065 0.00091 0.00793 -0.00295 AFIX 137 H17A 2 0.937723 0.237303 0.602904 11.00000 -1.50000 H17B 2 0.908004 0.314866 0.616784 11.00000 -1.50000 H17C 2 0.787376 0.269293 0.554119 11.00000 -1.50000 AFIX 0 C18 1 1.179626 0.174068 0.814211 11.00000 0.01842 0.02818 = 0.02625 -0.00485 0.00522 0.00045 AFIX 137 H18B 2 1.219316 0.131131 0.799796 11.00000 -1.50000 H18C 2 1.188707 0.178318 0.882543 11.00000 -1.50000 H18A 2 1.231997 0.210407 0.791184 11.00000 -1.50000 AFIX 0 C19 1 0.646122 0.172238 0.984316 11.00000 0.01993 0.01875 = 0.01400 0.00031 0.00324 0.00159 AFIX 137 H19C 2 0.614944 0.211120 0.944402 11.00000 -1.50000 H19A 2 0.687313 0.187121 1.048522 11.00000 -1.50000 H19B 2 0.563942 0.143218 0.985415 11.00000 -1.50000 AFIX 0 O20 3 0.497325 0.172778 0.743032 11.00000 0.01369 0.02645 = 0.01190 0.00318 0.00114 0.00361 C21 1 0.464568 0.184886 0.649271 11.00000 0.01949 0.01734 = 0.01674 0.00184 0.00411 -0.00030 O22 3 0.583268 0.194625 0.612134 11.00000 0.01516 0.02252 = 0.01237 0.00237 0.00074 0.00004 O23 3 0.341900 0.186959 0.602806 11.00000 0.01566 0.03753 = 0.01894 0.00771 -0.00141 0.00075 O24 3 0.841157 0.090124 1.105833 11.00000 0.01974 0.01970 = 0.01006 0.00042 0.00115 0.00426 C25 1 0.938053 0.052743 1.167311 11.00000 0.01592 0.01494 = 0.01544 0.00340 0.00334 -0.00050 O26 3 1.000069 0.003706 1.143109 11.00000 0.02951 0.02250 = 0.01787 -0.00042 0.00226 0.01017 C27 1 0.961190 0.078731 1.267312 11.00000 0.01728 0.01388 = 0.01518 0.00238 0.00416 -0.00237 C28 1 0.875353 0.130064 1.295082 11.00000 0.01754 0.02418 = 0.01578 0.00182 0.00210 0.00223 AFIX 43 H28 2 0.797873 0.148376 1.250782 11.00000 -1.20000 AFIX 0 C29 1 0.906181 0.153580 1.388957 11.00000 0.02410 0.03168 = 0.02032 -0.00270 0.00596 0.00706 AFIX 43 H29 2 0.849130 0.187765 1.407743 11.00000 -1.20000 AFIX 0 C30 1 1.021360 0.126497 1.454912 11.00000 0.02677 0.02931 = 0.01346 -0.00267 0.00447 -0.00495 AFIX 43 H30 2 1.041700 0.142750 1.517761 11.00000 -1.20000 AFIX 0 C31 1 1.106323 0.075521 1.428116 11.00000 0.02274 0.02350 = 0.01949 0.00498 -0.00099 -0.00105 AFIX 43 H31 2 1.183170 0.057113 1.472830 11.00000 -1.20000 AFIX 0 C32 1 1.076526 0.051937 1.334304 11.00000 0.02214 0.01555 = 0.01812 0.00097 0.00315 0.00056 AFIX 43 H32 2 1.134234 0.017851 1.315959 11.00000 -1.20000 AFIX 0 O33 3 0.822697 0.292776 0.906649 11.00000 0.02507 0.01871 = 0.01625 -0.00283 0.00460 0.00414 AFIX 147 H33 2 0.827121 0.299253 0.964234 11.00000 -1.50000 AFIX 0 O34 3 0.556982 0.035441 0.726901 11.00000 0.01658 0.02483 = 0.01396 -0.00504 0.00042 -0.00462 C35 1 0.412890 0.010808 0.693948 11.00000 0.01831 0.03042 = 0.01963 -0.00698 0.00070 -0.00417 AFIX 23 H35A 2 0.395670 -0.028107 0.732235 11.00000 -1.20000 H35B 2 0.343027 0.046026 0.700748 11.00000 -1.20000 AFIX 0 O36 3 0.395271 -0.007789 0.599392 11.00000 0.02925 0.02879 = 0.02492 -0.00491 -0.00308 0.00120 C37 1 0.471486 -0.069651 0.587149 11.00000 0.03283 0.02549 = 0.03555 -0.01030 0.00559 -0.00261 AFIX 137 H37C 2 0.573858 -0.063679 0.612617 11.00000 -1.50000 H37A 2 0.456571 -0.080543 0.519928 11.00000 -1.50000 H37B 2 0.434944 -0.106058 0.620722 11.00000 -1.50000 AFIX 0 HKLF 4 REM mo_141219Oishi_0ma in P2(1)/n REM R1 = 0.0428 for 3212 Fo > 4sig(Fo) and 0.0733 for all 4480 data REM 340 parameters refined using 0 restraints END WGHT 0.0435 1.4475 REM Highest difference peak 0.511, deepest hole -0.212, 1-sigma level 0.050 Q1 1 0.4464 -0.0588 0.6813 11.00000 0.05 0.51 Q2 1 0.7887 0.1047 0.9778 11.00000 0.05 0.28 Q3 1 0.8265 0.1490 0.9387 11.00000 0.05 0.26 Q4 1 0.7278 0.1230 0.8949 11.00000 0.05 0.26 Q5 1 0.7740 0.2185 0.6966 11.00000 0.05 0.24 ; data_C _database_code_depnum_ccdc_archive 'CCDC 1057985' _chemical_name_systematic ;\ (+-)-(1SR,5SR,6SR,7SR,10SR,11SR,\ 14SR)-7-Methoxymethoxy-11,15,18,18-tetramethyl-3,13-dioxo-2,4-\ dioxatetracyclo[12.3.1.0^1,5^.0^6,11^]octadec-15-en-10-yl benzoate ; _chemical_name_common ? _chemical_formula_moiety 'C29 H36 O8' _chemical_formula_sum 'C29 H36 O8' _chemical_formula_iupac 'C29 H36 