The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity

Supplemental material

• Supplemental file 1 -

  Fig. S1 (Simulated annealing omit difference electron density maps for glycan complex structures of Mad-1 and WT3 VP1.)

  Fig. S2 (Electron density integration within a 1.0-Å mask around marker residues of Mad-1 and WT3 VP1.)

  Table S1 (Structures of native JCPyV WT3 VP1 and of JCPyV WT3 VP1 in complex with LSTc, GM1, GM2, GD1a, and GD1a glycans.)

  Table S2 (JCPyV Mad-1 VP1 pentamers in complex with LSTc, GM1, GM2, GD1a, and GD1b glycans.)

  Table S3 (Data collection statistics of data sets used for concentration-dependent density integration of LSTc.)

  Table S4 (Data collection statistics of data sets used for concentration-dependent density integration of the GM1 glycan.)

  Table S5 (Data collection statistics of additional data sets used for concentration-dependent density integration of GM2.)

  Table S6 (Data collection statistics of additional data sets used for concentration-dependent density integration of GD1a.)

  Table S7 (Data collection statistics of additional data sets used for concentration-dependent density integration of GD1b.)

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