53 pathway holes were filled.
|
Reaction
|
EC#
|
Hole-filler
|
P(has-function)
|
Pathway(s) needing this reaction
|
|
Phosphogluconate dehydrogenase (decarboxylating)
|
1.1.1.44
|
CC1574
|
0.730
|
oxidative branch of the pentose phosphate pathway ,
superpathway for gluconate degradation
|
|
Formate dehydrogenase
|
1.2.1.2
|
CC0617
|
0.950
|
respiration (anaerobic)
|
|
Glucose 1-dehydrogenase
|
1.1.1.47
|
CC0821
|
0.982
|
non-phosphorylated glucose degradation
|
|
Methylenetetrahydrofolate dehydrogenase (NADP+)
|
1.5.1.5
|
CC1217
|
1.000
|
folic acid biosynthesis ,
formylTHF biosynthesis
|
|
Methenyltetrahydrofolate cyclohydrolase
|
3.5.4.9
|
CC1217
|
1.000
|
folic acid biosynthesis ,
formylTHF biosynthesis
|
|
RXN0-884
|
[none]
|
CC3361
|
0.982
|
isopentenyl diphosphate biosynthesis -- mevalonate-independent
|
|
RXN0-882
|
[none]
|
CC0851
|
0.996
|
isopentenyl diphosphate biosynthesis -- mevalonate-independent
|
|
R142-RXN
|
2.7.-.-
|
CC1336
|
0.778
|
isopentenyl diphosphate biosynthesis -- mevalonate-independent
|
|
2-dehydropantoate 2-reductase
|
1.1.1.169
|
CC0261
|
0.863
|
pantothenate and coenzyme A biosynthesis
|
|
Dephospho-CoA kinase
|
2.7.1.24
|
CC0004
|
1.000
|
pantothenate and coenzyme A biosynthesis
|
|
Nicotinate-nucleotide adenylyltransferase
|
2.7.7.18
|
CC3431
|
0.924
|
pyridine nucleotide biosynthesis
|
|
NAD(+) synthase (glutamine-hydrolysing)
|
6.3.5.1
|
CC3619
|
0.999
|
pyridine nucleotide biosynthesis
|
|
L-ASPARTATE-OXID-RXN
|
1.4.3.-
|
CC2913
|
0.999
|
pyridine nucleotide biosynthesis
|
|
Alkane-1 monooxygenase
|
1.14.15.3
|
CC2997
|
0.981
|
octane oxidation
|
|
RXN0-268
|
2.8.3.-
|
CC3724
|
0.987
|
conversion of succinate to propionate
|
|
Dodecenoyl-CoA delta-isomerase
|
5.3.3.8
|
CC0076
|
0.942
|
fatty acid oxidation pathway
|
|
3-hydroxybutyryl-CoA epimerase
|
5.1.2.3
|
CC0076
|
0.906
|
fatty acid oxidation pathway
|
|
Acetyl-CoA C-acyltransferase
|
2.3.1.16
|
CC0077
|
0.974
|
fatty acid oxidation pathway
|
|
Hydroxypyruvate reductase
|
1.1.1.81
|
CC3722
|
0.961
|
serine-isocitrate lyase pathway
|
|
Valine--pyruvate aminotransferase
|
2.6.1.66
|
CC2162
|
0.999
|
alanine biosynthesis I
|
|
RXN0-1132
|
1.8.1.4
|
CC1731
|
1.000
|
pyruvate dehydrogenase
|
|
RXN0-1133
|
2.3.1.12
|
CC1729
|
0.954
|
pyruvate dehydrogenase
|
|
RXN0-1134
|
1.2.4.1
|
CC1727
|
1.000
|
pyruvate dehydrogenase
|
|
L-lactate dehydrogenase
|
1.1.1.27
|
CC3655
|
1.000
|
fructose degradation (anaerobic)
|
|
Maleylacetoacetate isomerase
|
5.2.1.2
|
CC3568
|
1.000
|
phenylalanine degradation I
|
|
Enoyl-CoA hydratase
|
4.2.1.17
|
CC1352
|
0.916
|
valine degradation I ,
valine degradation II
|
|
Glycerol-3-phosphate dehydrogenase (NAD(P)+)
|
1.1.1.94
|
CC0070
|
1.000
|
phospholipid biosynthesis ,
glycerol metabolism
|
|
PHOSGLUCOSAMINEMUT-RXN