O8' _chemical_formula_weight 512.59 _chemical_melting_point 512.2 _space_group_crystal_system monoclinic _space_group_name_H-M_alt 'P 1 21/c 1' _space_group_name_Hall '-P 2ybc' loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y-1/2, z-1/2' _cell_length_a 13.2416(8) _cell_length_b 13.1779(8) _cell_length_c 15.2428(8) _cell_angle_alpha 90 _cell_angle_beta 109.387(2) _cell_angle_gamma 90 _cell_volume 2509.0(3) _cell_formula_units_Z 4 _cell_measurement_reflns_used 6186 _cell_measurement_theta_min 2.83 _cell_measurement_theta_max 24.92 _cell_measurement_temperature 90.0 _exptl_crystal_description plate _exptl_crystal_colour colorless _exptl_crystal_size_max 0.220 _exptl_crystal_size_mid 0.140 _exptl_crystal_size_min 0.090 _exptl_crystal_density_diffrn 1.357 _exptl_crystal_density_meas ? _exptl_crystal_density_method 'not measured' _exptl_crystal_F_000 1096 _exptl_absorpt_coefficient_mu 0.098 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details ; (SADABS; Bruker, 2014) ; _exptl_absorpt_correction_T_min 0.92 _exptl_absorpt_correction_T_max 0.99 _exptl_special_details ; M.p. 510.7--512.2 K (not corrected); IR (film) 2934, 1804, 1718, 1689, 1668, 1272, 1230, 1108, 1058, 732, 713 cm^-1^; ^1^H NMR (500 MHz, CDCl~3~) \d (p.p.m.) 8.05--8.98 (m, 2H), 7.62--7.56 (m, 1H), 7.49--7.43 (m, 2H), 5.73 (bs, 1H), 4.79 (d, J = 6.9 Hz, 1H), 4.76 (dd, J = 11.0, 4.0 Hz, 1H), 4.60 (d, J = 6.9 Hz, 1H), 4.22 (d, J = 3.4 Hz, 1H), 3.62 (ddd, J = 10.6, 10.3, 5.2 Hz, 1H), 3.37 (s, 3H), 3.00 (bd, J = 17.0 Hz, 1H), 2.61 (d, J = 10.9 Hz, 1H), 2.51 (d, J = 17.0 Hz, 1H), 2.47 (s, 1H), 2.42--2.35 (m, 1H), 2.33 (dd, J = 10.6, 3.4 Hz, 1H), 2.13 (d, J = 10.9 Hz, 1H), 1.95--1.88 (m, 1H), 1.71 (s, 3H), 1.71--1.52 (m, 2H), 1.27 (s, 3H), 1.17 (s, 3H), 1.16 (s, 3H); ^13^C NMR (125 MHz, CDCl~3~) \d (p.p.m.) 211.2 (C), 165.9 (C), 153.7 (C), 135.8 (C), 133.5 (CH), 129.8 (C), 129.7 (CH), 128.7 (CH), 122.6 (CH), 97.8 (CH~2~), 87.0 (C), 79.3 (CH), 79.0 (CH), 74.7 (CH), 65.7 (CH), 56.0 (CH~3~), 51.2 (CH~2~), 48.0 (CH), 47.1 (C), 44.1 (C), 31.9 (CH~2~), 31.2 (CH~2~), 25.1 (CH~3~), 24.6 (CH~3~), 24.6 (CH~2~), 19.3 (CH~3~), 12.3 (CH~3~); LRMS (EI) m/z 512 (M^+^, 5%), 346 (9), 302 (7), 121 (28), 105 (100), 77 (55); HRMS (EI) m/z calcd for C~29~H~36~O~8~^+^ [M]^+^ 512.2410, found 514.2408. ; _diffrn_ambient_temperature 90.0 _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_radiation_monochromator 'multilayered confocal mirror' _diffrn_measurement_device_type 'Bruker D8 Venture' _diffrn_measurement_method '\f and \w scans' _diffrn_detector_area_resol_mean 8.333 _diffrn_reflns_number 22512 _diffrn_reflns_av_R_equivalents 0.0627 _diffrn_reflns_av_sigmaI/netI ? _diffrn_reflns_theta_min 2.35 _diffrn_reflns_theta_max 25.02 _diffrn_reflns_theta_full 25.02 _diffrn_measured_fraction_theta_max 0.991 _diffrn_measured_fraction_theta_full 0.991 _diffrn_reflns_limit_h_min -15 _diffrn_reflns_limit_h_max 14 _diffrn_reflns_limit_k_min -15 _diffrn_reflns_limit_k_max 15 _diffrn_reflns_limit_l_min -16 _diffrn_reflns_limit_l_max 18 _diffrn_standards_number 0 _diffrn_standards_interval_count ? _diffrn_standards_decay_% ? _refine_special_details ; Refinement of F^2^ against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F^2^, conventional R-factors R are based on F, with F set to zero for negative F^2^. The threshold expression of F^2^ > \s(F^2^) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F^2^ are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. Problematic two reflections with |I(obs)-I(calc)|/\sW(I) greater than 10 (1 1 0 and 11 4 3) have been omitted in the final refinement. ; _reflns_number_total 4395 _reflns_number_gt 3050 _reflns_threshold_expression 'I > 2\s(I)' _refine_ls_structure_factor_coef Fsqd _refine_ls_matrix_type full _refine_ls_R_factor_all 0.0832 _refine_ls_R_factor_gt 0.0439 _refine_ls_wR_factor_gt 0.0884 _refine_ls_wR_factor_ref 0.1050 _refine_ls_goodness_of_fit_ref 0.962 _refine_ls_restrained_S_all 0.962 _refine_ls_number_reflns 4395 _refine_ls_number_parameters 339 _refine_ls_number_restraints 0 _refine_ls_number_constraints ? _refine_ls_hydrogen_treatment constr _refine_ls_weighting_scheme calc _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0391P)^2^+2.2049P] where P=(Fo^2^+2Fc^2^)/3' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary difmap _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_diff_density_max 0.288 _refine_diff_density_min -0.245 _refine_ls_extinction_method none _refine_ls_extinction_coef ? loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' _computing_data_collection ; APEX2 (Bruker, 2014) ; _computing_cell_refinement ; SAINT (Bruker, 2014) ; _computing_data_reduction ; SAINT (Bruker, 2014) ; _computing_structure_solution ; SHELXS2013 (Sheldrick, 2008) ; _computing_structure_refinement ; SHELXL2014 (Sheldrick, 2015) ; _computing_molecular_graphics ; Mercury (Macrae et al., 2006) ; _computing_publication_material ; publCif (Westrip, 2010) and PLATON (Spek, 2009) ; loop_ _atom_site_type_symbol _atom_site_label _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_calc_flag _atom_site_occupancy _atom_site_disorder_assembly _atom_site_disorder_group C C1 0.81842(17) 0.32712(17) 0.49210(14) 0.0156(5) Uani d 1 . . C C2 0.83265(18) 0.43504(17) 0.53612(14) 0.0157(5) Uani d 1 . . H H2 0.8939 0.4312 0.5959 0.019 Uiso calc 1 . . C C3 0.73832(17) 0.48566(16) 0.55835(14) 0.0141(5) Uani d 1 . . H H3 0.6787 0.435 0.5422 0.017 Uiso calc 1 . . C C4 0.69530(17) 0.58009(17) 0.49830(14) 0.0151(5) Uani d 1 . . H H4 0.7551 0.629 0.5048 0.018 Uiso calc 1 . . C C5 0.60735(18) 0.63170(17) 0.52421(14) 0.0186(5) Uani d 1 . . H H5A 0.543 0.5879 0.5055 0.022 Uiso calc 1 . . H H5B 0.5884 0.6962 0.4894 0.022 Uiso calc 1 . . C C6 0.63941(18) 0.65384(17) 0.62826(14) 0.0191(5) Uani d 1 . . H H6A 0.699 0.7034 0.6466 0.023 Uiso calc 1 . . H H6B 0.578 0.6834 0.6427 0.023 Uiso calc 1 . . C C7 0.67390(18) 0.55614(17) 0.68165(13) 0.0152(5) Uani d 1 . . H H7 0.6122 0.5078 0.6641 0.018 Uiso calc 1 . . C C8 0.77033(17) 0.50500(16) 0.66456(14) 0.0144(5) Uani d 1 . . C C9 0.78727(18) 0.40213(17) 0.71791(14) 0.0170(5) Uani d 1 . . H H9B 0.8022 0.4176 0.7846 0.02 Uiso calc 1 . . H H9A 0.7185 0.3648 0.6963 0.02 Uiso calc 1 . . C C10 0.87422(19) 0.33035(17) 0.71100(14) 0.0176(5) Uani d 1 . . C C11 0.84777(17) 0.23989(17) 0.64233(14) 0.0169(5) Uani d 1 . . H H11 0.8853 0.1799 0.6791 0.02 Uiso calc 1 . . C C12 0.72983(18) 0.21357(17) 0.60918(15) 0.0170(5) Uani d 1 . . C C13 0.66633(18) 0.23789(17) 0.52443(15) 0.0179(5) Uani d 1 . . H H13 0.5922 0.2228 0.5084 0.021 Uiso calc 1 . . C C14 0.70379(17) 0.28774(17) 0.45229(14) 0.0175(5) Uani d 1 . . H H14A 0.6555 0.3451 0.4243 0.021 Uiso calc 1 . . H H14B 0.6994 0.2383 0.4023 0.021 Uiso calc 1 . . C C15 0.89166(17) 0.24989(17) 0.55936(14) 0.0177(5) Uani d 1 . . C C16 1.00975(18) 0.28215(18) 0.59015(16) 0.0209(5) Uani d 1 . . H H16A 1.0171 0.3507 0.6165 0.031 Uiso calc 1 . . H H16B 1.0346 0.2816 0.5363 0.031 Uiso calc 1 . . H H16C 1.0528 0.2347 0.6373 0.031 Uiso calc 1 . . C C17 0.88509(19) 0.14530(17) 0.51289(16) 0.0221(6) Uani d 1 . . H H17C 0.9039 0.152 0.4562 0.033 Uiso calc 1 . . H H17A 0.8121 0.1188 0.497 0.033 Uiso calc 1 . . H H17B 0.9351 0.0985 0.5559 0.033 Uiso calc 1 . . C C18 0.69208(19) 0.15857(18) 0.67848(15) 0.0222(6) Uani d 1 . . H H18B 0.6144 0.1488 0.6528 0.033 Uiso calc 1 . . H H18C 0.7096 0.1985 0.7358 0.033 Uiso calc 1 . . H H18A 0.7275 0.0924 0.6922 0.033 Uiso calc 1 . . C C19 0.87058(18) 0.57156(17) 0.70192(15) 0.0186(5) Uani d 1 . . H H19A 0.8809 0.5905 0.7665 0.028 Uiso calc 1 . . H H19B 0.8617 0.633 0.6639 0.028 Uiso calc 1 . . H H19C 0.9332 0.5337 0.6992 0.028 Uiso calc 1 . . O O20 0.86805(11) 0.49630(11) 0.47260(9) 0.0165(4) Uani d 1 . . C C21 0.87791(17) 0.43902(18) 0.40303(15) 0.0169(5) Uani d 1 . . O O22 0.85523(12) 0.34137(12) 0.41269(10) 0.0187(4) Uani d 1 . . O O23 0.90357(12) 0.47131(12) 0.34036(10) 0.0224(4) Uani d 1 . . O O24 