#The evolutionarily stable distribution of fitness effects #File S1 #Daniel P. Rice, Benjamin H. Good, and Michael M. Desai #12/20/14 # #This file contains a table of parameters for all simulations included in the #main text and supplemental figures. # #In order to find the steady state stilde for each set of parameters, we #varied the initial stilde and recorded the fitness change during the #simulation. After finding two values of stilde bracketing the steady state #(stilde_min and stilde_max), we ran 100 replicate simulations starting from #each. We confirmed convergence to the steady state DFE by plotting the #distribution of fixed mutations (Fig. S1). # #Parameters: #R per-genome per-generation recombination rate #beta underlying DFE shape parameter #N population size #U per-genome per-generation mutation rate #s0 underlying DFE scale parameter #L genome length #Tmax simulation runtime in generations #stilde_min initial DFE parameter below steady state #stilde_max initial DFE parameter above steady state # R,beta,N,U,s0,L,Tmax,stilde_min,stilde_max 0.0,1,10000,0.0001,0.001,100000,1000000000,1.190e-04,1.205e-04 0.0,1,10000,0.0001,0.01,100000,1000000000,1.026e-04,1.036e-04 0.0,1,10000,0.0001,0.1,100000,1000000000,9.950e-05,1.005e-04 0.0,1,100000,0.00001,0.1,100000,1000000000,9.950e-06,1.005e-05 0.0,1,10000,0.001,0.001,100000,100000000,2.564e-04,2.632e-04 0.0,1,10000,0.001,0.01,100000,100000000,1.481e-04,1.504e-04 0.0,1,10000,0.001,0.1,100000,1000000000,1.064e-04,1.075e-04 0.0,1,100000,0.0001,0.1,100000,1000000000,1.031e-05,1.042e-05 0.0,1,10000,0.01,0.001,100000,10000000,8.000e-04,8.696e-04 0.0,1,10000,0.01,0.01,100000,10000000,7.143e-04,7.692e-04 0.0,1,10000,0.01,0.1,100000,100000000,1.852e-04,1.852e-04 0.0,1,100000,0.001,0.1,100000,100000000,1.087e-05,1.099e-05 0.0,1,100000,0.01,0.0001,100000,5000000,2.165e-04,2.169e-04 0.0,1,100000,0.01,0.001,100000,10000000,4.762e-04,5.000e-04 0.0,1,100000,0.01,0.01,100000,10000000,2.273e-04,2.326e-04 0.0,1,100000,0.01,0.1,100000,10000000,2.273e-05,2.381e-05 0.0,1,100000,0.1,0.0001,100000,200000,4.843e-04,4.854e-04 0.0,1,100000,0.1,0.001,100000,100000,1.639e-03,1.653e-03 0.0,1,100000,0.1,0.01,100000,1000000,3.333e-03,3.571e-03 0.0,1,100000,0.1,0.1,100000,1000000,8.621e-04,8.772e-04 0.0,1,10000,0.002,0.01,100000,100000000,2.041e-04,2.083e-04 0.0,1,10000,0.004,0.01,100000,100000000,3.226e-04,3.333e-04 0.0,1,10000,0.006,0.01,100000,100000000,4.545e-04,4.762e-04 0.0,1,10000,0.008,0.01,100000,100000000,5.882e-04,6.250e-04 0.0,0.75,10000,0.0001,0.01,100000,1000000000,1.031e-04,1.042e-04 0.0,0.75,10000,0.001,0.01,100000,100000000,1.370e-04,1.389e-04 0.0,0.75,10000,0.01,0.01,100000,10000000,5.882e-04,6.250e-04 0.0,0.75,100000,0.01,0.001,100000,5000000,4.762e-04,5.000e-04 0.0,0.75,100000,0.1,0.001,100000,500000,2.000e-03,2.041e-03 0.0,2,10000,0.0001,0.01,100000,1000000000,1.042e-04,1.053e-04 0.0,2,10000,0.001,0.01,100000,100000000,1.587e-04,1.613e-04 0.0,2,10000,0.01,0.01,100000,10000000,9.091e-04,1.000e-03 0.0,2,100000,0.01,0.001,100000,5000000,4.630e-04,4.651e-04 0.0,2,100000,0.1,0.001,100000,500000,1.235e-03,1.242e-03 0.0,Infinty,10000,0.0001,0.01,100000,1000000000,1.042e-04,1.053e-04 0.0,Infinty,10000,0.001,0.01,100000,100000000,1.563e-04,1.587e-04 0.0,Infinty,10000,0.01,0.01,100000,10000000,9.091e-04,1.000e-03 0.0,Infinty,100000,0.01,0.001,100000,5000000,4.673e-04,4.684e-04 0.0,Infinty,100000,0.1,0.001,100000,500000,1.136e-03,1.143e-03 0.0,1,1000,0.1,0.01,10000,100000000,4.25e-3,4.30e-3 0.01,1,1000,0.1,0.01,10000,50000000,3.25e-3,3.30e-3 0.1,1,1000,0.1,0.01,10000,10000000,1.45e-3,1.50e-3 1.0,1,1000,0.1,0.01,10000,1000000,6.00e-4,7.00e-4