|
[none]
|
CC0117
|
1.000
|
N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation ,
UDP-N-acetylglucosamine biosynthesis
|
|
CDPREDUCT-RXN
|
[none]
|
CC0260
|
0.998
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
CDPREDUCT-RXN
|
[none]
|
CC3492
|
0.993
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
UDPREDUCT-RXN
|
[none]
|
CC0260
|
0.998
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
UDPREDUCT-RXN
|
[none]
|
CC3492
|
0.993
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
DTDPKIN-RXN
|
[none]
|
CC1699
|
1.000
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
DUDPKIN-RXN
|
[none]
|
CC1699
|
1.000
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
DCDPKIN-RXN
|
2.7.4.6
|
CC1699
|
1.000
|
de novo biosynthesis of pyrimidine deoxyribonucleotides
|
|
RXN0-901
|
1.1.1.204
|
CC2618
|
0.994
|
salvage pathways of adenine, hypoxanthine, and their nucleosides
|
|
ADDALT-RXN
|
[none]
|
CC3180
|
0.990
|
salvage pathways of adenine, hypoxanthine, and their nucleosides
|
|
DADPKIN-RXN
|
2.7.4.6
|
CC1699
|
1.000
|
de novo biosynthesis of purine nucleotides I
|
|
DGDPKIN-RXN
|
2.7.4.6
|
CC1699
|
1.000
|
de novo biosynthesis of purine nucleotides I
|
|
ADPREDUCT-RXN
|
[none]
|
CC0260
|
1.000
|
de novo biosynthesis of purine nucleotides I
|
|
GDPKIN-RXN
|
[none]
|
CC1699
|
1.000
|
de novo biosynthesis of purine nucleotides I
|
|
IMP cyclohydrolase
|
3.5.4.10
|
CC0086
|
1.000
|
de novo biosynthesis of purine nucleotides I ,
de novo biosynthesis of purine nucleotides II
|
|
CDPKIN-RXN
|
[none]
|
CC1699
|
1.000
|
de novo biosynthesis of pyrimidine ribonucleotides ,
salvage pathways of pyrimidine ribonucleotides
|
|
UDPKIN-RXN
|
[none]
|
CC1699
|
1.000
|
de novo biosynthesis of pyrimidine ribonucleotides
|
|
Dimethylallyltransferase
|
2.5.1.1
|
CC2069
|
0.999
|
mevalonate pathway
|
|
Dihydrofolate synthase
|
6.3.2.12
|
CC3541
|
0.969
|
folic acid biosynthesis ,
formylTHF biosynthesis
|
|
Hydroxymethylpyrimidine kinase
|
2.7.1.49
|
CC3223
|
0.947
|
thiamine biosynthesis
|
|
FORMYLTHFGLUSYNTH-RXN
|
[none]
|
CC3541
|
0.947
|
formylTHF biosynthesis
|
|
Phosphomannomutase
|
5.4.2.8
|
CC0117
|
0.960
|
GDP-D-rhamnose biosynthesis ,
GDP-mannose metabolism ,
colanic acid building blocks biosynthesis
|
|
KDOTRANS2-RXN
|
2.-.-.-
|
CC0302
|
0.999
|
KDO biosynthesis -- including transfer to lipid IVA
|
|
PHOSNACMURPENTATRANS-RXN
|
[none]
|
CC2557
|
0.998
|
peptidoglycan biosynthesis
|
|
Tyrosine aminotransferase
|
2.6.1.5
|
CC1534
|
0.934
|
phenylalanine biosynthesis
|
|
Aromatic amino acid transferase
|
2.6.1.57
|
CC1534
|
0.978
|
phenylalanine biosynthesis I
|
|
Aromatic amino acid transferase
|
2.6.1.57
|
CC1534
|
0.978
|
tyrosine biosynthesis I
|
|
Histidinol-phosphatase
|
3.1.3.15
|
CC3734
|
0.981
|
histidine biosynthesis I
|