0.70651(11) 0.57550(11) 0.78110(9) 0.0170(4) Uani d 1 . . C C25 0.63110(18) 0.57567(16) 0.82216(15) 0.0146(5) Uani d 1 . . O O26 0.53686(12) 0.56418(12) 0.78106(10) 0.0203(4) Uani d 1 . . C C27 0.67949(18) 0.58868(16) 0.92408(14) 0.0150(5) Uani d 1 . . C C28 0.61586(19) 0.57355(17) 0.97941(15) 0.0212(5) Uani d 1 . . H H28 0.5422 0.5574 0.9515 0.025 Uiso calc 1 . . C C29 0.6597(2) 0.58201(18) 1.07519(15) 0.0237(6) Uani d 1 . . H H29 0.6161 0.5712 1.1128 0.028 Uiso calc 1 . . C C30 0.7661(2) 0.60592(18) 1.11608(16) 0.0255(6) Uani d 1 . . H H30 0.796 0.6109 1.1818 0.031 Uiso calc 1 . . C C31 0.8296(2) 0.62271(18) 1.06145(16) 0.0250(6) Uani d 1 . . H H31 0.9028 0.6403 1.0896 0.03 Uiso calc 1 . . C C32 0.78646(19) 0.61393(18) 0.96603(15) 0.0215(5) Uani d 1 . . H H32 0.8304 0.6253 0.9288 0.026 Uiso calc 1 . . O O33 0.96560(13) 0.34029(12) 0.76362(10) 0.0236(4) Uani d 1 . . O O34 0.65380(12) 0.54447(11) 0.40409(9) 0.0182(4) Uani d 1 . . C C35 0.67590(19) 0.60542(18) 0.33721(15) 0.0214(6) Uani d 1 . . H H35A 0.7532 0.6218 0.3592 0.026 Uiso calc 1 . . H H35B 0.6603 0.566 0.2789 0.026 Uiso calc 1 . . O O36 0.61766(12) 0.69614(11) 0.31770(10) 0.0200(4) Uani d 1 . . C C37 0.50654(18) 0.68122(18) 0.27053(16) 0.0243(6) Uani d 1 . . H H37B 0.4746 0.647 0.312 0.036 Uiso calc 1 . . H H37C 0.4967 0.6393 0.2152 0.036 Uiso calc 1 . . H H37A 0.4717 0.7471 0.2518 0.036 Uiso calc 1 . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_12 _atom_site_aniso_U_13 _atom_site_aniso_U_23 C1 0.0189(13) 0.0175(13) 0.0133(11) 0.0015(10) 0.0092(10) -0.0016(9) C2 0.0189(13) 0.0148(13) 0.0149(11) -0.0009(10) 0.0079(10) 0.0026(9) C3 0.0149(12) 0.0126(12) 0.0152(11) -0.0002(10) 0.0056(9) -0.0016(9) C4 0.0166(12) 0.0147(13) 0.0130(11) -0.0004(10) 0.0037(10) -0.0012(9) C5 0.0216(13) 0.0163(13) 0.0183(11) 0.0057(10) 0.0071(10) 0.0028(10) C6 0.0228(13) 0.0159(13) 0.0212(12) 0.0041(10) 0.0109(10) -0.0006(10) C7 0.0192(12) 0.0160(13) 0.0112(11) -0.0035(10) 0.0061(10) -0.0036(9) C8 0.0154(12) 0.0156(13) 0.0129(11) -0.0015(10) 0.0058(9) -0.0010(9) C9 0.0199(13) 0.0170(13) 0.0150(11) 0.0001(10) 0.0070(10) -0.0003(9) C10 0.0209(14) 0.0182(13) 0.0137(11) -0.0007(11) 0.0055(11) 0.0052(10) C11 0.0187(13) 0.0134(13) 0.0178(11) 0.0010(10) 0.0049(10) 0.0024(9) C12 0.0197(13) 0.0128(13) 0.0201(12) -0.0010(10) 0.0089(10) -0.0034(10) C13 0.0180(13) 0.0132(13) 0.0226(12) -0.0012(10) 0.0070(10) -0.0040(10) C14 0.0192(13) 0.0151(13) 0.0154(11) 0.0009(10) 0.0021(10) -0.0013(9) C15 0.0191(13) 0.0144(13) 0.0197(12) 0.0023(10) 0.0066(10) -0.0003(10) C16 0.0204(13) 0.0179(14) 0.0257(12) 0.0051(10) 0.0094(10) 0.0026(10) C17 0.0260(14) 0.0167(14) 0.0252(12) 0.0024(11) 0.0106(11) -0.0014(10) C18 0.0242(14) 0.0209(14) 0.0229(12) -0.0011(11) 0.0096(11) -0.0002(10) C19 0.0205(13) 0.0180(13) 0.0181(11) -0.0001(10) 0.0074(10) -0.0028(10) O20 0.0199(9) 0.0152(9) 0.0177(8) -0.0015(7) 0.0109(7) -0.0013(7) C21 0.0127(12) 0.0184(14) 0.0175(12) 0.0024(10) 0.0022(10) -0.0007(10) O22 0.0258(9) 0.0165(9) 0.0177(8) -0.0001(7) 0.0122(7) -0.0014(7) O23 0.0254(9) 0.0267(10) 0.0201(8) -0.0039(8) 0.0139(7) 0.0004(7) O24 0.0194(9) 0.0194(9) 0.0139(7) -0.0010(7) 0.0079(7) -0.0032(6) C25 0.0171(13) 0.0079(12) 0.0222(12) 0.0014(10) 0.0109(11) 0.0004(9) O26 0.0175(10) 0.0225(10) 0.0211(8) -0.0019(7) 0.0066(7) -0.0029(7) C27 0.0199(13) 0.0108(12) 0.0146(11) 0.0022(10) 0.0061(10) 0.0003(9) C28 0.0256(14) 0.0157(13) 0.0235(12) 0.0022(11) 0.0098(11) 0.0009(10) C29 0.0333(16) 0.0241(15) 0.0172(12) 0.0041(12) 0.0129(12) 0.0027(10) C30 0.0390(16) 0.0196(14) 0.0150(12) 0.0049(12) 0.0052(12) 0.0012(10) C31 0.0263(14) 0.0230(15) 0.0220(13) -0.0033(11) 0.0029(11) -0.0035(10) C32 0.0243(14) 0.0214(14) 0.0212(12) -0.0008(11) 0.0106(11) -0.0026(10) O33 0.0205(10) 0.0264(10) 0.0200(8) 0.0017(8) 0.0016(8) -0.0005(7) O34 0.0248(9) 0.0179(9) 0.0124(7) 0.0017(7) 0.0068(7) 0.0018(6) C35 0.0241(14) 0.0254(15) 0.0162(12) 0.0067(11) 0.0087(11) 0.0051(10) O36 0.0203(9) 0.0162(9) 0.0221(8) -0.0005(7) 0.0052(7) 0.0047(7) C37 0.0200(14) 0.0243(15) 0.0275(13) 0.0014(11) 0.0065(11) 0.0056(11) _geom_special_details ; All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. ; loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_site_symmetry_2 _geom_bond_distance _geom_bond_publ_flag C1 O22 . 