Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10

Data Supplement

Files in this Data Supplement:

• Supplemental Figures -

  Supplemental Figure 1 - Hypothesized structure of OTS167-G (A), structure of OTS167 (B), and fragment molecules (C) and (D)

  Supplemental Figure 2 - Multi-channel averaged Q1 mass spectrometry scan for OTS167

  Supplemental Figure 3 - Multi-channel averaged Q1 mass spectrometry scan for collected glucuronide peak formed during incubation with HLM

  Supplemental Figure 4 - Multi-channel averaged Q1 mass spectrometry scan for collected glucuronide peak formed during incubation with UGT1A1

  Supplemental Figure 5 - Multi-channel averaged Q1 mass spectrometry scan for collected glucuronide peak formed during incubation with UGT1A8