1.459(2) ? C1 C14 . 1.526(3) ? C1 C15 . 1.539(3) ? C1 C2 . 1.557(3) ? C2 O20 . 1.453(2) ? C2 C3 . 1.550(3) ? C2 H2 . 1.0 ? C3 C4 . 1.538(3) ? C3 C8 . 1.552(3) ? C3 H3 . 1.0 ? C4 O34 . 1.435(2) ? C4 C5 . 1.510(3) ? C4 H4 . 1.0 ? C5 C6 . 1.528(3) ? C5 H5A . 0.99 ? C5 H5B . 0.99 ? C6 C7 . 1.510(3) ? C6 H6A . 0.99 ? C6 H6B . 0.99 ? C7 O24 . 1.454(2) ? C7 C8 . 1.540(3) ? C7 H7 . 1.0 ? C8 C19 . 1.534(3) ? C8 C9 . 1.558(3) ? C9 C10 . 1.521(3) ? C9 H9B . 0.99 ? C9 H9A . 0.99 ? C10 O33 . 1.217(3) ? C10 C11 . 1.548(3) ? C11 C12 . 1.514(3) ? C11 C15 . 1.563(3) ? C11 H11 . 1.0 ? C12 C13 . 1.326(3) ? C12 C18 . 1.497(3) ? C13 C14 . 1.500(3) ? C13 H13 . 0.95 ? C14 H14A . 0.99 ? C14 H14B . 0.99 ? C15 C16 . 1.536(3) ? C15 C17 . 1.539(3) ? C16 H16A . 0.98 ? C16 H16B . 0.98 ? C16 H16C . 0.98 ? C17 H17C . 0.98 ? C17 H17A . 0.98 ? C17 H17B . 0.98 ? C18 H18B . 0.98 ? C18 H18C . 0.98 ? C18 H18A . 0.98 ? C19 H19A . 0.98 ? C19 H19B . 0.98 ? C19 H19C . 0.98 ? O20 C21 . 1.343(3) ? C21 O23 . 1.193(2) ? C21 O22 . 1.341(3) ? O24 C25 . 1.343(2) ? C25 O26 . 1.206(3) ? C25 C27 . 1.481(3) ? C27 C32 . 1.387(3) ? C27 C28 . 1.390(3) ? C28 C29 . 1.385(3) ? C28 H28 . 0.95 ? C29 C30 . 1.374(3) ? C29 H29 . 0.95 ? C30 C31 . 1.384(3) ? C30 H30 . 0.95 ? C31 C32 . 1.380(3) ? C31 H31 . 0.95 ? C32 H32 . 0.95 ? O34 C35 . 1.403(3) ? C35 O36 . 1.400(3) ? C35 H35A . 0.99 ? C35 H35B . 0.99 ? O36 C37 . 1.421(3) ? C37 H37B . 0.98 ? C37 H37C . 0.98 ? C37 H37A . 0.98 ? loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle _geom_angle_publ_flag O22 C1 C14 . . 106.01(16) ? O22 C1 C15 . . 109.12(17) ? C14 C1 C15 . . 111.33(18) ? O22 C1 C2 . . 102.36(16) ? C14 C1 C2 . . 116.36(18) ? C15 C1 C2 . . 110.96(17) ? O20 C2 C3 . . 111.62(17) ? O20 C2 C1 . . 103.89(15) ? C3 C2 C1 . . 119.76(18) ? O20 C2 H2 . . 107.0 ? C3 C2 H2 . . 107.0 ? C1 C2 H2 . . 107.0 ? C4 C3 C2 . . 112.61(17) ? C4 C3 C8 . . 114.01(17) ? C2 C3 C8 . . 109.74(17) ? C4 C3 H3 . . 106.7 ? C2 C3 H3 . . 106.7 ? C8 C3 H3 . . 106.7 ? O34 C4 C5 . . 109.67(17) ? O34 C4 C3 . . 105.90(17) ? C5 C4 C3 . . 111.98(17) ? O34 C4 H4 . . 109.7 ? C5 C4 H4 . . 109.7 ? C3 C4 H4 . . 109.7 ? C4 C5 C6 . . 112.64(18) ? C4 C5 H5A . . 109.1 ? C6 C5 H5A . . 109.1 ? C4 C5 H5B . . 109.1 ? C6 C5 H5B . . 109.1 ? H5A C5 H5B . . 107.8 ? C7 C6 C5 . . 109.07(18) ? C7 C6 H6A . . 109.9 ? C5 C6 H6A . . 109.9 ? C7 C6 H6B . . 109.9 ? C5 C6 H6B . . 109.9 ? H6A C6 H6B . . 108.3 ? O24 C7 C6 . . 110.13(17) ? O24 C7 C8 . . 106.08(16) ? C6 C7 C8 . . 113.65(17) ? O24 C7 H7 . . 109.0 ? C6 C7 H7 . . 109.0 ? C8 C7 H7 . . 109.0 ? C19 C8 C7 . . 110.53(18) ? C19 C8 C3 . . 112.58(17) ? C7 C8 C3 . . 107.06(16) ? C19 C8 C9 . . 110.29(17) ? C7 C8 C9 . . 106.03(17) ? C3 C8 C9 . . 110.09(17) ? C10 C9 C8 . . 119.09(18) ? C10 C9 H9B . . 107.5 ? C8 C9 H9B . . 107.5 ? C10 C9 H9A . . 107.5 ? C8 C9 H9A . . 107.5 ? H9B C9 H9A . . 107.0 ? O33 C10 C9 . . 119.8(2) ? O33 C10 C11 . . 118.8(2) ? C9 C10 C11 . . 121.29(19) ? C12 C11 C10 . . 112.27(18) ? C12 C11 C15 . . 111.64(17) ? C10 C11 C15 . . 114.89(18) ? C12 C11 H11 . . 105.7 ? C10 C11 H11 . . 105.7 ? C15 C11 H11 . . 105.7 ? C13 C12 C18 . . 123.5(2) ? C13 C12 C11 . . 121.4(2) ? C18 C12 C11 . . 115.12(18) ? C12 C13 C14 . . 124.3(2) ? C12 C13 H13 . . 117.9 ? C14 C13 H13 . . 117.9 ? C13 C14 C1 . . 112.63(17) ? C13 C14 H14A . . 109.1 ? C1 C14 H14A . . 109.1 ? C13 C14 H14B . . 109.1 ? C1 C14 H14B . . 109.1 ? H14A C14 H14B . . 107.8 ? C16 C15 C1 . . 111.91(18) ? C16 C15 C17 . . 106.55(18) ? C1 C15 C17 . . 111.04(18) ? C16 C15 C11 . . 112.98(17) ? C1 C15 C11 . . 105.87(17) ? C17 C15 C11 . . 108.51(18) ? C15 C16 H16A . . 109.5 ? C15 C16 H16B . . 109.5 ? H16A C16 H16B . . 109.5 ? C15 C16 H16C . . 109.5 ? H16A C16 H16C . . 109.5 ? H16B C16 H16C . . 109.5 ? C15 C17 H17C . . 109.5 ? C15 C17 H17A . . 109.5 ? H17C C17 H17A . . 109.5 ? C15 C17 H17B . . 109.5 ? H17C C17 H17B . . 109.5 ? H17A C17 H17B . . 109.5 ? C12 C18 H18B . . 109.5 ? C12 C18 H18C . . 109.5 ? H18B C18 H18C . . 109.5 ? C12 C18 H18A . . 109.5 ? H18B C18 H18A . . 109.5 ? H18C C18 H18A . . 109.5 ? C8 C19 H19A . . 109.5 ? C8 C19 H19B . . 109.5 ? H19A C19 H19B . . 109.5 ? C8 C19 H19C . . 109.5 ? H19A C19 H19C . . 109.5 ? H19B C19 H19C . . 109.5 ? C21 O20 C2 . . 110.57(17) ? O23 C21 O22 . . 124.3(2) ? O23 C21 O20 . . 124.0(2) ? O22 C21 O20 . . 111.64(18) ? C21 O22 C1 . . 111.30(16) ? C25 O24 C7 . . 118.46(17) ? O26 C25 O24 . . 123.99(19) ? O26 C25 C27 . . 124.93(19) ? O24 C25 C27 . . 111.07(19) ? C32 C27 C28 . . 119.1(2) ? C32 C27 C25 . . 122.10(19) ? C28 C27 C25 . . 118.8(2) ? C29 C28 C27 . . 120.1(2) ? C29 C28 H28 . . 120.0 ? C27 C28 H28 . . 120.0 ? C30 C29 C28 . . 120.3(2) ? C30 C29 H29 . . 119.8 ? C28 C29 H29 . . 119.8 ? C29 C30 C31 . . 120.0(2) ? C29 C30 H30 . . 120.0 ? C31 C30 H30 . . 120.0 ? C32 C31 C30 . . 120.0(2) ? C32 C31 H31 . . 120.0 ? C30 C31 H31 . . 120.0 ? C31 C32 C27 . . 120.5(2) ? C31 C32 H32 . . 119.7 ? C27 C32 H32 . . 119.7 ? C35 O34 C4 . . 115.90(17) ? O36 C35 O34 . . 114.22(17) ? O36 C35 H35A . . 108.7 ? O34 C35 H35A . . 108.7 ? O36 C35 H35B . . 108.7 ? O34 C35 H35B . . 108.7 ? H35A C35 H35B . . 107.6 ? C35 O36 C37 . . 113.22(18) ? O36 C37 H37B . . 109.5 ? O36 C37 H37C . . 109.5 ? H37B C37 H37C . . 109.5 ? O36 C37 H37A . . 109.5 ? H37B C37 H37A . . 109.5 ? H37C C37 H37A . . 109.5 ? loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion _geom_torsion_publ_flag O22 C1 C2 O20 . . . . 3.79(19) ? C14 C1 C2 O20 . . . . -111.28(19) ? C15 C1 C2 O20 . . . . 120.08(18) ? O22 C1 C2 C3 . . . . 129.13(18) ? C14 C1 C2 C3 . . . . 14.1(3) ? C15 C1 C2 C3 . . . . -114.6(2) ? O20 C2 C3 C4 . . . . 7.8(2) ? C1 C2 C3 C4 . . . . -113.8(2) ? O20 C2 C3 C8 . . . . -120.39(18) ? C1 C2 C3 C8 . . . . 118.0(2) ? C2 C3 C4 O34 . . . . 63.5(2) ? C8 C3 C4 O34 . . . . -170.62(16) ? C2 C3 C4 C5 . . . . -177.00(18) ? C8 C3 C4 C5 . . . . -51.1(2) ? O34 C4 C5 C6 . . . . 169.18(18) ? C3 C4 C5 C6 . . . . 51.9(3) ? C4 C5 C6 C7 . . . . -55.8(2) ? C5 C6 C7 O24 . . . . 179.09(17) ? C5 C6 C7 C8 . . . . 60.2(2) ? O24 C7 C8 C19 . . . . -55.8(2) ? C6 C7 C8 C19 . . . . 65.3(2) ? O24 C7 C8 C3 . . . . -178.79(16) ? C6 C7 C8 C3 . . . . -57.6(2) ? O24 C7 C8 C9 . . . . 63.7(2) ? C6 C7 C8 C9 . . . . -175.17(17) ? C4 C3 C8 C19 . . . . -69.6(2) ? C2 C3 C8 C19 . . . . 57.8(2) ? C4 C3 C8 C7 . . . . 52.1(2) ? C2 C3 C8 C7 . . . . 179.44(17) ? C4 C3 C8 C9 . . . . 166.90(18) ? C2 C3 C8 C9 . . . . -65.7(2) ? C19 C8 C9 C10 . . . . -63.2(2) ? C7 C8 C9 C10 . . . . 177.06(18) ? C3 C8 C9 C10 . . . . 61.6(2) ? C8 C9 C10 O33 . . . . 86.1(2) ? C8 C9 C10 C11 . . . . -98.0(2) ? O33 C10 C11 C12 . . . . 158.08(19) ? C9 C10 C11 C12 . . . . -17.9(3) ? O33 C10 C11 C15 . . . . -72.9(3) ? C9 C10 C11 C15 . . . . 111.1(2) ? C10 C11 C12 C13 . . . . 104.9(2) ? C15 C11 C12 C13 . . . . -25.8(3) ? C10 C11 C12 C18 . . . . -75.4(2) ? C15 C11 C12 C18 . . . . 153.96(19) ? C18 C12 C13 C14 . . . . -176.4(2) ? C11 C12 C13 C14 . . . . 3.3(3) ? C12 C13 C14 C1 . . . . -11.5(3) ? O22 C1 C14 C13 . . . . 161.48(17) ? C15 C1 C14 C13 . . . . 42.9(2) ? C2 C1 C14 C13 . . . . -85.5(2) ? O22 C1 C15 C16 . . . . 55.9(2) ? C14 C1 C15 C16 . . . . 172.61(17) ? C2 C1 C15 C16 . . . . -56.1(2) ? O22 C1 C15 C17 . . . . -63.0(2) ? C14 C1 C15 C17 . . . . 53.7(2) ? C2 C1 C15 C17 . . . . -175.02(17) ? O22 C1 C15 C11 . . . . 179.44(16) ? C14 C1 C15 C11 . . . . -63.9(2) ? C2 C1 C15 C11 . . . . 67.4(2) ? C12 C11 C15 C16 . . . . 176.93(18) ? C10 C11 C15 C16 . . . . 47.6(3) ? C12 C11 C15 C1 . . . . 54.1(2) ? C10 C11 C15 C1 . . . . -75.2(2) ? C12 C11 C15 C17 . . . . -65.1(2) ? C10 C11 C15 C17 . . . . 165.54(18) ? C3 C2 O20 C21 . . . . -131.96(18) ? C1 C2 O20 C21 . . . . -1.6(2) ? C2 O20 C21 O23 . . . . 178.3(2) ? C2 O20 C21 O22 . . . . -1.6(2) ? O23 C21 O22 C1 . . . . -175.5(2) ? O20 C21 O22 C1 . . . . 4.4(2) ? C14 C1 O22 C21 . . . . 117.38(19) ? C15 C1 O22 C21 . . . . -122.62(19) ? C2 C1 O22 C21 . . . . -5.0(2) ? C6 C7 O24 C25 . . . . 86.3(2) ? C8 C7 O24 C25 . . . . -150.29(18) ? C7 O24 C25 O26 . . . . -2.7(3) ? C7 O24 C25 C27 . . . . 175.64(17) ? O26 C25 C27 C32 . . . . -171.9(2) ? O24 C25 C27 C32 . . . . 9.8(3) ? O26 C25 C27 C28 . . . . 9.1(3) ? O24 C25 C27 C28 . . . . -169.24(19) ? C32 C27 C28 C29 . . . . -1.1(3) ? C25 C27 C28 C29 . . . . 177.9(2) ? C27 C28 C29 C30 . . . . 0.4(3) ? C28 C29 C30 C31 . . . . 0.7(4) ? C29 C30 C31 C32 . . . . -1.0(4) ? C30 C31 C32 C27 . . . . 0.2(4) ? C28 C27 C32 C31 . . . . 0.8(3) ? C25 C27 C32 C31 . . . . -178.2(2) ? C5 C4 O34 C35 . . . . 100.2(2) ? C3 C4 O34 C35 . . . . -138.79(18) ? C4 O34 C35 O36 . . . . -72.6(2) ? O34 C35 O36 C37 . . . . -68.7(2) ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_site_symmetry_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_publ_flag C14 H14A O34 . 0.99 2.65 3.479(3) 141.9 no C31 H31 O33 3_767 0.95 2.35 3.147(3) 141 yes C19 H19C O23 3_766 0.98 2.43 3.310(3) 149 yes C16 H16A O23 3_766 0.98 2.56 3.491(3) 158 yes _shelx_res_checksum 45243 _iucr_refine_instructions_details ; TITL mo_141219Oishi_2_0m in P2(1)/c CELL 0.71073 13.2416 13.1779 15.2428 90.000 109.387 90.000 ZERR 4.00 0.0008 0.0008 0.0008 0.000 0.002 0.000 LATT 1 SYMM -X, 0.5+Y, 0.5-Z SFAC C H O UNIT 116 144 32 L.S. 4 OMIT 1 1 0 OMIT 11 4 3 ACTA 50 SHEL 20 0.84 BOND $H FMAP 2 PLAN 5 HTAB C14 O34 EQIV $10 2-x, 1-y, 2-z EQIV $11 2-x, 1-y, 1-z EQIV $12 x, 3/2-y, -1/2+z HTAB C31 O33_$10 HTAB C16 O23_$11 HTAB C19 O23_$11 MPLA 5 O20 C2 C1 O22 C21 MPLA 4 C1 C2 O20 C21 O22 MPLA 4 C14 C13 C12 C11 C15 C1 RTAB dist H2 H16A RTAB dist C2 C16 RTAB dist O36 C25_$12 SIZE 0.90 0.14 0.22 TEMP -183.000 WGHT 0.037300 2.230700 FVAR 0.13067 MOLE 1 C1 1 0.818415 0.327121 0.492108 11.00000 0.01889 0.01747 = 0.01331 -0.00159 0.00917 0.00146 C2 1 0.832651 0.435043 0.536126 11.00000 0.01889 0.01484 = 0.01491 0.00256 0.00786 -0.00095 AFIX 13 H2 2 0.893916 0.431191 0.595893 11.00000 -1.20000 AFIX 0 C3 1 0.738318 0.485665 0.558348 11.00000 0.01494 0.01255 = 0.01519 -0.00157 0.00562 -0.00017 AFIX 13 H3 2 0.678683 0.435048 0.542158 11.00000 -1.20000 AFIX 0 C4 1 0.695300 0.580091 0.498299 11.00000 0.01660 0.01471 = 0.01298 -0.00118 0.00372 -0.00037 AFIX 13 H4 2 0.755099 0.628998 0.504819 11.00000 -1.20000 AFIX 0 C5 1 0.607346 0.631702 0.524208 11.00000 0.02162 0.01630 = 0.01836 0.00279 0.00711 0.00572 AFIX 23 H5A 2 0.542984 0.587860 0.505488 11.00000 -1.20000 H5B 2 0.588395 0.696243 0.489352 11.00000 -1.20000 AFIX 0 C6 1 0.639408 0.653843 0.628261 11.00000 0.02277 0.01590 = 0.02126 -0.00061 0.01089 0.00409 AFIX 23 H6A 2 0.698976 0.703383 0.646599 11.00000 -1.20000 H6B 2 0.577996 0.683427 0.642670 11.00000 -1.20000 AFIX 0 C7 1 0.673898 0.556144 0.681643 11.00000 0.01919 0.01596 = 0.01122 -0.00355 0.00609 -0.00349 AFIX 13 H7 2 0.612214 0.507770 0.664046 11.00000 -1.20000 AFIX 0 C8 1 0.770329 0.505005 0.664564 11.00000 0.01539 0.01564 = 0.01289 -0.00098 0.00576 -0.00156 C9 1 0.787271 0.402132 0.717912 11.00000 0.01989 0.01703 = 0.01497 -0.00026 0.00697 0.00010 AFIX 23 H9A 2 0.802215 0.417619 0.784584 11.00000 -1.20000 H9B 2 0.718528 0.364796 0.696290 11.00000 -1.20000 AFIX 0 C10 1 0.874223 0.330347 0.711000 11.00000 0.02087 0.01821 = 0.01371 0.00521 0.00555 -0.00071 C11 1 0.847776 0.239893 0.642330 11.00000 0.01864 0.01343 = 0.01786 0.00238 0.00487 0.00102 AFIX 13 H11 2 0.885253 0.179918 0.679068 11.00000 -1.20000 AFIX 0 C12 1 0.729832 0.213570 0.609171 11.00000 0.01972 0.01284 = 0.02012 -0.00341 0.00893 -0.00104 C13 1 0.666331 0.237892 0.524435 11.00000 0.01798 0.01325 = 0.02263 -0.00403 0.00696 -0.00117 AFIX 43 H13 2 0.592250 0.222755 0.508354 11.00000 -1.20000 AFIX 0 C14 1 0.703794 0.287746 0.452288 11.00000 0.01915 0.01507 = 0.01543 -0.00134 0.00209 0.00094 AFIX 23 H14A 2 0.655510 0.345057 0.424296 11.00000 -1.20000 H14B 2 0.699391 0.238261 0.402284 11.00000 -1.20000 AFIX 0 C15 1 0.891660 0.249897 0.559356 11.00000 0.01902 0.01446 = 0.01968 -0.00028 0.00654 0.00229 C16 1 1.009753 0.282150 0.590147 11.00000 0.02036 0.01789 = 0.02567 0.00259 0.00943 0.00508 AFIX 137 H16A 2 1.034637 0.281618 0.536350 11.00000 -1.50000 H16B 2 1.052835 0.234710 0.637284 11.00000 -1.50000 H16C 2 1.017140 0.350703 0.616452 11.00000 -1.50000 AFIX 0 C17 1 0.885091 0.145297 0.512885 11.00000 0.02599 0.01672 = 0.02517 -0.00135 0.01060 0.00244 AFIX 137 H17A 2 0.812071 0.118770 0.497037 11.00000 -1.50000 H17B 2 0.935142 0.098514 0.555875 11.00000 -1.50000 H17C 2 0.903878 0.151999 0.456150 11.00000 -1.50000 AFIX 0 C18 1 0.692080 0.158573 0.678476 11.00000 0.02426 0.02094 = 0.02286 -0.00026 0.00962 -0.00107 AFIX 137 H18A 2 0.614402 0.148832 0.652778 11.00000 -1.50000 H18B 2 0.709610 0.198542 0.735811 11.00000 -1.50000 H18C 2 0.727517 0.092349 0.692203 11.00000 -1.50000 AFIX 0 C19 1 0.870578 0.571561 0.701921 11.00000 0.02047 0.01798 = 0.01806 -0.00282 0.00738 -0.00013 AFIX 137 H19A 2 0.861666 0.633008 0.663879 11.00000 -1.50000 H19B 2 0.933194 0.533708 0.699246 11.00000 -1.50000 H19C 2 0.880910 0.590481 0.766498 11.00000 -1.50000 AFIX 0 O20 3 0.868052 0.496304 0.472598 11.00000 0.01994 0.01524 = 0.01775 -0.00135 0.01088 -0.00154 O22 3 0.855231 0.341365 0.412685 11.00000 0.02579 0.01646 = 0.01769 -0.00144 0.01221 -0.00015 O23 3 0.903566 0.471311 0.340358 11.00000 0.02538 0.02664 = 0.02005 0.00038 0.01394 -0.00389 O24 3 0.706512 0.575498 0.781100 11.00000 0.01935 0.01939 = 0.01390 -0.00318 0.00791 -0.00101 O26 3 0.536858 0.564178 0.781056 11.00000 0.01753 0.02253 = 0.02110 -0.00295 0.00662 -0.00190 O33 3 0.965599 0.340296 0.763624 11.00000 0.02047 0.02644 = 0.02003 -0.00047 0.00164 0.00176 O34 3 0.653803 0.544466 0.404087 11.00000 0.02484 0.01789 = 0.01244 0.00183 0.00685 0.00172 O36 3 0.617655 0.696142 0.317699 11.00000 0.02026 0.01619 = 0.02206 0.00468 0.00521 -0.00044 C37 1 0.506541 0.681218 0.270535 11.00000 0.02004 0.02429 = 0.02755 0.00556 0.00656 0.00140 AFIX 137 H37A 2 0.496677 0.639310 0.215197 11.00000 -1.50000 H37B 2 0.471680 0.747084 0.251827 11.00000 -1.50000 H37C 2 0.474614 0.646965 0.312044 11.00000 -1.50000 AFIX 0 C35 1 0.675904 0.605415 0.337208 11.00000 0.02408 0.02548 = 0.01623 0.00510 0.00866 0.00665 AFIX 23 H35A 2 0.753252 0.621805 0.359209 11.00000 -1.20000 H35B 2 0.660289 0.566043 0.278890 11.00000 -1.20000 AFIX 0 C32 1 0.786457 0.613924 0.966035 11.00000 0.02433 0.02136 = 0.02123 -0.00252 0.01065 -0.00074 AFIX 43 H32 2 0.830373 0.625253 0.928765 11.00000 -1.20000 AFIX 0 C31 1 0.829566 0.622706 1.061450 11.00000 0.02631 0.02300 = 0.02200 -0.00348 0.00291 -0.00331 AFIX 43 H31 2 0.902825 0.640274 1.089630 11.00000 -1.20000 AFIX 0 C30 1 0.766061 0.605919 1.116086 11.00000 0.03906 0.01962 = 0.01500 0.00121 0.00523 0.00491 AFIX 43 H30 2 0.795974 0.610923 1.181850 11.00000 -1.20000 AFIX 0 C29 1 0.659735 0.582011 1.075194 11.00000 0.03331 0.02408 = 0.01718 0.00268 0.01285 0.00410 AFIX 43 H29 2 0.616092 0.571231 1.112792 11.00000 -1.20000 AFIX 0 C28 1 0.615868 0.573550 0.979410 11.00000 0.02559 0.01568 = 0.02352 0.00095 0.00981 0.00219 AFIX 43 H28 2 0.542198 0.557385 0.951485 11.00000 -1.20000 AFIX 0 C27 1 0.679492 0.588680 0.924082 11.00000 0.01989 0.01079 = 0.01456 0.00027 0.00609 0.00217 C25 1 0.631104 0.575668 0.822161 11.00000 0.01708 0.00793 = 0.02218 0.00040 0.01086 0.00134 C21 1 0.877904 0.439023 0.403022 11.00000 0.01266 0.01841 = 0.01756 -0.00075 0.00222 0.00239 HKLF 4 REM mo_141219Oishi_2_0m in P2(1)/c REM R1 = 0.0439 for 3050 Fo > 4sig(Fo) and 0.0832 for all 4395 data REM 339 parameters refined using 0 restraints END WGHT 0.0364 1.5003 REM Highest difference peak 0.287, deepest hole -0.245, 1-sigma level 0.053 Q1 1 0.6934 0.2630 0.5930 11.00000 0.05 0.29 Q2 1 0.7381 0.5677 0.9504 11.00000 0.05 0.25 Q3 1 0.6591 0.3471 0.3922 11.00000 0.05 0.25 Q4 1 0.7199 0.5350 0.5302 11.00000 0.05 0.23 Q5 1 0.6463 0.5432 0.9337 11.00000 0.05 0.22 ;